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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RAB34 Gene

protein-coding   GIFtS: 57
GCID: GC17M027041

RAB34, Member RAS Oncogene Family

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
RAB34, Member RAS Oncogene Family1 2     RAB392 3
RAH2 3 5     Ras-Related Protein Rab-342
Ras-Related Protein Rab-392 3     NARR3
Ras-Related Protein Rah2 3     Nine Amino-Acid Residue-Repeats3

External Ids:    HGNC: 165191   Entrez Gene: 838712   Ensembl: ENSG000001091137   OMIM: 6109175   UniProtKB: P0DI833   
UniProtKB: Q9BZG13   
ORGUL members:         
NONCODE14:n407078      

Export aliases for RAB34 gene to outside databases

Previous GC identifers: GC17M026887 GC17M028941 GC17M027186 GC17M024065 GC17M023250


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RAB34 Gene:
This gene encodes a protein belonging to the RAB family of proteins, which are small GTPases involved in protein
transport. This family member is a Golgi-bound member of the secretory pathway that is involved in the
repositioning of lysosomes and the activation of macropinocytosis. Alternative splicing of this gene results in
multiple transcript variants. This gene overlaps and shares exon structure with the nine-amino acid
residue-repeats (NARR) gene, which encodes a functionally distinct nucleolar protein from a different reading
frame. (provided by RefSeq, Jan 2012)

GeneCards Summary for RAB34 Gene: 
RAB34 (RAB34, member RAS oncogene family) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with RAB34 include histiocytosis, and intrahepatic cholangiocarcinoma, and among its related super-pathways are Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include GTP binding. An important paralog of this gene is RAB6C.

UniProtKB/Swiss-Prot: RAB34_HUMAN, Q9BZG1
Function: Protein transport. Involved in the redistribution of lysosomes to the peri-Golgi region (By similarity).
Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a
role in the fusion of phagosomes with lysosomes

Gene Wiki entry for RAB34 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010799.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RAB34 gene promoter:
         AP-1   ATF-2   c-Jun   Tal-1beta   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRAB34 promoter sequence
   Search SABiosciences Chromatin IP Primers for RAB34

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB34


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q11.2   HGNC cytogenetic band: 17q11.2

RAB34 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAB34 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M027041:  view genomic region     (about GC identifiers)

Start:
27,041,299 bp from pter      End:
27,045,447 bp from pter
Size:
4,149 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NARR_HUMAN, P0DI83 (See protein sequence)
Recommended Name: Ras-related protein Rab-34, isoform NARR  
Size: 198 amino acids; 21118 Da
Subunit: May interact with EIF5A and ERF1
Subcellular location: Nucleus. Nucleus, nucleolus. Note=Colocalizes with rDNA clusters
Caution: Shares its 2 exons with RAB34 but translation occurs in another frame
Alternative splicing: 3 isoforms:  P0DI83-1   Q9BZG1-1   Q9BZG1-2   

UniProtKB/Swiss-Prot: RAB34_HUMAN, Q9BZG1 (See protein sequence)

Recommended Name: Ras-related protein Rab-34  
Size: 259 amino acids; 29044 Da
Subunit: Interacts with RILP
Subcellular location: Cytoplasm (By similarity). Golgi apparatus (By similarity). Cytoplasmic vesicle, phagosome.
Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side (By similarity). Note=Recruited to
phagosomes containing S.aureus or M.tuberculosis
Secondary accessions: B4E3A0 E9PEJ9 Q5BJE6 Q8NCJ8 Q96AR4
Alternative splicing: 4 isoforms:  Q9BZG1-1   Q9BZG1-2   P0DI83-1   Q9BZG1-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RAB34: NX_Q9BZG1

Explore proteomics data for RAB34 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated during M-phase
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BZG1

  • RAB34 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RAB34 Protein Expression
    REFSEQ proteins (8 alternative transcripts): 
    NP_001136096.2  NP_001136097.2  NP_001138414.1  NP_001138415.1  NP_001243205.1  NP_001243206.1  NP_001243207.1  NP_114140.4  

