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RAB25 Gene

protein-coding   GIFtS: 57
GCID: GC01P156030

RAB25, Member RAS Oncogene Family

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RAB25, Member RAS Oncogene Family1 2
CATX-82 3
RAB11C2 5
Ras-Related Protein Rab-252
CATX83

External Ids:    HGNC: 182381   Entrez Gene: 571112   Ensembl: ENSG000001326987   OMIM: 6129425   UniProtKB: P577353   

Export aliases for RAB25 gene to outside databases

Previous GC identifers: GC01P153899 GC01P151796 GC01P152809 GC01P153247 GC01P152844 GC01P154297 GC01P127393


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RAB25 Gene:
RAB proteins, such as RAB25, are members of the RAS superfamily of small GTPases that are involved in membrane
trafficking. Members of the RAB11 subfamily, including RAB25, control the return of internalized
membrane-associated moieties to the cell surface (Caswell et al., 2007 (PubMed 17925226)).(supplied by OMIM, Aug
2009)

GeneCards Summary for RAB25 Gene:
RAB25 (RAB25, member RAS oncogene family) is a protein-coding gene. GO annotations related to this gene include GTP binding. An important paralog of this gene is RAB19.

UniProtKB/Swiss-Prot: RAB25_HUMAN, P57735
Function: Involved in the regulation of cell survival. Promotes invasive migration of cells in which it functions
to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia. Increases the rates of
ovarian and breast cancers progression and aggressiveness by modulating cellular processes such as proliferation,
survival and migration of epithelial tumor cells. May selectively regulate the apical recycling pathway. Together
with MYO5B regulates transcytosis (By similarity)

Gene Wiki entry for RAB25 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the RAB25 gene promoter:
         Pax-5   RelA   MIF-1   NF-kappaB   Tal-1beta   GATA-1   HEN1   Sox9   ITF-2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRAB25 promoter sequence
   Search Chromatin IP Primers for RAB25

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RAB25


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q22   Ensembl cytogenetic band:  1q22   HGNC cytogenetic band: 1q22

RAB25 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAB25 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P156030:  view genomic region     (about GC identifiers)

Start:
156,030,951 bp from pter      End:
156,040,295 bp from pter
Size:
9,345 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RAB25_HUMAN, P57735 (See protein sequence)
Recommended Name: Ras-related protein Rab-25 precursor  
Size: 213 amino acids; 23496 Da
Subunit: Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 and RAB11FIP4. Interacts (via the hypervariable C-terminal
region) with ITGB1 (via the cytoplasmic region); the interaction is GTP-dependent. Interacts with ITGAV.
Associates with the integrin alpha-V/beta-1 heterodimer
Sequence caution: Sequence=AAF98238.1; Type=Frameshift; Positions=196; Sequence=AAM69362.1; Type=Erroneous
initiation; Note=Translation N-terminally shortened;
2 PDB 3D structures from and Proteopedia for RAB25:
2OIL (3D)        3TSO (3D)    
Secondary accessions: Q5VYA2 Q8NG24 Q96GB1 Q9BT12

Explore the universe of human proteins at neXtProt for RAB25: NX_P57735

Explore proteomics data for RAB25 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RAB25 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065120.2  
    ENSEMBL proteins: 
     ENSP00000354376  

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    antibodies-online proteins for RAB25 (9 products) 

     
    antibodies-online peptides for RAB25

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RAB: RAB, member RAS oncogene

    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR003579 Small_GTPase_Rab_type
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry P57735

    ProtoNet protein and cluster: P57735

    4 Blocks protein domains:
    IPB001806 Transforming protein P21 RAS signature
    IPB002041 GTP-binding nuclear protein Ran
    IPB003577 Ras small GTPase
    IPB003578 Ras small GTPase


    UniProtKB/Swiss-Prot: RAB25_HUMAN, P57735
    Similarity: Belongs to the small GTPase superfamily. Rab family


    Find genes that share domains with RAB25           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RAB25_HUMAN, P57735
    Function: Involved in the regulation of cell survival. Promotes invasive migration of cells in which it functions
    to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia. Increases the rates of
    ovarian and breast cancers progression and aggressiveness by modulating cellular processes such as proliferation,
    survival and migration of epithelial tumor cells. May selectively regulate the apical recycling pathway. Together
    with MYO5B regulates transcytosis (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity ----
    GO:0005515protein binding IPI17925226
    GO:0005525GTP binding IEA--
         
    Find genes that share ontologies with RAB25           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for RAB25:
     Increased G1 DNA content 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rab25):
     digestive/alimentary  reproductive system  tumorigenesis 

    Find genes that share phenotypes with RAB25           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Rab25tm1Jrgo for RAB25

       genOway: Develop your customized and physiologically relevant rodent model for RAB25

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RAB25_HUMAN, P57735: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Cell projection, pseudopodium
    membrane. Cytoplasmic vesicle. Note=Colocalizes with integrin alpha-V/beta-1 in vesicles at the pseudopodial tips
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol3
    cytoskeleton2
    endosome2
    mitochondrion1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0016020membrane ----
    GO:0016023cytoplasmic membrane-bounded vesicle IEA--

