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Aliases for RAB37 Gene

Aliases for RAB37 Gene

  • RAB37, Member RAS Oncogene Family 2 3 5

External Ids for RAB37 Gene

Previous GeneCards Identifiers for RAB37 Gene

  • GC17P073131
  • GC17P073264
  • GC17P073263
  • GC17P070178
  • GC17P072666
  • GC17P068076

Summaries for RAB37 Gene

Entrez Gene Summary for RAB37 Gene

  • Rab proteins are low molecular mass GTPases that are critical regulators of vesicle trafficking. For additional background information on Rab proteins, see MIM 179508.[supplied by OMIM, Apr 2006]

GeneCards Summary for RAB37 Gene

RAB37 (RAB37, Member RAS Oncogene Family) is a Protein Coding gene. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB3B.

Gene Wiki entry for RAB37 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB37 Gene

Genomics for RAB37 Gene

Regulatory Elements for RAB37 Gene

Enhancers for RAB37 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RAB37 on UCSC Golden Path with GeneCards custom track

Genomic Location for RAB37 Gene

74,670,578 bp from pter
74,747,335 bp from pter
76,758 bases
Plus strand

Genomic View for RAB37 Gene

Genes around RAB37 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB37 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB37 Gene

Proteins for RAB37 Gene

  • Protein details for RAB37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras-related protein Rab-37
    Protein Accession:
    Secondary Accessions:
    • A8MXF5
    • A8MYT0
    • Q8IWA7

    Protein attributes for RAB37 Gene

    223 amino acids
    Molecular mass:
    24815 Da
    Quaternary structure:
    • Interacts with RIMS1.

    Alternative splice isoforms for RAB37 Gene


neXtProt entry for RAB37 Gene

Proteomics data for RAB37 Gene at MOPED

Post-translational modifications for RAB37 Gene

  • Ubiquitination at Lys 115 and Lys 189
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RAB37 Gene

Domains & Families for RAB37 Gene

Gene Families for RAB37 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Rab family.
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB37: view

Function for RAB37 Gene

genes like me logo Genes that share phenotypes with RAB37: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RAB37

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB37 Gene

Localization for RAB37 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB37 Gene

Cytoplasmic vesicle. Note=Secretory granules. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for RAB37 Gene COMPARTMENTS Subcellular localization image for RAB37 gene
Compartment Confidence
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for RAB37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IDA 15308636
GO:0016023 cytoplasmic, membrane-bounded vesicle IEA --
genes like me logo Genes that share ontologies with RAB37: view

Pathways & Interactions for RAB37 Gene

SuperPathways for RAB37 Gene

No Data Available

Interacting Proteins for RAB37 Gene

Gene Ontology (GO) - Biological Process for RAB37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with RAB37: view

No data available for Pathways by source and SIGNOR curated interactions for RAB37 Gene

Drugs & Compounds for RAB37 Gene

No Compound Related Data Available

Transcripts for RAB37 Gene

Unigene Clusters for RAB37 Gene

RAB37, member RAS oncogene family:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAB37 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b · 12c · 12d · 12e ^ 13
SP1: - - - - - - -
SP2: - - - - - - - - -
SP3: - - - -
SP4: - - - - - - - -
SP5: - - - - -
SP6: - - - - - - -
SP7: - - - - -
SP8: -
SP9: -
SP10: - -

Relevant External Links for RAB37 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RAB37 Gene

mRNA expression in normal human tissues for RAB37 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB37 Gene

This gene is overexpressed in Brain - Cerebellum (x11.0), Brain - Cerebellar Hemisphere (x10.7), and Whole Blood (x9.4).

