Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RAB37 Gene

Aliases for RAB37 Gene

  • RAB37, Member RAS Oncogene Family 2 3

External Ids for RAB37 Gene

Previous GeneCards Identifiers for RAB37 Gene

  • GC17P073131
  • GC17P073264
  • GC17P073263
  • GC17P070178
  • GC17P072666
  • GC17P068076

Summaries for RAB37 Gene

Entrez Gene Summary for RAB37 Gene

  • Rab proteins are low molecular mass GTPases that are critical regulators of vesicle trafficking. For additional background information on Rab proteins, see MIM 179508.[supplied by OMIM, Apr 2006]

GeneCards Summary for RAB37 Gene

RAB37 (RAB37, Member RAS Oncogene Family) is a Protein Coding gene. GO annotations related to this gene include GTP binding. An important paralog of this gene is RAB1A.

Gene Wiki entry for RAB37 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB37 Gene

Genomics for RAB37 Gene

Regulatory Elements for RAB37 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RAB37 Gene

Start:
74,670,578 bp from pter
End:
74,747,335 bp from pter
Size:
76,758 bases
Orientation:
Plus strand

Genomic View for RAB37 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAB37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB37 Gene

Proteins for RAB37 Gene

  • Protein details for RAB37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96AX2-RAB37_HUMAN
    Recommended name:
    Ras-related protein Rab-37
    Protein Accession:
    Q96AX2
    Secondary Accessions:
    • A8MXF5
    • A8MYT0
    • Q8IWA7

    Protein attributes for RAB37 Gene

    Size:
    223 amino acids
    Molecular mass:
    24815 Da
    Quaternary structure:
    • Interacts with RIMS1.

    Alternative splice isoforms for RAB37 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAB37 Gene

Proteomics data for RAB37 Gene at MOPED

Post-translational modifications for RAB37 Gene

  • Ubiquitination at Lys80, Lys115, and Lys189
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RAB37 Gene

Domains for RAB37 Gene

Gene Families for RAB37 Gene

HGNC:
  • RAB :RAB, member RAS oncogene

Graphical View of Domain Structure for InterPro Entry

Q96AX2

UniProtKB/Swiss-Prot:

RAB37_HUMAN :
  • Q96AX2
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB37: view

Function for RAB37 Gene

Gene Ontology (GO) - Molecular Function for RAB37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IBA --
GO:0005515 protein binding IPI 25416956
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RAB37: view

Phenotypes for RAB37 Gene

GenomeRNAi human phenotypes for RAB37:
genes like me logo Genes that share phenotypes with RAB37: view

Animal Model Products

CRISPR Products

miRNA for RAB37 Gene

miRTarBase miRNAs that target RAB37

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RAB37 Gene

Localization for RAB37 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB37 Gene

Cytoplasmic vesicle. Note=Secretory granules. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB37 Gene COMPARTMENTS Subcellular localization image for RAB37 gene
Compartment Confidence
cytosol 3
nucleus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RAB37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005737 cytoplasm --
GO:0005768 endosome IBA --
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IDA 15308636
genes like me logo Genes that share ontologies with RAB37: view

Pathways for RAB37 Gene

SuperPathways for RAB37 Gene

No Data Available

Interacting Proteins for RAB37 Gene

Gene Ontology (GO) - Biological Process for RAB37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport IBA --
GO:0006904 vesicle docking involved in exocytosis IBA --
GO:0006913 nucleocytoplasmic transport --
GO:0007165 signal transduction --
genes like me logo Genes that share ontologies with RAB37: view

No data available for Pathways by source for RAB37 Gene

Transcripts for RAB37 Gene

Unigene Clusters for RAB37 Gene

RAB37, member RAS oncogene family:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAB37

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for RAB37

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB37 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b · 12c · 12d · 12e ^ 13
SP1: - - - - - - -
SP2: - - - - - - - - -
SP3: - - - -
SP4: - - - - - - - -
SP5: - - - - -
SP6: - - - - - - -
SP7: - - - - -
SP8: -
SP9: -
SP10: - -

