RAB24 Gene
protein-coding GIFtS: 53
GCID: GC05M176728
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RAB24, member RAS oncogene family
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Aliases for RAB24 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| RAB24, Member RAS Oncogene Family1 2 | | Ras-Related Protein Rab-242 |
Export aliases for RAB24 gene to outside databasesPrevious GC identifers: GC05M177101 GC05M177570 GC05M176663 GC05M176709 GC05M176660 GC05M171648 |
Summaries for RAB24 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for RAB24: RAB24 is a small GTPase of the Rab subfamily of Ras-related proteins that regulate intracellular protein trafficking(Olkkonen et al., 1993 (PubMed 8126105)).(supplied by OMIM, Aug 2009) UniProtKB/Swiss-Prot: RAB24_HUMAN, Q969Q5Function: May be involved in autophagy-related processes (By similarity)
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Genomic Views for RAB24 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_023133.13
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the RAB24 gene promoter: AML1a RelA NF-kappaB Gfi-1 HEN1 ARP-1 STAT3 IRF-7A NF-kappaB1 Other transcription factors
Search SABiosciences Chromatin IP Primers for RAB24
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB24 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q35.3 Ensembl cytogenetic band: 5q35.3 HGNC cytogenetic band: 5q35.3RAB24 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M176728: view genomic region
(about GC identifiers)
Start:
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176,728,199 bp from pter |
End:
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176,730,745 bp from pter |
Size:
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2,547 bases |
Orientation:
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minus strand |
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Proteins for RAB24 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: RAB24_HUMAN, Q969Q5 (See
protein sequence)Recommended Name: Ras-related protein Rab-24 Size: 203 amino acids; 23124 Da
Subunit: Unlike other Rab family members, does not interact with GDP dissociation inhibitors (GDIs), including ARHGDIAand ARHGDIB. Interacts with ZFYVE20
Subcellular location: Cytoplasm, cytosol. Membrane; Lipid-anchor (By similarity). Note=Only about 20-25% is recoveredin the particulate fraction
Miscellaneous: The unusual Ser-67, instead of a conserved Gln in other family members, is the cause of low GTPaseactivity. As a result, the predominant nucleotide associated with the protein is GTP (By similarity)
Secondary accessions: Q7Z4Z7Explore the universe of human proteins at neXtProt for RAB24: NX_Q969Q5
Post-translational modifications:
Isoprenylation is inefficient compared to other Rab family members1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q969Q5 RAB24 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001026847.1 NP_570137.2 ENSEMBL proteins: ENSP00000377235 ENSP00000304376 ENSP00000302085 ENSP00000421442 Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
RAB24 for ontologies About GeneDecksing
RAB24 Antibody Products: Assay Products for RAB24: |
Protein
Domains / Families for RAB24 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RAB24 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q969Q5ProtoNet protein and cluster: Q969Q5 1 Blocks protein family: IPB001806 Transforming protein P21 RAS signature
UniProtKB/Swiss-Prot: RAB24_HUMAN, Q969Q5Similarity: Belongs to the small GTPase superfamily. Rab family |
Function for RAB24 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: RAB24_HUMAN, Q969Q5Function: May be involved in autophagy-related processes (By similarity)Induction: By extensive retinoic acid treatment, in Ntera-2 teratoma cell line induced to differentiate intopost-mitotic neurons (NTN2) (at protein level)
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAB24 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAB24 (see all 5) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): RAB24 (NM_130781) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RAB24 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB24  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB24 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
RAB24 for ontologies About GeneDecksing
|
Pathways & Interactions for RAB24 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Sertoli-Sertoli Cell Junction Dynamics | |
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RAB24
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RAB24
STRING Interaction
Network Preview (showing 5 interactants - click image to see 11)
 5/181 Interacting proteins for RAB24 (Q969Q53 ENSP000003043764) via UniProtKB, MINT, STRING, and/or I2D (see all 181)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006914 | autophagy |
IEA | -- | | GO:0007264 | small GTPase mediated signal transduction |
IEA | -- | | GO:0015031 | protein transport |
IEA | -- |
RAB24 for ontologies About GeneDecksing
|
Drugs & Compounds for RAB24 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for RAB24 Search CenterWatch for drugs/clinical trials and news about RAB24 
|
Transcripts for RAB24 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for RAB24 gene (2 alternative transcripts): NM_001031677.2 NM_130781.2 Unigene Cluster for RAB24: RAB24, member RAS oncogene family Hs.16258 [show with all ESTs]Unigene Representative Sequence: BF5690679 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000478234(uc003mfv.3 uc003mfw.3) ENST00000393611 ENST00000495458 ENST00000303251 ENST00000303270 ENST00000471466 ENST00000393610 ENST00000504395 ENST00000512758
