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Aliases for RAB27B Gene

Aliases for RAB27B Gene

  • RAB27B, Member RAS Oncogene Family 2 3 5
  • C25KG 3 4

External Ids for RAB27B Gene

Previous GeneCards Identifiers for RAB27B Gene

  • GC18P052584
  • GC18P052398
  • GC18P052280
  • GC18P050644
  • GC18P050646
  • GC18P052495
  • GC18P049204
  • GC18P052385

Summaries for RAB27B Gene

Entrez Gene Summary for RAB27B Gene

  • Members of the Rab protein family, including RAB27B, are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking (Chen et al., 1997 [PubMed 9066979]).[supplied by OMIM, Nov 2010]

GeneCards Summary for RAB27B Gene

RAB27B (RAB27B, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB27B include Griscelli Syndrome. Among its related pathways are Pancreatic secretion and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include GTP binding and protein domain specific binding. An important paralog of this gene is RAB37.

UniProtKB/Swiss-Prot for RAB27B Gene

  • May be involved in targeting uroplakins to urothelial apical membranes.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB27B Gene

Genomics for RAB27B Gene

Regulatory Elements for RAB27B Gene

Enhancers for RAB27B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RAB27B on UCSC Golden Path with GeneCards custom track

Promoters for RAB27B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RAB27B on UCSC Golden Path with GeneCards custom track

Genomic Location for RAB27B Gene

54,717,860 bp from pter
54,895,516 bp from pter
177,657 bases
Plus strand

Genomic View for RAB27B Gene

Genes around RAB27B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB27B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB27B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB27B Gene

Proteins for RAB27B Gene

  • Protein details for RAB27B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras-related protein Rab-27B
    Protein Accession:
    Secondary Accessions:
    • B2RAB0
    • Q9BZB6

    Protein attributes for RAB27B Gene

    218 amino acids
    Molecular mass:
    24608 Da
    Quaternary structure:
    • Interacts with SYTL2, SYTL4, MYRIP and MLPH. Interacts with RPH3A and RPH3A (By similarity).

    Three dimensional structures from OCA and Proteopedia for RAB27B Gene

neXtProt entry for RAB27B Gene

Proteomics data for RAB27B Gene at MOPED

Post-translational modifications for RAB27B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB27B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RAB27B Gene

Domains & Families for RAB27B Gene

Gene Families for RAB27B Gene

Suggested Antigen Peptide Sequences for RAB27B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Rab family.
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB27B: view

Function for RAB27B Gene

Molecular function for RAB27B Gene

UniProtKB/Swiss-Prot Function:
May be involved in targeting uroplakins to urothelial apical membranes.
genes like me logo Genes that share phenotypes with RAB27B: view

Animal Models for RAB27B Gene

MGI Knock Outs for RAB27B:

Animal Model Products

miRNA for RAB27B Gene

miRTarBase miRNAs that target RAB27B

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RAB27B Gene

Localization for RAB27B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB27B Gene

Membrane; Lipid-anchor.

Subcellular locations from

Jensen Localization Image for RAB27B Gene COMPARTMENTS Subcellular localization image for RAB27B gene
Compartment Confidence
endosome 5
extracellular 5
golgi apparatus 5
cytosol 4
plasma membrane 4
lysosome 2
nucleus 2
vacuole 2
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RAB27B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005795 Golgi stack IDA 19966785
GO:0030140 trans-Golgi network transport vesicle IDA 19966785
GO:0042470 melanosome IDA 15357836
genes like me logo Genes that share ontologies with RAB27B: view

Pathways & Interactions for RAB27B Gene

genes like me logo Genes that share pathways with RAB27B: view

Pathways by source for RAB27B Gene

1 KEGG pathway for RAB27B Gene
1 Qiagen pathway for RAB27B Gene

Gene Ontology (GO) - Biological Process for RAB27B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045921 positive regulation of exocytosis IMP 19966785
GO:0071985 multivesicular body sorting pathway IMP 19966785
genes like me logo Genes that share ontologies with RAB27B: view

No data available for SIGNOR curated interactions for RAB27B Gene

Drugs & Compounds for RAB27B Gene

No Compound Related Data Available

Transcripts for RAB27B Gene

Unigene Clusters for RAB27B Gene

RAB27B, member RAS oncogene family:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAB27B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP2: -

Relevant External Links for RAB27B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RAB27B Gene

mRNA expression in normal human tissues for RAB27B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB27B Gene

This gene is overexpressed in Esophagus - Mucosa (x5.2) and Brain - Anterior cingulate cortex (BA24) (x4.1).

