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Aliases for RAB35 Gene

Aliases for RAB35 Gene

  • RAB35, Member RAS Oncogene Family 2 3 5
  • GTP-Binding Protein RAY 3 4
  • RAB1C 3 4
  • RAY 3 4
  • Ras-Related Protein Rab-1c (GTP-Binding Protein Ray) 3
  • Ras-Related Protein Rab-35 3
  • Ras-Related Protein Rab-1C 4
  • H-Ray 3

External Ids for RAB35 Gene

Previous GeneCards Identifiers for RAB35 Gene

  • GC12M119405
  • GC12M120315
  • GC12M118944
  • GC12M118995
  • GC12M120532
  • GC12M117542

Summaries for RAB35 Gene

GeneCards Summary for RAB35 Gene

RAB35 (RAB35, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB35 include Hypotrichosis 3 and Myopathy, Myofibrillar, 5. Among its related pathways are Vesicle-mediated transport and RAB geranylgeranylation. GO annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB1A.

UniProtKB/Swiss-Prot for RAB35 Gene

  • The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in the process of endocytosis and is an essential rate-limiting regulator of the fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge. May indirectly regulate neurite outgrowth.

Gene Wiki entry for RAB35 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB35 Gene

Genomics for RAB35 Gene

Regulatory Elements for RAB35 Gene

Enhancers for RAB35 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G120198 1.7 FANTOM5 ENCODE dbSUPER 14.4 -83.0 -82950 4.2 CREB3L1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 ZNF610 RCOR2 GCN1 RAB35 SRSF9 PRKAB1 SPPL3 GC12M120197 RPLP0
GH12G120092 1.2 ENCODE dbSUPER 18.4 +23.4 23402 3.1 PKNOX1 ZNF493 ZFP64 ARID4B GLIS2 KLF7 ZNF202 YY2 REST ZNF623 GCN1 RAB35 RPL31P52 C12orf43 BICDL1 GC12M120095 ENSG00000255575
GH12G120290 1.5 ENCODE dbSUPER 14.4 -174.7 -174728 3.4 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 GCN1 RAB35 SRSF9 SIRT4 PRKAB1 RPL31P52 C12orf43 NME2P1 MSI1 GC12M120294
GH12G120089 1.1 dbSUPER 19.5 +27.0 26989 1.4 HDGF PKNOX1 CREB3L1 ARNT SIN3A DMAP1 FEZF1 ZNF2 ZBTB7B YY1 RAB35 MLEC GC12M120095 ENSG00000255575
GH12G120223 2.1 FANTOM5 Ensembl ENCODE dbSUPER 7.9 -114.1 -114083 16.0 MLX FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC PXN SIRT4 RPLP0 RNU4-2 RNU4-1 PXN-AS1 PLA2G1B GCN1 RAB35 MSI1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RAB35 on UCSC Golden Path with GeneCards custom track

Promoters for RAB35 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000058278 402 2601 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZNF143 ZNF207 KLF13

Genomic Location for RAB35 Gene

Chromosome:
12
Start:
120,095,094 bp from pter
End:
120,117,502 bp from pter
Size:
22,409 bases
Orientation:
Minus strand

Genomic View for RAB35 Gene

Genes around RAB35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB35 Gene

Proteins for RAB35 Gene

  • Protein details for RAB35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15286-RAB35_HUMAN
    Recommended name:
    Ras-related protein Rab-35
    Protein Accession:
    Q15286
    Secondary Accessions:
    • B2R6E0
    • B4E390

    Protein attributes for RAB35 Gene

    Size:
    201 amino acids
    Molecular mass:
    23025 Da
    Quaternary structure:
    • Interacts with DENND1A and DENND1B; in a nucleotide-dependent manner (PubMed:20154091, PubMed:22065758). Interacts with DENND1C; weak interaction which is nucleotide-independent (PubMed:20154091). Interacts (GTP-bound form) with ACAP2 and MICALL1; the interaction is direct and probably recruits ACAP2 and MICALL1 to membranes (PubMed:21951725). Interacts with EHD1; the interaction is indirect through MICALL1 and probably recruits EHD1 to membranes (By similarity).

