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Aliases for RAB3B Gene

Aliases for RAB3B Gene

  • RAB3B, Member RAS Oncogene Family 2 3

External Ids for RAB3B Gene

Summaries for RAB3B Gene

GeneCards Summary for RAB3B Gene

RAB3B (RAB3B, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Tight junction. GO annotations related to this gene include GTP binding. An important paralog of this gene is RAB37.

UniProtKB/Swiss-Prot for RAB3B Gene

  • Protein transport. Probably involved in vesicular traffic (By similarity).

Gene Wiki entry for RAB3B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB3B Gene

Genomics for RAB3B Gene

Genomic Location for RAB3B Gene

Start:
51,907,956 bp from pter
End:
51,990,764 bp from pter
Size:
82,809 bases
Orientation:
Minus strand

Genomic View for RAB3B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAB3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB3B Gene

Regulatory Elements for RAB3B Gene

Proteins for RAB3B Gene

  • Protein details for RAB3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20337-RAB3B_HUMAN
    Recommended name:
    Ras-related protein Rab-3B
    Protein Accession:
    P20337
    Secondary Accessions:
    • Q5VUL2
    • Q9BSI1

    Protein attributes for RAB3B Gene

    Size:
    219 amino acids
    Molecular mass:
    24758 Da
    Quaternary structure:
    • Interacts with RIMS1, RIMS2, RPH3A and RPH3AL.

    Three dimensional structures from OCA and Proteopedia for RAB3B Gene

neXtProt entry for RAB3B Gene

Proteomics data for RAB3B Gene at MOPED

Post-translational modifications for RAB3B Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys72

Other Protein References for RAB3B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RAB3B Gene

Domains for RAB3B Gene

Gene Families for RAB3B Gene

HGNC:
  • RAB :RAB, member RAS oncogene

UniProtKB/Swiss-Prot:

RAB3B_HUMAN
Family:
  • Belongs to the small GTPase superfamily. Rab family.:
    • P20337
genes like me logo Genes that share domains with RAB3B: view

Function for RAB3B Gene

Molecular function for RAB3B Gene

GENATLAS Biochemistry: RAB3B,Ras oncogene superfamily member,involved in calcium regulated exocytosis
UniProtKB/Swiss-Prot Function: Protein transport. Probably involved in vesicular traffic (By similarity).

Gene Ontology (GO) - Molecular Function for RAB3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IDA 24891604
GO:0005515 protein binding IPI 24891604
GO:0005525 GTP binding IEA --
GO:0019003 GDP binding IDA 22321395
GO:0031489 myosin V binding IPI 24006491
genes like me logo Genes that share ontologies with RAB3B: view
genes like me logo Genes that share phenotypes with RAB3B: view

Animal Models for RAB3B Gene

MGI Knock Outs for RAB3B:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for RAB3B Gene

Localization for RAB3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB3B Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB3B Gene COMPARTMENTS Subcellular localization image for RAB3B gene
Compartment Confidence
plasma membrane 5
cytosol 3

Gene Ontology (GO) - Cellular Components for RAB3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005737 cytoplasm IDA 20807725
GO:0005768 endosome IBA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with RAB3B: view

Pathways for RAB3B Gene

genes like me logo Genes that share pathways with RAB3B: view

Pathways by source for RAB3B Gene

1 Qiagen pathway for RAB3B Gene
1 KEGG pathway for RAB3B Gene

Gene Ontology (GO) - Biological Process for RAB3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport IBA --
GO:0006904 vesicle docking involved in exocytosis IBA --
GO:0006913 nucleocytoplasmic transport --
GO:0007165 signal transduction --
genes like me logo Genes that share ontologies with RAB3B: view

Transcripts for RAB3B Gene

mRNA/cDNA for RAB3B Gene

Unigene Clusters for RAB3B Gene

RAB3B, member RAS oncogene family:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAB3B Gene

No ASD Table

Relevant External Links for RAB3B Gene

GeneLoc Exon Structure for
RAB3B
ECgene alternative splicing isoforms for
RAB3B

Expression for RAB3B Gene

mRNA expression in normal human tissues for RAB3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB3B Gene

This gene is overexpressed in Brain - Hypothalamus (8.7), Pituitary (7.1), and Brain - Amygdala (5.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB3B Gene

SOURCE GeneReport for Unigene cluster for RAB3B Gene Hs.123072

genes like me logo Genes that share expressions with RAB3B: view

Orthologs for RAB3B Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB3B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB3B 36
  • 99.54 (n)
  • 99.54 (a)
RAB3B 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RAB3B 36
  • 92.85 (n)
  • 97.72 (a)
RAB3B 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAB3B 36
  • 91.78 (n)
  • 97.26 (a)
RAB3B 37
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rab3b 36
  • 89.35 (n)
  • 97.26 (a)
Rab3b 16
Rab3b 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAB3B 37
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rab3b 36
  • 88.58 (n)
  • 95.89 (a)
chicken
(Gallus gallus)
Aves RAB3B 36
  • 77.02 (n)
  • 83.11 (a)
RAB3B 37
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAB3B 37
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rab3b 36
  • 75.42 (n)
  • 82.95 (a)
zebrafish
(Danio rerio)
Actinopterygii rab3b 36
  • 71.23 (n)
  • 81.13 (a)
rab3b 37
  • 80 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Rab3 37
  • 76 (a)
OneToMany
Rab3 38
  • 76 (a)
worm
(Caenorhabditis elegans)
Secernentea rab-3 37
  • 68 (a)
OneToMany
rab-3 38
  • 75 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4921 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 75 (a)
OneToMany
Species with no ortholog for RAB3B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB3B Gene

ENSEMBL:
Gene Tree for RAB3B (if available)
TreeFam:
Gene Tree for RAB3B (if available)

Paralogs for RAB3B Gene

Paralogs for RAB3B Gene

genes like me logo Genes that share paralogs with RAB3B: view

Variants for RAB3B Gene

Sequence variations from dbSNP and Humsavar for RAB3B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs11212 -- 51,908,115(+) ACTGT(A/G)TATAT utr-variant-3-prime
rs12730 -- 51,908,222(-) CATGC(G/T)TTTTT utr-variant-3-prime
rs933084 -- 51,987,106(-) TTTTC(A/T)CAGCC intron-variant
rs970739 -- 51,969,553(+) AGTAT(G/T)AGCAA intron-variant
rs1024311 -- 51,991,487(+) ATTTT(G/T)ACACA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RAB3B Gene

Variant ID Type Subtype PubMed ID
nsv829837 CNV Loss 17160897
nsv843 CNV Insertion 18451855
nsv829848 CNV Loss 17160897
nsv509246 CNV Insertion 20534489
esv1010825 CNV Insertion 20482838
esv1693930 CNV Insertion 17803354
esv24521 CNV Loss 19812545

Relevant External Links for RAB3B Gene

HapMap Linkage Disequilibrium report
RAB3B

Disorders for RAB3B Gene

No disorders were found for RAB3B Gene.

No data available for UniProtKB/Swiss-Prot for RAB3B Gene

Publications for RAB3B Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  2. The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion. (PMID: 2501306) Zahraoui A. … Tavitian A. (J. Biol. Chem. 1989) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. High-throughput mapping of a dynamic signaling network in mammalian cells. (PMID: 15761153) Barrios-Rodiles M. … Wrana J.L. (Science 2005) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for RAB3B Gene

  • Addgene plasmids for RAB3B

Sources for RAB3B Gene

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