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Aliases for RAB2B Gene

Aliases for RAB2B Gene

  • RAB2B, Member RAS Oncogene Family 2 3 5

External Ids for RAB2B Gene

Previous GeneCards Identifiers for RAB2B Gene

  • GC14M015714
  • GC14M019917
  • GC14M020997
  • GC14M021927
  • GC14M002046

Summaries for RAB2B Gene

Entrez Gene Summary for RAB2B Gene

  • Members of the Rab protein family are nontransforming monomeric GTP-binding proteins of the Ras superfamily that contain 4 highly conserved regions involved in GTP binding and hydrolysis. Rab proteins are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking; see MIM 179508.[supplied by OMIM, Apr 2006]

GeneCards Summary for RAB2B Gene

RAB2B (RAB2B, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are RAB geranylgeranylation and Metabolism of proteins. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB2A.

UniProtKB/Swiss-Prot for RAB2B Gene

  • Required for protein transport from the endoplasmic reticulum to the Golgi complex.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB2B Gene

Genomics for RAB2B Gene

Regulatory Elements for RAB2B Gene

Enhancers for RAB2B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G020679 1.9 FANTOM5 ENCODE dbSUPER 19.5 +792.4 792441 9.8 MLX CREB3L1 ZFP64 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 CHD8 SUPT16H ENSG00000258515 METTL3 TTC5 ENSG00000258768 PARP2 TMEM55B RNASE4 RAB2B
GH14G021092 2 FANTOM5 Ensembl ENCODE dbSUPER 10.3 +375.5 375547 18.3 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC SUPT16H ENSG00000258768 ENSG00000258515 CHD8 ARHGEF40 OSGEP TTC5 TMEM55B RAB2B PARP2
GH14G020798 1.6 Ensembl ENCODE dbSUPER 10.3 +676.1 676067 5.6 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B METTL3 SUPT16H CHD8 ENSG00000258515 TMEM55B RAB2B OR11H7 RNASE1 LOC105370397
GH14G021263 1.6 Ensembl ENCODE dbSUPER 10.3 +209.9 209919 7.6 HDGF PKNOX1 FOXA2 MLX CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 SUPT16H METTL3 CHD8 ENSG00000258515 TMEM55B RAB2B APEX1 TRAV8-5 TOX4 HNRNPC
GH14G020612 1.4 Ensembl ENCODE 10.9 +863.3 863267 3.3 HDGF PKNOX1 FOXA2 CREB3L1 ARNT WRNIP1 ARID4B SIN3A FEZF1 DMAP1 METTL3 SUPT16H ENSG00000258515 CHD8 APEX1 ENSG00000258768 OSGEP PARP2 ENSG00000260830 TTC5
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RAB2B on UCSC Golden Path with GeneCards custom track

Promoters for RAB2B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000066486 -127 2201 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207

Genomic Location for RAB2B Gene

Chromosome:
14
Start:
21,459,020 bp from pter
End:
21,476,973 bp from pter
Size:
17,954 bases
Orientation:
Minus strand

Genomic View for RAB2B Gene

Genes around RAB2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB2B Gene

Proteins for RAB2B Gene

  • Protein details for RAB2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUD1-RAB2B_HUMAN
    Recommended name:
    Ras-related protein Rab-2B
    Protein Accession:
    Q8WUD1
    Secondary Accessions:
    • B2RD03
    • D3DS24
    • Q6NZ33

    Protein attributes for RAB2B Gene

    Size:
    216 amino acids
    Molecular mass:
    24214 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RAB2B Gene

    Alternative splice isoforms for RAB2B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAB2B Gene

Post-translational modifications for RAB2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB2B Gene

No data available for DME Specific Peptides for RAB2B Gene

Domains & Families for RAB2B Gene

Gene Families for RAB2B Gene

Protein Domains for RAB2B Gene

Graphical View of Domain Structure for InterPro Entry

Q8WUD1

UniProtKB/Swiss-Prot:

RAB2B_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB2B: view

Function for RAB2B Gene

Molecular function for RAB2B Gene

UniProtKB/Swiss-Prot Function:
Required for protein transport from the endoplasmic reticulum to the Golgi complex.

