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Aliases for RAB25 Gene

Aliases for RAB25 Gene

  • RAB25, Member RAS Oncogene Family 2 3 5
  • CATX-8 3 4
  • Ras-Related Protein Rab-25 3
  • RAB11C 3
  • CATX8 4

External Ids for RAB25 Gene

Previous GeneCards Identifiers for RAB25 Gene

  • GC01P153899
  • GC01P151796
  • GC01P152809
  • GC01P153247
  • GC01P152844
  • GC01P154297
  • GC01P156030
  • GC01P127393

Summaries for RAB25 Gene

Entrez Gene Summary for RAB25 Gene

  • The protein encoded by this gene is a member of the RAS superfamily of small GTPases. The encoded protein is involved in membrane trafficking and cell survival. This gene has been found to be a tumor suppressor and an oncogene, depending on the context. Two variants, one protein-coding and the other not, have been found for this gene. [provided by RefSeq, Nov 2015]

GeneCards Summary for RAB25 Gene

RAB25 (RAB25, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are RAB geranylgeranylation and Metabolism of proteins. GO annotations related to this gene include GTP binding and myosin V binding. An important paralog of this gene is RAB11B.

UniProtKB/Swiss-Prot for RAB25 Gene

  • Involved in the regulation of cell survival. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia (PubMed:17925226). Involved in the regulation of epithelial morphogenesis through the control of CLDN4 expression and localization at tight junctions (By similarity). May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis (By similarity).

Gene Wiki entry for RAB25 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB25 Gene

Genomics for RAB25 Gene

Regulatory Elements for RAB25 Gene

Enhancers for RAB25 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G156060 0.8 ENCODE 0.7 +0.5 525 2.4 NFIB SIN3A RAD21 ETS1 ZNF121 SCRT2 SMARCA5 ZNF263 ELF1 ZNF579 GBA RAB25 PIR47543
GH01G156063 0.6 ENCODE 0.7 +2.4 2405 0.2 STAT1 ESRRA KLF1 CEBPB CEBPG RARA CEBPA SMAD4 NR2F6 RAB25 PIR47543
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RAB25 on UCSC Golden Path with GeneCards custom track

Promoters for RAB25 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000014137 340 201 MAZ NFIB ZMYM3 ELF1 RBBP5 CHD7 ETS1 ZNF121 HDAC2 POLR2A

Genomic Location for RAB25 Gene

Chromosome:
1
Start:
156,061,160 bp from pter
End:
156,070,514 bp from pter
Size:
9,355 bases
Orientation:
Plus strand

Genomic View for RAB25 Gene

Genes around RAB25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB25 Gene

Proteins for RAB25 Gene

  • Protein details for RAB25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P57735-RAB25_HUMAN
    Recommended name:
    Ras-related protein Rab-25
    Protein Accession:
    P57735
    Secondary Accessions:
    • Q5VYA2
    • Q8NG24
    • Q96GB1
    • Q9BT12

    Protein attributes for RAB25 Gene

    Size:
    213 amino acids
    Molecular mass:
    23496 Da
    Quaternary structure:
    • Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 and RAB11FIP4. Interacts (via the hypervariable C-terminal region) with ITGB1 (via the cytoplasmic region); the interaction is GTP-dependent. Interacts with ITGAV. Associates with the integrin alpha-V/beta-1 heterodimer.
    SequenceCaution:
    • Sequence=AAF98238.1; Type=Frameshift; Positions=196; Evidence={ECO:0000305}; Sequence=AAM69362.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RAB25 Gene

neXtProt entry for RAB25 Gene

Post-translational modifications for RAB25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB25 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RAB25 (RAB25)

No data available for DME Specific Peptides for RAB25 Gene

Domains & Families for RAB25 Gene

Gene Families for RAB25 Gene

Suggested Antigen Peptide Sequences for RAB25 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P57735

UniProtKB/Swiss-Prot:

RAB25_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB25: view

Function for RAB25 Gene

Molecular function for RAB25 Gene

UniProtKB/Swiss-Prot Function:
Involved in the regulation of cell survival. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia (PubMed:17925226). Involved in the regulation of epithelial morphogenesis through the control of CLDN4 expression and localization at tight junctions (By similarity). May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis (By similarity).

Gene Ontology (GO) - Molecular Function for RAB25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005515 protein binding IPI 17925226
GO:0005525 GTP binding IEA --
GO:0031489 myosin V binding IPI 24006491
genes like me logo Genes that share ontologies with RAB25: view
genes like me logo Genes that share phenotypes with RAB25: view

Animal Models for RAB25 Gene

MGI Knock Outs for RAB25:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RAB25

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RAB25 Gene

Localization for RAB25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB25 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Cell projection, pseudopodium membrane. Cytoplasmic vesicle. Note=Colocalizes with integrin alpha-V/beta-1 in vesicles at the pseudopodial tips. {ECO:0000269 PubMed:17925226}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB25 gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytosol 4
cytoskeleton 2
endosome 2
mitochondrion 1
nucleus 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for RAB25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0031143 pseudopodium IDA 17925226
GO:0031260 pseudopodium membrane IEA --
GO:0031410 cytoplasmic vesicle IEA,IDA 17925226
genes like me logo Genes that share ontologies with RAB25: view

