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RAB3A Gene

protein-coding   GIFtS: 68
GCID: GC19M018307

RAB3A, Member RAS Oncogene Family

  See RAB3A-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RAB3A, Member RAS Oncogene Family1 2
RAS-Associated Protein RAB3A1 2
Ras-Related Protein Rab-3A2

External Ids:    HGNC: 97771   Entrez Gene: 58642   Ensembl: ENSG000001056497   OMIM: 1794905   UniProtKB: P203363   

Export aliases for RAB3A gene to outside databases

Previous GC identifers: GC19M018801 GC19M018699 GC19M018152 GC19M018168 GC19M017871


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RAB3A Gene:
RAB3A (RAB3A, member RAS oncogene family) is a protein-coding gene. Diseases associated with RAB3A include choroideremia. GO annotations related to this gene include protein C-terminus binding and GTP binding. An important paralog of this gene is RAB10.

UniProtKB/Swiss-Prot: RAB3A_HUMAN, P20336
Function: Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in
neurotransmitter release by regulating membrane flow in the nerve terminal

Gene Wiki entry for RAB3A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the RAB3A gene promoter:
         MEF-2A   ISGF-3   GCNF   GCNF-1   HOXA5   Pax-2   Pax-2a   GCNF-2   LCR-F1   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRAB3A promoter sequence
   Search Chromatin IP Primers for RAB3A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RAB3A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13.2

RAB3A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAB3A gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M018307:  view genomic region     (about GC identifiers)

Start:
18,307,594 bp from pter      End:
18,314,884 bp from pter
Size:
7,291 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RAB3A_HUMAN, P20336 (See protein sequence)
Recommended Name: Ras-related protein Rab-3A  
Size: 220 amino acids; 24984 Da
Subunit: Heterodimer with RIMS2. Part of a ternary complex involving PCLO and EPAC2. Interacts with RPH3A and
RPH3AL. Interacts with the exocyst complex through SEC15. Binds SYTL4 and RIMS1. Interacts with RAB3IP. Interacts
with SGSM1 and SGSM3 (By similarity)
Secondary accessions: A8K0J4 Q9NYE1

Explore the universe of human proteins at neXtProt for RAB3A: NX_P20336

Explore proteomics data for RAB3A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RAB3A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002857.1  
    ENSEMBL proteins: 
     ENSP00000222256   ENSP00000474603   ENSP00000472335  
    Reactome Protein details: P20336

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RAB: RAB, member RAS oncogene

    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR003579 Small_GTPase_Rab_type
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry P20336

    ProtoNet protein and cluster: P20336

    1 Blocks protein domain: IPB001806 Transforming protein P21 RAS signature

    UniProtKB/Swiss-Prot: RAB3A_HUMAN, P20336
    Similarity: Belongs to the small GTPase superfamily. Rab family


    Find genes that share domains with RAB3A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RAB3A_HUMAN, P20336
    Function: Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in
    neurotransmitter release by regulating membrane flow in the nerve terminal

         Genatlas biochemistry entry for RAB3A:
    RAB3A,Ras oncogene superfamily member,expressed synaptic vesicles, involved in calcium regulated
    exocytosis,expressed in parathyroid chief cells

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001671ATPase activator activity IEA--
    GO:0003924GTPase activity IMP10859313
    GO:0005515protein binding IPI10859313
    GO:0005525GTP binding IEA--
    GO:0008022protein C-terminus binding IEA--
         
    Find genes that share ontologies with RAB3A           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for RAB3A:
     Decreased CXCL12 induced migra  Decreased nuclei size in G2M  Increased circadian period len 

         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Rab3a):
     behavior/neurological  growth/size/body  homeostasis/metabolism  mortality/aging  nervous system 
     normal  respiratory system 

    Find genes that share phenotypes with RAB3A           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Rab3atm1Sud for RAB3A

