RAB27A Gene
protein-coding GIFtS: 65
GCID: GC15M055495
|
|
RAB27A, member RAS oncogene family
| |
Aliases
for RAB27A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| RAB27A, Member RAS Oncogene Family1 2 | | GTP-Binding Protein Ram2 3 | | RAB271 2 3 | | Rab-273 | | GS21 2 5 | | Ras-Related Protein Rab-27A2 | | RAM1 2 5 | | Rab-273 | | HsT186761 2 | | |
Export aliases for RAB27A gene to outside databasesPrevious GC identifers: GC15M051054 GC15M048542 GC15M053075 GC15M053211 GC15M053283 GC15M032321 |
Summaries
for RAB27A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RAB27A:
The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound andmay be involved in protein transport and small GTPase mediated signal transduction. Mutations in this gene areassociated with Griscelli syndrome type 2. Alternative splicing occurs at this locus and four transcript variantsencoding the same protein have been identified. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: RB27A_HUMAN, P51159Function: Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granuledocking and priming at the immunologic synapse
Gene Wiki entry for RAB27A
|
Genomic Views
for RAB27A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010194.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RAB27A gene promoter:
Bach1
Other transcription factors
Search SABiosciences Chromatin IP Primers for RAB27A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB27A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q15-q21.1 Ensembl cytogenetic band: 15q21.3 HGNC cytogenetic band: 15q15-q21.1RAB27A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15M055495: view genomic region
(about GC identifiers)
Start:
|
55,495,164 bp from pter |
End:
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55,611,311 bp from pter |
Size:
|
116,148 bases |
Orientation:
|
minus strand |
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Proteins
for RAB27A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RB27A_HUMAN, P51159 (See
protein sequence)Recommended Name: Ras-related protein Rab-27A Size: 221 amino acids; 24868 Da
Subunit: Binds SYTL1, SLAC2B, MYRIP, SYTL3, SYTL4 and SYTL5. Interacts with RPH3A and RPH3A (By similarity). Binds MLPHand SYTL2. Interacts with UNC13D
Subcellular location: Membrane; Lipid-anchor. Melanosome. Late endosome. Lysosome. Note=Identified by mass spectrometryin melanosome fractions from stage I to stage IV. Localizes to endosomal exocytic vesicles
Secondary accessions: O00195 Q6FI40 Q9UIR9 Q9Y5U3Alternative splicing: 2 isoforms: P51159-1 P51159-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for RAB27A: NX_P51159
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P51159
RAB27A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_004571.2 NP_899057.1 NP_899058.1 NP_899059.1
ENSEMBL proteins: ENSP00000379601 ENSP00000455012 ENSP00000456059 ENSP00000454695 ENSP00000458127 ENSP00000456536 ENSP00000457595 ENSP00000457517 ENSP00000337761 Reactome Protein details: P51159
Human Recombinant Protein Products for RAB27A:
Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11): About this table
RAB27A for ontologies About GeneDecksing
RAB27A Antibody Products:
Assay Products for RAB27A: |
Protein
Domains /
Families
for RAB27A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RAB27A for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P51159ProtoNet protein and cluster: P51159 1 Blocks protein family: IPB001806 Transforming protein P21 RAS signature
UniProtKB/Swiss-Prot: RB27A_HUMAN, P51159Similarity: Belongs to the small GTPase superfamily. Rab family |
Function
for RAB27A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: RB27A_HUMAN, P51159Function: Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granuledocking and priming at the immunologic synapse Genatlas biochemistry entry for RAB27A:RAB27A,RAS oncogene superfamily member,prenylated by REP1 and unprenylated in CHM patients with an alternativelypolyadenylation sites
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
RAB27A for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for RAB27A:
10 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Rab27a):
RAB27A for phenotypes About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAB27A (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAB27A (see all 4)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): RAB27A (NM_183235) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RAB27A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB27A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB27A |
|
Pathways & Interactions
for RAB27A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Insulin Processing | | | 2 | Deregulation of Rab and Rab Effector Genes in Bladder Cancer | | | 3 | wtCFTR and deltaF508 traffic / Late endosome and Lysosome (norm and CF) | | | 4 | Exocytosis of Insulin | | | 5 | Clathrin-dependent protein traffic | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RAB27A
2  GeneGo (Thomson Reuters) Pathways for RAB27A
1  BioSystems Pathway for RAB27A
4 
Reactome Pathways for RAB27A
RAB27A for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAB27A
STRING Interaction
Network Preview (showing 5 interactants - click image to see 23)
