Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RAB34 Gene

protein-coding GIFtS: 54
GCID: GC17M027041

RAB34, member RAS oncogene family

Explore 6 diseases affiliated with
RAB34 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
RAB34, Member RAS Oncogene Family¹ ²		Ras-Related Protein Rah² ³
RAH¹ ² ³ ⁵		Ras-Related Protein Rab-34²
RAB39¹ ² ³		NARR³
Ras-Related Protein Rab-39² ³		Nine Amino-Acid Residue-Repeats³

External Ids:	HGNC: 16519¹	Entrez Gene: 83871²	Ensembl: ENSG00000109113⁷	OMIM: 610917⁵	UniProtKB: P0DI83³
	UniProtKB: Q9BZG1³

ORGUL members:
	NONCODE:n407078

Export aliases for RAB34 gene to outside databases

Previous GC identifers: GC17M026887 GC17M028941 GC17M027186 GC17M024065 GC17M023250

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RAB34:

This gene encodes a protein belonging to the RAB family of proteins, which are small GTPases involved in protein

transport. This family member is a Golgi-bound member of the secretory pathway that is involved in the repositioning

of lysosomes and the activation of macropinocytosis. Alternative splicing of this gene results in multiple transcript

variants. This gene overlaps and shares exon structure with the nine-amino acid residue-repeats (NARR) gene, which

encodes a functionally distinct nucleolar protein from a different reading frame. (provided by RefSeq, Jan 2012)

UniProtKB/Swiss-Prot: RAB34_HUMAN, Q9BZG1

Function: Protein transport. Involved in the redistribution of lysosomes to the peri-Golgi region (By similarity).

Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role

in the fusion of phagosomes with lysosomes

Gene Wiki entry for RAB34

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010799.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RAB34 gene promoter:
AP-1 ATF-2 c-Jun Tal-1beta
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RAB34 promoter sequence

Search SABiosciences Chromatin IP Primers for RAB34

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB34

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2 Ensembl cytogenetic band: 17q11.2 HGNC cytogenetic band: 17q11.2

RAB34 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAB34 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M027041: view genomic region (about GC identifiers)

Start:	27,041,299 bp from pter	End:	27,045,447 bp from pter
Size:	4,149 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NARR_HUMAN, P0DI83 (See protein sequence)

Recommended Name: Ras-related protein Rab-34, isoform NARR

Size: 198 amino acids; 21118 Da

Subunit: May interact with EIF5A and ERF1

Subcellular location: Nucleus. Nucleus, nucleolus. Note=Colocalizes with rDNA clusters

Caution: Shares its 2 exons with RAB34 but translation occurs in another frame

Alternative splicing: 3 isoforms: P0DI83-1 Q9BZG1-1 Q9BZG1-2

UniProtKB/Swiss-Prot: RAB34_HUMAN, Q9BZG1 (See protein sequence)

Recommended Name: Ras-related protein Rab-34

Size: 259 amino acids; 29044 Da

Subunit: Interacts with RILP

Subcellular location: Cytoplasm (By similarity). Golgi apparatus (By similarity). Cytoplasmic vesicle, phagosome.

Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side (By similarity). Note=Recruited to phagosomes

containing S.aureus or M.tuberculosis

Secondary accessions: B4E3A0 E9PEJ9 Q5BJE6 Q8NCJ8 Q96AR4

Alternative splicing: 4 isoforms: Q9BZG1-1 Q9BZG1-2 P0DI83-1 Q9BZG1-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RAB34: NX_Q9BZG1

Post-translational modifications:

Phosphorylated during M-phase¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9BZG1

RAB34 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (8 alternative transcripts):

NP_001136096.2 NP_001136097.2 NP_001138414.1 NP_001138415.1 NP_001243205.1 NP_001243206.1 NP_001243207.1 NP_114140.4

ENSEMBL proteins:

