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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RAB24 Gene

protein-coding   GIFtS: 53
GCID: GC05M176728

RAB24, member RAS oncogene family

 Explore 3 diseases affiliated with
RAB24 via our new
 Human Malady Compendium 
Biological research products
for RAB24
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
RAB24, Member RAS Oncogene Family1 2
Ras-Related Protein Rab-242

External Ids:    HGNC: 97651   Entrez Gene: 539172   Ensembl: ENSG000001692287   OMIM: 6124155   UniProtKB: Q969Q53   

Export aliases for RAB24 gene to outside databases

Previous GC identifers: GC05M177101 GC05M177570 GC05M176663 GC05M176709 GC05M176660 GC05M171648


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RAB24:
RAB24 is a small GTPase of the Rab subfamily of Ras-related proteins that regulate intracellular protein trafficking
(Olkkonen et al., 1993 (PubMed 8126105)).(supplied by OMIM, Aug 2009)

UniProtKB/Swiss-Prot: RAB24_HUMAN, Q969Q5
Function: May be involved in autophagy-related processes (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_023133.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RAB24 gene promoter:
         AML1a   RelA   NF-kappaB   Gfi-1   HEN1   ARP-1   STAT3   IRF-7A   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RAB24 promoter sequence
   Search SABiosciences Chromatin IP Primers for RAB24

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB24


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.3   Ensembl cytogenetic band:  5q35.3   HGNC cytogenetic band: 5q35.3

RAB24 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAB24 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M176728:  view genomic region     (about GC identifiers)

Start:
176,728,199 bp from pter      End:
176,730,745 bp from pter
Size:
2,547 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RAB24_HUMAN, Q969Q5 (See protein sequence)
Recommended Name: Ras-related protein Rab-24  
Size: 203 amino acids; 23124 Da
Subunit: Unlike other Rab family members, does not interact with GDP dissociation inhibitors (GDIs), including ARHGDIA
and ARHGDIB. Interacts with ZFYVE20
Subcellular location: Cytoplasm, cytosol. Membrane; Lipid-anchor (By similarity). Note=Only about 20-25% is recovered
in the particulate fraction
Miscellaneous: The unusual Ser-67, instead of a conserved Gln in other family members, is the cause of low GTPase
activity. As a result, the predominant nucleotide associated with the protein is GTP (By similarity)
Secondary accessions: Q7Z4Z7

Explore the universe of human proteins at neXtProt for RAB24: NX_Q969Q5

Post-translational modifications:

  • Isoprenylation is inefficient compared to other Rab family members1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q969Q5

  • RAB24 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001026847.1  NP_570137.2  

    ENSEMBL proteins: 
     ENSP00000377235   ENSP00000304376   ENSP00000302085   ENSP00000421442  

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    ProSpec Recombinant Protein for RAB24
    Uscn Proteins for RAB24

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--
    GO:0005776autophagic vacuole IEA--
    GO:0005829cytosol IEA--
    GO:0016020membrane IEA--


    RAB24 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    RAB24 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR003579 Small_GTPase_Rab_type

    Graphical View of Domain Structure for InterPro Entry Q969Q5

    ProtoNet protein and cluster: Q969Q5

    1 Blocks protein family: IPB001806 Transforming protein P21 RAS signature

    UniProtKB/Swiss-Prot: RAB24_HUMAN, Q969Q5
    Similarity: Belongs to the small GTPase superfamily. Rab family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: RAB24_HUMAN, Q969Q5
    Function: May be involved in autophagy-related processes (By similarity)
    Induction: By extensive retinoic acid treatment, in Ntera-2 teratoma cell line induced to differentiate into
    post-mitotic neurons (NTN2) (at protein level)

    miRNA
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    hsa-miR-615-5p hsa-miR-185* hsa-miR-148b hsa-miR-3166 hsa-miR-128 hsa-miR-3681* hsa-miR-152 hsa-miR-661
    SwitchGear 3'UTR luciferase reporter plasmidRAB24 3' UTR sequence
    Inhib. RNA
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16034420
    GO:0005525GTP binding IEA--


    RAB24 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions0.36

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RAB24
        Epithelial Tight Junctions


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RAB24

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/181 Interacting proteins for RAB24 (Q969Q53 ENSP000003043764) via UniProtKB, MINT, STRING, and/or I2D (see all 181)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006914autophagy IEA--
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0015031protein transport IEA--


    RAB24 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RAB24
    Search CenterWatch for drugs/clinical trials and news about RAB24 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RAB24 gene (2 alternative transcripts): 
    NM_001031677.2  NM_130781.2  

    Unigene Cluster for RAB24:

    RAB24, member RAS oncogene family
    Hs.16258  [show with all ESTs]
    Unigene Representative Sequence: BF569067
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000478234(uc003mfv.3 uc003mfw.3) ENST00000393611 ENST00000495458
    ENST00000303251 ENST00000303270 ENST00000471466 ENST00000393610 ENST00000504395
    ENST00000512758

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    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate RAB24 (see all 11):
    hsa-miR-615-5p hsa-miR-185* hsa-miR-148b hsa-miR-3166 hsa-miR-128 hsa-miR-3681* hsa-miR-152 hsa-miR-661
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    Inhib. RNA
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    Additional cDNA sequence: 

    AF087904.1 AK308155.1 AL833898.1 BC010006.2 BC015534.1 BC021263.2 BT007268.1 

    22 DOTS entries:

    DT.100821934  DT.97855774  DT.120865378  DT.100821945  DT.95229548  DT.100821940  DT.97804529  DT.100821942 
    DT.65288081  DT.120865267  DT.120865308  DT.100821938  DT.100821944  DT.120865356  DT.100821946  DT.120865302 
    DT.120865358  DT.91756282  DT.95213853  DT.95229549  DT.111589  DT.120865263 

