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Aliases for RAB30 Gene

Aliases for RAB30 Gene

  • RAB30, Member RAS Oncogene Family 2 3

External Ids for RAB30 Gene

Previous GeneCards Identifiers for RAB30 Gene

  • GC11M085019
  • GC11M084231
  • GC11M082915
  • GC11M082418
  • GC11M082370
  • GC11M082692
  • GC11M078989

Summaries for RAB30 Gene

GeneCards Summary for RAB30 Gene

RAB30 (RAB30, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB42.

UniProtKB/Swiss-Prot for RAB30 Gene

  • The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Required for maintaining the structural integrity of the Golgi apparatus, possibly by mediating interactions with cytoplasmic scaffolding proteins.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB30 Gene

Genomics for RAB30 Gene

Regulatory Elements for RAB30 Gene

Genomic Location for RAB30 Gene

Start:
82,973,133 bp from pter
End:
83,071,923 bp from pter
Size:
98,791 bases
Orientation:
Minus strand

Genomic View for RAB30 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAB30 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB30 Gene

Proteins for RAB30 Gene

  • Protein details for RAB30 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15771-RAB30_HUMAN
    Recommended name:
    Ras-related protein Rab-30
    Protein Accession:
    Q15771
    Secondary Accessions:
    • Q6FGK1
    • Q6MZH2
    • Q96CI8

    Protein attributes for RAB30 Gene

    Size:
    203 amino acids
    Molecular mass:
    23058 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RAB30 Gene

    Alternative splice isoforms for RAB30 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAB30 Gene

Proteomics data for RAB30 Gene at MOPED

Post-translational modifications for RAB30 Gene

  • Ubiquitination at Lys59
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RAB30 Gene

Domains for RAB30 Gene

Gene Families for RAB30 Gene

HGNC:
  • RAB :RAB, member RAS oncogene

Suggested Antigen Peptide Sequences for RAB30 Gene

Graphical View of Domain Structure for InterPro Entry

Q15771

UniProtKB/Swiss-Prot:

RAB30_HUMAN :
  • Q15771
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB30: view

Function for RAB30 Gene

Molecular function for RAB30 Gene

GENATLAS Biochemistry:
RAB30, member RAS oncogene family
UniProtKB/Swiss-Prot Function:
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Required for maintaining the structural integrity of the Golgi apparatus, possibly by mediating interactions with cytoplasmic scaffolding proteins.

Gene Ontology (GO) - Molecular Function for RAB30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity TAS 9792283
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RAB30: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAB30

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RAB30 Gene

Localization for RAB30 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB30 Gene

Membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus, trans-Golgi network. Cytoplasm. Golgi apparatus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB30 Gene COMPARTMENTS Subcellular localization image for RAB30 gene
Compartment Confidence
golgi apparatus 5
cytosol 3
cytoskeleton 2
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RAB30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005737 cytoplasm IDA --
GO:0005795 Golgi stack TAS 9792283
GO:0005801 cis-Golgi network IDA 22188167
genes like me logo Genes that share ontologies with RAB30: view

Pathways for RAB30 Gene

genes like me logo Genes that share pathways with RAB30: view

Pathways by source for RAB30 Gene

1 Qiagen pathway for RAB30 Gene

Interacting Proteins for RAB30 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000260056%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000295822%0d%0a
Selected Interacting proteins: ENSP00000260056 Q15771-RAB30_HUMAN for RAB30 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for RAB30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport IBA --
GO:0006913 nucleocytoplasmic transport --
GO:0007030 Golgi organization IMP 22188167
GO:0007165 signal transduction --
genes like me logo Genes that share ontologies with RAB30: view

Transcripts for RAB30 Gene

Unigene Clusters for RAB30 Gene

RAB30, member RAS oncogene family:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAB30

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB30 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b · 10c · 10d · 10e ·
SP1: - - - - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - - - -
SP6: - - - - -
SP7: - - - - - - - -
SP8: - - -
SP9: - - -
SP10: -
SP11: - -
SP12: - - -

