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Aliases for RAB3B Gene

Aliases for RAB3B Gene

  • RAB3B, Member RAS Oncogene Family 2 3 5

External Ids for RAB3B Gene

Previous GeneCards Identifiers for RAB3B Gene

  • GC01M051273
  • GC01M051732
  • GC01M051754
  • GC01M052096
  • GC01M052373
  • GC01M050490

Summaries for RAB3B Gene

GeneCards Summary for RAB3B Gene

RAB3B (RAB3B, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Tight junction and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB37.

UniProtKB/Swiss-Prot for RAB3B Gene

  • Protein transport. Probably involved in vesicular traffic (By similarity).

Gene Wiki entry for RAB3B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB3B Gene

Genomics for RAB3B Gene

Regulatory Elements for RAB3B Gene

Enhancers for RAB3B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RAB3B on UCSC Golden Path with GeneCards custom track

Promoters for RAB3B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RAB3B on UCSC Golden Path with GeneCards custom track

Genomic Location for RAB3B Gene

51,907,956 bp from pter
51,990,764 bp from pter
82,809 bases
Minus strand

Genomic View for RAB3B Gene

Genes around RAB3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB3B Gene

Proteins for RAB3B Gene

  • Protein details for RAB3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras-related protein Rab-3B
    Protein Accession:
    Secondary Accessions:
    • Q5VUL2
    • Q9BSI1

    Protein attributes for RAB3B Gene

    219 amino acids
    Molecular mass:
    24758 Da
    Quaternary structure:
    • Interacts with RIMS1, RIMS2, RPH3A and RPH3AL.

    Three dimensional structures from OCA and Proteopedia for RAB3B Gene

neXtProt entry for RAB3B Gene

Proteomics data for RAB3B Gene at MOPED

Post-translational modifications for RAB3B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB3B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RAB3B Gene

Domains & Families for RAB3B Gene

Gene Families for RAB3B Gene

Suggested Antigen Peptide Sequences for RAB3B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Rab family.
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB3B: view

Function for RAB3B Gene

Molecular function for RAB3B Gene

GENATLAS Biochemistry:
RAB3B,Ras oncogene superfamily member,involved in calcium regulated exocytosis
UniProtKB/Swiss-Prot Function:
Protein transport. Probably involved in vesicular traffic (By similarity).
genes like me logo Genes that share phenotypes with RAB3B: view

Animal Models for RAB3B Gene

MGI Knock Outs for RAB3B:

Animal Model Products

miRNA for RAB3B Gene

miRTarBase miRNAs that target RAB3B

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RAB3B Gene

Localization for RAB3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB3B Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

Jensen Localization Image for RAB3B Gene COMPARTMENTS Subcellular localization image for RAB3B gene
Compartment Confidence
extracellular 5
cytosol 4
plasma membrane 4

Gene Ontology (GO) - Cellular Components for RAB3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008021 synaptic vesicle IEA --
GO:0048471 perinuclear region of cytoplasm IDA 19717423
genes like me logo Genes that share ontologies with RAB3B: view

Pathways & Interactions for RAB3B Gene

genes like me logo Genes that share pathways with RAB3B: view

Pathways by source for RAB3B Gene

1 KEGG pathway for RAB3B Gene
1 Qiagen pathway for RAB3B Gene

Gene Ontology (GO) - Biological Process for RAB3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006913 nucleocytoplasmic transport IEA --
GO:0018125 peptidyl-cysteine methylation IEA --
GO:0019882 antigen processing and presentation IMP 19717423
genes like me logo Genes that share ontologies with RAB3B: view

No data available for SIGNOR curated interactions for RAB3B Gene

Drugs & Compounds for RAB3B Gene

No Compound Related Data Available

Transcripts for RAB3B Gene

mRNA/cDNA for RAB3B Gene

Unigene Clusters for RAB3B Gene

RAB3B, member RAS oncogene family:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAB3B Gene

No ASD Table

Relevant External Links for RAB3B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RAB3B Gene

mRNA expression in normal human tissues for RAB3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB3B Gene

This gene is overexpressed in Brain - Hypothalamus (x8.7), Pituitary (x7.1), and Brain - Amygdala (x5.3).

