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RAB39 Gene

protein-coding GIFtS: 50

GC11P107305

RAB39, member RAS oncogene family
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
RAB39A ^³
Rab-39 ^³

Descriptions
RAB39, member RAS oncogene family ^²
rab-related GTP-binding protein ^²

External Ids
HGNC: 16521¹
Entrez Gene: 54734²
UniProtKB: Q14964³
Ensembl: ENSG00000179331⁷

Search outside databases for aliases for RAB39 gene

Previous GC identifers: GC11P109993 GC11P109155 GC11P107833 GC11P107336

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: RB39A_HUMAN, Q14964

Function: May be involved in vesicular trafficking

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the RAB39 gene

Ensembl cytogenetic band: 11q22.3 HGNC cytogenetic band: 11q22-q23

RAB39 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P107305: (about GC identifiers)

Start:	107,304,487 bp from pter
End:	107,339,418 bp from pter
Size:	34,932 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000011.8 NT_033899.7

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: RB39A_HUMAN, Q14964 (See protein sequence)

Recommended Name: Ras-related protein Rab-39A

Size: 217 amino acids; 25007 Da

Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)

Secondary accessions: Q8N6W2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_059986.1

ENSEMBL proteins:

ENSP00000322594

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (RAB39)
	Human Recombinant Proteins from Abnova (RAB39)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0005886	plasma membrane	IEA	--

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Antibodies for RAB39:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (RAB39), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (RAB39)
	Novus Biologicals Antibodies for RAB39

Assays for RAB39:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q14964

ProtoNet protein and cluster: Q14964

4 Blocks protein families:

IPB001806 Transforming protein P21 RAS signature

IPB002041 GTP-binding nuclear protein Ran

IPB003577 Ras small GTPase

IPB003578 Ras small GTPase

UniProtKB/Swiss-Prot: RB39A_HUMAN, Q14964

Similarity: Belongs to the small GTPase superfamily. Rab family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (RAB39)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (RAB39)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_084662

Applied Biosystems Silencer® siRNAs for RAB39

Sigma-Aldrich siRNA for RAB39

Sigma-Aldrich shRNA for RAB39

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for RAB39
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_017516
Myc/DDK tagged cDNA clone in CMV expression vector: NM_017516
untagged cDNA clone in CMV expression vector: NM_017516

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_017516

UniProtKB/Swiss-Prot: RB39A_HUMAN, Q14964

Function: May be involved in vesicular trafficking

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0005525	GTP binding	NAS	9119394

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007264	small GTPase mediated signal transduction	IEA	--
GO:0008150	biological_process	ND	--
GO:0015031	protein transport	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for RAB39

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for RAB39

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (RAB39)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (RAB39)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_084662

Sigma-Aldrich siRNA for RAB39

Sigma-Aldrich shRNA for RAB39

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_017516

REFSEQ mRNAs for RAB39 gene:

NM_017516.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_017516

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_017516
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_017516
                                 untagged cDNA clone in CMV expression vector: NM_017516

Additional cDNA sequence:

AK292969.1 BC028064.1 X99962.1

1 DOTS entry:

DT.91657574

6 AceView cDNA sequences:

CD675186 BC028064 BM723610 BI754838 NM_017516 X99962

highest scoring ESTs for RAB39:

BC028064 BI754838 X99962 BM723610 CD675186 CN315308 NM_017516 C20859 CR746988 CV030395

Unigene Cluster for RAB39:

RAB39, member RAS oncogene family

Hs.354906 [show with all ESTs]

Unigene Representative Sequence: NM_017516

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000320578

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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RAB39 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for RAB39

¹ / ²

1 probe-set matching RAB39 gene

	Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
	Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
	1554800_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AGCTGCCGTG

SOURCE GeneReport for Unigene cluster: Hs.354906

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for RAB39 gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
cow (Bos taurus)	RAB39¹	--	RAB39, member RAS oncogene family	95.39(n) 98.62(a)	541114 XM_614612.3 XP_614612.1
rat (Rattus norvegicus)	Rab39¹	--	RAB39, member RAS oncogene family	91.4(n) 96.31(a)	315668 XM_236242.4 XP_236242.4
mouse (Mus musculus)	Rab39^{1, 5}	9⁵	RAB39, member RAS oncogene family^{1, 5}	91.4(n)¹ 97.24(a)¹	270160¹ NM_175562.3¹ NP_780771.1¹ AB232635⁵ AK041076⁵ (see all 9)
chicken (Gallus gallus)	RAB39¹	--	RAB39, member RAS oncogene family	82.18(n) 89.58(a)	428085 XM_425643.2 XP_425643.2
fruit fly (Drosophila melanogaster)	CG12156³	7B7	GTP binding	54(a)	--

