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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RAB27B Gene

protein-coding   GIFtS: 62
GCID: GC18P052385

RAB27B, Member RAS Oncogene Family

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
RAB27B, Member RAS Oncogene Family1 2
C25KG2 3
Ras-Related Protein Rab-27B2

External Ids:    HGNC: 97671   Entrez Gene: 58742   Ensembl: ENSG000000413537   OMIM: 6038695   UniProtKB: O001943   

Export aliases for RAB27B gene to outside databases

Previous GC identifers: GC18P052584 GC18P052398 GC18P052280 GC18P050644 GC18P050646 GC18P052495 GC18P049204


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RAB27B Gene:
Members of the Rab protein family, including RAB27B, are prenylated, membrane-bound proteins involved in vesicular
fusion and trafficking (Chen et al., 1997 (PubMed 9066979)).(supplied by OMIM, Nov 2010)

GeneCards Summary for RAB27B Gene: 
RAB27B (RAB27B, member RAS oncogene family) is a protein-coding gene. Diseases associated with RAB27B include birt-hogg-dube syndrome, and griscelli syndrome, and among its related super-pathways are Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include GTP binding and protein domain specific binding. An important paralog of this gene is RAB10.

UniProtKB/Swiss-Prot: RB27B_HUMAN, O00194
Function: May be involved in targeting uroplakins to urothelial apical membranes (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NT_025028.14  NC_018929.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RAB27B gene promoter:
         Oct-B1   oct-B3   oct-B2   p53   POU6F1 (c2)   Ik-3   Gfi-1   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRAB27B promoter sequence
   Search SABiosciences Chromatin IP Primers for RAB27B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB27B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.2   Ensembl cytogenetic band:  18q21.2   HGNC cytogenetic band: 18q21.2

RAB27B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAB27B gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P052385:  view genomic region     (about GC identifiers)

Start:
52,385,091 bp from pter      End:
52,562,747 bp from pter
Size:
177,657 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RB27B_HUMAN, O00194 (See protein sequence)
Recommended Name: Ras-related protein Rab-27B  
Size: 218 amino acids; 24608 Da
Subunit: Interacts with SYTL2, SYTL4, MYRIP and MLPH. Interacts with RPH3A and RPH3A (By similarity)
Subcellular location: Membrane; Lipid-anchor
1 PDB 3D structure from and Proteopedia for RAB27B:
2F7S (3D)    
Secondary accessions: B2RAB0 Q9BZB6

Explore the universe of human proteins at neXtProt for RAB27B: NX_O00194

Explore proteomics data for RAB27B at MOPED 

RAB27B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

RAB27B Protein Expression

REFSEQ proteins: NP_004154.2  
ENSEMBL proteins: 
 ENSP00000468542   ENSP00000262094   ENSP00000465009  

Human Recombinant Protein Products for RAB27B: 
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Novus Biologicals RAB27B Lysates
Sino Biological Recombinant Protein for RAB27B
Sino Biological Cell Lysate for RAB27B 
ProSpec Recombinant Protein for RAB27B
Cloud-Clone Corp. Proteins for RAB27B 

Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005622intracellular ----
GO:0005794Golgi apparatus ----
GO:0005795Golgi stack IDA19966785
GO:0016020membrane ----
GO:0016324apical plasma membrane IEA--

RAB27B for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
RAB: RAB, member RAS oncogene

4 InterPro protein domains:
 IPR005225 Small_GTP-bd_dom
 IPR001806 Small_GTPase
 IPR003579 Small_GTPase_Rab_type
 IPR027417 P-loop_NTPase

Graphical View of Domain Structure for InterPro Entry O00194

ProtoNet protein and cluster: O00194

1 Blocks protein domain: IPB001806 Transforming protein P21 RAS signature

UniProtKB/Swiss-Prot: RB27B_HUMAN, O00194
Similarity: Belongs to the small GTPase superfamily. Rab family


