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RAB2A Gene

protein-coding   GIFtS: 54

GC08P061593
RAB2A, member RAS oncogene family
(Previous names: RAB2, member RAS oncogene family )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: RAB2)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
RAB2 2, 3, 5
Descriptions
RAB2, member RAS oncogene family 1, 2
RAB2A, member RAS oncogene family 2
small GTP binding protein RAB2A 2
External Ids
HGNC: 97631
Entrez Gene: 58622
UniProtKB: P610193
Ensembl: ENSG000001043887
Search outside databases for aliases for RAB2A gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for RAB2A:
Members of the Rab protein family are nontransforming monomeric GTP-binding proteins of the Ras
superfamily that contain 4 highly conserved regions involved in GTP binding and hydrolysis. Rabs
are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking. The
mammalian RAB proteins show striking similarities to the S. cerevisiae YPT1 and SEC4 proteins,
Ras-related GTP-binding proteins involved in the regulation of secretion.[supplied by OMIM]

UniProtKB/Swiss-Prot: RAB2A_HUMAN, P61019
Function: Required for protein transport from the endoplasmic reticulum to the Golgi complex

Gene Wiki entry for RAB2A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q12.1   Ensembl cytogenetic band:  8q12.1   HGNC cytogenetic band: 8q12.1

RAB2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P061593:     (about GC identifiers)

Start:
61,592,113 bp from pter
End:
61,696,183 bp from pter
Size:
104,071 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000008.9  NT_008183.18  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: RAB2A_HUMAN, P61019 (See protein sequence)
Recommended Name: Ras-related protein Rab-2A  
Size: 212 amino acids; 23546 Da
Subunit: Interacts with PRKCI
Subcellular location: Endoplasmic reticulum-Golgi intermediate compartment membrane; Lipid-anchor.
Melanosome. Endoplasmic reticulum membrane; Lipid-anchor (Potential). Golgi apparatus membrane;
Lipid-anchor (Potential). Note=Identified by mass spectrometry in melanosome fractions from stage
I to stage IV
PDB structures from and Proteopedia :
1Z0A (3D)    
Secondary accessions: P08886

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_002856.1  

    ENSEMBL proteins: 
    ENSP00000379924 ENSP00000379925 ENSP00000262646 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Sigma-Aldrich AQUA Peptides for RAB2A  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse Abcam for Recombinant Proteins
    Human Recombinant Proteins from Abnova (RAB2A)
                  OriGene Purified Recombinant Human Protein: RAB2A 

    5/7 Gene Ontology (GO) cellular component terms (links to tree view) (see all 7 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139 Golgi membrane IEA--
    GO:0005783 endoplasmic reticulum IEA--
    GO:0005789 endoplasmic reticulum membrane IEA--
    GO:0005794 Golgi apparatus IEA--
    GO:0016020 membrane IEA--
    About this table

    Antibodies for RAB2A: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
    Monoclonal and Polyclonal Antibodies from Abnova (RAB2A)
    Novus Biologicals Antibodies for RAB2A

    Assays for RAB2A: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    4 InterPro domains/families:
     IPR001806 Ras_GTPase
     IPR005225 Small_GTP_bd
     IPR003579 GTPase_Rab
     IPR013753 Ras


       GeneDecks  RAB2A for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P61019

    ProtoNet protein and cluster: P61019

    4 Blocks protein families:
    IPB001806 Transforming protein P21 RAS signature
    IPB002041 GTP-binding nuclear protein Ran
    IPB003577 Ras small GTPase
    IPB003578 Ras small GTPase


    UniProtKB/Swiss-Prot: RAB2A_HUMAN, P61019
    Similarity: Belongs to the small GTPase superfamily. Rab family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (RAB2A)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (RAB2A)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002865

                  Applied Biosystems Silencer® siRNAs for RAB2A

                  Sigma-Aldrich siRNA for RAB2A  
                         Sigma-Aldrich shRNA for RAB2A  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for RAB2A
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_002865
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_002865
                                     untagged cDNA clone in CMV expression vector: NM_002865 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_002865

