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Aliases for RAB35 Gene

Aliases for RAB35 Gene

  • RAB35, Member RAS Oncogene Family 2 3
  • GTP-Binding Protein RAY 3 4
  • RAB1C 3 4
  • RAY 3 4
  • Ras-Related Protein Rab-1c (GTP-Binding Protein Ray) 3
  • Ras-Related Protein Rab-35 3
  • Ras-Related Protein Rab-1C 4
  • H-Ray 3

External Ids for RAB35 Gene

Previous GeneCards Identifiers for RAB35 Gene

  • GC12M119405
  • GC12M120315
  • GC12M118944
  • GC12M118995
  • GC12M120532
  • GC12M117542

Summaries for RAB35 Gene

GeneCards Summary for RAB35 Gene

RAB35 (RAB35, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Cytoskeletal Signaling. GO annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB33A.

UniProtKB/Swiss-Prot for RAB35 Gene

  • The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in the process of endocytosis and is an essential rate-limiting regulator of the fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge. May indirectly regulate neurite outgrowth.

Gene Wiki entry for RAB35 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB35 Gene

Genomics for RAB35 Gene

Regulatory Elements for RAB35 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RAB35 Gene

Start:
120,095,095 bp from pter
End:
120,117,502 bp from pter
Size:
22,408 bases
Orientation:
Minus strand

Genomic View for RAB35 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAB35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB35 Gene

Proteins for RAB35 Gene

  • Protein details for RAB35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15286-RAB35_HUMAN
    Recommended name:
    Ras-related protein Rab-35
    Protein Accession:
    Q15286
    Secondary Accessions:
    • B2R6E0
    • B4E390

    Protein attributes for RAB35 Gene

    Size:
    201 amino acids
    Molecular mass:
    23025 Da
    Quaternary structure:
    • Interacts with DENND1A and DENND1B; in a nucleotide-dependent manner. Interacts with DENND1C; weak interaction which is nucleotide-independent. Interacts (GTP-bound form) with ACAP2 and MICALL1; the interaction is direct and probably recruits ACAP2 and MICALL1 to membranes. Interacts with EHD1; the interaction is indirect through MICALL1 and probably recruits EHD1 to membranes.

    Three dimensional structures from OCA and Proteopedia for RAB35 Gene

    Alternative splice isoforms for RAB35 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAB35 Gene

Proteomics data for RAB35 Gene at MOPED

Post-translational modifications for RAB35 Gene

  • AMPylation at Tyr-77 by L.pneumophila DrrA occurs in the switch 2 region and leads to moderate inactivation of the GTPase activity. It appears to prolong the lifetime of the GTP state of RAB1B by restricting access of GTPase effectors to switch 2 and blocking effector-stimulated GTP hydrolysis, thereby rendering RAB35 constitutively active.
  • Phosphocholinated by L.pneumophila AnkX. Both GDP-bound and GTP-bound forms can be phosphocholinated. Phosphocholination inhibits the GEF activity of DENND1A
  • Ubiquitination at Lys58 and Lys178
  • Modification sites at PhosphoSitePlus

Other Protein References for RAB35 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RAB35 (Rab35)

No data available for DME Specific Peptides for RAB35 Gene

Domains for RAB35 Gene

Gene Families for RAB35 Gene

HGNC:
  • RAB :RAB, member RAS oncogene

Graphical View of Domain Structure for InterPro Entry

Q15286

UniProtKB/Swiss-Prot:

RAB35_HUMAN :
  • Q15286
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB35: view

Function for RAB35 Gene

Molecular function for RAB35 Gene

GENATLAS Biochemistry: RAB35,RAS oncogene superfamily member 35,ubiquitously expressed
UniProtKB/Swiss-Prot EnzymeRegulation: Rab activation is generally mediated by a guanine exchange factor (GEF), while inactivation through hydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP). That Rab is activated by the guanine exchange factors DENND1A, DENND1B and DENND1C.
UniProtKB/Swiss-Prot Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in the process of endocytosis and is an essential rate-limiting regulator of the fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge. May indirectly regulate neurite outgrowth.

Gene Ontology (GO) - Molecular Function for RAB35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IDA 17562788
GO:0005515 protein binding IPI 17562788
GO:0005525 GTP binding IDA 20937701
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding IDA 16950109
GO:0019003 GDP binding IDA 20937701
genes like me logo Genes that share ontologies with RAB35: view
genes like me logo Genes that share phenotypes with RAB35: view

Animal Model Products

CRISPR Products

miRNA for RAB35 Gene

miRTarBase miRNAs that target RAB35

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAB35

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RAB35 Gene

Localization for RAB35 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB35 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Membrane, clathrin-coated pit. Cytoplasmic vesicle, clathrin-coated vesicle. Endosome. Melanosome. Note=Present on sorting endosomes and recycling endosome tubules. Tends to be enriched in PIP2-positive cell membrane domains. During mitosis, associated with the plasma membrane and present at the ingressing furrow during early cytokinesis as well as at the intercellular bridge later during cytokinesis. Identified in stage I to stage IV melanosomes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB35 Gene COMPARTMENTS Subcellular localization image for RAB35 gene
Compartment Confidence
endosome 5
extracellular 5
plasma membrane 5
cytosol 3
mitochondrion 2
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RAB35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 NOT Golgi membrane IBA --
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005737 cytoplasm --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with RAB35: view

