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RAB27B Gene

protein-coding   GIFtS: 62
GCID: GC18P052385

RAB27B, Member RAS Oncogene Family

  See RAB27B-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RAB27B, Member RAS Oncogene Family1 2
C25KG2 3
Ras-Related Protein Rab-27B2

External Ids:    HGNC: 97671   Entrez Gene: 58742   Ensembl: ENSG000000413537   OMIM: 6038695   UniProtKB: O001943   

Export aliases for RAB27B gene to outside databases

Previous GC identifers: GC18P052584 GC18P052398 GC18P052280 GC18P050644 GC18P050646 GC18P052495 GC18P049204


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RAB27B Gene:
Members of the Rab protein family, including RAB27B, are prenylated, membrane-bound proteins involved in vesicular
fusion and trafficking (Chen et al., 1997 (PubMed 9066979)).(supplied by OMIM, Nov 2010)

GeneCards Summary for RAB27B Gene:
RAB27B (RAB27B, member RAS oncogene family) is a protein-coding gene. Diseases associated with RAB27B include griscelli syndrome, and birt-hogg-dube syndrome. GO annotations related to this gene include GTP binding and protein domain specific binding. An important paralog of this gene is RAB27A.

UniProtKB/Swiss-Prot: RB27B_HUMAN, O00194
Function: May be involved in targeting uroplakins to urothelial apical membranes (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000018.9  NT_010966.15  NC_018929.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RAB27B gene promoter:
         Oct-B1   oct-B3   oct-B2   p53   POU6F1 (c2)   Ik-3   Gfi-1   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRAB27B promoter sequence
   Search Chromatin IP Primers for RAB27B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RAB27B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.2   Ensembl cytogenetic band:  18q21.2   HGNC cytogenetic band: 18q21.2

RAB27B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAB27B gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P052385:  view genomic region     (about GC identifiers)

Start:
52,385,091 bp from pter      End:
52,562,747 bp from pter
Size:
177,657 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RB27B_HUMAN, O00194 (See protein sequence)
Recommended Name: Ras-related protein Rab-27B  
Size: 218 amino acids; 24608 Da
Subunit: Interacts with SYTL2, SYTL4, MYRIP and MLPH. Interacts with RPH3A and RPH3A (By similarity)
1 PDB 3D structure from and Proteopedia for RAB27B:
2F7S (3D)    
Secondary accessions: B2RAB0 Q9BZB6

Explore the universe of human proteins at neXtProt for RAB27B: NX_O00194

Explore proteomics data for RAB27B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RAB27B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004154.2  
    ENSEMBL proteins: 
     ENSP00000468542   ENSP00000262094   ENSP00000465009  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RAB: RAB, member RAS oncogene

    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR003579 Small_GTPase_Rab_type
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry O00194

    ProtoNet protein and cluster: O00194

    1 Blocks protein domain: IPB001806 Transforming protein P21 RAS signature

    UniProtKB/Swiss-Prot: RB27B_HUMAN, O00194
    Similarity: Belongs to the small GTPase superfamily. Rab family


    Find genes that share domains with RAB27B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RB27B_HUMAN, O00194
    Function: May be involved in targeting uroplakins to urothelial apical membranes (By similarity)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity ISS--
    GO:0005515protein binding ----
    GO:0005525GTP binding ISS--
    GO:0019003GDP binding IDA--
    GO:0019904protein domain specific binding IPI16880209
         
    Find genes that share ontologies with RAB27B           About GenesLikeMe


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Rab27b):
     endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism  integument  nervous system 
     no phenotypic analysis  normal  pigmentation  reproductive system  respiratory system 

    Find genes that share phenotypes with RAB27B           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Rab27btm1.2Seab for RAB27B

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RAB27B
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    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate RAB27B (see all 53):
    hsa-miR-640 hsa-miR-30d hsa-miR-3074-3p hsa-miR-578 hsa-miR-759 hsa-miR-29b-1* hsa-miR-374a* hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidRAB27B 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RAB27B

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    Addgene plasmids for RAB27B 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RB27B_HUMAN, O00194: Membrane; Lipid-anchor
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    golgi apparatus5
    cytosol3
    lysosome2
    nucleus2
    plasma membrane2
    vacuole2
    cytoskeleton1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005794Golgi apparatus ----
    GO:0005795Golgi stack IDA19966785
    GO:0016020membrane ----
    GO:0016324apical plasma membrane IEA--

    Find genes that share ontologies with RAB27B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RAB27B About    
    See pathways by source

