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RAB34 Gene

protein-coding   GIFtS: 56
GCID: GC17M027041

RAB34, Member RAS Oncogene Family

  Search for RAB34
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RAB34, Member RAS Oncogene Family1 2     RAB392 3
RAH2 3 5     Ras-Related Protein Rab-342
Ras-Related Protein Rab-392 3     NARR3
Ras-Related Protein Rah2 3     Nine Amino-Acid Residue-Repeats3

External Ids:    HGNC: 165191   Entrez Gene: 838712   Ensembl: ENSG000001091137   OMIM: 6109175   UniProtKB: P0DI833   
UniProtKB: Q9BZG13   

Export aliases for RAB34 gene to outside databases

Previous GC identifers: GC17M026887 GC17M028941 GC17M027186 GC17M024065 GC17M023250


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RAB34 Gene:
This gene encodes a protein belonging to the RAB family of proteins, which are small GTPases involved in protein
transport. This family member is a Golgi-bound member of the secretory pathway that is involved in the
repositioning of lysosomes and the activation of macropinocytosis. Alternative splicing of this gene results in
multiple transcript variants. This gene overlaps and shares exon structure with the nine-amino acid
residue-repeats (NARR) gene, which encodes a functionally distinct nucleolar protein from a different reading
frame. (provided by RefSeq, Jan 2012)

GeneCards Summary for RAB34 Gene:
RAB34 (RAB34, member RAS oncogene family) is a protein-coding gene. GO annotations related to this gene include GTP binding. An important paralog of this gene is RAB6C.

UniProtKB/Swiss-Prot: RAB34_HUMAN, Q9BZG1
Function: Protein transport. Involved in the redistribution of lysosomes to the peri-Golgi region (By similarity).
Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a
role in the fusion of phagosomes with lysosomes

Gene Wiki entry for RAB34 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the RAB34 gene promoter:
         AP-1   ATF-2   c-Jun   Tal-1beta   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRAB34 promoter sequence
   Search Chromatin IP Primers for RAB34

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RAB34


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q11.2   HGNC cytogenetic band: 17q11.2

RAB34 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAB34 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M027041:  view genomic region     (about GC identifiers)

Start:
27,041,299 bp from pter      End:
27,045,447 bp from pter
Size:
4,149 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NARR_HUMAN, P0DI83 (See protein sequence)
Recommended Name: Ras-related protein Rab-34, isoform NARR  
Size: 198 amino acids; 21118 Da
Subunit: May interact with EIF5A and ERF1
Caution: Shares its 2 exons with RAB34 but translation occurs in another frame
Alternative splicing: 3 isoforms:  P0DI83-1   Q9BZG1-1   Q9BZG1-2   

UniProtKB/Swiss-Prot: RAB34_HUMAN, Q9BZG1 (See protein sequence)

Recommended Name: Ras-related protein Rab-34  
Size: 259 amino acids; 29044 Da
Subunit: Interacts with RILP
Secondary accessions: B4E3A0 E9PEJ9 Q5BJE6 Q8NCJ8 Q96AR4
Alternative splicing: 4 isoforms:  Q9BZG1-1   Q9BZG1-2   P0DI83-1   Q9BZG1-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RAB34: NX_Q9BZG1

Explore proteomics data for RAB34 at MOPED

Post-translational modifications: 

  • Phosphorylated during M-phase1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RAB34 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (8 alternative transcripts): 
    NP_001136096.2  NP_001136097.2  NP_001138414.1  NP_001138415.1  NP_001243205.1  NP_001243206.1  NP_001243207.1  NP_114140.4  

    ENSEMBL proteins: 
     ENSP00000378664   ENSP00000413156   ENSP00000301043   ENSP00000391048   ENSP00000410279  
     ENSP00000397499   ENSP00000378663   ENSP00000378666   ENSP00000404180   ENSP00000407953  
     ENSP00000463488   ENSP00000226259   ENSP00000398706   ENSP00000464723   ENSP00000465352  
     ENSP00000476427   ENSP00000410403  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RAB: RAB, member RAS oncogene

