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Aliases & Descriptions for RAB3B
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| OTTHUMP00000010299 2 |
| | | Descriptions |
|---|
| Brain antigen RAB3B 2 | | RAB3B, member RAS oncogene family 2 |
|
| | Search outside databases for aliases for RAB3B genePrevious GC identifers: GC01M051978 GC01M051273 GC01M051732 GC01M051754 |
Summaries for RAB3B(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: RAB3B_HUMAN, P20337Function: Protein transport. Probably involved in vesicular traffic (By similarity)Gene Wiki entry for RAB3B |
Genomic Location for RAB3B
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the RAB3B gene 
Entrez Gene cytogenetic band: 1p32-p31 Ensembl cytogenetic band: 1p32.3 HGNC cytogenetic band: 1p32-p31RAB3B Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M052096:
(about GC identifiers)
Start:
|
52,157,420 bp from pter |
End:
|
52,228,936 bp from pter |
Size:
|
71,517 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000001.9 NT_032977.8
| Proteins for RAB3B
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: RAB3B_HUMAN, P20337 (See
protein sequence)Recommended Name: Ras-related protein Rab-3B Size: 219 amino acids; 24758 Da
Subunit: Binds RIMS1 and RIMS2 (By similarity)
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
PDB structures from and Proteopedia :3DZ8 (3D)
 
Secondary accessions: Q5VUL2 Q9BSI1Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_002858.2
ENSEMBL proteins: ENSP00000360718
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
IEA | -- | | GO:0008021 | synaptic vesicle |
IEA | -- | About this table
Antibodies for RAB3B: Assays for RAB3B: | Protein
Domains/ Families for RAB3B(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P20337
ProtoNet protein and cluster: P20337 1 Blocks protein family: IPB001806 Transforming protein P21 RAS signature
UniProtKB/Swiss-Prot: RAB3B_HUMAN, P20337Similarity: Belongs to the small GTPase superfamily. Rab family | Gene Function for RAB3B
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002867
Applied Biosystems Silencer® siRNAs for RAB3B
Sigma-Aldrich siRNA for RAB3B  Sigma-Aldrich shRNA for RAB3B  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002867                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_002867                                  untagged cDNA clone in CMV expression vector: NM_002867 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_002867
UniProtKB/Swiss-Prot: RAB3B_HUMAN, P20337Function: Protein transport. Probably involved in vesicular traffic (By similarity)Genatlas biochemistry entry for RAB3B:RAB3B,Ras oncogene superfamily member,involved in calcium regulated exocytosis7 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Rab3b):
4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for RAB3B
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 1 Sigma-Aldrich "Your Favorite Gene" Pathway for RAB3B (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for RAB3B 
5 Interacting proteins for RAB3B (ENSP000003607183) via UniProtKB, MINT, and/or STRINGAbout this table
4 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007264 | small GTPase mediated signal transduction |
IEA | -- | | GO:0015031 | protein transport |
IEA | -- | | GO:0017157 | regulation of exocytosis |
IEA | -- | | GO:0018125 | peptidyl-cysteine methylation |
IEA | -- | About this table
|
Drugs & Compounds for RAB3B(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|  |
Enzo Life Sciences drugs & compounds for RAB3B |
Browse Tocris compounds for RAB3B
|
Transcripts for RAB3B(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002867
Sigma-Aldrich siRNA for RAB3B  Sigma-Aldrich shRNA for RAB3B  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_002867 REFSEQ mRNAs for RAB3B gene: NM_002867.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_002867               OriGene GFP tagged cDNA clone in CMV expression vector: NM_002867                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_002867                                  untagged cDNA clone in CMV expression vector: NM_002867  Additional cDNA sequence: AF498932.1 AK002107.1 AK291653.1 BC005035.1 M28214.1 7 DOTS entries: DT.311944 DT.204371 DT.95321936 DT.100020015 DT.100791955 DT.121328107 DT.454490 24/57 AceView cDNA sequences (see all 57
):CK826166 BC005035 BP349017 BM799574 AI962239 AF498932 BM311381 BQ651429 BF980502 BQ777831 AU119030 BQ477352 BX091219 NM_002867 BE466153 BX280189 BP364430 AU124033 BG331007 CF593462 CB107139 BQ422619 BP349085 BQ477770
highest scoring ESTs for RAB3B:M28214 AU099235 AU119030 AU124033 BC005035 BF183279 BG331007 BQ477770 BQ777831 CB107139 Unigene Cluster for RAB3B: RAB3B, member RAS oncogene family Hs.123072 [show with all ESTs]Unigene Representative Sequence: AK002107
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000371655
|
Expression for RAB3B
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| RAB3B expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for RAB3B
1 / 2 / 3 8 probe-sets matching RAB3B gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TGTTGTGAGT
SOURCE GeneReport for Unigene cluster: Hs.123072
Expression variation in blood from EXPOLDB for RAB3B |
Orthologs for RAB3B
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for RAB3B gene from 5/10 species (see all 10
)
About this table Species with no ortholog for RAB3B
ENSEMBL Gene Tree for RAB3B | Paralogs for RAB3B(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for RAB3B gene
- RAB3A2 RAB122 RAB3D2 RAB3C2
|
SNPs/Variants for RAB3B(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for RAB3B (up to first 250kb)
|
Disorders & Mutations for RAB3B
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 179510
|
Medical News for RAB3B(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for RAB3B (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/14 PubMed articles for RAB3B gene (see all 14
):- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)3, 4 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion. (PubMed id 2501306)3, 4 Zahraoui A.... Tavitian A. (1989)
- High-throughput mapping of a dynamic signaling network in mammalian cells. (PubMed id 15761153)3 Barrios-Rodiles M....Wrana J.L. (2005)
- Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells. (PubMed id 15159548)3 Matsumoto M....Seino S. (2004)
- Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2. (PubMed id 12578829)3 Fukuda M. (2003)
- Distinct roles of Rab3B and Rab13 in the polarized transport of apical, basolateral, and tight junctional membrane proteins to the plasma membrane. (PubMed id 12901864)3 Yamamoto Y....Sasaki T. (2003)
- Direct interaction between Rab3b and the polymeric immunoglobulin receptor controls ligand-stimulated transcytosis in epithelial cells. (PubMed id 11832247)3 van IJzendoorn S.C....Mostov K.E. (2002)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- Rab3B in human platelet is membrane bound and interacts with Ca(2+)/calmodulin. (PubMed id 11741295)3 Sidhu R.S. and Bhullar R.P. (2001)
|
Search for RAB3B
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing RAB3B
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing RAB3B
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RAB3B(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for RAB3B(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for RAB3B:

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Incremental update: 13 Oct 2009
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