    SuperPathContained pathways About
    1Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions0.36
    2Pancreatic secretion
    Pancreatic secretion
    3Deregulation of Rab and Rab Effector Genes in Bladder Cancer
    Deregulation of Rab and Rab Effector Genes in Bladder Cancer


    Find genes that share SuperPaths with RAB27B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for RAB27B
        Epithelial Tight Junctions

    1 BioSystems Pathway for RAB27B
        Deregulation of Rab and Rab Effector Genes in Bladder Cancer



    1 Kegg Pathway  (Kegg details for RAB27B):
        Pancreatic secretion

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RAB27B
    Interactions:

        GeneGlobe Interaction Network for RAB27B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for RAB27B (O001943 ENSP000002620944) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MLPHQ9BV363, ENSP000002646054I2D: score=3 STRING: ENSP00000264605
    RPH3ALQ9UNE23, ENSP000003192104I2D: score=3 STRING: ENSP00000319210
    SYTL4Q96C243, ENSP000002630334I2D: score=2 STRING: ENSP00000263033
    SYTL2Q9HCH53, ENSP000003465764I2D: score=1 STRING: ENSP00000346576
    UNC13DQ70J993, ENSP000002075494I2D: score=1 STRING: ENSP00000207549
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process ----
    GO:0006886intracellular protein transport ----
    GO:0006913nucleocytoplasmic transport ----
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction IEA--

    Find genes that share ontologies with RAB27B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RAB27B (RB27B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RAB27B gene: 
    NM_004163.4  

    Unigene Cluster for RAB27B:

    RAB27B, member RAS oncogene family
    Hs.25318  [show with all ESTs]
    Unigene Representative Sequence: NM_004163
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000586570 ENST00000262094(uc002lfr.3) ENST00000586594 ENST00000592334

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    hsa-miR-640 hsa-miR-30d hsa-miR-3074-3p hsa-miR-578 hsa-miR-759 hsa-miR-29b-1* hsa-miR-374a* hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidRAB27B 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF131784.1 AF329499.1 AF498954.1 AK314115.1 BC027474.1 U57093.2 

    6 DOTS entries:

    DT.40110267  DT.307484  DT.97816796  DT.121084137  DT.91695544  DT.97837249 

    Selected AceView cDNA sequences (see all 59):

    AI277199 CB565911 AL707788 BF002851 AF329499 AF498954 BX281002 BU618369 
    NM_004163 BC027474 BX952196 BM787186 AA812916 BF939349 BG284004 AI732288 
    AW592937 CA335387 AW340618 AW664866 BU752963 BM725116 BQ723291 BU742011 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for RAB27B    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
    SP1:                                    
    SP2:                    -               


    ECgene alternative splicing isoforms for RAB27B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RAB27B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACAAATAGG
    RAB27B Expression
    About this image


    RAB27B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Renal Collecting Duct System
     
     Lung (Respiratory System)
             Alveolar type II cells
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Blood (Cardiovascular System)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
     
     Eye (Sensory Organs)
             Conjunctival Epithelium
    RAB27B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RAB27B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.25318

    UniProtKB/Swiss-Prot: RB27B_HUMAN, O00194
    Tissue specificity: Expressed primarily in testis

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB27B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RAB27B gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rab27b1 , 5 RAB27b, member RAS oncogene family1, 5 88.99(n)1
    94.5(a)1
      18 (43.89 cM)5
    807181  NM_030554.31  NP_085031.31 
     699791315 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    34(a)
    many ↔ many
    5(15075853-15081223)
    lizard
    (Anolis carolinensis)
    Reptilia RAB27B6
    RAB27B, member RAS oncogene family
    89(a)
    1 ↔ 1
    GL343213.1(321304-330825)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.163002 Xenopus laevis transcribed sequence with moderate similarity more 81.79(n)    CA982597.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch1073-112i17.11 si:ch1073-112i17.1 72.04(n)
    83.41(a)
      561717  XM_680769.5  XP_685861.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta EG:80H7.43 GTP binding 60(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea 4R79.23 Ras family 42(a)   IV(17480552-17483486)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YPT106
    YPT526
    Rab family GTP-binding protein that contains the P...
    Rab family GTPase, similar to Ypt51p and Ypt53p an...
    31(a)
    25(a)
    many ↔ many
    many ↔ many
    II(737770-738369) YBR264C
    XI(465367-466071) YKR014C