    24/709 AceView cDNA sequences (see all 709):

    AI160267 BI829480 BM475000 CB306163 CB145624 BM699876 BM793394 CB135992 
    BQ653169 BF917592 T29958 AA745918 BM550553 AI918892 BU156514 BM477341 
    BU163660 BM919891 CA454858 BX098335 BX422647 AW955253 CR598835 BI223118 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RAB24    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b
    SP1:                                            -               
    SP2:                    -                                       
    SP3:                                                            
    SP4:                                            -               
    SP5:                                                            


    ECgene alternative splicing isoforms for RAB24

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RAB24 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGGAGGGATA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See RAB24 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RAB24

    SOURCE GeneReport for Unigene cluster: Hs.16258
        SABiosciences Expression via Pathway-Focused PCR Array including RAB24: 
              Autophagy in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RAB24 gene from 6/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rab241 , 5 RAB24, member RAS oncogene family1, 5 89(n)1
    98.52(a)1
      13 (29.80 cM)5
    193361  NM_009000.31  NP_033026.11 
     553192235 
    chicken
    (Gallus gallus)
    Aves RAB241 RAB24, member RAS oncogene family 78.98(n)
    80.79(a)
      427627  XM_425199.3  XP_425199.3 
    lizard
    (Anolis carolinensis)
    Reptilia RAB246
    --
    85(a)
    1 ↔ 1
    2(145433196-145438477)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.99372 Xenopus laevis transcribed sequence with moderate similarity to protein refNP_570137.1 (H.sapiens) RAB24 gene product [Homo sapiens] less 78.44(n)    BJ617214.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rab241 RAB24, member RAS oncogene family 69.47(n)
    76.24(a)
      574423  NM_001029970.1  NP_001025141.1 
    honey bee
    (Apis mellifera)
    Insecta --
    --
    55(a)
    1 ↔ 1
    GroupUn.77(65828-66911)


    ENSEMBL Gene Tree for RAB24 (if available)
    TreeFam Gene Tree for RAB24 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RAB24 gene
    RAB5C2  RAB202  RAB312  ENSG000002672612  RAB5B2  RAB212  RAB5A2  RAB22A2  
    RAB172  
    18/58 SIMAP similar genes for RAB24 using alignment to 5 protein entries:     RAB24_HUMAN (see all proteins) (see all similar genes):
    rab1b    RAB5C    RAB21    RAB5B    RAB17    RAB6A
    RAB6A'    RAB4B    RAB6B    RAB14    RAB31    RAB35
    RAB38    RAB5A    RAB11A    RAB7A    RAB4A    RAB19

    RAB24 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/34 NCBI SNPs in RAB24 are shown (see all 34    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1889406941,2
    --176727790(+) TGATTC/TCTCAG 2 -- ds50010--------
    rs771547331,2
    C--176727962(+) GTAGTC/TACCTT 2 -- ds50010--------
    rs766731881,2
    F,--176728228(+) TATTTC/GGAAGC 2 -- ut311Minor allele frequency- G:0.06WA 118
    rs1401175651,2
    --176728292(+) ACAGCC/TCCAGT 2 -- ut310--------
    rs1392623961,2
    C,--176728319(+) TGGGG-/AAAAAA 2 -- ut310--------
    rs1503678971,2
    --176728328(+) AAGTCC/TTGTTT 2 -- ut310--------
    rs1156242041,2
    C,F,--176728332(+) CTTGTT/CTTCCA 2 -- ut311Minor allele frequency- C:0.02WA 118
    rs284191821,2
    C,F,--176728400(+) CCCAGA/GAAGAA 2 -- ut3112Minor allele frequency- G:0.25NA WA CSA EA 376
    rs1810893411,2
    --176728457(+) TGTGAG/TGCACA 2 -- ut310--------
    rs11282871,2
    C,F,H,--176728458(-) CTGTGA/CATCAC 2 -- ut31 ese325Minor allele frequency- C:0.27MN NS EA NA WA CSA 2534

    HapMap Linkage Disequilibrium report for RAB24 (176728199 - 176730745 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for RAB24
         1 CNV: 3589

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    RAB24 for disorders           About GeneDecksing

    OMIM gene information: 612415    OMIM disorders: --

    3 diseases for RAB24:    About MalaCards
    q fever    teratoma    neuronitis

    1 disease from the University of Copenhagen DISEASES database for RAB24:
    Q fever
    Human Genome Epidemiology (HuGE) Navigator: RAB24 (1 document)

    Export disorders for RAB24 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RAB24 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with RAB24)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structural basis of family-wide Rab GTPase recognition by rabenosyn- 5. (PubMed id 16034420)1, 2 Eathiraj S.... Lambright D.G. (2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Rab24 is an atypical member of the Rab GTPase family. Deficient GTPase activity, GDP dissociation inhibitor interaction, and prenylation of Rab24 expressed in cultured cells. (PubMed id 10660536)1, 2 Erdman R.A....Maltese W.A. (2000)
    4. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    5. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    6. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    7. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    8. Network organization of the human autophagy system. (PubMed id 20562859)1 Behrends C....Harper J.W. (2010)
    9. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
    10. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 53917 HGNC: 9765 AceView: LMAN2andMXD3andRAB24 Ensembl:ENSG00000169228 euGenes: HUgn53917
    ECgene: RAB24 H-InvDB: RAB24

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RAB24 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAB24 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RAB24 gene:
    Search GeneIP for patents involving RAB24

    GeneCards and IP:
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