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RAB26 Gene

protein-coding   GIFtS: 56

GC16P002138
RAB26, member RAS oncogene family
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
V46133 2
Descriptions
RAB26, member RAS oncogene family 2
Ras-related oncogene protein 2
External Ids
HGNC: 142591
Entrez Gene: 258372
UniProtKB: Q9ULW53
Ensembl: ENSG000001679647
Search outside databases for aliases for RAB26 gene

Previous GC identifer: GC16P002215

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: RAB26_HUMAN, Q9ULW5
Function: Participates in exocrine secretion: regulates the secretion of acinar granules in the
parotid gland (By similarity)

Gene Wiki entry for RAB26

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the RAB26 gene  

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

RAB26 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P002138:     (about GC identifiers)

Start:
2,138,646 bp from pter
End:
2,144,142 bp from pter
Size:
5,497 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000016.8  NT_037887.4  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: RAB26_HUMAN, Q9ULW5 (See protein sequence)
Recommended Name: Ras-related protein Rab-26  
Size: 256 amino acids; 27900 Da
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (By similarity)
PDB structures from and Proteopedia :
2G6B (3D)    
Secondary accessions: Q6NXS7

REFSEQ proteins: NP_055168.2  

ENSEMBL proteins: 
ENSP00000210187 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (RAB26)
Human Recombinant Proteins from Abnova (RAB26)
              OriGene Purified Recombinant Human Protein: RAB26 

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005575 cellular_component ND--
GO:0005886 plasma membrane IEA--
GO:0031226 intrinsic to plasma membrane ISS--
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Antibodies for RAB26: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for RAB26
Browse R&D Systems for Antibodies
Antibodies from Abcam (RAB26), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (RAB26)
Novus Biologicals Antibodies for RAB26

Assays for RAB26: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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4 InterPro domains/families:
 IPR001806 Ras_GTPase
 IPR005225 Small_GTP_bd
 IPR003579 GTPase_Rab
 IPR013753 Ras


   GeneDecks  RAB26 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q9ULW5

ProtoNet protein and cluster: Q9ULW5

1 Blocks protein family: IPB001806 Transforming protein P21 RAS signature

UniProtKB/Swiss-Prot: RAB26_HUMAN, Q9ULW5
Similarity: Belongs to the small GTPase superfamily. Rab family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (RAB26)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (RAB26)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014353

              Applied Biosystems Silencer® siRNAs for RAB26

              Sigma-Aldrich siRNA for RAB26  
                     Sigma-Aldrich shRNA for RAB26  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for RAB26
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_014353
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_014353
                                 untagged cDNA clone in CMV expression vector: NM_014353 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_014353

UniProtKB/Swiss-Prot: RAB26_HUMAN, Q9ULW5
Function: Participates in exocrine secretion: regulates the secretion of acinar granules in the
parotid gland (By similarity)

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0000166 nucleotide binding IEA--
GO:0005515 protein binding IPI16696853
GO:0005525 GTP binding NAS11043516
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


 Gene Network CentralTM Interacting Genes and Proteins Network for  RAB26 


2 Interacting proteins for RAB26 (ENSP000002101873 Q9ULW51) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
GCH1P307931EBI-958239, EBI-958183
CASKIN1ENSP000003454363STRING (score=.706)
About this table

5 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA--
GO:0008150 biological_process ND--
GO:0015031 protein transport IEA--
GO:0017157 regulation of exocytosis ISS--
GO:0035272 exocrine system development ISS--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for RAB26
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for RAB26

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (RAB26)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (RAB26)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014353

              Sigma-Aldrich siRNA for RAB26  
                     Sigma-Aldrich shRNA for RAB26  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_014353  

REFSEQ mRNAs for RAB26 gene: 

NM_014353.4   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_014353  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_014353
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_014353
                                 untagged cDNA clone in CMV expression vector: NM_014353 

Additional cDNA sequence: 

AB027137.1 AF498952.1 AK308560.1 AK309666.1 AK314110.1 AY646153.1 BC007681.2 BC066913.1 
CR598645.1 

7 DOTS entries:

DT.107062  DT.100778284  DT.95263381  DT.95263382  DT.100035948  DT.100690238  DT.120688259 

24/84 AceView cDNA sequences (see all 84 ):

CK826126 AW206417 CA943353 BE222260 AI871963 BQ688147 AF498952 BU076677 
AB027137 CR598645 NM_014353 BQ687186 AW088377 BC007681 AV692701 AV697216 
T08521 AV683344 BU076619 AL568072 BX464097 BM853818 BU196326 BM689146 

highest scoring ESTs for RAB26:

AI690165 AA573872 AA969796 AB027137 AF498952 AI348380 AI871963 AW088377 AW205643 AW206417 

Unigene Cluster for RAB26:

