Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RAB27B Gene

protein-coding   GIFtS: 59
GCID: GC18P052385

RAB27B, member RAS oncogene family
 Explore 11 diseases affiliated with
RAB27B via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RAB27B    

Aliases
for RAB27B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
RAB27B, Member RAS Oncogene Family1 2
C25KG2 3
Ras-Related Protein Rab-27B2

External Ids:    HGNC: 97671   Entrez Gene: 58742   Ensembl: ENSG000000413537   OMIM: 6038695   UniProtKB: O001943   

Export aliases for RAB27B gene to outside databases

Previous GC identifers: GC18P052584 GC18P052398 GC18P052280 GC18P050644 GC18P050646 GC18P052495 GC18P049204


Summaries
for RAB27B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RAB27B:
Members of the Rab protein family, including RAB27B, are prenylated, membrane-bound proteins involved in vesicular
fusion and trafficking (Chen et al., 1997 (PubMed 9066979)).(supplied by OMIM, Nov 2010)

UniProtKB/Swiss-Prot: RB27B_HUMAN, O00194
Function: May be involved in targeting uroplakins to urothelial apical membranes (By similarity)




Genomic Views
for RAB27B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NC_018929.1  NT_025028.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RAB27B gene promoter:
         Oct-B1   oct-B3   oct-B2   p53   POU6F1 (c2)   Ik-3   Gfi-1   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RAB27B promoter sequence
   Search SABiosciences Chromatin IP Primers for RAB27B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB27B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.2   Ensembl cytogenetic band:  18q21.2   HGNC cytogenetic band: 18q21.2

RAB27B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAB27B gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P052385:  view genomic region     (about GC identifiers)

Start:
 52,385,091 bp from pter      End:
 52,562,747 bp from pter
Size:
 177,657 bases      Orientation:
 plus strand

Proteins
for RAB27B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RB27B_HUMAN, O00194 (See protein sequence)
Recommended Name: Ras-related protein Rab-27B  
Size: 218 amino acids; 24608 Da
Subunit: Interacts with SYTL2, SYTL4, MYRIP and MLPH. Interacts with RPH3A and RPH3A (By similarity)
Subcellular location: Membrane; Lipid-anchor
1 PDB 3D structure from and Proteopedia for RAB27B:
2F7S (3D)    
Secondary accessions: B2RAB0 Q9BZB6

Explore the universe of human proteins at neXtProt for RAB27B: NX_O00194

RAB27B Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins: NP_004154.2  
ENSEMBL proteins: 
 ENSP00000468542   ENSP00000262094   ENSP00000465009  

Human Recombinant Protein Products: 
Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein: RAB27B
OriGene Protein Over-expression Lysate: RAB27B
OriGene Custom Protein Services for RAB27B 
GenScript Custom Purified and Recombinant Proteins Services for RAB27B
Novus Biologicals RAB27B Proteins
Novus Biologicals RAB27B Lysates
Browse Sino Biological Recombinant Proteins
ProSpec Recombinant Protein for RAB27B
Uscn Proteins for RAB27B

Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005737cytoplasm ----
GO:0005794Golgi apparatus ----
GO:0005795Golgi stack IDA19966785
GO:0005886plasma membrane ----
GO:0016324apical plasma membrane IEA--


RAB27B for ontologies           About GeneDecksing



RAB27B Antibody Products: 
Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse R&D Systems for Antibodies
Browse OriGene Antibodies
OriGene Custom Antibody Services for RAB27B 
GenScript Custom Superior Antibodies Services for RAB27B
Novus Biologicals RAB27B Antibodies
Search for Antibodies for RAB27B at Abcam  
Uscn Antibodies for RAB27B
ThermoFisher Antibodies for RAB27B

Assay Products for RAB27B: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Immunoassay Development
Browse OriGene Fluorogenic Cell Assay Kits
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for RAB27B
Browse Enzo Life Sciences for kits & assays
Uscn ELISAs and CLIAs for RAB27B

Protein Domains /
Families
for RAB27B gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
RAB27B for domains           About GeneDecksing