    ENSEMBL proteins: 
     ENSP00000378664   ENSP00000413156   ENSP00000301043   ENSP00000391048   ENSP00000410279  
     ENSP00000397499   ENSP00000378663   ENSP00000378666   ENSP00000404180   ENSP00000407953  
     ENSP00000463488   ENSP00000226259   ENSP00000398706   ENSP00000464723   ENSP00000465352  
     ENSP00000410403  

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    Novus Biologicals RAB34 Proteins
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    ProSpec Recombinant Protein for RAB34
    Cloud-Clone Corp. Proteins for RAB34 

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle ----
    GO:0005622intracellular ----
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0005769early endosome ----

    RAB34 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RAB: RAB, member RAS oncogene

    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR003579 Small_GTPase_Rab_type
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry P0DI83
    Graphical View of Domain Structure for InterPro Entry Q9BZG1

    ProtoNet protein and cluster: P0DI83

    UniProtKB/Swiss-Prot: RAB34_HUMAN, Q9BZG1
    Similarity: Belongs to the small GTPase superfamily. Rab family


    RAB34 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RAB34_HUMAN, Q9BZG1
    Function: Protein transport. Involved in the redistribution of lysosomes to the peri-Golgi region (By similarity).
    Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a
    role in the fusion of phagosomes with lysosomes

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity ----
    GO:0005525GTP binding IEA--
    GO:0019001guanyl nucleotide binding ----
         
    RAB34 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RAB34:
     Decreased cilium length after  

         1 MGI phenotypic allele for Rab34 (no phenotypes)

    RAB34 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RAB34 
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    miRTarBase miRNAs that target RAB34:
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    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate RAB34 (see all 29):
    hsa-miR-3910 hsa-miR-148b hsa-miR-128 hsa-miR-1271 hsa-miR-301a hsa-miR-124 hsa-miR-661 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidRAB34 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB34


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RAB34 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions0.36

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RAB34
        Epithelial Tight Junctions


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAB34

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/9 Interacting proteins for RAB34 (Q9BZG13 ENSP000004104034) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD2Q157963, ENSP000002621604I2D: score=1 STRING: ENSP00000262160
    SMAD1Q157973, ENSP000003057694I2D: score=1 STRING: ENSP00000305769
    SMAD4Q134853, ENSP000003415514I2D: score=1 STRING: ENSP00000341551
    TGFBR1P368973, ENSP000003641334I2D: score=1 STRING: ENSP00000364133
    RABGAP1Q9Y3P93I2D: score=1 
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process ----
    GO:0006886intracellular protein transport ----
    GO:0006897endocytosis ----
    GO:0006913nucleocytoplasmic transport ----
    GO:0007165signal transduction ----

    RAB34 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RAB34

    Search CenterWatch for drugs/clinical trials and news about RAB34

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RAB34 gene (8 alternative transcripts): 
    NM_001142624.2  NM_001142625.2  NM_001144942.1  NM_001144943.1  NM_001256276.1  NM_001256277.1  NM_001256278.1  NM_031934.5  

    Unigene Cluster for RAB34:

    RAB34, member RAS oncogene family
    Hs.301853  [show with all ESTs]
    Unigene Representative Sequence: NM_031934
    18/23 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):
    ENST00000395243 ENST00000453384 ENST00000301043(uc002hch.2 uc010wau.1)
    ENST00000450529 ENST00000415040 ENST00000484161 ENST00000422279 ENST00000395242
    ENST00000474704 ENST00000395245(uc002hce.2 uc002hcg.2) ENST00000436730
    ENST00000430132 ENST00000583538 ENST00000353676 ENST00000412625 ENST00000496866
    ENST00000419712 ENST00000481501
    miRNA
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    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate RAB34 (see all 29):
    hsa-miR-3910 hsa-miR-148b hsa-miR-128 hsa-miR-1271 hsa-miR-301a hsa-miR-124 hsa-miR-661 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidRAB34 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF322067.1 AF327350.1 AJ277106.1 AK027312.1 AK074689.1 AK297850.1 AK304633.1 BC016841.1 
    BC066904.1 BC091510.1 BT006702.1 

