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Aliases for RAB26 Gene

Aliases for RAB26 Gene

  • RAB26, Member RAS Oncogene Family 2 3
  • Ras-Related Oncogene Protein 3
  • V46133 3

External Ids for RAB26 Gene

Previous GeneCards Identifiers for RAB26 Gene

  • GC16P002215
  • GC16P002138
  • GC16P002198
  • GC16P002124
  • GC16P002190
  • GC16P002143

Summaries for RAB26 Gene

Entrez Gene Summary for RAB26 Gene

  • Members of the RAB protein family, including RAB26, are important regulators of vesicular fusion and trafficking. The RAB family of small G proteins regulates intercellular vesicle trafficking, including exocytosis, endocytosis, and recycling (summary by Seki et al., 2000 [PubMed 11043516]).[supplied by OMIM, Nov 2010]

GeneCards Summary for RAB26 Gene

RAB26 (RAB26, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include GTP binding and GMP binding. An important paralog of this gene is RAB37.

UniProtKB/Swiss-Prot for RAB26 Gene

  • The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Mediates transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. Plays a role in the maturation of zymogenic granules and in pepsinogen secretion in the stomach. Plays a role in the secretion of amylase from acinar granules in the parotid gland.

Gene Wiki entry for RAB26 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB26 Gene

Genomics for RAB26 Gene

Regulatory Elements for RAB26 Gene

Genomic Location for RAB26 Gene

Chromosome:
16
Start:
2,140,803 bp from pter
End:
2,154,165 bp from pter
Size:
13,363 bases
Orientation:
Plus strand

Genomic View for RAB26 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAB26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB26 Gene

Proteins for RAB26 Gene

  • Protein details for RAB26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULW5-RAB26_HUMAN
    Recommended name:
    Ras-related protein Rab-26
    Protein Accession:
    Q9ULW5
    Secondary Accessions:
    • B2RAA6
    • Q3L6K5
    • Q6NXS7

    Protein attributes for RAB26 Gene

    Size:
    256 amino acids
    Molecular mass:
    27900 Da
    Quaternary structure:
    • Interacts with RIMS1 (By similarity). Interacts with ADRA2B.
    SequenceCaution:
    • Sequence=BAA84707.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RAB26 Gene

    Alternative splice isoforms for RAB26 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAB26 Gene

Proteomics data for RAB26 Gene at MOPED

Post-translational modifications for RAB26 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB26 Gene

No data available for DME Specific Peptides for RAB26 Gene

Domains & Families for RAB26 Gene

Gene Families for RAB26 Gene

Graphical View of Domain Structure for InterPro Entry

Q9ULW5

UniProtKB/Swiss-Prot:

RAB26_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB26: view

Function for RAB26 Gene

Molecular function for RAB26 Gene

UniProtKB/Swiss-Prot Function:
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Mediates transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. Plays a role in the maturation of zymogenic granules and in pepsinogen secretion in the stomach. Plays a role in the secretion of amylase from acinar granules in the parotid gland.

Gene Ontology (GO) - Molecular Function for RAB26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IBA --
GO:0005515 protein binding IPI 23105096
GO:0005525 GTP binding ISS --
GO:0019002 GMP binding IMP 23105096
genes like me logo Genes that share ontologies with RAB26: view

Phenotypes for RAB26 Gene

GenomeRNAi human phenotypes for RAB26:
genes like me logo Genes that share phenotypes with RAB26: view

Animal Model Products

miRNA for RAB26 Gene

miRTarBase miRNAs that target RAB26

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAB26

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB26 Gene

Localization for RAB26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB26 Gene

Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle, secretory vesicle membrane; Lipid-anchor; Cytoplasmic side. Note=Not localized at the plasma membrane (By similarity). Inhibition of S-geranylgeranyl cysteine formation abolishes membrane location. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB26 Gene COMPARTMENTS Subcellular localization image for RAB26 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 4
endosome 3
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for RAB26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IDA 23105096
GO:0005622 intracellular --
GO:0005768 endosome IBA --
GO:0005886 plasma membrane IBA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with RAB26: view

Pathways & Interactions for RAB26 Gene

genes like me logo Genes that share pathways with RAB26: view

Pathways by source for RAB26 Gene

1 Qiagen pathway for RAB26 Gene

Gene Ontology (GO) - Biological Process for RAB26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport --
GO:0006904 vesicle docking involved in exocytosis IBA --
GO:0006913 nucleocytoplasmic transport --
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction --
genes like me logo Genes that share ontologies with RAB26: view

No data available for SIGNOR curated interactions for RAB26 Gene

Drugs & Compounds for RAB26 Gene

No Compound Related Data Available

Transcripts for RAB26 Gene

Unigene Clusters for RAB26 Gene

RAB26, member RAS oncogene family:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAB26

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB26 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c
SP1: -
SP2: -
SP3:
SP4: - -
SP5: -

Relevant External Links for RAB26 Gene

GeneLoc Exon Structure for
RAB26
ECgene alternative splicing isoforms for
RAB26

Expression for RAB26 Gene

mRNA expression in normal human tissues for RAB26 Gene

mRNA differential expression in normal tissues according to GTEx for RAB26 Gene

This gene is overexpressed in Brain - Cerebellum (x8.7) and Brain - Cerebellar Hemisphere (x8.5).