    Three dimensional structures from OCA and Proteopedia for RAB35 Gene

    Alternative splice isoforms for RAB35 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAB35 Gene

Post-translational modifications for RAB35 Gene

  • AMPylation at Tyr-77 by L.pneumophila DrrA occurs in the switch 2 region and leads to moderate inactivation of the GTPase activity. It appears to prolong the lifetime of the GTP state of RAB1B by restricting access of GTPase effectors to switch 2 and blocking effector-stimulated GTP hydrolysis, thereby rendering RAB35 constitutively active.
  • Phosphocholinated by L.pneumophila AnkX. Both GDP-bound and GTP-bound forms can be phosphocholinated. Phosphocholination inhibits the GEF activity of DENND1A.
  • Ubiquitination at isoforms=178
  • Modification sites at PhosphoSitePlus

Other Protein References for RAB35 Gene

No data available for DME Specific Peptides for RAB35 Gene

Domains & Families for RAB35 Gene

Gene Families for RAB35 Gene

Protein Domains for RAB35 Gene

Graphical View of Domain Structure for InterPro Entry

Q15286

UniProtKB/Swiss-Prot:

RAB35_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB35: view

Function for RAB35 Gene

Molecular function for RAB35 Gene

GENATLAS Biochemistry:
RAB35,RAS oncogene superfamily member 35,ubiquitously expressed
UniProtKB/Swiss-Prot EnzymeRegulation:
Rab activation is generally mediated by a guanine exchange factor (GEF), while inactivation through hydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP) (PubMed:20154091). That Rab is activated by the guanine exchange factors DENND1A, DENND1B and DENND1C (PubMed:20154091).
UniProtKB/Swiss-Prot Function:
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in the process of endocytosis and is an essential rate-limiting regulator of the fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge. May indirectly regulate neurite outgrowth.

Gene Ontology (GO) - Molecular Function for RAB35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IDA,TAS 17562788
GO:0005515 protein binding IPI 17562788
GO:0005525 GTP binding IDA,IEA 20937701
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding IDA 16950109
GO:0019003 GDP binding IDA 20937701
genes like me logo Genes that share ontologies with RAB35: view
genes like me logo Genes that share phenotypes with RAB35: view

Animal Models for RAB35 Gene

MGI Knock Outs for RAB35:

Animal Model Products

CRISPR Products

miRNA for RAB35 Gene

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RAB35 Gene

Localization for RAB35 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB35 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Membrane, clathrin-coated pit. Cytoplasmic vesicle, clathrin-coated vesicle. Endosome. Melanosome. Note=Present on sorting endosomes and recycling endosome tubules (PubMed:16950109). Tends to be enriched in PIP2-positive cell membrane domains (PubMed:16950109). During mitosis, associated with the plasma membrane and present at the ingressing furrow during early cytokinesis as well as at the intercellular bridge later during cytokinesis (PubMed:16950109). Identified in stage I to stage IV melanosomes (PubMed:17081065). {ECO:0000269 PubMed:16950109, ECO:0000269 PubMed:17081065}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB35 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 5
endosome 5
mitochondrion 3
cytoskeleton 1
nucleus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for RAB35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005739 mitochondrion IEA --
GO:0005768 endosome IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA,IDA 16950109
genes like me logo Genes that share ontologies with RAB35: view

Pathways & Interactions for RAB35 Gene

genes like me logo Genes that share pathways with RAB35: view

Pathways by source for RAB35 Gene

1 KEGG pathway for RAB35 Gene

Gene Ontology (GO) - Biological Process for RAB35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000910 cytokinesis IMP 16950109
GO:0006810 transport IEA --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0008104 protein localization IMP 16950109
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with RAB35: view

No data available for SIGNOR curated interactions for RAB35 Gene

Drugs & Compounds for RAB35 Gene

No Compound Related Data Available

Transcripts for RAB35 Gene

mRNA/cDNA for RAB35 Gene

Unigene Clusters for RAB35 Gene

RAB35, member RAS oncogene family:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB35 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c
SP1: - -
SP2: - - -
SP3: - - - -
SP4: -
SP5: - -

Relevant External Links for RAB35 Gene

GeneLoc Exon Structure for
RAB35
ECgene alternative splicing isoforms for
RAB35

Expression for RAB35 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAB35 Gene

Protein differential expression in normal tissues from HIPED for RAB35 Gene

This gene is overexpressed in Brain (6.3) and Uterus (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RAB35 Gene



