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Aliases for RAB32 Gene

Aliases for RAB32 Gene

  • RAB32, Member RAS Oncogene Family 2 3 5

External Ids for RAB32 Gene

Previous GeneCards Identifiers for RAB32 Gene

  • GC06P146711
  • GC06P146845
  • GC06P146906
  • GC06P144428

Summaries for RAB32 Gene

Entrez Gene Summary for RAB32 Gene

  • The protein encoded by this gene anchors the type II regulatory subunit of protein kinase A to the mitochondrion and aids in mitochondrial fission. The encoded protein also appears to be involved in autophagy and melanosome secretion. Variations in this gene may be linked to leprosy. [provided by RefSeq, Dec 2015]

GeneCards Summary for RAB32 Gene

RAB32 (RAB32, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB32 include Leprosy. Among its related pathways are Vesicle-mediated transport and RAB geranylgeranylation. GO annotations related to this gene include GTP binding and protein complex binding. An important paralog of this gene is RAB38.

UniProtKB/Swiss-Prot for RAB32 Gene

  • Acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission (PubMed:12186851). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed:21255211). Plays an important role in the control of melanin production and melanosome biogenesis (PubMed:23084991). In concert with RAB38, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB32 Gene

Genomics for RAB32 Gene

Regulatory Elements for RAB32 Gene

Enhancers for RAB32 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G146595 1 Ensembl ENCODE 11.2 +52.5 52471 0.5 SMARCE1 SMARCA5 CEBPB DPF2 CHAMP1 FOSL1 ARID1B JUND SMARCA4 ATF3 RAB32 LOC101928661 GC06M146554
GH06G146700 0.7 ENCODE 11.2 +156.6 156568 0.2 ELF3 CTCF NFIB ZNF133 ZNF2 RAD21 RELA NCOR1 ZNF143 SMC3 RAB32 ADGB LOC101928661 LOC105378041 RNU6-906P
GH06G146339 0.7 Ensembl 10.2 -203.8 -203764 0.5 MAFG BACH1 RFX5 ZNF316 ATF3 NFE2L1 NFE2 MAFK EMSY NFE2L2 RAB32 RNA5SP222 GC06P146172
GH06G146542 1.5 FANTOM5 ENCODE 3.8 +1.7 1654 4.8 HNRNPUL1 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143 KATNBL1P6 LOC101928661 ADGB RAB32 GC06M146554
GH06G146336 0.5 ENCODE 10.2 -207.2 -207183 0.1 GATA2 PBX2 FOS RAB32 RNA5SP222 GC06P146172
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RAB32 on UCSC Golden Path with GeneCards custom track

Promoters for RAB32 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000204630 408 2201 HNRNPUL1 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 BRCA1 ZNF48 YY1

Genomic Location for RAB32 Gene

Chromosome:
6
Start:
146,543,692 bp from pter
End:
146,554,965 bp from pter
Size:
11,274 bases
Orientation:
Plus strand

Genomic View for RAB32 Gene

Genes around RAB32 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB32 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB32 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB32 Gene

Proteins for RAB32 Gene

  • Protein details for RAB32 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13637-RAB32_HUMAN
    Recommended name:
    Ras-related protein Rab-32
    Protein Accession:
    Q13637

    Protein attributes for RAB32 Gene

    Size:
    225 amino acids
    Molecular mass:
    24997 Da
    Quaternary structure:
    • Interacts with ANKRD27 (PubMed:24856514, PubMed:21269460). A decreased interaction with ANKRD27 seen in the presence of SGSM2 (PubMed:21269460).

    Three dimensional structures from OCA and Proteopedia for RAB32 Gene

neXtProt entry for RAB32 Gene

Post-translational modifications for RAB32 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB32 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RAB32 Gene

Domains & Families for RAB32 Gene

Suggested Antigen Peptide Sequences for RAB32 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13637

UniProtKB/Swiss-Prot:

RAB32_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB32: view

Function for RAB32 Gene

Molecular function for RAB32 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Regulated by a guanine nucleotide-exchange factor (GEF) and a GTPase-activating protein (GAP) and alternates between an inactive GDP-bound and an active GTP-bound form. The BLOC-3 complex composed of HPS1 and HPS4 acts as its GEF, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form (By similarity). SGSM2 acts as its GAP and inactivates it by stimulating its GTPase activity (PubMed:21269460).
UniProtKB/Swiss-Prot Function:
Acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission (PubMed:12186851). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed:21255211). Plays an important role in the control of melanin production and melanosome biogenesis (PubMed:23084991). In concert with RAB38, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity).

Gene Ontology (GO) - Molecular Function for RAB32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IDA 21808068
GO:0005515 protein binding IPI 21808068
GO:0005525 GTP binding NAS 22511774
GO:0030742 GTP-dependent protein binding IPI 22511774
GO:0035612 NOT AP-2 adaptor complex binding IDA 22511774
genes like me logo Genes that share ontologies with RAB32: view
genes like me logo Genes that share phenotypes with RAB32: view

Animal Models for RAB32 Gene

MGI Knock Outs for RAB32:

Animal Model Products

CRISPR Products

miRNA for RAB32 Gene

miRTarBase miRNAs that target RAB32

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RAB32 Gene

Localization for RAB32 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB32 Gene

Mitochondrion. Mitochondrion outer membrane; Lipid-anchor. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Melanosome. Melanosome membrane. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211). The BLOC-3 complex, a heterodimer of HPS1 and HPS4 promotes its membrane localization (PubMed:23084991). {ECO:0000269 PubMed:21255211, ECO:0000269 PubMed:23084991}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB32 gene
Compartment Confidence
mitochondrion 5
endoplasmic reticulum 5
cytosol 5
endosome 5
golgi apparatus 4
nucleus 2
lysosome 2
plasma membrane 1
extracellular 1

