Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RAB2A Gene

protein-coding   GIFtS: 60
GCID: GC08P061429

RAB2A, member RAS oncogene family

(Previous names: RAB2, member RAS oncogene family )
(Previous symbol: RAB2)
 Explore 8 diseases affiliated with
RAB2A via our new
 Human Malady Compendium 
Biological research products
for RAB2A
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
RAB2A, Member RAS Oncogene Family1 2
RAB21 2 3 5
RAB2, Member RAS Oncogene Family1 2
LHX2
Ras-Related Protein Rab-2A2
Small GTP Binding Protein RAB2A2

External Ids:    HGNC: 97631   Entrez Gene: 58622   Ensembl: ENSG000001043887   OMIM: 1795095   UniProtKB: P610193   

Export aliases for RAB2A gene to outside databases

Previous GC identifers: GC08P061593 GC08P056918


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RAB2A:
The protein encoded by this gene belongs to the Rab family, members of which are small molecular weight guanosine
triphosphatases (GTPases) that contain highly conserved domains involved in GTP binding and hydrolysis. The Rabs are
membrane-bound proteins, involved in vesicular fusion and trafficking. This protein is a resident of pre-Golgi
intermediates, and is required for protein transport from the endoplasmic reticulum (ER) to the Golgi complex.
Alternatively spliced transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Oct 2011)

UniProtKB/Swiss-Prot: RAB2A_HUMAN, P61019
Function: Required for protein transport from the endoplasmic reticulum to the Golgi complex

Gene Wiki entry for RAB2A


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_008183.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RAB2A gene promoter:
         Nkx3-1   Tal-1   GATA-3   AP-1   ATF-2   E47   Egr-2   c-Jun   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRAB2A promoter sequence
   Search SABiosciences Chromatin IP Primers for RAB2A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB2A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q12.1   Ensembl cytogenetic band:  8q12.1   HGNC cytogenetic band: 8q12.1

RAB2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAB2A gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P061429:  view genomic region     (about GC identifiers)

Start:
61,429,416 bp from pter      End:
61,536,186 bp from pter
Size:
106,771 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RAB2A_HUMAN, P61019 (See protein sequence)
Recommended Name: Ras-related protein Rab-2A  
Size: 212 amino acids; 23546 Da
Subunit: Interacts with PRKCI
Subcellular location: Endoplasmic reticulum-Golgi intermediate compartment membrane; Lipid-anchor. Melanosome.
Endoplasmic reticulum membrane; Lipid-anchor (Potential). Golgi apparatus membrane; Lipid-anchor (Potential).
Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV
1 PDB 3D structure from and Proteopedia for RAB2A:
1Z0A (3D)    
Secondary accessions: B2R5W8 B4DMQ5 P08886
Alternative splicing: 2 isoforms:  P61019-1   P61019-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RAB2A: NX_P61019

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P61019

  • RAB2A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001229573.1  NP_002856.1  

    ENSEMBL proteins: 
     ENSP00000262646   ENSP00000431846   ENSP00000431589   ENSP00000432855   ENSP00000432735  
     ENSP00000433875   ENSP00000398054  
    Reactome Protein details: P61019
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: RAB2A
    OriGene Protein Over-expression Lysate: RAB2A
    OriGene Custom Protein Services for RAB2A 
    GenScript Custom Purified and Recombinant Proteins Services for RAB2A
    Novus Biologicals RAB2A Proteins
    Novus Biologicals RAB2A Lysate
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for RAB2A
    Uscn Proteins for RAB2A

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005624membrane fraction ----
    GO:0005625soluble fraction ----
    GO:0005626insoluble fraction ----
    GO:0005789endoplasmic reticulum membrane IEA--


    RAB2A for ontologies           About GeneDecksing



    RAB2A Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies (see all 2): RAB2A
    OriGene Custom Antibody Services for RAB2A 
    GenScript Custom Superior Antibodies Services for RAB2A
    Novus Biologicals RAB2A Antibodies
    Abcam antibodies for RAB2A 
    Uscn Antibodies for RAB2A
    ThermoFisher Antibody for RAB2A

    Assay Products for RAB2A: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RAB2A
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for RAB2A


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    RAB2A for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR003579 Small_GTPase_Rab_type

    Graphical View of Domain Structure for InterPro Entry P61019

    ProtoNet protein and cluster: P61019

    4 Blocks protein families:
    IPB001806 Transforming protein P21 RAS signature
    IPB002041 GTP-binding nuclear protein Ran
    IPB003577 Ras small GTPase
    IPB003578 Ras small GTPase


