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Aliases for RAB2A Gene

Aliases for RAB2A Gene

  • RAB2A, Member RAS Oncogene Family 2 3 5
  • RAB2, Member RAS Oncogene Family 2 3
  • RAB2 3 4
  • Small GTP Binding Protein RAB2A 3
  • LHX 3

External Ids for RAB2A Gene

Previous HGNC Symbols for RAB2A Gene

  • RAB2

Previous GeneCards Identifiers for RAB2A Gene

  • GC08P061593
  • GC08P061429
  • GC08P056918

Summaries for RAB2A Gene

Entrez Gene Summary for RAB2A Gene

  • The protein encoded by this gene belongs to the Rab family, members of which are small molecular weight guanosine triphosphatases (GTPases) that contain highly conserved domains involved in GTP binding and hydrolysis. The Rabs are membrane-bound proteins, involved in vesicular fusion and trafficking. This protein is a resident of pre-Golgi intermediates, and is required for protein transport from the endoplasmic reticulum (ER) to the Golgi complex. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for RAB2A Gene

RAB2A (RAB2A, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB2A include Sezary's Disease and Lipoblastoma. Among its related pathways are Mitotic Prophase and AMPK signaling pathway. GO annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB39A.

UniProtKB/Swiss-Prot for RAB2A Gene

  • Required for protein transport from the endoplasmic reticulum to the Golgi complex.

Gene Wiki entry for RAB2A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB2A Gene

Genomics for RAB2A Gene

Regulatory Elements for RAB2A Gene

Enhancers for RAB2A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RAB2A on UCSC Golden Path with GeneCards custom track

Promoters for RAB2A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RAB2A on UCSC Golden Path with GeneCards custom track

Genomic Location for RAB2A Gene

60,516,857 bp from pter
60,623,644 bp from pter
106,788 bases
Plus strand

Genomic View for RAB2A Gene

Genes around RAB2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB2A Gene

Proteins for RAB2A Gene

  • Protein details for RAB2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras-related protein Rab-2A
    Protein Accession:
    Secondary Accessions:
    • B2R5W8
    • B4DMQ5
    • P08886

    Protein attributes for RAB2A Gene

    212 amino acids
    Molecular mass:
    23546 Da
    Quaternary structure:
    • Interacts with PRKCI.

    Three dimensional structures from OCA and Proteopedia for RAB2A Gene

    Alternative splice isoforms for RAB2A Gene


neXtProt entry for RAB2A Gene

Proteomics data for RAB2A Gene at MOPED

Post-translational modifications for RAB2A Gene

  • Ubiquitination at Lys 165
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RAB2A Gene

Domains & Families for RAB2A Gene

Gene Families for RAB2A Gene

Suggested Antigen Peptide Sequences for RAB2A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Rab family.
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB2A: view

Function for RAB2A Gene

Molecular function for RAB2A Gene

UniProtKB/Swiss-Prot Function:
Required for protein transport from the endoplasmic reticulum to the Golgi complex.
genes like me logo Genes that share phenotypes with RAB2A: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB2A Gene

Localization for RAB2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB2A Gene

Endoplasmic reticulum-Golgi intermediate compartment membrane; Lipid-anchor. Melanosome. Endoplasmic reticulum membrane; Lipid-anchor. Golgi apparatus membrane; Lipid-anchor. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

Jensen Localization Image for RAB2A Gene COMPARTMENTS Subcellular localization image for RAB2A gene
Compartment Confidence
extracellular 5
golgi apparatus 5
lysosome 5
nucleus 5
vacuole 5
endoplasmic reticulum 4
cytosol 3
endosome 2
cytoskeleton 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RAB2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005634 nucleus IDA 21630459
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane IEA --
GO:0042470 melanosome IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with RAB2A: view

Pathways & Interactions for RAB2A Gene

genes like me logo Genes that share pathways with RAB2A: view

Pathways by source for RAB2A Gene

1 Qiagen pathway for RAB2A Gene

Gene Ontology (GO) - Biological Process for RAB2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0007030 Golgi organization IMP 17684057
GO:0007264 small GTPase mediated signal transduction IEA --
genes like me logo Genes that share ontologies with RAB2A: view

No data available for SIGNOR curated interactions for RAB2A Gene

Drugs & Compounds for RAB2A Gene

(2) Additional Compounds for RAB2A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RAB2A: view

Transcripts for RAB2A Gene

Unigene Clusters for RAB2A Gene

RAB2A, member RAS oncogene family:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAB2A Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9
SP1: - - - -
SP2: - -
SP3: - - -
SP4: -

Relevant External Links for RAB2A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RAB2A Gene

mRNA expression in normal human tissues for RAB2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB2A Gene

SOURCE GeneReport for Unigene cluster for RAB2A Gene Hs.369017

genes like me logo Genes that share expression patterns with RAB2A: view

Protein tissue co-expression partners for RAB2A Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RAB2A Gene

