Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RAB3C Gene

Aliases for RAB3C Gene

  • RAB3C, Member RAS Oncogene Family 2 3

External Ids for RAB3C Gene

Previous GeneCards Identifiers for RAB3C Gene

  • GC05P057849
  • GC05P057894
  • GC05P057914
  • GC05P054835

Summaries for RAB3C Gene

Entrez Gene Summary for RAB3C Gene

  • RAB proteins, such as RAB3C, are small GTPases implicated in the regulation of vesicular trafficking between membrane compartments (Cheng et al., 2002 [PubMed 12296628]).[supplied by OMIM, Jun 2009]

GeneCards Summary for RAB3C Gene

RAB3C (RAB3C, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include GTP binding. An important paralog of this gene is RAB37.

UniProtKB/Swiss-Prot for RAB3C Gene

  • Protein transport. Probably involved in vesicular traffic (By similarity).

Gene Wiki entry for RAB3C Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB3C Gene

Genomics for RAB3C Gene

Regulatory Elements for RAB3C Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RAB3C Gene

58,582,130 bp from pter
58,859,394 bp from pter
277,265 bases
Plus strand

Genomic View for RAB3C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAB3C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB3C Gene

Proteins for RAB3C Gene

  • Protein details for RAB3C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras-related protein Rab-3C
    Protein Accession:
    Secondary Accessions:

    Protein attributes for RAB3C Gene

    227 amino acids
    Molecular mass:
    25952 Da
    Quaternary structure:
    • Interacts with RIMS1, RIMS2, RPH3A and RPH3AL.

neXtProt entry for RAB3C Gene

Proteomics data for RAB3C Gene at MOPED

Post-translational modifications for RAB3C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB3C Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RAB3C Gene

Domains for RAB3C Gene

Gene Families for RAB3C Gene

  • RAB :RAB, member RAS oncogene

Suggested Antigen Peptide Sequences for RAB3C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q96E17
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB3C: view

Function for RAB3C Gene

Molecular function for RAB3C Gene

UniProtKB/Swiss-Prot Function:
Protein transport. Probably involved in vesicular traffic (By similarity).

Gene Ontology (GO) - Molecular Function for RAB3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IDA 24891604
GO:0005515 protein binding IPI 24891604
GO:0005525 GTP binding IEA --
GO:0031489 myosin V binding IPI 24006491
genes like me logo Genes that share ontologies with RAB3C: view
genes like me logo Genes that share phenotypes with RAB3C: view

Animal Models for RAB3C Gene

MGI Knock Outs for RAB3C:

Animal Model Products

miRNA for RAB3C Gene

miRTarBase miRNAs that target RAB3C

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAB3C

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for RAB3C Gene

Localization for RAB3C Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB3C Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

Jensen Localization Image for RAB3C Gene COMPARTMENTS Subcellular localization image for RAB3C gene
Compartment Confidence
plasma membrane 5
cytosol 3
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for RAB3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005737 cytoplasm --
GO:0005768 endosome IBA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with RAB3C: view

Pathways for RAB3C Gene

genes like me logo Genes that share pathways with RAB3C: view

Pathways by source for RAB3C Gene

1 Qiagen pathway for RAB3C Gene

Gene Ontology (GO) - Biological Process for RAB3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport IBA --
GO:0006904 vesicle docking involved in exocytosis IBA --
GO:0006913 nucleocytoplasmic transport --
GO:0007165 signal transduction --
genes like me logo Genes that share ontologies with RAB3C: view

Transcripts for RAB3C Gene

mRNA/cDNA for RAB3C Gene

Unigene Clusters for RAB3C Gene

RAB3C, member RAS oncogene family:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAB3C

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB3C Gene

No ASD Table

Relevant External Links for RAB3C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RAB3C Gene

mRNA expression in normal human tissues for RAB3C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB3C Gene

This gene is overexpressed in Brain - Hypothalamus (7.0), Brain - Anterior cingulate cortex (BA24) (6.9), Brain - Frontal Cortex (BA9) (6.0), Brain - Cortex (4.2), and Brain - Nucleus accumbens (basal ganglia) (4.1).

