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Aliases & Descriptions for RAB27B
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| | | Descriptions |
|---|
| RAB27B, member RAS oncogene family 2 |
|
| | Search outside databases for aliases for RAB27B genePrevious GC identifers: GC18P052584 GC18P052398 GC18P052280 GC18P050644 |
Summaries for RAB27B(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: RB27B_HUMAN, O00194Function: May be involved in targeting uroplakins to urothelial apical membranes (By similarity) |
Genomic Location for RAB27B
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the RAB27B gene 
Entrez Gene cytogenetic band: 18q21.2 Ensembl cytogenetic band: 18q21.2 HGNC cytogenetic band: 18q21.2RAB27B Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 18 GeneLoc Exon Structure GeneLoc location for GC18P050646:
(about GC identifiers)
Start:
|
50,646,706 bp from pter |
End:
|
50,708,210 bp from pter |
Size:
|
61,505 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000018.8 NT_025028.13
| Proteins for RAB27B
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: RB27B_HUMAN, O00194 (See
protein sequence)Recommended Name: Ras-related protein Rab-27B Size: 218 amino acids; 24608 Da
Subunit: Binds SYTL4 and MYRIP (By similarity)
Subcellular location: Membrane; Lipid-anchor
PDB structures from and Proteopedia :2F7S (3D)
 
Secondary accessions: Q9BZB6REFSEQ proteins: NP_004154.2
ENSEMBL proteins: ENSP00000262094
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: RAB27B 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for RAB27B: Assays for RAB27B: | Protein
Domains/ Families for RAB27B(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry O00194
ProtoNet protein and cluster: O00194 1 Blocks protein family: IPB001806 Transforming protein P21 RAS signature
UniProtKB/Swiss-Prot: RB27B_HUMAN, O00194Similarity: Belongs to the small GTPase superfamily. Rab family | Gene Function for RAB27B
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004163
Applied Biosystems Silencer® siRNAs for RAB27B
Sigma-Aldrich siRNA for RAB27B  Sigma-Aldrich shRNA for RAB27B  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004163                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_004163                                  untagged cDNA clones in CMV expression vector (see all 2): NM_004163 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_004163
UniProtKB/Swiss-Prot: RB27B_HUMAN, O00194Function: May be involved in targeting uroplakins to urothelial apical membranes (By similarity)9 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Rab27b):
4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for RAB27B
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for RAB27B 
5/9 Interacting proteins for RAB27B (ENSP000002620943) via UniProtKB, MINT, and/or STRING (see all 9
)About this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007264 | small GTPase mediated signal transduction |
IEA | -- | | GO:0015031 | protein transport |
IEA | -- | About this table
|
Drugs & Compounds for RAB27B(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|  |
Enzo Life Sciences drugs & compounds for RAB27B |
Browse Tocris compounds for RAB27B
|
Transcripts for RAB27B(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004163
Sigma-Aldrich siRNA for RAB27B  Sigma-Aldrich shRNA for RAB27B  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_004163 REFSEQ mRNAs for RAB27B gene: NM_004163.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_004163               OriGene GFP tagged cDNA clone in CMV expression vector: NM_004163                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_004163                                  untagged cDNA clones in CMV expression vector (see all 2): NM_004163  Additional cDNA sequence: AF131784.1 AF329499.1 AF498954.1 AK314115.1 BC027474.1 U57093.2 6 DOTS entries: DT.40110267 DT.307484 DT.97816796 DT.121084137 DT.91695544 DT.97837249 24/59 AceView cDNA sequences (see all 59
):BC027474 BU618369 AF329499 BF002851 NM_004163 AF498954 CB565911 AL707788 BX281002 AI277199 BQ723291 CA335387 BF438386 BG195281 AA846320 BG620768 BM985425 BU752963 BQ020683 AF131784 AW340618 AW468475 AW664866 BX952196
highest scoring ESTs for RAB27B:AI432357 U57093 AA812916 AF329499 AF498954 AW592937 BC027474 BG195281 BG284004 BU618369 Unigene Cluster for RAB27B: RAB27B, member RAS oncogene family Hs.25318 [show with all ESTs]Unigene Representative Sequence: AF131784
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for RAB27B
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | |
| SP1: | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | - |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for RAB27B
1 Ensembl transcript including schematic representation: ENST00000262094
|
Expression for RAB27B
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| RAB27B expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for RAB27B
1 / 2 / 3 6 probe-sets matching RAB27B gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TACAAATAGG
SOURCE GeneReport for Unigene cluster: Hs.25318
Expression variation in blood from EXPOLDB for RAB27B UniProtKB/Swiss-Prot: RB27B_HUMAN, O00194Tissue specificity: Expressed primarily in testis |
Orthologs for RAB27B
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for RAB27B gene from 5/11 species (see all 11
)
About this table Species with no ortholog for RAB27B
ENSEMBL Gene Tree for RAB27B | Paralogs for RAB27B(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for RAB27B gene
- RAB27A2 RAB262 RAB372
|
SNPs/Variants for RAB27B(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for RAB27B (up to first 250kb)
|
Disorders & Mutations for RAB27B
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 603869
|
Medical News for RAB27B(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for RAB27B (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/17 PubMed articles for RAB27B gene (see all 17
):- Molecular cloning and characterization of rab27a and rab27b, novel human rab proteins shared by melanocytes and platelets. (PubMed id 9066979)1, 2, 3, 4 Chen D.... Gahl W.A. (1997)
- Chromosomal mapping, gene structure and characterization of the human and murine RAB27B gene. (PubMed id 11178108)1, 3, 4 Ramalho J.S.... Seabra M.C. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Purification, identification, and characterization of two GTP-binding proteins with molecular weights of 25,000 and 21,000 in human platelet cytosol. One is the rap1/smg21/Krev-1 protein and the other is a novel GTP-binding protein. (PubMed id 2507536)3, 4 Nagata K....Nozawa Y. (1989)
- Intramanchette transport during primate spermiogenesis: expression of dynein, myosin Va, motor recruiter myosin Va, VIIa-Rab27a/b interacting protein, and Rab27b in the manchette during human and monkey spermiogenesis. (PubMed id 18478159)1, 3 Hayasaka S....Okamura K. (2008)
- Munc13-4 is a GTP-Rab27-binding protein regulating dense core granule secretion in platelets. (PubMed id 14699162)3 Shirakawa R....Horiuchi H. (2004)
- Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2. (PubMed id 12578829)3 Fukuda M. (2003)
- A role for Rab27b in NF-E2-dependent pathways of platelet formation. (PubMed id 12907454)3 Tiwari S....Shivdasani R.A. (2003)
- Involvement of Rab27b in the regulated secretion of pituitary hormones. (PubMed id 11956164)3 Zhao S....Izumi T. (2002)
- Functional redundancy of Rab27 proteins and the pathogenesis of Griscelli syndrome. (PubMed id 12122117)3 Barral D.C....Seabra M.C. (2002)
|
Search for RAB27B
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing RAB27B
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing RAB27B
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RAB27B(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for RAB27B(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for RAB27B:

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