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Aliases for RAB27B Gene

Aliases for RAB27B Gene

  • RAB27B, Member RAS Oncogene Family 2 3 5
  • C25KG 3 4
  • Ras-Related Protein Rab-27B 3

External Ids for RAB27B Gene

Previous GeneCards Identifiers for RAB27B Gene

  • GC18P052584
  • GC18P052398
  • GC18P052280
  • GC18P050644
  • GC18P050646
  • GC18P052495
  • GC18P049204
  • GC18P052385

Summaries for RAB27B Gene

Entrez Gene Summary for RAB27B Gene

  • Members of the Rab protein family, including RAB27B, are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking (Chen et al., 1997 [PubMed 9066979]).[supplied by OMIM, Nov 2010]

GeneCards Summary for RAB27B Gene

RAB27B (RAB27B, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include GTP binding and protein domain specific binding. An important paralog of this gene is RAB27A.

UniProtKB/Swiss-Prot for RAB27B Gene

  • May be involved in targeting uroplakins to urothelial apical membranes.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB27B Gene

Genomics for RAB27B Gene

Regulatory Elements for RAB27B Gene

Enhancers for RAB27B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18F054822 1.1 FANTOM5 ENCODE 19.6 +105.4 105396 1.2 GTF2F1 TBP JUN MAX RFX5 SMC3 RCOR1 NR2F6 CHD2 TCF7L2 RAB27B POLI ENSG00000267311 GC18P054745
GH18F054879 0.9 Ensembl ENCODE 11.2 +163.0 162951 1.9 RFX1 TAL1 JUN MAFG ARID1B ZNF316 MAFF NCOR1 KDM1A MAFK RAB27B CCDC68 ENSG00000267311 ENSG00000267112
GH18F054873 0.7 ENCODE 12.1 +155.9 155911 1.1 SMARCE1 MTA2 TAL1 FEZF1 RAD21 YY1 ARID1B KLF16 GATA2 NCOR1 RAB27B ENSG00000267311 GC18P054745
GH18F054805 1.1 Ensembl ENCODE 5.2 +88.1 88141 1.6 HDAC1 PKNOX1 ATF1 JUN MAX SIN3A RAD21 GATA2 NCOR1 TRIM24 RAB27B POLI GC18P054745 ENSG00000267311
GH18F054852 0.2 Ensembl 12.2 +135.0 135042 0.6 RAB27B CCDC68 ENSG00000267311 GC18P054745
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RAB27B on UCSC Golden Path with GeneCards custom track

Promoters for RAB27B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001813540 240 601 ZNF143

Genomic Location for RAB27B Gene

54,717,860 bp from pter
54,895,516 bp from pter
177,657 bases
Plus strand

Genomic View for RAB27B Gene

Genes around RAB27B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB27B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB27B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB27B Gene

Proteins for RAB27B Gene

  • Protein details for RAB27B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras-related protein Rab-27B
    Protein Accession:
    Secondary Accessions:
    • B2RAB0
    • Q9BZB6

    Protein attributes for RAB27B Gene

    218 amino acids
    Molecular mass:
    24608 Da
    Quaternary structure:
    • Interacts with SYTL2, SYTL4, MYRIP and MLPH. Interacts with RPH3A and RPH3A (By similarity).

    Three dimensional structures from OCA and Proteopedia for RAB27B Gene

neXtProt entry for RAB27B Gene

Post-translational modifications for RAB27B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB27B Gene

No data available for DME Specific Peptides for RAB27B Gene

Domains & Families for RAB27B Gene

Gene Families for RAB27B Gene

Protein Domains for RAB27B Gene

Suggested Antigen Peptide Sequences for RAB27B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Rab family.
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB27B: view

Function for RAB27B Gene

Molecular function for RAB27B Gene

UniProtKB/Swiss-Prot Function:
May be involved in targeting uroplakins to urothelial apical membranes.

Gene Ontology (GO) - Molecular Function for RAB27B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity ISS --
GO:0005515 protein binding IPI 15357836
GO:0005525 GTP binding IEA,ISS --
GO:0019003 GDP binding IDA 20937701
GO:0019904 protein domain specific binding IPI 16880209
genes like me logo Genes that share ontologies with RAB27B: view
genes like me logo Genes that share phenotypes with RAB27B: view

Animal Models for RAB27B Gene

MGI Knock Outs for RAB27B:

Animal Model Products

miRNA for RAB27B Gene

miRTarBase miRNAs that target RAB27B

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RAB27B Gene

Localization for RAB27B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB27B Gene

Membrane; Lipid-anchor.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB27B gene
Compartment Confidence
plasma membrane 5
extracellular 5
golgi apparatus 5
endosome 5
cytosol 4
nucleus 2
lysosome 2
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RAB27B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005795 Golgi stack IDA 19966785
GO:0016020 membrane IEA --
GO:0016324 apical plasma membrane IEA --
genes like me logo Genes that share ontologies with RAB27B: view

