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Aliases for RAB33A Gene

Aliases for RAB33A Gene

  • RAB33A, Member RAS Oncogene Family 2 3 5
  • Small GTP-Binding Protein S10 3 4
  • RabS10 3 4
  • Ras-Related Protein Rab-33A 3

External Ids for RAB33A Gene

Previous GeneCards Identifiers for RAB33A Gene

  • GC0XP123951
  • GC0XP126151
  • GC0XP127250
  • GC0XP128011
  • GC0XP129031
  • GC0XP129133
  • GC0XP129305
  • GC0XP118701

Summaries for RAB33A Gene

Entrez Gene Summary for RAB33A Gene

  • The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. It is GTP-binding protein and may be involved in vesicle transport. [provided by RefSeq, Jul 2008]

GeneCards Summary for RAB33A Gene

RAB33A (RAB33A, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB33B.

Gene Wiki entry for RAB33A Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB33A Gene

Genomics for RAB33A Gene

Regulatory Elements for RAB33A Gene

Enhancers for RAB33A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF130054 0.2 ENCODE 13.2 -116.4 -116357 1.7 CTCF RAB33A UTP14A GC0XP130039 ELF4
GH0XF130198 0.2 ENCODE 13 +27.7 27667 1.1 KDM1A RAB33A AIFM1 ZNF280C GC0XP130201
GH0XF130117 1.5 FANTOM5 Ensembl ENCODE 13 -51.8 -51782 4.6 ATF1 ZNF2 GLIS2 ZNF143 FOS ZNF263 REST MAFF SMARCA4 GLIS1 AIFM1 RAB33A ELF4 RBMX2 ZNF280C SASH3
GH0XF130124 0.9 Ensembl ENCODE 12.7 -46.3 -46303 1.9 IKZF1 CREM HES1 AIFM1 RAB33A ELF4
GH0XF130170 1 FANTOM5 ENCODE 0.8 +1.0 1049 4.4 PKNOX1 ATF1 CREB3L1 SIN3A ELK1 GATA2 ZNF263 MEF2D MAFF SMARCA4 ZNF280C ELF4 RAB33A GC0XP130201
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RAB33A on UCSC Golden Path with GeneCards custom track

Promoters for RAB33A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000261508 751 3201 PKNOX1 ATF1 CREB3L1 SIN3A ELK1 GATA2 ZNF263 MEF2D SMARCA4 PBX2

Genomic Location for RAB33A Gene

Chromosome:
X
Start:
130,171,649 bp from pter
End:
130,184,870 bp from pter
Size:
13,222 bases
Orientation:
Plus strand

Genomic View for RAB33A Gene

Genes around RAB33A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB33A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB33A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB33A Gene

Proteins for RAB33A Gene

  • Protein details for RAB33A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14088-RB33A_HUMAN
    Recommended name:
    Ras-related protein Rab-33A
    Protein Accession:
    Q14088
    Secondary Accessions:
    • Q5JUZ6
    • Q92465

    Protein attributes for RAB33A Gene

    Size:
    237 amino acids
    Molecular mass:
    26593 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RAB33A Gene

Post-translational modifications for RAB33A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB33A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for RAB33A

No data available for DME Specific Peptides for RAB33A Gene

Domains & Families for RAB33A Gene

Gene Families for RAB33A Gene

Protein Domains for RAB33A Gene

Suggested Antigen Peptide Sequences for RAB33A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14088

UniProtKB/Swiss-Prot:

RB33A_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB33A: view

Function for RAB33A Gene

Molecular function for RAB33A Gene

GENATLAS Biochemistry:
RAB33A,Ras oncogene superfamily member,expressed in brain

Gene Ontology (GO) - Molecular Function for RAB33A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity TAS 7688322
GO:0005515 protein binding IPI 16189514
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RAB33A: view
genes like me logo Genes that share phenotypes with RAB33A: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RAB33A Gene

Localization for RAB33A Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB33A Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB33A Gene COMPARTMENTS Subcellular localization image for RAB33A gene
Compartment Confidence
plasma membrane 4
cytosol 3
nucleus 2
extracellular 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for RAB33A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RAB33A: view

