Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RAB33B Gene

protein-coding   GIFtS: 53
GCID: GC04P140374

RAB33B, member RAS oncogene family
 Explore 3 diseases affiliated with
RAB33B via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RAB33B    

Aliases
for RAB33B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
RAB33B, Member RAS Oncogene Family1 2
DKFZP434G0991
Ras-Related Protein Rab-33B2

External Ids:    HGNC: 160751   Entrez Gene: 834522   Ensembl: ENSG000001720077   OMIM: 6059505   UniProtKB: Q9H0823   

Export aliases for RAB33B gene to outside databases

Previous GC identifers: GC04P141280 GC04P140674 GC04P140841 GC04P140952 GC04P140732 GC04P136104


Summaries
for RAB33B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RAB33B:
Small GTP-binding proteins of the RAB family, such as RAB33B, play important roles at defined steps of vesicular
transport in protein secretion and the endocytosis pathway (Zheng et al., 1998 (PubMed 9512502)).(supplied by OMIM,
Feb 2010)

UniProtKB/Swiss-Prot: RB33B_HUMAN, Q9H082
Function: Protein transport. Acts, in coordination with RAB6A, to regulate intra-Golgi retrograde trafficking. It is
involved in autophagy, acting as a modulator of autophagosome formation

Gene Wiki entry for RAB33B


Genomic Views
for RAB33B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RAB33B gene promoter:
         STAT1   Sp1   p53   FOXD1   STAT1beta   Egr-4   STAT1alpha   E47   STAT3   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RAB33B promoter sequence
   Search SABiosciences Chromatin IP Primers for RAB33B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB33B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q28   Ensembl cytogenetic band:  4q31.1   HGNC cytogenetic band: 4q28

RAB33B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAB33B gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P140374:  view genomic region     (about GC identifiers)

Start:
 140,374,386 bp from pter      End:
 140,397,763 bp from pter
Size:
 23,378 bases      Orientation:
 plus strand

Proteins
for RAB33B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RB33B_HUMAN, Q9H082 (See protein sequence)
Recommended Name: Ras-related protein Rab-33B  
Size: 229 amino acids; 25718 Da
Subunit: Interacts with ATG16L; the interaction is important for autophagosome formation (By similarity)
Subcellular location: Golgi apparatus membrane; Lipid-anchor (By similarity). Golgi apparatus, cis-Golgi network
Secondary accessions: B2R987 Q4W5B0

Explore the universe of human proteins at neXtProt for RAB33B: NX_Q9H082

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H082

    • RAB33B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_112586.1  
    ENSEMBL proteins: 
     ENSP00000306496  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: RAB33B
    OriGene Custom Protein Services for RAB33B 
    GenScript Custom Purified and Recombinant Proteins Services for RAB33B
    Novus Biologicals RAB33B Proteins
    Novus Biologicals RAB33B Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RAB33B

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005794Golgi apparatus IDA--
    GO:0005796Golgi lumen IDA18448665


    RAB33B for ontologies           About GeneDecksing



    RAB33B Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for RAB33B 
    GenScript Custom Superior Antibodies Services for RAB33B
    Novus Biologicals RAB33B Antibodies
    Search for Antibodies for RAB33B at Abcam  
    Uscn Antibodies for RAB33B
    Search ThermoFisher Antibodies for RAB33B

    Assay Products for RAB33B: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RAB33B
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for RAB33B

    Protein Domains /
    Families
    for RAB33B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RAB33B for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR003579 Small_GTPase_Rab_type

    Graphical View of Domain Structure for InterPro Entry Q9H082

    ProtoNet protein and cluster: Q9H082

    1 Blocks protein family: IPB001806 Transforming protein P21 RAS signature

    UniProtKB/Swiss-Prot: RB33B_HUMAN, Q9H082
    Similarity: Belongs to the small GTPase superfamily. Rab family


    Function
    for RAB33B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RB33B_HUMAN, Q9H082
    Function: Protein transport. Acts, in coordination with RAB6A, to regulate intra-Golgi retrograde trafficking. It is
    involved in autophagy, acting as a modulator of autophagosome formation

    miRNA
    Products:            		 OriGene 3'-UTR Clone: RAB33B
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAB33B
    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate RAB33B (see all 26):
    hsa-miR-623 hsa-miR-520d-5p hsa-miR-128 hsa-miR-944 hsa-miR-340 hsa-miR-548l hsa-miR-9 hsa-miR-499-5p
    SwitchGear 3'UTR luciferase reporter plasmid: RAB33B 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAB33B (see all 7)
    OriGene shRNA RFP: RAB33B
    OriGene siRNA: RAB33B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAB33B

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for RAB33B

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAB33B (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAB33B
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: RAB33B (NM_031296)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAB33B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB33B 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for RAB33B
    Search LifeMap BioReagents cell lines for RAB33B

