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Aliases for RAB3A Gene

Aliases for RAB3A Gene

  • RAB3A, Member RAS Oncogene Family 2 3 5
  • RAS-Associated Protein RAB3A 2

External Ids for RAB3A Gene

Previous GeneCards Identifiers for RAB3A Gene

  • GC19M018801
  • GC19M018699
  • GC19M018152
  • GC19M018307
  • GC19M017871

Summaries for RAB3A Gene

GeneCards Summary for RAB3A Gene

RAB3A (RAB3A, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Transmission across Chemical Synapses and Immune System. GO annotations related to this gene include GTP binding and protein C-terminus binding. An important paralog of this gene is RAB3C.

UniProtKB/Swiss-Prot for RAB3A Gene

  • Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal.

Gene Wiki entry for RAB3A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB3A Gene

Genomics for RAB3A Gene

Regulatory Elements for RAB3A Gene

Enhancers for RAB3A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F018289 1.6 FANTOM5 ENCODE 4.8 -88.2 -88163 6.1 CREB3L1 ZFP64 YBX1 DMAP1 YY1 ZNF143 ZNF548 SP3 TBX21 MEF2D ENSG00000268030 UPF1 ENSG00000268938 MVB12A COLGALT1 KIAA1683 JUND ELL ENSG00000268199 ENSG00000269191
GH19F017841 1 ENCODE 7 +361.8 361760 2.5 HDGF ATF1 PKNOX1 CREB3L1 SIN3A ZNF2 GLIS2 ZNF143 KLF7 ZNF263 INSL3 RAB3A JAK3 GC19M017837
GH19F018611 1.2 FANTOM5 ENCODE 1.7 -407.5 -407525 0.7 THRB ZNF48 RARA GLIS2 EGR1 EGR2 HMG20B SP3 SP5 PPARG TMEM59L GDF1 CRTC1 RAB3A PDE4C GC19P019197 RN7SL155P
GH19F018191 1.2 ENCODE 0.4 +10.7 10699 4.1 HDGF PKNOX1 MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ENSG00000268030 COLGALT1 UPF1 PDE4C MVB12A ENSG00000268938 ENSG00000268199 ENSG00000269191 PLVAP KXD1
GH19F018202 0.5 ENCODE 0.8 +1.4 1407 0.1 CTCF ZNF121 MLLT1 RAB3A MPV17L2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RAB3A on UCSC Golden Path with GeneCards custom track

Promoters for RAB3A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001816577 1074 401 PKNOX1 CBX3 SIN3A ARID4B RAD21 ZNF121 USF2 REST ZNF592 RAD51

Genomic Location for RAB3A Gene

Chromosome:
19
Start:
18,196,784 bp from pter
End:
18,204,074 bp from pter
Size:
7,291 bases
Orientation:
Minus strand

Genomic View for RAB3A Gene

Genes around RAB3A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB3A Gene

Proteins for RAB3A Gene

  • Protein details for RAB3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20336-RAB3A_HUMAN
    Recommended name:
    Ras-related protein Rab-3A
    Protein Accession:
    P20336
    Secondary Accessions:
    • A8K0J4
    • Q9NYE1

    Protein attributes for RAB3A Gene

    Size:
    220 amino acids
    Molecular mass:
    24984 Da
    Quaternary structure:
    • Heterodimer with RIMS2. Part of a ternary complex involving PCLO and EPAC2. Interacts with RPH3A and RPH3AL. Interacts with the exocyst complex through SEC15. Binds SYTL4 and RIMS1. Interacts with RAB3IP. Interacts with SGSM1 and SGSM3 (By similarity).

neXtProt entry for RAB3A Gene

Post-translational modifications for RAB3A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB3A Gene

No data available for DME Specific Peptides for RAB3A Gene

Domains & Families for RAB3A Gene

Gene Families for RAB3A Gene

Protein Domains for RAB3A Gene

Suggested Antigen Peptide Sequences for RAB3A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P20336

UniProtKB/Swiss-Prot:

RAB3A_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB3A: view

Function for RAB3A Gene

Molecular function for RAB3A Gene

GENATLAS Biochemistry:
RAB3A,Ras oncogene superfamily member,expressed synaptic vesicles, involved in calcium regulated exocytosis,expressed in parathyroid chief cells
UniProtKB/Swiss-Prot Function:
Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal.

Gene Ontology (GO) - Molecular Function for RAB3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001671 ATPase activator activity IEA --
GO:0003924 GTPase activity IMP 10859313
GO:0005515 protein binding IPI 10859313
GO:0005525 GTP binding IEA --
GO:0008022 protein C-terminus binding IEA --
genes like me logo Genes that share ontologies with RAB3A: view
genes like me logo Genes that share phenotypes with RAB3A: view

Animal Models for RAB3A Gene

MGI Knock Outs for RAB3A:

Animal Model Products

miRNA for RAB3A Gene

miRTarBase miRNAs that target RAB3A

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RAB3A

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RAB3A Gene

Localization for RAB3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB3A Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB3A gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 5
cytoskeleton 3
endosome 3
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for RAB3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005622 intracellular IEA --
GO:0005768 endosome IEA --
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane IEA,TAS --
genes like me logo Genes that share ontologies with RAB3A: view

Pathways & Interactions for RAB3A Gene

genes like me logo Genes that share pathways with RAB3A: view

Pathways by source for RAB3A Gene

Gene Ontology (GO) - Biological Process for RAB3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003016 respiratory system process IEA --
GO:0006810 transport IEA --
GO:0006887 exocytosis IEA --
GO:0007005 mitochondrion organization IEA --
GO:0007264 small GTPase mediated signal transduction IEA --
genes like me logo Genes that share ontologies with RAB3A: view

