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Aliases for RAB33B Gene

Aliases for RAB33B Gene

  • RAB33B, Member RAS Oncogene Family 2 3
  • SMC2 3 6
  • Ras-Related Protein Rab-33B 3

External Ids for RAB33B Gene

Previous GeneCards Identifiers for RAB33B Gene

  • GC04P141280
  • GC04P140674
  • GC04P140841
  • GC04P140952
  • GC04P140732
  • GC04P140374
  • GC04P136104

Summaries for RAB33B Gene

Entrez Gene Summary for RAB33B Gene

  • Small GTP-binding proteins of the RAB family, such as RAB33B, play important roles at defined steps of vesicular transport in protein secretion and the endocytosis pathway (Zheng et al., 1998 [PubMed 9512502]).[supplied by OMIM, Feb 2010]

GeneCards Summary for RAB33B Gene

RAB33B (RAB33B, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB33B include smith-mccort dysplasia 2 and smith-mccort dysplasia. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include GTP binding. An important paralog of this gene is RAB33A.

UniProtKB/Swiss-Prot for RAB33B Gene

  • Protein transport. Acts, in coordination with RAB6A, to regulate intra-Golgi retrograde trafficking. It is involved in autophagy, acting as a modulator of autophagosome formation.

Gene Wiki entry for RAB33B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB33B Gene

Genomics for RAB33B Gene

Regulatory Elements for RAB33B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RAB33B Gene

139,453,232 bp from pter
139,476,609 bp from pter
23,378 bases
Plus strand

Genomic View for RAB33B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAB33B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB33B Gene

Proteins for RAB33B Gene

  • Protein details for RAB33B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras-related protein Rab-33B
    Protein Accession:
    Secondary Accessions:
    • B2R987
    • Q4W5B0

    Protein attributes for RAB33B Gene

    229 amino acids
    Molecular mass:
    25718 Da
    Quaternary structure:
    • Interacts with ATG16L; the interaction is important for autophagosome formation (By similarity). Interacts with RIC1 (via C-terminus domain); the interaction is direct with a preference for RAB33B-GTP. Interacts with RGP1.

neXtProt entry for RAB33B Gene

Proteomics data for RAB33B Gene at MOPED

Post-translational modifications for RAB33B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB33B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RAB33B Gene

Domains for RAB33B Gene

Gene Families for RAB33B Gene

  • RAB :RAB, member RAS oncogene

Suggested Antigen Peptide Sequences for RAB33B Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9H082
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB33B: view

Function for RAB33B Gene

Molecular function for RAB33B Gene

UniProtKB/Swiss-Prot Function: Protein transport. Acts, in coordination with RAB6A, to regulate intra-Golgi retrograde trafficking. It is involved in autophagy, acting as a modulator of autophagosome formation.

Gene Ontology (GO) - Molecular Function for RAB33B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IMP 21808068
GO:0005515 protein binding IPI 21808068
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RAB33B: view

Phenotypes for RAB33B Gene

GenomeRNAi human phenotypes for RAB33B:
genes like me logo Genes that share phenotypes with RAB33B: view

Animal Model Products

CRISPR Products

miRNA for RAB33B Gene

miRTarBase miRNAs that target RAB33B

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAB33B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RAB33B Gene

Localization for RAB33B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB33B Gene

Golgi apparatus membrane; Lipid-anchor. Golgi apparatus, cis-Golgi network.

Subcellular locations from

Jensen Localization Image for RAB33B Gene COMPARTMENTS Subcellular localization image for RAB33B gene
Compartment Confidence
golgi apparatus 5
cytosol 3
cytoskeleton 1
endosome 1
extracellular 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for RAB33B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005737 cytoplasm --
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with RAB33B: view

Pathways for RAB33B Gene

genes like me logo Genes that share pathways with RAB33B: view

Pathways by source for RAB33B Gene

1 Qiagen pathway for RAB33B Gene
3 Cell Signaling Technology pathways for RAB33B Gene
2 BioSystems pathways for RAB33B Gene
1 GeneGo (Thomson Reuters) pathway for RAB33B Gene

Gene Ontology (GO) - Biological Process for RAB33B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000042 protein targeting to Golgi IMP 20163571
GO:0001558 NOT regulation of cell growth IMP 20163571
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport --
GO:0006891 intra-Golgi vesicle-mediated transport IMP 20163571
genes like me logo Genes that share ontologies with RAB33B: view