5/41 Interacting proteins for RAB27A (P511592, 3 ENSP000003377614) via UniProtKB, MINT, STRING, and/or I2D (see all 41)About this table
Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17): About this table
RAB27A for ontologies About GeneDecksing
|
Drugs & Compounds
for RAB27A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
RAB27A for compounds About GeneDecksing
 Browse Tocris compounds for RAB27A
5 Novoseek chemical compound relationships for RAB27A gene About this table
Search CenterWatch for drugs/clinical trials and news about RAB27A / RB27A
|
Transcripts
for RAB27A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RAB27A gene (4 alternative transcripts): NM_004580.4 NM_183234.2 NM_183235.2 NM_183236.2 Unigene Cluster for RAB27A: RAB27A, member RAS oncogene family Hs.654978 [show with all ESTs]Unigene Representative Sequence: NM_00458012 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000396307(uc002aco.3 uc002acp.3 uc002acq.3 uc002acr.3)
ENST00000564609 ENST00000569493 ENST00000566877 ENST00000567380 ENST00000565972
ENST00000563262 ENST00000568803 ENST00000567639 ENST00000565776 ENST00000561545
ENST00000336787
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAB27A (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAB27A (see all 4)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): RAB27A (NM_183235) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RAB27A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB27A |
Additional cDNA sequence: AF125393.1 AF498953.1 AK312836.1 BC107680.1 BC132800.1 BC136423.1 CR457076.1 CR536496.1 CR541693.1 U38654.3 U57094.1 14 DOTS entries: DT.453964 DT.95144894 DT.100020791 DT.100783075 DT.100783078 DT.121055527 DT.95172375 DT.100703883 DT.100783077 DT.106353 DT.75149054 DT.95100695 DT.92432952 DT.95332837 24/152 AceView cDNA sequences (see all 152): BQ188333 BM557278 AW080916 AA215624 AV716186 NM_183236 NM_004580 BM759182 BG760453 BQ776032 CA398159 NM_183235 AW849487 CB159742 CD676702 AW468494 CR541693 BM313622 NM_183234 BQ678619 CB565912 BQ427808 AI434808 AI246340
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for RAB27A About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b |
|---|
|
| SP1: | | | | | - | | | | - | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | | | | | | | | | | | | | |
| SP4: | | | - | | - | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for RAB27A
|
Expression
for RAB27A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RAB27A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCACAGTGAG
About this image
See RAB27A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RAB27A
SOURCE GeneReport for Unigene cluster: Hs.654978
UniProtKB/Swiss-Prot: RB27A_HUMAN, P51159Tissue specificity: Found in all the examined tissues except in brain. Low expression was found in thymus, kidney,muscle and placenta. Detected in melanocytes, and in most tumor cell lines examined. Expressed in cytotoxicT-lymphocytes (CTL) and mast cells
SABiosciences Custom PCR Arrays for RAB27A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAB27A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RAB27A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAB27A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAB27A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB27A |
Orthologs
for RAB27A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RAB27A gene from 8/27 species (see all 27) About this table
ENSEMBL Gene Tree for RAB27A (if available)
TreeFam Gene Tree for RAB27A (if available) |
Paralogs
for RAB27A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RAB27A gene
- RAB232 RAB3A2 RAB3B2 RAB27B2 RAB3D2 RAB3C2
18/97 SIMAP similar genes for RAB27A using alignment to 8 protein entries: RB27A_HUMAN (see all proteins)
(see all similar genes):RAB27B DKFZp686J06205 rab1b RAB8B RAB3A RAB13
RAB3D RAB3C RAB15 RAB8A RAB3B RAB10
RAB1C RAB26 RAB37 RAB35 RAB17 RAB1B
RAB27A for paralogs About GeneDecksing
|
Genomic Variants
for RAB27A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RAB27A (55495164 - 55611311 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RAB27A: --
Human Gene Mutation Database (HGMD): RAB27A
Locus Specific Mutation Databases (LSDB): RAB27A
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAB27A |
|
Disorders
/ Diseases
for RAB27A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RAB27A for disorders About GeneDecksing
OMIM gene information: 603868
OMIM disorders: 607624
UniProtKB/Swiss-Prot: RB27A_HUMAN, P51159
Defects in RAB27A are a cause of Griscelli syndrome type 2 (GS2) [MIM:607624]. Griscelli syndrome is a rareautosomal recessive disorder that results in pigmentary dilution of the skin and hair, the presence of large clumps ofpigment in hair shafts, and an accumulation of melanosomes in melanocytes. GS2 patients also develop an uncontrolledT-lymphocyte and macrophage activation syndrome, known as hemophagocytic syndrome, leading to death in the absence ofbone marrow transplantation. Neurological impairment is present in some patients, likely as a result of hemophagocyticsyndrome
20/34  diseases for RAB27A (see all 34): About MalaCardsgriscelli syndrome type 2 griscelli syndrome chediak-higashi syndrome hermansky-pudlak syndrome
hemophagocytic lymphohistiocytosis piebaldism esophageal squamous cell carcinoma squamous cell carcinoma