Pathways & Interactions for RAB33A Gene

genes like me logo Genes that share pathways with RAB33A: view

Pathways by source for RAB33A Gene

Gene Ontology (GO) - Biological Process for RAB33A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0019882 antigen processing and presentation IMP 19717423
GO:2000785 regulation of autophagosome assembly IBA --
genes like me logo Genes that share ontologies with RAB33A: view

No data available for SIGNOR curated interactions for RAB33A Gene

Transcripts for RAB33A Gene

mRNA/cDNA for RAB33A Gene

Unigene Clusters for RAB33A Gene

RAB33A, member RAS oncogene family:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB33A Gene

No ASD Table

Relevant External Links for RAB33A Gene

GeneLoc Exon Structure for
RAB33A
ECgene alternative splicing isoforms for
RAB33A

Expression for RAB33A Gene

mRNA expression in normal human tissues for RAB33A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB33A Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.9).

Protein differential expression in normal tissues from HIPED for RAB33A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (57.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RAB33A Gene



Protein tissue co-expression partners for RAB33A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RAB33A Gene:

RAB33A

SOURCE GeneReport for Unigene cluster for RAB33A Gene:

Hs.654356

mRNA Expression by UniProt/SwissProt for RAB33A Gene:

Q14088-RB33A_HUMAN
Tissue specificity: Expressed only in lymphoid cell lines.
genes like me logo Genes that share expression patterns with RAB33A: view

Primer Products

Orthologs for RAB33A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAB33A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RAB33A 35
  • 99 (a)
OneToOne
LOC784703 34
  • 95.5 (n)
chimpanzee
(Pan troglodytes)
Mammalia RAB33A 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAB33A 34 35
  • 96.48 (n)
rat
(Rattus norvegicus)
Mammalia Rab33a 34
  • 93.11 (n)
mouse
(Mus musculus)
Mammalia Rab33a 34 16 35
  • 92.26 (n)
oppossum
(Monodelphis domestica)
Mammalia RAB33A 35
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAB33A 34 35
  • 82.94 (n)
lizard
(Anolis carolinensis)
Reptilia RAB33A 35
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rab33a 34
  • 65.89 (n)
zebrafish
(Danio rerio)
Actinopterygii rab33a 34 35
  • 72.12 (n)
fruit fly
(Drosophila melanogaster)
Insecta Rab9Fb 35
  • 32 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea rab-33 35
  • 36 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC4 35
  • 36 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8759 35
  • 55 (a)
OneToMany
Species where no ortholog for RAB33A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB33A Gene

ENSEMBL:
Gene Tree for RAB33A (if available)
TreeFam:
Gene Tree for RAB33A (if available)

Paralogs for RAB33A Gene

Variants for RAB33A Gene

Sequence variations from dbSNP and Humsavar for RAB33A Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs281864468 Pathogenic 130,131,770(-) CTATG(A/T)AGCTA intron-variant, nc-transcript-variant, reference, missense, utr-variant-3-prime
rs387906500 Pathogenic 130,147,495(-) AAGAG(-/AGA)AGGTG intron-variant, nc-transcript-variant, cds-indel
rs863225431 Pathogenic 130,133,409(-) GAGGC(A/G)GGTAG intron-variant, nc-transcript-variant, reference, missense, utr-variant-3-prime
rs863225432 Pathogenic 130,140,536(-) TTGCA(A/G)CAGGT intron-variant, nc-transcript-variant, reference, missense
rs202219398 Likely pathogenic 130,133,373(+) CCAAT(A/C)TTCCA intron-variant, nc-transcript-variant, reference, missense, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RAB33A Gene

Variant ID Type Subtype PubMed ID
nsv528290 CNV gain 19592680

Variation tolerance for RAB33A Gene

Residual Variation Intolerance Score: 35.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.66; 31.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAB33A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAB33A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB33A Gene

Disorders for RAB33A Gene

Relevant External Links for RAB33A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAB33A

No disorders were found for RAB33A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB33A Gene

Publications for RAB33A Gene

  1. Molecular cloning of a cDNA encoding a novel small GTP-binding protein. (PMID: 7688322) Koda T. … Kakinuma M. (FEBS Lett. 1993) 2 3 4 64
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. A novel Rab GTPase, Rab33B, is ubiquitously expressed and localized to the medial Golgi cisternae. (PMID: 9512502) Zheng J.Y. … Kakinuma M. (J. Cell. Sci. 1998) 2 3 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for RAB33A Gene

Sources for RAB33A Gene

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