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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RAB36 Gene

protein-coding   GIFtS: 53
GCID: GC22P023487

RAB36, Member RAS Oncogene Family

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
RAB36, Member RAS Oncogene Family1 2
Ras-Related Protein Rab-362
Small GTP-Binding Protein Rab362

External Ids:    HGNC: 97751   Entrez Gene: 96092   Ensembl: ENSG000001002287   OMIM: 6056625   UniProtKB: O957553   

Export aliases for RAB36 gene to outside databases

Previous GC identifers: GC22P020186 GC22P021812 GC22P006455


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RAB36 Gene: 
RAB36 (RAB36, member RAS oncogene family) is a protein-coding gene. Diseases associated with RAB36 include rhabdoid cancer, and rhabdoid tumor. GO annotations related to this gene include GTP binding. An important paralog of this gene is RAB6C.

UniProtKB/Swiss-Prot: RAB36_HUMAN, O95755
Function: Protein transport. Probably involved in vesicular traffic (By similarity)

Gene Wiki entry for RAB36 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NT_011520.12  NC_018933.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RAB36 gene promoter:
         ER-alpha   TBP   Elk-1   AML1a   Egr-1   GCNF   FOXJ2 (long isoform)   GCNF-1   c-Myb   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRAB36 promoter sequence
   Search SABiosciences Chromatin IP Primers for RAB36

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB36


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.22   Ensembl cytogenetic band:  22q11.22   HGNC cytogenetic band: 22q11.22

RAB36 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAB36 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P023487:  view genomic region     (about GC identifiers)

Start:
23,487,513 bp from pter      End:
23,506,537 bp from pter
Size:
19,025 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RAB36_HUMAN, O95755 (See protein sequence)
Recommended Name: Ras-related protein Rab-36  
Size: 333 amino acids; 36322 Da
Subcellular location: Golgi apparatus membrane; Lipid-anchor
Secondary accessions: Q2M390 Q7Z4A9 Q9UHP5
Alternative splicing: 2 isoforms:  O95755-1   O95755-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RAB36: NX_O95755

Explore proteomics data for RAB36 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95755

  • RAB36 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RAB36 Protein Expression
    REFSEQ proteins: NP_004905.2  
    ENSEMBL proteins: 
     ENSP00000263116   ENSP00000343494   ENSP00000397594  

    Human Recombinant Protein Products for RAB36: 
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    Cloud-Clone Corp. Proteins for RAB36 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005622intracellular ----
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0005794Golgi apparatus TAS9920784

    RAB36 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RAB: RAB, member RAS oncogene

    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR003579 Small_GTPase_Rab_type
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry O95755

    ProtoNet protein and cluster: O95755

    5 Blocks protein domains:
    IPB001806 Transforming protein P21 RAS signature
    IPB002041 GTP-binding nuclear protein Ran
    IPB003577 Ras small GTPase
    IPB003578 Ras small GTPase
    IPB006688 ADP-ribosylation factor


    UniProtKB/Swiss-Prot: RAB36_HUMAN, O95755
    Similarity: Belongs to the small GTPase superfamily. Rab family


    RAB36 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RAB36_HUMAN, O95755
    Function: Protein transport. Probably involved in vesicular traffic (By similarity)

         Genatlas biochemistry entry for RAB36:
    RAB6,Ras oncogene superfamily member,involved in vesicular trafficking associated with intra-Golgi transport in a
    region deleted in malignant rhabdoid tumors but not involved in tumorigenesis,potential contributor,like RAB6

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity ----
    GO:0005525GTP binding IEA--
         
    RAB36 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RAB36:
     Decreased DCP1a protein expres 

         1 MGI phenotypic allele for Rab36 (no phenotypes)

    RAB36 for phenotypes           About GeneDecksing

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidRAB36 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RAB36

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for RAB36 (ENSP000002631164) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD1ENSP000003057694STRING: ENSP00000305769
    SMAD4ENSP000003415514STRING: ENSP00000341551
    TGFBR1ENSP000003641334STRING: ENSP00000364133
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process ----
    GO:0006886intracellular protein transport ----
    GO:0006913nucleocytoplasmic transport ----
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction IEA--

    RAB36 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RAB36

    Search CenterWatch for drugs/clinical trials and news about RAB36

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RAB36 gene: 
    NM_004914.2  

    Unigene Cluster for RAB36:

    RAB36, member RAS oncogene family
    Hs.369557  [show with all ESTs]
    Unigene Representative Sequence: AB023061
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263116(uc002zwv.1 uc010gtw.1) ENST00000341989 ENST00000420895

    miRNA
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    Inhib. RNA
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    Additional mRNA sequence: 

    AB023061.1 AF133588.1 AK296052.1 AY336745.1 BC017436.1 BC104989.1 BC104991.1 CR456553.1 

    7 DOTS entries:

    DT.91639279  DT.120677454  DT.120677789  DT.101985575  DT.40271688  DT.91956824  DT.92008610 

    6 AceView cDNA sequences:

    CR456553 NM_004914 AB023061 AF133588 AY336745 BC017436 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RAB36 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGACTGTC
    RAB36 Expression
    About this image


