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Aliases for RAB3B Gene

Aliases for RAB3B Gene

  • RAB3B, Member RAS Oncogene Family 2 3 5

External Ids for RAB3B Gene

Previous GeneCards Identifiers for RAB3B Gene

  • GC01M051273
  • GC01M051732
  • GC01M051754
  • GC01M052096
  • GC01M052373
  • GC01M050490

Summaries for RAB3B Gene

GeneCards Summary for RAB3B Gene

RAB3B (RAB3B, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Tight junction and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB3C.

UniProtKB/Swiss-Prot for RAB3B Gene

  • Protein transport. Probably involved in vesicular traffic (By similarity).

Gene Wiki entry for RAB3B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB3B Gene

Genomics for RAB3B Gene

Regulatory Elements for RAB3B Gene

Enhancers for RAB3B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F052208 0.9 ENCODE 10.5 -219.3 -219291 3.0 HDGF HDAC1 ATF1 PKNOX1 TBL1XR1 NFRKB ZBTB40 GATA2 FOS ETV6 CC2D1B RAB3B PIR48588 GC01P052251
GH01F051896 1.3 Ensembl ENCODE 6.4 +92.2 92233 3.4 HDGF ARNT CREB3L1 SIN3A DMAP1 ZNF2 ZNF766 ZNF143 FOS KLF13 ENSG00000272100 RAB3B CC2D1B GC01P051906 MIR761 NRDC
GH01F051923 0.6 ENCODE 10.9 +66.0 65974 1.7 CTCF JUND MCM3 GLIS1 FOS REST RAD21 RAB3B ENSG00000223390 KTI12 GC01P051906 GC01P051974
GH01F051927 0.4 ENCODE 11.7 +63.6 63561 0.2 FOSL1 RAB3B GC01P051906 GC01P051974
GH01F051989 0.8 ENCODE 0.8 +0.4 362 1.0 KLF1 GLIS2 POLR2A PRDM10 NFE2 ZNF600 KLF8 SP3 MAZ RNF2 RAB3B GC01P051981
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RAB3B on UCSC Golden Path with GeneCards custom track

Promoters for RAB3B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000165250 464 1800 KLF1 INSM2 ZNF316 ZFHX2 GLIS2 POLR2A PRDM10 ZNF600 NFE2 SP3

Genomic Location for RAB3B Gene

Chromosome:
1
Start:
51,907,956 bp from pter
End:
51,990,764 bp from pter
Size:
82,809 bases
Orientation:
Minus strand

Genomic View for RAB3B Gene

Genes around RAB3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB3B Gene

Proteins for RAB3B Gene

  • Protein details for RAB3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20337-RAB3B_HUMAN
    Recommended name:
    Ras-related protein Rab-3B
    Protein Accession:
    P20337
    Secondary Accessions:
    • Q5VUL2
    • Q9BSI1

    Protein attributes for RAB3B Gene

    Size:
    219 amino acids
    Molecular mass:
    24758 Da
    Quaternary structure:
    • Interacts with RIMS1, RIMS2, RPH3A and RPH3AL.

    Three dimensional structures from OCA and Proteopedia for RAB3B Gene

neXtProt entry for RAB3B Gene

Post-translational modifications for RAB3B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB3B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RAB3B Gene

Domains & Families for RAB3B Gene

Gene Families for RAB3B Gene

Protein Domains for RAB3B Gene

Suggested Antigen Peptide Sequences for RAB3B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P20337

UniProtKB/Swiss-Prot:

RAB3B_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB3B: view

Function for RAB3B Gene

Molecular function for RAB3B Gene

GENATLAS Biochemistry:
RAB3B,Ras oncogene superfamily member,involved in calcium regulated exocytosis
UniProtKB/Swiss-Prot Function:
Protein transport. Probably involved in vesicular traffic (By similarity).

Gene Ontology (GO) - Molecular Function for RAB3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IDA 24891604
GO:0005515 protein binding IPI 24891604
GO:0005525 GTP binding IEA --
GO:0019003 GDP binding IDA 22321395
GO:0030742 GTP-dependent protein binding IEA --
genes like me logo Genes that share ontologies with RAB3B: view
genes like me logo Genes that share phenotypes with RAB3B: view

Animal Models for RAB3B Gene

MGI Knock Outs for RAB3B:

Animal Model Products

miRNA for RAB3B Gene

miRTarBase miRNAs that target RAB3B

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RAB3B

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RAB3B Gene

Localization for RAB3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB3B Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB3B gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytosol 4

Gene Ontology (GO) - Cellular Components for RAB3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 20807725
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane IEA --
GO:0008021 synaptic vesicle IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RAB3B: view

Pathways & Interactions for RAB3B Gene

genes like me logo Genes that share pathways with RAB3B: view

Pathways by source for RAB3B Gene

1 KEGG pathway for RAB3B Gene
1 Qiagen pathway for RAB3B Gene

Gene Ontology (GO) - Biological Process for RAB3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0015031 protein transport IEA --
GO:0017157 regulation of exocytosis IEA --
GO:0018125 peptidyl-cysteine methylation IEA --
genes like me logo Genes that share ontologies with RAB3B: view

