Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RAB27B Gene

Aliases for RAB27B Gene

  • RAB27B, Member RAS Oncogene Family 2 3
  • C25KG 3 4
  • Ras-Related Protein Rab-27B 3

External Ids for RAB27B Gene

Summaries for RAB27B Gene

Entrez Gene Summary for RAB27B Gene

  • Members of the Rab protein family, including RAB27B, are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking (Chen et al., 1997 [PubMed 9066979]).[supplied by OMIM, Nov 2010]

GeneCards Summary for RAB27B Gene

RAB27B (RAB27B, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB27B include griscelli syndrome and birt-hogg-dube syndrome. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Pancreatic secretion. GO annotations related to this gene include GTP binding and protein domain specific binding. An important paralog of this gene is RAB44.

UniProtKB/Swiss-Prot for RAB27B Gene

  • May be involved in targeting uroplakins to urothelial apical membranes.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB27B Gene

Genomics for RAB27B Gene

Genomic Location for RAB27B Gene

Start:
54,717,860 bp from pter
End:
54,895,516 bp from pter
Size:
177,657 bases
Orientation:
Plus strand

Genomic View for RAB27B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAB27B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB27B Gene

Regulatory Elements for RAB27B Gene

Proteins for RAB27B Gene

  • Protein details for RAB27B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00194-RB27B_HUMAN
    Recommended name:
    Ras-related protein Rab-27B
    Protein Accession:
    O00194
    Secondary Accessions:
    • B2RAB0
    • Q9BZB6

    Protein attributes for RAB27B Gene

    Size:
    218 amino acids
    Molecular mass:
    24608 Da
    Quaternary structure:
    • Interacts with SYTL2, SYTL4, MYRIP and MLPH. Interacts with RPH3A and RPH3A (By similarity).

    Three dimensional structures from OCA and Proteopedia for RAB27B Gene

neXtProt entry for RAB27B Gene

Proteomics data for RAB27B Gene at MOPED

Post-translational modifications for RAB27B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB27B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RAB27B Gene

Domains for RAB27B Gene

Gene Families for RAB27B Gene

HGNC:
  • RAB :RAB, member RAS oncogene

UniProtKB/Swiss-Prot:

RB27B_HUMAN
Family:
  • Belongs to the small GTPase superfamily. Rab family.:
    • O00194
genes like me logo Genes that share domains with RAB27B: view

Function for RAB27B Gene

Molecular function for RAB27B Gene

UniProtKB/Swiss-Prot Function: May be involved in targeting uroplakins to urothelial apical membranes.

Gene Ontology (GO) - Molecular Function for RAB27B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity ISS --
GO:0005515 protein binding IPI 15357836
GO:0005525 GTP binding ISS --
GO:0019003 GDP binding IDA 20937701
GO:0019904 protein domain specific binding IPI 16880209
genes like me logo Genes that share ontologies with RAB27B: view
genes like me logo Genes that share phenotypes with RAB27B: view

Animal Models for RAB27B Gene

MGI Knock Outs for RAB27B:

miRNA for RAB27B Gene

miRTarBase miRNAs that target RAB27B

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for RAB27B Gene

Localization for RAB27B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB27B Gene

Membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB27B Gene COMPARTMENTS Subcellular localization image for RAB27B gene
Compartment Confidence
endosome 5
golgi apparatus 5
cytosol 3
lysosome 2
nucleus 2
plasma membrane 2
vacuole 2
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RAB27B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005794 Golgi apparatus --
GO:0005795 Golgi stack IDA 19966785
GO:0016020 membrane --
GO:0016324 apical plasma membrane IEA --
genes like me logo Genes that share ontologies with RAB27B: view

Pathways for RAB27B Gene

genes like me logo Genes that share pathways with RAB27B: view

Pathways by source for RAB27B Gene

1 Qiagen pathway for RAB27B Gene
1 KEGG pathway for RAB27B Gene

Gene Ontology (GO) - Biological Process for RAB27B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport IBA --
GO:0006904 vesicle docking involved in exocytosis IBA --
GO:0006913 nucleocytoplasmic transport --
GO:0007165 signal transduction --
genes like me logo Genes that share ontologies with RAB27B: view

Transcripts for RAB27B Gene

Unigene Clusters for RAB27B Gene

RAB27B, member RAS oncogene family:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAB27B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1:
SP2: -

Relevant External Links for RAB27B Gene

GeneLoc Exon Structure for
RAB27B
ECgene alternative splicing isoforms for
RAB27B

Expression for RAB27B Gene

mRNA expression in normal human tissues for RAB27B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB27B Gene

This gene is overexpressed in Esophagus - Mucosa (5.2) and Brain - Anterior cingulate cortex (BA24) (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB27B Gene