ENSP00000378664 ENSP00000413156 ENSP00000301043 ENSP00000391048 ENSP00000410279

ENSP00000397499 ENSP00000378663 ENSP00000378666 ENSP00000404180 ENSP00000407953

ENSP00000463488 ENSP00000226259 ENSP00000398706 ENSP00000464723 ENSP00000465352

ENSP00000410403

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: RAB34 OriGene Protein Over-expression Lysate (see all 4): RAB34 OriGene Custom Protein Services for RAB34
	GenScript Custom Purified and Recombinant Proteins Services for RAB34
	Novus Biologicals RAB34 Proteins Novus Biologicals RAB34 Lysate
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for RAB34
	Uscn Proteins for RAB34

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001726	ruffle	--	--
GO:0005769	early endosome	--	--
GO:0005794	Golgi apparatus	IEA	--
GO:0030670	phagocytic vesicle membrane	IEA	--
GO:0045335	phagocytic vesicle	IDA	--

RAB34 for ontologies About GeneDecksing

RAB34 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for RAB34
	GenScript Custom Superior Antibodies Services for RAB34
	Novus Biologicals RAB34 Antibodies
	Search for Antibodies for RAB34 at Abcam
	Uscn Antibodies for RAB34
	Search ThermoFisher Antibodies for RAB34

Assay Products for RAB34:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for RAB34
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for RAB34

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RAB34 for domains About GeneDecksing

3 InterPro domains/families:

IPR005225 Small_GTP-bd_dom

IPR001806 Small_GTPase

IPR003579 Small_GTPase_Rab_type

Graphical View of Domain Structure for InterPro Entry P0DI83

Graphical View of Domain Structure for InterPro Entry Q9BZG1

ProtoNet protein and cluster: P0DI83

UniProtKB/Swiss-Prot: RAB34_HUMAN, Q9BZG1

Similarity: Belongs to the small GTPase superfamily. Rab family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: RAB34_HUMAN, Q9BZG1

Function: Protein transport. Involved in the redistribution of lysosomes to the peri-Golgi region (By similarity).

Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role

in the fusion of phagosomes with lysosomes

miRNA Products:		miRTarBase miRNAs that target RAB34: hsa-mir-9 (MIRT001202), hsa-mir-155 (MIRT001511)

		OriGene 3'-UTR Clone (see all 5): RAB34 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAB34
		8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate RAB34 (see all 29):
		hsa-miR-3910 hsa-miR-148b hsa-miR-128 hsa-miR-1271 hsa-miR-301a hsa-miR-124 hsa-miR-661 hsa-miR-9

		SwitchGear 3'UTR luciferase reporter plasmid: RAB34 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAB34 (see all 7) OriGene shRNA RFP: RAB34 OriGene siRNA: RAB34
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAB34

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for RAB34

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAB34 (see all 8) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAB34 (see all 5) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 5): RAB34 (NM_031934)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAB34
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB34

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RAB34
		Search LifeMap BioReagents cell lines for RAB34

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB34

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003924	GTPase activity	--	--
GO:0005525	GTP binding	IEA	--
GO:0019001	guanyl nucleotide binding	--	--

RAB34 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for RAB34:

Decreased cilium length after

Animal Models:
1 MGI phenotypic allele

for Rab34 (no phenotypes)

RAB34 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Sertoli-Sertoli Cell Junction Dynamics

Epithelial Tight Junctions

0.36

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RAB34

Epithelial Tight Junctions

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for RAB34

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

5/9 Interacting proteins for RAB34 (Q9BZG1³ ENSP00000410403⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 9)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SMAD2	Q15796³, ENSP00000262160⁴	I2D: score=1 STRING: ENSP00000262160
SMAD1	Q15797³, ENSP00000305769⁴	I2D: score=1 STRING: ENSP00000305769
SMAD4	Q13485³, ENSP00000341551⁴	I2D: score=1 STRING: ENSP00000341551
TGFBR1	P36897³, ENSP00000364133⁴	I2D: score=1 STRING: ENSP00000364133
RABGAP1	Q9Y3P9³	I2D: score=1

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006184	GTP catabolic process	--	--
GO:0006897	endocytosis	--	--
GO:0007264	small GTPase mediated signal transduction	IEA	--
GO:0015031	protein transport	IEA	--
GO:0090382	phagosome maturation	IMP	--

RAB34 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RAB34
Search CenterWatch for drugs/clinical trials and news about RAB34

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RAB34 gene (8 alternative transcripts):

