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Aliases for RAB29 Gene

Aliases for RAB29 Gene

  • RAB29, Member RAS Oncogene Family 2 3
  • RAB7L1 3 4 6
  • RAB7, Member RAS Oncogene Family-Like 1 2 3
  • Ras-Related Protein Rab-29 3 4
  • Rab-7-Like Protein 1 3 4
  • Ras-Related Protein Rab-7L1 3
  • RAB7L 3

External Ids for RAB29 Gene

Previous Symbols for RAB29 Gene

  • RAB7L
  • RAB7L1

Summaries for RAB29 Gene

GeneCards Summary for RAB29 Gene

RAB29 (RAB29, Member RAS Oncogene Family) is a Protein Coding gene. An important paralog of this gene is RAB9A.

UniProtKB/Swiss-Prot for RAB29 Gene

  • Rab GTPase key regulator in vesicle trafficking. Essential for maintaining the integrity of the endosome-trans-Golgi network structure. Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). May play a role in the formation of typhoid toxin transport intermediates during Salmonella enterica serovar Typhi (S.Typhi) epithelial cell infection.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB29 Gene

Genomics for RAB29 Gene

Genomic Location for RAB29 Gene

Start:
205,767,986 bp from pter
End:
205,775,487 bp from pter
Size:
7,502 bases
Orientation:
Minus strand

Genomic View for RAB29 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAB29 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB29 Gene

No data available for Regulatory Elements for RAB29 Gene

Proteins for RAB29 Gene

  • Protein details for RAB29 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14966-RAB7L_HUMAN
    Recommended name:
    Ras-related protein Rab-7L1
    Protein Accession:
    O14966
    Secondary Accessions:
    • B4E1K3
    • C9JE77

    Protein attributes for RAB29 Gene

    Size:
    203 amino acids
    Molecular mass:
    23155 Da
    Quaternary structure:
    • Interacts with LRRK2.

    Alternative splice isoforms for RAB29 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAB29 Gene

Proteomics data for RAB29 Gene at MOPED

Post-translational modifications for RAB29 Gene

  • In case of Salmonella enterica serovar Typhimurium (S.Typhimurium) infection, is proteolytically cleaved between Gly-41 and Val-42 by the GtgE viral protease encoded on the Gifsy-2 lysogen bacteriophage, which therefore prevents the recruitment of RAB29 to S.Typhimurium-containing vacuoles. In contrast, no proteolytically cleavage is detected in S.Typhi-infected cells (PubMed:22042847).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RAB29 Gene

Domains for RAB29 Gene

Gene Families for RAB29 Gene

HGNC:
  • RAB :RAB, member RAS oncogene

UniProtKB/Swiss-Prot:

RAB7L_HUMAN
Family:
  • Belongs to the small GTPase superfamily. Rab family.:
    • O14966
genes like me logo Genes that share domains with RAB29: view

Function for RAB29 Gene

Molecular function for RAB29 Gene

UniProtKB/Swiss-Prot Function: Rab GTPase key regulator in vesicle trafficking. Essential for maintaining the integrity of the endosome-trans-Golgi network structure. Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). May play a role in the formation of typhoid toxin transport intermediates during Salmonella enterica serovar Typhi (S.Typhi) epithelial cell infection.

Gene Ontology (GO) - Molecular Function for RAB29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity TAS 9284931
GO:0005515 protein binding IPI 24510904
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RAB29: view
genes like me logo Genes that share phenotypes with RAB29: view

miRNA for RAB29 Gene

miRTarBase miRNAs that target RAB29

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RAB29 Gene

Localization for RAB29 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB29 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus. Golgi apparatus, trans-Golgi network. Vacuole. Cytoplasm, cytoskeleton. Note=Colocalizes with LRRK2 along tubular structures emerging from Golgi apparatus (By similarity). Colocalizes with GM130 at the Golgi apparatus. Colocalizes with dynamic tubules emerging from and retracting to the Golgi apparatus. Colocalizes with TGN46 at the trans-Golgi network (TGN). In Salmonella enterica serovar Typhi (S.Typhi) infected epithelial cells, is recruited and colocalized with both S.Typhi-containing vacuoles and dynamic tubules as well as those emerging from the vacuole toward the cell periphery. {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for RAB29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005737 cytoplasm IDA 24788816
GO:0005739 NOT mitochondrion IBA --
GO:0005773 vacuole IEA --
genes like me logo Genes that share ontologies with RAB29: view

