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Aliases for RAB3C Gene

Aliases for RAB3C Gene

  • RAB3C, Member RAS Oncogene Family 2 3 5

External Ids for RAB3C Gene

Previous GeneCards Identifiers for RAB3C Gene

  • GC05P057849
  • GC05P057894
  • GC05P057914
  • GC05P054835

Summaries for RAB3C Gene

Entrez Gene Summary for RAB3C Gene

  • This gene is a member of the RAS oncogene family and encodes a small GTPase. Other similar small GTPases are known to be involved in vesicle trafficking, and the encoded protein was shown to play a role in recycling phagocytosed MHC class 1 complexes to the cell surface. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

GeneCards Summary for RAB3C Gene

RAB3C (RAB3C, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include GTP binding and myosin V binding. An important paralog of this gene is RAB37.

UniProtKB/Swiss-Prot for RAB3C Gene

  • Protein transport. Probably involved in vesicular traffic (By similarity).

Gene Wiki entry for RAB3C Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB3C Gene

Genomics for RAB3C Gene

Regulatory Elements for RAB3C Gene

Enhancers for RAB3C Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RAB3C on UCSC Golden Path with GeneCards custom track

Promoters for RAB3C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RAB3C on UCSC Golden Path with GeneCards custom track

Genomic Location for RAB3C Gene

58,582,127 bp from pter
58,859,394 bp from pter
277,268 bases
Plus strand

Genomic View for RAB3C Gene

Genes around RAB3C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB3C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB3C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB3C Gene

Proteins for RAB3C Gene

  • Protein details for RAB3C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras-related protein Rab-3C
    Protein Accession:

    Protein attributes for RAB3C Gene

    227 amino acids
    Molecular mass:
    25952 Da
    Quaternary structure:
    • Interacts with RIMS1, RIMS2, RPH3A and RPH3AL.

neXtProt entry for RAB3C Gene

Proteomics data for RAB3C Gene at MOPED

Post-translational modifications for RAB3C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB3C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RAB3C Gene

Domains & Families for RAB3C Gene

Gene Families for RAB3C Gene

Suggested Antigen Peptide Sequences for RAB3C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Rab family.
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB3C: view

Function for RAB3C Gene

Molecular function for RAB3C Gene

UniProtKB/Swiss-Prot Function:
Protein transport. Probably involved in vesicular traffic (By similarity).
genes like me logo Genes that share phenotypes with RAB3C: view

Animal Models for RAB3C Gene

MGI Knock Outs for RAB3C:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RAB3C Gene

Localization for RAB3C Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB3C Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

Jensen Localization Image for RAB3C Gene COMPARTMENTS Subcellular localization image for RAB3C gene
Compartment Confidence
cytosol 5
plasma membrane 4
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for RAB3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA --
GO:0008021 synaptic vesicle IEA --
GO:0048471 perinuclear region of cytoplasm IDA 19717423
genes like me logo Genes that share ontologies with RAB3C: view

Pathways & Interactions for RAB3C Gene

genes like me logo Genes that share pathways with RAB3C: view

Pathways by source for RAB3C Gene

1 Qiagen pathway for RAB3C Gene

Gene Ontology (GO) - Biological Process for RAB3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006913 nucleocytoplasmic transport IEA --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with RAB3C: view

No data available for SIGNOR curated interactions for RAB3C Gene

Drugs & Compounds for RAB3C Gene

No Compound Related Data Available

Transcripts for RAB3C Gene

Unigene Clusters for RAB3C Gene

RAB3C, member RAS oncogene family:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAB3C Gene

No ASD Table

Relevant External Links for RAB3C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RAB3C Gene

mRNA expression in normal human tissues for RAB3C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB3C Gene

This gene is overexpressed in Brain - Hypothalamus (x7.0), Brain - Anterior cingulate cortex (BA24) (x6.9), Brain - Frontal Cortex (BA9) (x6.0), Brain - Cortex (x4.2), and Brain - Nucleus accumbens (basal ganglia) (x4.1).

