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Aliases & Descriptions for RAB3A
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| | | Descriptions |
|---|
| RAB3A, member RAS oncogene family 2 | | RAS-associated protein RAB3A 2 |
|
| | Search outside databases for aliases for RAB3A genePrevious GC identifers: GC19M018801 GC19M018699 GC19M018152 |
Summaries for RAB3A(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: RAB3A_HUMAN, P20336Function: Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminalGene Wiki entry for RAB3A |
Genomic Location for RAB3A
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the RAB3A gene 
Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.11 HGNC cytogenetic band: 19p13.2RAB3A Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M018168:
(about GC identifiers)
Start:
|
18,168,611 bp from pter |
End:
|
18,175,839 bp from pter |
Size:
|
7,229 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000019.8 NT_011295.10
| Proteins for RAB3A
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: RAB3A_HUMAN, P20336 (See
protein sequence)Recommended Name: Ras-related protein Rab-3A Size: 220 amino acids; 24984 Da
Subunit: Heterodimer with RIMS2. Part of a ternary complex involving PCLO and EPAC2. Interacts with RPH3A. Interacts with the exocyst complex through SEC15. Binds SYTL4, RIMS1 and RIMS2. Interacts with RAB3IP. Interacts with SGSM1 and SGSM3 (By similarity)
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
Secondary accessions: Q9NYE1Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_002857.1
ENSEMBL proteins: ENSP00000222256
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for RAB3A: Assays for RAB3A: | Protein
Domains/ Families for RAB3A(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P20336
ProtoNet protein and cluster: P20336 1 Blocks protein family: IPB001806 Transforming protein P21 RAS signature
UniProtKB/Swiss-Prot: RAB3A_HUMAN, P20336Similarity: Belongs to the small GTPase superfamily. Rab family | Gene Function for RAB3A
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002866
Applied Biosystems Silencer® siRNAs for RAB3A
Sigma-Aldrich siRNA and siRNA Panels for RAB3A  Sigma-Aldrich shRNA for RAB3A  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002866                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_002866                                  untagged cDNA clone in CMV expression vector: NM_002866 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_002866
UniProtKB/Swiss-Prot: RAB3A_HUMAN, P20336Function: Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminalGenatlas biochemistry entry for RAB3A:RAB3A,Ras oncogene superfamily member,expressed synaptic vesicles, involved in calcium regulated exocytosis,expressed in parathyroid chief cells7 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Rab3a):
4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for RAB3A
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for RAB3A 
5/45 Interacting proteins for RAB3A (ENSP000002222563) via UniProtKB, MINT, and/or STRING (see all 45
)About this table
5/14 Gene Ontology (GO) biological process terms (links to tree view) (see all 14
): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003016 | respiratory system process |
IEA | -- | | GO:0007005 | mitochondrion organization |
IEA | -- | | GO:0007264 | small GTPase mediated signal transduction |
IEA | -- | | GO:0007274 | neuromuscular synaptic transmission |
IEA | -- | | GO:0007409 | axonogenesis |
IEA | -- | About this table
|
Drugs & Compounds for RAB3A(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|  |
Enzo Life Sciences drugs & compounds for RAB3A |
Browse Tocris compounds for RAB3A 4 Novoseek chemical compound relationships for RAB3A gene
About this table
|
Transcripts for RAB3A(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002866
Sigma-Aldrich siRNA and siRNA Panels for RAB3A  Sigma-Aldrich shRNA for RAB3A  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_002866 REFSEQ mRNAs for RAB3A gene: NM_002866.4
Applied Biosystems TaqMan ® Gene Expression Assays: NM_002866               OriGene GFP tagged cDNA clone in CMV expression vector: NM_002866                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_002866                                  untagged cDNA clone in CMV expression vector: NM_002866  Additional cDNA sequence: AF254795.1 AF498931.1 AK289559.1 AK293467.1 BC011782.2 M28210.1 5 DOTS entries: DT.444206 DT.100653326 DT.100668937 DT.40110695 DT.95301547 24/124 AceView cDNA sequences (see all 124
):AW205498 CA309409 AA364643 BX442130 CD615936 BM926739 BC011782 BI917111 BQ898770 BU739142 BX419052 AL534649 AW163583 AW205866 BM673547 AW160374 BP360364 NM_002866 BM921884 BI820799 BU944659 BI914074 AL517560 AF498931
highest scoring ESTs for RAB3A:M28210 AF254795 AI879002 AW961221 BC011782 BE265314 BE791798 BE792476 BG395376 BG819310 Unigene Cluster for RAB3A: RAB3A, member RAS oncogene family Hs.27744 [show with all ESTs]Unigene Representative Sequence: NM_002866
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for RAB3A
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | |
| SP1: | |   | |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for RAB3A
1 Ensembl transcript including schematic representation: ENST00000222256
|
Expression for RAB3A
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| RAB3A expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for RAB3A
1 / 2 / 3 4 probe-sets matching RAB3A gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: ACAACACTAC
SOURCE GeneReport for Unigene cluster: Hs.27744
Expression variation in blood from EXPOLDB for RAB3A UniProtKB/Swiss-Prot: RAB3A_HUMAN, P20336Tissue specificity: Specifically expressed in brain |
Orthologs for RAB3A
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for RAB3A gene from 5/10 species (see all 10
)
About this table Species with no ortholog for RAB3A
ENSEMBL Gene Tree for RAB3A | Paralogs for RAB3A(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for RAB3A gene
- RAB3B2 RAB122 RAB3D2 RAB3C2
|
SNPs/Variants for RAB3A(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for RAB3A (up to first 250kb)
|
Disorders & Mutations for RAB3A
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 179490
2 Novoseek disease relationships for RAB3A gene
About this table
Human Genome Epidemiology Navigator: RAB3A (1 document) Tumor Gene Database: RAB3A
|
Medical News for RAB3A(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for RAB3A (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/90 PubMed articles for RAB3A gene (see all 90
):- Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A. (PubMed id 7991565)1, 3, 4 Farnsworth C.C.... Glomset J.A. (1994)
- Isoprenoid modification of rab proteins terminating in CC or CXC motifs. (PubMed id 1648736)1, 3, 4 Khosravi-Far R.... Der C.J. (1991)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)3, 4 Grimwood J.... Lucas S.M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Genomic organisation of the human cyclic AMP-specific phosphodiesterase PDE4C gene and its chromosomal localisation to 19p13.1, between RAB3A and JUND. (PubMed id 10574328)3, 4 Sullivan M.... Houslay M.D. (1999)
- Interaction cloning of Rabin3, a novel protein that associates with the Ras-like GTPase Rab3A. (PubMed id 7532276)2, 3 Brondyk W.H....Macara I.G. (1995)
- The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion. (PubMed id 2501306)3, 4 Zahraoui A.... Tavitian A. (1989)
- Chromosome mapping of the human ras-related rab3A gene to 19p13.2. (PubMed id 2687157)2, 3 Rousseau-Merck M.F....Berger R. (1989)
- Structural basis of Rab effector specificity: crystal structure of the small G protein Rab3A complexed with the effector domain of rabphilin-3A. (PubMed id 10025402)1, 3 Ostermeier C. and Brunger A.T. (1999)
- Membrane-permeant Rab3A triggers acrosomal exocytosis in living human sperm. (PubMed id 17625073)1, 3 Lopez C.I....Mayorga L.S. (2007)
|
Search for RAB3A
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing RAB3A
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing RAB3A
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RAB3A(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for RAB3A(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
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