Protein tissue co-expression partners for RAB35 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RAB35 Gene:

RAB35

SOURCE GeneReport for Unigene cluster for RAB35 Gene:

Hs.524788

Evidence on tissue expression from TISSUES for RAB35 Gene

  • Nervous system(4.8)
  • Muscle(4.2)
genes like me logo Genes that share expression patterns with RAB35: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAB35 Gene

Orthologs for RAB35 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAB35 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB35 34 35
  • 99.83 (n)
dog
(Canis familiaris)
Mammalia RAB35 34 35
  • 94.03 (n)
mouse
(Mus musculus)
Mammalia Rab35 34 16 35
  • 93.86 (n)
rat
(Rattus norvegicus)
Mammalia Rab35 34
  • 93.86 (n)
cow
(Bos Taurus)
Mammalia RAB35 34 35
  • 93.2 (n)
oppossum
(Monodelphis domestica)
Mammalia RAB35 35
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAB35 34 35
  • 84.74 (n)
lizard
(Anolis carolinensis)
Reptilia RAB35 35
  • 100 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rab35 34
  • 83.25 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16236 34
zebrafish
(Danio rerio)
Actinopterygii RAB35 (3 of 3) 35
  • 89 (a)
OneToMany
rab35b 34 35
  • 80.93 (n)
BX571714.2 35
  • 69 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003028 34
  • 69.98 (n)
fruit fly
(Drosophila melanogaster)
Insecta Rab35 34 35
  • 68.52 (n)
CG9575 36
  • 66 (a)
CG2885 36
  • 44 (a)
worm
(Caenorhabditis elegans)
Secernentea rab-35 34 35
  • 64.16 (n)
4R79.2 36
  • 39 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC4 35
  • 43 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7112 35
  • 88 (a)
OneToOne
Species where no ortholog for RAB35 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB35 Gene

ENSEMBL:
Gene Tree for RAB35 (if available)
TreeFam:
Gene Tree for RAB35 (if available)

Paralogs for RAB35 Gene

Paralogs for RAB35 Gene

genes like me logo Genes that share paralogs with RAB35: view

Variants for RAB35 Gene

Sequence variations from dbSNP and Humsavar for RAB35 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000121048 -- 120,094,819(+) GCAAA(A/G)GCTTC downstream-variant-500B
rs1000329592 -- 120,100,004(+) CGCAG(A/G)GACCT intron-variant
rs1000473461 -- 120,105,259(+) GATAC(C/G)CAACC intron-variant
rs1000527192 -- 120,104,923(+) GCCAC(A/C)GTGCC intron-variant
rs1000692820 -- 120,116,818(+) GCCGC(C/G)GCTAC upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for RAB35 Gene

Variant ID Type Subtype PubMed ID
nsv519657 CNV loss 19592680
nsv560433 CNV loss 21841781
nsv560434 CNV loss 21841781
nsv952492 CNV deletion 24416366
nsv952493 CNV deletion 24416366

Variation tolerance for RAB35 Gene

Residual Variation Intolerance Score: 49.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.93; 59.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAB35 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAB35

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB35 Gene

Disorders for RAB35 Gene

MalaCards: The human disease database

(3) MalaCards diseases for RAB35 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hypotrichosis 3
  • htss2
myopathy, myofibrillar, 5
  • myofibrillar myopathy 5
charcot-marie-tooth disease, axonal, type 2l
  • charcot-marie-tooth disease axonal type 2l
- elite association - COSMIC cancer census association via MalaCards
Search RAB35 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RAB35

Genetic Association Database (GAD)
RAB35
Human Genome Epidemiology (HuGE) Navigator
RAB35
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAB35
genes like me logo Genes that share disorders with RAB35: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RAB35 Gene

Publications for RAB35 Gene

  1. MICAL-L1 is a tubular endosomal membrane hub that connects Rab35 and Arf6 with Rab8a. (PMID: 21951725) Rahajeng J. … Caplan S. (Traffic 2012) 3 4 64
  2. Insights regarding guanine nucleotide exchange from the structure of a DENN-domain protein complexed with its Rab GTPase substrate. (PMID: 22065758) Wu X. … Reinisch K.M. (Proc. Natl. Acad. Sci. U.S.A. 2011) 3 4 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  5. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 3 4 64

Products for RAB35 Gene

Sources for RAB35 Gene

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