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB33B

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005525GTP binding IEA--


    RAB33B for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for RAB33B:
     Synthetic lethal with Ras 


    Pathways & Interactions
    for RAB33B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Sertoli-Sertoli Cell Junction Dynamics
    		Epithelial Tight Junctions0.36

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RAB33B
        Epithelial Tight Junctions


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RAB33B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/14 Interacting proteins for RAB33B (Q9H0823 ENSP000003064964) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACVR1Q047713, ENSP000002636404I2D: score=3 STRING: ENSP00000263640
    GABARAPL1Q9H0R83, ENSP000002664584I2D: score=1 STRING: ENSP00000266458
    RABGEF1Q9UJ413, ENSP000002849574I2D: score=1 STRING: ENSP00000284957
    GOLGA2Q083793, ENSP000004160974I2D: score=2 STRING: ENSP00000416097
    RABEP1Q152763, ENSP000002624774I2D: score=2 STRING: ENSP00000262477
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006914autophagy IEA--
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0015031protein transport IEA--
    GO:2000156regulation of retrograde vesicle-mediated transport, Golgi to ER IMP--
    GO:2000785regulation of autophagic vacuole assembly ISS--


    RAB33B for ontologies           About GeneDecksing



    Drugs & Compounds
    for RAB33B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RAB33B
    Search CenterWatch for drugs/clinical trials and news about RAB33B / RB33B 

    Transcripts
    for RAB33B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RAB33B gene: 
    NM_031296.1  

    Unigene Cluster for RAB33B:

    RAB33B, member RAS oncogene family
    Hs.591679  [show with all ESTs]
    Unigene Representative Sequence: AL136904
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000507271 ENST00000305626(uc003ihv.3)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: RAB33B
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAB33B
    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate RAB33B (see all 26):
    hsa-miR-623 hsa-miR-520d-5p hsa-miR-128 hsa-miR-944 hsa-miR-340 hsa-miR-548l hsa-miR-9 hsa-miR-499-5p
    SwitchGear 3'UTR luciferase reporter plasmid: RAB33B 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAB33B (see all 7)
    OriGene shRNA RFP: RAB33B
    OriGene siRNA: RAB33B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAB33B
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAB33B (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAB33B
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: RAB33B (NM_031296)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAB33B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB33B 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAB33B
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RAB33B
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAB33B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAB33B

    Additional cDNA sequence: 

    AF350420.1 AK313685.1 AL136904.1 BC036064.1 BC111977.1 

    3 DOTS entries:

    DT.97838286  DT.75100804  DT.70101003 

    24/50 AceView cDNA sequences (see all 50):

    Z36966 BM675710 CK823289 BM931688 AI889871 AL136904 CF994555 AU280090 
    AA577079 BQ723710 BM893637 NM_031296 BU754295 BM893798 T30461 BX505064 
    BF194896 CD655405 BC036064 CK823290 BM967095 AI554525 D61789 BM966968 

    GeneLoc Exon Structure


    Expression
    for RAB33B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RAB33B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAGTTCAATA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    RAB33B expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ progenitor E69 (Embryonic Progenitor Cell)
    PureStem™ progenitor T36 (Embryonic Progenitor Cell)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See RAB33B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RAB33B

    SOURCE GeneReport for Unigene cluster: Hs.591679
        SABiosciences Custom PCR Arrays for RAB33B
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAB33B
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RAB33B
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAB33B
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAB33B
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB33B

    Orthologs
    for RAB33B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for RAB33B gene from 6/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Rab33b1 , 5 RAB33B, member of RAS oncogene family1, 5 87.48(n)1
    94.76(a)1    		   3 (22.49 cM)5
    193381  NM_016858.21  NP_058554.11 
     514839665 
    chicken
    (Gallus gallus)    		 Aves RAB33B1 RAB33B, member RAS oncogene family 82.23(n)
    92.51(a)    		   422441  NM_001008466.1  NP_001008466.1 
    lizard
    (Anolis carolinensis)    		 Reptilia RAB33B6
    		 --
    		 90(a)
    		 1 ↔ 1
    		 5(120263718-120268239)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BC059345.12   -- 76.79(n)    BC059345.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.111302 Transcribed sequence with weak similarity to protein more 72.59(n)    BI883463.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea rab-331 Protein RAB-33 58.71(n)
    60.8(a)    		   176470  NM_066913.2  NP_499314.1 


    ENSEMBL Gene Tree for RAB33B (if available)
    TreeFam Gene Tree for RAB33B (if available) 