SOURCE GeneReport for Unigene cluster for RAB27B Gene Hs.25318

mRNA Expression by UniProt/SwissProt for RAB27B Gene

O00194-RB27B_HUMAN
Tissue specificity: Expressed primarily in testis
genes like me logo Genes that share expressions with RAB27B: view

Orthologs for RAB27B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAB27B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB27B 36
  • 99.85 (n)
  • 99.54 (a)
RAB27B 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RAB27B 36
  • 90.52 (n)
  • 93.58 (a)
RAB27B 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAB27B 36
  • 91.59 (n)
  • 96.79 (a)
RAB27B 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rab27b 36
  • 88.99 (n)
  • 94.5 (a)
Rab27b 16
Rab27b 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAB27B 37
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAB27B 37
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rab27b 36
  • 88.07 (n)
  • 93.58 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 34 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia RAB27B 37
  • 89 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.16300 36
tropical clawed frog
(Silurana tropicalis)
Amphibia rab27b 36
  • 78.9 (n)
  • 88.53 (a)
Str.6764 36
zebrafish
(Danio rerio)
Actinopterygii RAB27B 37
  • 80 (a)
OneToOne
si:ch1073-112i17.1 36
  • 72.04 (n)
  • 83.41 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rab27 37
  • 47 (a)
OneToMany
EG:80H7.4 38
  • 60 (a)
worm
(Caenorhabditis elegans)
Secernentea aex-6 37
  • 61 (a)
OneToMany
4R79.2 38
  • 42 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPT10 37
  • 31 (a)
ManyToMany
YPT52 37
  • 25 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 61 (a)
OneToMany
Species with no ortholog for RAB27B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB27B Gene

ENSEMBL:
Gene Tree for RAB27B (if available)
TreeFam:
Gene Tree for RAB27B (if available)

Paralogs for RAB27B Gene

Paralogs for RAB27B Gene

genes like me logo Genes that share paralogs with RAB27B: view

Variants for RAB27B Gene

Sequence variations from dbSNP and Humsavar for RAB27B Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs918131 -- 54,756,503(+) CCATA(C/T)TGTTA intron-variant
rs988661 -- 54,882,165(+) CTACA(A/G)ACAAA intron-variant
rs988736 -- 54,738,344(-) aatac(A/C)tgggg intron-variant
rs1035222 -- 54,761,884(+) agtct(C/T)ctaat intron-variant
rs1035223 -- 54,762,511(+) ctctt(G/T)ttcac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB27B Gene

Variant ID Type Subtype PubMed ID
nsv510458 CNV Loss 20534489
esv2660892 CNV Deletion 23128226
nsv520160 CNV Loss 19592680
nsv2314 CNV Loss 18451855
esv2717130 CNV Deletion 23290073

Relevant External Links for RAB27B Gene

HapMap Linkage Disequilibrium report
RAB27B

Disorders for RAB27B Gene

(2) University of Copenhagen DISEASES for RAB27B Gene

Relevant External Links for RAB27B

Genetic Association Database (GAD)
RAB27B
Human Genome Epidemiology (HuGE) Navigator
RAB27B
genes like me logo Genes that share disorders with RAB27B: view

No data available for UniProtKB/Swiss-Prot for RAB27B Gene

Publications for RAB27B Gene

  1. Molecular cloning and characterization of rab27a and rab27b, novel human rab proteins shared by melanocytes and platelets. (PMID: 9066979) Chen D. … Gahl W.A. (Biochem. Mol. Med. 1997) 2 3 4 23
  2. Chromosomal mapping, gene structure and characterization of the human and murine RAB27B gene. (PMID: 11178108) Ramalho J.S. … Seabra M.C. (BMC Genet. 2001) 3 4 23
  3. Purification, identification, and characterization of two GTP-binding proteins with molecular weights of 25,000 and 21,000 in human platelet cytosol. One is the rap1/smg21/Krev-1 protein and the other is a novel GTP-binding protein. (PMID: 2507536) Nagata K. … Nozawa Y. (J. Biol. Chem. 1989) 3 4
  4. Rab27b is up-regulated in human Griscelli syndrome type II melanocytes and linked to the actin cytoskeleton via exon F-Myosin Va transcripts. (PMID: 15357836) Westbroek W. … Naeyaert J.M. (Pigment Cell Res. 2004) 3 23
  5. Intramanchette transport during primate spermiogenesis: expression of dynein, myosin Va, motor recruiter myosin Va, VIIa-Rab27a/b interacting protein, and Rab27b in the manchette during human and monkey spermiogenesis. (PMID: 18478159) Hayasaka S. … Okamura K. (Asian J. Androl. 2008) 3 23

Products for RAB27B Gene

Sources for RAB27B Gene

Back to Top

Content