RAB3B Gene
protein-coding GIFtS : 55
GCID: GC01 M052373
RAB3B, member RAS oncogene family
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Aliasesfor RAB3B gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases RAB3B, Member RAS Oncogene Family 1 2 Brain Antigen RAB3B2 Ras-Related Protein Rab-3B2
Export aliases for RAB3B gene to outside databases Previous GC identifers: GC01M051978 GC01M051273 GC01M051732 GC01M051754 GC01M052096 GC01M050490
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Summariesfor RAB3B gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: RAB3B_HUMAN, P20337 Function : Protein transport. Probably involved in vesicular traffic (By similarity)Gene Wiki entry for RAB3B
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Genomic Viewsfor RAB3B gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000001.10 NC_018912.1 NT_032977.9 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the RAB3B gene promoter: Tal-1 Sp1 CUTL1 STAT5A Cdc5 STAT3 ZID Pax-4a Other transcription factors Search SABiosciences Chromatin IP Primers for RAB3B Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB3B
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 1p32-p31 Ensembl cytogenetic band: 1p32.3 HGNC cytogenetic band: 1p32-p31 RAB3B Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01M052373: view genomic region
(about GC identifiers )
Start:
52,373,628 bp from pter
End:
52,456,436 bp from pter
Size:
82,809 bases
Orientation:
minus strand
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Proteinsfor RAB3B gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: RAB3B_HUMAN, P20337 (See
protein sequence )Recommended Name: Ras-related protein Rab-3B Size : 219 amino acids; 24758 Da
Subunit : Interacts with RIMS1, RIMS2, RPH3A and RPH3AL (By similarity)
Subcellular location : Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
1 PDB 3D structure from and Proteopedia for RAB3B :3DZ8 (3D)
 
Secondary accessions : Q5VUL2 Q9BSI1Explore the universe of human proteins at neXtProt for RAB3B: NX_P20337 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P20337 RAB3B Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_002858.2 ENSEMBL proteins: ENSP00000360718 ENSP00000439315 Human Recombinant Protein Products: Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view) : About this table
RAB3B for ontologies About GeneDecksing RAB3B Antibody Products: Assay Products for RAB3B:
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Protein
Domains / Familiesfor RAB3B gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
RAB3B for domains About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P20337 ProtoNet protein and cluster: P20337
1 Blocks protein family : IPB001806 Transforming protein P21 RAS signature UniProtKB/Swiss-Prot: RAB3B_HUMAN, P20337 Similarity : Belongs to the small GTPase superfamily. Rab family
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Functionfor RAB3B gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: RAB3B_HUMAN, P20337 Function : Protein transport. Probably involved in vesicular traffic (By similarity)
Genatlas biochemistry entry for RAB3B : RAB3B,Ras oncogene superfamily member,involved in calcium regulated exocytosis Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for RAB3B (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for RAB3BOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: RAB3B (NM_002867 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RAB3B Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RAB3B
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB3B
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view) : About this table
RAB3B for ontologies About GeneDecksing Animal Models: Mouse knock-out Rab3b tm1Sud for RAB3B 7 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Rab3b) :
RAB3B for phenotypes About GeneDecksing
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Pathways & Interactionsfor RAB3B gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways   About this table See pathways by source Super-pathway contained gene-specific pathways 1 Tight junction 2 Sertoli-Sertoli Cell Junction Dynamics
Pathway sources See GeneCards unified pathways Show all pathways 1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RAB3B 1
Kegg Pathway (Kegg details for RAB3B) :
RAB3B for pathways About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAB3B STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/56 Interacting proteins for RAB3B (P20337 3 ENSP00000360718 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 56 )About this table Gene Ontology (GO): 5 biological process terms (GO ID links to tree view) : About this table
RAB3B for ontologies About GeneDecksing
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Drugs & Compoundsfor RAB3B gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for RAB3B Search CenterWatch for drugs/clinical trials and news about RAB3B
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Transcriptsfor RAB3B gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for RAB3B gene: NM_002867.3 Unigene Cluster for RAB3B:
RAB3B, member RAS oncogene family Hs.123072 [show with all ESTs ] Unigene Representative Sequence: NM_002867 2 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000371655 (uc001cth.3 ) ENST00000537650 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for RAB3B (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for RAB3BOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: RAB3B (NM_002867 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RAB3B Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RAB3B