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RAB3A
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    Selected qRT-PCR Assays for microRNAs that regulate RAB3A (see all 12):
    hsa-miR-142-3p hsa-miR-596 hsa-miR-549 hsa-miR-4271 hsa-miR-589* hsa-let-7a-2* hsa-let-7g* hsa-miR-625
    SwitchGear 3'UTR luciferase reporter plasmidRAB3A 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RAB3A_HUMAN, P20336: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton3
    cytosol3
    golgi apparatus2

    Gene Ontology (GO): Selected cellular component terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669acrosomal vesicle IEA--
    GO:0005622intracellular ----
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0005829cytosol IEA--

    Find genes that share ontologies with RAB3A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RAB3A About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Synaptic vesicle cycle
    Synaptic Vesicle Pathway0.50
    Synaptic vesicle cycle0.50
    2Neurotransmitter Release Cycle
    Serotonin Neurotransmitter Release Cycle0.40
    Glutamate Neurotransmitter Release Cycle0.00
    Neurotransmitter Release Cycle0.32
    Dopamine Neurotransmitter Release Cycle0.00
    Acetylcholine Neurotransmitter Release Cycle0.00
    Norepinephrine Neurotransmitter Release Cycle0.00
    GABA synthesis, release, reuptake and degradation0.00
    3Transmission across Chemical Synapses
    Transmission across Chemical Synapses0.72
    Neuronal System0.68
    4Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions0.36
    5Insulin secretion
    Insulin secretion0.36


    Find genes that share SuperPaths with RAB3A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for RAB3A
        Epithelial Tight Junctions

    1 Cell Signaling Technology (CST) Pathway for RAB3A
        Cytoskeletal Signaling

    2 BioSystems Pathways for RAB3A
        BDNF signaling pathway
    Synaptic Vesicle Pathway


    Selected Reactome Pathways for RAB3A (see all 6)
        Acetylcholine Neurotransmitter Release Cycle
    Glutamate Neurotransmitter Release Cycle
    Norepinephrine Neurotransmitter Release Cycle
    Dopamine Neurotransmitter Release Cycle
    GABA synthesis, release, reuptake and degradation


    2 Kegg Pathways  (Kegg details for RAB3A):
        Synaptic vesicle cycle
    Insulin secretion

        Pathway & Disease-focused RT2 Profiler PCR Array including RAB3A: 
              Synaptic Plasticity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RAB3A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RAB3A (P203362, 3 ENSP000002222564) via UniProtKB, MINT, STRING, and/or I2D (see all 45)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RIMS2Q9UQ263, ENSP000003862284I2D: score=5 STRING: ENSP00000390665 STRING: ENSP00000386228
    RPH3ALQ9UNE23, ENSP000003192104I2D: score=5 STRING: ENSP00000319210
    SYTL4Q96C243, ENSP000002630334I2D: score=3 STRING: ENSP00000263033
    CHMP243863, ENSP000003503864I2D: score=2 STRING: ENSP00000350386
    CHMLP263743, ENSP000003555114I2D: score=2 STRING: ENSP00000355511
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003016respiratory system process IEA--
    GO:0006184GTP catabolic process TAS2501306
    GO:0006886intracellular protein transport ----
    GO:0006913nucleocytoplasmic transport ----
    GO:0007005mitochondrion organization IEA--

    Find genes that share ontologies with RAB3A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RAB3A

    5 Novoseek inferred chemical compound relationships for RAB3A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 68.7 20 8886977 (3), 7926025 (3), 8387493 (2), 9252412 (1) (see all 9)
    gdp 65.2 8 19546222 (2), 9252412 (1), 7926025 (1), 8188702 (1) (see all 5)
    sucrose 5 1 8886977 (1)
    calcium 3.73 10 11522668 (3), 10954749 (2), 17625073 (2), 19546222 (1)
    norepinephrine 0 4 8636125 (2)



    Find genes that share compounds with RAB3A           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RAB3A gene: 
    NM_002866.4  

    Unigene Cluster for RAB3A:

    RAB3A, member RAS oncogene family
    Hs.27744  [show with all ESTs]
    Unigene Representative Sequence: NM_002866
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000222256(uc002nie.2) ENST00000464076 ENST00000481914 ENST00000515410

