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Aliases & Descriptions for RAB25
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| CATX-8 1, 2, 3 | | CATX8 3 | | OTTHUMP00000018847 2 |
| | | Descriptions |
|---|
| RAB25, member RAS oncogene family 2 |
|
| | Search outside databases for aliases for RAB25 genePrevious GC identifers: GC01P153899 GC01P151796 GC01P152809 GC01P153247 GC01P152844 |
Summaries for RAB25(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: RAB25_HUMAN, P57735Function: May selectively regulate the apical recycling and/or transcytotic pathways (By similarity)Gene Wiki entry for RAB25 |
Genomic Location for RAB25
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the RAB25 gene 
Entrez Gene cytogenetic band: 1q22 Ensembl cytogenetic band: 1q22 HGNC cytogenetic band: 1q22RAB25 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P154297:
(about GC identifiers)
Start:
|
154,297,590 bp from pter |
End:
|
154,306,919 bp from pter |
Size:
|
9,330 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000001.9 NT_004487.18
| Proteins for RAB25
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: RAB25_HUMAN, P57735 (See
protein sequence)Recommended Name: Ras-related protein Rab-25 Size: 213 amino acids; 23496 Da
Subunit: Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 and RAB11FIP4
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
Sequence caution: Sequence=AAF98238.1; Type=Frameshift; Positions=196;
PDB structures from and Proteopedia :2OIL (3D)
 
Secondary accessions: Q5VYA2 Q8NG24 Q96GB1 Q9BT12REFSEQ proteins: NP_065120.2
ENSEMBL proteins: ENSP00000354376
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for RAB25: Assays for RAB25: | Protein
Domains/ Families for RAB25(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P57735
ProtoNet protein and cluster: P57735 4 Blocks protein families: IPB001806 Transforming protein P21 RAS signature IPB002041 GTP-binding nuclear protein Ran IPB003577 Ras small GTPase IPB003578 Ras small GTPase
UniProtKB/Swiss-Prot: RAB25_HUMAN, P57735Similarity: Belongs to the small GTPase superfamily. Rab family | Gene Function for RAB25
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_020387
Applied Biosystems Silencer® siRNAs for RAB25
Sigma-Aldrich siRNA for RAB25  Sigma-Aldrich shRNA for RAB25  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_020387                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_020387                                  untagged cDNA clones in CMV expression vector (see all 2): NM_020387 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_020387
UniProtKB/Swiss-Prot: RAB25_HUMAN, P57735Function: May selectively regulate the apical recycling and/or transcytotic pathways (By similarity)3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for RAB25
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for RAB25 
3 Interacting proteins for RAB25 (P577351) via UniProtKB, MINT, and/or STRINGAbout this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007264 | small GTPase mediated signal transduction |
IEA | -- | | GO:0015031 | protein transport |
IEA | -- | About this table
|
Drugs & Compounds for RAB25(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|  |
Enzo Life Sciences drugs & compounds for RAB25 |
Browse Tocris compounds for RAB25 1 Novoseek chemical compound relationship for RAB25 gene
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| gtp |
44.85 |
2 |
8360141 (2) |
About this table
|
Transcripts for RAB25(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_020387
Sigma-Aldrich siRNA for RAB25  Sigma-Aldrich shRNA for RAB25  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_020387 REFSEQ mRNAs for RAB25 gene: NM_020387.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_020387               OriGene GFP tagged cDNA clone in CMV expression vector: NM_020387                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_020387                                  untagged cDNA clones in CMV expression vector (see all 2): NM_020387  Additional cDNA sequence: AF083124.1 AF274025.1 BC004416.1 BC009831.2 BC033322.1 CR599507.1 10 DOTS entries: DT.317133 DT.86842442 DT.100792538 DT.97846953 DT.121330569 DT.92437040 DT.100792540 DT.97846954 DT.100792542 DT.121330629 24/198 AceView cDNA sequences (see all 198
):AI246699 CB128282 BM672100 BC004416 AL545490 BG682384 BM833326 BE718362 BM762058 CA489548 BE745389 BE742686 BM834846 BQ933120 CB306287 BG680066 BE272246 BM811535 CB160385 BM824143 BG292330 BM987996 BC009831 AA337947
highest scoring ESTs for RAB25:AA195079 AA130429 AA218694 AA403293 AA463354 AA463366 AA463861 AA463870 AA480665 AA507859 Unigene Cluster for RAB25: RAB25, member RAS oncogene family Hs.632469 [show with all ESTs]Unigene Representative Sequence: BE612887
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for RAB25 (see all 6
)
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | |
| SP1: | |   | |   | |   | |   | - |   | - |   | |   | |   | - |   | |   | |   | |
| SP2: | |   | |   | - |   | - |   | - |   | - |   | |   | |   | - |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |
| SP4: | |   | |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for RAB25
1 Ensembl transcript including schematic representation: ENST00000361084
|
Expression for RAB25
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| RAB25 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for RAB25
1 / 2 / 3 3 probe-sets matching RAB25 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: CCCTATCACA
SOURCE GeneReport for Unigene cluster: Hs.632469
|
Orthologs for RAB25
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for RAB25 gene from 5/9 species (see all 9
)
About this table Species with no ortholog for RAB25
ENSEMBL Gene Tree for RAB25 | Paralogs for RAB25(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for RAB25 gene
- RAB352 RAB11A2 RAB11B2
|
SNPs/Variants for RAB25(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for RAB25 (up to first 250kb)
|
Disorders & Mutations for RAB25
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
| -- |
Medical News for RAB25(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for RAB25 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/20 PubMed articles for RAB25 gene (see all 20
):- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Identification and characterization of a family of Rab11-interacting proteins. (PubMed id 11495908)3, 4 Hales C.M....Goldenring J.R. (2001)
- Evolution of the Rab family of small GTP-binding proteins. (PubMed id 11697911)2, 3 Pereira-Leal J.B. and Seabra M.C. (2001)
- Identification of a small GTP-binding protein, Rab25, expressed in the gastrointestinal mucosa, kidney, and lung. (PubMed id 8360141)1, 3 Goldenring J.R....Modlin I.M. (1993)
- Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments. (PubMed id 17925226)1, 3 Caswell P.T....Norman J.C. (2007)
- Increased immunoreactivity for Rab11, a small GTP-binding protein, in low-grade dysplastic Barrett's epithelia. (PubMed id 9389793)1, 3 Ray G.S....Goldenring J.R. (1997)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)3 Barbe L....Andersson-Svahn H. (2008)
- Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)3 Ewing R.M....Figeys D. (2007)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)4 Gregory S.G.... Bentley D.R. (2006)
- Knockdown of RAB25 expression by RNAi inhibits growth of human epithelial ovarian cancer cells in vitro and in vivo. (PubMed id 17393986)3 Fan Y....Ma X. (2006)
|
Search for RAB25
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing RAB25
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing RAB25
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RAB25(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for RAB25(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for RAB25:

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Incremental update: 13 Oct 2009
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