    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR003579 Small_GTPase_Rab_type
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry P0DI83
    Graphical View of Domain Structure for InterPro Entry Q9BZG1

    ProtoNet protein and cluster: P0DI83

    UniProtKB/Swiss-Prot: RAB34_HUMAN, Q9BZG1
    Similarity: Belongs to the small GTPase superfamily. Rab family


    Find genes that share domains with RAB34           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RAB34_HUMAN, Q9BZG1
    Function: Protein transport. Involved in the redistribution of lysosomes to the peri-Golgi region (By similarity).
    Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a
    role in the fusion of phagosomes with lysosomes

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity ----
    GO:0005515protein binding IPI16138900
    GO:0005525GTP binding IEA--
    GO:0019001guanyl nucleotide binding ----
         
    Find genes that share ontologies with RAB34           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for RAB34:
     Decreased cilium length after  

         1 MGI phenotypic allele for Rab34 (no phenotypes)

    Find genes that share phenotypes with RAB34           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RAB34
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    miRNA
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    miRTarBase miRNAs that target RAB34:
    hsa-mir-124-3p (MIRT022170), hsa-let-7c-5p (MIRT051828), hsa-mir-130b-3p (MIRT020139), hsa-mir-1 (MIRT023490), hsa-mir-148a-3p (MIRT026008), hsa-mir-30a-5p (MIRT028393), hsa-mir-9-5p (MIRT001202), hsa-mir-19b-3p (MIRT031104), hsa-mir-93-3p (MIRT038817), hsa-mir-155-5p (MIRT001511)

    Block miRNA regulation of human, mouse, rat RAB34 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RAB34 (see all 29):
    hsa-miR-3910 hsa-miR-148b hsa-miR-128 hsa-miR-1271 hsa-miR-301a hsa-miR-124 hsa-miR-661 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidRAB34 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RAB34

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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB34

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB34


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NARR_HUMAN, P0DI83: Nucleus. Nucleus, nucleolus. Note=Colocalizes with rDNA clusters
    RAB34_HUMAN, Q9BZG1: Cytoplasm (By similarity). Golgi apparatus (By similarity). Cytoplasmic vesicle, phagosome.
    Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side (By similarity). Note=Recruited to
    phagosomes containing S.aureus or M.tuberculosis
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    endosome2
    golgi apparatus2
    lysosome2
    nucleus2
    vacuole2
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726NOT ruffle IDA17881736
    GO:0005622intracellular ----
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0005769early endosome ----

    Find genes that share ontologies with RAB34           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RAB34 About    
    See pathways by source

    SuperPathContained pathways About
    1Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions0.36

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for RAB34
        Epithelial Tight Junctions


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RAB34
    Interactions:

        GeneGlobe Interaction Network for RAB34

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RAB34 (Q9BZG13 ENSP000004104034) via UniProtKB, MINT, STRING, and/or I2D (see all 120)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD2Q157963, ENSP000002621604I2D: score=1 STRING: ENSP00000262160
    SMAD1Q157973, ENSP000003057694I2D: score=1 STRING: ENSP00000305769
    SMAD4Q134853, ENSP000003415514I2D: score=1 STRING: ENSP00000341551
    TGFBR1P368973, ENSP000003641334I2D: score=1 STRING: ENSP00000364133
    RABGAP1Q9Y3P93I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process ----
    GO:0006886intracellular protein transport ----
    GO:0006897endocytosis ----
    GO:0006913nucleocytoplasmic transport ----
    GO:0007165signal transduction ----

    Find genes that share ontologies with RAB34           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RAB34



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RAB34 gene (8 alternative transcripts): 
    NM_001142624.2  NM_001142625.2  NM_001144942.1  NM_001144943.1  NM_001256276.1  NM_001256277.1  NM_001256278.1  NM_031934.5  

    Unigene Cluster for RAB34:

    RAB34, member RAS oncogene family
    Hs.301853  [show with all ESTs]
    Unigene Representative Sequence: NM_031934
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):
    ENST00000395243 ENST00000453384 ENST00000301043(uc002hch.2 uc010wau.1)
    ENST00000450529 ENST00000415040 ENST00000484161 ENST00000422279 ENST00000395242
    ENST00000474704 ENST00000395245(uc002hce.2 uc002hcg.2) ENST00000436730
    ENST00000430132 ENST00000583538 ENST00000353676 ENST00000412625 ENST00000496866
    ENST00000419712 ENST00000481501
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate RAB34 (see all 29):
    hsa-miR-3910 hsa-miR-148b hsa-miR-128 hsa-miR-1271 hsa-miR-301a hsa-miR-124 hsa-miR-661 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidRAB34 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 5): RAB34 (NM_031934)
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      QuantiTect SYBR Green Assays in human, mouse, rat RAB34
      QuantiFast Probe-based Assays in human, mouse, rat RAB34

    Additional mRNA sequence: 

    AF322067.1 AF327350.1 AJ277106.1 AK027312.1 AK074689.1 AK297850.1 AK304633.1 BC016841.1 
    BC066904.1 BC091510.1 BT006702.1 

    Selected DOTS entries (see all 29):

    DT.91691857  DT.92443118  DT.102843818  DT.95197976  DT.100829142  DT.92443115  DT.100031106  DT.95069403 
    DT.100031110  DT.95368709  DT.120910257  DT.100883974  DT.100883981  DT.100883979  DT.100883985  DT.120910258 
    DT.100883977  DT.100883978  DT.92443119  DT.99988328  DT.100883972  DT.100883983  DT.120910261  DT.120910274 

    Selected AceView cDNA sequences (see all 476):

    BQ962073 AK074689 BU684477 BM474462 CA391582 AI082082 CA310126 AI573072 
    BQ018531 AI022165 C00453 BE219045 BM047129 BM728685 CR613380 BQ674626 
    BC016841 CR612137 AF322067 BP354518 CR614283 AW769494 BQ925081 NM_031934 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RAB34 (see all 21)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g · 2h · 2i · 2j · 2k · 2l ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ·
    SP1:                          -     -     -     -     -     -     -     -                       -           -     -                             -               
    SP2:                                                                                            -           -     -                             -               
    SP3:                                                                                            -           -     -                             -               
    SP4:                                                                                            -           -     -                             -               
    SP5:                          -     -     -     -     -     -     -     -                       -           -     -                             -               

    ExUns: 8c ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c · 12d
    SP1:                                                            
    SP2:                                                            
    SP3:  -     -                                                   
    SP4:                    -     -     -     -                     
    SP5:                                                            


    ECgene alternative splicing isoforms for RAB34

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RAB34 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTAGTCACTT
    RAB34 Expression
    About this image


    RAB34 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Eye (Sensory Organs)
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    RAB34 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RAB34 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.301853

    UniProtKB/Swiss-Prot: NARR_HUMAN, P0DI83
    Tissue specificity: Ubiquitously expressed (at protein level)


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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB34

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RAB34 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rab341 , 5 RAB34, member of RAS oncogene family1, 5 89.19(n)1
    94.98(a)1
      11 (46.74 cM)5
    193761  NM_001159482.11  NP_001152954.11 
     781884305 
    chicken
    (Gallus gallus)
    Aves LOC1008588491 ras-related protein Rab-34-like 77.17(n)
    82.35(a)
      100858849  XM_004946577.1  XP_004946634.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.33652 Xenopus laevis transcribed sequence with moderate similarity more 76.68(n)    BJ627400.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rab34a1 RAB34, member RAS oncogene family a 71.71(n)
    75.97(a)
      450074  NM_001006094.1  NP_001006094.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG79803 small monomeric GTPase 52(a)   62A10   --
    worm
    (Caenorhabditis elegans)
    Secernentea Y71H2AM.126
    C56E6.26
    Protein C56E6.2 (C56E6.2) mRNA, complete cds
    31(a)
    22(a)
    many ↔ many
    many ↔ many
    III(2731340-2734011) WBGene00022177
    II(6524927-6526337) WBGene00016970
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YPT66
    Rab family GTPase, Ras-like GTP binding protein in...
    30(a)
    1 → many
    XII(668244-668891) YLR262C


