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Aliases for RAB36 Gene

Aliases for RAB36 Gene

  • RAB36, Member RAS Oncogene Family 2 3 5

External Ids for RAB36 Gene

Previous GeneCards Identifiers for RAB36 Gene

  • GC22P020186
  • GC22P021812
  • GC22P023487
  • GC22P006455

Summaries for RAB36 Gene

GeneCards Summary for RAB36 Gene

RAB36 (RAB36, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Golgi-to-ER retrograde transport and Vesicle-mediated transport. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB41.

UniProtKB/Swiss-Prot for RAB36 Gene

  • Protein transport. Probably involved in vesicular traffic (By similarity).

Gene Wiki entry for RAB36 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB36 Gene

Genomics for RAB36 Gene

Regulatory Elements for RAB36 Gene

Enhancers for RAB36 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RAB36 on UCSC Golden Path with GeneCards custom track

Promoters for RAB36 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RAB36 on UCSC Golden Path with GeneCards custom track

Genomic Location for RAB36 Gene

23,145,326 bp from pter
23,169,285 bp from pter
23,960 bases
Plus strand

Genomic View for RAB36 Gene

Genes around RAB36 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB36 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB36 Gene

Proteins for RAB36 Gene

  • Protein details for RAB36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras-related protein Rab-36
    Protein Accession:
    Secondary Accessions:
    • Q2M390
    • Q7Z4A9
    • Q9UHP5

    Protein attributes for RAB36 Gene

    333 amino acids
    Molecular mass:
    36322 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RAB36 Gene


neXtProt entry for RAB36 Gene

Proteomics data for RAB36 Gene at MOPED

Post-translational modifications for RAB36 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB36 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RAB36 Gene

Domains & Families for RAB36 Gene

Gene Families for RAB36 Gene

Suggested Antigen Peptide Sequences for RAB36 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Rab family.
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB36: view

Function for RAB36 Gene

Molecular function for RAB36 Gene

GENATLAS Biochemistry:
RAB6,Ras oncogene superfamily member,involved in vesicular trafficking associated with intra-Golgi transport in a region deleted in malignant rhabdoid tumors but not involved in tumorigenesis,potential contributor,like RAB6
UniProtKB/Swiss-Prot Function:
Protein transport. Probably involved in vesicular traffic (By similarity).
genes like me logo Genes that share phenotypes with RAB36: view

Animal Models for RAB36 Gene

MGI Knock Outs for RAB36:

Animal Model Products

miRNA for RAB36 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RAB36 Gene

Localization for RAB36 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB36 Gene

Golgi apparatus membrane; Lipid-anchor.

Subcellular locations from

Jensen Localization Image for RAB36 Gene COMPARTMENTS Subcellular localization image for RAB36 gene
Compartment Confidence
golgi apparatus 5
cytosol 2
mitochondrion 2
endosome 1
extracellular 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RAB36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
genes like me logo Genes that share ontologies with RAB36: view

Pathways & Interactions for RAB36 Gene

genes like me logo Genes that share pathways with RAB36: view

Pathways by source for RAB36 Gene

Interacting Proteins for RAB36 Gene

Gene Ontology (GO) - Biological Process for RAB36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with RAB36: view

No data available for SIGNOR curated interactions for RAB36 Gene

Drugs & Compounds for RAB36 Gene

No Compound Related Data Available

Transcripts for RAB36 Gene

mRNA/cDNA for RAB36 Gene

(13) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RAB36 Gene

RAB36, member RAS oncogene family:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAB36 Gene

No ASD Table

Relevant External Links for RAB36 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RAB36 Gene

mRNA expression in normal human tissues for RAB36 Gene

Protein differential expression in normal tissues from HIPED for RAB36 Gene

This gene is overexpressed in Retina (35.8) and Fetal ovary (25.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB36 Gene

SOURCE GeneReport for Unigene cluster for RAB36 Gene Hs.369557

mRNA Expression by UniProt/SwissProt for RAB36 Gene

Tissue specificity: Ubiquitously present in all tissues examined.
genes like me logo Genes that share expression patterns with RAB36: view

