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Aliases for RAB31 Gene

Aliases for RAB31 Gene

  • RAB31, Member RAS Oncogene Family 2 3
  • Ras-Related Protein Rab-22B 3 4
  • Rab22B 3 4
  • Ras-Related Protein Rab-31 3

External Ids for RAB31 Gene

Summaries for RAB31 Gene

Entrez Gene Summary for RAB31 Gene

  • Small GTP-binding proteins of the RAB family, such as RAB31, play essential roles in vesicle and granule targeting (Bao et al., 2002 [PubMed 11784320]).[supplied by OMIM, Jul 2009]

GeneCards Summary for RAB31 Gene

RAB31 (RAB31, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Endocytosis and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB5C.

UniProtKB/Swiss-Prot for RAB31 Gene

  • The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Plays a role in M6PR transport from the trans-Golgi network to endosomes. Plays a role in the internalization of EGFR from the cell membrane into endosomes. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.

Gene Wiki entry for RAB31 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB31 Gene

Genomics for RAB31 Gene

Genomic Location for RAB31 Gene

Start:
9,708,165 bp from pter
End:
9,862,556 bp from pter
Size:
154,392 bases
Orientation:
Plus strand

Genomic View for RAB31 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAB31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB31 Gene

Proteins for RAB31 Gene

  • Protein details for RAB31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13636-RAB31_HUMAN
    Recommended name:
    Ras-related protein Rab-31
    Protein Accession:
    Q13636
    Secondary Accessions:
    • B2RBT7
    • Q15770
    • Q9HC00

    Protein attributes for RAB31 Gene

    Size:
    194 amino acids
    Molecular mass:
    21569 Da
    Quaternary structure:
    • Interacts with OCRL. Interacts with NGFR (By similarity). Interacts (in GDP-bound form) with RIN3 and GAPVD1, which function as guanine exchange factors (GEF). Interacts (in GTP-bound form) with EEA1. Interacts with EGFR.
    SequenceCaution:
    • Sequence=AAG09690.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH01148.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RAB31 Gene

neXtProt entry for RAB31 Gene

Proteomics data for RAB31 Gene at MOPED

Post-translational modifications for RAB31 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB31 Gene

No data available for DME Specific Peptides for RAB31 Gene

Domains for RAB31 Gene

Gene Families for RAB31 Gene

HGNC:
  • RAB :RAB, member RAS oncogene

UniProtKB/Swiss-Prot:

RAB31_HUMAN
Family:
  • Belongs to the small GTPase superfamily. Rab family.:
    • Q13636
genes like me logo Genes that share domains with RAB31: view

Function for RAB31 Gene

Molecular function for RAB31 Gene

GENATLAS Biochemistry: RAB31,RAS oncogene superfamily member,predominantly expressed in melanocytes
UniProtKB/Swiss-Prot Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Plays a role in M6PR transport from the trans-Golgi network to endosomes. Plays a role in the internalization of EGFR from the cell membrane into endosomes. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.

Gene Ontology (GO) - Molecular Function for RAB31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity TAS 8863739
GO:0005525 GTP binding IDA 17189207
GO:0019003 GDP binding IDA 17189207
genes like me logo Genes that share ontologies with RAB31: view
genes like me logo Genes that share phenotypes with RAB31: view

miRNA for RAB31 Gene

miRTarBase miRNAs that target RAB31

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RAB31 Gene

Localization for RAB31 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB31 Gene

Golgi apparatus, trans-Golgi network. Golgi apparatus, trans-Golgi network membrane; Lipid-anchor; Cytoplasmic side. Early endosome. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Note=Rapidly recruited to phagosomes containing S.aureus or M.tuberculosis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB31 Gene COMPARTMENTS Subcellular localization image for RAB31 gene
Compartment Confidence
endosome 5
cytosol 3
golgi apparatus 3
extracellular 1
lysosome 1
mitochondrion 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for RAB31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005737 cytoplasm --
GO:0005769 early endosome IDA 17189207
GO:0005770 late endosome IEA --
genes like me logo Genes that share ontologies with RAB31: view

Pathways for RAB31 Gene

genes like me logo Genes that share pathways with RAB31: view

Pathways by source for RAB31 Gene

1 Qiagen pathway for RAB31 Gene
1 KEGG pathway for RAB31 Gene

Interacting Proteins for RAB31 Gene

Selected Interacting proteins: Q13636-RAB31_HUMAN for RAB31 Gene via MINT I2D

Gene Ontology (GO) - Biological Process for RAB31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport --
GO:0006913 nucleocytoplasmic transport --
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction --
genes like me logo Genes that share ontologies with RAB31: view

Transcripts for RAB31 Gene

mRNA/cDNA for RAB31 Gene

Unigene Clusters for RAB31 Gene

RAB31, member RAS oncogene family:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAB31 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c
SP1: - -
SP2: - - -
SP3: -
SP4:

