RAB33A Gene
protein-coding GIFtS : 55
GCID: GC0X P129305
RAB33A, member RAS oncogene family
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Aliasesfor RAB33A gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases RAB33A, Member RAS Oncogene Family 1 2 RabS101 2 Small GTP-Binding Protein S102 3 Ras-Related Protein Rab-33A2 RABS103
Export aliases for RAB33A gene to outside databases Previous GC identifers: GC0XP123951 GC0XP126151 GC0XP127250 GC0XP128011 GC0XP129031 GC0XP129133 GC0XP118701
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Summariesfor RAB33A gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for RAB33A : The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. It is GTP-binding protein and may be involved in vesicle transport. (provided by RefSeq, Jul 2008) Gene Wiki entry for RAB33A
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Genomic Viewsfor RAB33A gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000023.10 NC_018934.1 NT_011786.16 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the RAB33A gene promoter: AhR Pax-6 ATF-2 c-Jun Evi-1 Arnt Other transcription factors Search SABiosciences Chromatin IP Primers for RAB33A Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat RAB33A
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: Xq26.1 Ensembl cytogenetic band: Xq26.1 HGNC cytogenetic band: Xq26 RAB33A Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome X GeneLoc Exon Structure
GeneLoc location for GC0XP129305: view genomic region
(about GC identifiers )
Start:
129,305,623 bp from pter
End:
129,318,844 bp from pter
Size:
13,222 bases
Orientation:
plus strand
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Proteinsfor RAB33A gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: RB33A_HUMAN, Q14088 (See
protein sequence )Recommended Name: Ras-related protein Rab-33A Size : 237 amino acids; 26593 Da
Subcellular location : Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
Secondary accessions : Q5JUZ6 Q92465Explore the universe of human proteins at neXtProt for RAB33A: NX_Q14088 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q14088 RAB33A Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_004785.1 ENSEMBL proteins: ENSP00000257017 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005886 plasma membrane
IEA --
RAB33A for ontologies About GeneDecksing RAB33A Antibody Products: Assay Products for RAB33A:
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Protein
Domains / Familiesfor RAB33A gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
RAB33A for domains About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q14088 ProtoNet protein and cluster: Q14088
1 Blocks protein family : IPB001806 Transforming protein P21 RAS signature UniProtKB/Swiss-Prot: RB33A_HUMAN, Q14088 Similarity : Belongs to the small GTPase superfamily. Rab family
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Functionfor RAB33A gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: Genatlas biochemistry entry for RAB33A : RAB33A,Ras oncogene superfamily member,expressed in brain Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for RAB33A (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for RAB33AOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: RAB33A (NM_004794 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RAB33A Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RAB33A
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB33A
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view) : About this table
RAB33A for ontologies About GeneDecksing 1 GenomeRNAi human phenotype for RAB33A :
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Pathways & Interactionsfor RAB33A gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways   About this table See pathways by source Super-pathway contained gene-specific pathways 1 Sertoli-Sertoli Cell Junction Dynamics
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RAB33A Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RAB33A STRING Interaction
Network Preview (showing 5 interactants - click image to see 10)5/14 Interacting proteins for RAB33A (Q14088 1 , 2 , 3 ENSP00000257017 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 14 )About this table Gene Ontology (GO): 3 biological process terms (GO ID links to tree view) : About this table
RAB33A for ontologies About GeneDecksing
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Drugs & Compoundsfor RAB33A gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for RAB33A Search CenterWatch for drugs/clinical trials and news about RAB33A / RB33A
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Transcriptsfor RAB33A gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for RAB33A gene: NM_004794.2 Unigene Cluster for RAB33A:
RAB33A, member RAS oncogene family Hs.654356 [show with all ESTs ] Unigene Representative Sequence: AK094927 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000257017 (uc004evl.3 uc010nre.3 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for RAB33A (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for RAB33AOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: RAB33A (NM_004794 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RAB33A Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RAB33A
Additional cDNA sequence: AF498959.1 AK094927.1 BC001157.1 BC001704.1 BC009996.2 BT007038.1 D14889.1
8 DOTS entries : DT.411309 DT.97840294
DT.100752284 DT.121278816 DT.95162596 DT.100752283 DT.121278779 DT.100022785 24/58 AceView cDNA sequences (see all 58 ):