    ENSEMBL Gene Tree for RAB34 (if available)
    TreeFam Gene Tree for RAB34 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RAB34 gene
    RAB6C2  RAB6A2  RAB412  RAB362  RAB6B2  
    Selected SIMAP similar genes for RAB34 using alignment to 13 protein entries:     NARR_HUMAN (see all proteins) (see all similar genes):
    RAB36    rab1b    RAB8B    RAB8A    RAB38    RAB10
    RAB13    DKFZp686J06205    RAB43    RAB19    RAB15    DKFZp686J07132
    RAB7A    RAB30    RAB11A    RAB3A    RAB1A    RAB1B

    Find genes that share paralogs with RAB34           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RAB34 (see all 54)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1913834751,2
    --27041015(+) AAAAAG/TAAAAA 8 -- ds50010--------
    rs795915051,2
    C,F--27041046(+) TTGGGT/CATAAG 8 -- ds50011Minor allele frequency- C:0.02NA 120
    rs1506099151,2
    --27041069(+) GGACAC/TGTGTG 8 -- ds50010--------
    rs728475431,2
    C--27041246(+) GGCCAC/TACAGT 8 -- ds50014Minor allele frequency- T:0.12WA NA EA 360
    rs152001,2
    C,H--27041369(+) CTCAAA/GCACAA 8 -- ut31 ese37Minor allele frequency- G:0.00MN NS EA NA 606
    rs151991,2
    C--27041415(+) TCTCCC/TTCACT 8 -- ut31 ese33Minor allele frequency- T:0.00MN NA 188
    rs1159350421,2
    C,F--27041488(+) CTGGGG/AGCAGG 8 -- ut311Minor allele frequency- A:0.03WA 118
    rs1837504901,2
    C--27041630(+) TAGGGA/CTGGGC 9 S I ut31 mis10--------
    rs1395256491,2
    C,F--27041829(+) AATGCG/ATCGAG 15 /R /C mis1 int11Minor allele frequency- A:0.00NA 4552
    rs1392197281,2
    C--27041907(+) TTCTCA/GGACAT 15 R * stg1 int10--------

    HapMap Linkage Disequilibrium report for RAB34 (27041299 - 27045447 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RAB34:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv908028CNV Loss21882294

    Human Gene Mutation Database (HGMD): RAB34
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RAB34
    DNA2.0 Custom Variant and Variant Library Synthesis for RAB34

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610917    OMIM disorders: --


    Find genes that share disorders with RAB34           About GenesLikeMe


    Export disorders for RAB34 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RAB34 gene, integrated from 10 sources (see all 42):
    (articles sorted by number of sources associating them with RAB34)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A unique region of RILP distinguishes it from its related proteins in its regulation of lysosomal morphology and interaction with Rab7 and Rab34. (PubMed id 14668488)1, 2 Wang T.... Hong W. (Mol. Biol. Cell 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Small GTPase Rah/Rab34 is associated with membrane ruffles and macropinosomes and promotes macropinosome formation. (PubMed id 12446704)1, 3 Sun P....Endo T. (J. Biol. Chem. 2003)
    5. Rab39, a novel Golgi-associated Rab GTPase from human dendritic cells involved in cellular endocytosis. (PubMed id 12684051)1, 9 Chen T.... Cao X. (Biochem. Biophys. Res. Commun. 2003)
    6. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. (PubMed id 23453885)1 (Lancet 2013)
    7. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)
    8. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    9. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 83871 HGNC: 16519 AceView: RAB34 Ensembl:ENSG00000109113 euGenes: HUgn83871
    ECgene: RAB34 H-InvDB: RAB34

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RAB34 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAB34 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RAB34 gene:
    Search GeneIP for patents involving RAB34

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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