Protein differential expression in normal tissues from HIPED for RAB26 Gene

This gene is overexpressed in Breast (65.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RAB26 Gene



SOURCE GeneReport for Unigene cluster for RAB26 Gene Hs.3797

mRNA Expression by UniProt/SwissProt for RAB26 Gene

Q9ULW5-RAB26_HUMAN
Tissue specificity: Predominantly expressed in brain
genes like me logo Genes that share expression patterns with RAB26: view

Protein tissue co-expression partners for RAB26 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for RAB26 Gene

Orthologs for RAB26 Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB26 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RAB26 35
  • 87.11 (n)
  • 87.5 (a)
RAB26 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAB26 35
  • 88.11 (n)
  • 89.34 (a)
RAB26 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rab26 35
  • 84.58 (n)
  • 87.45 (a)
Rab26 16
Rab26 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rab26 35
  • 86.95 (n)
  • 93.65 (a)
oppossum
(Monodelphis domestica)
Mammalia RAB26 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAB26 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RAB26 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAB26 35
  • 79.15 (n)
  • 84.93 (a)
RAB26 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAB26 36
  • 83 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii rab15 36
  • 42 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7605 37
  • 63 (a)
Rab26 35
  • 67.01 (n)
  • 64.47 (a)
Rab26 36
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rab-37 36
  • 49 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 58 (a)
OneToMany
Species with no ortholog for RAB26:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RAB26 Gene

ENSEMBL:
Gene Tree for RAB26 (if available)
TreeFam:
Gene Tree for RAB26 (if available)

Paralogs for RAB26 Gene

Paralogs for RAB26 Gene

genes like me logo Genes that share paralogs with RAB26: view

Variants for RAB26 Gene

Sequence variations from dbSNP and Humsavar for RAB26 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs26931 -- 2,153,455(+) AGCCG(A/C/T)CCAGT utr-variant-3-prime
rs35786 -- 2,146,338(+) acagg(C/T)gtatg upstream-variant-2KB
rs36230 -- 2,146,777(+) AGCCC(A/G)TTTCC upstream-variant-2KB
rs36231 -- 2,148,167(-) AAGCT(C/G)CAGCC upstream-variant-2KB, utr-variant-5-prime
rs36232 -- 2,149,787(+) AGGCA(G/T)ACGCT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RAB26 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
dgv2540n71 CNV Loss 21882294
dgv2544n71 CNV Loss 21882294
dgv2545n71 CNV Loss 21882294
dgv2546n71 CNV Loss 21882294
dgv2549n71 CNV Loss 21882294
dgv2550n71 CNV Loss 21882294
nsv471072 CNV Loss 18288195
dgv2556n71 CNV Loss 21882294
dgv2557n71 CNV Loss 21882294
nsv457349 CNV Loss 19166990
dgv2558n71 CNV Loss 21882294
dgv2562n71 CNV Loss 21882294
dgv2563n71 CNV Loss 21882294
nsv905127 CNV Loss 21882294
dgv2564n71 CNV Loss 21882294
nsv905131 CNV Loss 21882294

Variation tolerance for RAB26 Gene

Residual Variation Intolerance Score: 77.75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.92; 19.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAB26 Gene

HapMap Linkage Disequilibrium report
RAB26

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB26 Gene

Disorders for RAB26 Gene

Relevant External Links for RAB26

Genetic Association Database (GAD)
RAB26
Human Genome Epidemiology (HuGE) Navigator
RAB26
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAB26
genes like me logo Genes that share disorders with RAB26: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB26 Gene

Publications for RAB26 Gene

  1. cDNA cloning of a human RAB26-related gene encoding a Ras-like GTP- binding protein on chromosome 16p13.3 region. (PMID: 11043516) Seki N. … Saito T. (J. Hum. Genet. 2000) 2 67
  2. The GTPase Rab26 links synaptic vesicles to the autophagy pathway. (PMID: 25643395) Binotti B. … Jahn R. (Elife 2015) 67
  3. RAB26 coordinates lysosome traffic and mitochondrial localization. (PMID: 24413166) Jin R.U. … Mills J.C. (J. Cell. Sci. 2014) 67
  4. Rab26 modulates the cell surface transport of alpha2-adrenergic receptors from the Golgi. (PMID: 23105096) Li C. … Wu G. (J. Biol. Chem. 2012) 67
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 67

Products for RAB26 Gene

Sources for RAB26 Gene

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