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAB24 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAB24 (see all 5) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): RAB24 (NM_130781) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RAB24 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB24  |
Additional cDNA sequence: AF087904.1 AK308155.1 AL833898.1 BC010006.2 BC015534.1 BC021263.2 BT007268.1 22 DOTS entries: DT.100821934 DT.97855774 DT.120865378 DT.100821945 DT.95229548 DT.100821940 DT.97804529 DT.100821942 DT.65288081 DT.120865267 DT.120865308 DT.100821938 DT.100821944 DT.120865356 DT.100821946 DT.120865302 DT.120865358 DT.91756282 DT.95213853 DT.95229549 DT.111589 DT.120865263 24/709 AceView cDNA sequences (see all 709): AI160267 BI829480 BM475000 CB306163 CB145624 BM699876 BM793394 CB135992 BQ653169 BF917592 T29958 AA745918 BM550553 AI918892 BU156514 BM477341 BU163660 BM919891 CA454858 BX098335 BX422647 AW955253 CR598835 BI223118 GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for RAB24 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |
| SP2: | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for RAB24
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Expression for RAB24 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RAB24 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: AGGAGGGATA
About this image See RAB24 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for RAB24
SOURCE GeneReport for Unigene cluster: Hs.16258 SABiosciences Expression via Pathway-Focused PCR Array including RAB24:
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAB24 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RAB24 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAB24 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAB24 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB24 |
Orthologs for RAB24 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RAB24 gene from 6/16 species (see all 16) About this table
ENSEMBL Gene Tree for RAB24 (if available) TreeFam Gene Tree for RAB24 (if available)  |
Paralogs for RAB24 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for RAB24 gene
- RAB5C2 RAB202 RAB312 ENSG000002672612 RAB5B2 RAB212 RAB5A2 RAB22A2
- RAB172
18/58 SIMAP similar genes for RAB24 using alignment to 5 protein entries: RAB24_HUMAN (see all proteins)
(see all similar genes):rab1b RAB5C RAB21 RAB5B RAB17 RAB6A RAB6A' RAB4B RAB6B RAB14 RAB31 RAB35 RAB38 RAB5A RAB11A RAB7A RAB4A RAB19
RAB24 for paralogs About GeneDecksing
|
Genomic Variants for RAB24 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 5 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
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HapMap Linkage Disequilibrium report for RAB24 (176728199 - 176730745 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for RAB24 1 CNV: 3589  | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases for RAB24 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RAB24 for disorders About GeneDecksing
OMIM gene information: 612415
OMIM disorders: --
3 diseases for RAB24: About MalaCardsq fever teratoma neuronitis 1 disease from the University of Copenhagen DISEASES database for RAB24:Q fever Human Genome Epidemiology (HuGE) Navigator: RAB24 (1 document) Export disorders for RAB24 gene to outside databases
|
Publications for RAB24 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RAB24 gene, integrated from 9 sources (see all 16): (articles sorted by number of sources associating them with RAB24) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Structural basis of family-wide Rab GTPase recognition by rabenosyn- 5. (PubMed id 16034420)1, 2 Eathiraj S.... Lambright D.G. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Rab24 is an atypical member of the Rab GTPase family. Deficient GTPase activity, GDP dissociation inhibitor interaction, and prenylation of Rab24 expressed in cultured cells. (PubMed id 10660536)1, 2 Erdman R.A....Maltese W.A. (2000)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Network organization of the human autophagy system. (PubMed id 20562859)1 Behrends C....Harper J.W. (2010)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
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External Searches for RAB24 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing RAB24 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RAB24 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RAB24 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
|
About This Section
| Patent Information for RAB24 gene: Search GeneIP for patents involving RAB24
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for RAB24 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
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 | |
 | |
 |
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variant library, vector shuttling | | OriGene Custom Antibody Services for RAB24 | | OriGene Custom Protein Services for RAB24 | | OriGene Custom Immunoassay Development | | |
| |  |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RAB24 | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAB24 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB24 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAB24 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAB24 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAB24 |
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 |  |  |  | |
| | | Search Tocris compounds for RAB24 |
| |  |  |  |  | | | | | Recombinant Protein for RAB24 |
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 | | RAB24 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB24 |
|  |  |  | | | ThermoFisher Antibodies for RAB24 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB24 |
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