    Find genes that share ontologies with RAB25           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RAB25 About    
    See pathways by source

    SuperPathContained pathways About
    1Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions0.36
    2Cytoskeletal Signaling
    Cytoskeletal Signaling


    Find genes that share SuperPaths with RAB25           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for RAB25
        Epithelial Tight Junctions

    1 Cell Signaling Technology (CST) Pathway for RAB25
        Cytoskeletal Signaling



        Pathway & Disease-focused RT2 Profiler PCR Arrays including RAB25: 
              Necrosis in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Cell Death PathwayFinder in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RAB25

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RAB25 (P577353 ENSP000003543764) via UniProtKB, MINT, STRING, and/or I2D (see all 55)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACVR1Q047713, ENSP000002636404I2D: score=3 STRING: ENSP00000263640
    PKIGQ9Y2B93, ENSP000003380674I2D: score=2 STRING: ENSP00000338067
    RAB11FIP3O751543, ENSP000002623054I2D: score=2 STRING: ENSP00000262305
    RAB11FIP5Q9BXF63, ENSP000002580984I2D: score=2 STRING: ENSP00000258098
    D2HGDHQ8N4653, ENSP000003153514I2D: score=1 STRING: ENSP00000315351
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process ----
    GO:0006886intracellular protein transport ----
    GO:0006913nucleocytoplasmic transport ----
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction IEA--

    Find genes that share ontologies with RAB25           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RAB25

    1 Novoseek inferred chemical compound relationship for RAB25 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 38.1 2 8360141 (2)



    Find genes that share compounds with RAB25           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RAB25 gene: 
    NM_020387.2  

    Unigene Cluster for RAB25:

    RAB25, member RAS oncogene family
    Hs.632469  [show with all ESTs]
    Unigene Representative Sequence: BE612887
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361084(uc001fnc.3) ENST00000463614 ENST00000487325 ENST00000473336
    ENST00000497968
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat RAB25
      QuantiFast Probe-based Assays in human, mouse, rat RAB25

    Additional mRNA sequence: 

    AF083124.1 AF274025.1 BC004416.1 BC009831.2 BC033322.1 

    10 DOTS entries:

    DT.317133  DT.86842442  DT.100792538  DT.97846953  DT.121330569  DT.92437040  DT.100792540  DT.97846954 
    DT.100792542  DT.121330629 

    Selected AceView cDNA sequences (see all 198):

    BG682384 AA403293 BM833326 BM842447 BM987996 CA440159 BQ933120 BM824143 
    BU789098 BE272246 BM984733 BF000439 BF437335 BM831275 BM811535 BM763767 
    AA858248 BE742686 AI246699 BG292330 BM762058 AA337947 CR599507 BG680066 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RAB25 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b
    SP1:                          -     -                 -               
    SP2:              -     -     -     -                 -               
    SP3:                                                  -               
    SP4:              -     -     -     -                                 
    SP5:                    -     -     -                                 


    ECgene alternative splicing isoforms for RAB25

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RAB25 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCTATCACA
    RAB25 Expression
    About this image


    RAB25 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     NULL (Uncategorized)
             Vascular endothelial growth factor-induced cells
     
     Inner Cell Mass (Early Embryonic Tissues)
             C2a
     
     Kidney (Urinary System)
             Ureteric Bud
     
     Thyroid (Endocrine System)
     
     Colon (Gastrointestinal Tract)
    RAB25 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RAB25 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632469

    UniProtKB/Swiss-Prot: RAB25_HUMAN, P57735
    Tissue specificity: Expressed in ovarian epithelium (NOE) and breast tissue. Expressed in ovarian cancer;
    expression is increased relative to NOE cells. Expression in ovarian cancer is stage dependent, with stage III
    and stage IV showing higher levels than early stage cancers. Expressed in breast cancer; expression is increased
    relative to normal breast tissue

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RAB25: 
              Necrosis in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Cell Death PathwayFinder in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat RAB25
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB25

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RAB25 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rab251 , 5 RAB25, member RAS oncogene family1, 5 90.61(n)1
    95.77(a)1
      3 (38.87 cM)5
    538681  NM_016899.41  NP_058595.21 
     885420295 
    chicken
    (Gallus gallus)
    Aves RAB251 RAB25, member RAS oncogene family 73.56(n)
    83.24(a)
      100858582  XM_003643795.2  XP_003643843.2 
    African clawed frog
    (Xenopus laevis)
    Amphibia 480535112   -- 75.13(n)    48053511 
    zebrafish
    (Danio rerio)
    Actinopterygii rab25a1 RAB25, member RAS oncogene family a 66.83(n)
    71.78(a)
      494098  NM_001008641.1  NP_001008641.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rab116
    Rab-protein 11
    58(a)
    1 → many
    3R(16937130-16941868)
    worm
    (Caenorhabditis elegans)
    Secernentea rab-11.16
    rab-11.26
    Protein RAB-11.1 (rab-11.1) mRNA, complete cds
    Protein RAB-11.2, isoform a (rab-11.2) mRNA, compl...
    59(a)
    56(a)
    many ↔ many
    many ↔ many
    I(108686-110077) WBGene00004274
    I(11633002-11638491) WBGene00004275
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YPT326
    YPT316
    Rab family GTPase, very similar to Ypt31p; involve...
    Rab family GTPase, very similar to Ypt32p; involve...
    49(a)
    49(a)
    many ↔ many
    many ↔ many
    VII(93792-94460) YGL210W
    V(214076-214747) YER031C


