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RAB35 Gene

protein-coding   GIFtS: 63
GCID: GC12M120532

RAB35, Member RAS Oncogene Family

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RAB35, Member RAS Oncogene Family1 2     H-ray2
RAB1C2 3     Ras-Related Protein Rab-1c (GTP-Binding Protein Ray)2
RAY2 3     Ras-Related Protein Rab-352
GTP-Binding Protein RAY2 3     Ras-Related Protein Rab-1C3

External Ids:    HGNC: 97741   Entrez Gene: 110212   Ensembl: ENSG000001117377   OMIM: 6041995   UniProtKB: Q152863   

Export aliases for RAB35 gene to outside databases

Previous GC identifers: GC12M119405 GC12M120060 GC12M120315 GC12M118944 GC12M118995 GC12M117542


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RAB35 Gene:
RAB35 (RAB35, member RAS oncogene family) is a protein-coding gene. GO annotations related to this gene include GDP binding and GTP binding. An important paralog of this gene is RAB33B.

UniProtKB/Swiss-Prot: RAB35_HUMAN, Q15286
Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of
transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active
GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible
for vesicle formation, movement, tethering and fusion. That Rab is involved in the process of endocytosis and is
an essential rate-limiting regulator of the fast recycling pathway back to the plasma membrane. During
cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and
abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the
intercellular bridge. May indirectly regulate neurite outgrowth

Gene Wiki entry for RAB35 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the RAB35 gene promoter:
         NF-1/L   NF-1   p53   GATA-2   c-Ets-1   CREB   POU2F1   POU2F1a   deltaCREB   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): RAB35 promoter sequence
   Search Chromatin IP Primers for RAB35

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RAB35


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31   Ensembl cytogenetic band:  12q24.23   HGNC cytogenetic band: 12q24

RAB35 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAB35 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M120532:  view genomic region     (about GC identifiers)

Start:
120,532,899 bp from pter      End:
120,555,306 bp from pter
Size:
22,408 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RAB35_HUMAN, Q15286 (See protein sequence)
Recommended Name: Ras-related protein Rab-35  
Size: 201 amino acids; 23025 Da
Subunit: Interacts with DENND1A and DENND1B; in a nucleotide-dependent manner. Interacts with DENND1C; weak
interaction which is nucleotide-independent. Interacts (GTP-bound form) with ACAP2 and MICALL1; the interaction
is direct and probably recruits ACAP2 and MICALL1 to membranes. Interacts with EHD1; the interaction is indirect
through MICALL1 and probably recruits EHD1 to membranes
1 PDB 3D structure from and Proteopedia for RAB35:
3TW8 (3D)    
Secondary accessions: B2R6E0 B4E390
Alternative splicing: 2 isoforms:  Q15286-1   Q15286-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RAB35: NX_Q15286

Explore proteomics data for RAB35 at MOPED

Post-translational modifications: 

  • AMPylation at Tyr-77 by L.pneumophila DrrA occurs in the switch 2 region and leads to moderate inactivation of the
    GTPase activity. It appears to prolong the lifetime of the GTP state of RAB1B by restricting access of GTPase
    effectors to switch 2 and blocking effector-stimulated GTP hydrolysis, thereby rendering RAB35 constitutively
    active1
  • Phosphocholinated by L.pneumophila AnkX. Both GDP-bound and GTP-bound forms can be phosphocholinated.
    Phosphocholination inhibits the GEF activity of DENND1A1
  • Ubiquitination2 at Lys58, Lys178
  • Modification sites at PhosphoSitePlus

  • See RAB35 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001161078.1  NP_006852.1  

    ENSEMBL proteins: 
     ENSP00000229340   ENSP00000442555   ENSP00000441883   ENSP00000443994   ENSP00000399317  

    RAB35 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for RAB35

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RAB: RAB, member RAS oncogene

    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR003579 Small_GTPase_Rab_type
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q15286

    ProtoNet protein and cluster: Q15286

    1 Blocks protein domain: IPB001806 Transforming protein P21 RAS signature

    UniProtKB/Swiss-Prot: RAB35_HUMAN, Q15286
    Similarity: Belongs to the small GTPase superfamily. Rab family


    Find genes that share domains with RAB35           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RAB35_HUMAN, Q15286
    Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of
    transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active
    GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible
    for vesicle formation, movement, tethering and fusion. That Rab is involved in the process of endocytosis and is
    an essential rate-limiting regulator of the fast recycling pathway back to the plasma membrane. During
    cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and
    abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the
    intercellular bridge. May indirectly regulate neurite outgrowth
    Enzyme regulation: Rab activation is generally mediated by a guanine exchange factor (GEF), while inactivation
    through hydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP). That Rab is activated by the
    guanine exchange factors DENND1A, DENND1B and DENND1C

         Genatlas biochemistry entry for RAB35:
    RAB35,RAS oncogene superfamily member 35,ubiquitously expressed

