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RAB3B Gene

protein-coding   GIFtS: 60

GC01M052096
RAB3B, member RAS oncogene family
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
OTTHUMP00000010299 2
Descriptions
Brain antigen RAB3B 2
RAB3B, member RAS oncogene family 2
External Ids
HGNC: 97781
Entrez Gene: 58652
UniProtKB: P203373
Ensembl: ENSG000001692137
Search outside databases for aliases for RAB3B gene

Previous GC identifers: GC01M051978 GC01M051273 GC01M051732 GC01M051754

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: RAB3B_HUMAN, P20337
Function: Protein transport. Probably involved in vesicular traffic (By similarity)

Gene Wiki entry for RAB3B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the RAB3B gene  

Entrez Gene cytogenetic band: 1p32-p31   Ensembl cytogenetic band:  1p32.3   HGNC cytogenetic band: 1p32-p31

RAB3B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M052096:     (about GC identifiers)

Start:
52,157,420 bp from pter
End:
52,228,936 bp from pter
Size:
71,517 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000001.9  NT_032977.8  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: RAB3B_HUMAN, P20337 (See protein sequence)
Recommended Name: Ras-related protein Rab-3B  
Size: 219 amino acids; 24758 Da
Subunit: Binds RIMS1 and RIMS2 (By similarity)
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
PDB structures from and Proteopedia :
3DZ8 (3D)    
Secondary accessions: Q5VUL2 Q9BSI1

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_002858.2  

    ENSEMBL proteins: 
    ENSP00000360718 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Sigma-Aldrich AQUA Peptides for RAB3B  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (RAB3B, Rab3A + Rab3B + Rab3C + Rab3D)
    Human Recombinant Proteins from Abnova (RAB3B)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886 plasma membrane IEA--
    GO:0008021 synaptic vesicle IEA--
    About this table

    Antibodies for RAB3B: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for RAB3B
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (RAB3B, Rab3A + Rab3B + Rab3C + Rab3D), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (RAB3B)
    Novus Biologicals Antibody for RAB3B

    Assays for RAB3B: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5 InterPro domains/families:
     IPR015596 Rab3
     IPR001806 Ras_GTPase
     IPR005225 Small_GTP_bd
     IPR003579 GTPase_Rab
     IPR013753 Ras


       GeneDecks  RAB3B for the domains selected above  
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    Graphical View of Domain Structure for InterPro Entry P20337

    ProtoNet protein and cluster: P20337

    1 Blocks protein family: IPB001806 Transforming protein P21 RAS signature

    UniProtKB/Swiss-Prot: RAB3B_HUMAN, P20337
    Similarity: Belongs to the small GTPase superfamily. Rab family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (RAB3B)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (RAB3B)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002867

                  Applied Biosystems Silencer® siRNAs for RAB3B

                  Sigma-Aldrich siRNA for RAB3B  
                         Sigma-Aldrich shRNA for RAB3B  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for RAB3B
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_002867
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_002867
                                     untagged cDNA clone in CMV expression vector: NM_002867 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_002867

    UniProtKB/Swiss-Prot: RAB3B_HUMAN, P20337
    Function: Protein transport. Probably involved in vesicular traffic (By similarity)

    Genatlas biochemistry entry for RAB3B:
    RAB3B,Ras oncogene superfamily member,involved in calcium regulated exocytosis

    7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rab3b):

    behavior/neurologicalgrowth/sizehomeostasis/metabolismlethality-prenatal/perinatalnervous system
    normalrespiratory system

    4 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0003924 GTPase activity TAS2501306
    GO:0005515 protein binding IEA--
    GO:0005525 GTP binding IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    1 Sigma-Aldrich "Your Favorite Gene" Pathway for  RAB3B  (Your Favorite Gene powered by Ingenuity) 
     TR/RXR Activation

       GeneDecks  RAB3B for the pathways selected above  
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    1 Kegg Pathway  (Kegg details for RAB3B):
     hsa04530 Tight junction

       GeneDecks  RAB3B for the pathways selected above  
    About GeneDecksing
     Gene Network CentralTM Interacting Genes and Proteins Network for  RAB3B 


    5 Interacting proteins for RAB3B (ENSP000003607183) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPH3ALENSP000003192103STRING (score=.986)
    CALM3ENSP000002912953STRING (score=.942)
    PIGRENSP000003488883STRING (score=.93)
    RAB3GAP1ENSP000002641583STRING (score=.75)
    --ENSP000003538363STRING (score=.958)
    About this table

    4 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007264 small GTPase mediated signal transduction IEA--
    GO:0015031 protein transport IEA--
    GO:0017157 regulation of exocytosis IEA--
    GO:0018125 peptidyl-cysteine methylation IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Enzo Life Sciences drugs & compounds for RAB3B
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for RAB3B

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (RAB3B)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (RAB3B)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002867

                  Sigma-Aldrich siRNA for RAB3B  
                         Sigma-Aldrich shRNA for RAB3B  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_002867  

    REFSEQ mRNAs for RAB3B gene: 

    NM_002867.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_002867  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_002867
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_002867
                                     untagged cDNA clone in CMV expression vector: NM_002867 

    Additional cDNA sequence: 

    AF498932.1 AK002107.1 AK291653.1 BC005035.1 M28214.1 

    7 DOTS entries:

    DT.311944  DT.204371  DT.95321936  DT.100020015  DT.100791955  DT.121328107  DT.454490 

    24/57 AceView cDNA sequences (see all 57 ):

