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RAB34 Gene

protein-coding   GIFtS: 57

GC17M024065
RAB34, member RAS oncogene family
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
OTTHUMP00000163525 2
RAB39 1, 2, 3
RAH 1, 2, 3, 5
Rab-39 3
Descriptions
RAB34, member RAS oncogene family 2
Ras-related protein RAB34 2
Ras-related protein Rah 3
External Ids
HGNC: 165191
Entrez Gene: 838712
UniProtKB: Q9BZG13
Ensembl: ENSG000001091137
Search outside databases for aliases for RAB34 gene

Previous GC identifers: GC17M026887 GC17M028941 GC17M027186

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for RAB34:
RAB proteins, like RAB34, are small GTPases that regulate vesicle budding, docking, and fusion
along endocytosis and exocytosis pathways (Chen et al., 2003 [PubMed 12684051]).[supplied by OMIM]

UniProtKB/Swiss-Prot: RAB34_HUMAN, Q9BZG1
Function: Protein transport. Involved in the redistribution of lysosomes to the peri-Golgi region
(By similarity)

Gene Wiki entry for RAB34

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the RAB34 gene  

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q11.2   HGNC cytogenetic band: 17q11.2

RAB34 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M024065:     (about GC identifiers)

Start:
24,065,429 bp from pter
End:
24,069,328 bp from pter
Size:
3,900 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000017.9  NT_010799.14  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: RAB34_HUMAN, Q9BZG1 (See protein sequence)
Recommended Name: Ras-related protein Rab-34  
Size: 259 amino acids; 29044 Da
Subunit: Interacts with RILP
Subcellular location: Cytoplasm (By similarity). Golgi apparatus (By similarity). Note=Associates
with the Golgi complex (By similarity)
Secondary accessions: Q5BJE6 Q8NCJ8 Q96AR4
Alternative splicing: 2 isoforms:  Q9BZG1-1   Q9BZG1-2   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (5 alternative transcripts): 
    NP_001136096.2  NP_001136097.2  NP_001138414.1  NP_001138415.1  NP_114140.4  


    ENSEMBL proteins: 
    ENSP00000301043 ENSP00000378663 ENSP00000378664 ENSP00000226259 ENSP00000378666 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (Rab34)
    Human Recombinant Proteins from Abnova (RAB34)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737 cytoplasm IEA--
    GO:0005794 Golgi apparatus IEA--
    About this table

    Antibodies for RAB34: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for RAB34
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (Rab34), each with their AbpromiseSM
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for RAB34

    Assays for RAB34: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    4 InterPro domains/families:
     IPR001806 Ras_GTPase
     IPR005225 Small_GTP_bd
     IPR003579 GTPase_Rab
     IPR013753 Ras


       GeneDecks  RAB34 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q9BZG1

    ProtoNet protein and cluster: Q9BZG1

    1 Blocks protein family: IPB001806 Transforming protein P21 RAS signature

    UniProtKB/Swiss-Prot: RAB34_HUMAN, Q9BZG1
    Similarity: Belongs to the small GTPase superfamily. Rab family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (RAB34)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 7): NR_024575

                  Applied Biosystems Silencer® siRNAs for RAB34

                  Sigma-Aldrich siRNA for RAB34  
                         Sigma-Aldrich shRNA for RAB34  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for RAB34
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 5): NM_001142624
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): NM_001142624
                                     untagged cDNA clones in CMV expression vector (see all 5): NM_001142624 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001144943

    UniProtKB/Swiss-Prot: RAB34_HUMAN, Q9BZG1
    Function: Protein transport. Involved in the redistribution of lysosomes to the peri-Golgi region
    (By similarity)

    1 MGI phenotypic allele for Rab34 (no phenotypes)


    2 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0005525 GTP binding IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    1 Sigma-Aldrich "Your Favorite Gene" Pathway for  RAB34  (Your Favorite Gene powered by Ingenuity) 
     Macropinocytosis

       GeneDecks  RAB34 for the pathways selected above  
    About GeneDecksing

     Gene Network CentralTM Interacting Genes and Proteins Network for  RAB34 


    3 Interacting proteins for RAB34 (ENSP000003010433) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UNC13BENSP000003677573STRING (score=.878)
    RILPENSP000003013363STRING (score=.857)
    WASF2ENSP000003631313STRING (score=.737)
    About this table

    2 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007264 small GTPase mediated signal transduction IEA--
    GO:0015031 protein transport IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Enzo Life Sciences drugs & compounds for RAB34
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for RAB34

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (RAB34)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 7): NR_024575

                  Sigma-Aldrich siRNA for RAB34  
                         Sigma-Aldrich shRNA for RAB34  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001142624  NM_001142625  NM_031934  

    REFSEQ mRNAs for RAB34 gene (5 alternative transcripts): 

    NM_001142624.2   NM_001142625.2   NM_001144942.1   NM_001144943.1   NM_031934.5   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001142624  NM_001142625  NM_031934  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 5): NM_001142624
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): NM_001142624
                                     untagged cDNA clones in CMV expression vector (see all 5): NM_001142624 

    Additional cDNA sequence: 

    AF322067.1 AF327350.1 AJ277106.1 AK027312.1 AK074689.1 AK297850.1 AK304633.1 BC016841.1 
    BC066904.1 BC091510.1 BT006702.1 CR596043.1 CR600820.1 CR612137.1 CR612854.1 CR613380.1 
    CR614283.1 CR620011.1 CR622817.1 

    24/29 DOTS entries (see all 29 ):

    DT.92443118  DT.91691857  DT.102843818  DT.95197976  DT.100829142  DT.92443115  DT.100031106  DT.95069403 
    DT.100031110  DT.95368709  DT.120910257  DT.100883974  DT.100883981  DT.100883979  DT.100883985  DT.120910258 
    DT.100883977  DT.100883978  DT.92443119  DT.99988328  DT.100883972  DT.100883983  DT.120910261  DT.120910274 

