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Aliases for RAB34 Gene

Aliases for RAB34 Gene

  • RAB34, Member RAS Oncogene Family 2 3
  • RAH 3 4 6
  • Ras-Related Protein Rab-39 3 4
  • Ras-Related Protein Rah 3 4
  • RAB39 3 4
  • Nine Amino-Acid Residue-Repeats 4
  • Ras-Related Protein Rab-34 3
  • NARR 4

External Ids for RAB34 Gene

Summaries for RAB34 Gene

Entrez Gene Summary for RAB34 Gene

  • This gene encodes a protein belonging to the RAB family of proteins, which are small GTPases involved in protein transport. This family member is a Golgi-bound member of the secretory pathway that is involved in the repositioning of lysosomes and the activation of macropinocytosis. Alternative splicing of this gene results in multiple transcript variants. This gene overlaps and shares exon structure with the nine-amino acid residue-repeats (NARR) gene, which encodes a functionally distinct nucleolar protein from a different reading frame. [provided by RefSeq, Jan 2012]

GeneCards Summary for RAB34 Gene

RAB34 (RAB34, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include GTP binding. An important paralog of this gene is RAB41.

UniProtKB/Swiss-Prot for RAB34 Gene

  • Protein transport. Involved in the redistribution of lysosomes to the peri-Golgi region (By similarity). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes.

Gene Wiki entry for RAB34 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB34 Gene

Genomics for RAB34 Gene

Genomic Location for RAB34 Gene

Start:
28,714,281 bp from pter
End:
28,718,429 bp from pter
Size:
4,149 bases
Orientation:
Minus strand

Genomic View for RAB34 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAB34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB34 Gene

Regulatory Elements for RAB34 Gene

Proteins for RAB34 Gene

  • Protein details for RAB34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DI83-NARR_HUMAN
    Recommended name:
    Ras-related protein Rab-34, isoform NARR
    Protein Accession:
    P0DI83
    Secondary Accessions:

    Protein attributes for RAB34 Gene

    Size:
    198 amino acids
    Molecular mass:
    21118 Da
    Quaternary structure:
    • May interact with EIF5A and ERF1

    Alternative splice isoforms for RAB34 Gene

    UniProtKB/Swiss-Prot:
  • Protein details for RAB34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZG1-RAB34_HUMAN
    Recommended name:
    Ras-related protein Rab-34
    Protein Accession:
    Q9BZG1
    Secondary Accessions:
    • B4E3A0
    • E9PEJ9
    • Q5BJE6
    • Q8NCJ8
    • Q96AR4

    Protein attributes for RAB34 Gene

    Size:
    259 amino acids
    Molecular mass:
    29044 Da
    Quaternary structure:
    • Interacts with RILP.

    Alternative splice isoforms for RAB34 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAB34 Gene

Proteomics data for RAB34 Gene at MOPED

Post-translational modifications for RAB34 Gene

No data available for DME Specific Peptides for RAB34 Gene

Domains for RAB34 Gene

Gene Families for RAB34 Gene

HGNC:
  • RAB :RAB, member RAS oncogene

Protein Domains for RAB34 Gene

UniProtKB/Swiss-Prot:

RAB34_HUMAN
Family:
  • Belongs to the small GTPase superfamily. Rab family.:
    • Q9BZG1
genes like me logo Genes that share domains with RAB34: view

Function for RAB34 Gene

Molecular function for RAB34 Gene

UniProtKB/Swiss-Prot Function: Protein transport. Involved in the redistribution of lysosomes to the peri-Golgi region (By similarity). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes.

Gene Ontology (GO) - Molecular Function for RAB34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IBA --
GO:0005515 protein binding IPI 16138900
GO:0005525 GTP binding IEA --
GO:0017160 Ral GTPase binding IPI 24056301
GO:0019001 guanyl nucleotide binding --
genes like me logo Genes that share ontologies with RAB34: view

Phenotypes for RAB34 Gene

GenomeRNAi human phenotypes for RAB34:
genes like me logo Genes that share phenotypes with RAB34: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RAB34 Gene

Localization for RAB34 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB34 Gene

Nucleus. Nucleus, nucleolus. Note=Colocalizes with rDNA clusters.
Cytoplasm. Golgi apparatus. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB34 Gene COMPARTMENTS Subcellular localization image for RAB34 gene
Compartment Confidence
cytosol 3
endosome 2
golgi apparatus 2
lysosome 2
nucleus 2
vacuole 2
extracellular 1

Gene Ontology (GO) - Cellular Components for RAB34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle --
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005737 cytoplasm --
GO:0005769 early endosome --
genes like me logo Genes that share ontologies with RAB34: view