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    hsa-miR-142-3p hsa-miR-596 hsa-miR-549 hsa-miR-4271 hsa-miR-589* hsa-let-7a-2* hsa-let-7g* hsa-miR-625
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    Additional mRNA sequence: 

    AF254795.1 AF498931.1 AK289559.1 AK293467.1 BC011782.2 M28210.1 

    6 DOTS entries:

    DT.444206  DT.100653326  DT.100668937  DT.40110695  DT.95301547  DT.95171615 

    Selected AceView cDNA sequences (see all 124):

    AW163583 AA364643 BU739142 AW160374 BQ898770 BP360364 CA309409 BX442130 
    BM926739 CD615936 BX419052 NM_002866 BM673547 AW205498 AL534649 AW205866 
    BI917111 BC011782 BG222950 F07394 BM921884 BP362917 BM702574 BG819310 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for RAB3A    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b
    SP1:                    -           -                           
    SP2:                    -     -     -                           
    SP3:                                -                           
    SP4:                    -                                       


    ECgene alternative splicing isoforms for RAB3A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RAB3A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAACACTAC
    RAB3A Expression
    About this image


    RAB3A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Pancreas (Endocrine System)    fully expand to see all 2 entries
             Islets of Langerhans
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
    RAB3A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RAB3A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.27744

    UniProtKB/Swiss-Prot: RAB3A_HUMAN, P20336
    Tissue specificity: Specifically expressed in brain

        Pathway & Disease-focused RT2 Profiler PCR Array including RAB3A: 
              Synaptic Plasticity in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RAB3A gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rab3a1 , 5 RAB3A, member RAS oncogene family1, 5 89.24(n)1
    99.09(a)1
      8 (34.15 cM)5
    193391  NM_001166399.21  NP_001159871.11 
     707546795 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.213462 Xenopus laevis transcribed sequence with strong similarity more 80.97(n)    BX848352.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rab3ab1 RAB3A, member RAS oncogene family, b 80.61(n)
    94.09(a)
      550457  NM_001017761.1  NP_001017761.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rab33 neurotransmitter secretion RAB small
    monomeric more
    76(a)   47B7   --
    worm
    (Caenorhabditis elegans)
    Secernentea rab-33 synaptic vesicle-associated GTP-binding
    protein
    76(a)   II(5722291-5724698)   --


    ENSEMBL Gene Tree for RAB3A (if available)
    TreeFam Gene Tree for RAB3A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RAB3A gene
    RAB102  RAB3B2  RAB262  RAB8A2  RAB3D2  RAB372  RAB8B2  RAB1B2  
    RAB122  RAB1A2  RAB132  RAB3C2  
    Selected SIMAP similar genes for RAB3A using alignment to 3 protein entries:     RAB3A_HUMAN (see all proteins) (see all similar genes):
    RAB3C    RAB3B    RAB3D    rab1b    RAB8B    RAB13
    DKFZp686J06205    RAB10    RAB8A    RAB35    RAB1C    RAB15
    RAB1B    RAB12    RAB11A    RAB30    DKFZp686J07132    RAB11B

    Find genes that share paralogs with RAB3A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RAB3A (see all 176)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1932124101,2
    --18308164(+) GTGACA/GGGCTA 1 -- ut310--------
    rs1150502281,2
    C,F--18308210(+) GGGGCC/TGGGTC 1 -- ut311Minor allele frequency- T:0.04WA 118
    rs1996102411,2
    --18308265(+) GAAAGG/TGAGTG 1 -- ut310--------
    rs2003945671,2
    C--18308275(+) GGGATG/AGCTCT 1 -- ut311Minor allele frequency- A:0.00EU 1075
    rs129768171,2
    C,F,H--18308279(+) TGGCTT/CTCAGC 1 -- ut31 ese39Minor allele frequency- C:0.02EA NS NA 1250
    rs2020419061,2
    --18308342(+) CTTGGA/CGCCTG 2 A S mis10--------
    rs1401901981,2
    F--18308429(+) CTTGAC/TGTTAA 2 I V mis11Minor allele frequency- T:0.00NA 4550
    rs412781961,2
    C,F--18308430(+) TTGACG/ATTAAT 2 /N syn16Minor allele frequency- A:0.01NA NS EU 6051
    rs2012171501,2
    --18308475(+) CCTGTA/GGTCAG 1 -- int10--------
    rs81098071,2
    C,F,A,H--18308508(+) GGCCAC/TGCCCT 1 -- int119Minor allele frequency- T:0.20NS EA NA CSA WA 2346

