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Aliases for RAB38 Gene

Aliases for RAB38 Gene

  • RAB38, Member RAS Oncogene Family 2 3
  • Melanoma Antigen NY-MEL-1 3 4
  • Rab-Related GTP-Binding Protein 3
  • Ras-Related Protein Rab-38 3
  • NY-MEL-1 3
  • RrGTPbp 3

External Ids for RAB38 Gene

Summaries for RAB38 Gene

GeneCards Summary for RAB38 Gene

RAB38 (RAB38, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB38 include melanoma. Among its related pathways are Cytoskeletal Signaling. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB9A.

UniProtKB/Swiss-Prot for RAB38 Gene

  • May be involved in melanosomal transport and docking. Involved in the proper sorting of TYRP1. Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with ANKRD27 and VAMP7 (By similarity). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.

Gene Wiki entry for RAB38 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB38 Gene

Genomics for RAB38 Gene

Genomic Location for RAB38 Gene

Start:
88,113,242 bp from pter
End:
88,175,467 bp from pter
Size:
62,226 bases
Orientation:
Minus strand

Genomic View for RAB38 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAB38 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB38 Gene

Regulatory Elements for RAB38 Gene

Proteins for RAB38 Gene

  • Protein details for RAB38 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P57729-RAB38_HUMAN
    Recommended name:
    Ras-related protein Rab-38
    Protein Accession:
    P57729
    Secondary Accessions:
    • Q53XK7

    Protein attributes for RAB38 Gene

    Size:
    211 amino acids
    Molecular mass:
    23712 Da
    Quaternary structure:
    • Interacts with ANKRD27 (PubMed:19403694).

neXtProt entry for RAB38 Gene

Proteomics data for RAB38 Gene at MOPED

Post-translational modifications for RAB38 Gene

  • Although at least one in vitro system can process and methylate the prenylated C-terminal, in an in vitro system that normally express Rab-38 and in vivo the prenylated C-terminal is not proteolytically processed and not methylated.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB38 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RAB38 Gene

Domains for RAB38 Gene

Gene Families for RAB38 Gene

HGNC:
  • RAB :RAB, member RAS oncogene

Suggested Antigen Peptide Sequences for RAB38 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P57729

UniProtKB/Swiss-Prot:

RAB38_HUMAN
Family:
  • Belongs to the small GTPase superfamily. Rab family.:
    • P57729
genes like me logo Genes that share domains with RAB38: view

Function for RAB38 Gene

Molecular function for RAB38 Gene

UniProtKB/Swiss-Prot Function: May be involved in melanosomal transport and docking. Involved in the proper sorting of TYRP1. Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with ANKRD27 and VAMP7 (By similarity). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.

Gene Ontology (GO) - Molecular Function for RAB38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity NAS 10910072
GO:0005515 protein binding IPI 22511774
GO:0005525 GTP binding NAS 10910072
GO:0030742 GTP-dependent protein binding IPI 22511774
GO:0032403 protein complex binding --
genes like me logo Genes that share ontologies with RAB38: view
genes like me logo Genes that share phenotypes with RAB38: view

miRNA for RAB38 Gene

miRTarBase miRNAs that target RAB38

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RAB38 Gene

Localization for RAB38 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB38 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Melanosome. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB38 Gene COMPARTMENTS Subcellular localization image for RAB38 gene
Compartment Confidence
plasma membrane 5
cytosol 3
lysosome 2
vacuole 2
endosome 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RAB38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005737 cytoplasm --
GO:0005769 early endosome IDA 22511774
GO:0005783 endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with RAB38: view

Pathways for RAB38 Gene

SuperPathways for RAB38 Gene

Superpath Contained pathways
1 Cytoskeletal Signaling
genes like me logo Genes that share pathways with RAB38: view

Pathways by source for RAB38 Gene

1 Cell Signaling Technology pathway for RAB38 Gene

Gene Ontology (GO) - Biological Process for RAB38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport IBA --
GO:0006913 nucleocytoplasmic transport --
GO:0006996 organelle organization --
GO:0007165 signal transduction --
genes like me logo Genes that share ontologies with RAB38: view

Transcripts for RAB38 Gene

mRNA/cDNA for RAB38 Gene

Unigene Clusters for RAB38 Gene

RAB38, member RAS oncogene family:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAB38 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d
SP1: -
SP2: - -
SP3:
SP4: - -

Relevant External Links for RAB38 Gene

GeneLoc Exon Structure for
RAB38
ECgene alternative splicing isoforms for
RAB38

Expression for RAB38 Gene

mRNA expression in normal human tissues for RAB38 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB38 Gene

