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Aliases for RAB30 Gene

Aliases for RAB30 Gene

  • RAB30, Member RAS Oncogene Family 2 3 5

External Ids for RAB30 Gene

Previous GeneCards Identifiers for RAB30 Gene

  • GC11M085019
  • GC11M084231
  • GC11M082915
  • GC11M082418
  • GC11M082370
  • GC11M082692
  • GC11M078989

Summaries for RAB30 Gene

GeneCards Summary for RAB30 Gene

RAB30 (RAB30, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Golgi-to-ER retrograde transport. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB33A.

UniProtKB/Swiss-Prot for RAB30 Gene

  • The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Required for maintaining the structural integrity of the Golgi apparatus, possibly by mediating interactions with cytoplasmic scaffolding proteins.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB30 Gene

Genomics for RAB30 Gene

Regulatory Elements for RAB30 Gene

Enhancers for RAB30 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RAB30 on UCSC Golden Path with GeneCards custom track

Promoters for RAB30 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RAB30 on UCSC Golden Path with GeneCards custom track

Genomic Location for RAB30 Gene

Chromosome:
11
Start:
82,973,133 bp from pter
End:
83,071,923 bp from pter
Size:
98,791 bases
Orientation:
Minus strand

Genomic View for RAB30 Gene

Genes around RAB30 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB30 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB30 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB30 Gene

Proteins for RAB30 Gene

  • Protein details for RAB30 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15771-RAB30_HUMAN
    Recommended name:
    Ras-related protein Rab-30
    Protein Accession:
    Q15771
    Secondary Accessions:
    • Q6FGK1
    • Q6MZH2
    • Q96CI8

    Protein attributes for RAB30 Gene

    Size:
    203 amino acids
    Molecular mass:
    23058 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RAB30 Gene

    Alternative splice isoforms for RAB30 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAB30 Gene

Proteomics data for RAB30 Gene at MOPED

Post-translational modifications for RAB30 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RAB30 Gene

Domains & Families for RAB30 Gene

Gene Families for RAB30 Gene

Suggested Antigen Peptide Sequences for RAB30 Gene

Graphical View of Domain Structure for InterPro Entry

Q15771

UniProtKB/Swiss-Prot:

RAB30_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB30: view

Function for RAB30 Gene

Molecular function for RAB30 Gene

GENATLAS Biochemistry:
RAB30, member RAS oncogene family
UniProtKB/Swiss-Prot Function:
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Required for maintaining the structural integrity of the Golgi apparatus, possibly by mediating interactions with cytoplasmic scaffolding proteins.
genes like me logo Genes that share phenotypes with RAB30: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RAB30

miRNA for RAB30 Gene

miRTarBase miRNAs that target RAB30

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB30 Gene

Localization for RAB30 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB30 Gene

Membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus, trans-Golgi network. Cytoplasm. Golgi apparatus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB30 Gene COMPARTMENTS Subcellular localization image for RAB30 gene
Compartment Confidence
golgi apparatus 5
cytosol 4
cytoskeleton 2
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RAB30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005795 Golgi stack TAS 9792283
GO:0005802 trans-Golgi network IDA 22188167
GO:0031985 Golgi cisterna IDA 22188167
genes like me logo Genes that share ontologies with RAB30: view

Pathways & Interactions for RAB30 Gene

genes like me logo Genes that share pathways with RAB30: view

Pathways by source for RAB30 Gene

Interacting Proteins for RAB30 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000260056%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000295822%0d%0a
Selected Interacting proteins: Q15771-RAB30_HUMAN ENSP00000260056 for RAB30 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for RAB30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007030 Golgi organization IMP 22188167
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with RAB30: view

No data available for SIGNOR curated interactions for RAB30 Gene

Drugs & Compounds for RAB30 Gene

No Compound Related Data Available

Transcripts for RAB30 Gene

Unigene Clusters for RAB30 Gene

RAB30, member RAS oncogene family:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAB30 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b · 10c · 10d · 10e ·
SP1: - - - - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - - - -
SP6: - - - - -
SP7: - - - - - - - -
SP8: - - -
SP9: - - -
SP10: -
SP11: - -
SP12: - - -