Protein differential expression in normal tissues for RAB3C Gene

This gene is overexpressed in Brain (26.8), Frontal cortex (15.4), and Peripheral blood mononuclear cells (8.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RAB3C Gene

SOURCE GeneReport for Unigene cluster for RAB3C Gene Hs.482173

mRNA Expression by UniProt/SwissProt for RAB3C Gene

Tissue specificity: Expressed in brain, placenta and lung.
genes like me logo Genes that share expressions with RAB3C: view

Expression partners for RAB3C Gene

In Situ Assay Products

Orthologs for RAB3C Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB3C Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RAB3C 35
  • 91.59 (n)
  • 95.87 (a)
RAB3C 36
  • 100 (a)
(Canis familiaris)
Mammalia RAB3C 35
  • 93.83 (n)
  • 98.24 (a)
RAB3C 36
  • 98 (a)
(Mus musculus)
Mammalia Rab3c 35
  • 89.43 (n)
  • 97.36 (a)
Rab3c 16
Rab3c 36
  • 97 (a)
(Pan troglodytes)
Mammalia RAB3C 35
  • 99.71 (n)
  • 100 (a)
RAB3C 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rab3c 35
  • 88.69 (n)
  • 97.36 (a)
(Monodelphis domestica)
Mammalia RAB3C 36
  • 96 (a)
(Gallus gallus)
Aves RAB3C 35
  • 85.32 (n)
  • 95.15 (a)
RAB3C 36
  • 95 (a)
(Anolis carolinensis)
Reptilia RAB3C 36
  • 92 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rab3c 35
  • 79.3 (n)
  • 92.07 (a)
(Danio rerio)
Actinopterygii rab3c 35
  • 76.04 (n)
  • 82.95 (a)
wufc17c11 35
rab3c 36
  • 79 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005255 35
  • 70.34 (n)
  • 80.73 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rab3 35
  • 68.2 (n)
  • 79.82 (a)
Rab3 36
  • 79 (a)
(Caenorhabditis elegans)
Secernentea rab-3 35
  • 65.92 (n)
  • 72.65 (a)
rab-3 36
  • 71 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 81 (a)
Species with no ortholog for RAB3C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB3C Gene

Gene Tree for RAB3C (if available)
Gene Tree for RAB3C (if available)

Paralogs for RAB3C Gene

Paralogs for RAB3C Gene

genes like me logo Genes that share paralogs with RAB3C: view

Variants for RAB3C Gene

Sequence variations from dbSNP and Humsavar for RAB3C Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs49960 -- 58,716,402(+) ATTCA(A/G)CCTAA intron-variant
rs49961 -- 58,716,655(+) TAGTT(A/T)GCTCG intron-variant
rs63710 -- 58,658,484(+) AATCA(A/G)TAGAA intron-variant
rs109371 -- 58,625,277(+) ATAAG(A/G)TAAGA intron-variant
rs149351 -- 58,701,297(+) cgccc(A/G)gccTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB3C Gene

Variant ID Type Subtype PubMed ID
esv1086361 CNV Insertion 17803354
esv1066632 CNV Insertion 17803354
esv1096603 CNV Insertion 17803354
esv2730219 CNV Deletion 23290073
esv1145647 CNV Insertion 17803354
esv2730220 CNV Deletion 23290073
esv2730221 CNV Deletion 23290073
esv2730222 CNV Deletion 23290073
nsv830311 CNV Gain 17160897
esv2588706 CNV Deletion 19546169
esv2730223 CNV Deletion 23290073
esv2124830 CNV Deletion 18987734
esv2730224 CNV Deletion 23290073
esv989220 CNV Deletion 20482838
esv1163457 CNV Deletion 17803354
nsv4845 CNV Loss 18451855
dgv109n17 CNV Loss 16327808
esv25926 CNV Loss 19812545
esv2664706 CNV Deletion 23128226
nsv328987 CNV Loss 16902084
nsv514306 CNV Loss 21397061
esv2422174 CNV Deletion 20811451
nsv442950 CNV CNV 18776908
esv27205 CNV Loss 19812545

Relevant External Links for RAB3C Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB3C Gene

Disorders for RAB3C Gene

Relevant External Links for RAB3C

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for RAB3C Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for RAB3C Gene

Publications for RAB3C Gene

  1. Cloning, mapping, and characterization of the human Rab3C gene. (PMID: 12296628) Cheng H. … Ma Y. (Biochem. Genet. 2002) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 48
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. (PMID: 21565611) Sang L. … Jackson P.K. (Cell 2011) 3

Products for RAB3C Gene

Sources for RAB3C Gene

Back to Top