Pathways & Interactions for RAB25 Gene

genes like me logo Genes that share pathways with RAB25: view

Pathways by source for RAB25 Gene

1 Cell Signaling Technology pathway for RAB25 Gene
1 Qiagen pathway for RAB25 Gene

Gene Ontology (GO) - Biological Process for RAB25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003382 epithelial cell morphogenesis ISS,IEA --
GO:0006810 transport IEA --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0008284 positive regulation of cell proliferation IDA 15502842
GO:0010634 positive regulation of epithelial cell migration IMP 22613965
genes like me logo Genes that share ontologies with RAB25: view

No data available for SIGNOR curated interactions for RAB25 Gene

Drugs & Compounds for RAB25 Gene

(1) Additional Compounds for RAB25 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RAB25: view

Transcripts for RAB25 Gene

Unigene Clusters for RAB25 Gene

RAB25, member RAS oncogene family:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RAB25

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB25 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b
SP1: - - -
SP2: - - - - -
SP3: -
SP4: - - - -
SP5: - - -
SP6:

Relevant External Links for RAB25 Gene

GeneLoc Exon Structure for
RAB25
ECgene alternative splicing isoforms for
RAB25

Expression for RAB25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAB25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB25 Gene

This gene is overexpressed in Esophagus - Mucosa (x13.4), Skin - Sun Exposed (Lower leg) (x6.2), Skin - Not Sun Exposed (Suprapubic) (x5.7), and Vagina (x4.1).

Protein differential expression in normal tissues from HIPED for RAB25 Gene

This gene is overexpressed in Nasal epithelium (21.1) and Cervix (16.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RAB25 Gene



Protein tissue co-expression partners for RAB25 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RAB25 Gene:

RAB25

SOURCE GeneReport for Unigene cluster for RAB25 Gene:

Hs.632469

mRNA Expression by UniProt/SwissProt for RAB25 Gene:

P57735-RAB25_HUMAN
Tissue specificity: Expressed in ovarian epithelium (NOE) and breast tissue. Expressed in ovarian cancer; expression is increased relative to NOE cells. Expression in ovarian cancer is stage dependent, with stage III and stage IV showing higher levels than early stage cancers. Expressed in breast cancer; expression is increased relative to normal breast tissue.

Evidence on tissue expression from TISSUES for RAB25 Gene

  • Intestine(4.5)
  • Skin(4.4)
  • Pancreas(4.2)
  • Stomach(2.4)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with RAB25: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RAB25 Gene

Orthologs for RAB25 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAB25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB25 34 35
  • 99.84 (n)
oppossum
(Monodelphis domestica)
Mammalia RAB25 35
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RAB25 34 35
  • 91.39 (n)
mouse
(Mus musculus)
Mammalia Rab25 34 16 35
  • 90.61 (n)
rat
(Rattus norvegicus)
Mammalia Rab25 34
  • 90.45 (n)
dog
(Canis familiaris)
Mammalia RAB25 34 35
  • 88.58 (n)
chicken
(Gallus gallus)
Aves RAB25 34 35
  • 73.56 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia rab25 34
  • 69.13 (n)
Str.10328 34
zebrafish
(Danio rerio)
Actinopterygii rab25a 34 35
  • 66.83 (n)
fruit fly
(Drosophila melanogaster)
Insecta Rab11 35
  • 58 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rab-11.1 35
  • 59 (a)
ManyToMany
rab-11.2 35
  • 56 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPT31 35
  • 49 (a)
ManyToMany
YPT32 35
  • 49 (a)
ManyToMany
Species where no ortholog for RAB25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB25 Gene

ENSEMBL:
Gene Tree for RAB25 (if available)
TreeFam:
Gene Tree for RAB25 (if available)

Paralogs for RAB25 Gene

Variants for RAB25 Gene

Sequence variations from dbSNP and Humsavar for RAB25 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000194146 -- 156,065,920(+) GCTGA(C/T)CGGCG intron-variant, reference, missense
rs1000194662 -- 156,066,252(+) TAAAA(C/G)GTACT intron-variant
rs1000225706 -- 156,066,657(+) TCTTA(A/G)GCCGG intron-variant
rs1000635740 -- 156,059,162(+) ACTTC(A/C/G)ACTGG upstream-variant-2KB
rs1001200511 -- 156,064,923(+) TGCTT(A/C)GTTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB25 Gene

Variant ID Type Subtype PubMed ID
nsv509513 CNV insertion 20534489

Variation tolerance for RAB25 Gene

Residual Variation Intolerance Score: 74.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.18; 39.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAB25 Gene

Human Gene Mutation Database (HGMD)
RAB25
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAB25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB25 Gene

Disorders for RAB25 Gene

Relevant External Links for RAB25

Genetic Association Database (GAD)
RAB25
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAB25

No disorders were found for RAB25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB25 Gene

Publications for RAB25 Gene

  1. Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments. (PMID: 17925226) Caswell P.T. … Norman J.C. (Dev. Cell 2007) 3 4 22 64
  2. Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. (PMID: 21292315) . … Wood N.W. (Lancet 2011) 3 46 64
  3. Tumor suppressor function of Rab25 in triple-negative breast cancer. (PMID: 19795443) Cheng J.M. … Rao K.A. (Int. J. Cancer 2010) 3 22 64
  4. Loss of Rab25 promotes the development of intestinal neoplasia in mice and is associated with human colorectal adenocarcinomas. (PMID: 20197623) Nam K.T. … Goldenring J.R. (J. Clin. Invest. 2010) 3 22 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for RAB25 Gene

Sources for RAB25 Gene

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