    UniProtKB/Swiss-Prot: RAB2A_HUMAN, P61019
    Similarity: Belongs to the small GTPase superfamily. Rab family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: RAB2A_HUMAN, P61019
    Function: Required for protein transport from the endoplasmic reticulum to the Golgi complex

    miRNA
    Products:
        
    miRTarBase miRNAs that target RAB2A:
    hsa-mir-192 (MIRT004140)

    OriGene 3'-UTR Clone: RAB2A
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAB2A
    8/113 QIAGEN miScript miRNA Assays for microRNAs that regulate RAB2A (see all 113):
    hsa-miR-323-3p hsa-miR-548j hsa-miR-100* hsa-miR-300 hsa-miR-4272 hsa-miR-3138 hsa-miR-578 hsa-miR-4325
    SwitchGear 3'UTR luciferase reporter plasmidRAB2A 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAB2A (see all 4)
    OriGene shRNA RFP: RAB2A
    OriGene siRNA: RAB2A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAB2A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RAB2A

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAB2A (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAB2A
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: RAB2A (NM_002865)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAB2A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB2A 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RAB2A
    Search LifeMap BioReagents cell lines for RAB2A

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB2A

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IDA16034420
    GO:0005525GTP binding IDA16034420
    GO:0019003GDP binding IDA16034420


    RAB2A for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for RAB2A:
     Decreased Tat-dependent transc  Decreased p24 protein expressi  Increased resistance to MDM2 i 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1M Phase
    M Phase1.00
    Mitotic M-M/G1 phases0.88
    2Cell Cycle
    Cell Cycle1.00
    Cell Cycle, Mitotic0.84
    3Clearance of Nuclear Envelope Membranes from Chromatin
    Mitotic Prophase0.26
    Golgi Cisternae Pericentriolar Stack Reorganization0.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/6        Reactome Pathways for RAB2A (see all 6)
        Golgi Cisternae Pericentriolar Stack Reorganization
    Mitotic Prophase
    Cell Cycle
    M Phase
    Mitotic M-M/G1 phases



    RAB2A for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAB2A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/22 Interacting proteins for RAB2A (P610192, 3 ENSP000002626464) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FAM71CQ8NEG02, 3, ENSP000003152474MINT-68362 I2D: score=4 STRING: ENSP00000315247
    MAPKAPK3Q166442, 3, ENSP000003506394MINT-8262764 I2D: score=2 STRING: ENSP00000350639
    RGS2P412202, 3MINT-8268900 I2D: score=2 
    GOLGA2Q083792, 3, ENSP000004160974MINT-68436 I2D: score=6 STRING: ENSP00000416097
    MAPK6Q166592, 3, ENSP000002618454MINT-8261802 I2D: score=2 STRING: ENSP00000261845
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process TAS2501306
    GO:0006888ER to Golgi vesicle-mediated transport TAS8910601
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0015031protein transport IEA--


    RAB2A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RAB2A for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RAB2A
    2 Novoseek chemical compound relationships for RAB2A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vtcs 94.3 7 16452474 (4), 16473604 (2), 11208158 (1)
    glyceraldehyde 3-phosphate 66.1 8 19106097 (2), 16473604 (2), 16452474 (2)

    Search CenterWatch for drugs/clinical trials and news about RAB2A 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RAB2A gene (2 alternative transcripts): 
    NM_001242644.1  NM_002865.2  

    Unigene Cluster for RAB2A:

    RAB2A, member RAS oncogene family
    Hs.369017  [show with all ESTs]
    Unigene Representative Sequence: NM_002865
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262646(uc003xud.2 uc011lef.2) ENST00000531289 ENST00000481569
    ENST00000529579 ENST00000466595 ENST00000429861 ENST00000531098 ENST00000534260
    ENST00000525529 ENST00000530071 ENST00000452437 ENST00000396696

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: RAB2A
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAB2A
    8/113 QIAGEN miScript miRNA Assays for microRNAs that regulate RAB2A (see all 113):
    hsa-miR-323-3p hsa-miR-548j hsa-miR-100* hsa-miR-300 hsa-miR-4272 hsa-miR-3138 hsa-miR-578 hsa-miR-4325
    SwitchGear 3'UTR luciferase reporter plasmidRAB2A 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAB2A (see all 4)
    OriGene shRNA RFP: RAB2A
    OriGene siRNA: RAB2A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAB2A
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAB2A (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAB2A
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: RAB2A (NM_002865)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAB2A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB2A 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAB2A
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RAB2A
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAB2A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAB2A