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity TAS7811277
    GO:0005515protein binding IPI--
    GO:0005525GTP binding IDA--
    GO:0005546phosphatidylinositol-4,5-bisphosphate binding IDA16950109
    GO:0019003GDP binding IDA--
         
    Find genes that share ontologies with RAB35           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for RAB35:
     Decreased G3BP1 protein expres  Decreased cilium length  Decreased cilium length after  

         1 MGI phenotypic allele for Rab35 (no phenotypes)

    Find genes that share phenotypes with RAB35           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RAB35
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    miRNA
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    Block miRNA regulation of human, mouse, rat RAB35 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RAB35 (see all 45):
    hsa-miR-579 hsa-miR-4328 hsa-let-7a-2* hsa-miR-219-5p hsa-miR-508-3p hsa-miR-1184 hsa-miR-23a hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidRAB35 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RAB35

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    Sino Biological Human cDNA Clone for RAB35
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RAB35_HUMAN, Q15286: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Membrane, clathrin-coated pit.
    Cytoplasmic vesicle, clathrin-coated vesicle. Endosome. Melanosome. Note=Present on sorting endosomes and
    recycling endosome tubules. Tends to be enriched in PIP2-positive cell membrane domains. During mitosis,
    associated with the plasma membrane and present at the ingressing furrow during early cytokinesis as well as at
    the intercellular bridge later during cytokinesis. Identified in stage I to stage IV melanosomes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    extracellular5
    plasma membrane5
    cytosol3
    mitochondrion2
    cytoskeleton1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion IEA--
    GO:0005886plasma membrane IDA16950109

    Find genes that share ontologies with RAB35           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RAB35 About    
    See pathways by source

    SuperPathContained pathways About
    1Cytoskeletal Signaling
    Cytoskeletal Signaling


    Find genes that share SuperPaths with RAB35           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for RAB35
        Cytoskeletal Signaling



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RAB35
    Interactions:

        Search GeneGlobe Interaction Network for RAB35

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    Selected Interacting proteins for RAB35 (Q152861, 2, 3 ENSP000002293404) via UniProtKB, MINT, STRING, and/or I2D (see all 35)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACTBP607092, 3, ENSP000003499604MINT-7012070 I2D: score=1 STRING: ENSP00000349960
    CBR3O758282, 3MINT-64229 I2D: score=5 
    C2orf44Q9H6R72, 3MINT-64233 I2D: score=4 
    CDC42P609532, 3, ENSP000003144584MINT-7012095 I2D: score=1 STRING: ENSP00000314458
    RAC1P630002, 3, ENSP000003484614MINT-7012081 I2D: score=1 STRING: ENSP00000348461
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000910cytokinesis IMP16950109
    GO:0006184GTP catabolic process TAS7811277
    GO:0006886intracellular protein transport ----
    GO:0006913nucleocytoplasmic transport ----
    GO:0007165signal transduction ----

    Find genes that share ontologies with RAB35           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RAB35



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RAB35 gene (2 alternative transcripts): 
    NM_001167606.1  NM_006861.6  

    Unigene Cluster for RAB35:

    RAB35, member RAS oncogene family
    Hs.524788  [show with all ESTs]
    Unigene Representative Sequence: NM_006861
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000229340(uc001txm.2 uc010szh.2 uc009zww.2) ENST00000544304
    ENST00000534951 ENST00000538903 ENST00000543364 ENST00000540803 ENST00000432953

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    Selected qRT-PCR Assays for microRNAs that regulate RAB35 (see all 45):
    hsa-miR-579 hsa-miR-4328 hsa-let-7a-2* hsa-miR-219-5p hsa-miR-508-3p hsa-miR-1184 hsa-miR-23a hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidRAB35 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF498960.1 AK001309.2 AK125543.1 AK298391.1 AK300127.1 AK304620.1 AK312538.1 BC015931.2 
    BC017753.1 BT020024.1 CR536486.1 CR541683.1 X79781.1 

    13 DOTS entries:

    DT.309459  DT.91960376  DT.75159901  DT.100782112  DT.100027022  DT.100711889  DT.100757062  DT.100782110 
    DT.121137122  DT.121137165  DT.91751452  DT.95278290  DT.97774884 

    11 AceView cDNA sequences:

    AK001309 BC017753 CR622981 CR623183 NM_006861 CR541683 CR536486 AF498960 
    AK125543 BC015931 X79781 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RAB35    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c
    SP1:                          -           -                           
    SP2:        -                 -           -                           
    SP3:        -                 -           -     -                     
    SP4:                                      -                           
    SP5:        -                 -                                       


    ECgene alternative splicing isoforms for RAB35

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RAB35 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATGGGGGTT
    RAB35 Expression
    About this image

    RAB35 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RAB35 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.524788
        Custom PCR Arrays for RAB35
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB35