choroideremia pancytopenia was-related disorders microphthalmia
albinism eosinophilia neutropenia hepatitis b
hermaphroditism t lymphocyte deficiency hyperglycemia hepatocellular carcinoma
4 diseases from the University of Copenhagen DISEASES database for RAB27A:Hemophagocytic lymphohistiocytosis Choroideremia Hermansky-Pudlak syndrome Chediak-Higashi syndrome 8 Novoseek disease relationships for RAB27A gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| griscelli syndrome, type 2 |
97.4 |
11 |
20370853 (2), 19953648 (2), 16278825 (1), 12446441 (1) (see all 8) |
| piebaldism |
95.1 |
10 |
15713878 (1), 15163896 (1), 20370853 (1), 12446441 (1) (see all 8) |
| lymphohistiocytosis hemophagocytic |
75.9 |
5 |
18311812 (1), 11571516 (1), 16278825 (1), 18991284 (1) (see all 5) |
| familial hemophagocytic lymphohistiocytosis |
71.3 |
4 |
19704116 (1), 16962048 (1) |
| chediak-higashi syndrome |
66.9 |
2 |
17088644 (1), 16962048 (1) |
| immunodeficiency |
32.2 |
7 |
15713878 (1), 11571516 (1), 19704116 (1), 15690086 (1) (see all 6) |
| melanoma |
17.7 |
6 |
11773082 (2), 9066979 (1), 18281284 (1) |
| tumors |
0 |
2 |
19212825 (1) |
Human Genome Epidemiology (HuGE) Navigator: RAB27A (3 documents)
Export disorders for RAB27A gene to outside databases
|
Publications
for RAB27A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RAB27A gene, integrated from 9 sources (see all 151):
(articles sorted by number of sources associating them with RAB27A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Deficient geranylgeranylation of Ram/Rab27 in choroideremia. (PubMed id 7592656)1, 2, 3 Seabra M.C.... Anant J.S. (1995)
- Characterization of the molecular defects in Rab27a, caused by RAB27A missense mutations found in patients with Griscelli syndrome. (PubMed id 12531900)1, 2, 9 Bahadoran P....Ballotti R. (2003)
- Biochemical and functional characterization of Rab27a mutations occurring in Griscelli syndrome patients. (PubMed id 12446441)1, 2, 9 Menasche G.... de Saint Basile G. (2003)
- Molecular cloning and characterization of rab27a and rab27b, novel human rab proteins shared by melanocytes and platelets. (PubMed id 9066979)1, 2, 9 Chen D.... Gahl W.A. (1997)
- Mutations in RAB27A cause Griscelli syndrome associated with haemophagocytic syndrome. (PubMed id 10835631)1, 2, 9 Menasche G....de Saint Basile G. (2000)
- Cloning, mapping and characterization of the human RAB27A gene. (PubMed id 10571040)1, 2, 9 Tolmachova T....Seabra M.C. (1999)
- A newly identified isoform of Slp2a associates with Rab27a in cytotoxic T cells and participates to cytotoxic granule secretion. (PubMed id 18812475)1, 2 Menasche G....de Saint Basile G. (2008)
- Secretory cytotoxic granule maturation and exocytosis require the effector protein hMunc13-4. (PubMed id 17237785)1, 2 Menager M.M.... de Saint Basile G. (2007)
- Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (2006)
- Munc13-4 is an effector of rab27a and controls secretion of lysosomes in hematopoietic cells. (PubMed id 15548590)1, 2 Neeft M.... van der Sluijs P. (2005)
|
External Searches for RAB27A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RAB27A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RAB27A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RAB27A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RAB27A | Pharmacogenomics, SNPs, Pathways | | ATLAS Chromosomes in Cancer entry for RAB27A | Genetics and Cytogenetics in Oncology and Haematology | | RAB27Abase | http://bioinf.uta.fi/RAB27Abase/ | | Mutations of the RAB27A gene | http://www.retina-international.org/files/sci-news/rab27mut.htm |
|
| | |
About This Section
| Patent Information for RAB27A gene:
Search GeneIP for patents involving RAB27A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RAB27A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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| | |  | OriGene Antibodies for RAB27A | | OriGene shRNA RFP for RAB27A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAB27A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAB27A | | | OriGene Protein Over-expression Lysate for RAB27A | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RAB27A | | OriGene 3'-UTR Clone for RAB27A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAB27A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAB27A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for RAB27A | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RAB27A | | OriGene Custom Protein Services for RAB27A | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RAB27A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAB27A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB27A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAB27A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAB27A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAB27A |
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| | | | Search Tocris compounds for RAB27A |
| |  |  |  |  | | | | | | Recombinant Protein for RAB27A |
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 | | | RAB27A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB27A |
|  |  |  |  | | | | Search ThermoFisher Antibodies for RAB27A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB27A |
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