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Aliases for RAB32 Gene

Aliases for RAB32 Gene

  • RAB32, Member RAS Oncogene Family 2 3

External Ids for RAB32 Gene

Previous GeneCards Identifiers for RAB32 Gene

  • GC06P146711
  • GC06P146845
  • GC06P146906
  • GC06P144428

Summaries for RAB32 Gene

Entrez Gene Summary for RAB32 Gene

  • Small GTP-binding proteins of the RAB family, such as RAB32, play essential roles in vesicle and granule targeting (Bao et al., 2002 [PubMed 11784320]).[supplied by OMIM, Aug 2009]

GeneCards Summary for RAB32 Gene

RAB32 (RAB32, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB32 include hermansky-pudlak syndrome. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include GTP binding. An important paralog of this gene is RAB9A.

UniProtKB/Swiss-Prot for RAB32 Gene

  • Acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB32 Gene

Genomics for RAB32 Gene

Regulatory Elements for RAB32 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RAB32 Gene

146,543,692 bp from pter
146,554,965 bp from pter
11,274 bases
Plus strand

Genomic View for RAB32 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAB32 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB32 Gene

Proteins for RAB32 Gene

  • Protein details for RAB32 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras-related protein Rab-32
    Protein Accession:
    Secondary Accessions:

    Protein attributes for RAB32 Gene

    225 amino acids
    Molecular mass:
    24997 Da
    Quaternary structure:
    • Interacts with ANKRD27 (PubMed:24856514).

    Three dimensional structures from OCA and Proteopedia for RAB32 Gene

neXtProt entry for RAB32 Gene

Proteomics data for RAB32 Gene at MOPED

Post-translational modifications for RAB32 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB32 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RAB32 Gene

Domains for RAB32 Gene

Gene Families for RAB32 Gene

  • AKAP :A-kinase anchor proteins
  • RAB :RAB, member RAS oncogene

Suggested Antigen Peptide Sequences for RAB32 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q13637
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB32: view

Function for RAB32 Gene

Molecular function for RAB32 Gene

UniProtKB/Swiss-Prot Function: Acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.

Gene Ontology (GO) - Molecular Function for RAB32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IDA 21808068
GO:0005515 protein binding IPI 21808068
GO:0005525 GTP binding NAS 22511774
GO:0030742 GTP-dependent protein binding IPI 22511774
GO:0032403 protein complex binding --
genes like me logo Genes that share ontologies with RAB32: view

Animal Model Products

CRISPR Products

miRNA for RAB32 Gene

miRTarBase miRNAs that target RAB32

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RAB32 Gene

Localization for RAB32 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB32 Gene

Mitochondrion. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis.

Subcellular locations from

Jensen Localization Image for RAB32 Gene COMPARTMENTS Subcellular localization image for RAB32 gene
Compartment Confidence
mitochondrion 5
cytosol 3
endosome 2
lysosome 2
nucleus 2
vacuole 2
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RAB32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005737 cytoplasm --
GO:0005739 mitochondrion IBA --
GO:0005769 early endosome IDA 22511774
genes like me logo Genes that share ontologies with RAB32: view

Pathways for RAB32 Gene

genes like me logo Genes that share pathways with RAB32: view

Pathways by source for RAB32 Gene

1 Qiagen pathway for RAB32 Gene

Gene Ontology (GO) - Biological Process for RAB32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport IBA --
GO:0006913 nucleocytoplasmic transport --
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction --
genes like me logo Genes that share ontologies with RAB32: view

Transcripts for RAB32 Gene

mRNA/cDNA for RAB32 Gene

(149) Selected AceView cDNA sequences:
(6) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RAB32 Gene

RAB32, member RAS oncogene family:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAB32

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB32 Gene

No ASD Table

Relevant External Links for RAB32 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RAB32 Gene

mRNA expression in normal human tissues for RAB32 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB32 Gene

This gene is overexpressed in Whole Blood (11.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB32 Gene