BQ013978 AI263411 CK300872 AK094927 AI360342 NM_004794 AF498959 AA234960 BQ054652 BC001157 AA809304 BQ188062 BC001704 BC009996 BG231820 AI766881 BQ058526 AW949801 BG218285 BQ189478 BI197877 BF529259 BI197327 BV191234 GeneLoc Exon Structure
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Expression for RAB33A gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section RAB33A expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TGCTTGGCTT
About this image RAB33A expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See RAB33A Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for RAB33A SOURCE GeneReport for Unigene cluster: Hs.654356 UniProtKB/Swiss-Prot: RB33A_HUMAN, Q14088 Tissue specificity : Expressed only in lymphoid cell lines SABiosciences Custom PCR Arrays for RAB33A Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for RAB33ABrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat RAB33A QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat RAB33A QIAGEN QuantiFast Probe-based Assays in human , mouse , rat RAB33A In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB33A
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Orthologsfor RAB33A gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for RAB33A gene from 4/15 species (see all 15 ) About this table
ENSEMBL Gene Tree for RAB33A (if available)TreeFam Gene Tree for RAB33A (if available)
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Paralogsfor RAB33A gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for RAB33A gene RAB33B 2 18/69 SIMAP similar genes for RAB33A using alignment to 1 protein entry: RB33A_HUMAN (see all similar genes ):RAB33B DKFZp686J07132 RAB19 RAB43 RAB30 RAB1B RAB15 RAB10 RAB8A RAB1C RAB8B RAB11A RAB37 RAB39B RAB12 RAB13 RAB26 RAB2A
RAB33A for paralogs About GeneDecksing
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Genomic Variantsfor RAB33A gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr X pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for RAB33A (129305623 - 129318844 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for RAB33A 2 CNVs : 83737 96961 Locus Specific Mutation Databases (LSDB): RAB33A
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing RAB33A
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Disorders
/ Diseasesfor RAB33A gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
RAB33A for disorders About GeneDecksing
OMIM gene information: 300333
OMIM disorders : --1 disease for RAB33A : About MalaCards tuberculosis 1 disease from the University of Copenhagen DISEASES database for RAB33A :Alport syndrome Export disorders for RAB33A gene to outside databases
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Publicationsfor RAB33A gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for RAB33A gene, integrated from 9 sources (see all 11 ): (articles sorted by number of sources associating them with RAB33A) Utopia : connect your pdf to the dynamic world of online information
Molecular cloning of a cDNA encoding a novel small GTP-binding protein. (PubMed id 7688322) 1 , 2 , 3 Koda T. and Kakinuma M. (1993) The DNA sequence of the human X chromosome. (PubMed id 15772651) 1 , 2 Ross M.T.... Bentley D.R. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) A novel Rab GTPase, Rab33B, is ubiquitously expressed and localized to the medial Golgi cisternae. (PubMed id 9512502) 1 , 3 Zheng J.Y....Kakinuma M. (1998) An empirical framework for binary interactome mapping . (PubMed id 19060904) 1 Venkatesan K....Vidal M. (2009) Golgi-resident small GTPase Rab33B interacts with Atg16L and modulates autophagosome formation. (PubMed id 18448665) 1 Itoh T....Fukuda M. (2008) Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514) 1 Rual J.F....Vidal M. (2005) Ras-associated small GTPase 33A, a novel T cell factor, is down-regulated in patients with tuberculosis. (PubMed id 16136464) 1 Jacobsen M....Kaufmann S.H. (2005) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 Ota T.... Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for RAB33A gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing RAB33A gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing RAB33A gene
(According to HUGE )
About This Section --
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Specialized Databases showing RAB33A gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for RAB33A gene: Search GeneIP for patents involving RAB33A GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor RAB33A gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for RAB33A OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for RAB33A OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for RAB33A OriGene Protein Over-expression Lysate for RAB33A Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for RAB33A Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for RAB33A OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for RAB33A Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for RAB33A OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for RAB33A OriGene Custom Protein Services for RAB33A OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RAB33A QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing RAB33A QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat RAB33A QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat RAB33A QIAGEN QuantiFast Probe-based Assays in human , mouse , rat RAB33A QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat RAB33A
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