RAB27B for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: RB27B_HUMAN, O00194
Function: May be involved in targeting uroplakins to urothelial apical membranes (By similarity)

     Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003924GTPase activity ISS--
GO:0005515protein binding ----
GO:0005525GTP binding ISS--
GO:0019003GDP binding IDA--
GO:0019904protein domain specific binding IPI16880209
     
RAB27B for ontologies           About GeneDecksing


Phenotypes:
     9 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Rab27b):
 endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism  integument  nervous system 
 no phenotypic analysis  normal  pigmentation  reproductive system 

RAB27B for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Rab27btm1.2Seab for RAB27B

   inGenious Targeting Laboratory - Custom generated mouse model solutions for RAB27B 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RAB27B

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RAB27B 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RAB27B 

miRNA
Products:
    
miRTarBase miRNAs that target RAB27B:
hsa-mir-30a (MIRT005197), hsa-mir-155 (MIRT001512)

QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAB27B
8/53 QIAGEN miScript miRNA Assays for microRNAs that regulate RAB27B (see all 53):
hsa-miR-640 hsa-miR-30d hsa-miR-3074-3p hsa-miR-578 hsa-miR-759 hsa-miR-29b-1* hsa-miR-374a* hsa-miR-9
SwitchGear 3'UTR luciferase reporter plasmidRAB27B 3' UTR sequence
Inhib. RNA
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Gene Editing
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB27B


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for RAB27B About                                                                                                See pathways by source

SuperPathContained pathways About
1Sertoli-Sertoli Cell Junction Dynamics
Epithelial Tight Junctions0.36
2Deregulation of Rab and Rab Effector Genes in Bladder Cancer
Deregulation of Rab and Rab Effector Genes in Bladder Cancer
3Pancreatic secretion
Pancreatic secretion

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RAB27B
    Epithelial Tight Junctions

1 BioSystems Pathway for RAB27B
    Deregulation of Rab and Rab Effector Genes in Bladder Cancer



1         Kegg Pathway  (Kegg details for RAB27B):
    Pancreatic secretion


RAB27B for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAB27B

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

5/9 Interacting proteins for RAB27B (O001943 ENSP000002620944) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
InteractantInteraction Details
GeneCardExternal ID(s)
MLPHQ9BV363, ENSP000002646054I2D: score=3 STRING: ENSP00000264605
RPH3ALQ9UNE23, ENSP000003192104I2D: score=3 STRING: ENSP00000319210
SYTL4Q96C243, ENSP000002630334I2D: score=2 STRING: ENSP00000263033
SYTL2Q9HCH53, ENSP000003465764I2D: score=1 STRING: ENSP00000346576
UNC13DQ70J993, ENSP000002075494I2D: score=1 STRING: ENSP00000207549
About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006184GTP catabolic process ----
GO:0006886intracellular protein transport ----
GO:0006913nucleocytoplasmic transport ----
GO:0007165signal transduction ----
GO:0007264small GTPase mediated signal transduction IEA--

RAB27B for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RAB27B (RB27B)

Search CenterWatch for drugs/clinical trials and news about RAB27B / RB27B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RAB27B gene: 
NM_004163.4  

Unigene Cluster for RAB27B:

RAB27B, member RAS oncogene family
Hs.25318  [show with all ESTs]
Unigene Representative Sequence: NM_004163
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000586570 ENST00000262094(uc002lfr.3) ENST00000586594 ENST00000592334

miRNA
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hsa-miR-640 hsa-miR-30d hsa-miR-3074-3p hsa-miR-578 hsa-miR-759 hsa-miR-29b-1* hsa-miR-374a* hsa-miR-9
SwitchGear 3'UTR luciferase reporter plasmidRAB27B 3' UTR sequence
Inhib. RNA
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  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAB27B

Additional mRNA sequence: 

