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Aliases for RAB25 Gene

Aliases for RAB25 Gene

  • RAB25, Member RAS Oncogene Family 2 3
  • RAB11C 3 6
  • CATX-8 3 4
  • Ras-Related Protein Rab-25 3
  • CATX8 4

External Ids for RAB25 Gene

Summaries for RAB25 Gene

Entrez Gene Summary for RAB25 Gene

  • RAB proteins, such as RAB25, are members of the RAS superfamily of small GTPases that are involved in membrane trafficking. Members of the RAB11 subfamily, including RAB25, control the return of internalized membrane-associated moieties to the cell surface (Caswell et al., 2007 [PubMed 17925226]).[supplied by OMIM, Aug 2009]

GeneCards Summary for RAB25 Gene

RAB25 (RAB25, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Cytoskeletal Signaling and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include GTP binding. An important paralog of this gene is RAB42.

UniProtKB/Swiss-Prot for RAB25 Gene

  • Involved in the regulation of cell survival. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia (PubMed:17925226). Involved in the regulation of epithelial morphogenesis through the control of CLDN4 expression and localization at tight junctions (By similarity). May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis (By similarity).

Gene Wiki entry for RAB25 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB25 Gene

Genomics for RAB25 Gene

Genomic Location for RAB25 Gene

Start:
156,061,160 bp from pter
End:
156,070,514 bp from pter
Size:
9,355 bases
Orientation:
Plus strand

Genomic View for RAB25 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAB25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB25 Gene

Regulatory Elements for RAB25 Gene

Proteins for RAB25 Gene

  • Protein details for RAB25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P57735-RAB25_HUMAN
    Recommended name:
    Ras-related protein Rab-25
    Protein Accession:
    P57735
    Secondary Accessions:
    • Q5VYA2
    • Q8NG24
    • Q96GB1
    • Q9BT12

    Protein attributes for RAB25 Gene

    Size:
    213 amino acids
    Molecular mass:
    23496 Da
    Quaternary structure:
    • Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 and RAB11FIP4. Interacts (via the hypervariable C-terminal region) with ITGB1 (via the cytoplasmic region); the interaction is GTP-dependent. Interacts with ITGAV. Associates with the integrin alpha-V/beta-1 heterodimer.
    SequenceCaution:
    • Sequence=AAF98238.1; Type=Frameshift; Positions=196; Evidence={ECO:0000305}; Sequence=AAM69362.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RAB25 Gene

neXtProt entry for RAB25 Gene

Proteomics data for RAB25 Gene at MOPED

Post-translational modifications for RAB25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB25 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RAB25 Gene

Domains for RAB25 Gene

Gene Families for RAB25 Gene

HGNC:
  • RAB :RAB, member RAS oncogene

UniProtKB/Swiss-Prot:

RAB25_HUMAN
Family:
  • Belongs to the small GTPase superfamily. Rab family.:
    • P57735
genes like me logo Genes that share domains with RAB25: view

Function for RAB25 Gene

Molecular function for RAB25 Gene

UniProtKB/Swiss-Prot Function: Involved in the regulation of cell survival. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia (PubMed:17925226). Involved in the regulation of epithelial morphogenesis through the control of CLDN4 expression and localization at tight junctions (By similarity). May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis (By similarity).

Gene Ontology (GO) - Molecular Function for RAB25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IBA --
GO:0005515 protein binding IPI 17925226
GO:0005525 GTP binding IEA --
GO:0031489 myosin V binding IPI 24006491
genes like me logo Genes that share ontologies with RAB25: view

Phenotypes for RAB25 Gene

genes like me logo Genes that share phenotypes with RAB25: view

Animal Models for RAB25 Gene

MGI Knock Outs for RAB25:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for RAB25 Gene

Localization for RAB25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB25 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Cell projection, pseudopodium membrane. Cytoplasmic vesicle. Note=Colocalizes with integrin alpha-V/beta-1 in vesicles at the pseudopodial tips. {ECO:0000269 PubMed:17925226}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB25 Gene COMPARTMENTS Subcellular localization image for RAB25 gene
Compartment Confidence
plasma membrane 5
cytosol 3
cytoskeleton 2
endosome 2
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RAB25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005737 cytoplasm --
GO:0005886 plasma membrane --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with RAB25: view

Pathways for RAB25 Gene

genes like me logo Genes that share pathways with RAB25: view

Pathways by source for RAB25 Gene

1 Qiagen pathway for RAB25 Gene
1 Cell Signaling Technology pathway for RAB25 Gene

Gene Ontology (GO) - Biological Process for RAB25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003382 epithelial cell morphogenesis ISS --
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport IBA --
GO:0006887 exocytosis IBA --
GO:0006913 nucleocytoplasmic transport --
genes like me logo Genes that share ontologies with RAB25: view

Compounds for RAB25 Gene

(1) Novoseek inferred chemical compound relationships for RAB25 Gene

Compound -log(P) Hits PubMed IDs
gtp 38.1 2
genes like me logo Genes that share compounds with RAB25: view