Protein differential expression in normal tissues from HIPED for RAB3C Gene

This gene is overexpressed in Brain (26.8), Frontal cortex (15.4), and Peripheral blood mononuclear cells (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RAB3C Gene

SOURCE GeneReport for Unigene cluster for RAB3C Gene Hs.482173

mRNA Expression by UniProt/SwissProt for RAB3C Gene

Tissue specificity: Expressed in brain, placenta and lung.
genes like me logo Genes that share expression patterns with RAB3C: view

Protein tissue co-expression partners for RAB3C Gene

- Elite partner

Primer Products

Orthologs for RAB3C Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB3C Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RAB3C 35
  • 91.59 (n)
  • 95.87 (a)
RAB3C 36
  • 100 (a)
(Canis familiaris)
Mammalia RAB3C 35
  • 93.83 (n)
  • 98.24 (a)
RAB3C 36
  • 98 (a)
(Mus musculus)
Mammalia Rab3c 35
  • 89.43 (n)
  • 97.36 (a)
Rab3c 16
Rab3c 36
  • 97 (a)
(Pan troglodytes)
Mammalia RAB3C 35
  • 99.71 (n)
  • 100 (a)
RAB3C 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rab3c 35
  • 88.69 (n)
  • 97.36 (a)
(Monodelphis domestica)
Mammalia RAB3C 36
  • 96 (a)
(Gallus gallus)
Aves RAB3C 35
  • 85.32 (n)
  • 95.15 (a)
RAB3C 36
  • 95 (a)
(Anolis carolinensis)
Reptilia RAB3C 36
  • 92 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rab3c 35
  • 79.3 (n)
  • 92.07 (a)
(Danio rerio)
Actinopterygii rab3c 35
  • 76.04 (n)
  • 82.95 (a)
wufc17c11 35
rab3c 36
  • 79 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005255 35
  • 70.34 (n)
  • 80.73 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rab3 35
  • 68.2 (n)
  • 79.82 (a)
Rab3 36
  • 79 (a)
(Caenorhabditis elegans)
Secernentea rab-3 35
  • 65.92 (n)
  • 72.65 (a)
rab-3 36
  • 71 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 81 (a)
Species with no ortholog for RAB3C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB3C Gene

Gene Tree for RAB3C (if available)
Gene Tree for RAB3C (if available)

Paralogs for RAB3C Gene

genes like me logo Genes that share paralogs with RAB3C: view

Variants for RAB3C Gene

Sequence variations from dbSNP and Humsavar for RAB3C Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs716536 -- 58,661,847(+) ACAGA(A/G)GGGTT intron-variant
rs720084 -- 58,743,814(+) TTCCC(A/G)AAGTA intron-variant
rs753219 -- 58,670,688(-) CGGGC(A/G)GACAG intron-variant
rs753220 -- 58,670,683(-) GGACA(C/G)TCTAA intron-variant
rs829997 -- 58,857,881(-) CTTTT(C/T)GTTAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RAB3C Gene

Variant ID Type Subtype PubMed ID
esv1086361 CNV Insertion 17803354
esv1066632 CNV Insertion 17803354
esv1096603 CNV Insertion 17803354
esv2730219 CNV Deletion 23290073
esv1145647 CNV Insertion 17803354
esv2730220 CNV Deletion 23290073
esv2730221 CNV Deletion 23290073
esv2730222 CNV Deletion 23290073
nsv830311 CNV Gain 17160897
esv2588706 CNV Deletion 19546169
esv2730223 CNV Deletion 23290073
esv2124830 CNV Deletion 18987734
esv2730224 CNV Deletion 23290073
esv989220 CNV Deletion 20482838
esv1163457 CNV Deletion 17803354
nsv4845 CNV Loss 18451855
dgv109n17 CNV Loss 16327808
esv25926 CNV Loss 19812545
esv2664706 CNV Deletion 23128226
nsv328987 CNV Loss 16902084
nsv514306 CNV Loss 21397061
esv2422174 CNV Deletion 20811451
nsv442950 CNV CNV 18776908
esv27205 CNV Loss 19812545

Variation tolerance for RAB3C Gene

Residual Variation Intolerance Score: 34.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.29; 6.55% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RAB3C Gene

Disorders for RAB3C Gene

Relevant External Links for RAB3C

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RAB3C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB3C Gene

Publications for RAB3C Gene

  1. Cloning, mapping, and characterization of the human Rab3C gene. (PMID: 12296628) Cheng H. … Ma Y. (Biochem. Genet. 2002) 2 3 4 23 67
  2. Rab18 and a Rab18 GEF complex are required for normal ER structure. (PMID: 24891604) Gerondopoulos A. … Barr F.A. (J. Cell Biol. 2014) 3
  3. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PMID: 23382691) Lauc G. … Rudan I. (PLoS Genet. 2013) 3
  4. Large-scale genotyping identifies 41 new loci associated with breast cancer risk. (PMID: 23535729) Michailidou K. … Easton D.F. (Nat. Genet. 2013) 3
  5. Identification and characterization of multiple novel Rab-myosin Va interactions. (PMID: 24006491) Lindsay A.J. … Goud B. (Mol. Biol. Cell 2013) 3

Products for RAB3C Gene

Sources for RAB3C Gene