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Aliases for RAB24 Gene

Aliases for RAB24 Gene

  • RAB24, Member RAS Oncogene Family 2 3

External Ids for RAB24 Gene

Previous GeneCards Identifiers for RAB24 Gene

  • GC05M177101
  • GC05M177570
  • GC05M176663
  • GC05M176709
  • GC05M176660
  • GC05M176728
  • GC05M171648

Summaries for RAB24 Gene

Entrez Gene Summary for RAB24 Gene

  • RAB24 is a small GTPase of the Rab subfamily of Ras-related proteins that regulate intracellular protein trafficking (Olkkonen et al., 1993 [PubMed 8126105]).[supplied by OMIM, Aug 2009]

GeneCards Summary for RAB24 Gene

RAB24 (RAB24, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include GTP binding. An important paralog of this gene is RAB5C.

UniProtKB/Swiss-Prot for RAB24 Gene

  • May be involved in autophagy-related processes.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB24 Gene

Genomics for RAB24 Gene

Regulatory Elements for RAB24 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RAB24 Gene

177,301,190 bp from pter
177,303,744 bp from pter
2,555 bases
Minus strand

Genomic View for RAB24 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAB24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB24 Gene

Proteins for RAB24 Gene

  • Protein details for RAB24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras-related protein Rab-24
    Protein Accession:
    Secondary Accessions:
    • Q7Z4Z7

    Protein attributes for RAB24 Gene

    203 amino acids
    Molecular mass:
    23124 Da
    Quaternary structure:
    • Unlike other Rab family members, does not interact with GDP dissociation inhibitors (GDIs), including ARHGDIA and ARHGDIB. Interacts with ZFYVE20.
    • The unusual Ser-67, instead of a conserved Gln in other family members, is the cause of low GTPase activity. As a result, the predominant nucleotide associated with the protein is GTP (By similarity).

neXtProt entry for RAB24 Gene

Proteomics data for RAB24 Gene at MOPED

Post-translational modifications for RAB24 Gene

  • Isoprenylation is inefficient compared to other Rab family members
  • Ubiquitination at Lys104
  • Modification sites at PhosphoSitePlus

Other Protein References for RAB24 Gene

Antibody Products

No data available for DME Specific Peptides for RAB24 Gene

Domains for RAB24 Gene

Gene Families for RAB24 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Rab family.
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB24: view

Function for RAB24 Gene

Molecular function for RAB24 Gene

UniProtKB/Swiss-Prot Function:
May be involved in autophagy-related processes.
UniProtKB/Swiss-Prot Induction:
By extensive retinoic acid treatment, in Ntera-2 teratoma cell line induced to differentiate into post-mitotic neurons (NTN2) (at protein level).

Gene Ontology (GO) - Molecular Function for RAB24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IBA --
GO:0005515 protein binding IPI 16034420
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RAB24: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RAB24 Gene

Localization for RAB24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB24 Gene

Cytoplasm, cytosol. Membrane; Lipid-anchor. Note=Only about 20-25% is recovered in the particulate fraction.

Subcellular locations from

Jensen Localization Image for RAB24 Gene COMPARTMENTS Subcellular localization image for RAB24 gene
Compartment Confidence
cytosol 5
mitochondrion 2
vacuole 2
endosome 1
extracellular 1
golgi apparatus 1
lysosome 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RAB24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005739 mitochondrion IEA --
GO:0005768 endosome IBA --
GO:0005776 autophagic vacuole IBA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with RAB24: view

Pathways for RAB24 Gene

genes like me logo Genes that share pathways with RAB24: view

Pathways by source for RAB24 Gene

1 Qiagen pathway for RAB24 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for RAB24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport IBA --
GO:0006913 nucleocytoplasmic transport --
GO:0006914 autophagy IEA --
GO:0007165 signal transduction --
genes like me logo Genes that share ontologies with RAB24: view

Transcripts for RAB24 Gene

Unigene Clusters for RAB24 Gene

RAB24, member RAS oncogene family:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAB24 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b
SP1: -
SP2: -
SP4: -

Relevant External Links for RAB24 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RAB24 Gene

mRNA expression in normal human tissues for RAB24 Gene

mRNA differential expression in normal tissues according to GTEx for RAB24 Gene

This gene is overexpressed in Whole Blood (8.2).

