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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RAB33A Gene

protein-coding   GIFtS: 55
GCID: GC0XP129305

RAB33A, member RAS oncogene family

 Explore 1 disease affiliated with
RAB33A via our new
 Human Malady Compendium 
Biological research products
for RAB33A
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
RAB33A, Member RAS Oncogene Family1 2
RabS101 2
Small GTP-Binding Protein S102 3
Ras-Related Protein Rab-33A2
RABS103

External Ids:    HGNC: 97731   Entrez Gene: 93632   Ensembl: ENSG000001345947   OMIM: 3003335   UniProtKB: Q140883   

Export aliases for RAB33A gene to outside databases

Previous GC identifers: GC0XP123951 GC0XP126151 GC0XP127250 GC0XP128011 GC0XP129031 GC0XP129133 GC0XP118701


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RAB33A:
The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. It is GTP-binding protein and may
be involved in vesicle transport. (provided by RefSeq, Jul 2008)

Gene Wiki entry for RAB33A


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_011786.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RAB33A gene promoter:
         AhR   Pax-6   ATF-2   c-Jun   Evi-1   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRAB33A promoter sequence
   Search SABiosciences Chromatin IP Primers for RAB33A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB33A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq26.1   Ensembl cytogenetic band:  Xq26.1   HGNC cytogenetic band: Xq26

RAB33A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAB33A gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP129305:  view genomic region     (about GC identifiers)

Start:
129,305,623 bp from pter      End:
129,318,844 bp from pter
Size:
13,222 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RB33A_HUMAN, Q14088 (See protein sequence)
Recommended Name: Ras-related protein Rab-33A  
Size: 237 amino acids; 26593 Da
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
Secondary accessions: Q5JUZ6 Q92465

Explore the universe of human proteins at neXtProt for RAB33A: NX_Q14088

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q14088

  • RAB33A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004785.1  
    ENSEMBL proteins: 
     ENSP00000257017  

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    Uscn Proteins for RAB33A

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--


    RAB33A for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for RAB33A


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    RAB33A for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR003579 Small_GTPase_Rab_type

    Graphical View of Domain Structure for InterPro Entry Q14088

    ProtoNet protein and cluster: Q14088

    1 Blocks protein family: IPB001806 Transforming protein P21 RAS signature

    UniProtKB/Swiss-Prot: RB33A_HUMAN, Q14088
    Similarity: Belongs to the small GTPase superfamily. Rab family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:
         Genatlas biochemistry entry for RAB33A:
    RAB33A,Ras oncogene superfamily member,expressed in brain

    miRNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB33A

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity TAS7688322
    GO:0005515protein binding IPI--
    GO:0005525GTP binding IEA--


    RAB33A for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for RAB33A:
     Decreased number of cells in m 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions0.36

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RAB33A
        Epithelial Tight Junctions


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RAB33A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/14 Interacting proteins for RAB33A (Q140881, 2, 3 ENSP000002570174) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RTN4Q9NQC32, 3, ENSP000003378384MINT-68220 I2D: score=5 STRING: ENSP00000337838
    RABAC1Q9UI141, 2, 3, ENSP000002220084EBI-744685,EBI-712367 MINT-66546 I2D: score=5 STRING: ENSP00000222008
    RTN3O951973, ENSP000003441064I2D: score=4 STRING: ENSP00000344106
    ATG16L1Q676U53I2D: score=1 
    RASA1ENSP000002743764STRING: ENSP00000274376
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process TAS7688322
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0015031protein transport IEA--


    RAB33A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RAB33A
    Search CenterWatch for drugs/clinical trials and news about RAB33A / RB33A 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RAB33A gene: 
    NM_004794.2  

    Unigene Cluster for RAB33A:

    RAB33A, member RAS oncogene family
    Hs.654356  [show with all ESTs]
    Unigene Representative Sequence: AK094927
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000257017(uc004evl.3 uc010nre.3)

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    hsa-miR-3149 hsa-miR-3934 hsa-miR-4261 hsa-miR-300 hsa-miR-3688-3p hsa-miR-381 hsa-miR-590-3p hsa-miR-1284
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    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAB33A
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    Additional cDNA sequence: 

    AF498959.1 AK094927.1 BC001157.1 BC001704.1 BC009996.2 BT007038.1 D14889.1 

    8 DOTS entries:

    DT.411309  DT.97840294  DT.100752284  DT.121278816  DT.95162596  DT.100752283  DT.121278779  DT.100022785 

    24/58 AceView cDNA sequences (see all 58):

    BQ013978 AI263411 CK300872 AK094927 AI360342 NM_004794 AF498959 AA234960 
    BQ054652 BC001157 AA809304 BQ188062 BC001704 BC009996 BG231820 AI766881 
    BQ058526 AW949801 BG218285 BQ189478 BI197877 BF529259 BI197327 BV191234 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RAB33A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGCTTGGCTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    RAB33A expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerGABAergic Amacrine CellsAmacrine, Retina
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    Mature follicles (In-vitro growth and ...)

