RAB3C Gene
protein-coding GIFtS: 50
GCID: GC05P057914
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RAB3C, member RAS oncogene family
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Aliases
for RAB3C gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| RAB3C, Member RAS Oncogene Family1 2 | | Ras-Related Protein Rab-3C2 |
Export aliases for RAB3C gene to outside databasesPrevious GC identifers: GC05P057849 GC05P057894 GC05P054835 |
Summaries
for RAB3C gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RAB3C:
RAB proteins, such as RAB3C, are small GTPases implicated in the regulation of vesicular trafficking between membranecompartments (Cheng et al., 2002 (PubMed 12296628)).(supplied by OMIM, Jun 2009)
UniProtKB/Swiss-Prot: RAB3C_HUMAN, Q96E17Function: Protein transport. Probably involved in vesicular traffic (By similarity)
Gene Wiki entry for RAB3C
|
Genomic Views
for RAB3C gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_006713.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RAB3C gene promoter:
GR AML1a FOXF2 GR-beta MIF-1 E47 FOXC1 c-Myb GR-alpha Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for RAB3C
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB3C |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q13 Ensembl cytogenetic band: 5q11.2 HGNC cytogenetic band: 5q13RAB3C Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P057914: view genomic region
(about GC identifiers)
Start:
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57,878,048 bp from pter |
End:
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58,155,213 bp from pter |
Size:
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277,166 bases |
Orientation:
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plus strand |
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Proteins
for RAB3C gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RAB3C_HUMAN, Q96E17 (See
protein sequence)Recommended Name: Ras-related protein Rab-3C Size: 227 amino acids; 25952 Da
Subunit: Interacts with RIMS1, RIMS2, RPH3A and RPH3AL (By similarity)
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)Explore the universe of human proteins at neXtProt for RAB3C: NX_Q96E17
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96E17
RAB3C Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_612462.1
ENSEMBL proteins: ENSP00000282878
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
RAB3C for ontologies About GeneDecksing
RAB3C Antibody Products:
Assay Products for RAB3C: |
Protein
Domains /
Families
for RAB3C gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RAB3C for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96E17ProtoNet protein and cluster: Q96E17 1 Blocks protein family: IPB001806 Transforming protein P21 RAS signature
UniProtKB/Swiss-Prot: RAB3C_HUMAN, Q96E17Similarity: Belongs to the small GTPase superfamily. Rab family |
Function
for RAB3C gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RAB3C_HUMAN, Q96E17Function: Protein transport. Probably involved in vesicular traffic (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAB3C (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAB3C (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for RAB3C | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB3C |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB3C |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
RAB3C for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Rab3ctm1Sud for RAB3C
7 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Rab3c):
RAB3C for phenotypes About GeneDecksing
|
Pathways & Interactions
for RAB3C gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Sertoli-Sertoli Cell Junction Dynamics | |
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RAB3C
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAB3C
STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)
5/12 Interacting proteins for RAB3C (Q96E173 ENSP000002828784) via UniProtKB, MINT, STRING, and/or I2D (see all 12)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007264 | small GTPase mediated signal transduction |
IEA | -- | | GO:0015031 | protein transport |
IEA | -- | | GO:0017157 | regulation of exocytosis |
IEA | -- |
RAB3C for ontologies About GeneDecksing
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Drugs & Compounds
for RAB3C gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RAB3C
Search CenterWatch for drugs/clinical trials and news about RAB3C
|
Transcripts
for RAB3C gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RAB3C gene: NM_138453.2 Unigene Cluster for RAB3C: RAB3C, member RAS oncogene family Hs.482173 [show with all ESTs]Unigene Representative Sequence: BC0130334 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000513316 ENST00000282878(uc003jrp.3) ENST00000507977 ENST00000381158
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAB3C (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAB3C (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RAB3C (NM_138453) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RAB3C | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB3C |
Additional cDNA sequence: AY026936.1 BC013033.2 2 DOTS entries: DT.205486 DT.100773169 24/28 AceView cDNA sequences (see all 28): BP360270 BM683101 NM_138453 BG181521 BX112487 BC013033 AA121806 BP362717 AI364134 AY026936 CK904541 BE263328 AA868463 CK904542 AI278619 BF438170 BI670306 BM069462 BX394661 BP361193 AL706809 BM054844 BG199104 BM054660
GeneLoc Exon Structure
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Expression
for RAB3C gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RAB3C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See RAB3C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RAB3C
SOURCE GeneReport for Unigene cluster: Hs.482173
UniProtKB/Swiss-Prot: RAB3C_HUMAN, Q96E17Tissue specificity: Expressed in brain, placenta and lung
SABiosciences Custom PCR Arrays for RAB3C
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAB3C
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RAB3C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAB3C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAB3C | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB3C |
Orthologs
for RAB3C gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RAB3C gene from 7/23 species (see all 23) About this table
ENSEMBL Gene Tree for RAB3C (if available)
TreeFam Gene Tree for RAB3C (if available) |
Paralogs
for RAB3C gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RAB3C gene
- RAB232 RAB27A2 RAB3A2 RAB3B2 RAB27B2 RAB3D2
18/85 SIMAP similar genes for RAB3C using alignment to 2 protein entries: RAB3C_HUMAN (see all proteins)
(see all similar genes):RAB3A RAB3B RAB3D RAB8B RAB13 RAB8A
RAB10 RAB15 RAB26 RAB39B RAB11A RAB27A
RAB37 RAB23 RAB41 RAB30 RAB11B DKFZp686J07132
RAB3C for paralogs About GeneDecksing
|
Genomic Variants
for RAB3C gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RAB3C (57878048 - 58128048 bp, first 250kb of RAB3C)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 13 variations for RAB3C
8 CNVs: 69072 37966 6408 64212 36423 99150 93063 69071
5 Indels: 40758 10779 46904 27969 10778 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAB3C |
|
Disorders
/ Diseases
for RAB3C gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RAB3C for disorders About GeneDecksing
OMIM gene information: 612829
OMIM disorders: --
4  diseases for RAB3C: About MalaCardsinsulin resistance pharyngitis neuronitis alcoholism
Human Genome Epidemiology (HuGE) Navigator: RAB3C (2 documents)
Export disorders for RAB3C gene to outside databases
|
Publications
for RAB3C gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RAB3C gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with RAB3C) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning, mapping, and characterization of the human Rab3C gene. (PubMed id 12296628)1, 2, 3, 9 Cheng H....Ma Y. (2002)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1 Trynka G....Wijmenga C. (2009)
- The GTPase Rab3b/3c-positive recycling vesicles are i nvolved in cross-presentation in dendritic cells. (PubMed id 19717423)1 Zou L....Wu Y. (2009)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells. (PubMed id 15159548)1 Matsumoto M....Seino S. (2004)
- Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2. (PubMed id 12578829)1 Fukuda M. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Localization versus function of Rab3 proteins. Evidence for a common regulatory role in controlling fusion. (PubMed id 12167638)1 Schluter O.M....Sudhof T.C. (2002)
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External Searches for RAB3C gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RAB3C gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RAB3C gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RAB3C gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for RAB3C gene:
Search GeneIP for patents involving RAB3C
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RAB3C gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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variant library, vector shuttling | | | OriGene Custom Antibody Services for RAB3C | | OriGene Custom Protein Services for RAB3C | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RAB3C | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAB3C | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB3C | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAB3C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAB3C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAB3C |
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| | | | Search Tocris compounds for RAB3C |
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 | | | RAB3C Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB3C |
|  |  |  | | | | ThermoFisher Antibody for RAB3C |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB3C |
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