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Aliases for RAB34 Gene

Aliases for RAB34 Gene

  • RAB34, Member RAS Oncogene Family 2 3 5
  • Nine Amino-Acid Residue-Repeats 3 4
  • Ras-Related Protein Rab-39 3 4
  • Ras-Related Protein Rah 3 4
  • RAB39 3 4
  • NARR 3 4
  • RAH 3 4
  • Nine-Amino Acid Residue-Repeats 2
  • Ras-Related Protein Rab-34 3

External Ids for RAB34 Gene

Previous GeneCards Identifiers for RAB34 Gene

  • GC17M026887
  • GC17M028941
  • GC17M027186
  • GC17M024065
  • GC17M027041
  • GC17M023250

Summaries for RAB34 Gene

Entrez Gene Summary for RAB34 Gene

  • This gene encodes a protein belonging to the RAB family of proteins, which are small GTPases involved in protein transport. This family member is a Golgi-bound member of the secretory pathway that is involved in the repositioning of lysosomes and the activation of macropinocytosis. Alternative splicing of this gene results in multiple transcript variants. An alternatively spliced transcript variant produces the nine-amino acid residue-repeats (NARR) protein, which is a functionally distinct nucleolar protein resulting from a different reading frame. [provided by RefSeq, Dec 2016]

GeneCards Summary for RAB34 Gene

RAB34 (RAB34, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB34 include Low Compliance Bladder. Among its related pathways are RAB geranylgeranylation and Metabolism of proteins. GO annotations related to this gene include GTP binding and guanyl nucleotide binding. An important paralog of this gene is RAB36.

UniProtKB/Swiss-Prot for RAB34 Gene

  • Protein transport. Involved in the redistribution of lysosomes to the peri-Golgi region (By similarity). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes.

Gene Wiki entry for RAB34 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB34 Gene

Genomics for RAB34 Gene

Regulatory Elements for RAB34 Gene

Enhancers for RAB34 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G028863 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.7 -146.9 -146908 3.3 HDGF CREB3L1 ARNT ARID4B ZNF766 CBX5 FOS KLF13 JUNB REST DHRS13 PROCA1 FLOT2 NEK8 TLCD1 SNORD42A SNORD4B SNORD42B RAB34 RPL23A
GH17G028760 1.5 Ensembl ENCODE dbSUPER 11.8 -42.8 -42843 2.2 CREB3L1 ARNT SIN3A YBX1 ETS1 ZNF766 ELK1 KLF13 ZNF592 MEF2D TRAF4 TLCD1 NEK8 SNORD42A SNORD4B ERAL1 FAM222B SNORD4A RAB34 SNORD42B
GH17G028807 1.6 FANTOM5 ENCODE dbSUPER 10.7 -92.0 -92011 6.8 HDGF PKNOX1 CREB3L1 ARNT AGO1 SIN3A FEZF1 DMAP1 ZNF2 YY1 TRAF4 ENSG00000264577 ENSG00000265205 NUFIP2 ENSG00000265908 ERAL1 FAM222B FLOT2 DHRS13 LOC101927018
GH17G028764 1.1 ENCODE dbSUPER 11.8 -45.5 -45489 0.2 HDAC1 HDGF ATF1 NFIB WRNIP1 ARID4B BMI1 ZNF2 RAD21 RFX5 ENSG00000264577 NEK8 TLCD1 SNORD42A SNORD4B NUFIP2 ERAL1 FAM222B RPL23A SNORD42B
GH17G028911 1.2 ENCODE dbSUPER 10.6 -193.9 -193897 1.3 PKNOX1 ATF1 CREB3L1 ARNT TCF12 ZNF766 GATA2 JUNB REST ZNF623 FAM222B ERAL1 SNORD42A SNORD4A RAB34 RPL23A SNORD42B DHRS13 LOC101927018
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RAB34 on UCSC Golden Path with GeneCards custom track

Promoters for RAB34 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000282989 929 1401 FOXA2 SIN3A GLIS2 FOS SP3 SMARCB1 ZNF610 GLIS1 PRDM4 SP7
ENSR00000092756 -1871 2201 HDGF PKNOX1 FOXA2 CREB3L1 ARNT ZFP64 WRNIP1 ARID4B SIN3A DMAP1

Genomic Location for RAB34 Gene

Chromosome:
17
Start:
28,714,281 bp from pter
End:
28,718,429 bp from pter
Size:
4,149 bases
Orientation:
Minus strand

Genomic View for RAB34 Gene

Genes around RAB34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB34 Gene

Proteins for RAB34 Gene

  • Protein details for RAB34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DI83-NARR_HUMAN
    Recommended name:
    Ras-related protein Rab-34, isoform NARR
    Protein Accession:
    P0DI83

    Protein attributes for RAB34 Gene

    Size:
    198 amino acids
    Molecular mass:
    21118 Da
    Quaternary structure:
    • May interact with EIF5A and ERF1.