Additional cDNA sequence: AB074163.1 AF498932.1 AK002107.1 AK092167.1 AK291653.1 BC005035.1 M28214.1
7 DOTS entries : DT.311944 DT.100020015
DT.204371 DT.95321936 DT.100791955 DT.121328107 DT.454490 24/57 AceView cDNA sequences (see all 57 ):
NM_002867 BP364430 BM311381 AI962239 BC005035 BQ777831 BF980502 AF498932 BQ477352 BQ651429 BP349017 BX280189 BE466153 AU119030 BM799574 AU124033 CK826166 BX091219 AU099235 BM471500 BG331007 BQ422619 M28214 BP363775 GeneLoc Exon Structure
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Expression for RAB3B gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section RAB3B expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TGTTGTGAGT
About this image RAB3B expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See RAB3B Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for RAB3B SOURCE GeneReport for Unigene cluster: Hs.123072 SABiosciences Custom PCR Arrays for RAB3B Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for RAB3BBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat RAB3B QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat RAB3B QIAGEN QuantiFast Probe-based Assays in human , mouse , rat RAB3B In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB3B
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Orthologsfor RAB3B gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for RAB3B gene from 7/24 species (see all 24 ) About this table
ENSEMBL Gene Tree for RAB3B (if available)TreeFam Gene Tree for RAB3B (if available)
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Paralogsfor RAB3B gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for RAB3B gene RAB23 2 RAB27A 2 RAB3A 2 RAB27B 2 RAB3D 2 RAB3C 2 18/83 SIMAP similar genes for RAB3B using alignment to 1 protein entry: RAB3B_HUMAN (see all similar genes ):RAB3A RAB3C RAB3D RAB8B RAB8A RAB13 RAB10 RAB15 RAB11A RAB12 RAB30 RAB11B RAB35 RAB26 RAB27B RAB27A DKFZp686J07132 RAB1C
RAB3B for paralogs About GeneDecksing
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Genomic Variantsfor RAB3B gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 1 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for RAB3B (52373628 - 52456436 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 13 variations for RAB3B 12 CNVs : 84237 84243 74480 84238 84241 74481 84235 4224 84242 4223 84236 74482 1 Indel : 68606
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing RAB3B
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Disorders
/ Diseasesfor RAB3B gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
RAB3B for disorders About GeneDecksing
OMIM gene information: 179510
OMIM disorders : --5 diseases for RAB3B : About MalaCards pituitary adenoma adenoma pharyngitis neuronitis alcoholism Export disorders for RAB3B gene to outside databases
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Publicationsfor RAB3B gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for RAB3B gene, integrated from 9 sources (see all 27 ): (articles sorted by number of sources associating them with RAB3B) Utopia : connect your pdf to the dynamic world of online information
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414) 1 , 2 Gregory S.G.... Bentley D.R. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion. (PubMed id 2501306) 1 , 2 Zahraoui A.... Tavitian A. (1989) Crystal structure of inactive form of Rab3B. (PubMed id 22321395) 1 Zhang W....Qi C. (2012) Integrative analysis of the ubiquitin proteome isolat ed using Tandem Ubiquitin Binding Entities (TUBEs). (PubMed id 22178446) 1 Lopitz-Otsoa F....Rodriguez M.S. (2011) Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983) 1 Kim W....Gygi S.P. (2011) System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692) 2 Rigbolt K.T....Blagoev B. (2011) Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048) 1 Danielsen J.M....Nielsen M.L. (2011) In vitro expression of NGN3 identifies RAB3B as the p redominant Ras-associated GTP-binding protein 3 family member in human islets. (PubMed id 20807725) 1 Piper Hanley K....Hanley N.A. (2010) Rab3B immunoexpression in human pituitary adenomas. (PubMed id 19384079) 1 Rotondo F....Bell D.C. (2009)
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External Searches for RAB3B gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing RAB3B gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing RAB3B gene
(According to HUGE )
About This Section --
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Specialized Databases showing RAB3B gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for RAB3B gene: Search GeneIP for patents involving RAB3B GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor RAB3B gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for RAB3B OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for RAB3B OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for RAB3B OriGene Protein Over-expression Lysate for RAB3B Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for RAB3B OriGene 3'-UTR Clone for RAB3B OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for RAB3B OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for RAB3B Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RAB3B QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing RAB3B QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB3B QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat RAB3B QIAGEN QuantiFast Probe-based Assays in human , mouse , rat RAB3B QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat RAB3B
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