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RAB3C Gene

protein-coding   GIFtS: 53

GC05P057914
RAB3C, member RAS oncogene family
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Descriptions
RAB3C, member RAS oncogene family 2
External Ids
HGNC: 302691
Entrez Gene: 1158272
UniProtKB: Q96E173
Ensembl: ENSG000001529327
Search outside databases for aliases for RAB3C gene

Previous GC identifers: GC05P057849 GC05P057894

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: RAB3C_HUMAN, Q96E17
Function: Protein transport. Probably involved in vesicular traffic (By similarity)

Gene Wiki entry for RAB3C

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the RAB3C gene  

Entrez Gene cytogenetic band: 5q13   Ensembl cytogenetic band:  5q11.2   HGNC cytogenetic band: 5q13

RAB3C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P057914:     (about GC identifiers)

Start:
57,914,696 bp from pter
End:
58,183,163 bp from pter
Size:
268,468 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000005.8  NT_006713.14  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: RAB3C_HUMAN, Q96E17 (See protein sequence)
Recommended Name: Ras-related protein Rab-3C  
Size: 227 amino acids; 25952 Da
Subunit: Binds RIMS1 (By similarity)
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)

REFSEQ proteins: NP_612462.1  

ENSEMBL proteins: 
ENSP00000282878 ENSP00000370550 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Sigma-Aldrich AQUA Peptides for RAB3C  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (Rab3A + Rab3B + Rab3C + Rab3D, Rab3C)
Human Recombinant Proteins from Abnova (RAB3C)
              OriGene Purified Recombinant Human Protein: RAB3C 

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005737 cytoplasm IDA18029348
GO:0005886 plasma membrane IEA--
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Antibodies for RAB3C: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for RAB3C
Browse R&D Systems for Antibodies
Antibodies from Abcam (Rab3A + Rab3B + Rab3C + Rab3D, Rab3C), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (RAB3C)
Novus Biologicals Antibody for RAB3C

Assays for RAB3C: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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5 InterPro domains/families:
 IPR015596 Rab3
 IPR001806 Ras_GTPase
 IPR005225 Small_GTP_bd
 IPR003579 GTPase_Rab
 IPR013753 Ras


   GeneDecks  RAB3C for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q96E17

ProtoNet protein and cluster: Q96E17

1 Blocks protein family: IPB001806 Transforming protein P21 RAS signature

UniProtKB/Swiss-Prot: RAB3C_HUMAN, Q96E17
Similarity: Belongs to the small GTPase superfamily. Rab family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (RAB3C)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_138453

              Applied Biosystems Silencer® siRNAs for RAB3C

              Sigma-Aldrich siRNA for RAB3C  
                     Sigma-Aldrich shRNA for RAB3C  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for RAB3C
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_138453
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_138453
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_138453 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_138453

UniProtKB/Swiss-Prot: RAB3C_HUMAN, Q96E17
Function: Protein transport. Probably involved in vesicular traffic (By similarity)

7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rab3c):

behavior/neurologicalgrowth/sizehomeostasis/metabolismlethality-prenatal/perinatalnervous system
normalrespiratory system

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0000166 nucleotide binding IEA--
GO:0005525 GTP binding IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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 Gene Network CentralTM Interacting Genes and Proteins Network for  RAB3C 


5 Interacting proteins for RAB3C (ENSP000003705503) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
RPH3ALENSP000003192103STRING (score=.928)
RIMS2ENSP000003321843STRING (score=.883)
RIMS1ENSP000002648393STRING (score=.779)
RAB3GAP1ENSP000002641583STRING (score=.749)
--ENSP000003538363STRING (score=.978)
About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA--
GO:0015031 protein transport IEA--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for RAB3C
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for RAB3C

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (RAB3C)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_138453

              Sigma-Aldrich siRNA for RAB3C  
                     Sigma-Aldrich shRNA for RAB3C  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_138453  

REFSEQ mRNAs for RAB3C gene: 

NM_138453.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_138453  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_138453
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_138453
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_138453 

Additional cDNA sequence: 

AY026936.1 BC013033.2 

2 DOTS entries:

DT.205486  DT.100773169 

24/28 AceView cDNA sequences (see all 28 ):

BX112487 BP360270 BM683101 BG181521 BC013033 NM_138453 AA868463 CK904542 
BX394661 BP362717 BM069462 AY026936 BI670306 AI278619 CK904541 BE263328 
BF438170 AA121806 AI364134 BP361193 BM054660 AL706809 BM054844 BG199104 

highest scoring ESTs for RAB3C:

AI278619 AA121806 AI364134 AL706809 AY026936 BC013033 BE263328 BF438170 BG055348 BG181521 

Unigene Cluster for RAB3C:

RAB3C, member RAS oncogene family
Hs.482173  [show with all ESTs]
Unigene Representative Sequence: BC013033


GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:
ENST00000282878  ENST00000381158  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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RAB3C expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for RAB3C

1 / 2 / 3

3 probe-sets matching RAB3C gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

46049_at2, 3 U95-B 1 1.00 1.00 1.00 1.00 AI278619 1.00 1.00 1.00 1

242328_at2, 3 U133-B 1 0.27 1.00 -- -- BG055348 0.80 1.00 0.91 1

242328_at2 U133Plus2 1 0.27 1.00 -- -- -- -- -- -- --
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Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.482173
(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for RAB3C gene from 5/9 species (see all 9 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
RAB3C1   -- RAB3C, member RAS oncogene family 93.76(n)
98.17(a)
608817  XM_845952.1  XP_851045.1 
chimpanzee
(Pan troglodytes)
RAB3C1   -- RAB3C, member RAS oncogene family 99.7(n)
100(a)
471537  XM_526915.2  XP_526915.2 
cow
(Bos taurus)
RAB3C1   -- RAB3C, member RAS oncogene family 93.39(n)
99.56(a)
617600  NM_001046606.1  NP_001040071.1 
rat
(Rattus norvegicus)
Rab3c1   -- RAB3C, member RAS oncogene family 88.69(n)
97.36(a)
171058  NM_133536.1  NP_598220.1 
mouse
(Mus musculus)
Rab3c1, 5 135
RAB3C, member RAS oncogene family1, 5 89.43(n)1
97.36(a)1
672951  NM_023852.41  NP_076341.11 
 AB2325895  AF3075155  (see all 18)
About this table        Species with no ortholog for RAB3C

ENSEMBL Gene Tree for RAB3C
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for RAB3C gene
RAB3A2  RAB3B2  RAB122  RAB3D2  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/1606 NCBI SNPs in RAB3C are shown (see all 1606 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 586)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 5 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs18766911,2
A,C,F,H,O57914620(-) CTGCCG/TAGGAG 1 -- ng5113Minor allele frequency- T:0.10EU EA WA NA 1162
rs2956691,2
A,C,F,H,O58183213(+) ATTTGT/CTCTCA 1 -- ng31 ese316Minor allele frequency- C:0.31EA NA EU WA 2886
rs2956701,2
A,C,F,H58183510(+) ATTAAA/TAACTG 1 -- ng314Minor allele frequency- T:0.38EU EA WA 416
--
rs177127721,2
F,H57914615(+) CGGGGC/ATCCTC 1 -- ng517Minor allele frequency- A:0.01NA EU EA WA 562
rs9797671,2
H57912786(-) ACCTAG/AGTAAG 1 -- ng514Minor allele frequency- A:0.00EU EA WA 420
--
rs173596241,2
F58183588(+) ATATTA/GCCTGA 1 -- ng313Minor allele frequency- G:0.17NA 142
--
rs115506821,2
H57949284(+) ACTTTG/TACTAC 1 D/Y mis1 ese34Minor allele frequency- T:0.00EU EA WA 406
rs37972101,2
H58183285(-) ATAGCA/GTAATT 1 -- ng314Minor allele frequency- G:0.00EU EA WA 420
rs26626241,2
A,C,F,H,O58032183(-) TGCAAG/AGGAAC 1 -- int17Minor allele frequency- A:0.39NA EU EA WA 550
rs24320631,2
A,C,F,H,O58179214(-) ATGCTC/GATGCC 1 -- int17Minor allele frequency- G:0.34NA EU EA WA 560
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HapMap Linkage Disequilibrium images for RAB3C (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 612829

Human Genome Epidemiology Navigator: RAB3C (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10 PubMed articles for RAB3C gene:
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 115827 HGNC: 30269 AceView: RAB3C Ensembl:ENSG00000152932 euGenes: HUgn115827
ECgene: RAB3C H-InvDB: RAB3C
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

NameDescription
ATLAS Chromosomes in Cancer entry for RAB3C Genetics and Cytogenetics in Oncology and Haematology
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for RAB3C:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
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 Lentivirus-delivered shRNAs for RAB3C Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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 Recombinant & Natural Proteins  

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 Antibodies (RAB3C)
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 Custom Service for Mouse Mab
 Custom Service for Rabbit Pab from Full-length Protein
  
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 Recombinant Proteins
(Rab3A + Rab3B + Rab3C + Rab3D, Rab3C)
 Antibodies (Rab3A + Rab3B + Rab3C + Rab3D, Rab3C)
 Tagged/untagged cDNA clones
 Validated SYBR primer pairs
 Purified proteins from HEK293T cells
 Western blot validated antibodies
 shRNA in GFP-retroviral vector
 Search Tocris compounds for RAB3C




 Drugs for RAB3C
 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for RAB3C

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