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Aliases & Descriptions for RAB2A
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| | | Descriptions |
|---|
| RAB2, member RAS oncogene family 1, 2 | | RAB2A, member RAS oncogene family 2 | | small GTP binding protein RAB2A 2 |
|
| | Search outside databases for aliases for RAB2A gene |
Summaries for RAB2A(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for RAB2A: Members of the Rab protein family are nontransforming monomeric GTP-binding proteins of the Ras superfamily that contain 4 highly conserved regions involved in GTP binding and hydrolysis. Rabs are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking. The mammalian RAB proteins show striking similarities to the S. cerevisiae YPT1 and SEC4 proteins, Ras-related GTP-binding proteins involved in the regulation of secretion.[supplied by OMIM] UniProtKB/Swiss-Prot: RAB2A_HUMAN, P61019Function: Required for protein transport from the endoplasmic reticulum to the Golgi complexGene Wiki entry for RAB2A |
Genomic Location for RAB2A
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q12.1 Ensembl cytogenetic band: 8q12.1 HGNC cytogenetic band: 8q12.1RAB2A Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08P061593:
(about GC identifiers)
Start:
|
61,592,113 bp from pter |
End:
|
61,696,183 bp from pter |
Size:
|
104,071 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000008.9 NT_008183.18
| Proteins for RAB2A
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: RAB2A_HUMAN, P61019 (See
protein sequence)Recommended Name: Ras-related protein Rab-2A Size: 212 amino acids; 23546 Da
Subunit: Interacts with PRKCI
Subcellular location: Endoplasmic reticulum-Golgi intermediate compartment membrane; Lipid-anchor. Melanosome. Endoplasmic reticulum membrane; Lipid-anchor (Potential). Golgi apparatus membrane; Lipid-anchor (Potential). Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV
PDB structures from and Proteopedia :1Z0A (3D)
 
Secondary accessions: P08886Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_002856.1
ENSEMBL proteins: ENSP00000379924 ENSP00000379925 ENSP00000262646
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: RAB2A 
5/7 Gene Ontology (GO) cellular component terms (links to tree view) (see all 7
): About this table
Antibodies for RAB2A: Assays for RAB2A: | Protein
Domains/ Families for RAB2A(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P61019
ProtoNet protein and cluster: P61019 4 Blocks protein families: IPB001806 Transforming protein P21 RAS signature IPB002041 GTP-binding nuclear protein Ran IPB003577 Ras small GTPase IPB003578 Ras small GTPase
UniProtKB/Swiss-Prot: RAB2A_HUMAN, P61019Similarity: Belongs to the small GTPase superfamily. Rab family | Gene Function for RAB2A
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002865
Applied Biosystems Silencer® siRNAs for RAB2A
Sigma-Aldrich siRNA for RAB2A  Sigma-Aldrich shRNA for RAB2A  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002865                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_002865                                  untagged cDNA clone in CMV expression vector: NM_002865 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_002865
UniProtKB/Swiss-Prot: RAB2A_HUMAN, P61019Function: Required for protein transport from the endoplasmic reticulum to the Golgi complex3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for RAB2A
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for RAB2A 
5/11 Interacting proteins for RAB2A (P610192 ENSP000002626463) via UniProtKB, MINT, and/or STRING (see all 11
)About this table
4 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006888 | ER to Golgi vesicle-mediated transport |
TAS | 8910601 | | GO:0007264 | small GTPase mediated signal transduction |
IEA | -- | | GO:0015031 | protein transport |
IEA | -- | | GO:0016192 | vesicle-mediated transport |
IEA | -- | About this table
|
Drugs & Compounds for RAB2A(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for RAB2A 2 Novoseek chemical compound relationships for RAB2A gene
About this table
|
Transcripts for RAB2A(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002865
Sigma-Aldrich siRNA for RAB2A  Sigma-Aldrich shRNA for RAB2A  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_002865 REFSEQ mRNAs for RAB2A gene: NM_002865.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_002865               OriGene GFP tagged cDNA clone in CMV expression vector: NM_002865                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_002865                                  untagged cDNA clone in CMV expression vector: NM_002865  Additional cDNA sequence: AF070629.1 AF498930.1 AK297576.1 AK312344.1 AL137321.1 AY034106.1 BC008929.2 BT019695.1 CR605346.1 CR624395.1 M28213.1 S48723.1 X12953.1 24/32 DOTS entries (see all 32
): DT.121465159 DT.92447379 DT.75160557 DT.100828439 DT.121465184 DT.100828440 DT.91897065 DT.100037921 DT.100828441 DT.91743610 DT.100778514 DT.121465125 DT.450288 DT.95344436 DT.100693540 DT.100828437 DT.102833609 DT.121465115 DT.121465150 DT.121465170 DT.121465174 DT.121465182 DT.121465209 DT.121465210 24/508 AceView cDNA sequences (see all 508
):CB241252 CB128846 BM793987 CA841655 AI800540 CB150602 BM559855 H96991 CB150242 BM835858 X12953 CA848385 AI312834 AU118172 BC008929 BF038471 BF437914 CR605346 BF968076 BM817586 AI791989 BU739368 BP378891 BU687490
highest scoring ESTs for RAB2A:M28213 AA064936 AA096405 AA113275 AA128137 AA149772 AA229908 AA252343 AA331035 AA400515 Unigene Cluster for RAB2A: RAB2A, member RAS oncogene family Hs.369017 [show with all ESTs]Unigene Representative Sequence: AL137321
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for RAB2A
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | |
| SP1: | |   | |   | |   | - |   | |   | - |   | |   | |   | - |   | |   | - |   | |   | |   | |
| SP2: | |   | |   | |   | - |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | - |   | |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for RAB2A
3 Ensembl transcripts including schematic representations: ENST00000396696
ENST00000396697
ENST00000262646
|
Expression for RAB2A
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| RAB2A expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for RAB2A
1 / 2 / 3 7 probe-sets matching RAB2A gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: CAGGACAGTT
SOURCE GeneReport for Unigene cluster: Hs.369017
|
Orthologs for RAB2A
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for RAB2A gene from 5/20 species (see all 20
)
About this table Species with no ortholog for RAB2A
ENSEMBL Gene Tree for RAB2A | Paralogs for RAB2A(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for RAB2A gene
- RAB142 RAB4A2 RAB4B2 RAB2B2
|
SNPs/Variants for RAB2A(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for RAB2A (up to first 250kb)
|
Disorders & Mutations for RAB2A
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 179509
1 Novoseek disease relationship for RAB2A gene
About this table
|
Medical News for RAB2A(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for RAB2A (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/29 PubMed articles for RAB2A gene (see all 29
): |
Search for RAB2A
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing RAB2A
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing RAB2A
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RAB2A(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for RAB2A(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for RAB2A:

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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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