Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RAB28 Gene

Aliases for RAB28 Gene

  • RAB28, Member RAS Oncogene Family 2 3
  • CORD18 3 6
  • Ras-Related Protein Rab-28 3

External Ids for RAB28 Gene

Previous GeneCards Identifiers for RAB28 Gene

  • GC04M013212
  • GC04U900009
  • GC04M013057
  • GC04M013120
  • GC04M013045
  • GC04M012707

Summaries for RAB28 Gene

Entrez Gene Summary for RAB28 Gene

  • This gene encodes a member of the Rab subfamily of Ras-related small GTPases. The encoded protein may be involved in regulating intracellular trafficking. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 9 and X. [provided by RefSeq, Apr 2009]

GeneCards Summary for RAB28 Gene

RAB28 (RAB28, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB28 include cone-rod dystrophy 18 and cone-rod dystrophy 6. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include GTP binding and GDP binding.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB28 Gene

Genomics for RAB28 Gene

Regulatory Elements for RAB28 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RAB28 Gene

13,342,239 bp from pter
13,484,365 bp from pter
142,127 bases
Minus strand

Genomic View for RAB28 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAB28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB28 Gene

Proteins for RAB28 Gene

  • Protein details for RAB28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras-related protein Rab-28
    Protein Accession:
    Secondary Accessions:
    • G8JLC5
    • Q8IYR8
    • Q8NI05

    Protein attributes for RAB28 Gene

    221 amino acids
    Molecular mass:
    24841 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RAB28 Gene

    Alternative splice isoforms for RAB28 Gene


neXtProt entry for RAB28 Gene

Proteomics data for RAB28 Gene at MOPED

Post-translational modifications for RAB28 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for RAB28

No data available for DME Specific Peptides for RAB28 Gene

Domains for RAB28 Gene

Gene Families for RAB28 Gene

  • RAB :RAB, member RAS oncogene

Protein Domains for RAB28 Gene

Suggested Antigen Peptide Sequences for RAB28 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P51157
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB28: view

Function for RAB28 Gene

Gene Ontology (GO) - Molecular Function for RAB28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity TAS 8647132
GO:0005525 GTP binding IDA 19026641
GO:0019003 GDP binding IDA 19026641
genes like me logo Genes that share ontologies with RAB28: view
genes like me logo Genes that share phenotypes with RAB28: view

Animal Model Products

miRNA for RAB28 Gene

miRTarBase miRNAs that target RAB28

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAB28

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RAB28 Gene

Localization for RAB28 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB28 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytoskeleton, cilium basal body. Note=Expressed in the basal body and ciliary rootlet of the photoreceptors. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for RAB28 Gene COMPARTMENTS Subcellular localization image for RAB28 gene
Compartment Confidence
plasma membrane 5
cytosol 3
cytoskeleton 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RAB28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with RAB28: view

Pathways for RAB28 Gene

genes like me logo Genes that share pathways with RAB28: view

Pathways by source for RAB28 Gene

1 Qiagen pathway for RAB28 Gene

Interacting Proteins for RAB28 Gene

Gene Ontology (GO) - Biological Process for RAB28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport --
GO:0006913 nucleocytoplasmic transport --
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction IEA --
genes like me logo Genes that share ontologies with RAB28: view

Transcripts for RAB28 Gene

Unigene Clusters for RAB28 Gene

RAB28, member RAS oncogene family:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAB28

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB28 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: - -
SP2: - - - -
SP3: -

Relevant External Links for RAB28 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RAB28 Gene

mRNA expression in normal human tissues for RAB28 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for RAB28 Gene

This gene is overexpressed in Retina (23.4) and Ovary (8.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB28 Gene

SOURCE GeneReport for Unigene cluster for RAB28 Gene Hs.656060

mRNA Expression by UniProt/SwissProt for RAB28 Gene

Tissue specificity: Isoform S is detected in most tissues investigated: cortex, liver, kidney, skeletal muscle, adipose tissue, testis, urothelium, lung, bone marrow and retinal pigment epithelium (RPE). Isoform L 2 is widely and abundantly expressed all tissues. Isoform 3 is highly expressed in heart, lung, bone marrow, retina, brain, and RPE.
genes like me logo Genes that share expressions with RAB28: view