    Paralogs
    for RAB33B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RAB33B gene
    RAB33A2  
    18/83 SIMAP similar genes for RAB33B using alignment to 2 protein entries:     RB33B_HUMAN (see all proteins) (see all similar genes):
    RAB33A    DKFZp686J06205    DKFZp686J07132    RAB19    RAB30    RAB4B
    RANP1    RAB43    RAB8B    rab1b    RAB15    RAB10
    RAB4A    RAB8A    RAB11B    KRAS    RAB11A    RAB17

    RAB33B for paralogs           About GeneDecksing



    Genomic Variants
    for RAB33B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for RAB33B
         1 CNV: 4418
    Human Gene Mutation Database (HGMD): RAB33B
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAB33B
    DNA2.0 Custom Variant and Variant Library Synthesis for RAB33B

    Disorders / Diseases
    for RAB33B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RAB33B for disorders           About GeneDecksing

    OMIM gene information: 605950    OMIM disorders: --

    UniProtKB/Swiss-Prot: RB33B_HUMAN, Q9H082
  • Defects in RAB33B are a cause of Smith-McCort dysplasia (SMC) [MIM:607326]. A rare autosomal recessive
    • osteochondrodysplasia with skeletal features identical to those of Dyggve-Melchior-Clausen syndrome, but with normal
    intelligence and no microcephaly. SMC is characterized by short limbs and trunk with barrel-shaped chest. The
    radiographic phenotype includes platyspondyly, generalized abnormalities of the epiphyses and metaphyses, and a
    distinctive lacy appearance of the iliac crest

    3 diseases for RAB33B:    About MalaCards
    transient cerebral ischemia    ischemia    cerebritis

    2 diseases from the University of Copenhagen DISEASES database for RAB33B:
    Sponastrime dysplasia     Spondyloepimetaphyseal dysplasia

    Export disorders for RAB33B gene to outside databases

    Publications
    for RAB33B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RAB33B gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with RAB33B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutation in RAB33B, which encodes a regulator of retrograde Golgi transport, defines a second Dyggve--Melchior--Clausen locus. (PubMed id 22652534)1, 2 Alshammari M.J.... Alkuraya F.S. (2012)
    2. Golgi-resident small GTPase Rab33B interacts with Atg16L and modulates autophagosome formation. (PubMed id 18448665)1, 2 Itoh T....Fukuda M. (2008)
    3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    6. A novel RAB33B mutation in Smith-McCort dysplasia. (PubMed id 23042644)2 Dupuis N.... Ghouzzi V.E. (2013)
    7. Ric1-Rgp1 complex is a guanine nucleotide exchange fac tor for the late Golgi Rab6A GTPase and an effector of the medial Golgi Rab33B G TPase. (PubMed id 23091056)1 Pusapati G.V....Pfeffer S.R. (2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. Integrative analysis of the ubiquitin proteome isolat ed using Tandem Ubiquitin Binding Entities (TUBEs). (PubMed id 22178446)1 Lopitz-Otsoa F....Rodriguez M.S. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

    External Searches for RAB33B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing RAB33B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 83452 HGNC: 16075 AceView: RAB33B Ensembl:ENSG00000172007 euGenes: HUgn83452
    ECgene: RAB33B H-InvDB: RAB33B

    Other Databases showing RAB33B gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RAB33B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RAB33B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAB33B Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for RAB33B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RAB33B gene:
    Search GeneIP for patents involving RAB33B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for RAB33B gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for RAB33B  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAB33B   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAB33B  
     OriGene Protein Over-expression Lysate for RAB33B   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for RAB33B   OriGene 3'-UTR Clone for RAB33B  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAB33B   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAB33B  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RAB33B   OriGene Custom Protein Services for RAB33B  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RAB33B
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAB33B
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB33B
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAB33B
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAB33B
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAB33B
     GenScript Custom Purified and Recombinant Proteins Services for RAB33B GenScript cDNA clones with any tag delivered in your preferred vector for RAB33B
     GenScript Custom Assay Services for RAB33B GenScript Custom Superior Antibodies Services for RAB33B
     GenScript Custom overexpressing Cell Line Services for RAB33B CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in RAB33B promoter
     Search Chromatin IP Primers for RAB33B
     RT2 qPCR Primer Assay in human, mouse, rat RAB33B
     Search GNC Networks for RAB33B
     SABiosciences PCR Arrays including human, mouse, rat RAB33B
     Search Tocris compounds for RAB33B
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     RAB33B antibodies
     RAB33B proteins
     RAB33B lysates
     Search for Antibodies for RAB33B at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for RAB33B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     RAB33B Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for RAB33B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB33B
     SwitchGear 3'UTR luciferase reporter plasmids for RAB33B
     SwitchGear Promoter luciferase reporter plasmids for RAB33B
     Search ThermoFisher Antibodies for RAB33B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB33B
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      RAB33B gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4