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Aliases for RAB32 Gene

Aliases for RAB32 Gene

  • RAB32, Member RAS Oncogene Family 2 3

External Ids for RAB32 Gene

Previous GeneCards Identifiers for RAB32 Gene

  • GC06P146711
  • GC06P146845
  • GC06P146906
  • GC06P144428

Summaries for RAB32 Gene

Entrez Gene Summary for RAB32 Gene

  • Small GTP-binding proteins of the RAB family, such as RAB32, play essential roles in vesicle and granule targeting (Bao et al., 2002 [PubMed 11784320]).[supplied by OMIM, Aug 2009]

GeneCards Summary for RAB32 Gene

RAB32 (RAB32, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB32 include hermansky-pudlak syndrome. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include GTP binding and protein complex binding. An important paralog of this gene is RAB9A.

UniProtKB/Swiss-Prot for RAB32 Gene

  • Acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB32 Gene

Genomics for RAB32 Gene

Regulatory Elements for RAB32 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RAB32 Gene

Chromosome:
6
Start:
146,543,692 bp from pter
End:
146,554,965 bp from pter
Size:
11,274 bases
Orientation:
Plus strand

Genomic View for RAB32 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAB32 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB32 Gene

Proteins for RAB32 Gene

  • Protein details for RAB32 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13637-RAB32_HUMAN
    Recommended name:
    Ras-related protein Rab-32
    Protein Accession:
    Q13637

    Protein attributes for RAB32 Gene

    Size:
    225 amino acids
    Molecular mass:
    24997 Da
    Quaternary structure:
    • Interacts with ANKRD27 (PubMed:24856514).

    Three dimensional structures from OCA and Proteopedia for RAB32 Gene

neXtProt entry for RAB32 Gene

Proteomics data for RAB32 Gene at MOPED

Post-translational modifications for RAB32 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB32 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RAB32 Gene

Domains & Families for RAB32 Gene

Suggested Antigen Peptide Sequences for RAB32 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13637

UniProtKB/Swiss-Prot:

RAB32_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB32: view

Function for RAB32 Gene

Molecular function for RAB32 Gene

UniProtKB/Swiss-Prot Function:
Acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.

Gene Ontology (GO) - Molecular Function for RAB32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IDA 21808068
GO:0005515 protein binding IPI 21808068
GO:0005525 GTP binding NAS 22511774
GO:0030742 GTP-dependent protein binding IPI 22511774
GO:0035612 NOT AP-2 adaptor complex binding IDA 22511774
genes like me logo Genes that share ontologies with RAB32: view

Phenotypes for RAB32 Gene

genes like me logo Genes that share phenotypes with RAB32: view

Animal Model Products

miRNA for RAB32 Gene

miRTarBase miRNAs that target RAB32

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB32 Gene

Localization for RAB32 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB32 Gene

Mitochondrion. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB32 Gene COMPARTMENTS Subcellular localization image for RAB32 gene
Compartment Confidence
endosome 4
golgi apparatus 3
mitochondrion 3
cytosol 2
lysosome 2
vacuole 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for RAB32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005739 mitochondrion IBA --
GO:0005769 early endosome IDA 22511774
GO:0005802 trans-Golgi network IBA --
GO:0016020 membrane IDA 22511774
genes like me logo Genes that share ontologies with RAB32: view

Pathways & Interactions for RAB32 Gene

genes like me logo Genes that share pathways with RAB32: view

Pathways by source for RAB32 Gene

1 Qiagen pathway for RAB32 Gene

Gene Ontology (GO) - Biological Process for RAB32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA --
GO:0006913 nucleocytoplasmic transport --
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction --
GO:0015031 protein transport --
genes like me logo Genes that share ontologies with RAB32: view

No data available for SIGNOR curated interactions for RAB32 Gene

Drugs & Compounds for RAB32 Gene

No Compound Related Data Available

Transcripts for RAB32 Gene

mRNA/cDNA for RAB32 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(149) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RAB32 Gene

RAB32, member RAS oncogene family:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAB32

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB32 Gene

No ASD Table

Relevant External Links for RAB32 Gene

GeneLoc Exon Structure for
RAB32
ECgene alternative splicing isoforms for
RAB32

Expression for RAB32 Gene

mRNA expression in normal human tissues for RAB32 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB32 Gene

This gene is overexpressed in Whole Blood (x11.7).