Gene Ontology (GO) - Cellular Components for RAB32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 25767741
GO:0005741 mitochondrial outer membrane IEA,IDA 23084991
GO:0005769 early endosome IDA 22511774
GO:0005783 endoplasmic reticulum IDA 25767741
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with RAB32: view

Pathways & Interactions for RAB32 Gene

genes like me logo Genes that share pathways with RAB32: view

Gene Ontology (GO) - Biological Process for RAB32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007005 mitochondrion organization IMP 25767741
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0016192 vesicle-mediated transport IEA --
GO:0019882 antigen processing and presentation IMP 19717423
GO:0035646 endosome to melanosome transport IMP 22511774
genes like me logo Genes that share ontologies with RAB32: view

No data available for SIGNOR curated interactions for RAB32 Gene

Transcripts for RAB32 Gene

mRNA/cDNA for RAB32 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(149) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RAB32 Gene

RAB32, member RAS oncogene family:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB32 Gene

No ASD Table

Relevant External Links for RAB32 Gene

GeneLoc Exon Structure for
RAB32
ECgene alternative splicing isoforms for
RAB32

Expression for RAB32 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAB32 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB32 Gene

This gene is overexpressed in Whole Blood (x11.7).

Protein differential expression in normal tissues from HIPED for RAB32 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.4) and Platelet (15.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RAB32 Gene



Protein tissue co-expression partners for RAB32 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RAB32 Gene:

RAB32

SOURCE GeneReport for Unigene cluster for RAB32 Gene:

Hs.287714

mRNA Expression by UniProt/SwissProt for RAB32 Gene:

Q13637-RAB32_HUMAN
Tissue specificity: Widely expressed with high levels in heart, liver, kidney, bone marrow, testis, colon and fetal lung.

Evidence on tissue expression from TISSUES for RAB32 Gene

  • Blood(4.2)
  • Nervous system(4.2)
  • Skin(2.3)
genes like me logo Genes that share expression patterns with RAB32: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RAB32 Gene

Orthologs for RAB32 Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB32 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB32 34 35
  • 99.41 (n)
cow
(Bos Taurus)
Mammalia RAB32 34 35
  • 89.76 (n)
dog
(Canis familiaris)
Mammalia RAB32 34 35
  • 89.63 (n)
mouse
(Mus musculus)
Mammalia Rab32 34 16 35
  • 86.57 (n)
rat
(Rattus norvegicus)
Mammalia Rab32 34
  • 86.08 (n)
oppossum
(Monodelphis domestica)
Mammalia RAB32 35
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAB32 35
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAB32 34 35
  • 82.2 (n)
lizard
(Anolis carolinensis)
Reptilia RAB32 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rab32 34
  • 76.38 (n)
Str.20254 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.25385 34
zebrafish
(Danio rerio)
Actinopterygii rab32a 34 35
  • 73.46 (n)
rab32b 35
  • 47 (a)
OneToMany
rab32 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007654 34
  • 70.97 (n)
fruit fly
(Drosophila melanogaster)
Insecta Rab-RP1 36
  • 67 (a)
ltd 34 35
  • 65.37 (n)
worm
(Caenorhabditis elegans)
Secernentea glo-1 34 35
  • 55.56 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 65 (a)
OneToOne
Species where no ortholog for RAB32 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB32 Gene

ENSEMBL:
Gene Tree for RAB32 (if available)
TreeFam:
Gene Tree for RAB32 (if available)

Paralogs for RAB32 Gene

Variants for RAB32 Gene

Sequence variations from dbSNP and Humsavar for RAB32 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000070338 -- 146,542,856(+) AGAAC(G/T)CAGCC upstream-variant-2KB
rs1000525078 -- 146,543,136(+) GGAAA(A/C)CCCTA upstream-variant-2KB
rs1000864870 -- 146,548,064(+) CAGTT(A/G)GCATA intron-variant
rs1000918642 -- 146,548,304(+) CTTCT(C/T)CCATT intron-variant
rs1001212341 -- 146,555,104(+) GGCTC(A/T)TGCCT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for RAB32 Gene

Variant ID Type Subtype PubMed ID
esv2675425 CNV deletion 23128226
esv3540596 CNV deletion 23714750
esv3611155 CNV loss 21293372

Variation tolerance for RAB32 Gene

Residual Variation Intolerance Score: 31.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.65; 13.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAB32 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAB32

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB32 Gene

Disorders for RAB32 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RAB32 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
leprosy
  • leprosy 2
- elite association - COSMIC cancer census association via MalaCards
Search RAB32 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RAB32

Genetic Association Database (GAD)
RAB32
Human Genome Epidemiology (HuGE) Navigator
RAB32
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAB32
genes like me logo Genes that share disorders with RAB32: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RAB32 Gene

Publications for RAB32 Gene

  1. BLOC-3 mutated in Hermansky-Pudlak syndrome is a Rab32/38 guanine nucleotide exchange factor. (PMID: 23084991) Gerondopoulos A. … Barr F.A. (Curr. Biol. 2012) 3 4 64
  2. Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes. (PMID: 21255211) Seto S. … Koide Y. (Traffic 2011) 3 4 64
  3. RUTBC1 protein, a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins. (PMID: 21808068) Nottingham R.M. … Pfeffer S.R. (J. Biol. Chem. 2011) 3 4 64
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for RAB32 Gene

Sources for RAB32 Gene

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