NM_001142624.2 NM_001142625.2 NM_001144942.1 NM_001144943.1 NM_001256276.1 NM_001256277.1 NM_001256278.1 NM_031934.5

Unigene Cluster for RAB34:

RAB34, member RAS oncogene family

Hs.301853 [show with all ESTs]

Unigene Representative Sequence: NM_031934

18/23 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):

ENST00000395243 ENST00000453384 ENST00000301043(uc002hch.2 uc010wau.1)

ENST00000450529 ENST00000415040 ENST00000484161 ENST00000422279 ENST00000395242

ENST00000474704 ENST00000395245(uc002hce.2 uc002hcg.2) ENST00000436730

ENST00000430132 ENST00000583538 ENST00000353676 ENST00000412625 ENST00000496866

ENST00000419712 ENST00000481501

miRNA Products:		OriGene 3'-UTR Clone (see all 5): RAB34 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAB34
		8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate RAB34 (see all 29):
		hsa-miR-3910 hsa-miR-148b hsa-miR-128 hsa-miR-1271 hsa-miR-301a hsa-miR-124 hsa-miR-661 hsa-miR-9

		SwitchGear 3'UTR luciferase reporter plasmid: RAB34 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAB34 (see all 7) OriGene shRNA RFP: RAB34 OriGene siRNA: RAB34
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAB34

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAB34 (see all 8) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAB34 (see all 5) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 5): RAB34 (NM_031934)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAB34
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB34

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAB34 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat RAB34
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAB34
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAB34

Additional cDNA sequence:

AF322067.1 AF327350.1 AJ277106.1 AK027312.1 AK074689.1 AK297850.1 AK304633.1 BC016841.1

BC066904.1 BC091510.1 BT006702.1

24/29 DOTS entries (see all 29):

DT.91691857 DT.92443118 DT.102843818 DT.95197976 DT.100829142 DT.92443115 DT.100031106 DT.95069403

DT.100031110 DT.95368709 DT.120910257 DT.100883974 DT.100883981 DT.100883979 DT.100883985 DT.120910258

DT.100883977 DT.100883978 DT.92443119 DT.99988328 DT.100883972 DT.100883983 DT.120910261 DT.120910274

24/476 AceView cDNA sequences (see all 476):

AI005068 CR613380 CA431331 AK074689 BM982696 BM546726 BF001688 NM_031934

AI022165 CB122903 AI356567 BQ669525 AA906902 BU740050 CD518942 BQ018531

CR614283 BP354410 CR620011 BU175922 BG388390 BM716379 BU688067 BQ722500

GeneLoc Exon Structure

5/21 Alternative Splicing Database (ASD) splice patterns (SP) for RAB34 (see all 21) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	·	2c	·	2d	·	2e	·	2f	·	2g	·	2h	·	2i	·	2j	·	2k	·	2l	^	3a	·	3b	^	4a	·	4b	^	5	^	6	^	7a	·	7b	^	8a	·	8b	·
SP1:									-		-		-		-		-		-		-		-								-				-		-										-
SP2:																															-				-		-										-
SP3:																															-				-		-										-
SP4:																															-				-		-										-
SP5:									-		-		-		-		-		-		-		-								-				-		-										-

ExUns:	8c	^	9	^	10a	·	10b	^	11a	·	11b	^	12a	·	12b	·	12c	·	12d
SP1:
SP2:
SP3:	-		-
SP4:							-		-		-		-
SP5:

ECgene alternative splicing isoforms for RAB34

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RAB34 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTAGTCACTT

About this image

RAB34 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Inner Nuclear Layer

GABAergic Amacrine Cells

Amacrine, Retina

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See RAB34 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RAB34

SOURCE GeneReport for Unigene cluster: Hs.301853

UniProtKB/Swiss-Prot: NARR_HUMAN, P0DI83

Tissue specificity: Ubiquitously expressed (at protein level)

SABiosciences Custom PCR Arrays for RAB34

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAB34 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat RAB34
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAB34
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAB34

