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RAB27A Gene

protein-coding GIFtS: 66

GC15M053283

RAB27A, member RAS oncogene family
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
GS2 ^¹, ², ⁵
HsT18676 ^¹, ²
MGC117246 ^²
RAB27 ^¹, ², ³
RAM ^¹, ², ⁵
Rab-27 ^³

Descriptions
GTP-binding protein Ram ^², ³
RAB27A, member RAS oncogene family ^²
Ras-related protein Rab-27A ^²

External Ids
HGNC: 9766¹
Entrez Gene: 5873²
UniProtKB: P51159³
Ensembl: ENSG00000069974⁷

Search outside databases for aliases for RAB27A gene

Previous GC identifers: GC15M051054 GC15M048542 GC15M053075 GC15M053211

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for RAB27A:

The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The protein

is membrane-bound and may be involved in protein transport and small GTPase mediated signal

transduction. Mutations in this gene are associated with Griscelli syndrome type 2. Alternative

splicing occurs at this locus and four transcript variants encoding the same protein have been

identified. [provided by RefSeq]

Gene Wiki entry for RAB27A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the RAB27A gene

Entrez Gene cytogenetic band: 15q15-q21.1 Ensembl cytogenetic band: 15q21.3 HGNC cytogenetic band: 15q15-q21.1

RAB27A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15M053283: (about GC identifiers)

Start:	53,283,084 bp from pter
End:	53,369,293 bp from pter
Size:	86,210 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000015.8 NT_010194.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: RB27A_HUMAN, P51159 (See protein sequence)

Recommended Name: Ras-related protein Rab-27A

Size: 221 amino acids; 24868 Da

Subunit: Binds SYTL1, SYTL2, SLAC2B, MYRIP, SYTL3, SYTL4 and SYTL5 (By similarity). Binds MLPH

Subcellular location: Membrane; Lipid-anchor. Melanosome. Note=Identified by mass spectrometry in

melanosome fractions from stage I to stage IV

Secondary accessions: O00195 Q6FI40 Q9UIR9 Q9Y5U3

Alternative splicing: 2 isoforms: P51159-1 P51159-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (4 alternative transcripts):

NP_004571.2 NP_899057.1 NP_899058.1 NP_899059.1

ENSEMBL proteins:

ENSP00000337761 ENSP00000379601 ENSP00000379598

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (RAB27A)
	Human Recombinant Proteins from Abnova (RAB27A)

OriGene Purified Recombinant Human Protein: RAB27A

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	18029348
GO:0016020	membrane	IEA	--
GO:0030425	dendrite	IDA	11266474
GO:0042470	melanosome	IDA	11266474

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Antibodies for RAB27A:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for RAB27A
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (RAB27A), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (RAB27A)
	Novus Biologicals Antibodies for RAB27A

Assays for RAB27A:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P51159

ProtoNet protein and cluster: P51159

1 Blocks protein family: IPB001806 Transforming protein P21 RAS signature

UniProtKB/Swiss-Prot: RB27A_HUMAN, P51159

Similarity: Belongs to the small GTPase superfamily. Rab family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (RAB27A)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (RAB27A)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_004580

Applied Biosystems Silencer® siRNAs for RAB27A

Sigma-Aldrich siRNA and siRNA Panels for RAB27A

Sigma-Aldrich shRNA for RAB27A

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_004580
Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_004580
untagged cDNA clones in CMV expression vector (see all 4): NM_004580

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_183236

Genatlas biochemistry entry for RAB27A:

RAB27A,RAS oncogene superfamily member,prenylated by REP1 and unprenylated in CHM patients with an

alternatively polyadenylation sites

10 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Rab27a):

cellular	endocrine/exocrine gland	hematopoietic system	homeostasis/metabolism	immune system
nervous system	pigmentation	reproductive system	skin/coat/nails	vision/eye

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003924	GTPase activity	TAS	9066979
GO:0005525	GTP binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Gene Network Central^TM Interacting Genes and Proteins Network for RAB27A

5/54 Interacting proteins for RAB27A (P51159² ENSP00000337761³) via UniProtKB, MINT, and/or STRING (see all 54 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MLPH	Q9BV36², ENSP00000264605³	MINT-3388073 MINT-3388107 STRING (score=.999)
MYO5A	Q9Y4I1², ENSP00000350945³	MINT-3388073 STRING (score=.999)
C14orf1	Q9UKR5²	MINT-63846
COPS6	Q7L5N1²	MINT-63841
GDF9	O60383²	MINT-63839