No data available for SIGNOR curated interactions for RAB3B Gene

Transcripts for RAB3B Gene

mRNA/cDNA for RAB3B Gene

Unigene Clusters for RAB3B Gene

RAB3B, member RAS oncogene family:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RAB3B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB3B Gene

No ASD Table

Relevant External Links for RAB3B Gene

GeneLoc Exon Structure for
RAB3B
ECgene alternative splicing isoforms for
RAB3B

Expression for RAB3B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RAB3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB3B Gene

This gene is overexpressed in Brain - Hypothalamus (x8.7), Pituitary (x7.1), and Brain - Amygdala (x5.3).

Protein differential expression in normal tissues from HIPED for RAB3B Gene

This gene is overexpressed in Brain (40.0), Placenta (6.6), and Bone (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RAB3B Gene



Protein tissue co-expression partners for RAB3B Gene

NURSA nuclear receptor signaling pathways regulating expression of RAB3B Gene:

RAB3B

SOURCE GeneReport for Unigene cluster for RAB3B Gene:

Hs.123072
genes like me logo Genes that share expression patterns with RAB3B: view

No data available for mRNA Expression by UniProt/SwissProt for RAB3B Gene

Orthologs for RAB3B Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB3B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB3B 34 35
  • 99.54 (n)
cow
(Bos Taurus)
Mammalia RAB3B 34 35
  • 92.85 (n)
dog
(Canis familiaris)
Mammalia RAB3B 34 35
  • 91.78 (n)
mouse
(Mus musculus)
Mammalia Rab3b 34 16 35
  • 89.35 (n)
oppossum
(Monodelphis domestica)
Mammalia RAB3B 35
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rab3b 34
  • 88.58 (n)
chicken
(Gallus gallus)
Aves RAB3B 34 35
  • 77.02 (n)
lizard
(Anolis carolinensis)
Reptilia RAB3B 35
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rab3b 34
  • 75.42 (n)
zebrafish
(Danio rerio)
Actinopterygii rab3b 34 35
  • 71.23 (n)
fruit fly
(Drosophila melanogaster)
Insecta Rab3 36 35
  • 76 (a)
worm
(Caenorhabditis elegans)
Secernentea rab-3 36 35
  • 75 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 75 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4921 34
Species where no ortholog for RAB3B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB3B Gene

ENSEMBL:
Gene Tree for RAB3B (if available)
TreeFam:
Gene Tree for RAB3B (if available)

Paralogs for RAB3B Gene

Variants for RAB3B Gene

Sequence variations from dbSNP and Humsavar for RAB3B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1024311 -- 51,991,487(+) ATTTT(G/T)ACACA upstream-variant-2KB
rs1024312 -- 51,991,494(+) CACAA(G/T)CCCGA upstream-variant-2KB
rs1024313 -- 51,992,509(+) CTTGT(A/G)CAAAA upstream-variant-2KB
rs1045633 -- 51,908,191(-) ACTGA(C/T)ACCTC utr-variant-3-prime
rs10465800 -- 51,992,581(+) aattg(C/T)tcctt upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RAB3B Gene

Variant ID Type Subtype PubMed ID
nsv945942 CNV duplication 23825009
nsv843 CNV insertion 18451855
nsv829848 CNV loss 17160897
nsv829837 CNV loss 17160897
nsv546227 CNV gain+loss 21841781
nsv546226 CNV gain+loss 21841781
nsv546211 CNV loss 21841781
nsv546209 CNV gain 21841781
nsv509246 CNV insertion 20534489
nsv475146 CNV novel sequence insertion 20440878
nsv1076427 CNV deletion 25765185
nsv1001512 CNV gain 25217958
esv24521 CNV loss 19812545
esv1693930 CNV insertion 17803354
esv1010825 CNV insertion 20482838
dgv272n54 CNV loss 21841781
dgv271n54 CNV loss 21841781
dgv270n54 CNV loss 21841781
dgv269n54 CNV loss 21841781
dgv268n54 CNV gain+loss 21841781

Variation tolerance for RAB3B Gene

Residual Variation Intolerance Score: 37.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.73; 15.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAB3B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAB3B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB3B Gene

Disorders for RAB3B Gene

Relevant External Links for RAB3B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAB3B

No disorders were found for RAB3B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB3B Gene

Publications for RAB3B Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion. (PMID: 2501306) Zahraoui A. … Tavitian A. (J. Biol. Chem. 1989) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Cargo-selective apical exocytosis in epithelial cells is conducted by Myo5B, Slp4a, Vamp7, and Syntaxin 3. (PMID: 26553929) Vogel G.F. … Huber L.A. (J. Cell Biol. 2015) 3 64

Products for RAB3B Gene

Sources for RAB3B Gene

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