    UniProtKB/Swiss-Prot: RAB2A_HUMAN, P61019
    Function: Required for protein transport from the endoplasmic reticulum to the Golgi complex

    3 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0003924 GTPase activity TAS2501306
    GO:0005525 GTP binding IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


     Gene Network CentralTM Interacting Genes and Proteins Network for  RAB2A 


    5/11 Interacting proteins for RAB2A (P610192 ENSP000002626463) via UniProtKB, MINT, and/or STRING (see all 11 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FAM71CQ8NEG02MINT-68362
    GOLGA2Q083792MINT-68436
    GAPDHL6ENSP000002292393STRING (score=.979)
    GORASP2ENSP000002341603STRING (score=.97)
    BLZF1ENSP000003275413STRING (score=.967)
    About this table

    4 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006888 ER to Golgi vesicle-mediated transport TAS8910601
    GO:0007264 small GTPase mediated signal transduction IEA--
    GO:0015031 protein transport IEA--
    GO:0016192 vesicle-mediated transport IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for RAB2A
    2 Novoseek chemical compound relationships for RAB2A gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    vtcs 94.11 7 16452474 (4), 16473604 (2), 11208158 (1)
    glyceraldehyde 3-phosphate 65.88 8 19106097 (2), 16473604 (2), 16452474 (2)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (RAB2A)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (RAB2A)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002865

                  Sigma-Aldrich siRNA for RAB2A  
                         Sigma-Aldrich shRNA for RAB2A  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_002865  

    REFSEQ mRNAs for RAB2A gene: 

    NM_002865.1   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_002865  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_002865
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_002865
                                     untagged cDNA clone in CMV expression vector: NM_002865 

    Additional cDNA sequence: 

    AF070629.1 AF498930.1 AK297576.1 AK312344.1 AL137321.1 AY034106.1 BC008929.2 BT019695.1 
    CR605346.1 CR624395.1 M28213.1 S48723.1 X12953.1 

    24/32 DOTS entries (see all 32 ):

    DT.121465159  DT.92447379  DT.75160557  DT.100828439  DT.121465184  DT.100828440  DT.91897065  DT.100037921 
    DT.100828441  DT.91743610  DT.100778514  DT.121465125  DT.450288  DT.95344436  DT.100693540  DT.100828437 
    DT.102833609  DT.121465115  DT.121465150  DT.121465170  DT.121465174  DT.121465182  DT.121465209  DT.121465210 

    24/508 AceView cDNA sequences (see all 508 ):

    CB241252 CB128846 BM793987 CA841655 AI800540 CB150602 BM559855 H96991 
    CB150242 BM835858 X12953 CA848385 AI312834 AU118172 BC008929 BF038471 
    BF437914 CR605346 BF968076 BM817586 AI791989 BU739368 BP378891 BU687490 

    highest scoring ESTs for RAB2A:

    M28213 AA064936 AA096405 AA113275 AA128137 AA149772 AA229908 AA252343 AA331035 AA400515 

    Unigene Cluster for RAB2A:

    RAB2A, member RAS oncogene family
    Hs.369017  [show with all ESTs]
    Unigene Representative Sequence: AL137321


    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RAB2A

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9
    SP1:                    -           -                 -           -               
    SP2:                    -                             -                           
    SP3:                    -           -                 -                           
    SP4:                                                              -               
    SP5:                                                                              

    About this scheme

    ECgene alternative splicing isoforms for RAB2A

    3 Ensembl transcripts including schematic representations:
    ENST00000396696  ENST00000396697  ENST00000262646  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    RAB2A expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for RAB2A

    1 / 2 / 3

    7 probe-sets matching RAB2A gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    623_s_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 M28213 1.00 1.00 1.00 1

    208734_x_at2, 3 U133-A 1 1.00 1.00 -- -- M28213 1.00 1.00 1.00 1

    208731_at2, 3 U133-A 1 1.00 1.00 -- -- AU158062 0.60 1.00 0.82 1

    208730_x_at2, 3 U133-A 9 1.00 0.64 -- -- AA535244 0.20 1.00 0.72 1

    208734_x_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    208731_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    208730_x_at2 U133Plus2 9 1.00 0.64 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: CAGGACAGTT