Orthologs for RAB2A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RAB2A Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia RAB2A 35
  • 96.23 (n)
  • 100 (a)
RAB2A 36
  • 91 (a)
(Mus musculus)
Mammalia Rab2a 35
  • 91.98 (n)
  • 98.58 (a)
Rab2a 16
Rab2a 36
  • 99 (a)
(Pan troglodytes)
Mammalia RAB2A 35
  • 100 (n)
  • 100 (a)
RAB2A 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rab2a 35
  • 92.14 (n)
  • 98.58 (a)
(Bos Taurus)
Mammalia RAB2A 36
  • 99 (a)
(Monodelphis domestica)
Mammalia RAB2A 36
  • 100 (a)
(Ornithorhynchus anatinus)
Mammalia RAB2A 36
  • 98 (a)
(Gallus gallus)
Aves RAB2A 35
  • 87.42 (n)
  • 99.53 (a)
RAB2A 36
  • 100 (a)
(Anolis carolinensis)
Reptilia RAB2A 36
  • 99 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rab2a 35
  • 83.16 (n)
  • 96.94 (a)
(Danio rerio)
Actinopterygii Dr.20914 35
rab2a 35
  • 81.76 (n)
  • 98.11 (a)
rab2a 36
  • 98 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.890 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005393 35
  • 72.93 (n)
  • 93.4 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rab2 35
  • 73.94 (n)
  • 93.91 (a)
Rab2 36
  • 90 (a)
(Caenorhabditis elegans)
Secernentea unc-108 35
  • 74.49 (n)
  • 92.35 (a)
unc-108 36
  • 87 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPT31 36
  • 41 (a)
YPT32 36
  • 39 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons RABB1C 35
  • 74.29 (n)
  • 84.57 (a)
(Glycine max)
eudicotyledons Gma.6653 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.232 35
(Hordeum vulgare)
Liliopsida Hv.10692 35
(Oryza sativa)
Liliopsida Os.8483 35
Os02g0586400 35
  • 71.45 (n)
  • 82.05 (a)
(Triticum aestivum)
Liliopsida Ta.5309 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5043 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.388 36
  • 90 (a)
Species with no ortholog for RAB2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RAB2A Gene

Gene Tree for RAB2A (if available)
Gene Tree for RAB2A (if available)

Paralogs for RAB2A Gene Pseudogenes for RAB2A Gene

genes like me logo Genes that share paralogs with RAB2A: view

Variants for RAB2A Gene

Sequence variations from dbSNP and Humsavar for RAB2A Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs2037964 -- 60,526,143(+) CAGAA(A/G)TCTAA intron-variant
rs2056414 -- 60,559,069(+) TTTTT(A/T)AAAAT intron-variant
rs2056415 -- 60,559,280(+) agcca(C/T)ttccc intron-variant
rs2128714 -- 60,619,704(-) CCTTT(C/T)AGATA intron-variant
rs2178953 -- 60,563,747(+) AATTA(C/G)TAACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB2A Gene

Variant ID Type Subtype PubMed ID
esv2737065 CNV Deletion 23290073
esv2737066 CNV Deletion 23290073
esv2737067 CNV Deletion 23290073
esv273735 CNV Insertion 20981092
esv269471 CNV Insertion 20981092
nsv6218 CNV Loss 18451855
esv2737068 CNV Deletion 23290073
nsv831335 CNV Loss 17160897
nsv890945 CNV Gain 21882294
esv270573 CNV Insertion 20981092
esv272923 CNV Insertion 20981092
esv1615811 CNV Insertion 17803354

Variation tolerance for RAB2A Gene

Residual Variation Intolerance Score: 56.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.10; 2.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAB2A Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB2A Gene

Disorders for RAB2A Gene

MalaCards: The human disease database

(4) MalaCards diseases for RAB2A Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
sezary's disease
  • sezary disease
image syndrome
  • intrauterine growth restriction, metaphyseal dysplasia, adrenal hypoplasia congenita, genital abnormalities
vaginal cancer
  • malignant neoplasm of vagina
- elite association - COSMIC cancer census association via MalaCards
Search RAB2A in MalaCards View complete list of genes associated with diseases

Relevant External Links for RAB2A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RAB2A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RAB2A Gene

Publications for RAB2A Gene

  1. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PMID: 17081065) Chi A. … Hunt D.F. (J. Proteome Res. 2006) 3 4 67
  2. Regulation of anterograde transport of adrenergic and angiotensin II receptors by Rab2 and Rab6 GTPases. (PMID: 17716866) Dong C. … Wu G. (Cell. Signal. 2007) 3 23
  3. The Rab2A GTPase promotes breast cancer stem cells and tumorigenesis via Erk signaling activation. (PMID: 25818297) Luo M.L. … Lu K.P. (Cell Rep 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for RAB2A Gene

Sources for RAB2A Gene