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Aliases for RAB2B Gene

Aliases for RAB2B Gene

  • RAB2B, Member RAS Oncogene Family 2 3 5

External Ids for RAB2B Gene

Previous GeneCards Identifiers for RAB2B Gene

  • GC14M015714
  • GC14M019917
  • GC14M020997
  • GC14M021927
  • GC14M002046

Summaries for RAB2B Gene

Entrez Gene Summary for RAB2B Gene

  • Members of the Rab protein family are nontransforming monomeric GTP-binding proteins of the Ras superfamily that contain 4 highly conserved regions involved in GTP binding and hydrolysis. Rab proteins are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking; see MIM 179508.[supplied by OMIM, Apr 2006]

GeneCards Summary for RAB2B Gene

RAB2B (RAB2B, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Metabolism of proteins. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB2A.

UniProtKB/Swiss-Prot for RAB2B Gene

  • Required for protein transport from the endoplasmic reticulum to the Golgi complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB2B Gene

Genomics for RAB2B Gene

Regulatory Elements for RAB2B Gene

Enhancers for RAB2B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F020827 1.1 Ensembl ENCODE 20.6 +649.1 649054 1.0 CTCF CBX3 PKNOX1 ZBTB40 RBAK ZNF585B ZNF26 TRIM24 ZBTB33 SETDB1 RAB2B ENSG00000258515 SUPT16H METTL3 ENSG00000258768 OSGEP RNASE1 TTC5 EDDM3A EDDM3B
GH14F021089 1.6 FANTOM5 Ensembl ENCODE 19.8 +376.9 376861 21.0 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC SUPT16H CHD8 ENSG00000258515 METTL3 TMEM55B ENSG00000258768 OSGEP RAB2B TTC5 RNASE4
GH14F020665 0.5 ENCODE 12.5 +811.4 811357 0.2 ELF3 DRAP1 CTCF ZNF792 SAP130 MLX ARID4B ZNF48 ZSCAN9 ZNF644 ENSG00000258768 RAB2B ENSG00000258515 OSGEP TTC5 SUPT16H GC14M020668 TRY-GTA5-4
GH14F021541 0.6 ENCODE 11.6 -64.9 -64937 0.5 ZNF680 ZFP64 TEAD4 ZNF140 REST YBX1 ZNF781 ZNF623 ZNF518A FOXA1 METTL3 SALL2 SUPT16H RAB2B CHD8 RBBP4P5
GH14F021068 0.7 FANTOM5 ENCODE 11.5 +405.9 405929 5.0 HDGF ZFP64 ARID4B SIN3A DMAP1 ZNF48 ETS1 GLIS2 ZNF143 FOS ARHGEF40 METTL3 SALL2 ENSG00000258515 SUPT16H TMEM253 ZNF219 TTC5 RAB2B CHD8
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RAB2B on UCSC Golden Path with GeneCards custom track

Promoters for RAB2B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000096762 -227 2801 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207

Genomic Location for RAB2B Gene

21,459,020 bp from pter
21,476,973 bp from pter
17,954 bases
Minus strand

Genomic View for RAB2B Gene

Genes around RAB2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB2B Gene

Proteins for RAB2B Gene

  • Protein details for RAB2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras-related protein Rab-2B
    Protein Accession:
    Secondary Accessions:
    • B2RD03
    • D3DS24
    • Q6NZ33

    Protein attributes for RAB2B Gene

    216 amino acids
    Molecular mass:
    24214 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RAB2B Gene

    Alternative splice isoforms for RAB2B Gene


neXtProt entry for RAB2B Gene

Post-translational modifications for RAB2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB2B Gene

No data available for DME Specific Peptides for RAB2B Gene

Domains & Families for RAB2B Gene

Gene Families for RAB2B Gene

Protein Domains for RAB2B Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Rab family.
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB2B: view

Function for RAB2B Gene

Molecular function for RAB2B Gene

UniProtKB/Swiss-Prot Function:
Required for protein transport from the endoplasmic reticulum to the Golgi complex.

Gene Ontology (GO) - Molecular Function for RAB2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RAB2B: view

Phenotypes for RAB2B Gene

genes like me logo Genes that share phenotypes with RAB2B: view

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RAB2B

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB2B Gene

Localization for RAB2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB2B Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Endoplasmic reticulum membrane. Golgi apparatus membrane.

