V3 here soon-try beta now
Gene Search (GeneCards Home) | GeneCards Guide | User Feedback | Terms of Use | Notice about third-party sites
 

RAB31 Gene

protein-coding   GIFtS: 63

GC18P009701
RAB31, member RAS oncogene family
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
RAB22B 3
Rab-22B 3
Rab22B 1, 2
Descriptions
RAB31, member RAS oncogene family 2
External Ids
HGNC: 97711
Entrez Gene: 110312
UniProtKB: Q136363
Ensembl: ENSG000001684617
Search outside databases for aliases for RAB31 gene

Previous GC identifers: GC18P009925 GC18P009764 GC18P009699 GC18P009700

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Gene Wiki entry for RAB31
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the RAB31 gene  

Entrez Gene cytogenetic band: 18p11.3   Ensembl cytogenetic band:  18p11.22   HGNC cytogenetic band: 18p11.3

RAB31 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P009701:     (about GC identifiers)

Start:
9,764,874 bp from pter
End:
9,852,548 bp from pter
Size:
87,675 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000018.8  NT_010859.14  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: RAB31_HUMAN, Q13636 (See protein sequence)
Recommended Name: Ras-related protein Rab-31  
Size: 194 amino acids; 21569 Da
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
PDB structures from and Proteopedia :
2FG5 (3D)    
Secondary accessions: B2RBT7 Q15770 Q9HC00

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_006859.2  

    ENSEMBL proteins: 
    ENSP00000304565 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (RAB31)
    Human Recombinant Proteins from Abnova (RAB31)
                  OriGene Purified Recombinant Human Protein: RAB31 

    1 Gene Ontology (GO) cellular component term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886 plasma membrane IEA--
    About this table

    Antibodies for RAB31: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for RAB31
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (RAB31), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (RAB31)
    Novus Biologicals Antibodies for RAB31

    Assays for RAB31: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5 InterPro domains/families:
     IPR015594 Rab22-like
     IPR001806 Ras_GTPase
     IPR005225 Small_GTP_bd
     IPR003579 GTPase_Rab
     IPR013753 Ras


       GeneDecks  RAB31 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q13636

    ProtoNet protein and cluster: Q13636

    1 Blocks protein family: IPB001806 Transforming protein P21 RAS signature

    UniProtKB/Swiss-Prot: RAB31_HUMAN, Q13636
    Similarity: Belongs to the small GTPase superfamily. Rab family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (RAB31)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (RAB31)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006868

                  Applied Biosystems Silencer® siRNAs for RAB31

                  Sigma-Aldrich siRNA for RAB31  
                         Sigma-Aldrich shRNA for RAB31  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_006868
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_006868
                                     untagged cDNA clone in CMV expression vector: NM_006868 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_006868

    Genatlas biochemistry entry for RAB31:
    RAB31,RAS oncogene superfamily member,predominantly expressed in melanocytes

    3 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0003924 GTPase activity TAS8863739
    GO:0005525 GTP binding IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    2 Interacting proteins for RAB31 (ENSP000003045653 Q136362) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MPP3Q133682MINT-64788
    ANKRD27ENSP000003042923STRING (score=.71)
    About this table

    2 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007264 small GTPase mediated signal transduction IEA--
    GO:0015031 protein transport IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Enzo Life Sciences drugs & compounds for RAB31
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for RAB31
    2 PharmGKB drug compound relationships for RAB31 gene
    Drug compound PharmGKB Relations PubMed IDs for articles supporting these relationships
    mercaptopurinePD  FA  GN  12704389
    methotrexatePD  FA  GN  12704389
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (RAB31)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (RAB31)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006868

                  Sigma-Aldrich siRNA for RAB31  
                         Sigma-Aldrich shRNA for RAB31  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_006868  

    REFSEQ mRNAs for RAB31 gene: 

    NM_006868.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_006868  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_006868
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_006868
                                     untagged cDNA clone in CMV expression vector: NM_006868 