    Additional cDNA sequence: 

    AF070629.1 AF498930.1 AK297576.1 AK312344.1 AL137321.1 AY034106.1 BC008929.2 BT019695.1 
    M28213.1 S48723.1 X12953.1 

    24/32 DOTS entries (see all 32):

    DT.121465159  DT.92447379  DT.75160557  DT.100828439  DT.121465184  DT.100828440  DT.91897065  DT.100037921 
    DT.100828441  DT.91743610  DT.100778514  DT.121465125  DT.450288  DT.95344436  DT.100693540  DT.100828437 
    DT.121465115  DT.121465150  DT.121465170  DT.121465174  DT.121465182  DT.121465209  DT.121465210  DT.40116636 

    24/508 AceView cDNA sequences (see all 508):

    AU139525 AA670481 X12953 BE549863 BM835858 CB128846 BG152906 BM714729 
    CB155677 CD107897 NM_002865 BQ689948 BQ025681 BU177097 BQ213353 T28639 
    CA848385 BM505056 BU687490 AI337858 H97101 AI143512 CD514368 BP378891 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RAB2A    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9
    SP1:                    -           -                 -           -               
    SP2:                    -                             -                           
    SP3:                    -           -                 -                           
    SP4:                                                              -               
    SP5:                                                                              


    ECgene alternative splicing isoforms for RAB2A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RAB2A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAGGACAGTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See RAB2A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RAB2A

    SOURCE GeneReport for Unigene cluster: Hs.369017
        SABiosciences Custom PCR Arrays for RAB2A
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAB2A
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RAB2A
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAB2A
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAB2A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB2A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RAB2A gene from 8/34 species (see all 34)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves RAB2A1 RAB2A, member RAS oncogene family 87.42(n)
    99.53(a)
      396153  NM_205228.1  NP_990559.1 
    lizard
    (Anolis carolinensis)
    Reptilia RAB2A6
    RAB2B6
    --
    94(a)
    67(a)
    1 ↔ 1
    possible ortholog
    4(28461559-28493287)
    GL343466.1(460479-470285)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia CF240859.12   -- 83.08(n)    CF240859.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.209142 Danio rerio mRNA similar to RAB2, member RAS oncogene more 81.58(n)    BC044459.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rab21 Rab-protein 2 72.01(n)
    90.09(a)
      35577  NM_057742.3  NP_477090.1 
    worm
    (Caenorhabditis elegans)
    Secernentea unc-1081 Protein UNC-108 72.96(n)
    88.68(a)
      171956  NM_058832.3  NP_491233.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons RABB1C1 RAB GTPase homolog B1C 71.27(n)
    79.05(a)
      827428  NM_117821.3  NP_193450.1 
    rice
    (Oryza sativa)
    Liliopsida Os.84832 Oryza sativa (japonica cultivar-group) cDNA clone0 more 74.99(n)    AK059799.1 


    ENSEMBL Gene Tree for RAB2A (if available)
    TreeFam Gene Tree for RAB2A (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RAB2A gene
    RAB39A2  RAB252  RAB142  RAB4B2  RAB39B2  RAB11B2  RAB422  RAB4A2  
    RAB11A2  RAB2B2  
    18/101 SIMAP similar genes for RAB2A using alignment to 5 protein entries:     RAB2A_HUMAN (see all proteins) (see all similar genes):
    DKFZp313C1541    RAB2B    RAB14    RAB4B    RAB4A    RAB19
    RAB8B    RAB37    RAB8A    RAB13    RAB30    DKFZp686J06205
    RAB15    RAB43    RAB11B    RAB39A    RAB6A    RAB11A

    RAB2A for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for RAB2A
    PGOHUM00000239818


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1922 NCBI SNPs in RAB2A are shown (see all 1922    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs113002281,2
    C,--56919305(+) CACTG-/TTATAG 1 -- int12Minor allele frequency- T:0.00NA CSA 4
    rs794089221,2
    C,F,--61427581(+) GAGAGT/CGAAGA 2 -- us2k11Minor allele frequency- C:0.03EA 120
    rs1806734681,2
    --61427703(+) TAAAGC/GTGAAT 2 -- us2k10--------
    rs1169916651,2
    --61427850(+) CATCCA/GAAGCA 2 -- us2k11Minor allele frequency- G:0.01NA 120
    rs1386245291,2
    --61427875(+) CATGAC/TGGTGT 2 -- us2k10--------
    rs1415856751,2
    --61427891(+) CTAATC/TACATA 2 -- us2k10--------
    rs1853892111,2
    --61427920(+) AAGAGA/TATTAG 2 -- us2k10--------
    rs1901203431,2
    --61428112(+) CCCTCC/TCCAAA 2 -- us2k10--------
    rs2020243531,2
    --61428199(+) TGACA-/CCCTATT 2 -- us2k10--------
    rs23265621,2
    C,F,A,H,--61428200(-) AATAGA/GGTGTC 2 -- us2k113Minor allele frequency- G:0.36NS EA NA WA CSA 781