    Alternative splice isoforms for RAB34 Gene

    UniProtKB/Swiss-Prot:
  • Protein details for RAB34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZG1-RAB34_HUMAN
    Recommended name:
    Ras-related protein Rab-34
    Protein Accession:
    Q9BZG1
    Secondary Accessions:
    • B4E3A0
    • E9PEJ9
    • Q5BJE6
    • Q8NCJ8
    • Q96AR4

    Protein attributes for RAB34 Gene

    Size:
    259 amino acids
    Molecular mass:
    29044 Da
    Quaternary structure:
    • Interacts with RILP.

    Alternative splice isoforms for RAB34 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAB34 Gene

Post-translational modifications for RAB34 Gene

Antibody Products

  • Abcam antibodies for RAB34

No data available for DME Specific Peptides for RAB34 Gene

Domains & Families for RAB34 Gene

Gene Families for RAB34 Gene

Protein Domains for RAB34 Gene

Suggested Antigen Peptide Sequences for RAB34 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BZG1

UniProtKB/Swiss-Prot:

RAB34_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB34: view

Function for RAB34 Gene

Molecular function for RAB34 Gene

UniProtKB/Swiss-Prot Function:
Protein transport. Involved in the redistribution of lysosomes to the peri-Golgi region (By similarity). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes.

Gene Ontology (GO) - Molecular Function for RAB34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005515 protein binding IPI 16138900
GO:0005525 GTP binding IEA --
GO:0017160 Ral GTPase binding IPI 24056301
GO:0030742 GTP-dependent protein binding IPI 16138900
genes like me logo Genes that share ontologies with RAB34: view
genes like me logo Genes that share phenotypes with RAB34: view

Animal Models for RAB34 Gene

MGI Knock Outs for RAB34:

Animal Model Products

  • Taconic Biosciences Mouse Models for RAB34

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RAB34 Gene

Localization for RAB34 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB34 Gene

Nucleus. Nucleus, nucleolus. Note=Colocalizes with rDNA clusters.
Cytoplasm. Golgi apparatus. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB34 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
nucleus 4
cytosol 3
lysosome 2
endosome 2

Gene Ontology (GO) - Cellular Components for RAB34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IDA,IEA 16138900
genes like me logo Genes that share ontologies with RAB34: view

Pathways & Interactions for RAB34 Gene

genes like me logo Genes that share pathways with RAB34: view

Pathways by source for RAB34 Gene

Interacting Proteins for RAB34 Gene

Gene Ontology (GO) - Biological Process for RAB34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0015031 protein transport IEA --
GO:0019882 antigen processing and presentation IMP 19717423
GO:0032418 lysosome localization IDA 17881736
genes like me logo Genes that share ontologies with RAB34: view

No data available for SIGNOR curated interactions for RAB34 Gene

Drugs & Compounds for RAB34 Gene

No Compound Related Data Available

Transcripts for RAB34 Gene

Unigene Clusters for RAB34 Gene

RAB34, member RAS oncogene family:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAB34 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g · 2h · 2i · 2j · 2k · 2l ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ·
SP1: - - - - - - - - - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - -
SP5: - - - - - - - - - - - -
SP6: - - - - -
SP7: - - - -
SP8: - - - - - - - -
SP9: - - - - - - - - - - - -
SP10: - - - - - -
SP11: - - - - -
SP12: - - - - - - - - - - - - - - - -
SP13: - - - - - - - - - - - -
SP14: - - - - - -
SP15: - -
SP16: - - - -
SP17: - - -
SP18: - - - - - - - - -
SP19:
SP20:
SP21: - - - - - - - -

ExUns: 8c ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c · 12d
SP1:
SP2:
SP3: - -
SP4: - - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:

Relevant External Links for RAB34 Gene

GeneLoc Exon Structure for
RAB34
ECgene alternative splicing isoforms for
RAB34

Expression for RAB34 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAB34 Gene

Protein differential expression in normal tissues from HIPED for RAB34 Gene

This gene is overexpressed in Breast (17.1) and Uterus (15.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RAB34 Gene



Protein tissue co-expression partners for RAB34 Gene

NURSA nuclear receptor signaling pathways regulating expression of RAB34 Gene:

RAB34

SOURCE GeneReport for Unigene cluster for RAB34 Gene:

Hs.301853

Evidence on tissue expression from TISSUES for RAB34 Gene

  • Nervous system(4.8)
  • Pancreas(4.4)
  • Muscle(4.3)
  • Lung(3.1)
  • Kidney(2)
genes like me logo Genes that share expression patterns with RAB34: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAB34 Gene

Orthologs for RAB34 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAB34 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB34 34 35
  • 99.68 (n)
dog
(Canis familiaris)
Mammalia RAB34 34 35
  • 92.79 (n)
cow
(Bos Taurus)
Mammalia RAB34 34 35
  • 91.01 (n)
rat
(Rattus norvegicus)
Mammalia Rab34 34
  • 89.32 (n)
mouse
(Mus musculus)
Mammalia Rab34 34 16 35
  • 89.19 (n)
oppossum
(Monodelphis domestica)
Mammalia RAB34 35
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAB34 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAB34 35
  • 82 (a)
OneToOne
LOC100858849 34
  • 77.17 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia rab34 34
  • 74.94 (n)
Str.2247 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.3365 34
zebrafish
(Danio rerio)
Actinopterygii rab34a 34 35
  • 71.71 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7980 36
  • 52 (a)
RabX5 35
  • 38 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y71H2AM.12 35
  • 31 (a)
ManyToMany
C56E6.2 35
  • 22 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPT6 35
  • 30 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 49 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.67 34
Species where no ortholog for RAB34 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB34 Gene

ENSEMBL:
Gene Tree for RAB34 (if available)
TreeFam:
Gene Tree for RAB34 (if available)

Paralogs for RAB34 Gene

Paralogs for RAB34 Gene

genes like me logo Genes that share paralogs with RAB34: view

Variants for RAB34 Gene

Sequence variations from dbSNP and Humsavar for RAB34 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1001110218 -- 28,716,278(+) TCACA(C/T)TGATT intron-variant
rs1001198027 -- 28,716,363(+) TTTTA(C/T)TGGGT intron-variant
rs1002162539 -- 28,718,946(+) AACTT(C/G)ACAGT upstream-variant-2KB
rs1002499492 -- 28,719,715(+) TTACA(-/GTGAGCCGAGATCGCGCC)ACTGC upstream-variant-2KB
rs1002511645 -- 28,718,579(+) TGGAA(G/T)CTATC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RAB34 Gene

Variant ID Type Subtype PubMed ID
nsv1064087 CNV gain 25217958
nsv1064087 CNV gain 25217958

Variation tolerance for RAB34 Gene

Residual Variation Intolerance Score: 36% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.52; 11.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAB34 Gene

Human Gene Mutation Database (HGMD)
RAB34
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAB34

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB34 Gene

Disorders for RAB34 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RAB34 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
low compliance bladder
  • hyperactivity of bladder
- elite association - COSMIC cancer census association via MalaCards
Search RAB34 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RAB34

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAB34
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAB34
genes like me logo Genes that share disorders with RAB34: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RAB34 Gene

Publications for RAB34 Gene

  1. Identification and characterization of a novel ubiquitous nucleolar protein 'NARR' encoded by a gene overlapping the rab34 oncogene. (PMID: 21586586) Zougman A. … Wisniewski J.R. (Nucleic Acids Res. 2011) 2 3 64
  2. Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes. (PMID: 21255211) Seto S. … Koide Y. (Traffic 2011) 3 4 64
  3. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 3 4 64
  4. A unique region of RILP distinguishes it from its related proteins in its regulation of lysosomal morphology and interaction with Rab7 and Rab34. (PMID: 14668488) Wang T. … Hong W. (Mol. Biol. Cell 2004) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for RAB34 Gene

Sources for RAB34 Gene

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