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Aliases for RAB39A Gene

Aliases for RAB39A Gene

  • RAB39A, Member RAS Oncogene Family 2 3
  • RAB39, Member RAS Oncogene Family 2 3
  • Rab-Related GTP-Binding Protein 2 3
  • Rab-39 3 4
  • RAB39 3 4
  • Ras-Related Protein Rab-39A 3

External Ids for RAB39A Gene

Previous HGNC Symbols for RAB39A Gene

  • RAB39

Previous GeneCards Identifiers for RAB39A Gene

  • GC11P107799

Summaries for RAB39A Gene

GeneCards Summary for RAB39A Gene

RAB39A (RAB39A, Member RAS Oncogene Family) is a Protein Coding gene. GO annotations related to this gene include GTP binding. An important paralog of this gene is RAB42.

UniProtKB/Swiss-Prot for RAB39A Gene

  • Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in vesicular trafficking. Plays a role in the fusion of phagosomes with lysosomes.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB39A Gene

Genomics for RAB39A Gene

Genomic Location for RAB39A Gene

107,928,503 bp from pter
107,963,482 bp from pter
34,980 bases
Plus strand

Genomic View for RAB39A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAB39A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB39A Gene

No data available for Regulatory Elements for RAB39A Gene

Proteins for RAB39A Gene

  • Protein details for RAB39A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras-related protein Rab-39A
    Protein Accession:
    Secondary Accessions:
    • A8KAA4
    • Q8N6W2

    Protein attributes for RAB39A Gene

    217 amino acids
    Molecular mass:
    25007 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RAB39A Gene

Proteomics data for RAB39A Gene at MOPED

Post-translational modifications for RAB39A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB39A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RAB39A Gene

Domains for RAB39A Gene

Gene Families for RAB39A Gene

  • RAB :RAB, member RAS oncogene

Graphical View of Domain Structure for InterPro Entry



  • Q14964
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB39A: view

No data available for Suggested Antigen Peptide Sequences for RAB39A Gene

Function for RAB39A Gene

Molecular function for RAB39A Gene

UniProtKB/Swiss-Prot Function: Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in vesicular trafficking. Plays a role in the fusion of phagosomes with lysosomes.

Gene Ontology (GO) - Molecular Function for RAB39A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IBA --
GO:0005515 protein binding IPI 25416956
GO:0005525 GTP binding NAS 9119394
genes like me logo Genes that share ontologies with RAB39A: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RAB39A Gene

Localization for RAB39A Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB39A Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis.

Gene Ontology (GO) - Cellular Components for RAB39A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005737 cytoplasm --
GO:0005794 Golgi apparatus IBA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with RAB39A: view

No data available for Subcellular locations from COMPARTMENTS for RAB39A Gene

Pathways for RAB39A Gene

SuperPathways for RAB39A Gene

No Data Available

Gene Ontology (GO) - Biological Process for RAB39A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport IBA --
GO:0006913 nucleocytoplasmic transport --
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction --
genes like me logo Genes that share ontologies with RAB39A: view

No data available for Pathways by source for RAB39A Gene

Transcripts for RAB39A Gene

mRNA/cDNA for RAB39A Gene

(6) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RAB39A Gene

RAB39A, member RAS oncogene family:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAB39A Gene

No ASD Table

Relevant External Links for RAB39A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RAB39A Gene

mRNA expression in normal human tissues for RAB39A Gene

mRNA differential expression in normal tissues according to GTEx for RAB39A Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB39A Gene

SOURCE GeneReport for Unigene cluster for RAB39A Gene Hs.354906

genes like me logo Genes that share expressions with RAB39A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for RAB39A Gene

Orthologs for RAB39A Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB39A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RAB39A 35
  • 96.62 (n)
  • 95.28 (a)
RAB39A 36
  • 97 (a)
(Bos Taurus)
Mammalia RAB39 35
  • 95.39 (n)
  • 98.62 (a)
RAB39 36
  • 99 (a)
(Canis familiaris)
Mammalia RAB39 35
  • 92.01 (n)
  • 96.74 (a)
RAB39A 36
  • 55 (a)
(Mus musculus)
Mammalia Rab39 35
  • 91.4 (n)
  • 97.24 (a)
Rab39 16
Rab39 36
  • 97 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 94 (a)
-- 36
  • 89 (a)
(Rattus norvegicus)
Mammalia Rab39a 35
  • 91.4 (n)
  • 96.31 (a)
(Gallus gallus)
Aves RAB39A 36
  • 90 (a)
(Anolis carolinensis)
Reptilia RAB39A 36
  • 67 (a)
(Danio rerio)
Actinopterygii rab42b 36
  • 53 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rab39 36
  • 56 (a)
(Caenorhabditis elegans)
Secernentea rab-39 36
  • 48 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 61 (a)
Species with no ortholog for RAB39A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RAB39A Gene

Gene Tree for RAB39A (if available)
Gene Tree for RAB39A (if available)

Paralogs for RAB39A Gene Pseudogenes for RAB39A Gene

genes like me logo Genes that share paralogs with RAB39A: view

Variants for RAB39A Gene

Sequence variations from dbSNP and Humsavar for RAB39A Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs518739 -- 107,932,291(+) AGATT(G/T)GTATA intron-variant
rs554180 -- 107,929,059(-) GCGAG(A/G)ACGAC intron-variant
rs737173 -- 107,953,365(-) TCTAC(A/T)AACTC intron-variant
rs747145 -- 107,953,376(-) TCAAC(A/C)ATTCT intron-variant
rs963619 -- 107,954,109(-) CACAG(A/G)TATGT intron-variant

Relevant External Links for RAB39A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RAB39A Gene

Disorders for RAB39A Gene

No disorders were found for RAB39A Gene.

No data available for UniProtKB/Swiss-Prot for RAB39A Gene

Publications for RAB39A Gene

  1. Construction of a transcription map around the gene for ataxia telangiectasia; identification of at least four novel genes. (PMID: 9119394) Stankovic T. … Taylor A.M.R. (Genomics 1997) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes. (PMID: 21255211) Seto S. … Koide Y. (Traffic 2011) 3 4
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PMID: 23000965) Povlsen L.K. … Choudhary C. (Nat. Cell Biol. 2012) 3

Products for RAB39A Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate RAB39A
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for RAB39A
    • Block miRNA regulation of RAB39A using miScript Target Protectors

    Sources for RAB39A Gene

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