Relevant External Links for RAB31 Gene

GeneLoc Exon Structure for
RAB31
ECgene alternative splicing isoforms for
RAB31

Expression for RAB31 Gene

mRNA expression in normal human tissues for RAB31 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for RAB31 Gene

SOURCE GeneReport for Unigene cluster for RAB31 Gene Hs.744887

mRNA Expression by UniProt/SwissProt for RAB31 Gene

Q13636-RAB31_HUMAN
Tissue specificity: Highest expression in placenta and brain with lower levels in heart and lung. Not detected in liver, skeletal muscle, kidney or pancreas.
genes like me logo Genes that share expressions with RAB31: view

Orthologs for RAB31 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAB31 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB31 36
  • 100 (n)
  • 100 (a)
RAB31 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RAB31 36
  • 87.86 (n)
  • 95.38 (a)
RAB31 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAB31 36
  • 91.97 (n)
  • 95.9 (a)
RAB31 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rab31 36
  • 88.38 (n)
  • 94.36 (a)
Rab31 16
Rab31 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAB31 37
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAB31 37
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rab31 36
  • 88.03 (n)
  • 94.36 (a)
chicken
(Gallus gallus)
Aves RAB31 36
  • 83.15 (n)
  • 93.41 (a)
RAB31 37
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAB31 37
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rab31 36
  • 76.12 (n)
  • 88.66 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC568800 36
  • 72.34 (n)
  • 80.93 (a)
RAB31 37
  • 81 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS21 37
  • 41 (a)
ManyToMany
YPT53 37
  • 37 (a)
ManyToMany
Species with no ortholog for RAB31:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAB31 Gene

ENSEMBL:
Gene Tree for RAB31 (if available)
TreeFam:
Gene Tree for RAB31 (if available)

Paralogs for RAB31 Gene

Pseudogenes.org Pseudogenes for RAB31 Gene

genes like me logo Genes that share paralogs with RAB31: view

Variants for RAB31 Gene

Sequence variations from dbSNP and Humsavar for RAB31 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs2996 -- 9,860,161(-) TGTGC(C/G)TTAAA utr-variant-3-prime
rs7265 -- 9,862,144(+) GCATG(C/T)GGTGG utr-variant-3-prime
rs9721 -- 9,860,876(-) TGAAC(C/T)CTCTT utr-variant-3-prime
rs13611 -- 9,862,075(-) ACTCA(G/T)TTTCC utr-variant-3-prime
rs471971 -- 9,860,784(-) TTTGC(A/G)ATATA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RAB31 Gene

Variant ID Type Subtype PubMed ID
nsv458024 CNV Gain 19166990
nsv469897 CNV Loss 16826518
esv2716771 CNV Deletion 23290073
nsv9606 CNV Loss 18304495
dgv1010e1 CNV Complex 17122850
nsv828177 CNV Loss 20364138
nsv817783 CNV Loss 17921354
nsv909366 CNV Gain 21882294
nsv909367 CNV Loss 21882294
nsv833586 CNV Loss 17160897
esv2716772 CNV Deletion 23290073
esv2661546 CNV Deletion 23128226
esv259550 OTHER Complex 20981092
esv260000 OTHER Complex 20981092
nsv9607 CNV Loss 18304495
nsv820745 CNV Deletion 20802225
esv25767 CNV Loss 19812545
esv5001 CNV Deletion 18987735
esv2716774 CNV Deletion 23290073
esv2716775 CNV Deletion 23290073
esv999723 CNV Insertion 20482838
nsv507860 CNV Insertion 20534489

Relevant External Links for RAB31 Gene

HapMap Linkage Disequilibrium report
RAB31

Disorders for RAB31 Gene

Relevant External Links for RAB31

Genetic Association Database (GAD)
RAB31
Human Genome Epidemiology (HuGE) Navigator
RAB31
genes like me logo Genes that share disorders with RAB31: view

No data available for UniProtKB/Swiss-Prot for RAB31 Gene

Publications for RAB31 Gene

  1. Molecular cloning of two novel rab genes from human melanocytes. (PMID: 8863739) Chen D. … Gahl W.A. (Gene 1996) 2 3 4
  2. Molecular cloning, bacterial expression and properties of Rab31 and Rab32. (PMID: 11784320) Bao X. … Haslam R.J. (Eur. J. Biochem. 2002) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes. (PMID: 21255211) Seto S. … Koide Y. (Traffic 2011) 3 4
  5. Characterization of RIN3 as a guanine nucleotide exchange factor for the Rab5 subfamily GTPase Rab31. (PMID: 21586568) Kajiho H. … Katada T. (J. Biol. Chem. 2011) 3 4

Products for RAB31 Gene

Sources for RAB31 Gene

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