    24/29 DOTS entries (see all 29):

    DT.91691857  DT.92443118  DT.102843818  DT.95197976  DT.100829142  DT.92443115  DT.100031106  DT.95069403 
    DT.100031110  DT.95368709  DT.120910257  DT.100883974  DT.100883981  DT.100883979  DT.100883985  DT.120910258 
    DT.100883977  DT.100883978  DT.92443119  DT.99988328  DT.100883972  DT.100883983  DT.120910261  DT.120910274 

    24/476 AceView cDNA sequences (see all 476):

    AI123915 BQ877254 BP354410 BU526908 CB154567 BI768064 CA389945 AI573072 
    BC016841 CA431331 AW793261 BQ925081 BM728685 AL578543 BM982696 BQ012888 
    CA310126 AA906902 BU688067 CA418547 BM721861 AK027312 CA391582 CB125701 

    GeneLoc Exon Structure

    5/21 Alternative Splicing Database (ASD) splice patterns (SP) for RAB34 (see all 21)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g · 2h · 2i · 2j · 2k · 2l ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ·
    SP1:                          -     -     -     -     -     -     -     -                       -           -     -                             -               
    SP2:                                                                                            -           -     -                             -               
    SP3:                                                                                            -           -     -                             -               
    SP4:                                                                                            -           -     -                             -               
    SP5:                          -     -     -     -     -     -     -     -                       -           -     -                             -               

    ExUns: 8c ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c · 12d
    SP1:                                                            
    SP2:                                                            
    SP3:  -     -                                                   
    SP4:                    -     -     -     -                     
    SP5:                                                            


    ECgene alternative splicing isoforms for RAB34

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RAB34 expression in normal human tissues (normalized intensities)      RAB34 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTAGTCACTT
    RAB34 Expression
    About this image


    RAB34 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/25 selected tissues (see all 25) fully expand
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             colon ; peripheral nerve/ganglion   
     
     Uterus (Reproductive System)    fully expand to see all 3 entries
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Leydig Cells Testis Interstitium
             testis ; cells in seminiferus ducts   
     
     Thyroid (Endocrine System)    fully expand to see all 2 entries
             thyroid gland ; glandular cells   
     
     Intestine (Gastrointestinal Tract)    fully expand to see all 2 entries
             small intestine ; glandular cells   

    See RAB34 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RAB34

    SOURCE GeneReport for Unigene cluster: Hs.301853

    UniProtKB/Swiss-Prot: NARR_HUMAN, P0DI83
    Tissue specificity: Ubiquitously expressed (at protein level)


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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB34

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RAB34 gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rab341 , 5 RAB34, member of RAS oncogene family1, 5 89.19(n)1
    94.98(a)1
      11 (46.74 cM)5
    193761  NM_001159482.11  NP_001152954.11 
     781884305 
    chicken
    (Gallus gallus)
    Aves LOC1008588491 ras-related protein Rab-34-like 77.07(n)
    82.28(a)
      100858849  XM_003642428.1  XP_003642476.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.33652 Xenopus laevis transcribed sequence with moderate similarity more 76.68(n)    BJ627400.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rab34a1 RAB34, member RAS oncogene family a 71.71(n)
    75.97(a)
      450074  NM_001006094.1  NP_001006094.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG79803 small monomeric GTPase 52(a)   62A10   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YPT106
    YPT526
    Rab family GTP-binding protein that contains the P...
    Rab family GTPase, similar to Ypt51p and Ypt53p an...
    31(a)
    29(a)
    many ↔ many
    many ↔ many
    II(737770-738369)
    XI(465367-466071)


