RAB38 Gene
protein-coding GIFtS: 55
GCID: GC11M087846
|
|
RAB38, member RAS oncogene family
| |
Aliases
for RAB38 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| RAB38, Member RAS Oncogene Family1 2 | | NY-MEL-11 2 | | Melanoma Antigen NY-MEL-12 3 | | Rab-Related GTP-Binding Protein2 | | Ras-Related Protein Rab-382 | | RrGTPbp1 |
Export aliases for RAB38 gene to outside databasesPrevious GC identifers: GC11M090169 GC11M089393 GC11M088030 GC11M087534 GC11M087486 GC11M084086 |
Summaries
for RAB38 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: RAB38_HUMAN, P57729Function: May be involved in melanosomal transport and docking. Involved in the proper sorting of TYRP1. Plays a rolein the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis
Gene Wiki entry for RAB38
|
Genomic Views
for RAB38 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RAB38 gene promoter:
STAT5A HNF-3beta PPAR-gamma1 POU2F1 POU2F1a POU2F1b STAT3 PPAR-gamma2 POU2F1c Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for RAB38
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB38 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q14 Ensembl cytogenetic band: 11q14.2 HGNC cytogenetic band: 11q14RAB38 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M087846: view genomic region
(about GC identifiers)
Start:
|
87,846,431 bp from pter |
End:
|
87,908,635 bp from pter |
Size:
|
62,205 bases |
Orientation:
|
minus strand |
|
Proteins
for RAB38 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RAB38_HUMAN, P57729 (See
protein sequence)Recommended Name: Ras-related protein Rab-38 Size: 211 amino acids; 23712 Da
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Melanosome. Cytoplasmic vesicle,phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side (By similarity). Note=Recruited tophagosomes containing S.aureus or M.tuberculosis
Secondary accessions: Q53XK7Explore the universe of human proteins at neXtProt for RAB38: NX_P57729
Post-translational modifications:
Although at least one in vitro system can process and methylate the prenylated C-terminal, in an in vitro system thatnormally express Rab-38 and in vivo the prenylated C-terminal is not proteolytically processed and not methylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P57729
RAB38 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_071732.1
ENSEMBL proteins: ENSP00000243662 ENSP00000435340 ENSP00000433317
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
RAB38 for ontologies About GeneDecksing
RAB38 Antibody Products:
Assay Products for RAB38: |
Protein
Domains /
Families
for RAB38 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RAB38 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P57729ProtoNet protein and cluster: P57729 1 Blocks protein family: IPB001806 Transforming protein P21 RAS signature
UniProtKB/Swiss-Prot: RAB38_HUMAN, P57729Similarity: Belongs to the small GTPase superfamily. Rab family |
Function
for RAB38 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RAB38_HUMAN, P57729Function: May be involved in melanosomal transport and docking. Involved in the proper sorting of TYRP1. Plays a rolein the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAB38 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAB38 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB38 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
RAB38 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for RAB38:
Animal Models:
7 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Rab38):
RAB38 for phenotypes About GeneDecksing
|
Pathways & Interactions
for RAB38 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cytoskeletal Signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Cell Signaling Technology (CST) Pathway for RAB38
RAB38 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAB38
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/7 Interacting proteins for RAB38 (P577293 ENSP000002436624) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
RAB38 for ontologies About GeneDecksing
|
Drugs & Compounds
for RAB38 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RAB38
Search CenterWatch for drugs/clinical trials and news about RAB38
|
Transcripts
for RAB38 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RAB38 gene: NM_022337.2 Unigene Cluster for RAB38: RAB38, member RAS oncogene family Hs.591975 [show with all ESTs]Unigene Representative Sequence: NM_0223373 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000243662(uc001pcj.2) ENST00000531138 ENST00000526372
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAB38 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAB38 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RAB38 (NM_022337) | | | DNA2.0 Custom Codon Optimized Gene
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Additional cDNA sequence: AF136172.1 AF235022.1 BC015808.1 BT009842.1 3 DOTS entries: DT.70103105 DT.91670331 DT.95372185 24/65 AceView cDNA sequences (see all 65): W94393 AI017581 CA443207 AL546159 BG260462 CR615812 AA164284 CA443345 N42447 AI765363 BE736962 AF235022 BQ233094 AI334984 CD365214 BG766060 AI354903 BC015808 AA885230 BE274396 BM972943 N20169 AW518279 BT009842