Gene Ontology (GO) - Molecular Function for RAB2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003924 GTPase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RAB2B: view

Phenotypes for RAB2B Gene

genes like me logo Genes that share phenotypes with RAB2B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RAB2B

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB2B Gene

Localization for RAB2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB2B Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Endoplasmic reticulum membrane. Golgi apparatus membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB2B gene
Compartment Confidence
extracellular 5
plasma membrane 4
endoplasmic reticulum 4
golgi apparatus 4
cytosol 3
cytoskeleton 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RAB2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005622 intracellular IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with RAB2B: view

Pathways & Interactions for RAB2B Gene

genes like me logo Genes that share pathways with RAB2B: view

Pathways by source for RAB2B Gene

Gene Ontology (GO) - Biological Process for RAB2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport IEA --
GO:0045921 positive regulation of exocytosis IMP 19966785
genes like me logo Genes that share ontologies with RAB2B: view

No data available for SIGNOR curated interactions for RAB2B Gene

Transcripts for RAB2B Gene

Unigene Clusters for RAB2B Gene

RAB2B, member RAS oncogene family:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RAB2B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB2B Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1: - - -
SP2: - - - -
SP3: - -
SP4: - -
SP5: -

Relevant External Links for RAB2B Gene

GeneLoc Exon Structure for
RAB2B
ECgene alternative splicing isoforms for
RAB2B

Expression for RAB2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAB2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RAB2B Gene

This gene is overexpressed in Brain (23.5) and Fetal Brain (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RAB2B Gene



Protein tissue co-expression partners for RAB2B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RAB2B Gene:

RAB2B

SOURCE GeneReport for Unigene cluster for RAB2B Gene:

Hs.22399

mRNA Expression by UniProt/SwissProt for RAB2B Gene:

Q8WUD1-RAB2B_HUMAN
Tissue specificity: Expressed in kidney, prostate, lung, liver, thymus, colon, pancreas, and skeletal muscle, and low levels in placenta. Not detected in heart, brain, spleen, testis, ovary, small intestine and leukocyte.

Evidence on tissue expression from TISSUES for RAB2B Gene

  • Nervous system(4.6)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with RAB2B: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAB2B Gene

Orthologs for RAB2B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RAB2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB2B 34 35
  • 99.38 (n)
cow
(Bos Taurus)
Mammalia RAB2B 34 35
  • 94.44 (n)
dog
(Canis familiaris)
Mammalia RAB2B 34 35
  • 93.67 (n)
oppossum
(Monodelphis domestica)
Mammalia RAB2B 35
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rab2b 34
  • 91.47 (n)
mouse
(Mus musculus)
Mammalia Rab2b 34 16 35
  • 91.2 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RAB2B 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 49 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia RAB2B 35
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rab2b 34
  • 74.11 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.2749 34
zebrafish
(Danio rerio)
Actinopterygii rab11al 35
  • 46 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Rab2 35
  • 83 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-108 35
  • 86 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPT31 35
  • 41 (a)
ManyToMany
YPT32 35
  • 39 (a)
ManyToMany
rice
(Oryza sativa)
Liliopsida Os04g0470100 34
  • 68.28 (n)
barley
(Hordeum vulgare)
Liliopsida Hv.5672 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 29 (a)
ManyToMany
Species where no ortholog for RAB2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB2B Gene

ENSEMBL:
Gene Tree for RAB2B (if available)
TreeFam:
Gene Tree for RAB2B (if available)

Paralogs for RAB2B Gene

genes like me logo Genes that share paralogs with RAB2B: view

Variants for RAB2B Gene

Sequence variations from dbSNP and Humsavar for RAB2B Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000014645 -- 21,467,467(+) TACTA(A/T)GCGGT intron-variant
rs1000061699 -- 21,462,571(+) GCGGT(A/G)GCTCA intron-variant
rs1000075727 -- 21,473,419(+) ATGCA(C/T)ATGAA intron-variant
rs1000421889 -- 21,478,885(+) TGCAG(C/T)CTCCA intron-variant, upstream-variant-2KB
rs1000616826 -- 21,469,005(+) ATTAG(C/T)GGATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB2B Gene

Variant ID Type Subtype PubMed ID
esv2422459 CNV duplication 17116639
esv3633716 CNV gain 21293372

Variation tolerance for RAB2B Gene

Residual Variation Intolerance Score: 25.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.82; 17.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAB2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAB2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB2B Gene

Disorders for RAB2B Gene

Relevant External Links for RAB2B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAB2B

No disorders were found for RAB2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB2B Gene

Publications for RAB2B Gene

  1. Molecular cloning and characterization of a novel human Rab (Rab2B) gene. (PMID: 12376746) Ni X. … Mao Y. (J. Hum. Genet. 2002) 2 3 4 22 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3 64
  5. Small GTPase Rab2B and Its Specific Binding Protein Golgi-associated Rab2B Interactor-like 4 (GARI-L4) Regulate Golgi Morphology. (PMID: 26209634) Aizawa M. … Fukuda M. (J. Biol. Chem. 2015) 3 64

Products for RAB2B Gene

Sources for RAB2B Gene

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