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Aliases for RAB36 Gene

Aliases for RAB36 Gene

  • RAB36, Member RAS Oncogene Family 2 3 5

External Ids for RAB36 Gene

Previous GeneCards Identifiers for RAB36 Gene

  • GC22P020186
  • GC22P021812
  • GC22P023487
  • GC22P006455

Summaries for RAB36 Gene

GeneCards Summary for RAB36 Gene

RAB36 (RAB36, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and Intra-Golgi traffic. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB34.

UniProtKB/Swiss-Prot for RAB36 Gene

  • Protein transport. Probably involved in vesicular traffic (By similarity).

Gene Wiki entry for RAB36 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB36 Gene

Genomics for RAB36 Gene

Regulatory Elements for RAB36 Gene

Enhancers for RAB36 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F023278 1.6 FANTOM5 Ensembl ENCODE 18.2 +135.7 135720 5.8 HDGF ATF1 PKNOX1 CREB3L1 ARID4B YBX1 ZNF48 ZNF2 GLIS2 ZNF143 ZNF70 RAB36 FBXW4P1 RSPH14 IGLV5-52 ENSG00000272779 BCR PIR39869 GC22P023342
GH22F023277 0.5 ENCODE 17.9 +131.8 131763 0.2 NR2F1 RAB36 RSPH14 PIR39869 GC22P023342
GH22F023112 0.8 Ensembl ENCODE 17.8 -31.5 -31455 2.7 ATF1 TBL1XR1 EBF1 ZIC2 ZFHX2 GLIS2 POLR2A ZNF366 PATZ1 ZHX1 RAB36 RSPH14 GNAZ BCR PIR59194 PIR32987 GC22P023108
GH22F023240 0.9 Ensembl ENCODE 16.7 +100.9 100921 12.5 ARID4B ZNF2 BRCA1 ZNF48 GLIS2 ZNF143 ZNF548 FOS ZNF263 SP5 IGLV5-52 FBXW4P1 ENSG00000272779 ZNF70 RAB36 ENSG00000234630 RSPH14 ENSG00000272578 ENSG00000232545 BCR
GH22F023263 0.4 ENCODE 12 +119.2 119171 2.5 HDGF MAFG ZNF384 ZIC2 HDAC8 RAD21 ZBTB40 KAT8 NR2F2 ZFHX2 FBXW4P1 RAB36 RSPH14 PIR39869 GC22P023342
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RAB36 on UCSC Golden Path with GeneCards custom track

Promoters for RAB36 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000292837 74 801 PKNOX1 INSM2 ZNF76 KLF17 ARID4B SIN3A BMI1 ZNF2 GLIS2 EGR1

Genomic Location for RAB36 Gene

Chromosome:
22
Start:
23,145,326 bp from pter
End:
23,169,285 bp from pter
Size:
23,960 bases
Orientation:
Plus strand

Genomic View for RAB36 Gene

Genes around RAB36 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB36 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB36 Gene

Proteins for RAB36 Gene

  • Protein details for RAB36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95755-RAB36_HUMAN
    Recommended name:
    Ras-related protein Rab-36
    Protein Accession:
    O95755
    Secondary Accessions:
    • Q2M390
    • Q7Z4A9
    • Q9UHP5

    Protein attributes for RAB36 Gene

    Size:
    333 amino acids
    Molecular mass:
    36322 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RAB36 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAB36 Gene

Post-translational modifications for RAB36 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RAB36 Gene

Domains & Families for RAB36 Gene

Gene Families for RAB36 Gene

Suggested Antigen Peptide Sequences for RAB36 Gene

Graphical View of Domain Structure for InterPro Entry

O95755

UniProtKB/Swiss-Prot:

RAB36_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB36: view

Function for RAB36 Gene

Molecular function for RAB36 Gene

GENATLAS Biochemistry:
RAB6,Ras oncogene superfamily member,involved in vesicular trafficking associated with intra-Golgi transport in a region deleted in malignant rhabdoid tumors but not involved in tumorigenesis,potential contributor,like RAB6
UniProtKB/Swiss-Prot Function:
Protein transport. Probably involved in vesicular traffic (By similarity).