    ENSEMBL Gene Tree for RAB27B (if available)
    TreeFam Gene Tree for RAB27B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RAB27B gene
    RAB27A2  RASEF2  RAB442  
    Selected SIMAP similar genes for RAB27B using alignment to 3 protein entries:     RB27B_HUMAN (see all proteins) (see all similar genes):
    RAB27A    RAB3A    RAB8B    RAB3B    RAB7L1    RAB3D
    RAB37    RAB35    RAB15    RAB26    RAB3C    RAB8A
    RAB11A    RAB7A    RAB17    RRAS2    RAB4B    RAB11B

    Find genes that share paralogs with RAB27B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RAB27B (see all 1490)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1495319151,2
    --52493750(+) AACCTC/TGGAGA 1 -- us2k10--------
    rs1462141921,2
    --52493793(+) GCTATA/CCCTGC 1 -- us2k10--------
    rs1929357201,2
    --52493803(+) CAAGAA/GTTGGC 1 -- us2k10--------
    rs1388245071,2
    --52493990(+) TTGAAC/TTTCAT 1 -- us2k10--------
    rs1848379501,2
    --52494017(+) ACTGCA/GACTTT 1 -- us2k10--------
    rs1897141371,2
    --52494066(+) AAATAC/TAATAG 1 -- us2k10--------
    rs1808768271,2
    --52494073(+) ATAGAC/TGCCTT 1 -- us2k10--------
    rs1126148431,2
    C,F--52494093(+) ACAGTG/AATGTT 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1474726891,2
    --52494121(+) TGAAAC/TTCTAT 1 -- us2k10--------
    rs1839478981,2
    --52494145(+) TAATAA/GCTATT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RAB27B (52385091 - 52562747 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for RAB27B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2660892CNV Deletion23128226
    esv2717130CNV Deletion23290073
    nsv510458CNV Loss20534489
    nsv520160CNV Loss19592680
    nsv2314CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603869    OMIM disorders: --

    3 diseases for RAB27B:    
    About MalaCards
    griscelli syndrome    birt-hogg-dube syndrome    platelet storage pool deficiency

    2 diseases from the University of Copenhagen DISEASES database for RAB27B:
    Birt-Hogg-Dube syndrome     Platelet storage pool deficiency

    Find genes that share disorders with RAB27B           About GenesLikeMe

    Genetic Association Database (GAD): RAB27B
    Human Genome Epidemiology (HuGE) Navigator: RAB27B (2 documents)

    Export disorders for RAB27B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RAB27B gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with RAB27B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of rab27a and rab27b, novel human rab proteins shared by melanocytes and platelets. (PubMed id 9066979)1, 2, 3, 9 Chen D.... Gahl W.A. (Biochem. Mol. Med. 1997)
    2. Chromosomal mapping, gene structure and characterization of the human and murine RAB27B gene. (PubMed id 11178108)1, 2, 9 Ramalho J.S.... Seabra M.C. (BMC Genet. 2001)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Purification, identification, and characterization of two GTP-binding proteins with molecular weights of 25,000 and 21,000 in human platelet cytosol. One is the rap1/smg21/Krev-1 protein and the other is a novel GTP-binding protein. (PubMed id 2507536)1, 2 Nagata K....Nozawa Y. (J. Biol. Chem. 1989)
    6. Intramanchette transport during primate spermiogenesis: expression of dynein, myosin Va, motor recruiter myosin Va, VIIa-Rab27a/b interacting protein, and Rab27b in the manchette during human and monkey spermiogenesis. (PubMed id 18478159)1, 9 Hayasaka S....Okamura K. (Asian J. Androl. 2008)
    7. Vacuolar H+ ATPase expression and activity is required for Rab27B-dependent invasive growth and metastasis of breast cancer. (PubMed id 23390068)1 Hendrix A....De Wever O. (Int. J. Cancer 2013)
    8. Rab27b regulates c-kit expression by controlling the secretion of stem cell factor. (PubMed id 22349512)1 Tanaka C....Tohyama Y. (Biochem. Biophys. Res. Commun. 2012)
    9. Overexpression of the secretory small GTPase Rab27B in human breast cancer correlates closely with lymph node metastasis and predicts poor prognosis. (PubMed id 23217148)1 Zhang J.X....Mai S.J. (J Transl Med 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 5874 HGNC: 9767 AceView: RAB27B Ensembl:ENSG00000041353 euGenes: HUgn5874
    ECgene: RAB27B Kegg: 5874 H-InvDB: RAB27B

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RAB27B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAB27B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for RAB27B gene:
    Search GeneIP for patents involving RAB27B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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