Pathways for RAB34 Gene

genes like me logo Genes that share pathways with RAB34: view

Pathways by source for RAB34 Gene

1 Qiagen pathway for RAB34 Gene

Interacting Proteins for RAB34 Gene

Selected Interacting proteins: Q9BZG1-RAB34_HUMAN for RAB34 Gene via I2D

Gene Ontology (GO) - Biological Process for RAB34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport --
GO:0006897 endocytosis --
GO:0006913 nucleocytoplasmic transport --
GO:0007165 signal transduction --
genes like me logo Genes that share ontologies with RAB34: view

Transcripts for RAB34 Gene

Unigene Clusters for RAB34 Gene

RAB34, member RAS oncogene family:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAB34 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g · 2h · 2i · 2j · 2k · 2l ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ·
SP1: - - - - - - - - - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - -
SP5: - - - - - - - - - - - -
SP6: - - - - -
SP7: - - - -
SP8: - - - - - - - -
SP9: - - - - - - - - - - - -
SP10: - - - - - -
SP11: - - - - -
SP12: - - - - - - - - - - - - - - - -
SP13: - - - - - - - - - - - -
SP14: - - - - - -
SP15: - -
SP16: - - - -
SP17: - - -
SP18: - - - - - - - - -
SP19:
SP20:
SP21: - - - - - - - -

ExUns: 8c ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c · 12d
SP1:
SP2:
SP3: - -
SP4: - - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:

Relevant External Links for RAB34 Gene

GeneLoc Exon Structure for
RAB34
ECgene alternative splicing isoforms for
RAB34

Expression for RAB34 Gene

mRNA expression in normal human tissues for RAB34 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for RAB34 Gene

SOURCE GeneReport for Unigene cluster for RAB34 Gene Hs.301853

genes like me logo Genes that share expressions with RAB34: view

Orthologs for RAB34 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAB34 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB34 36
  • 99.68 (n)
  • 100 (a)
RAB34 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RAB34 36
  • 91.01 (n)
  • 96.08 (a)
RAB34 37
  • 66 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAB34 36
  • 92.79 (n)
  • 97.68 (a)
RAB34 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rab34 36
  • 89.19 (n)
  • 94.98 (a)
Rab34 16
Rab34 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAB34 37
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAB34 37
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rab34 36
  • 89.32 (n)
  • 94.59 (a)
chicken
(Gallus gallus)
Aves LOC100858849 36
  • 77.17 (n)
  • 82.35 (a)
RAB34 37
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3365 36
tropical clawed frog
(Silurana tropicalis)
Amphibia rab34 36
  • 74.94 (n)
  • 81.4 (a)
Str.2247 36
zebrafish
(Danio rerio)
Actinopterygii rab34a 36
  • 71.71 (n)
  • 75.97 (a)
rab34a 37
  • 75 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta RabX5 37
  • 38 (a)
OneToMany
CG7980 38
  • 52 (a)
worm
(Caenorhabditis elegans)
Secernentea C56E6.2 37
  • 22 (a)
ManyToMany
Y71H2AM.12 37
  • 31 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPT6 37
  • 30 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.67 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 49 (a)
OneToMany
Species with no ortholog for RAB34:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB34 Gene

ENSEMBL:
Gene Tree for RAB34 (if available)
TreeFam:
Gene Tree for RAB34 (if available)

Paralogs for RAB34 Gene

Paralogs for RAB34 Gene

genes like me logo Genes that share paralogs with RAB34: view

Variants for RAB34 Gene

Sequence variations from dbSNP and Humsavar for RAB34 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs12125 - 28,715,047(+) TGAGA(C/G)TGCCC missense, reference, intron-variant
rs15199 -- 28,714,397(+) TCTCC(C/T)TCACT utr-variant-3-prime
rs15200 -- 28,714,351(+) CTCAA(A/G)CACAA utr-variant-3-prime
rs3208128 -- 28,714,472(-) TTCCT(C/G)CCCCC utr-variant-3-prime
rs4429342 -- 28,715,038(+) AGTGA(A/G)AGATG reference, missense, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB34 Gene

Variant ID Type Subtype PubMed ID
nsv908028 CNV Loss 21882294

Relevant External Links for RAB34 Gene

HapMap Linkage Disequilibrium report
RAB34
Human Gene Mutation Database (HGMD)
RAB34

Disorders for RAB34 Gene

No disorders were found for RAB34 Gene.

No data available for UniProtKB/Swiss-Prot for RAB34 Gene

Publications for RAB34 Gene

  1. A unique region of RILP distinguishes it from its related proteins in its regulation of lysosomal morphology and interaction with Rab7 and Rab34. (PMID: 14668488) Wang T. … Hong W. (Mol. Biol. Cell 2004) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes. (PMID: 21255211) Seto S. … Koide Y. (Traffic 2011) 3 4
  5. Rab39, a novel Golgi-associated Rab GTPase from human dendritic cells involved in cellular endocytosis. (PMID: 12684051) Chen T. … Cao X. (Biochem. Biophys. Res. Commun. 2003) 3 23

Products for RAB34 Gene

Sources for RAB34 Gene

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