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Aliases for RAB32 Gene

Aliases for RAB32 Gene

  • RAB32, Member RAS Oncogene Family 2 3

External Ids for RAB32 Gene

Summaries for RAB32 Gene

Entrez Gene Summary for RAB32 Gene

  • Small GTP-binding proteins of the RAB family, such as RAB32, play essential roles in vesicle and granule targeting (Bao et al., 2002 [PubMed 11784320]).[supplied by OMIM, Aug 2009]

GeneCards Summary for RAB32 Gene

RAB32 (RAB32, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB32 include hermansky-pudlak syndrome. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include GTP binding. An important paralog of this gene is RAB9A.

UniProtKB/Swiss-Prot for RAB32 Gene

  • Acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB32 Gene

Genomics for RAB32 Gene

Genomic Location for RAB32 Gene

Start:
146,543,692 bp from pter
End:
146,554,965 bp from pter
Size:
11,274 bases
Orientation:
Plus strand

Genomic View for RAB32 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAB32 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB32 Gene

Regulatory Elements for RAB32 Gene

Proteins for RAB32 Gene

  • Protein details for RAB32 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13637-RAB32_HUMAN
    Recommended name:
    Ras-related protein Rab-32
    Protein Accession:
    Q13637
    Secondary Accessions:

    Protein attributes for RAB32 Gene

    Size:
    225 amino acids
    Molecular mass:
    24997 Da
    Quaternary structure:
    • Interacts with ANKRD27 (PubMed:24856514).

    Three dimensional structures from OCA and Proteopedia for RAB32 Gene

neXtProt entry for RAB32 Gene

Proteomics data for RAB32 Gene at MOPED

Post-translational modifications for RAB32 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB32 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RAB32 Gene

Domains for RAB32 Gene

Gene Families for RAB32 Gene

HGNC:
  • AKAP :A-kinase anchor proteins
  • RAB :RAB, member RAS oncogene

UniProtKB/Swiss-Prot:

RAB32_HUMAN
Family:
  • Belongs to the small GTPase superfamily. Rab family.:
    • Q13637
genes like me logo Genes that share domains with RAB32: view

Function for RAB32 Gene

Molecular function for RAB32 Gene

UniProtKB/Swiss-Prot Function: Acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.

Gene Ontology (GO) - Molecular Function for RAB32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IDA 21808068
GO:0005515 protein binding IPI 21808068
GO:0005525 GTP binding NAS 22511774
GO:0030742 GTP-dependent protein binding IPI 22511774
GO:0032403 protein complex binding --
genes like me logo Genes that share ontologies with RAB32: view

miRNA for RAB32 Gene

miRTarBase miRNAs that target RAB32

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RAB32 Gene

Localization for RAB32 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB32 Gene

Mitochondrion. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB32 Gene COMPARTMENTS Subcellular localization image for RAB32 gene
Compartment Confidence
mitochondrion 5
cytosol 3
endosome 2
lysosome 2
nucleus 2
vacuole 2
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RAB32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005737 cytoplasm --
GO:0005739 mitochondrion IBA --
GO:0005769 early endosome IDA 22511774
genes like me logo Genes that share ontologies with RAB32: view

Pathways for RAB32 Gene

genes like me logo Genes that share pathways with RAB32: view

Pathways by source for RAB32 Gene

1 Qiagen pathway for RAB32 Gene

Gene Ontology (GO) - Biological Process for RAB32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport IBA --
GO:0006913 nucleocytoplasmic transport --
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction --
genes like me logo Genes that share ontologies with RAB32: view

Transcripts for RAB32 Gene

mRNA/cDNA for RAB32 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(149) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RAB32 Gene

RAB32, member RAS oncogene family:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAB32 Gene

No ASD Table

Relevant External Links for RAB32 Gene

GeneLoc Exon Structure for
RAB32
ECgene alternative splicing isoforms for
RAB32

Expression for RAB32 Gene

mRNA expression in normal human tissues for RAB32 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB32 Gene

This gene is overexpressed in Whole Blood (11.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB32 Gene