AF131784.1 AF329499.1 AF498954.1 AK314115.1 BC027474.1 U57093.2 

6 DOTS entries:

DT.40110267  DT.307484  DT.97816796  DT.121084137  DT.91695544  DT.97837249 

24/59 AceView cDNA sequences (see all 59):

CB565911 AI277199 AL707788 BF002851 AF329499 AF498954 NM_004163 BU618369 
BC027474 BX281002 AL706527 BF939349 BG284004 CA335387 BU752963 AW340618 
BM725116 BQ723291 BU742011 BQ716712 BM977490 BG195281 BF438386 BG620768 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for RAB27B    About this scheme

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1:                                    
SP2:                    -               


ECgene alternative splicing isoforms for RAB27B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RAB27B expression in normal human tissues (normalized intensities)      RAB27B embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TACAAATAGG
RAB27B Expression
About this image


RAB27B expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/28 selected tissues (see all 28) fully expand
 
 Nose (Sensory Organs)    fully expand to see all 4 entries
         sensory organ/nose/nasal cavity   
 
 Mesenchymal Stem Cells (Muscoskeletal System)    fully expand to see all 4 entries
         Human Mesenchymal Stem Cells (hMSC)-1   
 
 Lower Urinary Tract (Urinary System)    fully expand to see all 3 entries
         urinary bladder ; urothelial cells   
         visceral organ/urethra of male   
 
 Blood (Hematopoietic System)    fully expand to see all 3 entries
         Hematopoietic Stem Cells Hematopoietic Bone Marrow
         platelets   
 
 Brain (Nervous System)    fully expand to see all 3 entries
         Medulla Oblongata
         ganglion/cranial/trigeminal V   

See RAB27B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RAB27B

SOURCE GeneReport for Unigene cluster: Hs.25318

UniProtKB/Swiss-Prot: RB27B_HUMAN, O00194
Tissue specificity: Expressed primarily in testis

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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for RAB27B gene from 6/15 species (see all 15)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Rab27b1 , 5 RAB27b, member RAS oncogene family1, 5 88.99(n)1
94.5(a)1
  18 (43.89 cM)5
807181  NM_001082553.11  NP_001076022.11 
 699791315 
lizard
(Anolis carolinensis)
Reptilia RAB27B6
Uncharacterized protein
89(a)
1 ↔ 1
GL343213.1(321304-330825)
African clawed frog
(Xenopus laevis)
Amphibia Xl.163002 Xenopus laevis transcribed sequence with moderate similarity more 81.79(n)    CA982597.1 
zebrafish
(Danio rerio)
Actinopterygii LOC5617171 ras-related protein Rab-27B-like 72.04(n)
83.41(a)
  561717  XM_680769.4  XP_685861.3 
fruit fly
(Drosophila melanogaster)
Insecta EG:80H7.43 GTP binding 60(a)     --
worm
(Caenorhabditis elegans)
Secernentea 4R79.23 Ras family 42(a)   IV(17480552-17483486)   --


ENSEMBL Gene Tree for RAB27B (if available)
TreeFam Gene Tree for RAB27B (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for RAB27B gene
RAB102  RAB3B2  RAB8A2  RAB3D2  RAB3A2  RAB27A2  RAB8B2  RAB352  
RAB1B2  RAB122  RAB1A2  RAB132  RAB3C2  
18/79 SIMAP similar genes for RAB27B using alignment to 3 protein entries:     RB27B_HUMAN (see all proteins) (see all similar genes):
RAB27A    RAB3A    RAB8B    RAB3B    RAB7L1    RAB3D
RAB37    RAB35    RAB15    RAB26    RAB3C    RAB8A
RAB11A    RAB7A    RAB17    RRAS2    RAB4B    RAB13