Pathways for RAB35 Gene

SuperPathways for RAB35 Gene

Superpath Contained pathways
1 Cytoskeletal Signaling
genes like me logo Genes that share pathways with RAB35: view

Pathways by source for RAB35 Gene

1 Cell Signaling Technology pathway for RAB35 Gene

Gene Ontology (GO) - Biological Process for RAB35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000910 cytokinesis IMP 16950109
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport IBA --
GO:0006888 ER to Golgi vesicle-mediated transport IBA --
GO:0006913 nucleocytoplasmic transport --
genes like me logo Genes that share ontologies with RAB35: view

Transcripts for RAB35 Gene

mRNA/cDNA for RAB35 Gene

(11) Selected AceView cDNA sequences:
(13) Additional mRNA sequences :
(3) REFSEQ mRNAs :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RAB35 Gene

RAB35, member RAS oncogene family:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAB35

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB35 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c
SP1: - -
SP2: - - -
SP3: - - - -
SP4: -
SP5: - -

Relevant External Links for RAB35 Gene

GeneLoc Exon Structure for
RAB35
ECgene alternative splicing isoforms for
RAB35

Expression for RAB35 Gene

mRNA expression in normal human tissues for RAB35 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB35 Gene

SOURCE GeneReport for Unigene cluster for RAB35 Gene Hs.524788

genes like me logo Genes that share expressions with RAB35: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RAB35 Gene

Orthologs for RAB35 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAB35 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB35 35
  • 99.83 (n)
  • 100 (a)
RAB35 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RAB35 35
  • 93.2 (n)
  • 100 (a)
RAB35 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAB35 35
  • 94.03 (n)
  • 99.5 (a)
RAB35 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rab35 35
  • 93.86 (n)
  • 100 (a)
Rab35 16
Rab35 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAB35 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rab35 35
  • 93.86 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves RAB35 35
  • 84.74 (n)
  • 98.51 (a)
RAB35 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAB35 36
  • 100 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.16236 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rab35 35
  • 83.25 (n)
  • 98.01 (a)
zebrafish
(Danio rerio)
Actinopterygii BX571714.2 36
  • 69 (a)
OneToMany
RAB35 (3 of 3) 36
  • 89 (a)
OneToMany
rab35b 35
  • 80.93 (n)
  • 92.54 (a)
rab35b 36
  • 93 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003028 35
  • 69.98 (n)
  • 77.11 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rab35 35
  • 68.52 (n)
  • 73.74 (a)
Rab35 36
  • 72 (a)
OneToOne
CG9575 37
  • 66 (a)
CG2885 37
  • 44 (a)
worm
(Caenorhabditis elegans)
Secernentea rab-35 35
  • 64.16 (n)
  • 76.3 (a)
rab-35 36
  • 67 (a)
OneToOne
4R79.2 37
  • 39 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC4 36
  • 43 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7112 36
  • 88 (a)
OneToOne
Species with no ortholog for RAB35:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB35 Gene

ENSEMBL:
Gene Tree for RAB35 (if available)
TreeFam:
Gene Tree for RAB35 (if available)

Paralogs for RAB35 Gene

Paralogs for RAB35 Gene

genes like me logo Genes that share paralogs with RAB35: view

Variants for RAB35 Gene

Sequence variations from dbSNP and Humsavar for RAB35 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1052093 -- 120,095,195(-) CAAAC(A/C)CCACT utr-variant-3-prime
rs1054631 -- 120,096,667(-) CCGTT(C/G)TCCTG utr-variant-3-prime
rs1057686 -- 120,095,892(-) GAGTT(C/T)AACAC utr-variant-3-prime
rs2239199 -- 120,098,767(+) GAAGG(C/T)GGCCA intron-variant
rs2239200 -- 120,100,847(+) TGGCA(C/T)GGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB35 Gene

Variant ID Type Subtype PubMed ID
nsv899555 CNV Loss 21882294
nsv519657 CNV Loss 19592680

Relevant External Links for RAB35 Gene

HapMap Linkage Disequilibrium report
RAB35

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB35 Gene

Disorders for RAB35 Gene

Relevant External Links for RAB35

Genetic Association Database (GAD)
RAB35
Human Genome Epidemiology (HuGE) Navigator
RAB35
genes like me logo Genes that share disorders with RAB35: view

No data available for UniProtKB/Swiss-Prot for RAB35 Gene

Publications for RAB35 Gene

  1. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 3 4
  2. Rab35 regulates an endocytic recycling pathway essential for the terminal steps of cytokinesis. (PMID: 16950109) Kouranti I. … Echard A. (Curr. Biol. 2006) 3 4
  3. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PMID: 17081065) Chi A. … Hunt D.F. (J. Proteome Res. 2006) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48

Products for RAB35 Gene

Sources for RAB35 Gene

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