    HapMap Linkage Disequilibrium report for RAB3A (18307594 - 18314884 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for RAB3A (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718286CNV Deletion23290073
    nsv911264CNV Loss21882294
    nsv911256CNV Loss21882294
    nsv911254CNV Loss21882294
    dgv3773n71CNV Loss21882294
    nsv911260CNV Loss21882294
    nsv833775CNV Loss17160897
    dgv3774n71CNV Loss21882294
    dgv576n67CNV Gain20364138
    dgv3777n71CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RAB3A
    DNA2.0 Custom Variant and Variant Library Synthesis for RAB3A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 179490    OMIM disorders: --

    1 disease for RAB3A:    
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    choroideremia

    1 disease from the University of Copenhagen DISEASES database for RAB3A:
    Choroideremia

    Find genes that share disorders with RAB3A           About GenesLikeMe

    2 Novoseek inferred disease relationships for RAB3A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alzheimers disease 12.3 1 11351135 (1)
    tumors 0 4 11074007 (1), 1384950 (1), 19212825 (1)

    Genetic Association Database (GAD): RAB3A
    Human Genome Epidemiology (HuGE) Navigator: RAB3A (1 document)
    Tumor Gene Database (TGDB): RAB3A

    Export disorders for RAB3A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RAB3A gene, integrated from 10 sources (see all 102):
    (articles sorted by number of sources associating them with RAB3A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A. (PubMed id 7991565)1, 2, 9 Farnsworth C.C.... Glomset J.A. (Proc. Natl. Acad. Sci. U.S.A. 1994)
    2. Isoprenoid modification of rab proteins terminating in CC or CXC motifs. (PubMed id 1648736)1, 2, 9 Khosravi-Far R.... Der C.J. (Proc. Natl. Acad. Sci. U.S.A. 1991)
    3. Variants in the RAB3A gene are not associated with mental retardation in the Chinese population. (PubMed id 16584842)1, 4 Sun Y....He L. (Neurosci. Lett. 2006)
    4. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Genomic organisation of the human cyclic AMP-specific phosphodiesterase PDE4C gene and its chromosomal localisation to 19p13.1, between RAB3A and JUND. (PubMed id 10574328)1, 2 Sullivan M.... Houslay M.D. (Cell. Signal. 1999)
    7. Interaction cloning of Rabin3, a novel protein that associates with the Ras-like GTPase Rab3A. (PubMed id 7532276)1, 3 Brondyk W.H....Macara I.G. (Mol. Cell. Biol. 1995)
    8. The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion. (PubMed id 2501306)1, 2 Zahraoui A.... Tavitian A. (J. Biol. Chem. 1989)
    9. Chromosome mapping of the human ras-related rab3A gene to 19p13.2. (PubMed id 2687157)1, 3 Rousseau-Merck M.F....Berger R. (Genomics 1989)
    10. Abnormal alpha-synuclein interactions with rab3a and rabphilin in diffuse Lewy body disease. (PubMed id 15207266)1, 9 DalfA^ E....Ferrer I. (Neurobiol. Dis. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
    Disorders
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5864 HGNC: 9777 AceView: RAB3A Ensembl:ENSG00000105649 euGenes: HUgn5864
    ECgene: RAB3A Kegg: 5864 H-InvDB: RAB3A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RAB3A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAB3A Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RAB3A gene:
    Search GeneIP for patents involving RAB3A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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