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Aliases for RAB36 Gene

Aliases for RAB36 Gene

  • RAB36, Member RAS Oncogene Family 2 3

External Ids for RAB36 Gene

Previous GeneCards Identifiers for RAB36 Gene

  • GC22P020186
  • GC22P021812
  • GC22P023487
  • GC22P006455

Summaries for RAB36 Gene

GeneCards Summary for RAB36 Gene

RAB36 (RAB36, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB36 include rhabdoid cancer. GO annotations related to this gene include GTP binding. An important paralog of this gene is RAB41.

UniProtKB/Swiss-Prot for RAB36 Gene

  • Protein transport. Probably involved in vesicular traffic (By similarity).

Gene Wiki entry for RAB36 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB36 Gene

Genomics for RAB36 Gene

Regulatory Elements for RAB36 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RAB36 Gene

Start:
23,145,326 bp from pter
End:
23,164,350 bp from pter
Size:
19,025 bases
Orientation:
Plus strand

Genomic View for RAB36 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAB36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB36 Gene

Proteins for RAB36 Gene

  • Protein details for RAB36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95755-RAB36_HUMAN
    Recommended name:
    Ras-related protein Rab-36
    Protein Accession:
    O95755
    Secondary Accessions:
    • Q2M390
    • Q7Z4A9
    • Q9UHP5

    Protein attributes for RAB36 Gene

    Size:
    333 amino acids
    Molecular mass:
    36322 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RAB36 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAB36 Gene

Proteomics data for RAB36 Gene at MOPED

Post-translational modifications for RAB36 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB36 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RAB36 Gene

Domains for RAB36 Gene

Gene Families for RAB36 Gene

HGNC:
  • RAB :RAB, member RAS oncogene

Suggested Antigen Peptide Sequences for RAB36 Gene

Graphical View of Domain Structure for InterPro Entry

O95755

UniProtKB/Swiss-Prot:

RAB36_HUMAN :
  • O95755
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB36: view

Function for RAB36 Gene

Molecular function for RAB36 Gene

GENATLAS Biochemistry:
RAB6,Ras oncogene superfamily member,involved in vesicular trafficking associated with intra-Golgi transport in a region deleted in malignant rhabdoid tumors but not involved in tumorigenesis,potential contributor,like RAB6
UniProtKB/Swiss-Prot Function:
Protein transport. Probably involved in vesicular traffic (By similarity).

Gene Ontology (GO) - Molecular Function for RAB36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IBA --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RAB36: view

Phenotypes for RAB36 Gene

genes like me logo Genes that share phenotypes with RAB36: view

Animal Model Products

miRNA for RAB36 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RAB36 Gene

Localization for RAB36 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB36 Gene

Golgi apparatus membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB36 Gene COMPARTMENTS Subcellular localization image for RAB36 gene
Compartment Confidence
golgi apparatus 5
cytosol 2
mitochondrion 2
endosome 1
extracellular 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RAB36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005737 cytoplasm --
GO:0005794 Golgi apparatus TAS 9920784
genes like me logo Genes that share ontologies with RAB36: view

Pathways for RAB36 Gene

SuperPathways for RAB36 Gene

No Data Available

Interacting Proteins for RAB36 Gene

Gene Ontology (GO) - Biological Process for RAB36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport IBA --
GO:0006913 nucleocytoplasmic transport --
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction --
genes like me logo Genes that share ontologies with RAB36: view

No data available for Pathways by source for RAB36 Gene

Transcripts for RAB36 Gene

mRNA/cDNA for RAB36 Gene

(8) Additional mRNA sequences :
(13) REFSEQ mRNAs :
(6) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RAB36 Gene

RAB36, member RAS oncogene family:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAB36