    See RAB36 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RAB36

    SOURCE GeneReport for Unigene cluster: Hs.369557

    UniProtKB/Swiss-Prot: RAB36_HUMAN, O95755
    Tissue specificity: Ubiquitously present in all tissues examined

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB36

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RAB36 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rab361 , 5 RAB36, member RAS oncogene family1, 5 85.66(n)1
    88.3(a)1
      10 (38.49 cM)5
    768771  NM_029781.31  NP_084057.11 
     750370585 
    chicken
    (Gallus gallus)
    Aves RAB361 RAB36, member RAS oncogene family 70.43(n)
    71.8(a)
      416953  XM_415245.3  XP_415245.3 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.156262 Transcribed sequence with moderate similarity to protein more 69.69(n)    BM342307.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG79803
    RabX51
    small monomeric GTPase3
    CG7980-PB1
    52(a)3
    55.17(n)1
    49.5(a)1
      62A103
    382091  NM_139387.21  NP_647644.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YPT106
    YPT526
    Rab family GTP-binding protein that contains the P...
    Rab family GTPase, similar to Ypt51p and Ypt53p an...
    32(a)
    27(a)
    many ↔ many
    many ↔ many
    II(737770-738369)
    XI(465367-466071)


    ENSEMBL Gene Tree for RAB36 (if available)
    TreeFam Gene Tree for RAB36 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RAB36 gene
    RAB6C2  RAB6A2  RAB412  RAB342  RAB6B2  
    18/45 SIMAP similar genes for RAB36 using alignment to 2 protein entries:     RAB36_HUMAN (see all proteins) (see all similar genes):
    RAB34    RAB1A    RAB1B    RAB8B    RAB35    RAB11A
    RAB43    RAB4B    RAB7A    RAB13    RAB10    RAB11B
    RAB15    RAB19    RAB37    RAN    RANP1    DKFZp686J07132

    RAB36 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/525 SNPs in RAB36 are shown (see all 525)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2022003421,2
    Cuntested123501142(+) TTCCTC/TGTGGG 2 L syn11Minor allele frequency- T:0.00EU 1321
    rs681063391,2
    C--23485518(+) AATAA-/ATAG  
            
    ATATA
    1 -- us2k10--------
    rs594785591,2
    C--23485521(+) AAATA-/GATA  
            
    TAATT
    1 -- us2k11Minor allele frequency- GATA:0.00NA 2
    rs1873949561,2
    C--23486258(+) CTGGGC/TGACAG 1 -- us2k10--------
    rs1395948661,2
    C--23486310(+) AAACAG/TCTAAA 1 -- us2k10--------
    rs1919261711,2
    --23486360(+) CAAATC/TCAAAT 1 -- us2k10--------
    rs783409581,2
    C,F--23486453(+) TCTGCT/GTCCCG 1 -- us2k11Minor allele frequency- G:0.21NA 120
    rs2011697571,2
    --23486456(+) GCTTC-/CCGCAGTG 1 -- us2k10--------
    rs1176327991,2
    C--23486457(+) CTTCCA/CGCAGT 1 -- us2k10--------
    rs718737831,2
    C--23486462(+) CGCAG-/TGGA  
      CTCCAA
    TTTCC
    1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RAB36 (23487513 - 23506537 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for RAB36:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv521695CNV Loss19592680
    esv34158CNV Loss18971310
    dgv4900n71CNV Gain21882294
    nsv7350OTHER Inversion18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605662    OMIM disorders: --

    2 diseases for RAB36:    About MalaCards
    rhabdoid cancer    rhabdoid tumor

    1 disease from the University of Copenhagen DISEASES database for RAB36:
    Rhabdoid cancer

    RAB36 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RAB36

    Export disorders for RAB36 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RAB36 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with RAB36)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a novel Rab-family gene, Rab36, within the region at 22q11.2 that is homozygously deleted in malignant rhabdoid tumors. (PubMed id 9920784)1, 2, 3 Mori T.... Inazawa J. (1999)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    4. Isolation of genes from the rhabdoid tumor deletion region in chromosome band 22q11.2. (PubMed id 10607907)1, 2 Zhou J.-Y.... Biegel J.A. (2000)
    5. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 3 Dunham I....O'Brien K.P. (1999)
    6. RUTBC2 protein, a Rab9A effector and GTPase-activating protein for Rab36. (PubMed id 22637480)1 Nottingham R.M....Pfeffer S.R. (2012)
    7. Rab36 regulates the spatial distribution of late endo somes and lysosomes through a similar mechanism to Rab34. (PubMed id 19961360)1 Chen L....Wang T. (2010)
    8. Pericentrosomal targeting of Rab6 secretory vesicles b y Bicaudal-D-related protein 1 (BICDR-1) regulates neuritogenesis. (PubMed id 20360680)1 Schlager M.A....Hoogenraad C.C. (2010)
    9. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PubMed id 17903301)4 Vasan R.S....Benjamin E.J. (2007)
    10. Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity. (PubMed id 16923123)1 Itoh T.... Fukuda M. (2006)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9609 HGNC: 9775 AceView: RAB36 Ensembl:ENSG00000100228 euGenes: HUgn9609
    ECgene: RAB36 H-InvDB: RAB36

    (According to HUGE)
    About This Section
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    About This Section
    NameDescription
    PharmGKB entry for RAB36 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAB36 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
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