Transcripts for RAB33B Gene

mRNA/cDNA for RAB33B Gene

Unigene Clusters for RAB33B Gene

RAB33B, member RAS oncogene family:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAB33B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB33B Gene

No ASD Table

Relevant External Links for RAB33B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RAB33B Gene

mRNA expression in normal human tissues for RAB33B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB33B Gene

SOURCE GeneReport for Unigene cluster for RAB33B Gene Hs.591679

genes like me logo Genes that share expressions with RAB33B: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RAB33B Gene

Orthologs for RAB33B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAB33B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RAB33B 35
  • 99.85 (n)
  • 99.56 (a)
RAB33B 36
  • 100 (a)
(Bos Taurus)
Mammalia RAB33B 35
  • 92.72 (n)
  • 96.94 (a)
RAB33B 36
  • 97 (a)
(Canis familiaris)
Mammalia RAB33B 35
  • 93.76 (n)
  • 98.4 (a)
RAB33B 36
  • 99 (a)
(Mus musculus)
Mammalia Rab33b 35
  • 87.48 (n)
  • 94.76 (a)
Rab33b 16
Rab33b 36
  • 95 (a)
(Monodelphis domestica)
Mammalia RAB33B 36
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia RAB33B 36
  • 91 (a)
(Rattus norvegicus)
Mammalia Rab33b 35
  • 87.48 (n)
  • 95.63 (a)
(Gallus gallus)
Aves RAB33B 35
  • 83.99 (n)
  • 95.59 (a)
RAB33B 36
  • 92 (a)
(Anolis carolinensis)
Reptilia RAB33B 36
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rab33b 35
  • 75.21 (n)
  • 83.92 (a)
Str.6559 35
(Danio rerio)
Actinopterygii Dr.11130 35
LOC572060 35
  • 71.33 (n)
  • 83.87 (a)
rab33ba 36
  • 69 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rab9D 36
  • 31 (a)
(Caenorhabditis elegans)
Secernentea rab-33 35
  • 58.24 (n)
  • 60.11 (a)
rab-33 36
  • 37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC4 36
  • 34 (a)
YPT11 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8759 36
  • 61 (a)
Species with no ortholog for RAB33B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB33B Gene

Gene Tree for RAB33B (if available)
Gene Tree for RAB33B (if available)

Paralogs for RAB33B Gene

Paralogs for RAB33B Gene

genes like me logo Genes that share paralogs with RAB33B: view

Variants for RAB33B Gene

Sequence variations from dbSNP and Humsavar for RAB33B Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs3088313 -- 139,475,777(-) ATAGC(G/T)AACTA utr-variant-3-prime
rs4074940 -- 139,474,429(+) GTATC(C/T)CATAT utr-variant-3-prime
rs4131797 -- 139,473,639(+) AGCCT(C/T)CCCAG utr-variant-3-prime
rs4131798 -- 139,473,702(+) ACATA(C/T)TTAGT utr-variant-3-prime
rs4359849 -- 139,469,527(+) aagtc(A/G)tgttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB33B Gene

Variant ID Type Subtype PubMed ID
nsv830084 CNV Loss 17160897
nsv830085 CNV Loss 17160897

Relevant External Links for RAB33B Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB33B Gene

Disorders for RAB33B Gene

(1) OMIM Diseases for RAB33B Gene (605950)


  • Smith-McCort dysplasia 2 (SMC2) [MIM:615222]: A rare autosomal recessive osteochondrodysplasia with skeletal features identical to those of Dyggve-Melchior-Clausen syndrome, but with normal intelligence and no microcephaly. It is characterized by short limbs and trunk with barrel-shaped chest. The radiographic phenotype includes platyspondyly, generalized abnormalities of the epiphyses and metaphyses, and a distinctive lacy appearance of the iliac crest. {ECO:0000269 PubMed:22652534, ECO:0000269 PubMed:23042644}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for RAB33B Gene

Relevant External Links for RAB33B

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with RAB33B: view

Publications for RAB33B Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  4. Golgi-resident small GTPase Rab33B interacts with Atg16L and modulates autophagosome formation. (PMID: 18448665) Itoh T. … Fukuda M. (Mol. Biol. Cell 2008) 3 4
  5. Rab33b and Rab6 are functionally overlapping regulators of Golgi homeostasis and trafficking. (PMID: 20163571) Starr T. … Storrie B. (Traffic 2010) 3 4

Products for RAB33B Gene

Sources for RAB33B Gene

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