About this table Species with no ortholog for RAB39

ENSEMBL Gene Tree for RAB39

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for RAB39 gene

RAB39B²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/263 NCBI SNPs in RAB39 are shown (see all 263 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 48)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1532819^1,2	A,C,F,H,O	107304096(+)	`AACGAC/ATCTCA`	1	--	ng5¹		9		MN EU EA WA	1020
	rs4754282^1,2	A,C,F,H	107338755(+)	`GTATCA/GACTAG`	1	--	ut3¹ ese³		10		EA NA EU WA	810
	rs1532820^1,2	A,C,F,H	107304162(+)	`TTGCTG/ACTGTC`	1	--	ng5¹		5		MN EU EA WA	596
--	rs7107923^1,2	A,C,F	107339104(+)	`caggtG/Aattgt`	1	--	ut3¹		3		NA	142
--	rs1027733^1,2	A,C	107339235(+)	`ctcctC/Ggcctc`	1	--	ut3¹ ese³		0	--	--	--	--
--	rs1027734^1,2	A,C	107339317(+)	`CAGCAA/CATGTT`	1	--	ut3¹ ese³		0	--	--	--	--
--	rs10789646^1,2	A	107339333(+)	`GTTACA/GGTGTA`	1	--	ut3¹		0	--	--	--	--
--	rs10789645^1,2	A	107339318(+)	`AGCACA/CTGTTT`	1	--	ut3¹ ese³		0	--	--	--	--
	rs3132842^1,2	H	107303582(+)	`ATCAAG/AACAAG`	1	--	ng5¹		4		EU EA WA	418
--	rs3132843^1,2	H	107303587(+)	`GACAAG/AAAagc`	1	--	ng5¹		4		EU EA WA	418

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HapMap Linkage Disequilibrium images for RAB39 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

3 PubMed articles for RAB39 gene:

Construction of a transcription map around the gene for ataxia telangiectasia; identification of at least four novel genes. (PubMed id 9119394)^{2, 3, 4} Stankovic T.... Taylor A.M.R. (1997)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 54734	HGNC: 16521	AceView: RAB39	Ensembl:ENSG00000179331	euGenes: HUgn54734
ECgene: RAB39	H-InvDB: RAB39

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for RAB39	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for RAB39
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for RAB39:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for RAB39-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for RAB39		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for RAB39		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (RAB39)
	Antibodies (RAB39)
	Chimera RNAi (RAB39)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (RAB39)
	Antibodies (RAB39)

Search OriGene for RAB39

Search Tocris compounds for RAB39

	Drugs for RAB39
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for RAB39

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RAB39 Gene

protein-coding GIFtS: 50

Aliases &
Descriptions
for RAB39

Summaries
for RAB39

Genomic Location
for RAB39

Proteins
for RAB39

Protein Domains/
Families
for RAB39

Gene Function
for RAB39

Pathways & Interactions
for RAB39

Drugs & Compounds
for RAB39

Transcripts
for RAB39

Expression
for RAB39

Orthologs
for RAB39

Paralogs
for RAB39

SNPs/Variants
for RAB39

Disorders & Mutations
for RAB39

Medical News
for RAB39

Publications
for RAB39

Search for RAB39

Genome Databases showing RAB39

Other Databases showing RAB39

Specialized Databases showing RAB39

Licensable Technologies
for RAB39

Services
for RAB39

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

RAB39 Gene

protein-coding GIFtS: 50

Aliases & Descriptionsfor RAB39

Summariesfor RAB39

Genomic Locationfor RAB39

Proteinsfor RAB39

Protein Domains/Familiesfor RAB39

Gene Functionfor RAB39

Pathways & Interactionsfor RAB39

Drugs & Compoundsfor RAB39

Transcriptsfor RAB39

Expression for RAB39

Orthologsfor RAB39

Paralogsfor RAB39

SNPs/Variantsfor RAB39

Disorders & Mutationsfor RAB39

Medical Newsfor RAB39

Publicationsfor RAB39

Search for RAB39

Genome Databases showing RAB39

Other Databases showing RAB39

Specialized Databases showing RAB39

Licensable Technologiesfor RAB39

Servicesfor RAB39

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for RAB39

Summaries
for RAB39

Genomic Location
for RAB39

Proteins
for RAB39

Protein Domains/
Families
for RAB39

Gene Function
for RAB39

Pathways & Interactions
for RAB39

Drugs & Compounds
for RAB39

Transcripts
for RAB39

Expression
for RAB39

Orthologs
for RAB39

Paralogs
for RAB39

SNPs/Variants
for RAB39

Disorders & Mutations
for RAB39

Medical News
for RAB39

Publications
for RAB39

Licensable Technologies
for RAB39

Services
for RAB39