RAB36 Gene
protein-coding GIFtS: 50
GCID: GC22P023487
|
|
RAB36, member RAS oncogene family
| |
Aliases
for RAB36 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| RAB36, Member RAS Oncogene Family1 2 | | Ras-Related Protein Rab-362 | | Small GTP-Binding Protein Rab362 |
Export aliases for RAB36 gene to outside databasesPrevious GC identifers: GC22P020186 GC22P021812 GC22P006455 |
Summaries
for RAB36 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: RAB36_HUMAN, O95755Function: Protein transport. Probably involved in vesicular traffic (By similarity)
Gene Wiki entry for RAB36
|
Genomic Views
for RAB36 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011520.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RAB36 gene promoter:
ER-alpha TBP Elk-1 AML1a Egr-1 GCNF FOXJ2 (long isoform) GCNF-1 c-Myb GCNF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for RAB36
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB36 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q11.22 Ensembl cytogenetic band: 22q11.22 HGNC cytogenetic band: 22q11.22RAB36 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22P023487: view genomic region
(about GC identifiers)
Start:
|
23,487,513 bp from pter |
End:
|
23,506,537 bp from pter |
Size:
|
19,025 bases |
Orientation:
|
plus strand |
|
Proteins
for RAB36 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RAB36_HUMAN, O95755 (See
protein sequence)Recommended Name: Ras-related protein Rab-36 Size: 333 amino acids; 36322 Da
Subcellular location: Golgi apparatus membrane; Lipid-anchor
Secondary accessions: Q2M390 Q7Z4A9 Q9UHP5Alternative splicing: 2 isoforms: O95755-1 O95755-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for RAB36: NX_O95755
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O95755
RAB36 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_004905.2
ENSEMBL proteins: ENSP00000263116 ENSP00000343494 ENSP00000397594
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
RAB36 for ontologies About GeneDecksing
RAB36 Antibody Products:
Assay Products for RAB36: |
Protein
Domains /
Families
for RAB36 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RAB36 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O95755ProtoNet protein and cluster: O95755 5 Blocks protein families: IPB001806 Transforming protein P21 RAS signature IPB002041 GTP-binding nuclear protein Ran IPB003577 Ras small GTPase IPB003578 Ras small GTPase IPB006688 ADP-ribosylation factor
UniProtKB/Swiss-Prot: RAB36_HUMAN, O95755Similarity: Belongs to the small GTPase superfamily. Rab family |
Function
for RAB36 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RAB36_HUMAN, O95755Function: Protein transport. Probably involved in vesicular traffic (By similarity) Genatlas biochemistry entry for RAB36:RAB6,Ras oncogene superfamily member,involved in vesicular trafficking associated with intra-Golgi transport in aregion deleted in malignant rhabdoid tumors but not involved in tumorigenesis,potential contributor,like RAB6
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAB36 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAB36
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RAB36 (NM_004914) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RAB36 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB36 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB36 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005525 | GTP binding |
IEA | -- |
RAB36 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for RAB36:
|
Pathways & Interactions
for RAB36 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RAB36
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for RAB36 (ENSP000002631164) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007264 | small GTPase mediated signal transduction |
IEA | -- | | GO:0015031 | protein transport |
IEA | -- |
RAB36 for ontologies About GeneDecksing
|
Drugs & Compounds
for RAB36 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RAB36
Search CenterWatch for drugs/clinical trials and news about RAB36
|
Transcripts
for RAB36 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RAB36 gene: NM_004914.2 Unigene Cluster for RAB36: RAB36, member RAS oncogene family Hs.369557 [show with all ESTs]Unigene Representative Sequence: AB0230613 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000263116(uc002zwv.1 uc010gtw.1) ENST00000341989 ENST00000420895
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAB36 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAB36
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RAB36 (NM_004914) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RAB36 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB36 |
Additional cDNA sequence: AB023061.1 AF133588.1 AK296052.1 AY336745.1 BC017436.1 BC104989.1 BC104991.1 CR456553.1 7 DOTS entries: DT.91639279 DT.120677454 DT.120677789 DT.101985575 DT.40271688 DT.91956824 DT.92008610 6 AceView cDNA sequences: CR456553 NM_004914 AF133588 AB023061 AY336745 BC017436
GeneLoc Exon Structure
|
Expression
for RAB36 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RAB36 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGGACTGTC
About this image
See RAB36 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RAB36
SOURCE GeneReport for Unigene cluster: Hs.369557
UniProtKB/Swiss-Prot: RAB36_HUMAN, O95755Tissue specificity: Ubiquitously present in all tissues examined
SABiosciences Custom PCR Arrays for RAB36
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAB36
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RAB36 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAB36 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAB36 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB36 |
Orthologs
for RAB36 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RAB36 gene from 4/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Rab361 , 5 |
RAB36, member RAS oncogene family1, 5 |
85.66(n)1
88.3(a)1 |
|
10 (38.49 cM)5
768771 NM_029781.31 NP_084057.11
750370585 |
chicken
(Gallus gallus) |
Aves |
RAB361 |
RAB36, member RAS oncogene family |
70.43(n)
71.8(a) |
|
416953 XM_415245.3 XP_415245.3 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.156262 |
Transcribed sequence with moderate similarity to protein more |
69.69(n) |
|
BM342307.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG79803
RabX51 |
small monomeric GTPase3
CG7980-PB1 |
52(a)3
55.17(n)1
49.5(a)1 |
|
62A103
382091 NM_139387.21 NP_647644.21 |
ENSEMBL Gene Tree for RAB36 (if available)
TreeFam Gene Tree for RAB36 (if available) |
Paralogs
for RAB36 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RAB36 gene
- RAB342
18/46 SIMAP similar genes for RAB36 using alignment to 2 protein entries: RAB36_HUMAN (see all proteins)
(see all similar genes):RAB34 RAB1A RAB1B RAB8B RAB35 RAB11A
RAB43 RAB4B RAB7A RAB13 RAB10 RAB11B
RAB15 RAB19 RAB37 RAN RANP1 DKFZp686J07132
RAB36 for paralogs About GeneDecksing
|
Genomic Variants
for RAB36 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RAB36 (23487513 - 23506537 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RAB36
1 CNV: 48008 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAB36 |
|
Disorders
/ Diseases
for RAB36 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RAB36 for disorders About GeneDecksing
OMIM gene information: 605662
OMIM disorders: --
2  diseases for RAB36: About MalaCardsrhabdoid tumors rhabdoid cancer
Export disorders for RAB36 gene to outside databases
|
Publications
for RAB36 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RAB36 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with RAB36) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and characterization of a novel Rab-family gene, Rab36, within the region at 22q11.2 that is homozygously deleted in malignant rhabdoid tumors. (PubMed id 9920784)1, 2, 3 Mori T.... Inazawa J. (1999)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
- Isolation of genes from the rhabdoid tumor deletion region in chromosome band 22q11.2. (PubMed id 10607907)1, 2 Zhou J.-Y.... Biegel J.A. (2000)
- The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 3 Dunham I....O'Brien K.P. (1999)
- RUTBC2 protein, a Rab9A effector and GTPase-activating protein for Rab36. (PubMed id 22637480)1 Nottingham R.M....Pfeffer S.R. (2012)
- Rab36 regulates the spatial distribution of late endo somes and lysosomes through a similar mechanism to Rab34. (PubMed id 19961360)1 Chen L....Wang T. (2010)
- Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity. (PubMed id 16923123)1 Itoh T.... Fukuda M. (2006)
- A two-dimensional electrophoresis reference map of human ovary. (PubMed id 16021519)1 Wang L....Sha J.H. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for RAB36 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RAB36 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RAB36 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RAB36 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for RAB36 gene:
Search GeneIP for patents involving RAB36
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RAB36 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RAB36 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAB36 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAB36 | | | OriGene Protein Over-expression Lysate for RAB36 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RAB36 | | OriGene 3'-UTR Clone for RAB36 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAB36 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAB36 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for RAB36 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RAB36 | | OriGene Custom Protein Services for RAB36 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RAB36 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAB36 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB36 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAB36 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAB36 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAB36 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for RAB36 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | RAB36 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB36 |
|  |  |  | | | | Search ThermoFisher Antibodies for RAB36 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB36 |
|
|
|
|
