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Aliases & Descriptions for RAB31
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| RAB22B 3 | | Rab-22B 3 | | Rab22B 1, 2 |
| | | Descriptions |
|---|
| RAB31, member RAS oncogene family 2 |
|
| | Search outside databases for aliases for RAB31 genePrevious GC identifers: GC18P009925 GC18P009764 GC18P009699 GC18P009700 |
Summaries for RAB31(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Gene Wiki entry for RAB31 |
Genomic Location for RAB31
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the RAB31 gene 
Entrez Gene cytogenetic band: 18p11.3 Ensembl cytogenetic band: 18p11.22 HGNC cytogenetic band: 18p11.3RAB31 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 18 GeneLoc Exon Structure GeneLoc location for GC18P009701:
(about GC identifiers)
Start:
|
9,764,874 bp from pter |
End:
|
9,852,548 bp from pter |
Size:
|
87,675 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000018.8 NT_010859.14
| Proteins for RAB31
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: RAB31_HUMAN, Q13636 (See
protein sequence)Recommended Name: Ras-related protein Rab-31 Size: 194 amino acids; 21569 Da
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
PDB structures from and Proteopedia :2FG5 (3D)
 
Secondary accessions: B2RBT7 Q15770 Q9HC00Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_006859.2
ENSEMBL proteins: ENSP00000304565
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: RAB31 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
IEA | -- | About this table
Antibodies for RAB31: Assays for RAB31: | Protein
Domains/ Families for RAB31(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q13636
ProtoNet protein and cluster: Q13636 1 Blocks protein family: IPB001806 Transforming protein P21 RAS signature
UniProtKB/Swiss-Prot: RAB31_HUMAN, Q13636Similarity: Belongs to the small GTPase superfamily. Rab family | Gene Function for RAB31
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006868
Applied Biosystems Silencer® siRNAs for RAB31
Sigma-Aldrich siRNA for RAB31  Sigma-Aldrich shRNA for RAB31  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006868                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006868                                  untagged cDNA clone in CMV expression vector: NM_006868 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_006868
Genatlas biochemistry entry for RAB31:RAB31,RAS oncogene superfamily member,predominantly expressed in melanocytes3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for RAB31
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
2 Interacting proteins for RAB31 (ENSP000003045653 Q136362) via UniProtKB, MINT, and/or STRINGAbout this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007264 | small GTPase mediated signal transduction |
IEA | -- | | GO:0015031 | protein transport |
IEA | -- | About this table
|
Drugs & Compounds for RAB31(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|  |
Enzo Life Sciences drugs & compounds for RAB31 |
Browse Tocris compounds for RAB31 2 PharmGKB drug compound relationships for RAB31 geneAbout this table
|
Transcripts for RAB31(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006868
Sigma-Aldrich siRNA for RAB31  Sigma-Aldrich shRNA for RAB31  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_006868 REFSEQ mRNAs for RAB31 gene: NM_006868.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_006868               OriGene GFP tagged cDNA clone in CMV expression vector: NM_006868                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006868                                  untagged cDNA clone in CMV expression vector: NM_006868  Additional cDNA sequence: AF183421.1 AF234995.1 AF498957.1 AK223505.1 AK314809.1 BC001148.1 BT020027.1 BT020028.1 CR407659.1 CR609335.1 CR623736.1 U57091.1 U59877.1 18 DOTS entries: DT.100845310 DT.100031348 DT.95211011 DT.92460375 DT.87017763 DT.121082317 DT.92460374 DT.100031347 DT.92460371 DT.92460387 DT.100845313 DT.100845316 DT.101962776 DT.85105131 DT.92460364 DT.100845315 DT.121082380 DT.95076934 24/554 AceView cDNA sequences (see all 554
):AA330556 BX282691 AV714112 AA046795 CB053722 AW276369 AA593285 BQ272162 AA446769 BQ549509 T40623 AI925743 BF222931 BI819539 CR609335 AA191293 AA723084 AA436469 BM999343 H95686 AI197793 AI240833 BM720405 AW451903
highest scoring ESTs for RAB31:AA191694 AI189226 U55978 U59877 AA027949 AA027963 AA032172 AA032173 AA040240 AA045135 Unigene Cluster for RAB31: RAB31, member RAS oncogene family Hs.714730 [show with all ESTs]Unigene Representative Sequence: NM_006868
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for RAB31
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | |
| SP1: | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |
| SP2: | |   | - |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for RAB31
1 Ensembl transcript including schematic representation: ENST00000306096
|
Expression for RAB31
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| RAB31 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for RAB31
1 / 2 / 3 10 probe-sets matching RAB31 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TATTCTATTC
SOURCE GeneReport for Unigene cluster: Hs.714730
Expression variation in blood from EXPOLDB for RAB31 UniProtKB/Swiss-Prot: RAB31_HUMAN, Q13636Tissue specificity: Highest expression in placenta and brain with lower levels in heart and lung. Not detected in liver, skeletal muscle, kidney or pancreas |
Orthologs for RAB31
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for RAB31 gene from 5/7 species (see all 7
)
About this table Species with no ortholog for RAB31
ENSEMBL Gene Tree for RAB31 | Paralogs for RAB31(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for RAB31 gene
- RAB242 RAB22A2
Pseudogenes
- 1 related pseudogene
|
SNPs/Variants for RAB31(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for RAB31 (up to first 250kb)
|
Disorders & Mutations for RAB31
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 605694
1 PharmGKB disease relationship for RAB31 geneAbout this table
|
Medical News for RAB31(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for RAB31 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/16 PubMed articles for RAB31 gene (see all 16
):- Molecular cloning of two novel rab genes from human melanocytes. (PubMed id 8863739)2, 3, 4 Chen D.... Gahl W.A. (1996)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)3, 4 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Molecular cloning, bacterial expression and properties of Rab31 and Rab32. (PubMed id 11784320)3, 4 Bao X.... Haslam R.J. (2002)
- Urokinase receptor splice variant uPAR-del4/5-associated gene expression in breast cancer: identification of rab31 as an independent prognostic factor. (PubMed id 17952591)3 Kotzsch M....Foekens J.A. (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)4 Dephoure N.... Gygi S.P. (2008)
- Rab22B's role in trans-Golgi network membrane dynamics. (PubMed id 17678623)3 Ng E.L....Tang B.L. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)3 Kimura K.... Sugano S. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)4 Ota T....Sugano S. (2004)
- Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)3 Brandenberger R.... Stanton L.W. (2004)
|
Search for RAB31
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing RAB31
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing RAB31
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RAB31(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for RAB31(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for RAB31:

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Incremental update: 13 Oct 2009
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