Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



RAB3C Gene

protein-coding   GIFtS: 52
GCID: GC05P057914

RAB3C, Member RAS Oncogene Family

  Search for RAB3C
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
RAB3C, Member RAS Oncogene Family1 2
Ras-Related Protein Rab-3C2

External Ids:    HGNC: 302691   Entrez Gene: 1158272   Ensembl: ENSG000001529327   OMIM: 6128295   UniProtKB: Q96E173   

Export aliases for RAB3C gene to outside databases

Previous GC identifers: GC05P057849 GC05P057894 GC05P054835


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for RAB3C Gene:
RAB proteins, such as RAB3C, are small GTPases implicated in the regulation of vesicular trafficking between
membrane compartments (Cheng et al., 2002 (PubMed 12296628)).(supplied by OMIM, Jun 2009)

GeneCards Summary for RAB3C Gene:
RAB3C (RAB3C, member RAS oncogene family) is a protein-coding gene. GO annotations related to this gene include GTP binding. An important paralog of this gene is RAB10.

UniProtKB/Swiss-Prot: RAB3C_HUMAN, Q96E17
Function: Protein transport. Probably involved in vesicular traffic (By similarity)

Gene Wiki entry for RAB3C Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RAB3C gene promoter:
         GR   AML1a   FOXF2   GR-beta   MIF-1   E47   FOXC1   c-Myb   GR-alpha   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRAB3C promoter sequence
   Search Chromatin IP Primers for RAB3C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RAB3C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q13   Ensembl cytogenetic band:  5q11.2   HGNC cytogenetic band: 5q13

RAB3C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAB3C gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P057914:  view genomic region     (about GC identifiers)

Start:
57,878,048 bp from pter      End:
58,155,213 bp from pter
Size:
277,166 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RAB3C_HUMAN, Q96E17 (See protein sequence)
Recommended Name: Ras-related protein Rab-3C  
Size: 227 amino acids; 25952 Da
Subunit: Interacts with RIMS1, RIMS2, RPH3A and RPH3AL (By similarity)

Explore the universe of human proteins at neXtProt for RAB3C: NX_Q96E17

Explore proteomics data for RAB3C at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RAB3C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_612462.1  
    ENSEMBL proteins: 
     ENSP00000282878  

    RAB3C Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for RAB3C
    OriGene Protein Over-expression Lysate for RAB3C
    OriGene MassSpec for RAB3C
    OriGene Custom Protein Services for RAB3C
    GenScript Custom Purified and Recombinant Proteins Services for RAB3C
    Novus Biologicals RAB3C Protein
    Novus Biologicals RAB3C Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RAB3C

     
    Search eBioscience for Proteins for RAB3C 

    RAB3C Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for RAB3C
    OriGene Custom Antibody Services for RAB3C
    Novus Biologicals RAB3C Antibodies
    Abcam antibodies for RAB3C
    Cloud-Clone Corp. Antibodies for RAB3C
    ThermoFisher Antibody for RAB3C
    LSBio Antibodies in human, mouse, rat for RAB3C

    RAB3C Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RAB3C
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RAB3C
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RAB3C
    Cloud-Clone Corp. CLIAs for RAB3C
    Search eBioscience for ELISAs for RAB3C 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    RAB: RAB, member RAS oncogene

    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR003579 Small_GTPase_Rab_type
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q96E17

    ProtoNet protein and cluster: Q96E17

    1 Blocks protein domain: IPB001806 Transforming protein P21 RAS signature

    UniProtKB/Swiss-Prot: RAB3C_HUMAN, Q96E17
    Similarity: Belongs to the small GTPase superfamily. Rab family


    Find genes that share domains with RAB3C           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RAB3C_HUMAN, Q96E17
    Function: Protein transport. Probably involved in vesicular traffic (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity ----
    GO:0005515protein binding ----
    GO:0005525GTP binding IEA--
         
    Find genes that share ontologies with RAB3C           About GenesLikeMe


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rab3c):
     behavior/neurological  growth/size/body  homeostasis/metabolism  mortality/aging  nervous system 
     normal  respiratory system 