No data available for SIGNOR curated interactions for RAB3A Gene

Drugs & Compounds for RAB3A Gene

(3) Drugs for RAB3A Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for RAB3A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RAB3A: view

Transcripts for RAB3A Gene

Unigene Clusters for RAB3A Gene

RAB3A, member RAS oncogene family:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RAB3A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB3A Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b
SP1: - -
SP2: - - -
SP3: -
SP4: -

Relevant External Links for RAB3A Gene

GeneLoc Exon Structure for
RAB3A
ECgene alternative splicing isoforms for
RAB3A

Expression for RAB3A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RAB3A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB3A Gene

This gene is overexpressed in Brain - Cortex (x7.3), Brain - Frontal Cortex (BA9) (x6.9), Brain - Anterior cingulate cortex (BA24) (x5.8), and Brain - Hippocampus (x4.4).

Protein differential expression in normal tissues from HIPED for RAB3A Gene

This gene is overexpressed in Brain (31.7), Frontal cortex (13.2), and Retina (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RAB3A Gene



NURSA nuclear receptor signaling pathways regulating expression of RAB3A Gene:

RAB3A

SOURCE GeneReport for Unigene cluster for RAB3A Gene:

Hs.27744

mRNA Expression by UniProt/SwissProt for RAB3A Gene:

P20336-RAB3A_HUMAN
Tissue specificity: Specifically expressed in brain.
genes like me logo Genes that share expression patterns with RAB3A: view

No data available for Protein tissue co-expression partners for RAB3A Gene

Orthologs for RAB3A Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB3A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB3A 34 35
  • 100 (n)
oppossum
(Monodelphis domestica)
Mammalia RAB3A 35
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAB3A 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAB3A 34 35
  • 93.18 (n)
cow
(Bos Taurus)
Mammalia RAB3A 34 35
  • 91.67 (n)
mouse
(Mus musculus)
Mammalia Rab3a 34 16 35
  • 89.24 (n)
rat
(Rattus norvegicus)
Mammalia Rab3a 34
  • 88.48 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia rab3a 34
  • 80.15 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.21346 34
zebrafish
(Danio rerio)
Actinopterygii rab3aa 35
  • 87 (a)
OneToMany
rab3ab 34 35
  • 80.61 (n)
fruit fly
(Drosophila melanogaster)
Insecta Rab3 36 35
  • 76 (a)
worm
(Caenorhabditis elegans)
Secernentea rab-3 36 35
  • 76 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 77 (a)
OneToMany
Species where no ortholog for RAB3A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB3A Gene

ENSEMBL:
Gene Tree for RAB3A (if available)
TreeFam:
Gene Tree for RAB3A (if available)

Paralogs for RAB3A Gene

Paralogs for RAB3A Gene

genes like me logo Genes that share paralogs with RAB3A: view

Variants for RAB3A Gene

Sequence variations from dbSNP and Humsavar for RAB3A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1046565 -- 18,200,389(-) GGCGC(C/T)ATGGG reference, synonymous-codon
rs111370852 -- 18,201,250(+) ACAAC(-/A)AAAAA intron-variant
rs111585153 -- 18,199,761(+) TCAGG(G/T)GATCC intron-variant
rs111865479 -- 18,199,210(+) GGAGT(A/G)CAGTG intron-variant
rs112382185 -- 18,199,589(+) GGCAA(C/T)CTTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB3A Gene

Variant ID Type Subtype PubMed ID
nsv952420 CNV deletion 24416366
nsv833775 CNV loss 17160897
nsv819691 CNV gain 19587683
nsv1071516 CNV deletion 25765185
esv3643834 CNV gain 21293372
esv3643833 CNV loss 21293372
esv2718286 CNV deletion 23290073
dgv576n67 CNV gain 20364138

Variation tolerance for RAB3A Gene

Residual Variation Intolerance Score: 23.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.25; 5.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAB3A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAB3A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB3A Gene

Disorders for RAB3A Gene

Relevant External Links for RAB3A

Genetic Association Database (GAD)
RAB3A
Human Genome Epidemiology (HuGE) Navigator
RAB3A
Tumor Gene Database (TGDB):
RAB3A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAB3A

No disorders were found for RAB3A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB3A Gene

Publications for RAB3A Gene

  1. Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A. (PMID: 7991565) Farnsworth C.C. … Glomset J.A. (Proc. Natl. Acad. Sci. U.S.A. 1994) 3 4 22 64
  2. Isoprenoid modification of rab proteins terminating in CC or CXC motifs. (PMID: 1648736) Khosravi-Far R. … Der C.J. (Proc. Natl. Acad. Sci. U.S.A. 1991) 3 4 22 64
  3. Epac activates the small G proteins Rap1 and Rab3A to achieve exocytosis. (PMID: 19546222) Branham M.T. … Tomes C.N. (J. Biol. Chem. 2009) 3 22 64
  4. Membrane-permeant Rab3A triggers acrosomal exocytosis in living human sperm. (PMID: 17625073) Lopez C.I. … Mayorga L.S. (FASEB J. 2007) 3 22 64
  5. Variants in the RAB3A gene are not associated with mental retardation in the Chinese population. (PMID: 16584842) Sun Y. … He L. (Neurosci. Lett. 2006) 3 46 64

Products for RAB3A Gene

Sources for RAB3A Gene

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