Protein differential expression in normal tissues from HIPED for RAB27B Gene

This gene is overexpressed in Platelet (41.3) and Monocytes (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB27B Gene

SOURCE GeneReport for Unigene cluster for RAB27B Gene Hs.25318

mRNA Expression by UniProt/SwissProt for RAB27B Gene

Tissue specificity: Expressed primarily in testis.
genes like me logo Genes that share expression patterns with RAB27B: view

Primer Products

No data available for Protein tissue co-expression partners for RAB27B Gene

Orthologs for RAB27B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAB27B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RAB27B 35
  • 90.52 (n)
  • 93.58 (a)
RAB27B 36
  • 94 (a)
(Canis familiaris)
Mammalia RAB27B 35
  • 91.59 (n)
  • 96.79 (a)
RAB27B 36
  • 97 (a)
(Mus musculus)
Mammalia Rab27b 35
  • 88.99 (n)
  • 94.5 (a)
Rab27b 16
Rab27b 36
  • 94 (a)
(Pan troglodytes)
Mammalia RAB27B 35
  • 99.85 (n)
  • 99.54 (a)
RAB27B 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rab27b 35
  • 88.07 (n)
  • 93.58 (a)
(Monodelphis domestica)
Mammalia RAB27B 36
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia RAB27B 36
  • 93 (a)
(Gallus gallus)
Aves -- 36
  • 34 (a)
(Anolis carolinensis)
Reptilia RAB27B 36
  • 89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rab27b 35
  • 78.9 (n)
  • 88.53 (a)
Str.6764 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.16300 35
(Danio rerio)
Actinopterygii si:ch1073-112i17.1 35
  • 72.04 (n)
  • 83.41 (a)
RAB27B 36
  • 80 (a)
fruit fly
(Drosophila melanogaster)
Insecta EG:80H7.4 37
  • 60 (a)
Rab27 36
  • 47 (a)
(Caenorhabditis elegans)
Secernentea 4R79.2 37
  • 42 (a)
aex-6 36
  • 61 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPT10 36
  • 31 (a)
YPT52 36
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 61 (a)
Species with no ortholog for RAB27B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB27B Gene

Gene Tree for RAB27B (if available)
Gene Tree for RAB27B (if available)

Paralogs for RAB27B Gene

genes like me logo Genes that share paralogs with RAB27B: view

Variants for RAB27B Gene

Sequence variations from dbSNP and Humsavar for RAB27B Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs9966265 - 54,884,367(+) GAGAC(A/G/T)CCATG nc-transcript-variant, reference, missense
rs4638672 -- 54,876,098(+) TGAAG(A/G)GAAAG intron-variant
rs7231263 -- 54,825,936(+) GCTTT(A/T)TACCA intron-variant
rs7231363 -- 54,880,525(+) TTAGC(A/G)AGTGT intron-variant
rs7231858 -- 54,880,844(+) GGCAG(C/G/T)CTTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB27B Gene

Variant ID Type Subtype PubMed ID
nsv510458 CNV Loss 20534489
esv2660892 CNV Deletion 23128226
nsv520160 CNV Loss 19592680
nsv2314 CNV Loss 18451855
esv2717130 CNV Deletion 23290073

Variation tolerance for RAB27B Gene

Residual Variation Intolerance Score: 66.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.03; 21.13% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RAB27B Gene

Disorders for RAB27B Gene

MalaCards: The human disease database

(1) MalaCards diseases for RAB27B Gene - From: GeneCards

Disorder Aliases PubMed IDs
griscelli syndrome
  • gs
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for RAB27B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RAB27B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RAB27B Gene

Publications for RAB27B Gene

  1. Molecular cloning and characterization of rab27a and rab27b, novel human rab proteins shared by melanocytes and platelets. (PMID: 9066979) Chen D. … Gahl W.A. (Biochem. Mol. Med. 1997) 2 3 4 23 67
  2. Intramanchette transport during primate spermiogenesis: expression of dynein, myosin Va, motor recruiter myosin Va, VIIa-Rab27a/b interacting protein, and Rab27b in the manchette during human and monkey spermiogenesis. (PMID: 18478159) Hayasaka S. … Okamura K. (Asian J. Androl. 2008) 3 23
  3. Rab27b is up-regulated in human Griscelli syndrome type II melanocytes and linked to the actin cytoskeleton via exon F-Myosin Va transcripts. (PMID: 15357836) Westbroek W. … Naeyaert J.M. (Pigment Cell Res. 2004) 3 23
  4. Chromosomal mapping, gene structure and characterization of the human and murine RAB27B gene. (PMID: 11178108) Ramalho J.S. … Seabra M.C. (BMC Genet. 2001) 3 23
  5. Rab7a and Rab27b control secretion of endothelial microRNA through extracellular vesicles. (PMID: 26348397) JaAc N. … Dimmeler S. (FEBS Lett. 2015) 3

Products for RAB27B Gene

Sources for RAB27B Gene