    Additional cDNA sequence: 

    AF183421.1 AF234995.1 AF498957.1 AK223505.1 AK314809.1 BC001148.1 BT020027.1 BT020028.1 
    CR407659.1 CR609335.1 CR623736.1 U57091.1 U59877.1 

    18 DOTS entries:

    DT.100845310  DT.100031348  DT.95211011  DT.92460375  DT.87017763  DT.121082317  DT.92460374  DT.100031347 
    DT.92460371  DT.92460387  DT.100845313  DT.100845316  DT.101962776  DT.85105131  DT.92460364  DT.100845315 
    DT.121082380  DT.95076934 

    24/554 AceView cDNA sequences (see all 554 ):

    AA330556 BX282691 AV714112 AA046795 CB053722 AW276369 AA593285 BQ272162 
    AA446769 BQ549509 T40623 AI925743 BF222931 BI819539 CR609335 AA191293 
    AA723084 AA436469 BM999343 H95686 AI197793 AI240833 BM720405 AW451903 

    highest scoring ESTs for RAB31:

    AA191694 AI189226 U55978 U59877 AA027949 AA027963 AA032172 AA032173 AA040240 AA045135 

    Unigene Cluster for RAB31:

    RAB31, member RAS oncogene family
    Hs.714730  [show with all ESTs]
    Unigene Representative Sequence: NM_006868


    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for RAB31

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c
    SP1:                                      -     -                     
    SP2:        -                             -     -                     
    SP3:                                            -                     
    SP4:                                                                  

    About this scheme

    ECgene alternative splicing isoforms for RAB31

    1 Ensembl transcript including schematic representation:
    ENST00000306096  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    RAB31 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for RAB31

    1 / 2 / 3

    10 probe-sets matching RAB31 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    65819_at2, 3 U95-C 1 1.00 1.00 0.98 1.04 AA191694 1.00 1.00 1.00 1

    57154_at2, 3 U95-B 1 1.00 1.00 0.97 1.24 U55978 1.00 1.00 1.00 1
    33371_s_at2, 3 U95-A 1 1.00 1.00 0.89 0.76 U59877 1.00 1.00 1.00 1

    33372_at2, 3 U95-A 1 1.00 1.00 0.78 0.96 AI189226 1.00 1.00 1.00 1

    217764_s_at2, 3 U133-A 1 1.00 1.00 -- -- AF183421 0.80 1.00 0.91 1

    217763_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_006868 0.60 1.00 0.82 1

    217762_s_at2, 3 U133-A 1 1.00 1.00 -- -- BE789881 0.80 1.00 0.91 1

    217764_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    217763_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    217762_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  RAB31 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TATTCTATTC

    SOURCE GeneReport for Unigene cluster: Hs.714730

    Expression variation in blood from EXPOLDB for RAB31

    UniProtKB/Swiss-Prot: RAB31_HUMAN, Q13636
    Tissue specificity: Highest expression in placenta and brain with lower levels in heart and lung.
    Not detected in liver, skeletal muscle, kidney or pancreas

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for RAB31 gene from 5/7 species (see all 7 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    RAB311   -- RAB31, member RAS oncogene family 91.92(n)
    95.88(a)
    608485  XM_845517.1  XP_850610.1 
    chimpanzee
    (Pan troglodytes)
    RAB311   -- RAB31, member RAS oncogene family 100(n)
    100(a)
    468476  XM_523865.2  XP_523865.2 
    cow
    (Bos taurus)
    RAB311   -- RAB31, member RAS oncogene family 87.86(n)
    95.38(a)
    616979  NM_001076944.1  NP_001070412.1 
    rat
    (Rattus norvegicus)
    Rab311   -- RAB31, member RAS oncogene family 88.03(n)
    94.36(a)
    246324  NM_145094.2  NP_659562.2 
    mouse
    (Mus musculus)
    Rab311, 5 175
    RAB31, member RAS oncogene family1, 5 88.32(n)1
    94.33(a)1
    1065721  NM_133685.11  NP_598446.11 
     AA1033185  AB2326175  (see all 20)
    About this table        Species with no ortholog for RAB31