SOURCE GeneReport for Unigene cluster for RAB32 Gene Hs.287714

mRNA Expression by UniProt/SwissProt for RAB32 Gene

Tissue specificity: Widely expressed with high levels in heart, liver, kidney, bone marrow, testis, colon and fetal lung.
genes like me logo Genes that share expressions with RAB32: view

In Situ Assay Products

Orthologs for RAB32 Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB32 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RAB32 35
  • 99.41 (n)
  • 99.56 (a)
RAB32 36
  • 100 (a)
(Bos Taurus)
Mammalia RAB32 35
  • 89.76 (n)
  • 89.27 (a)
RAB32 36
  • 88 (a)
(Canis familiaris)
Mammalia RAB32 35
  • 89.63 (n)
  • 88.15 (a)
RAB32 36
  • 80 (a)
(Mus musculus)
Mammalia Rab32 35
  • 86.57 (n)
  • 86.89 (a)
Rab32 16
Rab32 36
  • 84 (a)
(Monodelphis domestica)
Mammalia RAB32 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia RAB32 36
  • 80 (a)
(Rattus norvegicus)
Mammalia Rab32 35
  • 86.08 (n)
  • 87.38 (a)
(Gallus gallus)
Aves RAB32 35
  • 82.2 (n)
  • 84.95 (a)
RAB32 36
  • 79 (a)
(Anolis carolinensis)
Reptilia RAB32 36
  • 78 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.25385 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rab32 35
  • 76.38 (n)
  • 80.58 (a)
Str.20254 35
(Danio rerio)
Actinopterygii rab32 35
rab32a 35
  • 73.46 (n)
  • 79.61 (a)
rab32a 36
  • 60 (a)
rab32b 36
  • 47 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007654 35
  • 70.97 (n)
  • 75.28 (a)
fruit fly
(Drosophila melanogaster)
Insecta ltd 35
  • 65.37 (n)
  • 69.27 (a)
ltd 36
  • 21 (a)
Rab-RP1 37
  • 67 (a)
(Caenorhabditis elegans)
Secernentea glo-1 35
  • 55.56 (n)
  • 52.82 (a)
glo-1 36
  • 47 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 65 (a)
Species with no ortholog for RAB32:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB32 Gene

Gene Tree for RAB32 (if available)
Gene Tree for RAB32 (if available)

Paralogs for RAB32 Gene

Paralogs for RAB32 Gene

genes like me logo Genes that share paralogs with RAB32: view

Variants for RAB32 Gene

Sequence variations from dbSNP and Humsavar for RAB32 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs13574 -- 146,554,569(+) CAAGA(G/T)ACCTT reference, missense
rs1804729 -- 146,549,645(+) AACAA(A/T)TGTGA reference, missense
rs1853320 -- 146,555,263(+) CAAAC(A/G)AACCT downstream-variant-500B
rs2146033 -- 146,546,836(+) GTGAA(A/G)AAATT intron-variant
rs3804282 -- 146,554,186(-) CTCGA(C/T)GGTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB32 Gene

Variant ID Type Subtype PubMed ID
nsv886749 CNV Gain 21882294
esv2675425 CNV Deletion 23128226

Relevant External Links for RAB32 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB32 Gene

Disorders for RAB32 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for RAB32 Gene including...

Search for RAB32 Gene in MalaCards »

(1) University of Copenhagen DISEASES for RAB32 Gene

Relevant External Links for RAB32

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with RAB32: view

No data available for UniProtKB/Swiss-Prot for RAB32 Gene

Publications for RAB32 Gene

  1. Molecular cloning, bacterial expression and properties of Rab31 and Rab32. (PMID: 11784320) Bao X. … Haslam R.J. (Eur. J. Biochem. 2002) 3 4
  2. Rab32 is an A-kinase anchoring protein and participates in mitochondrial dynamics. (PMID: 12186851) Alto N.M. … Scott J.D. (J. Cell Biol. 2002) 3 4
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes. (PMID: 21255211) Seto S. … Koide Y. (Traffic 2011) 3 4

Products for RAB32 Gene

Sources for RAB32 Gene

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