    24/476 AceView cDNA sequences (see all 476 ):

    BP354410 CR622817 BM705481 BM459933 BQ674626 AW793261 BU686336 AK027312 
    CD518942 BU175922 BC016841 BU526908 AW769494 BU856687 AI082082 BM767908 
    AA991593 CF127918 BQ218224 CB125701 CF126767 AK074689 BU688067 BI768064 

    highest scoring ESTs for RAB34:

    AF327350 AI189282 AI205145 AJ277106 AK027312 AK074689 AL547914 AL550699 AL556234 AL564667 

    Unigene Cluster for RAB34:

    RAB34, member RAS oncogene family
    Hs.301853  [show with all ESTs]
    Unigene Representative Sequence: NM_031934


    GeneLoc Exon Structure

    5/21 Alternative Splicing Database (ASD) splice patterns (SP) for RAB34 (see all 21 )

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g · 2h · 2i · 2j · 2k · 2l ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ·
    SP1:                          -     -     -     -     -     -     -     -                       -           -     -                             -               
    SP2:                                                                                            -           -     -                             -               
    SP3:                                                                                            -           -     -                             -               
    SP4:                                                                                            -           -     -                             -               
    SP5:                          -     -     -     -     -     -     -     -                       -           -     -                             -               

    ExUns: 8c ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c · 12d
    SP1:                                                            
    SP2:                                                            
    SP3:  -     -                                                   
    SP4:                    -     -     -     -                     
    SP5:                                                            

    About this scheme

    ECgene alternative splicing isoforms for RAB34

    5 Ensembl transcripts including schematic representations:
    ENST00000301043  ENST00000395242  ENST00000395243  ENST00000353676  ENST00000395245  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    RAB34 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for RAB34

    1 / 2 / 3

    4 probe-sets matching RAB34 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    45269_at2, 3 U95-B 1 1.00 1.00 1.00 1.00 AI189282 0.80 1.00 0.91 1

    224710_at2, 3 U133-B 1 1.00 1.00 -- -- AF322067 0.60 1.00 0.82 1

    224710_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    1555630_a_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  RAB34 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: CTAGTCACTT

    SOURCE GeneReport for Unigene cluster: Hs.301853
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for RAB34 gene from 5/10 species (see all 10 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    RAB341   -- RAB34, member RAS oncogene family 92.66(n)
    97.3(a)
    612952  XM_849054.1  XP_854147.1 
    chimpanzee
    (Pan troglodytes)
    RAB341   -- RAB34, member RAS oncogene family 99.49(n)
    99.61(a)
    454531  XM_511360.2  XP_511360.2 
    cow
    (Bos taurus)
    RAB341   -- RAB34, member RAS oncogene family 90.85(n)
    95.59(a)
    282028  NM_001033612.1  NP_001028784.1 
    rat
    (Rattus norvegicus)
    Rab341   -- RAB34, member RAS oncogene family 89.19(n)
    94.21(a)
    360571  NM_001012140.1  NP_001012140.1 
    mouse
    (Mus musculus)
    Rab341, 5 11 (44.89 cM)5
    RAB34, member of RAS oncogene family1, 5 89.06(n)1
    94.59(a)1
    193761  NM_033475.21  NP_258436.21 
     AA0417805  AB0829275  (see all 31)
    About this table        Species with no ortholog for RAB34

    ENSEMBL Gene Tree for RAB34
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for RAB34 gene
    RAB362  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/19 NCBI SNPs in RAB34 are shown (see all 19 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 18)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 17 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs152001,2
    C,H24065496(+) CTCAAA/GCACAA 4 -- ut31 ese35Minor allele frequency- G:0.00MN EU EA WA 602
    rs115457001,2
    C,F24068609(-) GCCCCG/TGGTGA 1 -- ut51 ese33Minor allele frequency- T:0.05NA 128
    rs121251,2
    F24066192(+) TGAGAC/GTGCCC 3 V/L mis13Minor allele frequency- G:0.04NA EA 251
    rs151991,2
    C24065542(+) TCTCCC/TTCACT 4 -- ut31 ese31Minor allele frequency- T:0.00MN 184
    rs44293421,2
    H24066183(+) AGTGAG/AAGATG 3 F/L mis1 ese34Minor allele frequency- A:0.00EU EA WA 406
    rs115456991,2
    C,F,H24068131(-) CTGAGG/AAAGGA 4 R/R syn16Minor allele frequency- A:0.02MN EU EA WA NA 660
    rs80691351,2
    C,F,H24066992(+) ATCTCG/AAAGTC 4 F/F syn15Minor allele frequency- A:0.00EU EA WA NA 480
    --
    rs129526231,2
    --24068679(+) AGACTA/CTTCGG 1 -- ut51 ese30--------
    --
    rs115457011,2
    --24068670(+) GGGGCA/GAGGAG 1 -- ut51 ese30--------
    --
    rs716696471,2
    --24065746(+) GCACA-/GTGCCCT 4 A/ fra1 ut310--------
    About this table

    HapMap Linkage Disequilibrium images for RAB34 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 610917

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/19 PubMed articles for RAB34 gene (see all 19 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 83871 HGNC: 16519 AceView: RAB34 Ensembl:ENSG00000109113 euGenes: HUgn83871
    ECgene: RAB34 H-InvDB: RAB34
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for RAB34 Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for RAB34:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
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      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for RAB34-related products

     Millipore Custom Antibody & Bulk Services
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     Predesigned and custom siRNAs for RAB34 Antibodies for RAB34
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
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