Relevant External Links for RAB37 Gene

GeneLoc Exon Structure for
RAB37
ECgene alternative splicing isoforms for
RAB37

Expression for RAB37 Gene

mRNA expression in normal human tissues for RAB37 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB37 Gene

This gene is overexpressed in Brain - Cerebellum (11.0), Brain - Cerebellar Hemisphere (10.7), and Whole Blood (9.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB37 Gene

SOURCE GeneReport for Unigene cluster for RAB37 Gene Hs.351413

genes like me logo Genes that share expressions with RAB37: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for RAB37 Gene

Orthologs for RAB37 Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB37 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB37 35
  • 96.71 (n)
  • 95.96 (a)
RAB37 36
  • 84 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RAB37 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAB37 35
  • 89.64 (n)
  • 91.44 (a)
RAB37 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rab37 35
  • 88.94 (n)
  • 93.72 (a)
Rab37 16
Rab37 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAB37 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAB37 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100364984 35
  • 88.89 (n)
  • 94.14 (a)
chicken
(Gallus gallus)
Aves RAB37 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAB37 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rab37 35
  • 70.33 (n)
  • 75.12 (a)
Str.14110 35
zebrafish
(Danio rerio)
Actinopterygii RAB37 36
  • 68 (a)
OneToOne
zgc:112183 35
  • 72.22 (n)
  • 75.98 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rab26 36
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rab-37 35
  • 57.8 (n)
  • 57.45 (a)
rab-37 36
  • 47 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
OneToMany
Species with no ortholog for RAB37:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB37 Gene

ENSEMBL:
Gene Tree for RAB37 (if available)
TreeFam:
Gene Tree for RAB37 (if available)

Paralogs for RAB37 Gene

Paralogs for RAB37 Gene

Pseudogenes.org Pseudogenes for RAB37 Gene

genes like me logo Genes that share paralogs with RAB37: view

Variants for RAB37 Gene

Sequence variations from dbSNP and Humsavar for RAB37 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs495713 -- 74,676,064(-) CCCCA(G/T)ACCAT intron-variant
rs1026074 -- 74,715,289(+) GTGGG(C/T)GTGCA intron-variant
rs1056359 -- 74,745,719(-) CGGCC(C/G)CCCAA utr-variant-3-prime
rs1868057 -- 74,720,763(+) GACAG(C/G)CTTTT intron-variant
rs2034309 -- 74,691,926(+) AGTGG(C/T)GCGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB37 Gene

Variant ID Type Subtype PubMed ID
dgv372n27 CNV Gain 19166990
nsv517569 CNV Gain+Loss 19592680
esv2751770 CNV Gain 17911159
esv33995 CNV Loss 17666407
nsv2140 CNV Loss 18451855
esv4044 CNV Deletion 18987735
esv8799 CNV Loss 19470904
esv2716232 CNV Deletion 23290073
esv2574609 CNV Insertion 19546169
nsv908743 CNV Loss 21882294

Relevant External Links for RAB37 Gene

HapMap Linkage Disequilibrium report
RAB37

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB37 Gene

Disorders for RAB37 Gene

Relevant External Links for RAB37

Genetic Association Database (GAD)
RAB37
genes like me logo Genes that share disorders with RAB37: view

No data available for UniProtKB/Swiss-Prot for RAB37 Gene

Publications for RAB37 Gene

  1. Involvement of TMEM22 overexpression in the growth of renal cell carcinoma cells. (PMID: 19148500) Dobashi S. … Nakamura Y. (Oncol. Rep. 2009) 3 23
  2. Rab37 is a novel mast cell specific GTPase localized to secretory granules. (PMID: 10722846) Masuda E.S. … Scheller R.H. (FEBS Lett. 2000) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study. (PMID: 20031577) Danik J.S. … Ridker P.M. (Circ Cardiovasc Genet 2009) 3 48
  5. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K. … Vandekerckhove J. (Nat. Biotechnol. 2003) 3 4

Products for RAB37 Gene

Sources for RAB37 Gene

Back to Top

Content