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Aliases & Descriptions for RAB37
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases FLJ30284 2 FLJ32507 2 Rab37-like 2
Descriptions RAB37, member RAS oncogene family 2 RAB37, member of RAS oncogene family 2
Search outside databases for aliases for RAB37 genePrevious GC identifers: GC17P073131 GC17P073264 GC17P073263
Summaries for RAB37 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for RAB37 : Rab proteins are low molecular mass GTPases that are critical regulators of vesicle trafficking.For additional background information on Rab proteins, see MIM 179508.[supplied by OMIM] Gene Wiki entry for RAB37
Genomic Location for RAB37
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the RAB37 gene Entrez Gene cytogenetic band: 17q25.1 Ensembl cytogenetic band: 17q25.1 HGNC cytogenetic band: 17q25.2 RAB37 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure
GeneLoc location for GC17P070178:
(about GC identifiers )
Start:
70,178,312 bp from pter
End:
70,255,069 bp from pter
Size:
76,758 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000017.9 NT_010641.15 Proteins for RAB37
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: RAB37_HUMAN, Q96AX2 (See
protein sequence )Recommended Name: Ras-related protein Rab-37 Size : 223 amino acids; 24815 Da
Subcellular location : Cytoplasmic vesicle. Note=Secretory granules (By similarity)
REFSEQ proteins (2 alternative transcripts):
NP_001006639.1 NP_783865.1 ENSEMBL proteins: ENSP00000311970 ENSP00000341354 ENSP00000376393 ENSP00000376391 ENSP00000376390 ENSP00000376389 ENSP00000383934 ENSP00000376388 ENSP00000376387 Human Recombinant Proteins                OriGene Purified Recombinant Human Proteins (see all 2 ): RAB37 2 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for RAB37: Assays for RAB37:
Protein
Domains/ Families for RAB37(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q96AX2 ProtoNet protein and cluster: Q96AX2
1 Blocks protein family : IPB001806 Transforming protein P21 RAS signature UniProtKB/Swiss-Prot: RAB37_HUMAN, Q96AX2 Similarity : Belongs to the small GTPase superfamily. Rab family
Gene Function for RAB37
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_001006637 Applied Biosystems Silencer ® siRNAs for RAB37 Sigma-Aldrich siRNA for RAB37 Sigma-Aldrich shRNA for RAB37 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001006638                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001006638                                  untagged cDNA clones in CMV expression vector (see all 3 ): AK098068  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001006637 2 Gene Ontology (GO) molecular function terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0000166 nucleotide binding
IEA -- GO:0005525 GTP binding
IEA --
About this table
Pathways & Interactions for RAB37
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for RAB37 3 Interacting proteins for RAB37 (ENSP00000311970 3 ) via UniProtKB, MINT, and/or STRING About this table 2 Gene Ontology (GO) biological process terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0007264 small GTPase mediated signal transduction
IEA -- GO:0015031 protein transport
IEA --
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Drugs & Compounds for RAB37 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Enzo Life Sciences drugs & compounds for RAB37
Browse Tocris compounds for RAB37
Transcripts for RAB37(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_001006637 Sigma-Aldrich siRNA for RAB37 Sigma-Aldrich shRNA for RAB37 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001006638 NM_175738
REFSEQ mRNAs for RAB37 gene (2 alternative transcripts): NM_001006638.1 NM_175738.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001006638 NM_175738
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001006638                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001006638                                  untagged cDNA clones in CMV expression vector (see all 3 ): AK098068  
Additional cDNA sequence: AK054846.1 AK057069.1 AK098068.1 AK127073.1 AK290202.1 AK296062.1 AK296172.1 AK298033.1 AK303442.1 BC040547.1 CR601310.1
12 DOTS entries : DT.101979436 DT.40123007 DT.100698980 DT.120912026 DT.92047341 DT.100819720 DT.95372825 DT.100819714 DT.70100539 DT.120912024 DT.120912205 DT.120938773
24/67 AceView cDNA sequences (see all 67
):BQ183276 BG283602 AK054846 AK057069 BM706070 BQ188402 CR601310 AK098068 BC016615 BM921365 AI864721 CK299601 AW768344 AF188522 BX391966 BX342476 BX328183 BI819064 AA806096 BQ028124 BI603529 AK127073 BG759655 BX351009
highest scoring ESTs for RAB37 :AA321438 AA324998 AA631787 AA878511 AK098068 AK127073 AW955318 BC040547 BG256040 BM151381
Unigene Cluster for RAB37: RAB37, member RAS oncogene family Hs.592097 [show with all ESTs ] Unigene Representative Sequence: AK127073 GeneLoc Exon Structure 5/10 Alternative Splicing Database (ASD) splice patterns (SP) for RAB37 (see all 10
) ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b · 12c · 12d · 12e ^ 13 SP1 :                           -   -   -       -       -   -   -     SP2 :         -   -   -   -   -           -   -   -       -               SP3 :                           -   -   -       -               SP4 :         -   -   -   -   -           -   -   -                     SP5 :                 -           -   -   -       -              
About this scheme ECgene alternative splicing isoforms for RAB37 9 Ensembl transcripts including schematic representations : ENST00000310725
ENST00000340415
ENST00000392617
ENST00000392615
ENST00000392614
ENST00000392613
ENST00000402449
ENST00000392612
ENST00000392610
Expression for RAB37
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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RAB37 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for RAB37 1 / 2 / 3
3 probe-sets matching RAB37 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: ACCTGCAGGCSOURCE GeneReport for Unigene cluster: Hs.592097
Orthologs for RAB37
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for RAB37 gene from 5/7 species (see all 7
)
About this table Species with no ortholog for RAB37 ENSEMBL Gene Tree for RAB37 Paralogs for RAB37 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for RAB37 gene RAB27A 2 RAB26 2 RAB27B 2
SNPs/Variants for RAB37 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for RAB37 (up to first 250kb)
Disorders & Mutations for RAB37
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 609956
Medical News for RAB37 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for RAB37 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10 PubMed articles for RAB37 gene : The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 3, 4 Ota T....Sugano S. (2004) Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801) 3, 4 Gevaert K.... Vandekerckhove J. (2003) Rab37 is a novel mast cell specific GTPase localized to secretory granules. (PubMed id 10722846) 2, 3 Masuda E.S....Scheller R.H. (2000) Involvement of TMEM22 overexpression in the growth of renal cell carcinoma cells. (PubMed id 19148500) 1, 3 Dobashi S....Nakamura Y. (2009) Frequent down-regulation of hRAB37 in metastatic tumor by genetic and epigenetic mechanisms in lung cancer. (PubMed id 18687502) 3 Wu C.Y....Hsu M.T. (2009) Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514) 3 Rual J.F....Vidal M. (2005) Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46. (PubMed id 15308636) 3 Breuza L....Hauri H.P. (2004) Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2. (PubMed id 12578829) 3 Fukuda M. (2003) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 3 Strausberg R.L....Marra M.A. (2002)
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Genome Databases showing RAB37
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing RAB37
(According to HUGE )
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Specialized Databases showing RAB37 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for RAB37 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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