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB36 Gene

No ASD Table

Relevant External Links for RAB36 Gene

GeneLoc Exon Structure for
RAB36
ECgene alternative splicing isoforms for
RAB36

Expression for RAB36 Gene

mRNA expression in normal human tissues for RAB36 Gene

Protein differential expression in normal tissues for RAB36 Gene

This gene is overexpressed in Retina (35.8) and Fetal ovary (25.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB36 Gene

SOURCE GeneReport for Unigene cluster for RAB36 Gene Hs.369557

mRNA Expression by UniProt/SwissProt for RAB36 Gene

O95755-RAB36_HUMAN
Tissue specificity: Ubiquitously present in all tissues examined
genes like me logo Genes that share expressions with RAB36: view

Expression partners for RAB36 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RAB36 Gene

Orthologs for RAB36 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAB36 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RAB36 35
  • 86.89 (n)
  • 87.27 (a)
RAB36 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAB36 35
  • 86.39 (n)
  • 87.07 (a)
RAB36 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rab36 35
  • 85.66 (n)
  • 88.3 (a)
Rab36 16
Rab36 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RAB36 35
  • 99.3 (n)
  • 99.1 (a)
RAB36 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rab36 35
  • 85.79 (n)
  • 88.3 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia RAB36 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAB36 35
  • 70.43 (n)
  • 71.8 (a)
RAB36 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rab36 35
  • 66.28 (n)
  • 66.54 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.15626 35
rab36 35
  • 63.16 (n)
  • 63.42 (a)
rab36 36
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7980 37
  • 52 (a)
RabX5 35
  • 55.17 (n)
  • 49.5 (a)
RabX5 36
  • 39 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006035 35
  • 53.2 (n)
  • 47.76 (a)
worm
(Caenorhabditis elegans)
Secernentea C56E6.2 36
  • 23 (a)
ManyToMany
Y71H2AM.12 36
  • 36 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPT6 36
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToMany
Species with no ortholog for RAB36:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB36 Gene

ENSEMBL:
Gene Tree for RAB36 (if available)
TreeFam:
Gene Tree for RAB36 (if available)

Paralogs for RAB36 Gene

Paralogs for RAB36 Gene

genes like me logo Genes that share paralogs with RAB36: view

Variants for RAB36 Gene

Sequence variations from dbSNP and Humsavar for RAB36 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs713682 -- 23,161,464(+) GATTC(C/T)TGGTT intron-variant
rs737818 -- 23,161,569(+) ACTGG(A/G)GCCTG utr-variant-3-prime, synonymous-codon, reference
rs737819 -- 23,161,632(+) TGGTG(C/T)GGAGA utr-variant-3-prime
rs737820 -- 23,161,683(+) GGCCC(A/G)TGTTC utr-variant-3-prime
rs756633 -- 23,158,366(+) GCCCC(A/T)CGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB36 Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855
dgv4900n71 CNV Gain 21882294
nsv521695 CNV Loss 19592680
esv34158 CNV Loss 18971310

Relevant External Links for RAB36 Gene

HapMap Linkage Disequilibrium report
RAB36

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB36 Gene

Disorders for RAB36 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for RAB36 Gene in MalaCards »

(1) Diseases for RAB36 Gene including...

(1) University of Copenhagen DISEASES for RAB36 Gene

Relevant External Links for RAB36

Genetic Association Database (GAD)
RAB36
genes like me logo Genes that share disorders with RAB36: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for RAB36 Gene

Publications for RAB36 Gene

  1. Cloning and characterization of a novel Rab-family gene, Rab36, within the region at 22q11.2 that is homozygously deleted in malignant rhabdoid tumors. (PMID: 9920784) Mori T. … Inazawa J. (Biochem. Biophys. Res. Commun. 1999) 2 3 4
  2. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 2 3
  3. Isolation of genes from the rhabdoid tumor deletion region in chromosome band 22q11.2. (PMID: 10607907) Zhou J.-Y. … Biegel J.A. (Gene 2000) 3 4
  4. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for RAB36 Gene

Sources for RAB36 Gene

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