Expression partners for RAB28 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for RAB28 Gene

Orthologs for RAB28 Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB28 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RAB28 35
  • 95.78 (n)
  • 96.38 (a)
RAB28 36
  • 96 (a)
(Canis familiaris)
Mammalia RAB28 35
  • 95.48 (n)
  • 96.38 (a)
RAB28 36
  • 94 (a)
(Mus musculus)
Mammalia Rab28 35
  • 92.01 (n)
  • 95.48 (a)
Rab28 16
Rab28 36
  • 95 (a)
(Pan troglodytes)
Mammalia RAB28 35
  • 99.66 (n)
  • 100 (a)
RAB28 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rab28 35
  • 92.61 (n)
  • 96.38 (a)
(Monodelphis domestica)
Mammalia RAB28 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia RAB28 36
  • 66 (a)
(Gallus gallus)
Aves RAB28 35
  • 83.56 (n)
  • 86.88 (a)
RAB28 36
  • 86 (a)
(Anolis carolinensis)
Reptilia RAB28 36
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rab28 35
  • 78.88 (n)
  • 85.07 (a)
Str.15168 35
(Danio rerio)
Actinopterygii rab28 35
  • 73.91 (n)
  • 82.35 (a)
wufe49e06 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3434 35
(Caenorhabditis elegans)
Secernentea rab-28 35
  • 50.84 (n)
  • 48.4 (a)
rab-28 36
  • 42 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
Species with no ortholog for RAB28:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB28 Gene

Gene Tree for RAB28 (if available)
Gene Tree for RAB28 (if available)

Paralogs for RAB28 Gene

genes like me logo Genes that share paralogs with RAB28: view

No data available for Paralogs for RAB28 Gene

Variants for RAB28 Gene

Sequence variations from dbSNP and Humsavar for RAB28 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs2184 -- 13,481,618(+) GACAG(A/G)AAAAA intron-variant
rs3520 -- 13,365,098(+) GGAGC(C/T)AGAAG intron-variant
rs15412 -- 13,367,805(-) TTCTC(A/C/G/T)GGAGT utr-variant-3-prime, intron-variant
rs1008242 -- 13,352,950(-) ACACT(C/T)TTTTG intron-variant
rs1008243 -- 13,352,860(-) AAGGC(A/C)CACAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB28 Gene

Variant ID Type Subtype PubMed ID
nsv829866 CNV Loss 17160897
esv2665157 CNV Deletion 23128226
esv25888 CNV Loss 19812545

Relevant External Links for RAB28 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB28 Gene

Disorders for RAB28 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for RAB28 Gene in MalaCards »

(2) Diseases for RAB28 Gene including...

(1) OMIM Diseases for RAB28 Gene (612994)


  • Cone-rod dystrophy 18 (CORD18) [MIM:615374]: A form of cone-rod dystrophy, an inherited retinal dystrophy characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa. {ECO:0000269 PubMed:23746546}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for RAB28

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with RAB28: view

No data available for University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for RAB28 Gene

Publications for RAB28 Gene

  1. Alternative mRNA splicing of the novel GTPase Rab28 generates isoforms with different C-termini. (PMID: 8647132) Brauers A. … Joost H.-G. (Eur. J. Biochem. 1996) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Towards complete sets of farnesylated and geranylgeranylated proteins. (PMID: 17411337) Maurer-Stroh S. … Eisenhaber F. (PLoS Comput. Biol. 2007) 3 4
  4. Mutations in RAB28, encoding a farnesylated small GTPase, are associated with autosomal-recessive cone-rod dystrophy. (PMID: 23746546) Roosing S. … den Hollander A.I. (Am. J. Hum. Genet. 2013) 3 4
  5. Large nucleotide-dependent conformational change in Rab28. (PMID: 19026641) Lee S.H. … Dominguez R. (FEBS Lett. 2008) 3 4

Products for RAB28 Gene

Sources for RAB28 Gene

Back to Top