    Find genes that share phenotypes with RAB3C           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Rab3ctm1Sud for RAB3C

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RAB3C
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RAB3C

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RAB3C
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RAB3C

    miRNA
    Products:
        
    miRTarBase miRNAs that target RAB3C:
    hsa-mir-335-5p (MIRT016896)

    Block miRNA regulation of human, mouse, rat RAB3C using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate RAB3C
    SwitchGear 3'UTR luciferase reporter plasmidRAB3C 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RAB3C
    Predesigned siRNA for gene silencing in human, mouse, rat RAB3C

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RAB3C

    Clone
    Products:
         
    OriGene clones in human, mouse for RAB3C (see all 8)
    OriGene ORF clones in mouse, rat for RAB3C
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RAB3C (NM_138453)
    Sino Biological Human cDNA Clone for RAB3C
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAB3C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB3C

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RAB3C
    Browse ESI BIO Cell Lines and PureStem Progenitors for RAB3C 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB3C


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    RAB3C_HUMAN, Q96E17: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol3
    nucleus2
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0005829cytosol IEA--
    GO:0005886plasma membrane IEA--

    Find genes that share ontologies with RAB3C           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for RAB3C About    
    See pathways by source

    SuperPathContained pathways About
    1Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions0.36

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for RAB3C
        Epithelial Tight Junctions



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RAB3C
    Interactions:

        GeneGlobe Interaction Network for RAB3C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for RAB3C (Q96E173 ENSP000002828784) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RIMS2Q9UQ263, ENSP000003862284I2D: score=5 STRING: ENSP00000390665 STRING: ENSP00000386228
    RPH3ALQ9UNE23, ENSP000003192104I2D: score=4 STRING: ENSP00000319210
    RIMS1Q86UR53, ENSP000002648394I2D: score=3 STRING: ENSP00000264839
    RPH3AQ9Y2J03, ENSP000004132544I2D: score=2 STRING: ENSP00000413254
    AXIN2Q9Y2T13I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process ----
    GO:0006886intracellular protein transport ----
    GO:0006913nucleocytoplasmic transport ----
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction IEA--

    Find genes that share ontologies with RAB3C           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RAB3C



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for RAB3C gene: 
    NM_138453.2  

    Unigene Cluster for RAB3C:

    RAB3C, member RAS oncogene family
    Hs.482173  [show with all ESTs]
    Unigene Representative Sequence: BC013033
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000513316 ENST00000282878(uc003jrp.3) ENST00000507977 ENST00000381158

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RAB3C using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate RAB3C
    SwitchGear 3'UTR luciferase reporter plasmidRAB3C 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RAB3C
    Predesigned siRNA for gene silencing in human, mouse, rat RAB3C
    Clone
    Products:
         
    OriGene clones in human, mouse for RAB3C (see all 8)
    OriGene ORF clones in mouse, rat for RAB3C
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RAB3C (NM_138453)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAB3C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB3C
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for RAB3C
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RAB3C
      QuantiTect SYBR Green Assays in human, mouse, rat RAB3C
      QuantiFast Probe-based Assays in human, mouse, rat RAB3C

    Additional mRNA sequence: 

    AY026936.1 BC013033.2 

    2 DOTS entries:

    DT.205486  DT.100773169 

    Selected AceView cDNA sequences (see all 28):

    BG181521 BP360270 BM683101 BC013033 BX112487 NM_138453 AY026936 AA868463 
    AI364134 BP361193 BM069462 BF438170 BE263328 CK904542 CK904541 BX394661 
    BP362717 AI278619 AA121806 BI670306 BG199104 BM054660 BM054844 AL706809 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    RAB3C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RAB3C Expression
    About this image


    RAB3C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Endothelial Cells Blood Brain Barrier
             Cerebral Cortex
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     NULL (Uncategorized)
             Neural rosettes
     
     Endothelium (Cardiovascular System)
             Endothelial Cells Blood Brain Barrier
     