3 InterPro domains/families:
 IPR005225 Small_GTP-bd_dom
 IPR001806 Small_GTPase
 IPR003579 Small_GTPase_Rab_type

Graphical View of Domain Structure for InterPro Entry O00194

ProtoNet protein and cluster: O00194

1 Blocks protein family: IPB001806 Transforming protein P21 RAS signature

UniProtKB/Swiss-Prot: RB27B_HUMAN, O00194
Similarity: Belongs to the small GTPase superfamily. Rab family


Function
for RAB27B gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
Function Summary:

     UniProtKB/Swiss-Prot: RB27B_HUMAN, O00194
Function: May be involved in targeting uroplakins to urothelial apical membranes (By similarity)

miRNA
Products:    		miRTarBase miRNAs that target RAB27B:
hsa-mir-30a (MIRT005197), hsa-mir-155 (MIRT001512)

OriGene 3'-UTR Clone: RAB27B
Browse MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAB27B
8/53 QIAGEN miScript miRNA Assays for microRNAs that regulate RAB27B (see all 53):
hsa-miR-640 hsa-miR-30d hsa-miR-3074-3p hsa-miR-578 hsa-miR-759 hsa-miR-29b-1* hsa-miR-374a* hsa-miR-9
SwitchGear 3'UTR luciferase reporter plasmid: RAB27B 3' UTR sequence
Inhib. RNA
Products:    		Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAB27B (see all 7)
OriGene shRNA RFP: RAB27B
OriGene siRNA: RAB27B
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAB27B

Gene Editing
Products:		DNA2.0 Custom Protein Engineering Service for RAB27B

Clone
Products:     		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAB27B (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAB27B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector: RAB27B (NM_004163)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAB27B
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB27B 

Cell Line
Products:     		GenScript Custom overexpressing Cell Line Services for RAB27B
Search LifeMap BioReagents cell lines for RAB27B

In Situ Assay
Products:   
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB27B

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003924GTPase activity ISS--
GO:0005515protein binding ----
GO:0005525GTP binding ISS--
GO:0019003GDP binding IDA--
GO:0019904protein domain specific binding IPI16880209


RAB27B for ontologies           About GeneDecksing


Animal Models:
     Mouse knock-out Rab27btm1.2Seab for RAB27B
     9 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Rab27b):
 endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism  integument  nervous system 
 no phenotypic analysis  normal  pigmentation  reproductive system 

RAB27B for phenotypes           About GeneDecksing


Pathways & Interactions
for RAB27B gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways  About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1Deregulation of Rab and Rab Effector Genes in Bladder Cancer
Deregulation of Rab and Rab Effector Genes in Bladder Cancer1.00
2Pancreatic secretion
Pancreatic secretion1.00
3Sertoli-Sertoli Cell Junction Dynamics
Epithelial Tight Junctions0.36

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RAB27B
    Epithelial Tight Junctions

1 BioSystems Pathway for RAB27B 
    Deregulation of Rab and Rab Effector Genes in Bladder Cancer


1         Kegg Pathway  (Kegg details for RAB27B):
    Pancreatic secretion


RAB27B for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAB27B

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

5/9 Interacting proteins for RAB27B (O001943 ENSP000002620944) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
InteractantInteraction Details
GeneCardExternal ID(s)
MLPHQ9BV363, ENSP000002646054I2D: score=3 STRING: ENSP00000264605
RPH3ALQ9UNE23, ENSP000003192104I2D: score=3 STRING: ENSP00000319210
SYTL4Q96C243, ENSP000002630334I2D: score=2 STRING: ENSP00000263033
SYTL2Q9HCH53, ENSP000003465764I2D: score=1 STRING: ENSP00000346576
UNC13DQ70J993, ENSP000002075494I2D: score=1 STRING: ENSP00000207549
About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006184GTP catabolic process ----
GO:0007264small GTPase mediated signal transduction IEA--
GO:0015031protein transport IEA--
GO:0017157regulation of exocytosis ----
GO:0045921positive regulation of exocytosis IMP19966785


RAB27B for ontologies           About GeneDecksing



Drugs & Compounds
for RAB27B gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RAB27B
Search CenterWatch for drugs/clinical trials and news about RAB27B / RB27B 

Transcripts
for RAB27B gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
REFSEQ mRNAs for RAB27B gene: 
NM_004163.4  

Unigene Cluster for RAB27B:

RAB27B, member RAS oncogene family
Hs.25318  [show with all ESTs]
Unigene Representative Sequence: NM_004163
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000586570 ENST00000262094(uc002lfr.3) ENST00000586594 ENST00000592334


miRNA
Products:     		 OriGene 3'-UTR Clone: RAB27B
Browse OriGene MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAB27B
8/53 QIAGEN miScript miRNA Assays for microRNAs that regulate RAB27B (see all 53):
hsa-miR-640 hsa-miR-30d hsa-miR-3074-3p hsa-miR-578 hsa-miR-759 hsa-miR-29b-1* hsa-miR-374a* hsa-miR-9
SwitchGear 3'UTR luciferase reporter plasmid: RAB27B 3' UTR sequence
Inhib. RNA
Products:     		Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAB27B (see all 7)
OriGene shRNA RFP: RAB27B
OriGene siRNA: RAB27B
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAB27B
Clone
Products:     		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAB27B (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAB27B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector: RAB27B (NM_004163)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAB27B
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB27B 
Primer
Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAB27B
Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RAB27B
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAB27B
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAB27B

Additional cDNA sequence: 

AF131784.1 AF329499.1 AF498954.1 AK314115.1 BC027474.1 U57093.2 

6 DOTS entries:

DT.40110267  DT.307484  DT.97816796  DT.121084137  DT.91695544  DT.97837249 

24/59 AceView cDNA sequences (see all 59):

BX281002 NM_004163 AF498954 AL707788 BF002851 AF329499 BU618369 CB565911 
AI277199 BC027474 BM725116 AW664866 AW340618 BQ723291 BU752963 AW468475 
AF131784 U57093 AA846320 BX952196 BQ020683 AA812916 AI732288 BG284004 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for RAB27B    About this scheme

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1:                                    
SP2:                    -               


ECgene alternative splicing isoforms for RAB27B

Expression
for RAB27B gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RAB27B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACAAATAGG

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)
About this image

RAB27B expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
3 LifeMap In Vivo Development Anatomical Compartments/Cells 
Tissue Anatomical Compartment CellCategory (developmental path)
Yolk SacDefinitive Yolk SacDefinitive Hematopoietic Stem CellsBlood
BrainMedulla OblongataBrain
KidneyRenal Collecting Duct SystemKidney
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 5 LifeMap Cells 
NameCategory
PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)Heart, Myocardium, Smooth Muscle
PureStem™ progenitor EN13 (Embryonic Progenitor Cell)
PureStem™ progenitor EN7 (Embryonic Progenitor Cell)
PureStem™ progenitor F15 (Embryonic Progenitor Cell)
PureStem™ progenitor W10 (Embryonic Progenitor Cell)

See RAB27B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RAB27B

SOURCE GeneReport for Unigene cluster: Hs.25318

UniProtKB/Swiss-Prot: RB27B_HUMAN, O00194
Tissue specificity: Expressed primarily in testis

    SABiosciences Custom PCR Arrays for RAB27B
Primer
Products:		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAB27B
Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RAB27B
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAB27B
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAB27B
In Situ
Assay Products: 
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB27B

Orthologs
for RAB27B gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of eukaryotes.

Orthologs for RAB27B gene from 7/25 species (see all 25)    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
lizard
(Anolis carolinensis)		 Reptilia RAB27B6
 --
 89(a)
 1 ↔ 1
 GL343213.1(321304-330825)
African clawed frog
(Xenopus laevis)		 Amphibia Xl.163002 Xenopus laevis transcribed sequence with moderate similarity more 81.79(n)    CA982597.1 
zebrafish
(Danio rerio)		 Actinopterygii LOC5617171 ras-related protein Rab-27B-like 72.04(n)
83.41(a)		   561717  XM_680769.4  XP_685861.3 
fruit fly
(Drosophila melanogaster)		 Insecta EG:80H7.43 GTP binding 60(a)     --
worm
(Caenorhabditis elegans)		 Secernentea 4R79.23 Ras family 42(a)   IV(17480552-17483486)   --
thale cress
(Arabidopsis thaliana)		 eudicotyledons RAB8C6
RAB8A6
(see all 5)		 Ras-related protein ARA-3
(see all 5)		 40(a)
39(a)
(see all 5)		 possible ortholog
possible ortholog
(see all 5)		 5(883447-885425)
3(16917589-16920018)
rice
(Oryza sativa)		 Liliopsida --
--
(see all 4)		 ras-related protein, putative, expressed
(see all 4)		 40(a)
40(a)
(see all 4)		 possible ortholog
possible ortholog
(see all 4)		 7(5144086-5147755)
7(7741968-7745786)