Protein differential expression in normal tissues from HIPED for RAB3B Gene

This gene is overexpressed in Brain (40.0), Placenta (6.6), and Bone (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB3B Gene

SOURCE GeneReport for Unigene cluster for RAB3B Gene Hs.123072

genes like me logo Genes that share expression patterns with RAB3B: view

Protein tissue co-expression partners for RAB3B Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for RAB3B Gene

Orthologs for RAB3B Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB3B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RAB3B 35
  • 92.85 (n)
  • 97.72 (a)
RAB3B 36
  • 98 (a)
(Canis familiaris)
Mammalia RAB3B 35
  • 91.78 (n)
  • 97.26 (a)
RAB3B 36
  • 88 (a)
(Mus musculus)
Mammalia Rab3b 35
  • 89.35 (n)
  • 97.26 (a)
Rab3b 16
Rab3b 36
  • 97 (a)
(Pan troglodytes)
Mammalia RAB3B 35
  • 99.54 (n)
  • 99.54 (a)
RAB3B 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rab3b 35
  • 88.58 (n)
  • 95.89 (a)
(Monodelphis domestica)
Mammalia RAB3B 36
  • 89 (a)
(Gallus gallus)
Aves RAB3B 35
  • 77.02 (n)
  • 83.11 (a)
RAB3B 36
  • 81 (a)
(Anolis carolinensis)
Reptilia RAB3B 36
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rab3b 35
  • 75.42 (n)
  • 82.95 (a)
(Danio rerio)
Actinopterygii rab3b 35
  • 71.23 (n)
  • 81.13 (a)
rab3b 36
  • 80 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rab3 37
  • 76 (a)
Rab3 36
  • 76 (a)
(Caenorhabditis elegans)
Secernentea rab-3 37
  • 75 (a)
rab-3 36
  • 68 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4921 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 75 (a)
Species with no ortholog for RAB3B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB3B Gene

Gene Tree for RAB3B (if available)
Gene Tree for RAB3B (if available)

Paralogs for RAB3B Gene

genes like me logo Genes that share paralogs with RAB3B: view

Variants for RAB3B Gene

Sequence variations from dbSNP and Humsavar for RAB3B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs11212 -- 51,908,115(+) ACTGT(A/G)TATAT utr-variant-3-prime
rs12730 -- 51,908,222(-) CATGC(G/T)TTTTT utr-variant-3-prime
rs970739 -- 51,969,553(+) AGTAT(G/T)AGCAA intron-variant
rs1024311 -- 51,991,487(+) ATTTT(G/T)ACACA upstream-variant-2KB
rs1024312 -- 51,991,494(+) CACAA(G/T)CCCGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RAB3B Gene

Variant ID Type Subtype PubMed ID
nsv829837 CNV Loss 17160897
nsv843 CNV Insertion 18451855
nsv829848 CNV Loss 17160897
nsv509246 CNV Insertion 20534489
esv1010825 CNV Insertion 20482838
esv1693930 CNV Insertion 17803354
esv24521 CNV Loss 19812545

Variation tolerance for RAB3B Gene

Residual Variation Intolerance Score: 37.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.73; 15.54% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RAB3B Gene

Disorders for RAB3B Gene

Relevant External Links for RAB3B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RAB3B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB3B Gene

Publications for RAB3B Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Rab18 and a Rab18 GEF complex are required for normal ER structure. (PMID: 24891604) Gerondopoulos A. … Barr F.A. (J. Cell Biol. 2014) 3
  4. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3
  5. Identification and characterization of multiple novel Rab-myosin Va interactions. (PMID: 24006491) Lindsay A.J. … Goud B. (Mol. Biol. Cell 2013) 3

Products for RAB3B Gene

Sources for RAB3B Gene