     Neurons
             Adult Dopaminergic Neurons Substantia Nigra pars Compacta
    RAB3C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RAB3C Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.482173

    UniProtKB/Swiss-Prot: RAB3C_HUMAN, Q96E17
    Tissue specificity: Expressed in brain, placenta and lung

        Custom PCR Arrays for RAB3C
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for RAB3C
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RAB3C
    QuantiTect SYBR Green Assays in human, mouse, rat RAB3C
    QuantiFast Probe-based Assays in human, mouse, rat RAB3C
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB3C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for RAB3C gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rab3c1 , 5 RAB3C, member RAS oncogene family1, 5 89.43(n)1
    97.36(a)1
      13 (61.19 cM)5
    672951  NM_023852.51  NP_076341.11 
     1100541875 
    chicken
    (Gallus gallus)
    Aves RAB3C1 RAB3C, member RAS oncogene family 85.32(n)
    95.15(a)
      770370  XM_003642948.2  XP_003642996.1 
    lizard
    (Anolis carolinensis)
    Reptilia RAB3C6
    RAB3C, member RAS oncogene family
    92(a)
    1 ↔ 1
    2(9922132-9997594)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rab3c1 RAB3C, member RAS oncogene family 79.3(n)
    92.07(a)
      100496123  XM_002938179.2  XP_002938225.2 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc17c112 Transcribed sequence with moderate similarity to protein more 82.42(n)    CK396641.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rab31 Rab3 68.2(n)
    79.82(a)
      36127  NM_078963.2  NP_523687.1 
    worm
    (Caenorhabditis elegans)
    Secernentea rab-31 rab-3 65.92(n)
    72.65(a)
      173971  NM_001026802.2  NP_001021973.1 


    ENSEMBL Gene Tree for RAB3C (if available)
    TreeFam Gene Tree for RAB3C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for RAB3C gene
    RAB102  RAB3B2  RAB262  RAB8A2  RAB3D2  RAB372  RAB3A2  RAB8B2  
    RAB1B2  RAB122  RAB1A2  RAB132  
    Selected SIMAP similar genes for RAB3C using alignment to 2 protein entries:     RAB3C_HUMAN (see all proteins) (see all similar genes):
    RAB3A    RAB3B    RAB3D    RAB8B    RAB13    RAB8A
    RAB10    RAB15    RAB26    RAB39B    RAB27A    RAB37
    RAB11A    RAB11B    RAB23    RAB41    RAB30    DKFZp686J07132

    Find genes that share paralogs with RAB3C           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for RAB3C (see all 5247)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs343520861,2
    C--57872107(+) ACTCTT/-TTTTT 1 -- int11Minor allele frequency- -:0.50NA 2
    rs1423903001,2
    C--57876973(+) AGGCAC/TGCTCC 1 -- us2k10--------
    rs791602181,2
    C,F--57877020(+) TAAAAA/CCTACT 1 -- us2k12Minor allele frequency- C:0.09NA EA 240
    rs9797671,2
    H--57877029(-) ACCTAG/AGTAAG 1 -- us2k14Minor allele frequency- A:0.00NS EA 420
    rs1921413921,2
    --57877141(+) AGGTTA/CCCAAT 1 -- us2k10--------
    rs762806071,2
    --57877151(+) TATTAG/TACTGT 1 -- us2k10--------
    rs1846865141,2
    --57877551(+) GATTTA/GCTGGA 1 -- us2k10--------
    rs1885133711,2
    --57877642(+) CTGACA/GGGAAA 1 -- us2k10--------
    rs1416069411,2
    --57877773(+) TAATAC/GAGGTC 1 -- us2k10--------
    rs1812833201,2
    --57877817(+) CCGGTA/GATGAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RAB3C (57878048 - 58128048 bp, first 250kb of RAB3C)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for RAB3C (see all 24):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2730222CNV Deletion23290073
    esv2664706CNV Deletion23128226
    esv2730220CNV Deletion23290073
    esv2730221CNV Deletion23290073
    esv989220CNV Deletion20482838
    esv2422174CNV Deletion20811451
    esv1163457CNV Deletion17803354
    esv2730219CNV Deletion23290073
    esv2730224CNV Deletion23290073
    esv2588706CNV Deletion19546169