    SOURCE GeneReport for Unigene cluster: Hs.369017
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for RAB2A gene from 5/20 species (see all 20 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    RAB2A1   -- RAB2A, member RAS oncogene family 96.23(n)
    100(a)
    404009  NM_001003318.1  NP_001003318.1 
    chimpanzee
    (Pan troglodytes)
    RAB2A1   -- RAB2A, member RAS oncogene family 99.84(n)
    99.53(a)
    464197  XM_001158465.1  XP_001158465.1 
    cow
    (Bos taurus)
    RAB2A1   -- RAB2A, member RAS oncogene family 95.59(n)
    99.47(a)
    508373  NM_001075354.1  NP_001068822.1 
    rat
    (Rattus norvegicus)
    Rab2a1   -- RAB2A, member RAS oncogene family 92.14(n)
    98.58(a)
    65158  NM_031718.1  NP_113906.1 
    mouse
    (Mus musculus)
    Rab2a1, 5 45
    RAB2A, member RAS oncogene family1, 5 91.98(n)1
    98.58(a)1
    590211  NM_021518.31  NP_067493.11 
     AB2325855  AK0428625  (see all 31)
    About this table        Species with no ortholog for RAB2A

    ENSEMBL Gene Tree for RAB2A
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for RAB2A gene
    RAB142  RAB4A2  RAB4B2  RAB2B2  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/684 NCBI SNPs in RAB2A are shown (see all 684 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 165)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 8 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs28759671,2
    A,C,F,H61590834(-) ACTTTT/GCTTTT 1 -- ng516Minor allele frequency- G:0.35EU WA NA EA 602
    rs70140331,2
    A,C,F,H61590995(+) AAAAAT/CGTCAA 1 -- ng518Minor allele frequency- C:0.05EU EA WA 836
    rs23265621,2
    A,C,F,H61590754(-) AATAGA/GGTGTC 1 -- ng514Minor allele frequency- G:0.36EU EA WA 412
    rs5952551,2
    A,C,F,H,O61685464(-) ATGCAA/GGTATT 1 -- int119Minor allele frequency- G:0.41EA NA EU WA 1630
    rs29461541,2
    A,C,F,H,O61651413(-) GAACAC/TACCTC 1 -- int12Minor allele frequency- T:0.29EU WA 238
    rs22726201,2
    A,C,F,H,O61614600(+) TCAGCG/ATCATA 1 -- int15Minor allele frequency- A:0.35NA EU WA 374
    rs6712751,2
    A,C,F,H,O61688334(-) AAAGTC/TAAGGA 1 -- int17Minor allele frequency- T:0.43NA EU EA WA 560
    rs6845731,2
    A,C,F,H,O61688954(-) TACAGT/GTATCC 1 -- int111Minor allele frequency- G:0.25EU EA WA NA 972
    rs22726211,2
    A,C,F,H,O61614856(+) AATGCC/GTTTTT 1 -- int14Minor allele frequency- G:0.40EA WA 1746
    rs6258501,2
    A,C,F,H,O61689507(-) TTCTGT/CAGGTA 1 -- int17Minor allele frequency- C:0.43EU EA WA NA 558
    About this table

    HapMap Linkage Disequilibrium images for RAB2A (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 179509

    1 Novoseek disease relationship for RAB2A gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    sezary syndrome 78.59 2 8096558 (1), 8511040 (1)
    About this table

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/29 PubMed articles for RAB2A gene (see all 29 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 5862 HGNC: 9763 AceView: RAB2 Ensembl:ENSG00000104388 euGenes: HUgn5862
    ECgene: RAB2A H-InvDB: RAB2A
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for RAB2A:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Predesigned and custom siRNAs for RAB2A Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Proteins for RAB2A
     Lentivirus-delivered shRNAs for RAB2A Browse small molecules at Sigma-Aldrich
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