This gene is overexpressed in Esophagus - Mucosa (9.9), Skin - Not Sun Exposed (Suprapubic) (7.5), Skin - Sun Exposed (Lower leg) (7.3), and Adrenal Gland (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB38 Gene

SOURCE GeneReport for Unigene cluster for RAB38 Gene Hs.591975

mRNA Expression by UniProt/SwissProt for RAB38 Gene

P57729-RAB38_HUMAN
Tissue specificity: Expressed in melanocytes
genes like me logo Genes that share expressions with RAB38: view

Orthologs for RAB38 Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB38 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB38 35
  • 99.53 (n)
  • 100 (a)
RAB38 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RAB38 35
  • 93.03 (n)
  • 96.52 (a)
RAB38 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAB38 35
  • 94.31 (n)
  • 96.68 (a)
RAB38 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rab38 35
  • 90.68 (n)
  • 97.16 (a)
Rab38 16
Rab38 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAB38 36
  • 42 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAB38 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rab38 35
  • 91.15 (n)
  • 96.21 (a)
chicken
(Gallus gallus)
Aves RAB38 35
  • 79.23 (n)
  • 85.99 (a)
RAB38 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAB38 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rab38 35
  • 76.46 (n)
  • 82.46 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6944 35
zebrafish
(Danio rerio)
Actinopterygii rab38a 35
  • 74.13 (n)
  • 78.57 (a)
rab38a 36
  • 79 (a)
OneToMany
rab38b 36
  • 74 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta ltd 36
  • 19 (a)
OneToMany
Rab-RP1 37
  • 72 (a)
worm
(Caenorhabditis elegans)
Secernentea glo-1 36
  • 46 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8865 35
Species with no ortholog for RAB38:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB38 Gene

ENSEMBL:
Gene Tree for RAB38 (if available)
TreeFam:
Gene Tree for RAB38 (if available)

Paralogs for RAB38 Gene

Paralogs for RAB38 Gene

Pseudogenes.org Pseudogenes for RAB38 Gene

genes like me logo Genes that share paralogs with RAB38: view

Variants for RAB38 Gene

Sequence variations from dbSNP and Humsavar for RAB38 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs9144 -- 88,113,589(+) ATATA(C/T)TGAAA utr-variant-3-prime
rs188559 -- 88,160,693(-) ccagc(C/T)acatc intron-variant
rs190998 -- 88,170,468(-) ATAGG(A/G)TTCGG intron-variant
rs302643 -- 88,177,396(+) GGAGA(A/C)TATCT upstream-variant-2KB
rs302648 -- 88,169,611(+) GGAGA(C/T)TGAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB38 Gene

Variant ID Type Subtype PubMed ID
nsv527214 CNV Loss 19592680
esv2664391 CNV Deletion 23128226
esv8555 CNV Loss 19470904
nsv898081 CNV Gain 21882294
esv275284 CNV Gain+Loss 21479260

Relevant External Links for RAB38 Gene

HapMap Linkage Disequilibrium report
RAB38

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB38 Gene

Disorders for RAB38 Gene

(1) MalaCards Diseases for RAB38 Gene

Search for RAB38 Gene in MalaCards »

(2) University of Copenhagen DISEASES for RAB38 Gene

(1) Novoseek inferred disease relationships for RAB38 Gene

Disease -log(P) Hits PubMed IDs
albinism oculocutaneous 92.7 1

Relevant External Links for RAB38

Genetic Association Database (GAD)
RAB38
Human Genome Epidemiology (HuGE) Navigator
RAB38
genes like me logo Genes that share disorders with RAB38: view

No data available for UniProtKB/Swiss-Prot for RAB38 Gene

Publications for RAB38 Gene

  1. Serological cloning of a melanocyte rab guanosine 5'-triphosphate- binding protein and a chromosome condensation protein from a melanoma complementary DNA library. (PMID: 10910072) Jaeger D. … Chen Y.-T. (Cancer Res. 2000) 2 3 4 23
  2. Proteomic analysis of early melanosomes: identification of novel melanosomal proteins. (PMID: 12643545) Basrur V. … Appella E. (J. Proteome Res. 2003) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Characterization of the human RAB38 and RAB7 genes: exclusion of new major pathological loci for Japanese OCA. (PMID: 12850305) Suzuki T. … Tomita Y. (J. Dermatol. Sci. 2003) 3 23
  5. Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes. (PMID: 21255211) Seto S. … Koide Y. (Traffic 2011) 3 4

Products for RAB38 Gene

Sources for RAB38 Gene

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