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RAB3C
    DNA2.0 Custom Variant and Variant Library Synthesis for RAB3C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 612829    OMIM disorders: --


    Find genes that share disorders with RAB3C           About GenesLikeMe

    Genetic Association Database (GAD): RAB3C
    Human Genome Epidemiology (HuGE) Navigator: RAB3C (2 documents)

    Export disorders for RAB3C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for RAB3C gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with RAB3C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, mapping, and characterization of the human Rab3C gene. (PubMed id 12296628)1, 2, 3, 9 Cheng H.... Ma Y. (Biochem. Genet. 2002)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PubMed id 23382691)1 Lauc G....Rudan I. (PLoS Genet. 2013)
    6. Large-scale genotyping identifies 41 new loci associated with breast cancer risk. (PubMed id 23535729)1 Michailidou K....Easton D.F. (Nat. Genet. 2013)
    7. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. (PubMed id 21565611)1 Sang L.... Jackson P.K. (Cell 2011)
    8. The GTPase Rab3b/3c-positive recycling vesicles are involved in cross-presentation in dendritic cells. (PubMed id 19717423)1 Zou L....Wu Y. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    10. Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells. (PubMed id 15159548)1 Matsumoto M....Seino S. (Proc. Natl. Acad. Sci. U.S.A. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 115827 HGNC: 30269 AceView: RAB3C Ensembl:ENSG00000152932 euGenes: HUgn115827
    ECgene: RAB3C H-InvDB: RAB3C

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for RAB3C Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAB3C Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for RAB3C gene:
    Search GeneIP for patents involving RAB3C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for RAB3C   OriGene RNAi products in human, mouse, rat for RAB3C  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for RAB3C  
     OriGene MassSpec something-or-other for RAB3C   OriGene clones in human, mouse for RAB3C  
     OriGene qSTAR qPCR primer pairs in human, mouse for RAB3C   OriGene Purified Protein for RAB3C  
     OriGene ORF clones in mouse, rat for RAB3C   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RAB3C   OriGene Custom Protein Services for RAB3C  

     
     
     Block miRNA regulation of human, mouse, rat RAB3C using miScript Target Protectors SeqTarget long-range PCR primers for resequencing RAB3C
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RAB3C Predesigned siRNA for gene silencing in human, mouse, rat RAB3C
     QuantiFast Probe-based Assays in human, mouse, rat RAB3C QuantiTect SYBR Green Assays in human, mouse, rat RAB3C
     Custom PCR Arrays for RAB3C Search Chromatin IP Primers for RAB3C
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RAB3C  GeneGlobe Interaction Network for RAB3C
     Regulatory tfbs in RAB3C promoter
     GenScript Custom Purified and Recombinant Proteins Services for RAB3C GenScript cDNA clones with any tag delivered in your preferred vector for RAB3C
     GenScript Custom Assay Services for RAB3C GenScript Custom overexpressing Cell Line Services for RAB3C
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for RAB3C
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for RAB3C
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     RAB3C antibodies
     RAB3C proteins
     RAB3C lysates
     Antibodies for RAB3C
     See all of Abcam's Antibodies, Kits and Proteins for RAB3C
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for RAB3C
     Antibodies for RAB3C
     ELISAs for RAB3C
     CLIAs for RAB3C



     Browse ESI BIO Cell Lines and PureStem Progenitors for RAB3C
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB3C
     SwitchGear 3'UTR luciferase reporter plasmids for RAB3C
     SwitchGear Promoter luciferase reporter plasmids for RAB3C
     ThermoFisher Antibody for RAB3C
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB3C
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RAB3C
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RAB3C
     LSBio Antibodies in human, mouse, rat for RAB3C
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for RAB3C
      Search eBioscience for proteins for RAB3C
      Search eBioscience for elisas for RAB3C
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RAB3C gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4