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB34

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for RAB34 gene from 4/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Details
chicken (Gallus gallus)	Aves	LOC100858849¹	ras-related protein Rab-34-like	77.07(n) 82.28(a)	100858849 XM_003642428.1 XP_003642476.1
African clawed frog (Xenopus laevis)	Amphibia	Xl.3365²	Xenopus laevis transcribed sequence with moderate similarity more	76.68(n)	BJ627400.1
zebrafish (Danio rerio)	Actinopterygii	rab34a¹	RAB34, member RAS oncogene family a	71.71(n) 75.97(a)	450074 NM_001006094.1 NP_001006094.1
fruit fly (Drosophila melanogaster)	Insecta	CG7980³	small monomeric GTPase	52(a)	62A10 --

ENSEMBL Gene Tree for RAB34 (if available)
TreeFam Gene Tree for RAB34 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RAB34 gene

RAB36²

18/79 SIMAP similar genes for RAB34 using alignment to 12 protein entries: NARR_HUMAN (see all proteins) (see all similar genes):

RAB36 rab1b RAB8B RAB8A RAB38 RAB10

RAB13 DKFZp686J06205 RAB43 RAB19 RAB15 DKFZp686J07132

RAB7A RAB11A RAB30 RAB1A RAB6A RAB1B

RAB34 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs11650262^1,2	C,H,	--	27040806(+)	`gggatC/Tacagg`	9	--	ds500¹ us2k¹		0	--	--	--	--
rs191383475^1,2		--	27041015(+)	`AAAAAG/TAAAAA`	8	--	ds500¹		0	--	--	--	--
rs79591505^1,2	F,	--	27041046(+)	`TTGGGT/CATAAG`	8	--	ds500¹		1		NA	120
rs150609915^1,2		--	27041069(+)	`GGACAC/TGTGTG`	8	--	ds500¹		0	--	--	--	--
rs72847543^1,2	C,	--	27041246(+)	`GGCCAC/TACAGT`	8	--	ds500¹		4		WA NA EA	360
rs15200^1,2	C,H	--	27041369(+)	`CTCAAA/GCACAA`	8	--	ut3¹ ese³		7		MN NS EA NA	606
rs15199^1,2	C	--	27041415(+)	`TCTCCC/TTCACT`	8	--	ut3¹ ese³		3		MN NA	188
rs115935042^1,2	C,F,	--	27041488(+)	`CTGGGG/AGCAGG`	8	--	ut3¹		1		WA	118
rs183750490^1,2	C,	--	27041630(+)	`TAGGGA/CTGGGC`	9	S I	ut3¹ mis¹		0	--	--	--	--
rs139525649^1,2	C,F	--	27041829(+)	`AATGCG/ATCGAG`	15	/R /C	mis¹ int¹		1		NA	4552

HapMap Linkage Disequilibrium report for RAB34 (27041299 - 27045447 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RAB34: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAB34

DNA2.0 Custom Variant and Variant Library Synthesis for RAB34

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RAB34 for disorders           About GeneDecksing

OMIM gene information: 610917    OMIM disorders: --

6 diseases for RAB34:    About MalaCards

intrahepatic cholangiocarcinoma kaposi's sarcoma histiocytosis cholangiocarcinoma

hyperglycemia sarcoma

Export disorders for RAB34 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RAB34 gene, integrated from 9 sources (see all 35):
(articles sorted by number of sources associating them with RAB34)

Utopia: connect your pdf to the dynamic
world of online information

A unique region of RILP distinguishes it from its related proteins in its regulation of lysosomal morphology and interaction with Rab7 and Rab34. (PubMed id 14668488)^{1, 2} Wang T.... Hong W. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Small GTPase Rah/Rab34 is associated with membrane ruffles and macropinosomes and promotes macropinosome formation. (PubMed id 12446704)^{1, 3} Sun P....Endo T. (2003)
Rab39, a novel Golgi-associated Rab GTPase from human dendritic cells involved in cellular endocytosis. (PubMed id 12684051)^{1, 9} Chen T.... Cao X. (2003)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
Identification and characterization of a novel ubiquitous nucleolar protein 'NARR' encoded by a gene overlapping the rab34 oncogene. (PubMed id 21586586)¹ Zougman A.... Wisniewski J.R. (2011)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)¹ Lee K.A....Doedens J.R. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 83871	HGNC: 16519	AceView: RAB34	Ensembl:ENSG00000109113	euGenes: HUgn83871
ECgene: RAB34	H-InvDB: RAB34

