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Aliases & Descriptions for RAB3C
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| | | Descriptions |
|---|
| RAB3C, member RAS oncogene family 2 |
|
| | Search outside databases for aliases for RAB3C genePrevious GC identifers: GC05P057849 GC05P057894 |
Summaries for RAB3C(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: RAB3C_HUMAN, Q96E17Function: Protein transport. Probably involved in vesicular traffic (By similarity)Gene Wiki entry for RAB3C |
Genomic Location for RAB3C
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the RAB3C gene 
Entrez Gene cytogenetic band: 5q13 Ensembl cytogenetic band: 5q11.2 HGNC cytogenetic band: 5q13RAB3C Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P057914:
(about GC identifiers)
Start:
|
57,914,696 bp from pter |
End:
|
58,183,163 bp from pter |
Size:
|
268,468 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000005.8 NT_006713.14
| Proteins for RAB3C
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: RAB3C_HUMAN, Q96E17 (See
protein sequence)Recommended Name: Ras-related protein Rab-3C Size: 227 amino acids; 25952 Da
Subunit: Binds RIMS1 (By similarity)
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)REFSEQ proteins: NP_612462.1
ENSEMBL proteins: ENSP00000282878 ENSP00000370550
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: RAB3C 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for RAB3C: Assays for RAB3C: | Protein
Domains/ Families for RAB3C(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q96E17
ProtoNet protein and cluster: Q96E17 1 Blocks protein family: IPB001806 Transforming protein P21 RAS signature
UniProtKB/Swiss-Prot: RAB3C_HUMAN, Q96E17Similarity: Belongs to the small GTPase superfamily. Rab family | Gene Function for RAB3C
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_138453
Applied Biosystems Silencer® siRNAs for RAB3C
Sigma-Aldrich siRNA for RAB3C  Sigma-Aldrich shRNA for RAB3C  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_138453                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_138453                                  untagged cDNA clones in CMV expression vector (see all 2): NM_138453 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_138453
UniProtKB/Swiss-Prot: RAB3C_HUMAN, Q96E17Function: Protein transport. Probably involved in vesicular traffic (By similarity)7 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Rab3c):
2 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000166 | nucleotide binding |
IEA | -- | | GO:0005525 | GTP binding |
IEA | -- | About this table | Pathways & Interactions for RAB3C
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for RAB3C 
5 Interacting proteins for RAB3C (ENSP000003705503) via UniProtKB, MINT, and/or STRINGAbout this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007264 | small GTPase mediated signal transduction |
IEA | -- | | GO:0015031 | protein transport |
IEA | -- | About this table
|
Drugs & Compounds for RAB3C(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|  |
Enzo Life Sciences drugs & compounds for RAB3C |
Browse Tocris compounds for RAB3C
|
Transcripts for RAB3C(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_138453
Sigma-Aldrich siRNA for RAB3C  Sigma-Aldrich shRNA for RAB3C  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_138453 REFSEQ mRNAs for RAB3C gene: NM_138453.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_138453               OriGene GFP tagged cDNA clone in CMV expression vector: NM_138453                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_138453                                  untagged cDNA clones in CMV expression vector (see all 2): NM_138453  Additional cDNA sequence: AY026936.1 BC013033.2 2 DOTS entries: DT.205486 DT.100773169 24/28 AceView cDNA sequences (see all 28
):BX112487 BP360270 BM683101 BG181521 BC013033 NM_138453 AA868463 CK904542 BX394661 BP362717 BM069462 AY026936 BI670306 AI278619 CK904541 BE263328 BF438170 AA121806 AI364134 BP361193 BM054660 AL706809 BM054844 BG199104
highest scoring ESTs for RAB3C:AI278619 AA121806 AI364134 AL706809 AY026936 BC013033 BE263328 BF438170 BG055348 BG181521 Unigene Cluster for RAB3C: RAB3C, member RAS oncogene family Hs.482173 [show with all ESTs]Unigene Representative Sequence: BC013033
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations: ENST00000282878
ENST00000381158
|
Expression for RAB3C
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| RAB3C expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for RAB3C
1 / 2 / 3 3 probe-sets matching RAB3C gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.482173
|
Orthologs for RAB3C
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for RAB3C gene from 5/9 species (see all 9
)
About this table Species with no ortholog for RAB3C
ENSEMBL Gene Tree for RAB3C | Paralogs for RAB3C(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for RAB3C gene
- RAB3A2 RAB3B2 RAB122 RAB3D2
|
SNPs/Variants for RAB3C(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for RAB3C (up to first 250kb)
|
Disorders & Mutations for RAB3C
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 612829
Human Genome Epidemiology Navigator: RAB3C (1 document)
|
Medical News for RAB3C(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for RAB3C (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10 PubMed articles for RAB3C gene:- Cloning, mapping, and characterization of the human Rab3C gene. (PubMed id 12296628)1, 2, 3 Cheng H....Ma Y. (2002)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)3 Trynka G....Wijmenga C. (2009)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)3 Barbe L....Andersson-Svahn H. (2008)
- Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells. (PubMed id 15159548)3 Matsumoto M....Seino S. (2004)
- Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2. (PubMed id 12578829)3 Fukuda M. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- Localization versus function of Rab3 proteins. Evidence for a common regulatory role in controlling fusion. (PubMed id 12167638)3 Schluter O.M....Sudhof T.C. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )4 Aoki H.... Hino O. (2000)
- Insulin-dependent translocation of the small GTP-binding protein rab3C in cardiac muscle: studies on insulin-resistant Zucker rats. (PubMed id 8543030)3 Uphues I....Eckel J. (1995)
|
Search for RAB3C
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing RAB3C
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing RAB3C
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RAB3C(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for RAB3C(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for RAB3C:

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Incremental update: 13 Oct 2009
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