RAB26, member RAS oncogene family
Hs.3797  [show with all ESTs]
Unigene Representative Sequence: AK308560


GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for RAB26

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c
SP1:                                      -                                                               
SP2:                                      -                                                               
SP3:                                                                                                      
SP4:              -                       -                                                               
SP5:              -                                                                                       

About this scheme

ECgene alternative splicing isoforms for RAB26

1 Ensembl transcript including schematic representation:
ENST00000210187  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

RAB26 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for RAB26

1 / 2 / 3

5 probe-sets matching RAB26 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

50965_at2, 3 U133-B 1 1.00 1.00 1.00 1.00 AI690165 1.00 1.00 1.00 1

50965_at2, 3 U133-A 1 1.00 1.00 -- -- AI690165 1.00 1.00 1.00 1

219562_at2, 3 U133-A 1 1.00 1.00 -- -- NM_014353 0.60 1.00 0.82 1

50965_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

219562_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
About this table
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: CTCAGGCAGC

SOURCE GeneReport for Unigene cluster: Hs.3797

UniProtKB/Swiss-Prot: RAB26_HUMAN, Q9ULW5
Tissue specificity: Predominantly expressed in brain

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for RAB26 gene from 5/8 species (see all 8 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
RAB261   -- RAB26, member RAS oncogene family 90.3(n)
91.8(a)
610958  XM_848555.1  XP_853648.1 
chimpanzee
(Pan troglodytes)
RAB261   -- RAB26, member RAS oncogene family 99.82(n)
100(a)
453829  XM_510740.2  XP_510740.2 
cow
(Bos taurus)
RAB261   -- RAB26, member RAS oncogene family 87.11(n)
87.5(a)
515675  NM_001046209.1  NP_001039674.1 
rat
(Rattus norvegicus)
Rab261   -- RAB26, member RAS oncogene family 86.95(n)
93.65(a)
171111  NM_133580.1  NP_598264.1 
mouse
(Mus musculus)
Rab261, 5 175
RAB26, member RAS oncogene family1, 5 84.58(n)1
87.45(a)1
3287781  XM_283428.61  XP_283428.61 
 AB2326215  AI4132585  (see all 10)
About this table        Species with no ortholog for RAB26

ENSEMBL Gene Tree for RAB26
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for RAB26 gene
RAB27A2  RAB27B2  RAB372  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/22 NCBI SNPs in RAB26 are shown (see all 22 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 21)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 16 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs362311,2
A,C,F2138169(-) AAGCTG/CCAGCC 1 -- ng511Minor allele frequency- C:0.08MN 184
rs362301,2
C,H2136779(+) AGCCCG/ATTTCC 1 -- ng5110Minor allele frequency- A:0.00EU EA WA NA 720
rs269311,2
C,H2143457(+) AGCCGC/TCCAGT 1 -- ut31 ese38Minor allele frequency- T:0.04NA PA EU EA WA 682
rs362321,2
A,C,F,H2139789(+) AGGCAG/TACGCT 1 -- int14Minor allele frequency- T:0.18EU EA WA 416
rs362331,2
A,C,F,H2140883(+) GCTGAG/AGGAGG 1 -- int110Minor allele frequency- A:0.25EA NA EU WA 866
rs362341,2
A,C,F,H2141271(+) AGCTCG/CTTAGT 1 -- int18Minor allele frequency- C:0.40EA NA EU WA 558
--
rs16109021,2
F2140623(+) CTCCAGTCTGGGGAGCTG
TTCTCTACCCC
/-
GTCTG
1 -- int14Minor allele frequency- -:0.24EU NA EA 342
--
rs129180651,2
--2138415(+) GCCCAG/TGCCTG 1 -- ng510--------
--
rs352168381,2
--2137094(+) TCCCC-/CAGGGC 1 -- ng510--------
--
rs98068541,2
--2137001(+) TGGGGA/CCAGTG 1 -- ng510--------
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HapMap Linkage Disequilibrium images for RAB26 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 605455

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

8 PubMed articles for RAB26 gene:
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 25837 HGNC: 14259 AceView: RAB26 Ensembl:ENSG00000167964 euGenes: HUgn25837
ECgene: RAB26 H-InvDB: RAB26
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

NameDescription
ATLAS Chromosomes in Cancer entry for RAB26 Genetics and Cytogenetics in Oncology and Haematology
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for RAB26:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



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 Predesigned and custom siRNAs for RAB26 Antibodies for RAB26
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for RAB26 Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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 Tagged/untagged cDNA clones
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 Purified proteins from HEK293T cells
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 shRNA in GFP-retroviral vector
 Search Tocris compounds for RAB26




 Drugs for RAB26
 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for RAB26

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