ENSEMBL Gene Tree for RAB27B (if available)
TreeFam Gene Tree for RAB27B (if available) 

Paralogs
for RAB27B gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for RAB27B gene
RAB232  RAB27A2  RAB3A2  RAB3B2  RAB3D2  RAB3C2  
18/79 SIMAP similar genes for RAB27B using alignment to 3 protein entries:     RB27B_HUMAN (see all proteins) (see all similar genes):
RAB27A    RAB8B    RAB3A    RAB3B    RAB7L1    RAB3D
RAB37    RAB35    RAB15    RAB26    RAB3C    RAB8A
RAB4B    RAB11A    RAB7A    RAB17    RRAS2    RAB13

RAB27B for paralogs           About GeneDecksing



Genomic Variants
for RAB27B gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/1244 NCBI SNPs in RAB27B are shown (see all 1244)     About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance		Chr 18 posSequence#AA
Chg		TypeMore#Allele
freq		PopTotal
sample		More
----------
rs1495319151,2
--52493750(+) AACCTC/TGGAGA 1 -- us2k10--------
rs1462141921,2
--52493793(+) GCTATA/CCCTGC 1 -- us2k10--------
rs1929357201,2
--52493803(+) CAAGAA/GTTGGC 1 -- us2k10--------
rs1388245071,2
--52493990(+) TTGAAC/TTTCAT 1 -- us2k10--------
rs1848379501,2
--52494017(+) ACTGCA/GACTTT 1 -- us2k10--------
rs1897141371,2
--52494066(+) AAATAC/TAATAG 1 -- us2k10--------
rs1808768271,2
--52494073(+) ATAGAC/TGCCTT 1 -- us2k10--------
rs1126148431,2
C,--52494093(+) ACAGTG/AATGTT 1 -- us2k11Minor allele frequency- A:0.50NA 2
rs1474726891,2
--52494121(+) TGAAAC/TTCTAT 1 -- us2k10--------
rs1839478981,2
--52494145(+) TAATAA/GCTATT 1 -- us2k10--------

HapMap Linkage Disequilibrium report for RAB27B (52385091 - 52562747 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for RAB27B
     1 CNV: 88863
     1 Indel: 50007

SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAB27B
DNA2.0 Custom Variant and Variant Library Synthesis for RAB27B

Disorders / Diseases
for RAB27B gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
RAB27B for disorders           About GeneDecksing

OMIM gene information: 603869    OMIM disorders: --

11 diseases for RAB27B:    About MalaCards
platelet storage pool deficiency    griscelli syndrome    choroideremia    hepatitis b
hermaphroditism    breast cancer    hepatitis    pancreatitis
malaria    neuronitis    choroiditis

2 diseases from the University of Copenhagen DISEASES database for RAB27B:
Birt-Hogg-Dube syndrome     Platelet storage pool deficiency
Human Genome Epidemiology (HuGE) Navigator: RAB27B (2 documents)

Export disorders for RAB27B gene to outside databases

Publications
for RAB27B gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for RAB27B gene, integrated from 9 sources (see all 31):
(articles sorted by number of sources associating them with RAB27B)		    Utopia: connect your pdf to the dynamic
world of online information