Protein differential expression in normal tissues for RAB24 Gene

This gene is overexpressed in Brain (9.8), Peripheral blood mononuclear cells (9.1), and Bone (6.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB24 Gene

SOURCE GeneReport for Unigene cluster for RAB24 Gene Hs.16258

genes like me logo Genes that share expressions with RAB24: view

Expression partners for RAB24 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for RAB24 Gene

Orthologs for RAB24 Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB24 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia RAB24 35
  • 93.92 (n)
  • 99.01 (a)
RAB24 36
  • 99 (a)
(Mus musculus)
Mammalia Rab24 35
  • 89 (n)
  • 98.52 (a)
Rab24 16
Rab24 36
  • 99 (a)
(Pan troglodytes)
Mammalia RAB24 35
  • 99.84 (n)
  • 100 (a)
RAB24 36
  • 100 (a)
(Bos Taurus)
Mammalia RAB24 36
  • 98 (a)
(Monodelphis domestica)
Mammalia RAB24 36
  • 97 (a)
(Gallus gallus)
Aves RAB24 35
  • 79.8 (n)
  • 82.27 (a)
RAB24 36
  • 81 (a)
(Anolis carolinensis)
Reptilia RAB24 36
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rab24 35
  • 72.25 (n)
  • 79.8 (a)
Str.14066 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.9937 35
(Danio rerio)
Actinopterygii rab24 35
  • 69.47 (n)
  • 76.24 (a)
rab24 36
  • 76 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11639 35
fruit fly
(Drosophila melanogaster)
Insecta chrw 36
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
Species with no ortholog for RAB24:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAB24 Gene

Gene Tree for RAB24 (if available)
Gene Tree for RAB24 (if available)

Paralogs for RAB24 Gene

genes like me logo Genes that share paralogs with RAB24: view

Variants for RAB24 Gene

Sequence variations from dbSNP and Humsavar for RAB24 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs1128287 -- 177,301,457(-) CTGTG(A/C)ATCAC utr-variant-3-prime, nc-transcript-variant
rs28419182 -- 177,301,399(+) CCCAG(A/G)AAGAA utr-variant-3-prime, nc-transcript-variant
rs76673188 -- 177,301,227(+) TATTT(C/G)GAAGC utr-variant-3-prime, nc-transcript-variant
rs77154733 -- 177,300,961(+) GTAGT(C/T)ACCTT downstream-variant-500B
rs115624204 -- 177,301,331(+) CTTGT(C/T)TTCCA utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB24 Gene

Variant ID Type Subtype PubMed ID
dgv1878e1 CNV Complex 17122850
nsv428132 CNV Gain 18775914
dgv6379n71 CNV Loss 21882294
nsv883159 CNV Loss 21882294

Relevant External Links for RAB24 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB24 Gene

Disorders for RAB24 Gene

(1) University of Copenhagen DISEASES for RAB24 Gene

Relevant External Links for RAB24

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with RAB24: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for RAB24 Gene

Publications for RAB24 Gene

  1. Rab24 is an atypical member of the Rab GTPase family. Deficient GTPase activity, GDP dissociation inhibitor interaction, and prenylation of Rab24 expressed in cultured cells. (PMID: 10660536) Erdman R.A. … Maltese W.A. (J. Biol. Chem. 2000) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Structural basis of family-wide Rab GTPase recognition by rabenosyn- 5. (PMID: 16034420) Eathiraj S. … Lambright D.G. (Nature 2005) 3 4
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for RAB24 Gene

Sources for RAB24 Gene

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