Subcellular locations from

Jensen Localization Image for RAB2B Gene COMPARTMENTS Subcellular localization image for RAB2B gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
golgi apparatus 4
plasma membrane 4
cytosol 3
cytoskeleton 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RAB2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005622 intracellular IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with RAB2B: view

Pathways & Interactions for RAB2B Gene

genes like me logo Genes that share pathways with RAB2B: view

Pathways by source for RAB2B Gene

1 Qiagen pathway for RAB2B Gene

Gene Ontology (GO) - Biological Process for RAB2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport IEA --
GO:0045921 positive regulation of exocytosis IMP 19966785
genes like me logo Genes that share ontologies with RAB2B: view

No data available for SIGNOR curated interactions for RAB2B Gene

Transcripts for RAB2B Gene

Unigene Clusters for RAB2B Gene

RAB2B, member RAS oncogene family:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RAB2B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB2B Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1: - - -
SP2: - - - -
SP3: - -
SP4: - -
SP5: -

Relevant External Links for RAB2B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RAB2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RAB2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RAB2B Gene

This gene is overexpressed in Brain (23.5) and Fetal Brain (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RAB2B Gene

Protein tissue co-expression partners for RAB2B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RAB2B Gene:


SOURCE GeneReport for Unigene cluster for RAB2B Gene:


mRNA Expression by UniProt/SwissProt for RAB2B Gene:

Tissue specificity: Expressed in kidney, prostate, lung, liver, thymus, colon, pancreas, and skeletal muscle, and low levels in placenta. Not detected in heart, brain, spleen, testis, ovary, small intestine and leukocyte.
genes like me logo Genes that share expression patterns with RAB2B: view

Primer Products

No data available for mRNA differential expression in normal tissues for RAB2B Gene

Orthologs for RAB2B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RAB2B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RAB2B 34 35
  • 99.38 (n)
(Bos Taurus)
Mammalia RAB2B 34 35
  • 94.44 (n)
(Canis familiaris)
Mammalia RAB2B 34 35
  • 93.67 (n)
(Monodelphis domestica)
Mammalia RAB2B 35
  • 93 (a)
(Rattus norvegicus)
Mammalia Rab2b 34
  • 91.47 (n)
(Mus musculus)
Mammalia Rab2b 34 16 35
  • 91.2 (n)
(Ornithorhynchus anatinus)
Mammalia RAB2B 35
  • 74 (a)
(Gallus gallus)
Aves -- 35
  • 49 (a)
(Anolis carolinensis)
Reptilia RAB2B 35
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rab2b 34
  • 74.11 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.2749 34
(Danio rerio)
Actinopterygii rab11al 35
  • 46 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rab2 35
  • 83 (a)
(Caenorhabditis elegans)
Secernentea unc-108 35
  • 86 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPT31 35
  • 41 (a)
YPT32 35
  • 39 (a)
(Oryza sativa)
Liliopsida Os04g0470100 34
  • 68.28 (n)
(Hordeum vulgare)
Liliopsida Hv.5672 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 29 (a)
Species where no ortholog for RAB2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB2B Gene

Gene Tree for RAB2B (if available)
Gene Tree for RAB2B (if available)

Paralogs for RAB2B Gene

genes like me logo Genes that share paralogs with RAB2B: view

Variants for RAB2B Gene

Sequence variations from dbSNP and Humsavar for RAB2B Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10135371 -- 21,471,899(+) tcaaa(C/G)tcctg intron-variant
rs10143000 -- 21,462,437(+) AAATC(A/G)TATCA intron-variant
rs10145520 -- 21,462,773(+) GCGCA(G/T)GTTGC intron-variant
rs10146118 -- 21,470,625(+) TTACA(C/G)TTTTA intron-variant
rs10149219 -- 21,464,209(+) agcct(A/G)gccaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB2B Gene

Variant ID Type Subtype PubMed ID
esv2422459 CNV duplication 17116639
esv3633716 CNV gain 21293372

Variation tolerance for RAB2B Gene

Residual Variation Intolerance Score: 25.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.82; 17.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAB2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB2B Gene

Disorders for RAB2B Gene

Relevant External Links for RAB2B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RAB2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB2B Gene

Publications for RAB2B Gene

  1. Molecular cloning and characterization of a novel human Rab (Rab2B) gene. (PMID: 12376746) Ni X. … Mao Y. (J. Hum. Genet. 2002) 2 3 4 22 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3 64
  5. Small GTPase Rab2B and Its Specific Binding Protein Golgi-associated Rab2B Interactor-like 4 (GARI-L4) Regulate Golgi Morphology. (PMID: 26209634) Aizawa M. … Fukuda M. (J. Biol. Chem. 2015) 3 64

Products for RAB2B Gene

Sources for RAB2B Gene

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