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Aliases for RAB24 Gene

Aliases for RAB24 Gene

  • RAB24, Member RAS Oncogene Family 2 3 5

External Ids for RAB24 Gene

Previous GeneCards Identifiers for RAB24 Gene

  • GC05M177101
  • GC05M177570
  • GC05M176663
  • GC05M176709
  • GC05M176660
  • GC05M176728
  • GC05M171648

Summaries for RAB24 Gene

Entrez Gene Summary for RAB24 Gene

  • RAB24 is a small GTPase of the Rab subfamily of Ras-related proteins that regulate intracellular protein trafficking (Olkkonen et al., 1993 [PubMed 8126105]).[supplied by OMIM, Aug 2009]

GeneCards Summary for RAB24 Gene

RAB24 (RAB24, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Immune System and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB5A.

UniProtKB/Swiss-Prot for RAB24 Gene

  • May be involved in autophagy-related processes.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB24 Gene

Genomics for RAB24 Gene

Regulatory Elements for RAB24 Gene

Enhancers for RAB24 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F177425 1.6 FANTOM5 ENCODE 9.1 -125.6 -125628 8.6 HDGF PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 GRK6 DOK3 FAF2 UIMC1 PFN3 DBN1 SLC34A1 ENSG00000248996 LOC202181 MXD3
GH05F177298 1.1 ENCODE 12.4 +0.6 574 10.3 HDGF PKNOX1 MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZNF143 FOS PRELID1 RGS14 MXD3 RAB24 TSPAN17 GC05P177297
GH05F177324 1.1 Ensembl ENCODE 11.5 -22.1 -22087 1.7 ELF3 MLX ARID4B DMAP1 RARA ZNF366 FOS CREM MIXL1 CEBPB LMAN2 RGS14 SLC34A1 RAB24 PRELID1 FGFR4 MXD3 GC05M177340
GH05F177231 1.1 Ensembl ENCODE 11.4 +70.9 70856 1.9 PKNOX1 ATF1 KLF17 SIN3A ZNF2 RAD21 ZNF48 ZNF335 ZNF366 ZNF143 RGS14 PRELID1 RAB24 MXD3 TSPAN17 RPL21P60 NSD1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RAB24 on UCSC Golden Path with GeneCards custom track

Promoters for RAB24 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for RAB24 Gene

177,301,190 bp from pter
177,303,744 bp from pter
2,555 bases
Minus strand

Genomic View for RAB24 Gene

Genes around RAB24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB24 Gene

Proteins for RAB24 Gene

  • Protein details for RAB24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras-related protein Rab-24
    Protein Accession:
    Secondary Accessions:
    • A0A024R7N9
    • Q7Z4Z7

    Protein attributes for RAB24 Gene

    203 amino acids
    Molecular mass:
    23124 Da
    Quaternary structure:
    • Unlike other Rab family members, does not interact with GDP dissociation inhibitors (GDIs), including ARHGDIA and ARHGDIB. Interacts with ZFYVE20.
    • The unusual Ser-67, instead of a conserved Gln in other family members, is the cause of low GTPase activity. As a result, the predominant nucleotide associated with the protein is GTP (By similarity).

neXtProt entry for RAB24 Gene

Post-translational modifications for RAB24 Gene

  • Isoprenylation is inefficient compared to other Rab family members.
  • Ubiquitination at Lys 104
  • Modification sites at PhosphoSitePlus

Other Protein References for RAB24 Gene

No data available for DME Specific Peptides for RAB24 Gene

Domains & Families for RAB24 Gene

Gene Families for RAB24 Gene

Protein Domains for RAB24 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Rab family.
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB24: view

Function for RAB24 Gene

Molecular function for RAB24 Gene

UniProtKB/Swiss-Prot Function:
May be involved in autophagy-related processes.
UniProtKB/Swiss-Prot Induction:
By extensive retinoic acid treatment, in Ntera-2 teratoma cell line induced to differentiate into post-mitotic neurons (NTN2) (at protein level).