    ENSEMBL Gene Tree for RAB25 (if available)
    TreeFam Gene Tree for RAB25 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RAB25 gene
    RAB192  RAB39A2  RAB2A2  RAB432  RAB142  RAB4B2  RAB39B2  RAB11B2  
    RAB11A2  RAB422  RAB4A2  RAB302  RAB4B-EGLN22  RAB2B2  
    Selected SIMAP similar genes for RAB25 using alignment to 1 protein entry:     RAB25_HUMAN(see all similar genes):
    RAB11A    RAB11B    RAB8B    RAB3A    RAB17    RAB19
    RAB8A    RAB5B    RAB5C    RAB13    RAB43    RAB30
    RAB37    RAB41    RAB7A    RAB2A    DKFZp313C1541    DKFZp686J07132

    Find genes that share paralogs with RAB25           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RAB25 (see all 201)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs756590321,2
    F--156029009(+) ACAGCC/TTAGAA 1 -- us2k11Minor allele frequency- T:0.50NA 4
    rs1499952441,2
    --156029036(+) TCTTCC/TTCCAG 1 -- us2k10--------
    rs1868051711,2
    --156029065(+) AGACCA/CTCCCC 1 -- us2k10--------
    rs1452006181,2
    --156029144(+) AGTAAC/TCCAGA 1 -- us2k10--------
    rs1114525911,2
    F--156029509(+) ACCCCA/C/GCTACC 1 -- us2k11CSA 2
    rs1423988481,2
    --156029514(+) CCTACC/TAGCTC 1 -- us2k10--------
    rs1814659201,2
    --156029609(+) GCAATA/GGCACA 1 -- us2k10--------
    rs1854452921,2
    --156029824(+) GGGATG/TACAGG 1 -- us2k10--------
    rs1899540841,2
    C--156029840(+) GCCACC/TGCACC 1 -- us2k10--------
    rs1808599451,2
    --156029857(+) CTTTTC/TTTTTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RAB25 (156030951 - 156040295 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RAB25:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509513CNV Insertion20534489

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RAB25
    DNA2.0 Custom Variant and Variant Library Synthesis for RAB25

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612942    OMIM disorders: --


    Find genes that share disorders with RAB25           About GenesLikeMe

    Genetic Association Database (GAD): RAB25

    Export disorders for RAB25 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RAB25 gene, integrated from 10 sources (see all 45):
    (articles sorted by number of sources associating them with RAB25)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments. (PubMed id 17925226)1, 2, 9 Caswell P.T.... Norman J.C. (Dev. Cell 2007)
    2. Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. (PubMed id 21292315)1, 4  ....Wood N.W. (Lancet 2011)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers. (PubMed id 15502842)1, 2 Cheng K.W.... Mills G.B. (Nat. Med. 2004)
    5. Identification and characterization of a family of Rab11-interacting proteins. (PubMed id 11495908)1, 2 Hales C.M.... Goldenring J.R. (J. Biol. Chem. 2001)
    6. Evolution of the Rab family of small GTP-binding proteins. (PubMed id 11697911)1, 3 Pereira-Leal J.B. and Seabra M.C. (J. Mol. Biol. 2001)
    7. Identification of a small GTP-binding protein, Rab25, expressed in the gastrointestinal mucosa, kidney, and lung. (PubMed id 8360141)1, 9 Goldenring J.R....Modlin I.M. (J. Biol. Chem. 1993)
    8. Loss of Rab25 promotes the development of intestinal neoplasia in mice and is associated with human colorectal adenocarcinomas. (PubMed id 20197623)1, 9 Nam K.T....Goldenring J.R. (J. Clin. Invest. 2010)
    9. Tumor suppressor function of Rab25 in triple-negative breast cancer. (PubMed id 19795443)1, 9 Cheng J.M....Rao K.A. (Int. J. Cancer 2010)
    10. Increased immunoreactivity for Rab11, a small GTP-binding protein, in low-grade dysplastic Barrett's epithelia. (PubMed id 9389793)1, 9 Ray G.S....Goldenring J.R. ( a journal of technical methods and pathology 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57111 HGNC: 18238 AceView: RAB25 Ensembl:ENSG00000132698 euGenes: HUgn57111
    ECgene: RAB25 H-InvDB: RAB25

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RAB25 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAB25 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RAB25 gene:
    Search GeneIP for patents involving RAB25

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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