Pathways & Interactions for RAB27B Gene

genes like me logo Genes that share pathways with RAB27B: view

Pathways by source for RAB27B Gene

Gene Ontology (GO) - Biological Process for RAB27B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0017157 regulation of exocytosis IEA --
GO:0032402 melanosome transport IBA --
GO:0045921 positive regulation of exocytosis IMP 19966785
GO:0071985 multivesicular body sorting pathway IMP 19966785
genes like me logo Genes that share ontologies with RAB27B: view

No data available for SIGNOR curated interactions for RAB27B Gene

Transcripts for RAB27B Gene

Unigene Clusters for RAB27B Gene

RAB27B, member RAS oncogene family:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB27B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP2: -

Relevant External Links for RAB27B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RAB27B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RAB27B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB27B Gene

This gene is overexpressed in Esophagus - Mucosa (x5.2) and Brain - Anterior cingulate cortex (BA24) (x4.1).

Protein differential expression in normal tissues from HIPED for RAB27B Gene

This gene is overexpressed in Platelet (41.3) and Monocytes (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RAB27B Gene

NURSA nuclear receptor signaling pathways regulating expression of RAB27B Gene:


SOURCE GeneReport for Unigene cluster for RAB27B Gene:


mRNA Expression by UniProt/SwissProt for RAB27B Gene:

Tissue specificity: Expressed primarily in testis.
genes like me logo Genes that share expression patterns with RAB27B: view

Primer Products

No data available for Protein tissue co-expression partners for RAB27B Gene

Orthologs for RAB27B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAB27B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RAB27B 34 35
  • 99.85 (n)
(Monodelphis domestica)
Mammalia RAB27B 35
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia RAB27B 35
  • 93 (a)
(Canis familiaris)
Mammalia RAB27B 34 35
  • 91.59 (n)
(Bos Taurus)
Mammalia RAB27B 34 35
  • 90.52 (n)
(Mus musculus)
Mammalia Rab27b 34 16 35
  • 88.99 (n)
(Rattus norvegicus)
Mammalia Rab27b 34
  • 88.07 (n)
(Gallus gallus)
Aves -- 35
  • 34 (a)
(Anolis carolinensis)
Reptilia RAB27B 35
  • 89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rab27b 34
  • 78.9 (n)
Str.6764 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.16300 34
(Danio rerio)
Actinopterygii RAB27B 35
  • 80 (a)
si:ch1073-112i17.1 34
  • 72.04 (n)
fruit fly
(Drosophila melanogaster)
Insecta EG:80H7.4 36
  • 60 (a)
Rab27 35
  • 47 (a)
(Caenorhabditis elegans)
Secernentea aex-6 35
  • 61 (a)
4R79.2 36
  • 42 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPT10 35
  • 31 (a)
YPT52 35
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 61 (a)
Species where no ortholog for RAB27B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB27B Gene

Gene Tree for RAB27B (if available)
Gene Tree for RAB27B (if available)

Paralogs for RAB27B Gene

Variants for RAB27B Gene

Sequence variations from dbSNP and Humsavar for RAB27B Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs10083909 -- 54,781,858(+) ACATT(C/T)TTCTC intron-variant
rs10164130 -- 54,848,132(+) gcaca(A/G)gtgtg intron-variant
rs1035222 -- 54,761,884(+) agtct(C/T)ctaat intron-variant
rs1035223 -- 54,762,511(+) ctctt(G/T)ttcac intron-variant
rs1035224 -- 54,762,919(+) TCAGT(A/G)TGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB27B Gene

Variant ID Type Subtype PubMed ID
nsv520160 CNV loss 19592680
nsv510458 OTHER sequence alteration 20534489
nsv2314 CNV deletion 18451855
esv3642588 CNV loss 21293372
esv2717130 CNV deletion 23290073
esv2660892 CNV deletion 23128226

Variation tolerance for RAB27B Gene

Residual Variation Intolerance Score: 66.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.03; 21.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAB27B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB27B Gene

Disorders for RAB27B Gene

Relevant External Links for RAB27B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RAB27B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB27B Gene

Publications for RAB27B Gene

  1. Molecular cloning and characterization of rab27a and rab27b, novel human rab proteins shared by melanocytes and platelets. (PMID: 9066979) Chen D. … Gahl W.A. (Biochem. Mol. Med. 1997) 2 3 4 22 64
  2. Chromosomal mapping, gene structure and characterization of the human and murine RAB27B gene. (PMID: 11178108) Ramalho J.S. … Seabra M.C. (BMC Genet. 2001) 3 4 22 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Intramanchette transport during primate spermiogenesis: expression of dynein, myosin Va, motor recruiter myosin Va, VIIa-Rab27a/b interacting protein, and Rab27b in the manchette during human and monkey spermiogenesis. (PMID: 18478159) Hayasaka S. … Okamura K. (Asian J. Androl. 2008) 3 22 64
  5. Rab27b is up-regulated in human Griscelli syndrome type II melanocytes and linked to the actin cytoskeleton via exon F-Myosin Va transcripts. (PMID: 15357836) Westbroek W. … Naeyaert J.M. (Pigment Cell Res. 2004) 3 22 64

Products for RAB27B Gene

Sources for RAB27B Gene

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