Protein tissue co-expression partners for RAB36 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RAB36 Gene

Orthologs for RAB36 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAB36 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RAB36 35
  • 86.89 (n)
  • 87.27 (a)
RAB36 36
  • 82 (a)
(Canis familiaris)
Mammalia RAB36 35
  • 86.39 (n)
  • 87.07 (a)
RAB36 36
  • 87 (a)
(Mus musculus)
Mammalia Rab36 35
  • 85.66 (n)
  • 88.3 (a)
Rab36 16
Rab36 36
  • 88 (a)
(Pan troglodytes)
Mammalia RAB36 35
  • 99.3 (n)
  • 99.1 (a)
RAB36 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Rab36 35
  • 85.79 (n)
  • 88.3 (a)
(Ornithorhynchus anatinus)
Mammalia RAB36 36
  • 80 (a)
(Gallus gallus)
Aves RAB36 35
  • 70.43 (n)
  • 71.8 (a)
RAB36 36
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rab36 35
  • 66.28 (n)
  • 66.54 (a)
(Danio rerio)
Actinopterygii Dr.15626 35
rab36 35
  • 63.16 (n)
  • 63.42 (a)
rab36 36
  • 61 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7980 37
  • 52 (a)
RabX5 35
  • 55.17 (n)
  • 49.5 (a)
RabX5 36
  • 39 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006035 35
  • 53.2 (n)
  • 47.76 (a)
(Caenorhabditis elegans)
Secernentea C56E6.2 36
  • 23 (a)
Y71H2AM.12 36
  • 36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPT6 36
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
Species with no ortholog for RAB36:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB36 Gene

Gene Tree for RAB36 (if available)
Gene Tree for RAB36 (if available)

Paralogs for RAB36 Gene

Paralogs for RAB36 Gene

genes like me logo Genes that share paralogs with RAB36: view

Variants for RAB36 Gene

Sequence variations from dbSNP and Humsavar for RAB36 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs5759612 - 23,160,983(+) TCGGC(A/G)ATGGA downstream-variant-500B, reference, missense
VAR_034433 -
rs9624038 - 23,161,520(+) CGCCC(A/G)AGACC intron-variant, reference, missense
rs2106109 -- 23,157,487(+) ATCTC(C/T)TGACT intron-variant
rs2106110 -- 23,157,557(+) cctgg(C/T)GACTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB36 Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855
dgv4900n71 CNV Gain 21882294
nsv521695 CNV Loss 19592680
esv34158 CNV Loss 18971310

Variation tolerance for RAB36 Gene

Residual Variation Intolerance Score: 78.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.94; 49.13% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RAB36 Gene

Disorders for RAB36 Gene

Relevant External Links for RAB36

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RAB36 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB36 Gene

Publications for RAB36 Gene

  1. Cloning and characterization of a novel Rab-family gene, Rab36, within the region at 22q11.2 that is homozygously deleted in malignant rhabdoid tumors. (PMID: 9920784) Mori T. … Inazawa J. (Biochem. Biophys. Res. Commun. 1999) 2 3 4 67
  2. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 2 3
  3. RUTBC2 protein, a Rab9A effector and GTPase-activating protein for Rab36. (PMID: 22637480) Nottingham R.M. … Pfeffer S.R. (J. Biol. Chem. 2012) 3
  4. Rab36 regulates the spatial distribution of late endosomes and lysosomes through a similar mechanism to Rab34. (PMID: 19961360) Chen L. … Wang T. (Mol. Membr. Biol. 2010) 3
  5. Pericentrosomal targeting of Rab6 secretory vesicles by Bicaudal-D-related protein 1 (BICDR-1) regulates neuritogenesis. (PMID: 20360680) Schlager M.A. … Hoogenraad C.C. (EMBO J. 2010) 3

Products for RAB36 Gene

Sources for RAB36 Gene