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Aliases for RAB31 Gene

Aliases for RAB31 Gene

  • RAB31, Member RAS Oncogene Family 2 3 5
  • Ras-Related Protein Rab-22B 3 4
  • Rab22B 3 4

External Ids for RAB31 Gene

Previous GeneCards Identifiers for RAB31 Gene

  • GC18P009925
  • GC18P009764
  • GC18P009699
  • GC18P009700

Summaries for RAB31 Gene

Entrez Gene Summary for RAB31 Gene

  • Small GTP-binding proteins of the RAB family, such as RAB31, play essential roles in vesicle and granule targeting (Bao et al., 2002 [PubMed 11784320]).[supplied by OMIM, Jul 2009]

GeneCards Summary for RAB31 Gene

RAB31 (RAB31, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Endocytosis and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB5C.

UniProtKB/Swiss-Prot for RAB31 Gene

  • The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Plays a role in M6PR transport from the trans-Golgi network to endosomes. Plays a role in the internalization of EGFR from the cell membrane into endosomes. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.

Gene Wiki entry for RAB31 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB31 Gene

Genomics for RAB31 Gene

Regulatory Elements for RAB31 Gene

Promoters for RAB31 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RAB31 on UCSC Golden Path with GeneCards custom track

Genomic Location for RAB31 Gene

Chromosome:
18
Start:
9,708,165 bp from pter
End:
9,862,556 bp from pter
Size:
154,392 bases
Orientation:
Plus strand

Genomic View for RAB31 Gene

Genes around RAB31 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB31 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB31 Gene

Proteins for RAB31 Gene

  • Protein details for RAB31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13636-RAB31_HUMAN
    Recommended name:
    Ras-related protein Rab-31
    Protein Accession:
    Q13636
    Secondary Accessions:
    • B2RBT7
    • Q15770
    • Q9HC00

    Protein attributes for RAB31 Gene

    Size:
    194 amino acids
    Molecular mass:
    21569 Da
    Quaternary structure:
    • Interacts with OCRL. Interacts with NGFR (By similarity). Interacts (in GDP-bound form) with RIN3 and GAPVD1, which function as guanine exchange factors (GEF). Interacts (in GTP-bound form) with EEA1. Interacts with EGFR.
    SequenceCaution:
    • Sequence=AAG09690.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH01148.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RAB31 Gene

neXtProt entry for RAB31 Gene

Proteomics data for RAB31 Gene at MOPED

Post-translational modifications for RAB31 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB31 Gene

Antibody Products

No data available for DME Specific Peptides for RAB31 Gene

Domains & Families for RAB31 Gene

Gene Families for RAB31 Gene

Suggested Antigen Peptide Sequences for RAB31 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13636

UniProtKB/Swiss-Prot:

RAB31_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB31: view

Function for RAB31 Gene

Molecular function for RAB31 Gene

GENATLAS Biochemistry:
RAB31,RAS oncogene superfamily member,predominantly expressed in melanocytes
UniProtKB/Swiss-Prot Function:
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Plays a role in M6PR transport from the trans-Golgi network to endosomes. Plays a role in the internalization of EGFR from the cell membrane into endosomes. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.
genes like me logo Genes that share phenotypes with RAB31: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB31 Gene

Localization for RAB31 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB31 Gene

Golgi apparatus, trans-Golgi network. Golgi apparatus, trans-Golgi network membrane; Lipid-anchor; Cytoplasmic side. Early endosome. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Note=Rapidly recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211). {ECO:0000269 PubMed:21255211}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB31 Gene COMPARTMENTS Subcellular localization image for RAB31 gene
Compartment Confidence
endosome 5
golgi apparatus 5
cytosol 3
extracellular 1
lysosome 1
mitochondrion 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for RAB31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005802 trans-Golgi network IEA --
genes like me logo Genes that share ontologies with RAB31: view

Pathways & Interactions for RAB31 Gene

genes like me logo Genes that share pathways with RAB31: view

Pathways by source for RAB31 Gene

1 KEGG pathway for RAB31 Gene
1 Qiagen pathway for RAB31 Gene

Interacting Proteins for RAB31 Gene

Selected Interacting proteins: Q13636-RAB31_HUMAN for RAB31 Gene via MINT I2D

Gene Ontology (GO) - Biological Process for RAB31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IEA --
GO:0006913 nucleocytoplasmic transport IEA --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0031623 receptor internalization IMP 19725050
GO:0032869 cellular response to insulin stimulus IMP 17189207
genes like me logo Genes that share ontologies with RAB31: view

No data available for SIGNOR curated interactions for RAB31 Gene

Drugs & Compounds for RAB31 Gene

No Compound Related Data Available

Transcripts for RAB31 Gene

Unigene Clusters for RAB31 Gene

RAB31, member RAS oncogene family:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB31 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c
SP1: - -
SP2: - - -
SP3: -
SP4:

Relevant External Links for RAB31 Gene

GeneLoc Exon Structure for
RAB31
ECgene alternative splicing isoforms for
RAB31

Expression for RAB31 Gene

mRNA expression in normal human tissues for RAB31 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RAB31 Gene

This gene is overexpressed in Bone (8.4), Peripheral blood mononuclear cells (8.0), and Tlymphocyte (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for RAB31 Gene



SOURCE GeneReport for Unigene cluster for RAB31 Gene Hs.744887

mRNA Expression by UniProt/SwissProt for RAB31 Gene

Q13636-RAB31_HUMAN
Tissue specificity: Highest expression in placenta and brain with lower levels in heart and lung. Not detected in liver, skeletal muscle, kidney or pancreas.
genes like me logo Genes that share expression patterns with RAB31: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for RAB31 Gene

Orthologs for RAB31 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAB31 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB31 35
  • 100 (n)
  • 100 (a)
RAB31 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RAB31 36
  • 90 (a)
OneToOne
RAB31 35
  • 87.86 (n)
  • 95.38 (a)
dog
(Canis familiaris)
Mammalia RAB31 35
  • 91.97 (n)
  • 95.9 (a)
RAB31 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rab31 16
Rab31 36
  • 94 (a)
OneToOne
Rab31 35
  • 88.38 (n)
  • 94.36 (a)
oppossum
(Monodelphis domestica)
Mammalia RAB31 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAB31 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rab31 35
  • 88.03 (n)
  • 94.36 (a)
chicken
(Gallus gallus)
Aves RAB31 35
  • 83.15 (n)
  • 93.41 (a)
RAB31 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAB31 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rab31 35
  • 76.12 (n)
  • 88.66 (a)
zebrafish
(Danio rerio)
Actinopterygii RAB31 36
  • 81 (a)
OneToOne
LOC568800 35
  • 72.34 (n)
  • 80.93 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS21 36
  • 41 (a)
ManyToMany
YPT53 36
  • 37 (a)
ManyToMany
Species with no ortholog for RAB31:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAB31 Gene

ENSEMBL:
Gene Tree for RAB31 (if available)
TreeFam:
Gene Tree for RAB31 (if available)

Paralogs for RAB31 Gene

Pseudogenes.org Pseudogenes for RAB31 Gene

genes like me logo Genes that share paralogs with RAB31: view

Variants for RAB31 Gene

Sequence variations from dbSNP and Humsavar for RAB31 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs7265 -- 9,862,144(+) GCATG(C/T)GGTGG utr-variant-3-prime
rs497146 -- 9,853,760(-) tccca(C/T)tttta intron-variant
rs547835 -- 9,855,617(-) CAAAC(C/G)CCGAA intron-variant
rs549440 -- 9,862,067(-) TCCAT(C/T)GGGGC utr-variant-3-prime
rs503316 -- 9,843,667(-) ATGCT(G/T)GAGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB31 Gene

Variant ID Type Subtype PubMed ID
nsv458024 CNV Gain 19166990
nsv469897 CNV Loss 16826518
esv2716771 CNV Deletion 23290073
nsv9606 CNV Loss 18304495
dgv1010e1 CNV Complex 17122850
nsv828177 CNV Loss 20364138
nsv817783 CNV Loss 17921354
nsv909366 CNV Gain 21882294
nsv909367 CNV Loss 21882294
nsv833586 CNV Loss 17160897
esv2716772 CNV Deletion 23290073
esv2661546 CNV Deletion 23128226
esv259550 OTHER Complex 20981092
esv260000 OTHER Complex 20981092
nsv9607 CNV Loss 18304495
nsv820745 CNV Deletion 20802225
esv25767 CNV Loss 19812545
esv5001 CNV Deletion 18987735
esv2716774 CNV Deletion 23290073
esv2716775 CNV Deletion 23290073
esv999723 CNV Insertion 20482838
nsv507860 CNV Insertion 20534489

Variation tolerance for RAB31 Gene

Residual Variation Intolerance Score: 55.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.38; 8.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAB31 Gene

HapMap Linkage Disequilibrium report
RAB31

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB31 Gene

Disorders for RAB31 Gene

Relevant External Links for RAB31

Genetic Association Database (GAD)
RAB31
Human Genome Epidemiology (HuGE) Navigator
RAB31
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAB31
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAB31

No disorders were found for RAB31 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB31 Gene

Publications for RAB31 Gene

  1. Molecular cloning of two novel rab genes from human melanocytes. (PMID: 8863739) Chen D. … Gahl W.A. (Gene 1996) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia. (PMID: 24954895) Simino J. … Rao D.C. (Am. J. Hum. Genet. 2014) 3
  4. Engagement of the small GTPase Rab31 protein and its effector, early endosome antigen 1, is important for trafficking of the ligand-bound epidermal growth factor receptor from the early to the late endosome. (PMID: 24644286) Chua C.E. … Tang B.L. (J. Biol. Chem. 2014) 3
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3

Products for RAB31 Gene

Sources for RAB31 Gene

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