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RAB35 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rab351 , 5 RAB35, member RAS oncogene family1, 5 93.86(n)1
    100(a)1
      5 (56.10 cM)5
    774071  NM_198163.11  NP_937806.11 
     1156319295 
    chicken
    (Gallus gallus)
    Aves RAB351 RAB35, member RAS oncogene family 84.74(n)
    98.51(a)
      416983  NM_001030669.2  NP_001025840.1 
    lizard
    (Anolis carolinensis)
    Reptilia RAB356
    RAB35, member RAS oncogene family
    100(a)
    1 ↔ 1
    GL343338.1(394128-411754)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.162362 Xenopus laevis, Similar to RAB35, member RAS oncogene more 78.41(n)    BC041759.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BQ450111.12   -- 83.12(n)    BQ450111.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG95753
    Rab351
    RAB small monomeric GTPase3
    Rab351
    66(a)
    (best of 2)3
    68.52(n)1
    73.74(a)1
      19B33
    330141  NM_134529.41  NP_608373.11 
    worm
    (Caenorhabditis elegans)
    Secernentea 4R79.23
    rab-351
    Ras family3
    rab-351
    39(a)3
    64.16(n)1
    76.3(a)1
      IV(17480552-17483486)3
    1765601  NM_067053.31  NP_499454.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SEC46
    Rab family GTPase essential for vesicle-mediated e...
    43(a)
    1 → many
    VI(130334-130981) YFL005W


    ENSEMBL Gene Tree for RAB35 (if available)
    TreeFam Gene Tree for RAB35 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RAB35 gene
    RAB33B2  RAB33A2  RAB182  
    Selected SIMAP similar genes for RAB35 using alignment to 4 protein entries:     RAB35_HUMAN (see all proteins) (see all similar genes):
    RAB8B    RAB3A    RAB43    RAB8A    RAB10    RAB3D
    DKFZp686J07132    RAB36    RAB6A'    RAB15    RAB3B    RAB13
    RAB19    RAB5B    RAB30    RAB2B    RAB11B    RAB27B

    Find genes that share paralogs with RAB35           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RAB35 (see all 532)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1915579601,2
    C--120532858(+) GGCCAA/CTCAGC 2 -- int10--------
    rs1838953551,2
    --120532868(+) CACATC/GTCTGG 2 -- int10--------
    rs1867642291,2
    --120532974(+) AAATAC/TTCCTA 2 -- ut310--------
    rs10520931,2
    C,H--120532999(-) CAAACA/CCCACT 2 -- ut316Minor allele frequency- C:0.00MN EA NS NA 478
    rs780130331,2
    C,F--120533002(+) GGTGTT/GTGTTT 2 -- ut313Minor allele frequency- G:0.12WA CSA 122
    rs1912332801,2
    --120533042(+) ACGTCA/GGTCCA 2 -- ut310--------
    rs1386941391,2
    --120533275(+) GCATG-/CCCCCC 2 -- ut310--------
    rs1855769781,2
    --120533280(+) CCCCCC/TGCCCA 2 -- ut310--------
    rs1904845571,2
    C--120533382(+) GCCCCC/TGCCCC 2 -- ut310--------
    rs10576861,2
    C,F,O,A,H--120533696(-) GAGTTT/CAACAC 2 -- ut31 ese335Minor allele frequency- C:0.27MN EA NA NS WA CSA 3514

    HapMap Linkage Disequilibrium report for RAB35 (120532899 - 120555306 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RAB35:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv899555CNV Loss21882294
    nsv519657CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RAB35
    DNA2.0 Custom Variant and Variant Library Synthesis for RAB35

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604199    OMIM disorders: --


    Find genes that share disorders with RAB35           About GenesLikeMe

    Genetic Association Database (GAD): RAB35
    Human Genome Epidemiology (HuGE) Navigator: RAB35 (2 documents)

    Export disorders for RAB35 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RAB35 gene, integrated from 10 sources (see all 46):
    (articles sorted by number of sources associating them with RAB35)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Insights regarding guanine nucleotide exchange from the structure of a DENN-domain protein complexed with its Rab GTPase substrate. (PubMed id 22065758)1, 2 Wu X....Reinisch K.M. (Proc. Natl. Acad. Sci. U.S.A. 2011)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Rab35 regulates an endocytic recycling pathway essential for the terminal steps of cytokinesis. (PubMed id 16950109)1, 2 Kouranti I.... Echard A. (Curr. Biol. 2006)
    5. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (J. Proteome Res. 2006)
    6. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)1, 2 Scherer S.E.... Gibbs R.A. (Nature 2006)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Molecular cloning of two small GTP-binding proteins from human skeletal muscle. (PubMed id 7811277)1, 2 Zhu A.X.... Flier J.S. (Biochem. Biophys. Res. Commun. 1994)
    10. A Small Ras-like protein Ray/Rab1c modulates the p53-regulating activity of PRPK. (PubMed id 16600182)1, 9 Abe Y....Kito K. (Biochem. Biophys. Res. Commun. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11021 HGNC: 9774 AceView: RAB35 Ensembl:ENSG00000111737 euGenes: HUgn11021
    ECgene: RAB35 H-InvDB: RAB35

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RAB35 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAB35 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RAB35 gene:
    Search GeneIP for patents involving RAB35

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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