Pathways for RAB29 Gene

SuperPathways for RAB29 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RAB29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport --
GO:0006888 NOT ER to Golgi vesicle-mediated transport IMP 24788816
GO:0006913 nucleocytoplasmic transport --
GO:0007030 Golgi organization IMP 24788816
genes like me logo Genes that share ontologies with RAB29: view

No data available for Pathways by source for RAB29 Gene

Transcripts for RAB29 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for RAB29 Gene

No ASD Table

Relevant External Links for RAB29 Gene

GeneLoc Exon Structure for
RAB29
ECgene alternative splicing isoforms for
RAB29

Expression for RAB29 Gene

mRNA expression in normal human tissues for RAB29 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RAB29 Gene

mRNA Expression by UniProt/SwissProt for RAB29 Gene

O14966-RAB7L_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with RAB29: view

Orthologs for RAB29 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RAB29 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB7L1 36
  • 99.84 (n)
  • 100 (a)
RAB7L1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RAB7L1 36
  • 94.39 (n)
  • 95.54 (a)
RAB7L1 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAB7L1 36
  • 91.91 (n)
  • 94.55 (a)
RAB7L1 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rab7l1 36
  • 90.97 (n)
  • 93.6 (a)
Rab7l1 16
Rab7l1 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAB7L1 37
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAB7L1 37
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rab7l1 36
  • 89.33 (n)
  • 94.09 (a)
chicken
(Gallus gallus)
Aves RAB7L1 36
  • 75.53 (n)
  • 79.31 (a)
RAB7L1 37
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAB7L1 37
  • 75 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.32195 36
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100135159 36
  • 68.97 (n)
  • 70.94 (a)
zebrafish
(Danio rerio)
Actinopterygii si:ch73-173m3.3 37
  • 46 (a)
ManyToMany
Species with no ortholog for RAB29:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAB29 Gene

ENSEMBL:
Gene Tree for RAB29 (if available)
TreeFam:
Gene Tree for RAB29 (if available)

Paralogs for RAB29 Gene

Paralogs for RAB29 Gene

genes like me logo Genes that share paralogs with RAB29: view

Variants for RAB29 Gene

Sequence variations from dbSNP and Humsavar for RAB29 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs708723 -- 205,770,138(+) GTGAG(C/T)CAGCA utr-variant-3-prime
rs708724 -- 205,774,535(+) CCTGC(A/C)ATAAA intron-variant
rs708725 -- 205,775,010(+) CGGGG(A/C/G/T)TCGCT utr-variant-5-prime, intron-variant
rs823132 -- 205,768,636(+) TCAAG(C/T)GATTC utr-variant-3-prime
rs823133 -- 205,768,653(+) CTCAG(C/T)CTCCC utr-variant-3-prime

Relevant External Links for RAB29 Gene

HapMap Linkage Disequilibrium report
RAB29
Human Gene Mutation Database (HGMD)
RAB29

No data available for Structural Variations from Database of Genomic Variants (DGV) for RAB29 Gene

Disorders for RAB29 Gene

No disorders were found for RAB29 Gene.

No data available for UniProtKB/Swiss-Prot for RAB29 Gene

Publications for RAB29 Gene

  1. Cloning and chromosome assignment to 1q32 of a human cDNA (RAB7L1) encoding a small GTP-binding protein, a member of the RAS superfamily. (PMID: 9284931) Shimizu F. … Takahashi E. (Cytogenet. Cell Genet. 1997) 2 3 4 23
  2. Thousands of rab GTPases for the cell biologist. (PMID: 22022256) Diekmann Y. … Pereira-Leal J.B. (PLoS Comput. Biol. 2011) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. A role of rab29 in the integrity of the trans-Golgi network and retrograde trafficking of mannose-6-phosphate receptor. (PMID: 24788816) Wang S. … Wang T. (PLoS ONE 2014) 3 4
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for RAB29 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate RAB29
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for RAB29
    • Block miRNA regulation of RAB29 using miScript Target Protectors

    Sources for RAB29 Gene

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