    ENSEMBL Gene Tree for RAB31
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for RAB31 gene
    RAB242  RAB22A2  

    Pseudogenes
    1 related pseudogene


    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/593 NCBI SNPs in RAB31 are shown (see all 593 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 386)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 18 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs4719711,2
    A,C,F,H9850781(-) TTTGCA/GATATA 1 -- ut31 ese35Minor allele frequency- G:0.28MN EU EA WA 596
    rs5275751,2
    A,C,F,H9852138(-) CCACAT/AGCCAA 1 -- ut315Minor allele frequency- A:0.16MN EU EA WA 596
    rs5577061,2
    A,C,F,H9851155(-) TGCAAG/CTCAGC 1 -- ut31 ese313Minor allele frequency- C:0.26MN EU EA WA 1440
    rs72320161,2
    A,C,F,H9764423(+) CTCCAT/ATGCTT 1 -- ng5111Minor allele frequency- A:0.06EU EA WA NA 976
    --
    rs6401731,2
    A,C,F,H9852822(-) AACTCT/CGTTTT 1 -- ng319Minor allele frequency- C:0.30MN EU EA WA 1012
    rs10655441,2
    C,F,H,O9849998(+) AATTAT/CTGCAT 1 -- ut31 ese39Minor allele frequency- C:0.47MN EU EA WA 1020
    rs47988511,2
    A,C,F,H9763437(+) TTCAGA/GACGCC 1 -- ng517Minor allele frequency- G:0.45EU EA NA 662
    --
    rs47988751,2
    A,C,F,H9852794(+) TCACTG/ATCATG 1 -- ng313Minor allele frequency- A:0.48EU EA 300
    --
    rs10655601,2
    A,C,F,H9850535(+) AAAGCG/ATGGAA 1 -- ut315Minor allele frequency- A:0.39MN EU EA WA 596
    rs5209861,2
    A,C,F9852877(-) ACAGGA/CCACTA 1 -- ng311Minor allele frequency- C:0.17MN 184
    About this table

    HapMap Linkage Disequilibrium images for RAB31 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 605694

    1 PharmGKB disease relationship for RAB31 gene
    Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
    Leukemia, Lymphocytic, Acute, L1PD  FA  GN  12704389
    About this table

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/16 PubMed articles for RAB31 gene (see all 16 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 11031 HGNC: 9771 AceView: RAB31 Ensembl:ENSG00000168461 euGenes: HUgn11031
    ECgene: RAB31 H-InvDB: RAB31
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for RAB31 Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for RAB31:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for RAB31-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for RAB31 Antibodies for RAB31
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for RAB31 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
     Antibodies   Primer Pairs  
     Cell Culture Products   ELISAs  
     Flow Cytometry Kits   Protease Activity Assays & Reagents  
     Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
     Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
     Recombinant & Natural Proteins  

     Recombinant Proteins (RAB31)
     Antibodies (RAB31)
     Chimera RNAi (RAB31)
     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
     Search for Antibodies & Assays

     Recombinant Proteins
    (RAB31)
     Antibodies (RAB31)
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     Search Tocris compounds for RAB31




     Drugs for RAB31
     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for RAB31

    GeneCards Homepage    -    Last full update: 2 Jul 2009        Incremental update: 13 Oct 2009

    Random Gene From GIFtS : about GIFtS

    Gene Index:   3   5   A   B   C   D   E   F   G   H   I   J   K   L   M   N   O   P   Q   R   S   T   U   V   W   X   Y   Z

    Developed at the Crown Human Genome Center & Weizmann Institute of Science



    The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
    RAB31 Gene at Home site.
    Version 2.41.1
    server5.xennexinc.com