Transcripts for RAB25 Gene

Unigene Clusters for RAB25 Gene

RAB25, member RAS oncogene family:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAB25 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b
SP1: - - -
SP2: - - - - -
SP3: -
SP4: - - - -
SP5: - - -
SP6:

Relevant External Links for RAB25 Gene

GeneLoc Exon Structure for
RAB25
ECgene alternative splicing isoforms for
RAB25

Expression for RAB25 Gene

mRNA expression in normal human tissues for RAB25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB25 Gene

This gene is overexpressed in Esophagus - Mucosa (13.4), Skin - Sun Exposed (Lower leg) (6.2), Skin - Not Sun Exposed (Suprapubic) (5.7), and Vagina (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB25 Gene

SOURCE GeneReport for Unigene cluster for RAB25 Gene Hs.632469

mRNA Expression by UniProt/SwissProt for RAB25 Gene

P57735-RAB25_HUMAN
Tissue specificity: Expressed in ovarian epithelium (NOE) and breast tissue. Expressed in ovarian cancer; expression is increased relative to NOE cells. Expression in ovarian cancer is stage dependent, with stage III and stage IV showing higher levels than early stage cancers. Expressed in breast cancer; expression is increased relative to normal breast tissue.
genes like me logo Genes that share expressions with RAB25: view

Orthologs for RAB25 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAB25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB25 36
  • 99.84 (n)
  • 100 (a)
RAB25 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RAB25 36
  • 91.39 (n)
  • 95.31 (a)
RAB25 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAB25 36
  • 88.58 (n)
  • 96.24 (a)
RAB25 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rab25 36
  • 90.61 (n)
  • 95.77 (a)
Rab25 16
Rab25 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAB25 37
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rab25 36
  • 90.45 (n)
  • 96.71 (a)
chicken
(Gallus gallus)
Aves RAB25 36
  • 73.56 (n)
  • 83.24 (a)
RAB25 37
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rab25 36
  • 69.13 (n)
  • 71.43 (a)
Str.10328 36
zebrafish
(Danio rerio)
Actinopterygii rab25a 36
  • 66.83 (n)
  • 71.78 (a)
rab25a 37
  • 68 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Rab11 37
  • 58 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rab-11.1 37
  • 59 (a)
ManyToMany
rab-11.2 37
  • 56 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPT31 37
  • 49 (a)
ManyToMany
YPT32 37
  • 49 (a)
ManyToMany
Species with no ortholog for RAB25:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB25 Gene

ENSEMBL:
Gene Tree for RAB25 (if available)
TreeFam:
Gene Tree for RAB25 (if available)

Paralogs for RAB25 Gene

genes like me logo Genes that share paralogs with RAB25: view

Variants for RAB25 Gene

Sequence variations from dbSNP and Humsavar for RAB25 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1056666 -- 156,070,284(+) AGCCT(C/T)TGACC reference, synonymous-codon
rs2275073 -- 156,061,029(+) CCCCC(A/C)GCTGG upstream-variant-2KB
rs2275074 -- 156,068,301(+) TCCTG(A/G)TGTTT missense, reference
rs2275075 -- 156,070,519(+) ATTCC(A/G)CTGCC downstream-variant-500B
rs4661145 -- 156,066,766(+) AAATC(C/T)TGTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB25 Gene

Variant ID Type Subtype PubMed ID
nsv509513 CNV Insertion 20534489

Relevant External Links for RAB25 Gene

HapMap Linkage Disequilibrium report
RAB25

Disorders for RAB25 Gene

Relevant External Links for RAB25

Genetic Association Database (GAD)
RAB25
genes like me logo Genes that share disorders with RAB25: view

No data available for UniProtKB/Swiss-Prot for RAB25 Gene

Publications for RAB25 Gene

  1. Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments. (PMID: 17925226) Caswell P.T. … Norman J.C. (Dev. Cell 2007) 3 4 23
  2. Identification of a small GTP-binding protein, Rab25, expressed in the gastrointestinal mucosa, kidney, and lung. (PMID: 8360141) Goldenring J.R. … Modlin I.M. (J. Biol. Chem. 1993) 3 23
  3. Increased immunoreactivity for Rab11, a small GTP-binding protein, in low-grade dysplastic Barrett's epithelia. (PMID: 9389793) Ray G.S. … Goldenring J.R. (Lab. Invest. 1997) 3 23
  4. Tumor suppressor function of Rab25 in triple-negative breast cancer. (PMID: 19795443) Cheng J.M. … Rao K.A. (Int. J. Cancer 2010) 3 23
  5. Loss of Rab25 promotes the development of intestinal neoplasia in mice and is associated with human colorectal adenocarcinomas. (PMID: 20197623) Nam K.T. … Goldenring J.R. (J. Clin. Invest. 2010) 3 23

Products for RAB25 Gene

  • Addgene plasmids for RAB25

Sources for RAB25 Gene

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