    ENSEMBL Gene Tree for RAB34 (if available)
    TreeFam Gene Tree for RAB34 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RAB34 gene
    RAB6C2  RAB6A2  RAB412  RAB362  RAB6B2  
    18/79 SIMAP similar genes for RAB34 using alignment to 12 protein entries:     NARR_HUMAN (see all proteins) (see all similar genes):
    RAB36    rab1b    RAB8B    RAB8A    RAB38    RAB10
    RAB13    DKFZp686J06205    RAB43    RAB19    RAB15    DKFZp686J07132
    RAB7A    RAB30    RAB11A    RAB3A    RAB1A    RAB1B

    RAB34 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/54 SNPs in RAB34 are shown (see all 54)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1913834751,2
    --27041015(+) AAAAAG/TAAAAA 8 -- ds50010--------
    rs795915051,2
    C,F--27041046(+) TTGGGT/CATAAG 8 -- ds50011Minor allele frequency- C:0.02NA 120
    rs1506099151,2
    --27041069(+) GGACAC/TGTGTG 8 -- ds50010--------
    rs728475431,2
    C--27041246(+) GGCCAC/TACAGT 8 -- ds50014Minor allele frequency- T:0.12WA NA EA 360
    rs152001,2
    C,H--27041369(+) CTCAAA/GCACAA 8 -- ut31 ese37Minor allele frequency- G:0.00MN NS EA NA 606
    rs151991,2
    C--27041415(+) TCTCCC/TTCACT 8 -- ut31 ese33Minor allele frequency- T:0.00MN NA 188
    rs1159350421,2
    C,F--27041488(+) CTGGGG/AGCAGG 8 -- ut311Minor allele frequency- A:0.03WA 118
    rs1837504901,2
    C--27041630(+) TAGGGA/CTGGGC 9 S I ut31 mis10--------
    rs1395256491,2
    C,F--27041829(+) AATGCG/ATCGAG 15 /R /C mis1 int11Minor allele frequency- A:0.00NA 4552
    rs1392197281,2
    C--27041907(+) TTCTCA/GGACAT 15 R * stg1 int10--------

    HapMap Linkage Disequilibrium report for RAB34 (27041299 - 27045447 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RAB34:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv908028CNV Loss21882294


    Human Gene Mutation Database (HGMD): RAB34
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610917    OMIM disorders: --

    8 diseases for RAB34:    About MalaCards
    histiocytosis    intrahepatic cholangiocarcinoma    kaposi's sarcoma    cholangiocarcinoma
    hyperglycemia    sarcoma    endotheliitis    tuberculosis


    RAB34 for disorders           About GeneDecksing


    Export disorders for RAB34 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RAB34 gene, integrated from 9 sources (see all 38):
    (articles sorted by number of sources associating them with RAB34)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A unique region of RILP distinguishes it from its related proteins in its regulation of lysosomal morphology and interaction with Rab7 and Rab34. (PubMed id 14668488)1, 2 Wang T.... Hong W. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Small GTPase Rah/Rab34 is associated with membrane ruffles and macropinosomes and promotes macropinosome formation. (PubMed id 12446704)1, 3 Sun P....Endo T. (2003)
    5. Rab39, a novel Golgi-associated Rab GTPase from human dendritic cells involved in cellular endocytosis. (PubMed id 12684051)1, 9 Chen T.... Cao X. (2003)
    6. Identification of risk loci with shared effects on fiv e major psychiatric disorders: a genome-wide analysis. (PubMed id 23453885)1  ....Sullivan P.F. (2013)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. Identification and characterization of a novel ubiquitous nucleolar protein 'NARR' encoded by a gene overlapping the rab34 oncogene. (PubMed id 21586586)1 Zougman A.... Wisniewski J.R. (2011)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 83871 HGNC: 16519 AceView: RAB34 Ensembl:ENSG00000109113 euGenes: HUgn83871
    ECgene: RAB34 H-InvDB: RAB34

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RAB34 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAB34 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RAB34 gene:
    Search GeneIP for patents involving RAB34

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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