    HapMap Linkage Disequilibrium report for RAB2A (61429416 - 61536186 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for RAB2A: --
    Human Gene Mutation Database (HGMD): RAB2A

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAB2A
    DNA2.0 Custom Variant and Variant Library Synthesis for RAB2A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    RAB2A for disorders           About GeneDecksing

    OMIM gene information: 179509    OMIM disorders: --

    8 diseases for RAB2A:    About MalaCards
    duane retraction syndrome    vaginal cancer    stomatitis    insulinoma
    vaginitis    pheochromocytoma    pancreatitis    malaria

    2 diseases from the University of Copenhagen DISEASES database for RAB2A:
    Duane retraction syndrome     Vaginal cancer

    1 Novoseek disease relationship for RAB2A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sezary syndrome 79.3 2 8096558 (1), 8511040 (1)

    Human Genome Epidemiology (HuGE) Navigator: RAB2A (2 documents)

    Export disorders for RAB2A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RAB2A gene, integrated from 9 sources (see all 44):
    (articles sorted by number of sources associating them with RAB2A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (2006)
    2. Structural basis of family-wide Rab GTPase recognition by rabenosyn- 5. (PubMed id 16034420)1, 2 Eathiraj S.... Lambright D.G. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Rab2 interacts directly with atypical protein kinase C (aPKC) iota/lambda and inhibits aPKCiota/lambda-dependent glyceraldehyde-3- phosphate dehydrogenase phosphorylation. (PubMed id 14570876)1, 2 Tisdale E.J. (2003)
    5. Isoprenoid modification of rab proteins terminating in CC or CXC motifs. (PubMed id 1648736)1, 2 Khosravi-Far R.... Der C.J. (1991)
    6. The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion. (PubMed id 2501306)1, 2 Zahraoui A.... Tavitian A. (1989)
    7. Nucleotide sequence of a new YPT1-related human cDNA which belongs to the ras gene superfamily. (PubMed id 3057444)1, 2 Tachibana K.... Takano T. (1988)
    8. Regulation of anterograde transport of adrenergic and angiotensin II receptors by Rab2 and Rab6 GTPases. (PubMed id 17716866)1, 9 Dong C. and Wu G. (2007)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5862 HGNC: 9763 AceView: RAB2 Ensembl:ENSG00000104388 euGenes: HUgn5862
    ECgene: RAB2A H-InvDB: RAB2A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RAB2A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RAB2A gene:
    Search GeneIP for patents involving RAB2A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for RAB2A   OriGene shRNA RFP for RAB2A  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAB2A   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAB2A  
     OriGene Protein Over-expression Lysate for RAB2A   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for RAB2A   OriGene 3'-UTR Clone for RAB2A  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAB2A   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAB2A  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for RAB2A   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RAB2A   OriGene Custom Protein Services for RAB2A  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RAB2A
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAB2A
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB2A
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAB2A
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAB2A
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAB2A
     GenScript Custom Purified and Recombinant Proteins Services for RAB2A GenScript cDNA clones with any tag delivered in your preferred vector for RAB2A
     GenScript Custom Assay Services for RAB2A GenScript Custom Superior Antibodies Services for RAB2A
     GenScript Custom overexpressing Cell Line Services for RAB2A CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in RAB2A promoter
     Search Chromatin IP Primers for RAB2A
     RT2 qPCR Primer Assay in human, mouse, rat RAB2A
     GNC Network for RAB2A
     SABiosciences Custom PCR Arrays for RAB2A
     Search Tocris compounds for RAB2A
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     RAB2A antibodies
     RAB2A proteins
     RAB2A lysates
     Antibodies for RAB2A
     See all of Abcam's Antibodies, Kits and Proteins for RAB2A
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for RAB2A




     RAB2A Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for RAB2A
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB2A
     SwitchGear 3'UTR luciferase reporter plasmids for RAB2A
     SwitchGear Promoter luciferase reporter plasmids for RAB2A
     ThermoFisher Antibody for RAB2A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB2A
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RAB2A gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4