Protein differential expression in normal tissues from HIPED for RAB32 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.4) and Platelet (15.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB32 Gene



SOURCE GeneReport for Unigene cluster for RAB32 Gene Hs.287714

mRNA Expression by UniProt/SwissProt for RAB32 Gene

Q13637-RAB32_HUMAN
Tissue specificity: Widely expressed with high levels in heart, liver, kidney, bone marrow, testis, colon and fetal lung.
genes like me logo Genes that share expression patterns with RAB32: view

Protein tissue co-expression partners for RAB32 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for RAB32 Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB32 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RAB32 35
  • 89.76 (n)
  • 89.27 (a)
RAB32 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAB32 35
  • 89.63 (n)
  • 88.15 (a)
RAB32 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rab32 35
  • 86.57 (n)
  • 86.89 (a)
Rab32 16
Rab32 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RAB32 35
  • 99.41 (n)
  • 99.56 (a)
RAB32 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rab32 35
  • 86.08 (n)
  • 87.38 (a)
oppossum
(Monodelphis domestica)
Mammalia RAB32 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAB32 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAB32 35
  • 82.2 (n)
  • 84.95 (a)
RAB32 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAB32 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rab32 35
  • 76.38 (n)
  • 80.58 (a)
Str.20254 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.25385 35
zebrafish
(Danio rerio)
Actinopterygii rab32 35
rab32a 35
  • 73.46 (n)
  • 79.61 (a)
rab32a 36
  • 60 (a)
OneToMany
rab32b 36
  • 47 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Rab-RP1 37
  • 67 (a)
ltd 35
  • 65.37 (n)
  • 69.27 (a)
ltd 36
  • 21 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007654 35
  • 70.97 (n)
  • 75.28 (a)
worm
(Caenorhabditis elegans)
Secernentea glo-1 35
  • 55.56 (n)
  • 52.82 (a)
glo-1 36
  • 47 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 65 (a)
OneToOne
Species with no ortholog for RAB32:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB32 Gene

ENSEMBL:
Gene Tree for RAB32 (if available)
TreeFam:
Gene Tree for RAB32 (if available)

Paralogs for RAB32 Gene

Paralogs for RAB32 Gene

genes like me logo Genes that share paralogs with RAB32: view

Variants for RAB32 Gene

Sequence variations from dbSNP and Humsavar for RAB32 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs13574 -- 146,554,569(+) CAAGA(A/G/T)ACCTT synonymous-codon, reference
rs1804729 -- 146,549,645(+) AACAA(A/C/T)TGTGA reference, missense
rs1853320 -- 146,555,263(+) CAAAC(A/G)AACCT downstream-variant-500B
rs2146033 -- 146,546,836(+) GTGAA(A/G)AAATT intron-variant
rs3804282 -- 146,554,186(-) CTCGA(C/T)GGTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB32 Gene

Variant ID Type Subtype PubMed ID
nsv886749 CNV Gain 21882294
esv2675425 CNV Deletion 23128226

Variation tolerance for RAB32 Gene

Residual Variation Intolerance Score: 31.11% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.65; 13.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAB32 Gene

HapMap Linkage Disequilibrium report
RAB32

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB32 Gene

Disorders for RAB32 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RAB32 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hermansky-pudlak syndrome
  • platelet storage pool deficiency
- elite association
Search RAB32 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RAB32

Genetic Association Database (GAD)
RAB32
Human Genome Epidemiology (HuGE) Navigator
RAB32
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAB32
genes like me logo Genes that share disorders with RAB32: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RAB32 Gene

Publications for RAB32 Gene

  1. Molecular phenotype of inflammatory bowel disease-associated neoplasms with microsatellite instability. (PMID: 16012936) Schulmann K. … Meltzer S.J. (Gastroenterology 2005) 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 67
  4. Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy. (PMID: 25642632) Liu H. … Zhang F. (Nat. Genet. 2015) 67
  5. LRRK2 transport is regulated by its novel interacting partner Rab32. (PMID: 25360523) WaschbA1sch D. … Barnekow A. (PLoS ONE 2014) 67

Products for RAB32 Gene

Sources for RAB32 Gene

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