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007264	small GTPase mediated signal transduction	IEA	--
GO:0015031	protein transport	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for RAB27A

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for RAB27A
5 Novoseek chemical compound relationships for RAB27A gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
gtp	50.32	7	16923811 (1), 12446441 (1), 16630545 (1), 12531900 (1)
gdp	47.34	4	12446441 (1), 12006666 (1), 16630545 (1)
silver	2.76	1	15632015 (1)
sodium	0.00	3	16236259 (2), 16630545 (1)
glucose	0.00	2	15690086 (2)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (RAB27A)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (RAB27A)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_004580

Sigma-Aldrich siRNA and siRNA Panels for RAB27A

Sigma-Aldrich shRNA for RAB27A

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004580 NM_183234 NM_183235 NM_183236

REFSEQ mRNAs for RAB27A gene (4 alternative transcripts):

NM_004580.3 NM_183234.1 NM_183235.1 NM_183236.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004580 NM_183234 NM_183235 NM_183236

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_004580
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_004580
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_004580

Additional cDNA sequence:

AF125393.1 AF498953.1 AK312836.1 BC107680.1 BC132800.1 BC136423.1 CR457076.1 CR536496.1

CR541693.1 U38654.3 U57094.1

15 DOTS entries:

DT.453964 DT.95144894 DT.100020791 DT.100783078 DT.100783075 DT.121055527 DT.424986 DT.95172375

DT.100703883 DT.100783077 DT.75149054 DT.92432952 DT.95100695 DT.95332837 DT.106353

24/152 AceView cDNA sequences (see all 152 ):

BG760453 BE349443 CB159742 BM472660 AI246340 CR536496 AA278355 BM759182

NM_183236 AW468494 BM800922 BM014705 AW849487 CD676702 AI969654 BQ427808

NM_183234 BM313622 CB565912 BM557278 AI434808 BQ678619 AW080916 BQ020782

highest scoring ESTs for RAB27A:

AL120794 AV661679 AV751976 U57094 AA215624 AA251898 AA278343 AA345803 AA478644 AA506404

Unigene Cluster for RAB27A:

RAB27A, member RAS oncogene family

Hs.654978 [show with all ESTs]

Unigene Representative Sequence: NM_004580

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for RAB27A

ExUns:	1	^	2	^	3a	·	3b	^	4a	·	4b	^	5	^	6	^	7	^	8	^	9a	·	9b
SP1:					-				-		-
SP2:											-
SP3:									-		-
SP4:			-		-

About this scheme

ECgene alternative splicing isoforms for RAB27A

3 Ensembl transcripts including schematic representations:

ENST00000336787 ENST00000396307 ENST00000396304

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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RAB27A expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for RAB27A

¹ / ² / ³

9 probe-sets matching RAB27A gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
65080_r_at²^{, 3}	U95-C	1	1.00	1.00	0.89	1.04	AI557479	0.60	1.00	0.82	1
809_at²^{, 3}	U95-A	1	1.00	1.00	0.95	1.19	U57094	0.80	1.00	0.91	1
40669_at²^{, 3}	U95-A	1	0.56	1.00	0.88	0.79	U57094	0.80	1.00	0.91	1
210951_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF125393	0.40	1.00	0.76	1
209514_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BE502030	0.60	1.00	0.82	1
209515_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U38654	0.60	1.00	0.82	1
210951_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209514_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209515_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks RAB27A for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GCACAGTGAG

SOURCE GeneReport for Unigene cluster: Hs.654978
Expression variation in blood from EXPOLDB for RAB27A
UniProtKB/Swiss-Prot: RB27A_HUMAN, P51159
Tissue specificity: Found in all the examined tissues except in brain. Low expression was found in
thymus, kidney, muscle and placenta. Detected in melanocytes, and in most tumor cell lines
examined

