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RAB37 Gene

protein-coding   GIFtS: 57

GC17P070178
RAB37, member RAS oncogene family
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
FLJ30284 2
FLJ32507 2
Rab37-like 2
Descriptions
RAB37, member RAS oncogene family 2
RAB37, member of RAS oncogene family 2
External Ids
HGNC: 302681
Entrez Gene: 3266242
UniProtKB: Q96AX23
Ensembl: ENSG000001727947
Search outside databases for aliases for RAB37 gene

Previous GC identifers: GC17P073131 GC17P073264 GC17P073263

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for RAB37:
Rab proteins are low molecular mass GTPases that are critical regulators of vesicle trafficking.
For additional background information on Rab proteins, see MIM 179508.[supplied by OMIM]

Gene Wiki entry for RAB37
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the RAB37 gene  

Entrez Gene cytogenetic band: 17q25.1   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25.2

RAB37 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P070178:     (about GC identifiers)

Start:
70,178,312 bp from pter
End:
70,255,069 bp from pter
Size:
76,758 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000017.9  NT_010641.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: RAB37_HUMAN, Q96AX2 (See protein sequence)
Recommended Name: Ras-related protein Rab-37  
Size: 223 amino acids; 24815 Da
Subcellular location: Cytoplasmic vesicle. Note=Secretory granules (By similarity)

REFSEQ proteins (2 alternative transcripts): 
NP_001006639.1  NP_783865.1  


ENSEMBL proteins: 
ENSP00000311970 ENSP00000341354 ENSP00000376393 ENSP00000376391 ENSP00000376390 ENSP00000376389 
ENSP00000383934 ENSP00000376388 ENSP00000376387 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Sigma-Aldrich AQUA Peptides for RAB37  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (RAB37)
Human Recombinant Proteins from Abnova (RAB37)
               OriGene Purified Recombinant Human Proteins (see all 2): RAB37  

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005793 ER-Golgi intermediate compartment IDA15308636
GO:0031410 cytoplasmic vesicle IEA--
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Antibodies for RAB37: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Antibodies from Abcam (RAB37), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (RAB37)
Novus Biologicals Antibodies for RAB37

Assays for RAB37: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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4 InterPro domains/families:
 IPR001806 Ras_GTPase
 IPR005225 Small_GTP_bd
 IPR003579 GTPase_Rab
 IPR013753 Ras


   GeneDecks  RAB37 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q96AX2

ProtoNet protein and cluster: Q96AX2

1 Blocks protein family: IPB001806 Transforming protein P21 RAS signature

UniProtKB/Swiss-Prot: RAB37_HUMAN, Q96AX2
Similarity: Belongs to the small GTPase superfamily. Rab family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (RAB37)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001006637

              Applied Biosystems Silencer® siRNAs for RAB37

              Sigma-Aldrich siRNA for RAB37  
                     Sigma-Aldrich shRNA for RAB37  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for RAB37
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001006638
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001006638
                                 untagged cDNA clones in CMV expression vector (see all 3): AK098068 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_001006637

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0000166 nucleotide binding IEA--
GO:0005525 GTP binding IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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 Gene Network CentralTM Interacting Genes and Proteins Network for  RAB37 


3 Interacting proteins for RAB37 (ENSP000003119703) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
RIMS1ENSP000002648393STRING (score=.807)
MLPHENSP000002646053STRING (score=.7)
--ENSP000003038183STRING (score=.939)
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2 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA--
GO:0015031 protein transport IEA--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for RAB37
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for RAB37

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (RAB37)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001006637

              Sigma-Aldrich siRNA for RAB37  
                     Sigma-Aldrich shRNA for RAB37  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001006638  NM_175738  

REFSEQ mRNAs for RAB37 gene (2 alternative transcripts): 

NM_001006638.1   NM_175738.3   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001006638  NM_175738  

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001006638
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001006638
                                 untagged cDNA clones in CMV expression vector (see all 3): AK098068 

Additional cDNA sequence: 

AK054846.1 AK057069.1 AK098068.1 AK127073.1 AK290202.1 AK296062.1 AK296172.1 AK298033.1 
AK303442.1 BC040547.1 CR601310.1 

12 DOTS entries:

DT.101979436  DT.40123007  DT.100698980  DT.120912026  DT.92047341  DT.100819720  DT.95372825  DT.100819714 
DT.70100539  DT.120912024  DT.120912205  DT.120938773 

24/67 AceView cDNA sequences (see all 67 ):

BQ183276 BG283602 AK054846 AK057069 BM706070 BQ188402 CR601310 AK098068 
BC016615 BM921365 AI864721 CK299601 AW768344 AF188522 BX391966 BX342476 
BX328183 BI819064 AA806096 BQ028124 BI603529 AK127073 BG759655 BX351009 

highest scoring ESTs for RAB37:

AA321438 AA324998 AA631787 AA878511 AK098068 AK127073 AW955318 BC040547 BG256040 BM151381 

Unigene Cluster for RAB37:

RAB37, member RAS oncogene family
Hs.592097  [show with all ESTs]
Unigene Representative Sequence: AK127073


GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for RAB37 (see all 10 )

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b · 12c · 12d · 12e ^ 13
SP1:                                                                                -     -     -                 -                 -     -     -         
SP2:                          -     -     -     -     -                             -     -     -                 -                                       
SP3:                                                                                -     -     -                 -                                       
SP4:                          -     -     -     -     -                             -     -     -                                                         
SP5:                                                  -                             -     -     -                 -                                       

About this scheme

ECgene alternative splicing isoforms for RAB37

9 Ensembl transcripts including schematic representations:
ENST00000310725  ENST00000340415  ENST00000392617  ENST00000392615  ENST00000392614  ENST00000392613  
ENST00000402449  ENST00000392612  ENST00000392610  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

RAB37 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for RAB37

1 / 2 / 3

3 probe-sets matching RAB37 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
47429_at2, 3 U95-B 1 1.00 1.00 1.00 1.00 AA324998 0.80 1.00 0.91 1

228113_at2, 3 U133-B 1 1.00 1.00 -- -- R62453 0.60 1.00 0.82 1

228113_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  RAB37 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: ACCTGCAGGC

SOURCE GeneReport for Unigene cluster: Hs.592097
(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for RAB37 gene from 5/7 species (see all 7 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
RAB371   -- RAB37, member RAS oncogene family 89.64(n)
91.44(a)
483298  XM_540417.2  XP_540417.2 
chimpanzee
(Pan troglodytes)
RAB371   -- RAB37, member RAS oncogene family 95.37(n)
94.17(a)
735694  XM_001135458.1  XP_001135458.1 
cow
(Bos taurus)
RAB371   -- RAB37, member RAS oncogene family 89.24(n)
93.27(a)
613954  XM_864786.2  XP_869879.2 
mouse
(Mus musculus)
Rab371, 5 115
RAB37, member of RAS oncogene family1, 5 88.79(n)1
93.27(a)1
582221  NM_021411.31  NP_067386.21 
 AB2326335  AF2335825  (see all 17)
worm
(Caenorhabditis elegans)
rab-371   -- RAB family 57.98(n)
57.45(a)
180696  NM_001047829.1  NP_001041294.1 
About this table        Species with no ortholog for RAB37

ENSEMBL Gene Tree for RAB37
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for RAB37 gene
RAB27A2  RAB262  RAB27B2  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/221 NCBI SNPs in RAB37 are shown (see all 221 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 88)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 17 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs22801771,2
C,F,H70179115(-) CTGAGA/CGTTTC 1 -- ut51 ese313Minor allele frequency- N:0.00EA NA EU WA 2300
rs99040781,2
C,F,H70178615(+) TGCTGG/AAGAGA 1 -- ng519Minor allele frequency- A:0.28EU EA WA NA 2240
rs342153311,2
C,F70252814(+) CCATCG/CCCAAG 2 P/A mis15Minor allele frequency- C:0.03NA EU EA WA 476
--
rs72121781,2
A,C70254079(+) CAGCCC/GCCGAA 2 -- ut31 int10--------
rs360933861,2
F70253070(+) CAGGCG/AGATGA 2 A/A syn11Minor allele frequency- A:0.04NA 76
rs65017341,2
A,C,F,H70247224(+) CACTTT/CAGTAT 2 -- int17Minor allele frequency- C:0.47EU EA NA 662
--
rs80710121,2
A,C,F,H70182945(+) gaggaT/Cgaatc 1 -- int14Minor allele frequency- C:0.45EU EA WA 414
rs80733631,2
A,C,F,H70230255(+) agtcaG/Actgct 1 -- int18Minor allele frequency- A:0.18EU EA WA NA 1958
rs98943041,2
A,C,F,H70188695(+) TCACAA/TGCTCC 1 -- int15Minor allele frequency- T:0.46EU EA WA NA 1818
rs28916031,2
A,C,F,H70190060(+) tctctG/Ctctct 1 -- int14Minor allele frequency- C:0.15EU EA WA 418
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HapMap Linkage Disequilibrium images for RAB37 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 609956

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10 PubMed articles for RAB37 gene:
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 326624 HGNC: 30268 AceView: RAB37 Ensembl:ENSG00000172794 euGenes: HUgn326624
ECgene: RAB37 H-InvDB: RAB37
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

NameDescription
ATLAS Chromosomes in Cancer entry for RAB37 Genetics and Cytogenetics in Oncology and Haematology
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for RAB37:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
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  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for RAB37-related products

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 Predesigned and custom siRNAs for RAB37 Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Proteins for RAB37
 Lentivirus-delivered shRNAs for RAB37 Browse small molecules at Sigma-Aldrich
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 Tagged/untagged cDNA clones
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 Purified proteins from HEK293T cells
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 shRNA in GFP-retroviral vector
 Search Tocris compounds for RAB37




 Drugs for RAB37
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 Antibodies for RAB37

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