Protein differential expression in normal tissues from HIPED for RAB37 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (39.3), Platelet (14.0), and Brain (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for RAB37 Gene

SOURCE GeneReport for Unigene cluster for RAB37 Gene Hs.351413

genes like me logo Genes that share expression patterns with RAB37: view

Protein tissue co-expression partners for RAB37 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for RAB37 Gene

Orthologs for RAB37 Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB37 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia RAB37 35
  • 89.64 (n)
  • 91.44 (a)
RAB37 36
  • 83 (a)
(Mus musculus)
Mammalia Rab37 35
  • 88.94 (n)
  • 93.72 (a)
Rab37 16
Rab37 36
  • 86 (a)
(Pan troglodytes)
Mammalia RAB37 35
  • 96.71 (n)
  • 95.96 (a)
RAB37 36
  • 84 (a)
(Rattus norvegicus)
Mammalia LOC100364984 35
  • 88.89 (n)
  • 94.14 (a)
(Bos Taurus)
Mammalia RAB37 36
  • 79 (a)
(Monodelphis domestica)
Mammalia RAB37 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia RAB37 36
  • 75 (a)
(Gallus gallus)
Aves RAB37 36
  • 64 (a)
(Anolis carolinensis)
Reptilia RAB37 36
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rab37 35
  • 70.33 (n)
  • 75.12 (a)
Str.14110 35
(Danio rerio)
Actinopterygii zgc:112183 35
  • 72.22 (n)
  • 75.98 (a)
RAB37 36
  • 68 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rab26 36
  • 31 (a)
(Caenorhabditis elegans)
Secernentea rab-37 35
  • 57.8 (n)
  • 57.45 (a)
rab-37 36
  • 47 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
Species with no ortholog for RAB37:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB37 Gene

Gene Tree for RAB37 (if available)
Gene Tree for RAB37 (if available)

Paralogs for RAB37 Gene Pseudogenes for RAB37 Gene

genes like me logo Genes that share paralogs with RAB37: view

Variants for RAB37 Gene

Sequence variations from dbSNP and Humsavar for RAB37 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs34215331 - 74,745,080(+) CCATC(A/C/G)CCAAG reference, missense
rs1026074 -- 74,715,289(+) GTGGG(C/T)GTGCA intron-variant
rs1056359 -- 74,745,719(-) CGGCC(C/G)CCCAA utr-variant-3-prime
rs2121646 -- 74,724,589(+) tgaat(C/T)cgaaa intron-variant
rs1868057 -- 74,720,763(+) GACAG(C/G)CTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB37 Gene

Variant ID Type Subtype PubMed ID
dgv372n27 CNV Gain 19166990
nsv517569 CNV Gain+Loss 19592680
esv2751770 CNV Gain 17911159
esv33995 CNV Loss 17666407
nsv2140 CNV Loss 18451855
esv4044 CNV Deletion 18987735
esv8799 CNV Loss 19470904
esv2716232 CNV Deletion 23290073
esv2574609 CNV Insertion 19546169
nsv908743 CNV Loss 21882294

Variation tolerance for RAB37 Gene

Residual Variation Intolerance Score: 79.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.35; 26.72% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RAB37 Gene

Disorders for RAB37 Gene

Relevant External Links for RAB37

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RAB37 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB37 Gene

Publications for RAB37 Gene

  1. Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study. (PMID: 20031577) Danik J.S. … Ridker P.M. (Circ Cardiovasc Genet 2009) 3 48 67
  2. Involvement of TMEM22 overexpression in the growth of renal cell carcinoma cells. (PMID: 19148500) Dobashi S. … Nakamura Y. (Oncol. Rep. 2009) 3 23
  3. Rab37 is a novel mast cell specific GTPase localized to secretory granules. (PMID: 10722846) Masuda E.S. … Scheller R.H. (FEBS Lett. 2000) 2 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. Small GTPase Rab37 targets tissue inhibitor of metalloproteinase 1 for exocytosis and thus suppresses tumour metastasis. (PMID: 25183545) Tsai C.H. … Wang Y.C. (Nat Commun 2014) 3

Products for RAB37 Gene

Sources for RAB37 Gene