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RAB30 Gene

protein-coding   GIFtS: 57

GC11M082370
RAB30, member RAS oncogene family
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Descriptions
RAB30, member RAS oncogene family 2
External Ids
HGNC: 97701
Entrez Gene: 273142
UniProtKB: Q157713
Ensembl: ENSG000001375027
Search outside databases for aliases for RAB30 gene

Previous GC identifers: GC11M085019 GC11M084231 GC11M082915 GC11M082418

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the RAB30 gene  

Entrez Gene cytogenetic band: 11q12-q14   Ensembl cytogenetic band:  11q14.1   HGNC cytogenetic band: 11q12-q14

RAB30 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M082370:     (about GC identifiers)

Start:
82,370,126 bp from pter
End:
82,460,532 bp from pter
Size:
90,407 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000011.8  NT_033927.7  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: RAB30_HUMAN, Q15771 (See protein sequence)
Recommended Name: Ras-related protein Rab-30  
Size: 203 amino acids; 23058 Da
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
PDB structures from and Proteopedia :
2EW1 (3D)    
Secondary accessions: Q6FGK1 Q96CI8

REFSEQ proteins: NP_055303.2  

ENSEMBL proteins: 
ENSP00000260056 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Sigma-Aldrich AQUA Peptides for RAB30  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (RAB30)
Human Recombinant Proteins from Abnova (RAB30)
              OriGene Purified Recombinant Human Protein: RAB30 

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005795 Golgi stack TAS9792283
GO:0005886 plasma membrane IEA--
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Antibodies for RAB30: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for RAB30
Browse R&D Systems for Antibodies
Antibodies from Abcam (RAB30), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (RAB30)
Novus Biologicals Antibody for RAB30

Assays for RAB30: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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4 InterPro domains/families:
 IPR001806 Ras_GTPase
 IPR005225 Small_GTP_bd
 IPR003579 GTPase_Rab
 IPR013753 Ras


   GeneDecks  RAB30 for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry Q15771

ProtoNet protein and cluster: Q15771

1 Blocks protein family: IPB001806 Transforming protein P21 RAS signature

UniProtKB/Swiss-Prot: RAB30_HUMAN, Q15771
Similarity: Belongs to the small GTPase superfamily. Rab family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (RAB30)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014488

              Applied Biosystems Silencer® siRNAs for RAB30

              Sigma-Aldrich siRNA for RAB30  
                     Sigma-Aldrich shRNA for RAB30  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_014488
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_014488
                                 untagged cDNA clone in CMV expression vector: NM_014488 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_014488

Genatlas biochemistry entry for RAB30:
RAB30, member RAS oncogene family
1 MGI phenotypic allele for Rab30 (no phenotypes)

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0000166 nucleotide binding IEA--
GO:0003924 GTPase activity TAS9792283
GO:0005525 GTP binding IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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  --

2 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA--
GO:0015031 protein transport IEA--
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for RAB30
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for RAB30

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (RAB30)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014488

              Sigma-Aldrich siRNA for RAB30  
                     Sigma-Aldrich shRNA for RAB30  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_014488  

REFSEQ mRNAs for RAB30 gene: 

NM_014488.3   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_014488  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_014488
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_014488
                                 untagged cDNA clone in CMV expression vector: NM_014488 

Additional cDNA sequence: 

AF498956.1 AK291376.1 AK310082.1 AK312323.1 BC014213.2 BX641138.1 CR542106.1 CR608213.1 
U57092.1 

10 DOTS entries:

DT.311673  DT.439103  DT.120736034  DT.91740660  DT.95298172  DT.120735971  DT.120735993  DT.120736002 
DT.120736038  DT.99960914 

24/80 AceView cDNA sequences (see all 80 ):

AI218306 AA452213 NM_014488 BF516253 AI583217 BC014213 AA455321 AW181898 
AI096732 CR542106 AI095008 BF513724 AA288001 AI423008 AI673455 H97237 
CR608213 AA748695 AF498956 BP351657 AA455976 AI423270 U57092 AW292987 

highest scoring ESTs for RAB30:

AI218306 AI420336 U57092 BC014213 BG686927 BI758014 BI910978 BX641138 CF135881 AA159679 

Unigene Cluster for RAB30:

RAB30, member RAS oncogene family
Hs.40758  [show with all ESTs]
Unigene Representative Sequence: BX641138


GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for RAB30 (see all 12 )

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b · 10c · 10d · 10e ·
SP1:                    -     -     -     -     -                 -     -     -                       -                 -     -                                 
SP2:                    -     -     -           -                 -     -     -                                                                                 
SP3:                    -     -     -     -     -     -     -     -     -     -                       -                 -     -                                 
SP4:                          -     -     -     -     -     -     -     -     -                       -                 -     -                                 
SP5:                                            -                 -     -     -                                                                                 

ExUns: 10f
SP1:      
SP2:      
SP3:      
SP4:      
SP5:      

About this scheme

ECgene alternative splicing isoforms for RAB30

1 Ensembl transcript including schematic representation:
ENST00000260056  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

RAB30 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for RAB30

1 / 2 / 3

9 probe-sets matching RAB30 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