    CK826166 BC005035 BP349017 BM799574 AI962239 AF498932 BM311381 BQ651429 
    BF980502 BQ777831 AU119030 BQ477352 BX091219 NM_002867 BE466153 BX280189 
    BP364430 AU124033 BG331007 CF593462 CB107139 BQ422619 BP349085 BQ477770 

    highest scoring ESTs for RAB3B:

    M28214 AU099235 AU119030 AU124033 BC005035 BF183279 BG331007 BQ477770 BQ777831 CB107139 

    Unigene Cluster for RAB3B:

    RAB3B, member RAS oncogene family
    Hs.123072  [show with all ESTs]
    Unigene Representative Sequence: AK002107


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000371655  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    RAB3B expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for RAB3B

    1 / 2 / 3

    8 probe-sets matching RAB3B gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    624_at2, 3 U95-A 2 1.00 0.97 0.90 0.60 M28214 1.00 1.00 1.00 1
    88357_at*2, 3 U95-E 1 0.94 1.00 0.69 1.44 R76472 0.40 1.00 0.76 1

    205925_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_002867 0.60 1.00 0.82 1

    205924_at2, 3 U133-A 1 1.00 1.00 -- -- BC005035 0.80 1.00 0.91 1

    239202_at*2, 3 U133-B 1 1.00 1.00 -- -- BE552383 0.40 1.00 0.76 1

    205925_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    205924_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    239202_at*2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  RAB3B for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TGTTGTGAGT

    SOURCE GeneReport for Unigene cluster: Hs.123072

    Expression variation in blood from EXPOLDB for RAB3B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for RAB3B gene from 5/10 species (see all 10 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    RAB3B1   -- RAB3B, member RAS oncogene family 91.78(n)
    97.26(a)
    608161  XM_844537.1  XP_849630.1 
    chimpanzee
    (Pan troglodytes)
    RAB3B1   -- RAB3B, member RAS oncogene family 99.54(n)
    99.54(a)
    736412  XM_001143400.1  XP_001143400.1 
    cow
    (Bos taurus)
    RAB3B1   -- RAB3B, member RAS oncogene family 92.85(n)
    97.72(a)
    282030  NM_174447.3  NP_776872.1 
    rat
    (Rattus norvegicus)
    Rab3b1   -- RAB3B, member RAS oncogene family 88.58(n)
    95.89(a)
    81755  NM_031091.2  NP_112353.1 
    mouse
    (Mus musculus)
    Rab3b1, 5 45
    RAB3B, member RAS oncogene family1, 5 89.35(n)1
    97.26(a)1
    699081  NM_023537.51  NP_076026.11 
     AB2325885  AF3075145  (see all 13)
    About this table        Species with no ortholog for RAB3B

    ENSEMBL Gene Tree for RAB3B
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for RAB3B gene
    RAB3A2  RAB122  RAB3D2  RAB3C2  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/342 NCBI SNPs in RAB3B are shown (see all 342 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 128)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 1 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs74161501,2
    A,C,F,H52230404(+) CCCAAG/TTTCCA 1 -- ng314Minor allele frequency- T:0.04EU EA WA 418
    rs10243111,2
    C,F,H52229747(+) ATTTTG/TACACA 1 -- ng318Minor allele frequency- T:0.03MN EU EA WA NA 742
    rs10243131,2
    A,F,H52230769(+) CTTGTG/ACAAAA 1 -- ng315Minor allele frequency- A:0.03MN EU EA WA 600
    rs104658001,2
    F,H52230841(+) aattgC/Ttcctt 1 -- ng314Minor allele frequency- T:0.03EU EA WA 394
    rs120303881,2
    F,H52229425(+) TCCAGC/TATCAT 1 -- ng314Minor allele frequency- T:0.05EU EA WA 420
    --
    rs17735691,2
    A,F52230855(+) CATTAC/AAGATT 1 -- ng311Minor allele frequency- A:0.06MN 184
    rs120232101,2
    F,H52229374(+) CCTTAA/GCATAT 1 -- ng31 tfbs34Minor allele frequency- G:0.05EU EA WA 420
    rs171068861,2
    C,F52171609(+) TTCTCA/GGTGGG 1 T/T syn1 ese34Minor allele frequency- G:0.07NA 218
    rs28099481,2
    A,C,F,H,O52196682(+) AAGCCG/AGTAAG 1 -- int17Minor allele frequency- A:0.12EU EA WA NA 558
    rs28099491,2
    A,C,F,H,O52198541(+) GAATAC/TGACAA 1 -- int111Minor allele frequency- T:0.13EU EA WA NA 976
    About this table

    HapMap Linkage Disequilibrium images for RAB3B (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 179510

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/14 PubMed articles for RAB3B gene (see all 14 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 5865 HGNC: 9778 AceView: RAB3B Ensembl:ENSG00000169213 euGenes: HUgn5865
    ECgene: RAB3B H-InvDB: RAB3B
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for RAB3B Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for RAB3B:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant Proteins
    (RAB3B, Rab3A + Rab3B + Rab3C + Rab3D)
     Antibodies (RAB3B, Rab3A + Rab3B + Rab3C + Rab3D)
     Search OriGene for RAB3B
     Search Tocris compounds for RAB3B




     Drugs for RAB3B
     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for RAB3B

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