ExUns: 10f
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for RAB30 Gene

GeneLoc Exon Structure for
RAB30
ECgene alternative splicing isoforms for
RAB30

Expression for RAB30 Gene

mRNA expression in normal human tissues for RAB30 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RAB30 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (31.9), Brain (10.5), and Plasma (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB30 Gene



SOURCE GeneReport for Unigene cluster for RAB30 Gene Hs.40758

genes like me logo Genes that share expression patterns with RAB30: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for RAB30 Gene

Orthologs for RAB30 Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB30 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RAB30 35
  • 95.57 (n)
  • 100 (a)
RAB30 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAB30 35
  • 96.22 (n)
  • 100 (a)
RAB30 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rab30 35
  • 94.09 (n)
  • 100 (a)
Rab30 16
Rab30 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RAB30 35
  • 100 (n)
  • 100 (a)
RAB30 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rab30 35
  • 93.71 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia RAB30 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAB30 36
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAB30 35
  • 85.39 (n)
  • 98.52 (a)
RAB30 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAB30 36
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rab30 35
  • 80.95 (n)
  • 93.1 (a)
zebrafish
(Danio rerio)
Actinopterygii rab30 35
  • 76.29 (n)
  • 85.57 (a)
rab30 36
  • 86 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG2885 37
  • 36 (a)
CG9100 37
  • 73 (a)
Rab-RP3 37
  • 48 (a)
Rab30 35
  • 64.22 (n)
  • 69.11 (a)
Rab30 36
  • 60 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002092 35
  • 60.44 (n)
  • 65.66 (a)
worm
(Caenorhabditis elegans)
Secernentea rab-30 35
  • 60.5 (n)
  • 63.58 (a)
rab-30 36
  • 53 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13245 35
Species with no ortholog for RAB30:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB30 Gene

ENSEMBL:
Gene Tree for RAB30 (if available)
TreeFam:
Gene Tree for RAB30 (if available)

Paralogs for RAB30 Gene

genes like me logo Genes that share paralogs with RAB30: view

Variants for RAB30 Gene

Sequence variations from dbSNP and Humsavar for RAB30 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs948182 -- 83,035,189(-) ATTAG(A/G/T)TAGAC intron-variant, upstream-variant-2KB
rs948183 -- 83,011,258(+) TTTCC(C/T)ATGTA intron-variant
rs948184 -- 83,011,617(+) AACAA(A/G)AAGAT intron-variant
rs1011618 -- 82,980,008(-) CAAGT(G/T)TGTTG utr-variant-3-prime
rs1060296 -- 82,975,590(-) ATCTC(A/G)GTTTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RAB30 Gene

Variant ID Type Subtype PubMed ID
esv33531 CNV Loss 17666407
nsv515868 CNV Gain 19592680
nsv414 CNV Insertion 18451855

Variation tolerance for RAB30 Gene

Residual Variation Intolerance Score: 47.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.33; 7.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAB30 Gene

HapMap Linkage Disequilibrium report
RAB30

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB30 Gene

Disorders for RAB30 Gene

Relevant External Links for RAB30

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAB30

No disorders were found for RAB30 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB30 Gene

Publications for RAB30 Gene

  1. Molecular cloning of two novel rab genes from human melanocytes. (PMID: 8863739) Chen D. … Gahl W.A. (Gene 1996) 2 3 4 67
  2. Small GTP-binding proteins in human endothelial cells. (PMID: 9792283) de Leeuw H.P. … Voorberg J. (Br. J. Haematol. 1998) 2 3
  3. Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis. (PMID: 23326517) Holliday E.G. … Wang J.J. (PLoS ONE 2013) 3
  4. Toxoplasma gondii salvages sphingolipids from the host Golgi through the rerouting of selected Rab vesicles to the parasitophorous vacuole. (PMID: 23615442) Romano J.D. … Coppens I. (Mol. Biol. Cell 2013) 3
  5. The genetic architecture of economic and political preferences. (PMID: 22566634) Benjamin D.J. … Visscher P.M. (Proc. Natl. Acad. Sci. U.S.A. 2012) 3

Products for RAB30 Gene

Sources for RAB30 Gene

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