SOURCE GeneReport for Unigene cluster for RAB32 Gene Hs.287714

mRNA Expression by UniProt/SwissProt for RAB32 Gene

Q13637-RAB32_HUMAN
Tissue specificity: Widely expressed with high levels in heart, liver, kidney, bone marrow, testis, colon and fetal lung.
genes like me logo Genes that share expressions with RAB32: view

Orthologs for RAB32 Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB32 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB32 36
  • 99.41 (n)
  • 99.56 (a)
RAB32 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RAB32 36
  • 89.76 (n)
  • 89.27 (a)
RAB32 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAB32 36
  • 89.63 (n)
  • 88.15 (a)
RAB32 37
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rab32 36
  • 86.57 (n)
  • 86.89 (a)
Rab32 16
Rab32 37
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAB32 37
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAB32 37
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rab32 36
  • 86.08 (n)
  • 87.38 (a)
chicken
(Gallus gallus)
Aves RAB32 36
  • 82.2 (n)
  • 84.95 (a)
RAB32 37
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAB32 37
  • 78 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25385 36
tropical clawed frog
(Silurana tropicalis)
Amphibia rab32 36
  • 76.38 (n)
  • 80.58 (a)
Str.20254 36
zebrafish
(Danio rerio)
Actinopterygii rab32 36
rab32a 36
  • 73.46 (n)
  • 79.61 (a)
rab32a 37
  • 60 (a)
OneToMany
rab32b 37
  • 47 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007654 36
  • 70.97 (n)
  • 75.28 (a)
fruit fly
(Drosophila melanogaster)
Insecta ltd 36
  • 65.37 (n)
  • 69.27 (a)
ltd 37
  • 21 (a)
OneToMany
Rab-RP1 38
  • 67 (a)
worm
(Caenorhabditis elegans)
Secernentea glo-1 36
  • 55.56 (n)
  • 52.82 (a)
glo-1 37
  • 47 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 65 (a)
OneToOne
Species with no ortholog for RAB32:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB32 Gene

ENSEMBL:
Gene Tree for RAB32 (if available)
TreeFam:
Gene Tree for RAB32 (if available)

Paralogs for RAB32 Gene

Paralogs for RAB32 Gene

genes like me logo Genes that share paralogs with RAB32: view

Variants for RAB32 Gene

Sequence variations from dbSNP and Humsavar for RAB32 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs13574 -- 146,554,569(+) CAAGA(G/T)ACCTT reference, missense
rs1804729 -- 146,549,645(+) AACAA(A/T)TGTGA reference, missense
rs1853320 -- 146,555,263(+) CAAAC(A/G)AACCT downstream-variant-500B
rs2146033 -- 146,546,836(+) GTGAA(A/G)AAATT intron-variant
rs3804282 -- 146,554,186(-) CTCGA(C/T)GGTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB32 Gene

Variant ID Type Subtype PubMed ID
nsv886749 CNV Gain 21882294
esv2675425 CNV Deletion 23128226

Relevant External Links for RAB32 Gene

HapMap Linkage Disequilibrium report
RAB32

Disorders for RAB32 Gene

(1) University of Copenhagen DISEASES for RAB32 Gene

Relevant External Links for RAB32

Genetic Association Database (GAD)
RAB32
Human Genome Epidemiology (HuGE) Navigator
RAB32
genes like me logo Genes that share disorders with RAB32: view

No data available for UniProtKB/Swiss-Prot for RAB32 Gene

Publications for RAB32 Gene

  1. Molecular cloning, bacterial expression and properties of Rab31 and Rab32. (PMID: 11784320) Bao X. … Haslam R.J. (Eur. J. Biochem. 2002) 3 4
  2. Rab32 is an A-kinase anchoring protein and participates in mitochondrial dynamics. (PMID: 12186851) Alto N.M. … Scott J.D. (J. Cell Biol. 2002) 3 4
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes. (PMID: 21255211) Seto S. … Koide Y. (Traffic 2011) 3 4

Products for RAB32 Gene

Sources for RAB32 Gene

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