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for RAB27A gene from 5/12 species (see all 12 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	RAB27A¹	--	RAB27A, member RAS oncogene family	92.46(n) 95.48(a)	608699 XM_846225.1 XP_851318.1
chimpanzee (Pan troglodytes)	RAB27A¹	--	RAB27A, member RAS oncogene family	99.4(n) 98.64(a)	453455 XM_001170867.1 XP_001170867.1
cow (Bos taurus)	RAB27A¹	--	RAB27A, member RAS oncogene family	90.05(n) 94.12(a)	618035 XM_870366.2 XP_875459.1
rat (Rattus norvegicus)	Rab27a¹	--	RAB27A, member RAS oncogene family	86.88(n) 96.38(a)	50645 NM_017317.2 NP_059013.1
mouse (Mus musculus)	Rab27a^{1, 5}	9 (41.00 cM)⁵	RAB27A, member RAS oncogene family^{1, 5}	88.08(n)¹ 95.93(a)¹	11891¹ NM_023635.3¹ NP_076124.1¹ AB046693⁵ AB120511⁵ (see all 21)

About this table Species with no ortholog for RAB27A

ENSEMBL Gene Tree for RAB27A

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for RAB27A gene

RAB26² RAB27B² RAB37²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/577 NCBI SNPs in RAB27A are shown (see all 577 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 196)

AB	SNP ID	Valid	Chr 15 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1061824^1,2	A,C,F,H,O	53283255(-)	`ATTGTA/GTATGC`	4	--	ut3¹ ese³		5		MN EU EA WA	600
	rs6493774^1,2	A,C,F,H	53352038(+)	`TACCAT/ATTTTC`	2	--	ng3¹ int¹		8		EU EA WA	834
	rs3179664^1,2	A,C,F,H	53284145(-)	`ATTTGC/TGATGA`	4	--	ut3¹		8		MN NA EU EA WA	716
	rs1061823^1,2	A,C,F,H	53283335(-)	`GTAAAA/TTTTTA`	4	--	ut3¹		5		MN EU EA WA	594
	rs1061873^1,2	A,C,F,H	53284048(-)	`TCTCTA/GTCTTT`	4	--	ut3¹		5		MN EU EA WA	596
	rs1050931^1,2	A,C,F,H	53284983(-)	`GTAAGC/TGACAT`	4	--	ut3¹		5		MN EU EA WA	596
	rs1061870^1,2	A,C,F,H	53284061(-)	`TATAAC/ATTACT`	4	--	ut3¹		5		MN EU EA WA	586
	rs1061822^1,2	A,C,F	53283350(-)	`ACTTAT/GCCATG`	4	--	ut3¹		1		MN	184
	rs1061821^1,2	A,C,H	53283403(-)	`TCATGA/GAAAAA`	4	--	ut3¹		4		MN EU EA	472
--	rs6493769^1,2	A,C	53282990(+)	`agctcC/Tgcctc`	4	--	ng5¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for RAB27A (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 603868 disorders: 607624

UniProtKB/Swiss-Prot: RB27A_HUMAN, P51159

Defects in RAB27A are a cause of Griscelli syndrome type-2 (GS2) [MIM:607624]. Griscelli

syndrome is a rare autosomal recessive disorder that results in pigmentary dilution of the skin

and hair, the presence of large clumps of pigment in hair shafts, and an accumulation of

melanosomes in melanocytes. GS2 patients also develop an uncontrolled T-lymphocyte and macrophage

activation syndrome, known as hemophagocytic syndrome, leading to death in the absence of bone

marrow transplantation. Neurological impairment is present in some patients, likely as a result of

hemophagocytic syndrome

8 Novoseek disease relationships for RAB27A gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
griscelli syndrome, type 2	96.59	5	16278825 (1), 12446441 (1), 18991284 (1), 18350256 (1) (see all 5)
piebaldism	94.60	8	15713878 (1), 15163896 (1), 12446441 (1), 12531900 (1) (see all 6)
lymphohistiocytosis hemophagocytic	74.94	5	18311812 (1), 11571516 (1), 16278825 (1), 18991284 (1) (see all 5)
chediak-higashi syndrome	68.24	2	17088644 (1), 16962048 (1)
familial hemophagocytic lymphohistiocytosis	65.19	2	16962048 (1)
immunodeficiency	25.59	4	15713878 (1), 11571516 (1), 15690086 (1), 11178108 (1)
melanoma	14.52	6	11773082 (2), 9066979 (1), 18281284 (1)
tumors	0.00	2	19212825 (1)

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Human Gene Mutation Database: RAB27A
Human Genome Epidemiology Navigator: RAB27A (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/118 PubMed articles for RAB27A gene (see all 118 ):