ExUns: 10f
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for RAB30 Gene

GeneLoc Exon Structure for
RAB30
ECgene alternative splicing isoforms for
RAB30

Expression for RAB30 Gene

mRNA expression in normal human tissues for RAB30 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for RAB30 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (31.9), Brain (10.5), and Plasma (8.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB30 Gene

SOURCE GeneReport for Unigene cluster for RAB30 Gene Hs.40758

genes like me logo Genes that share expressions with RAB30: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for RAB30 Gene

Orthologs for RAB30 Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB30 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RAB30 35
  • 95.57 (n)
  • 100 (a)
RAB30 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAB30 35
  • 96.22 (n)
  • 100 (a)
RAB30 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rab30 35
  • 94.09 (n)
  • 100 (a)
Rab30 16
Rab30 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RAB30 35
  • 100 (n)
  • 100 (a)
RAB30 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rab30 35
  • 93.71 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia RAB30 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAB30 36
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAB30 35
  • 85.39 (n)
  • 98.52 (a)
RAB30 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAB30 36
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rab30 35
  • 80.95 (n)
  • 93.1 (a)
zebrafish
(Danio rerio)
Actinopterygii rab30 35
  • 76.29 (n)
  • 85.57 (a)
rab30 36
  • 86 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG2885 37
  • 36 (a)
CG9100 37
  • 73 (a)
Rab-RP3 37
  • 48 (a)
Rab30 35
  • 64.22 (n)
  • 69.11 (a)
Rab30 36
  • 60 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002092 35
  • 60.44 (n)
  • 65.66 (a)
worm
(Caenorhabditis elegans)
Secernentea rab-30 35
  • 60.5 (n)
  • 63.58 (a)
rab-30 36
  • 53 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13245 35
Species with no ortholog for RAB30:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB30 Gene

ENSEMBL:
Gene Tree for RAB30 (if available)
TreeFam:
Gene Tree for RAB30 (if available)

Paralogs for RAB30 Gene

genes like me logo Genes that share paralogs with RAB30: view

Variants for RAB30 Gene

Sequence variations from dbSNP and Humsavar for RAB30 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs948182 -- 83,035,189(-) ATTAG(A/G/T)TAGAC upstream-variant-2KB, intron-variant
rs948183 -- 83,011,258(+) TTTCC(C/T)ATGTA intron-variant
rs948184 -- 83,011,617(+) AACAA(A/G)AAGAT intron-variant
rs1011618 -- 82,980,008(-) CAAGT(G/T)TGTTG utr-variant-3-prime
rs1060296 -- 82,975,590(-) ATCTC(A/G)GTTTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RAB30 Gene

Variant ID Type Subtype PubMed ID
esv33531 CNV Loss 17666407
nsv515868 CNV Gain 19592680
nsv414 CNV Insertion 18451855

Relevant External Links for RAB30 Gene

HapMap Linkage Disequilibrium report
RAB30

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB30 Gene

Disorders for RAB30 Gene

No disorders were found for RAB30 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for RAB30 Gene

Publications for RAB30 Gene

  1. Molecular cloning of two novel rab genes from human melanocytes. (PMID: 8863739) Chen D. … Gahl W.A. (Gene 1996) 2 3 4
  2. Small GTP-binding proteins in human endothelial cells. (PMID: 9792283) de Leeuw H.P. … Voorberg J. (Br. J. Haematol. 1998) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Rab30 is required for the morphological integrity of the Golgi apparatus. (PMID: 22188167) Kelly E.E. … McCaffrey M.W. (Biol. Cell 2012) 3 4
  5. The genetic architecture of economic and political preferences. (PMID: 22566634) Benjamin D.J. … Visscher P.M. (Proc. Natl. Acad. Sci. U.S.A. 2012) 3

Products for RAB30 Gene

Sources for RAB30 Gene

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