  1. Molecular cloning and characterization of rab27a and rab27b, novel human rab proteins shared by melanocytes and platelets. (PubMed id 9066979)1, 2, 3, 9 Chen D.... Gahl W.A. (1997)
  2. Chromosomal mapping, gene structure and characterization of the human and murine RAB27B gene. (PubMed id 11178108)1, 2, 9 Ramalho J.S.... Seabra M.C. (2001)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  4. Purification, identification, and characterization of two GTP-binding proteins with molecular weights of 25,000 and 21,000 in human platelet cytosol. One is the rap1/smg21/Krev-1 protein and the other is a novel GTP-binding protein. (PubMed id 2507536)1, 2 Nagata K....Nozawa Y. (1989)
  5. Intramanchette transport during primate spermiogenesis: expression of dynein, myosin Va, motor recruiter myosin Va, VIIa-Rab27a/b interacting protein, and Rab27b in the manchette during human and monkey spermiogenesis. (PubMed id 18478159)1, 9 Hayasaka S....Okamura K. (2008)
  6. Rab27b regulates c-kit expression by controlling the s ecretion of stem cell factor. (PubMed id 22349512)1 Tanaka C....Tohyama Y. (2012)
  7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
  8. Rab27b localizes to the tubulovesicle membranes of ga stric parietal cells and regulates acid secretion. (PubMed id 20888820)1 Suda J....Karvar S. (2011)
  9. Absence of mutation in the RAB27B gene in patients wi th platelet delta-storage pool deficiency. (PubMed id 21198862)1 Masliah-Planchon J....Tapon-BretaudiA"re J. (2011)
  10. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)

External Searches for RAB27B gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing RAB27B gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 5874 HGNC: 9767 AceView: RAB27B Ensembl:ENSG00000041353 euGenes: HUgn5874
ECgene: RAB27B Kegg: 5874 H-InvDB: RAB27B

Other Databases showing RAB27B gene

(According to HUGE)
About This Section
   --

Specialized Databases showing RAB27B gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for RAB27B Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for RAB27B Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property
for RAB27B gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for RAB27B gene:
Search GeneIP for patents involving RAB27B

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
for RAB27B gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

 
 EMD Millipore Custom Antibody & Bulk Services
 EMD Millipore Preclinical / Clinical Development Services
 EMD Millipore Immunoassay Services
 EMD Millipore Target Screening & Profiling Services

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
 Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
 Browse OriGene Antibodies   OriGene shRNA RFP for RAB27B  
 OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAB27B   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAB27B  
 OriGene Protein Over-expression Lysate for RAB27B   Browse OriGene Fluorogenic Cell Assay Kits  
 OriGene siRNA for RAB27B   OriGene 3'-UTR Clone for RAB27B  
 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAB27B   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAB27B  
 Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
 Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
 OriGene Purified Protein for RAB27B   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for RAB27B   OriGene Custom Protein Services for RAB27B  
 OriGene Custom Immunoassay Development  

 		 
 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RAB27B
 QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAB27B
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB27B
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAB27B
 QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAB27B
 QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAB27B
 GenScript Custom Purified and Recombinant Proteins Services for RAB27B GenScript cDNA clones with any tag delivered in your preferred vector for RAB27B
 GenScript Custom Assay Services for RAB27B GenScript Custom Superior Antibodies Services for RAB27B
 GenScript Custom overexpressing Cell Line Services for RAB27B CloneReady with Over 120,000 Genes
 Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
 Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
 Custom Peptide Services
 Search for Antibodies & Assays

 Regulatory tfbs in RAB27B promoter
 Search Chromatin IP Primers for RAB27B
 RT2 qPCR Primer Assay in human, mouse, rat RAB27B
 GNC Network for RAB27B
 SABiosciences PCR Arrays including human, mouse, rat RAB27B
 Search Tocris compounds for RAB27B
 Browse Sino Biological Proteins and Antibodies
 Browse Sino Biological cDNA Clones
 Antibodies/Proteins Production Services
 Rabbit Monoclonal Antibody Platform
 Bulk Purchasing
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
 Novus Tissue Slides
 RAB27B antibodies
 RAB27B proteins
 RAB27B lysates
 Search for Antibodies for RAB27B at Abcam
 See all of Abcam's Antibodies, Kits and Proteins for RAB27B
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Recombinant Protein for RAB27B




 RAB27B Proteins, Antibodies, CLIAs, and ELISAs
 Search LifeMap BioReagents cell lines for RAB27B
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB27B
 SwitchGear 3'UTR luciferase reporter plasmids for RAB27B
 SwitchGear Promoter luciferase reporter plasmids for RAB27B
 ThermoFisher Antibodies for RAB27B
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB27B
       
GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category
VWF
(GIFTS: 73)
von Willebrand factor
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
Hot genes      Disease genes      RAB27B gene at Home site.
hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4