Gene Ontology (GO) - Molecular Function for RAB36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RAB36: view
genes like me logo Genes that share phenotypes with RAB36: view

Animal Models for RAB36 Gene

MGI Knock Outs for RAB36:

Animal Model Products

miRNA for RAB36 Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RAB36 Gene

Localization for RAB36 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB36 Gene

Golgi apparatus membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB36 Gene COMPARTMENTS Subcellular localization image for RAB36 gene
Compartment Confidence
golgi apparatus 5
cytosol 2
mitochondrion 2
endosome 1
extracellular 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RAB36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005622 intracellular IEA --
GO:0005794 Golgi apparatus IEA,TAS 9920784
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RAB36: view

Pathways & Interactions for RAB36 Gene

genes like me logo Genes that share pathways with RAB36: view

Gene Ontology (GO) - Biological Process for RAB36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with RAB36: view

No data available for SIGNOR curated interactions for RAB36 Gene

Transcripts for RAB36 Gene

mRNA/cDNA for RAB36 Gene

(14) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RAB36 Gene

RAB36, member RAS oncogene family:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB36 Gene

No ASD Table

Relevant External Links for RAB36 Gene

GeneLoc Exon Structure for
RAB36
ECgene alternative splicing isoforms for
RAB36

Expression for RAB36 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RAB36 Gene

Protein differential expression in normal tissues from HIPED for RAB36 Gene

This gene is overexpressed in Retina (35.8) and Fetal ovary (25.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RAB36 Gene



Protein tissue co-expression partners for RAB36 Gene

NURSA nuclear receptor signaling pathways regulating expression of RAB36 Gene:

RAB36

SOURCE GeneReport for Unigene cluster for RAB36 Gene:

Hs.369557

mRNA Expression by UniProt/SwissProt for RAB36 Gene:

O95755-RAB36_HUMAN
Tissue specificity: Ubiquitously present in all tissues examined.
genes like me logo Genes that share expression patterns with RAB36: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RAB36 Gene

Orthologs for RAB36 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAB36 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB36 34 35
  • 99.3 (n)
cow
(Bos Taurus)
Mammalia RAB36 34 35
  • 86.89 (n)
dog
(Canis familiaris)
Mammalia RAB36 34 35
  • 86.39 (n)
rat
(Rattus norvegicus)
Mammalia Rab36 34
  • 85.79 (n)
mouse
(Mus musculus)
Mammalia Rab36 34 16 35
  • 85.66 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RAB36 35
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAB36 34 35
  • 70.43 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia rab36 34
  • 66.28 (n)
zebrafish
(Danio rerio)
Actinopterygii rab36 34 35
  • 63.16 (n)
Dr.15626 34
fruit fly
(Drosophila melanogaster)
Insecta RabX5 34 35
  • 55.17 (n)
CG7980 36
  • 52 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006035 34
  • 53.2 (n)
worm
(Caenorhabditis elegans)
Secernentea Y71H2AM.12 35
  • 36 (a)
ManyToMany
C56E6.2 35
  • 23 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPT6 35
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 45 (a)
OneToMany
Species where no ortholog for RAB36 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB36 Gene

ENSEMBL:
Gene Tree for RAB36 (if available)
TreeFam:
Gene Tree for RAB36 (if available)

Paralogs for RAB36 Gene

Variants for RAB36 Gene

Sequence variations from dbSNP and Humsavar for RAB36 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1004932 -- 23,158,185(+) CCACG(C/G)ACTAC intron-variant
rs10427901 -- 23,168,457(+) AAGCG(A/G)CTCCT intron-variant
rs10775764 -- 23,161,382(+) GGCCT(C/T)GAACA intron-variant
rs111309671 -- 23,152,316(+) GGAAC(A/G)CAGTG intron-variant
rs111384674 -- 23,160,393(+) CCAGC(C/T)CGCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB36 Gene

Variant ID Type Subtype PubMed ID
esv34158 CNV loss 18971310
esv3647392 CNV gain 21293372
esv3647394 CNV loss 21293372
esv3893457 CNV gain 25118596
nsv1061433 CNV gain+loss 25217958
nsv1066891 CNV gain 25217958
nsv521695 CNV loss 19592680
nsv588512 CNV loss 21841781
nsv7350 OTHER inversion 18451855

Variation tolerance for RAB36 Gene

Residual Variation Intolerance Score: 78.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.94; 49.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAB36 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAB36

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB36 Gene

Disorders for RAB36 Gene

Relevant External Links for RAB36

Genetic Association Database (GAD)
RAB36
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAB36

No disorders were found for RAB36 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB36 Gene

Publications for RAB36 Gene

  1. Cloning and characterization of a novel Rab-family gene, Rab36, within the region at 22q11.2 that is homozygously deleted in malignant rhabdoid tumors. (PMID: 9920784) Mori T. … Inazawa J. (Biochem. Biophys. Res. Commun. 1999) 2 3 4 64
  2. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Isolation of genes from the rhabdoid tumor deletion region in chromosome band 22q11.2. (PMID: 10607907) Zhou J.-Y. … Biegel J.A. (Gene 2000) 3 4 64
  5. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 2 3 64

Products for RAB36 Gene

Sources for RAB36 Gene

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