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Aliases & Descriptions for RAB28
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases MGC41862 2 Rab-26 3
Descriptions RAB28, member RAS oncogene family 2 Ras-related protein Rab-28 2
Search outside databases for aliases for RAB28 genePrevious GC identifers: GC04M013212 GC04U900009 GC04M013057 GC04M013120
Summaries for RAB28 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for RAB28 : This gene encodes a member of the Rab subfamily of Ras-related small GTPases. The encoded proteinmay be involved in regulating intracellular trafficking. Alternative splicing results in multipletranscript variants. Pseudogenes of this gene are found on chromosomes 9 and X. [provided byRefSeq]
Genomic Location for RAB28
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the RAB28 gene Entrez Gene cytogenetic band: 4p15.33 Ensembl cytogenetic band: 4p15.33 HGNC cytogenetic band: 4p16.1 RAB28 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure
GeneLoc location for GC04M013045:
(about GC identifiers )
Start:
12,978,447 bp from pter
End:
13,095,060 bp from pter
Size:
116,614 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000004.10 NT_006316.15 Proteins for RAB28
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: RAB28_HUMAN, P51157 (See
protein sequence )Recommended Name: Ras-related protein Rab-28 Size : 221 amino acids; 24841 Da
Subcellular location : Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
PDB structure from and Proteopedia : 2HXS (3D)
 3E5H (3D)
 
Secondary accessions : Q8IYR8 Q8NI05Alternative splicing : 2 isoforms : P51157-1 P51157-2
REFSEQ proteins (3 alternative transcripts):
NP_001017979.1 NP_001153073.1 NP_004240.2 ENSEMBL proteins: ENSP00000288723 ENSP00000340079 ENSP00000349060 ENSP00000328551 Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: RAB28 1 Gene Ontology (GO) cellular component term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0005886 plasma membrane
IEA --
About this table Antibodies for RAB28: Assays for RAB28:
Protein
Domains/ Families for RAB28(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry P51157 ProtoNet protein and cluster: P51157
1 Blocks protein family : IPB001806 Transforming protein P21 RAS signature UniProtKB/Swiss-Prot: RAB28_HUMAN, P51157 Similarity : Belongs to the small GTPase superfamily. Rab family
Gene Function for RAB28
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_001017979 Applied Biosystems Silencer ® siRNAs for RAB28 Sigma-Aldrich siRNA for RAB28 Sigma-Aldrich shRNA for RAB28 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001017979                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001017979                                  untagged cDNA clones in CMV expression vector (see all 3 ): BC018067  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001017979 3 Gene Ontology (GO) molecular function terms (links to tree view) :
About this table
Pathways & Interactions for RAB28
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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--1 Gene Ontology (GO) biological process term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0007264 small GTPase mediated signal transduction
IEA --
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Drugs & Compounds for RAB28 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Enzo Life Sciences drugs & compounds for RAB28
Browse Tocris compounds for RAB28
Transcripts for RAB28(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
Tagged/untagged cDNA clones from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_001017979 Sigma-Aldrich siRNA for RAB28 Sigma-Aldrich shRNA for RAB28 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001017979 NM_004249
REFSEQ mRNAs for RAB28 gene (3 alternative transcripts): NM_001017979.2 NM_001159601.1 NM_004249.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001017979 NM_004249
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001017979                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001017979                                  untagged cDNA clones in CMV expression vector (see all 3 ): BC018067  
Additional cDNA sequence: AF498955.1 BC018067.1 BC035054.2 BX537681.1 CR592237.1 CR597076.1 CR612152.1 CR616293.1 CR621879.1 X94703.1
12 DOTS entries : DT.95074907 DT.217999 DT.91923892 DT.217998 DT.95309902 DT.100008711 DT.121251983 DT.91747764 DT.95181071 DT.121252012 DT.40274367 DT.95309905
24/111 AceView cDNA sequences (see all 111
):CR612152 BQ021120 CR592237 BU742941 AI215961 Z41536 N46403 AI015919 AK027027 BM801937 AI689194 CR621879 N50159 AI084521 CR616293 CF456155 BU630749 AA666268 BM920172 Z45911 N49476 BU172445 W72006 BM832340
highest scoring ESTs for RAB28 :X94703 AF498955 BC018067 BG706085 CB565910 N37088 R52316 AA134142 AA666268 AI084521
Unigene Cluster for RAB28: RAB28, member RAS oncogene family Hs.656060 [show with all ESTs ] Unigene Representative Sequence: BX537681 GeneLoc Exon Structure 4 Alternative Splicing Database (ASD) splice patterns (SP) for RAB28 ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b SP1 :               -   -       SP2 :       -   -       -   -       SP3 :               -         SP4 :                      
About this scheme ECgene alternative splicing isoforms for RAB28 4 Ensembl transcripts including schematic representations : ENST00000288723
ENST00000338176
ENST00000356643
ENST00000330852
Expression for RAB28
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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RAB28 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for RAB28 1 / 2 / 3
8 probe-sets matching RAB28 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: TCGGACTCTGSOURCE GeneReport for Unigene cluster: Hs.656060 Expression variation in blood from EXPOLDB for RAB28
UniProtKB/Swiss-Prot: RAB28_HUMAN, P51157 Tissue specificity : Isoform S is detected in most tissues investigated (cortex, liver, kidney,skeletal muscle, adipose tissue, testis and urothelium), whereas isoform L is predominant intestis
Orthologs for RAB28
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for RAB28 gene from 5/10 species (see all 10
)
About this table Species with no ortholog for RAB28 ENSEMBL Gene Tree for RAB28 Paralogs for RAB28 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Pseudogenes 1 related pseudogene
SNPs/Variants for RAB28 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for RAB28 (up to first 250kb)
Disorders & Mutations for RAB28
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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--
Medical News for RAB28 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for RAB28 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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8 PubMed articles for RAB28 gene :
Search for RAB28
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing RAB28
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing RAB28
(According to HUGE )
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Specialized Databases showing RAB28 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for RAB28 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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