Gene Ontology (GO) - Molecular Function for RAB24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16034420
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RAB24: view
genes like me logo Genes that share phenotypes with RAB24: view

Animal Models for RAB24 Gene

MGI Knock Outs for RAB24:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for RAB24 Gene

Localization for RAB24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB24 Gene

Cytoplasm, cytosol. Membrane; Lipid-anchor. Note=Only about 20-25% is recovered in the particulate fraction. {ECO:0000269 PubMed:10660536}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB24 gene
Compartment Confidence
plasma membrane 5
cytosol 5
mitochondrion 2
extracellular 1
nucleus 1
lysosome 1
endosome 1

Gene Ontology (GO) - Cellular Components for RAB24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005776 autophagosome IBA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with RAB24: view

Pathways & Interactions for RAB24 Gene

genes like me logo Genes that share pathways with RAB24: view

Pathways by source for RAB24 Gene

Gene Ontology (GO) - Biological Process for RAB24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006914 autophagy IEA --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with RAB24: view

No data available for SIGNOR curated interactions for RAB24 Gene

Transcripts for RAB24 Gene

Unigene Clusters for RAB24 Gene

RAB24, member RAS oncogene family:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB24 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b
SP1: -
SP2: -
SP4: -

Relevant External Links for RAB24 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RAB24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RAB24 Gene

mRNA differential expression in normal tissues according to GTEx for RAB24 Gene

This gene is overexpressed in Whole Blood (x8.2).

Protein differential expression in normal tissues from HIPED for RAB24 Gene

This gene is overexpressed in Brain (9.8), Peripheral blood mononuclear cells (9.1), and Bone (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RAB24 Gene

Protein tissue co-expression partners for RAB24 Gene

NURSA nuclear receptor signaling pathways regulating expression of RAB24 Gene:


SOURCE GeneReport for Unigene cluster for RAB24 Gene:

genes like me logo Genes that share expression patterns with RAB24: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for RAB24 Gene

Orthologs for RAB24 Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB24 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RAB24 34 35
  • 99.84 (n)
(Bos Taurus)
Mammalia RAB24 35
  • 98 (a)
(Monodelphis domestica)
Mammalia RAB24 35
  • 97 (a)
(Canis familiaris)
Mammalia RAB24 34 35
  • 93.92 (n)
(Mus musculus)
Mammalia Rab24 34 16 35
  • 89 (n)
(Gallus gallus)
Aves RAB24 34 35
  • 79.8 (n)
(Anolis carolinensis)
Reptilia RAB24 35
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rab24 34
  • 72.25 (n)
Str.14066 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.9937 34
(Danio rerio)
Actinopterygii rab24 34 35
  • 69.47 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11639 34
fruit fly
(Drosophila melanogaster)
Insecta chrw 35
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 31 (a)
Species where no ortholog for RAB24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAB24 Gene

Gene Tree for RAB24 (if available)
Gene Tree for RAB24 (if available)

Paralogs for RAB24 Gene

Variants for RAB24 Gene

Sequence variations from dbSNP and Humsavar for RAB24 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1128287 -- 177,301,457(-) CTGTG(A/C)ATCAC nc-transcript-variant, utr-variant-3-prime
rs114657100 -- 177,303,779(+) ACTGT(A/G)TGGCT upstream-variant-2KB, utr-variant-5-prime
rs114938354 -- 177,305,484(+) TTACA(C/G)GCGTG intron-variant, downstream-variant-500B, upstream-variant-2KB
rs11545840 -- 177,304,748(+) CCTGC(C/T)AATGT upstream-variant-2KB, reference, synonymous-codon
rs115624204 -- 177,301,331(+) CTTGT(C/T)TTCCA nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RAB24 Gene

Variant ID Type Subtype PubMed ID
nsv600364 CNV loss 21841781
nsv428132 CNV gain 18775914
esv2759396 CNV gain 17122850

Variation tolerance for RAB24 Gene

Residual Variation Intolerance Score: 25.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.12; 2.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAB24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB24 Gene

Disorders for RAB24 Gene

Relevant External Links for RAB24

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RAB24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB24 Gene

Publications for RAB24 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  2. Structural basis of family-wide Rab GTPase recognition by rabenosyn- 5. (PMID: 16034420) Eathiraj S. … Lambright D.G. (Nature 2005) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Rab24 is an atypical member of the Rab GTPase family. Deficient GTPase activity, GDP dissociation inhibitor interaction, and prenylation of Rab24 expressed in cultured cells. (PMID: 10660536) Erdman R.A. … Maltese W.A. (J. Biol. Chem. 2000) 3 4 64
  5. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd B.J. … Pagliarini D.J. (Mol. Cell 2016) 3 64

Products for RAB24 Gene

Sources for RAB24 Gene

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