    See RAB33A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RAB33A

    SOURCE GeneReport for Unigene cluster: Hs.654356

    UniProtKB/Swiss-Prot: RB33A_HUMAN, Q14088
    Tissue specificity: Expressed only in lymphoid cell lines

        SABiosciences Custom PCR Arrays for RAB33A
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB33A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RAB33A gene from 4/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves RAB33A1 RAB33A, member RAS oncogene family 82.69(n)
    88.46(a)
      769358  XM_001231924.2  XP_001231925.1 
    lizard
    (Anolis carolinensis)
    Reptilia RAB33A6
    --
    86(a)
    1 ↔ 1
    GL343451.1(331337-337886)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1537101 zgc:153710 73.8(n)
    82.33(a)
      751718  NM_001045428.1  NP_001038893.1 
    worm
    (Caenorhabditis elegans)
    Secernentea rab-336
    Ras-related protein Rab-33
    36(a)
    1 → many
    III(10500186-10503753)


    ENSEMBL Gene Tree for RAB33A (if available)
    TreeFam Gene Tree for RAB33A (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RAB33A gene
    RAB33B2  
    18/69 SIMAP similar genes for RAB33A using alignment to 1 protein entry:     RB33A_HUMAN(see all similar genes):
    RAB33B    DKFZp686J07132    RAB19    RAB43    RAB30    RAB1B
    RAB15    RAB10    RAB8A    RAB1C    RAB8B    RAB11A
    RAB37    RAB39B    RAB12    RAB13    RAB26    RAB2A

    RAB33A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/167 NCBI SNPs in RAB33A are shown (see all 167    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1492059131,2
    --129304064(+) GTAGTG/TTTAAT 1 -- us2k10--------
    rs2095561,2
    F--129304087(-) AACCCC/TACATT 1 -- us2k13--EA NA 52
    rs1424831831,2
    --129304238(+) CAGGTA/GTATCA 1 -- us2k10--------
    rs128488321,2
    C--129304353(+) TTGAAC/TCCCTG 1 -- us2k10--------
    rs1509290991,2
    --129304358(+) TCCCTC/GACCTT 1 -- us2k10--------
    rs128428751,2
    H--129304359(+) CCCTGA/TCCTTG 1 -- us2k14Minor allele frequency- T:0.00NS EA 414
    rs1918003381,2
    --129304444(+) GGGGAC/GAGGTA 1 -- us2k10--------
    rs2095551,2
    C,F,H,--129304461(-) TGTTTA/CTTTTA 1 -- us2k117--EA NA NS 1840
    rs1839374751,2
    --129304791(+) ATGGAA/GGGCTT 1 -- us2k10--------
    rs1882204501,2
    --129304850(+) ACCTGA/GGCCAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RAB33A (129305623 - 129318844 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for RAB33A
         2 CNVs: 83737 96961
    Locus Specific Mutation Databases (LSDB): RAB33A

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    RAB33A for disorders           About GeneDecksing

    OMIM gene information: 300333    OMIM disorders: --

    1 disease for RAB33A:    About MalaCards
    tuberculosis

    1 disease from the University of Copenhagen DISEASES database for RAB33A:
    Alport syndrome

    Export disorders for RAB33A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RAB33A gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with RAB33A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a cDNA encoding a novel small GTP-binding protein. (PubMed id 7688322)1, 2, 3 Koda T. and Kakinuma M. (1993)
    2. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. A novel Rab GTPase, Rab33B, is ubiquitously expressed and localized to the medial Golgi cisternae. (PubMed id 9512502)1, 3 Zheng J.Y....Kakinuma M. (1998)
    5. An empirical framework for binary interactome mapping . (PubMed id 19060904)1 Venkatesan K....Vidal M. (2009)
    6. Golgi-resident small GTPase Rab33B interacts with Atg16L and modulates autophagosome formation. (PubMed id 18448665)1 Itoh T....Fukuda M. (2008)
    7. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    8. Ras-associated small GTPase 33A, a novel T cell factor, is down-regulated in patients with tuberculosis. (PubMed id 16136464)1 Jacobsen M....Kaufmann S.H. (2005)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9363 HGNC: 9773 AceView: RAB33A Ensembl:ENSG00000134594 euGenes: HUgn9363
    ECgene: RAB33A H-InvDB: RAB33A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RAB33A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAB33A Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RAB33A gene:
    Search GeneIP for patents involving RAB33A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
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