RAB27B for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/1490 SNPs in RAB27B are shown (see all 1490)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 18 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1495319151,2
--52493750(+) AACCTC/TGGAGA 1 -- us2k10--------
rs1462141921,2
--52493793(+) GCTATA/CCCTGC 1 -- us2k10--------
rs1929357201,2
--52493803(+) CAAGAA/GTTGGC 1 -- us2k10--------
rs1388245071,2
--52493990(+) TTGAAC/TTTCAT 1 -- us2k10--------
rs1848379501,2
--52494017(+) ACTGCA/GACTTT 1 -- us2k10--------
rs1897141371,2
--52494066(+) AAATAC/TAATAG 1 -- us2k10--------
rs1808768271,2
--52494073(+) ATAGAC/TGCCTT 1 -- us2k10--------
rs1126148431,2
C,F--52494093(+) ACAGTG/AATGTT 1 -- us2k11Minor allele frequency- A:0.50NA 2
rs1474726891,2
--52494121(+) TGAAAC/TTCTAT 1 -- us2k10--------
rs1839478981,2
--52494145(+) TAATAA/GCTATT 1 -- us2k10--------

HapMap Linkage Disequilibrium report for RAB27B (52385091 - 52562747 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for RAB27B:    About this table     
Variant IDTypeSubtypePubMed ID
esv2660892CNV Deletion23128226
esv2717130CNV Deletion23290073
nsv510458CNV Loss20534489
nsv520160CNV Loss19592680
nsv2314CNV Loss18451855

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 603869    OMIM disorders: --

9 diseases for RAB27B:    About MalaCards
birt-hogg-dube syndrome    griscelli syndrome    choroideremia    platelet storage pool deficiency
choroiditis    hepatitis b    hepatitis    pancreatitis
breast cancer

2 diseases from the University of Copenhagen DISEASES database for RAB27B:
Birt-Hogg-Dube syndrome     Platelet storage pool deficiency

RAB27B for disorders           About GeneDecksing

Genetic Association Database (GAD): RAB27B
Human Genome Epidemiology (HuGE) Navigator: RAB27B (2 documents)

Export disorders for RAB27B gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for RAB27B gene, integrated from 9 sources (see all 33):
(articles sorted by number of sources associating them with RAB27B)
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  1. Molecular cloning and characterization of rab27a and rab27b, novel human rab proteins shared by melanocytes and platelets. (PubMed id 9066979)1, 2, 3, 9 Chen D.... Gahl W.A. (1997)
  2. Chromosomal mapping, gene structure and characterization of the human and murine RAB27B gene. (PubMed id 11178108)1, 2, 9 Ramalho J.S.... Seabra M.C. (2001)
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  5. Purification, identification, and characterization of two GTP-binding proteins with molecular weights of 25,000 and 21,000 in human platelet cytosol. One is the rap1/smg21/Krev-1 protein and the other is a novel GTP-binding protein. (PubMed id 2507536)1, 2 Nagata K....Nozawa Y. (1989)
  6. Intramanchette transport during primate spermiogenesis: expression of dynein, myosin Va, motor recruiter myosin Va, VIIa-Rab27a/b interacting protein, and Rab27b in the manchette during human and monkey spermiogenesis. (PubMed id 18478159)1, 9 Hayasaka S....Okamura K. (2008)
  7. Vacuolar H+ ATPase expression and activity is required for Rab27B-dependent invasive growth and metastasis of breast cancer. (PubMed id 23390068)1 Hendrix A....De Wever O. (2013)
  8. Rab27b regulates c-kit expression by controlling the s ecretion of stem cell factor. (PubMed id 22349512)1 Tanaka C....Tohyama Y. (2012)
  9. Overexpression of the secretory small GTPase Rab27B in human breast cancer correlates closely with lymph node metastasis and predicts poor prognosis. (PubMed id 23217148)1 Zhang J.X....Mai S.J. (2012)
  10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5874 HGNC: 9767 AceView: RAB27B Ensembl:ENSG00000041353 euGenes: HUgn5874
ECgene: RAB27B Kegg: 5874 H-InvDB: RAB27B

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for RAB27B Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for RAB27B Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for RAB27B gene:
Search GeneIP for patents involving RAB27B

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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