Deficient geranylgeranylation of Ram/Rab27 in choroideremia. (PubMed id 7592656)^{2, 3, 4} Seabra M.C.... Anant J.S. (1995)
Characterization of the molecular defects in Rab27a, caused by RAB27A missense mutations found in patients with Griscelli syndrome. (PubMed id 12531900)^{1, 3, 4} Bahadoran P....Ballotti R. (2003)
Biochemical and functional characterization of Rab27a mutations occurring in Griscelli syndrome patients. (PubMed id 12446441)^{1, 3, 4} Menasche G.... de Saint Basile G. (2003)
Molecular cloning and characterization of rab27a and rab27b, novel human rab proteins shared by melanocytes and platelets. (PubMed id 9066979)^{1, 3, 4} Chen D.... Gahl W.A. (1997)
Mutations in RAB27A cause Griscelli syndrome associated with haemophagocytic syndrome. (PubMed id 10835631)^{1, 3, 4} Menasche G....de Saint Basile G. (2000)
Cloning, mapping and characterization of the human RAB27A gene. (PubMed id 10571040)^{1, 3, 4} Tolmachova T....Seabra M.C. (1999)
Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)^{3, 4} Chi A....Hunt D.F. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Proteomic analysis of early melanosomes: identification of novel melanosomal proteins. (PubMed id 12643545)^{3, 4} Basrur V.... Appella E. (2003)
Melanophilin directly links Rab27a and myosin Va through its distinct coiled-coil regions. (PubMed id 12062444)^{3, 4} Nagashima K....Izumi T. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 5873	HGNC: 9766	AceView: RAB27A	Ensembl:ENSG00000069974	euGenes: HUgn5873
ECgene: RAB27A	H-InvDB: RAB27A

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for RAB27A	Genetics and Cytogenetics in Oncology and Haematology
RAB27Abase	http://bioinf.uta.fi/RAB27Abase/
Mutations of the RAB27A gene	http://www.retina-international.com/sci-news/rab27mut.htm

Licensable Technologies for RAB27A
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for RAB27A:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for RAB27A-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for RAB27A		Antibodies for RAB27A
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for RAB27A		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
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	Recombinant Proteins (RAB27A)
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Antibodies for RAB27A

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RAB27A Gene at Home site.
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RAB27A Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for RAB27A

Summaries
for RAB27A

Genomic Location
for RAB27A

Proteins
for RAB27A

Protein Domains/
Families
for RAB27A

Gene Function
for RAB27A

Pathways & Interactions
for RAB27A

Drugs & Compounds
for RAB27A

Transcripts
for RAB27A

Expression
for RAB27A

Orthologs
for RAB27A

Paralogs
for RAB27A

SNPs/Variants
for RAB27A

Disorders & Mutations
for RAB27A

Medical News
for RAB27A

Publications
for RAB27A

Search for RAB27A

Genome Databases showing RAB27A

Other Databases showing RAB27A

Specialized Databases showing RAB27A

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for RAB27A

Services
for RAB27A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

RAB27A Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor RAB27A

Summariesfor RAB27A

Genomic Locationfor RAB27A

Proteinsfor RAB27A

Protein Domains/Familiesfor RAB27A

Gene Functionfor RAB27A

Pathways & Interactionsfor RAB27A

Drugs & Compoundsfor RAB27A

Transcriptsfor RAB27A

Expression for RAB27A

Orthologsfor RAB27A

Paralogsfor RAB27A

SNPs/Variantsfor RAB27A

Disorders & Mutationsfor RAB27A

Medical Newsfor RAB27A

Publicationsfor RAB27A

Search for RAB27A

Genome Databases showing RAB27A

Other Databases showing RAB27A

Specialized Databases showing RAB27A

Licensable Technologiesfor RAB27A

Servicesfor RAB27A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for RAB27A

Summaries
for RAB27A

Genomic Location
for RAB27A

Proteins
for RAB27A

Protein Domains/
Families
for RAB27A

Gene Function
for RAB27A

Pathways & Interactions
for RAB27A

Drugs & Compounds
for RAB27A

Transcripts
for RAB27A

Expression
for RAB27A

Orthologs
for RAB27A

Paralogs
for RAB27A

SNPs/Variants
for RAB27A

Disorders & Mutations
for RAB27A

Medical News
for RAB27A

Publications
for RAB27A

Licensable Technologies
for RAB27A

Services
for RAB27A