807_at2, 3 U95-A 1 1.00 1.00 0.86 0.58 U57092 0.80 1.00 0.91 1

33599_at2, 3 U95-A 1 1.00 1.00 0.23 0.19 U57092 0.80 1.00 0.91 1
58691_at2, 3 U95-B 1 1.00 1.00 0.87 1.13 AI420336 0.80 1.00 0.91 1

58693_g_at2, 3 U95-B 1 1.00 1.00 0.94 1.29 AI420336 0.80 1.00 0.91 1
51028_at2, 3 U95-B 2 0.81 0.96 0.88 1.03 AI218306 0.80 1.00 0.91 1

228003_at2, 3 U133-B 1 1.00 1.00 -- -- AW294640 0.60 1.00 0.82 1

206530_at2, 3 U133-A 1 1.00 1.00 -- -- NM_014488 0.60 1.00 0.82 1

228003_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

206530_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  RAB30 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: AATCAGCAAA

SOURCE GeneReport for Unigene cluster: Hs.40758

Expression variation in blood from EXPOLDB for RAB30

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for RAB30 gene from 5/12 species (see all 12 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
RAB301   -- RAB30, member RAS oncogene family 96.22(n)
100(a)
476787  XM_533993.2  XP_533993.1 
chimpanzee
(Pan troglodytes)
RAB301   -- RAB30, member RAS oncogene family 100(n)
100(a)
749006  XM_001175166.1  XP_001175166.1 
cow
(Bos taurus)
RAB301   -- RAB30, member RAS oncogene family 95.57(n)
100(a)
540583  NM_001076229.1  NP_001069697.1 
rat
(Rattus norvegicus)
Rab301   -- RAB30, member RAS oncogene family 93.71(n)
100(a)
308821  NM_001015012.1  NP_001015012.1 
mouse
(Mus musculus)
Rab301, 5 75
RAB30, member RAS oncogene family1, 5 94.09(n)1
100(a)1
759851  NM_029494.21  NP_083770.21 
 AB2326265  AF3997565  (see all 12)
About this table        Species with no ortholog for RAB30

ENSEMBL Gene Tree for RAB30
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for RAB30 gene
RAB192  RAB432  ENSG000001850512  

Pseudogenes
1 related pseudogene


(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/443 NCBI SNPs in RAB30 are shown (see all 443 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 191)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 11 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs37638121,2
C,F,H82461462(-) CTTTCG/ACTGGT 1 -- ng318Minor allele frequency- A:0.16NA EU EA WA 630
rs116016101,2
C,F,H82370170(+) TAACAC/AATTTA 1 -- ut3110Minor allele frequency- A:0.03EU EA WA NA 1020
rs79271591,2
F,H82462208(+) GCAGAT/CAGAAT 1 -- ng31 tfbs34Minor allele frequency- C:0.01EU EA WA 418
rs112334001,2
C,H82376294(+) TGATGA/CCCTTG 1 V/G mis1 ese38Minor allele frequency- C:0.00EU EA WA 836
rs171444531,2
F,H82369779(+) CCTAAG/ACCTTG 1 -- ng517Minor allele frequency- A:0.05NA EU EA WA 560
rs127971621,2
F,H82460523(+) TTAGCT/CCAGCT 1 -- ut51 ese33Minor allele frequency- C:0.03EA WA 278
rs284114021,2
F82460422(-) ATCCAT/GTTCTG 1 -- ut51 ese32Minor allele frequency- G:0.02MN EA 1252
rs128020951,2
F82460626(+) CTCTGT/CCCAAA 1 -- ng312Minor allele frequency- C:0.22MN EA 1252
rs19044281,2
A,C,F,H,O82395900(+) CTGCAC/AATATA 1 -- int111Minor allele frequency- A:0.47NA EU EA WA 982
rs18939361,2
A,C,F,H,O82441220(-) CTGTTA/CAGTTC 1 -- int111Minor allele frequency- C:0.19NA EU EA WA 918
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HapMap Linkage Disequilibrium images for RAB30 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 605693

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

6 PubMed articles for RAB30 gene:
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 27314 HGNC: 9770 AceView: RAB30 Ensembl:ENSG00000137502 euGenes: HUgn27314
ECgene: RAB30 H-InvDB: RAB30
(According to HUGE)
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  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

NameDescription
ATLAS Chromosomes in Cancer entry for RAB30 Genetics and Cytogenetics in Oncology and Haematology
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for RAB30:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for RAB30-related products

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 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for RAB30 Antibodies for RAB30
 Explore super-pooled esiRNAs Proteins for RAB30
 Lentivirus-delivered shRNAs for RAB30 Browse small molecules at Sigma-Aldrich
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 Recombinant & Natural Proteins  

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 Recombinant Proteins
(RAB30)
 Antibodies (RAB30)
 Tagged/untagged cDNA clones
 Validated SYBR primer pairs
 Purified proteins from HEK293T cells
 Western blot validated antibodies
 shRNA in GFP-retroviral vector
 Search Tocris compounds for RAB30




 Drugs for RAB30
 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for RAB30

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