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RAB34	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for RAB34	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for RAB34 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for RAB34 gene:
Search GeneIP for patents involving RAB34

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for RAB34
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAB34		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAB34
	OriGene Protein Over-expression Lysate for RAB34		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for RAB34		OriGene 3'-UTR Clone for RAB34
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAB34		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAB34
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for RAB34		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for RAB34		OriGene Custom Protein Services for RAB34
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RAB34
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAB34
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB34
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAB34
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAB34
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAB34

	GenScript Custom Purified and Recombinant Proteins Services for RAB34		GenScript cDNA clones with any tag delivered in your preferred vector for RAB34
	GenScript Custom Assay Services for RAB34		GenScript Custom Superior Antibodies Services for RAB34
	GenScript Custom overexpressing Cell Line Services for RAB34		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in RAB34 promoter
	Search Chromatin IP Primers for RAB34
	RT² qPCR Primer Assay in human, mouse, rat RAB34
	GNC Network for RAB34
	SABiosciences PCR Arrays including human, mouse, rat RAB34

Search Tocris compounds for RAB34

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	RAB34 antibodies
	RAB34 proteins
	RAB34 lysates

	Search for Antibodies for RAB34 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for RAB34
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Recombinant Protein for RAB34

RAB34 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for RAB34

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB34

	SwitchGear 3'UTR luciferase reporter plasmids for RAB34
	SwitchGear Promoter luciferase reporter plasmids for RAB34

Search ThermoFisher Antibodies for RAB34

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB34

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes RAB34 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

RAB34 Gene

RAB34, member RAS oncogene family

Aliases
for RAB34 gene

Summaries
for RAB34 gene

Genomic Views
for RAB34 gene

Proteins
for RAB34 gene

Protein Domains /
Families
for RAB34 gene

Function
for RAB34 gene

Pathways & Interactions
for RAB34 gene

Drugs & Compounds
for RAB34 gene

Transcripts
for RAB34 gene

Expression
for RAB34 gene

Orthologs
for RAB34 gene

Paralogs
for RAB34 gene

Genomic Variants
for RAB34 gene

Disorders / Diseases
for RAB34 gene

Publications
for RAB34 gene

External Searches for RAB34 gene

Genome Databases showing RAB34 gene

Other Databases showing RAB34 gene

Specialized Databases showing RAB34 gene

Intellectual Property
for RAB34 gene

Products
for RAB34 gene

View Random Gene

Advanced Search

Export list of displayed genes

RAB34 Gene

RAB34, member RAS oncogene family

Aliasesfor RAB34 gene

Summariesfor RAB34 gene

Genomic Viewsfor RAB34 gene

Proteinsfor RAB34 gene

Protein Domains /Familiesfor RAB34 gene

Functionfor RAB34 gene

Pathways & Interactionsfor RAB34 gene

Drugs & Compoundsfor RAB34 gene

Transcriptsfor RAB34 gene

Expression for RAB34 gene

Orthologsfor RAB34 gene

Paralogsfor RAB34 gene

Genomic Variantsfor RAB34 gene

Disorders / Diseasesfor RAB34 gene

Publicationsfor RAB34 gene

External Searches for RAB34 gene

Genome Databases showing RAB34 gene

Other Databases showing RAB34 gene

Specialized Databases showing RAB34 gene

Intellectual Propertyfor RAB34 gene

Productsfor RAB34 gene

View Random Gene

Aliases
for RAB34 gene

Summaries
for RAB34 gene

Genomic Views
for RAB34 gene

Proteins
for RAB34 gene

Protein Domains /
Families
for RAB34 gene

Function
for RAB34 gene

Pathways & Interactions
for RAB34 gene

Drugs & Compounds
for RAB34 gene

Transcripts
for RAB34 gene

Expression
for RAB34 gene

Orthologs
for RAB34 gene

Paralogs
for RAB34 gene

Genomic Variants
for RAB34 gene

Disorders / Diseases
for RAB34 gene

Publications
for RAB34 gene

Intellectual Property
for RAB34 gene

Products
for RAB34 gene