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for RAB38 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d |
|---|
|
| SP1: | | | | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | | | | | | | | |
ECgene alternative splicing isoforms for RAB38
|
Expression
for RAB38 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RAB38 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAATATATAT
About this image
See RAB38 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RAB38
SOURCE GeneReport for Unigene cluster: Hs.591975
UniProtKB/Swiss-Prot: RAB38_HUMAN, P57729Tissue specificity: Expressed in melanocytes
SABiosciences Custom PCR Arrays for RAB38
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAB38
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB38 |
Orthologs
for RAB38 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RAB38 gene from 6/21 species (see all 21) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
RAB381 |
RAB38, member RAS oncogene family |
79.29(n)
86.41(a) |
|
428095 XM_425653.2 XP_425653.2 |
lizard
(Anolis carolinensis) |
Reptilia |
RAB386 |
-- |
79(a) |
1 ↔ 1 |
3(199557000-199570080) |
African clawed frog
(Xenopus laevis) |
Amphibia |
BC053811.12 |
-- |
77.48(n) |
|
BC053811.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
rab38a1 |
RAB38a, member RAS oncogene family |
74.13(n)
78.57(a) |
|
100003274 XM_001342839.2 XP_001342875.2 |
honey bee
(Apis mellifera) |
Insecta |
-- |
-- |
44(a) |
possible ortholog |
GroupUn.70(7198-10407) |
worm
(Caenorhabditis elegans) |
Secernentea |
glo-16 |
Gut granule LOss family member (glo-1) |
45(a) |
possible ortholog |
X(9872852-9882156) |
ENSEMBL Gene Tree for RAB38 (if available)
TreeFam Gene Tree for RAB38 (if available) |
Paralogs
for RAB38 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RAB38 gene
- RAB9A2 RAB7A2 RAB9B2 RAB322 RAB7L12
18/61 SIMAP similar genes for RAB38 using alignment to 3 protein entries: RAB38_HUMAN (see all proteins)
(see all similar genes):RAB32 RAB6A' RAB7L1 RAB11A RAB7A RAB34
RANP1 RAB6A RAB8B RAB19 RAB11B RAB13
RAB25 RAB28 RAB6B RAB43 RAB18 RAB1A
RAB38 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for RAB38
PGOHUM00000237033 PGOHUM00000237035
|
Genomic Variants
for RAB38 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RAB38 (87846431 - 87908635 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RAB38
1 CNV: 61168 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAB38 |
|
Disorders
/ Diseases
for RAB38 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RAB38 for disorders About GeneDecksing
OMIM gene information: 606281
OMIM disorders: --
6  diseases for RAB38: About MalaCardsplatelet storage pool deficiency hermansky-pudlak syndrome oculocutaneous albinism melanoma
albinism multiple sclerosis
3 diseases from the University of Copenhagen DISEASES database for RAB38:Hermansky-Pudlak syndrome Oculocutaneous albinism Platelet storage pool deficiency 1 Novoseek disease relationship for RAB38 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| albinism oculocutaneous |
92.7 |
1 |
18413250 (1) |
Human Genome Epidemiology (HuGE) Navigator: RAB38 (1 document)
Export disorders for RAB38 gene to outside databases
|
Publications
for RAB38 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RAB38 gene, integrated from 9 sources (see all 23):
(articles sorted by number of sources associating them with RAB38) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Serological cloning of a melanocyte rab guanosine 5'-triphosphate- binding protein and a chromosome condensation protein from a melanoma complementary DNA library. (PubMed id 10910072)1, 2, 3, 9 Jaeger D.... Chen Y.-T. (2000)
- Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Proteomic analysis of early melanosomes: identification of novel melanosomal proteins. (PubMed id 12643545)1, 2 Basrur V.... Appella E. (2003)
- Characterization of the human RAB38 and RAB7 genes: exclusion of new major pathological loci for Japanese OCA. (PubMed id 12850305)1, 9 Suzuki T....Tomita Y. (2003)
- BLOC-2, AP-3, and AP-1 proteins function in concert wi th Rab38 and Rab32 proteins to mediate protein trafficking to lysosome-related o rganelles. (PubMed id 22511774)1 Bultema J.J....Di Pietro S.M. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes. (PubMed id 21255211)2 Seto S.... Koide Y. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
|
External Searches for RAB38 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RAB38 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RAB38 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RAB38 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for RAB38 gene:
Search GeneIP for patents involving RAB38
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RAB38 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| | | | Search Tocris compounds for RAB38 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | RAB38 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB38 |
|  |  |  | | | | Search ThermoFisher Antibodies for RAB38 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB38 |
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