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RAB24 Gene

protein-coding   GIFtS: 51

GC05M176660
RAB24, member RAS oncogene family
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for RAB24

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Descriptions
RAB24 gene product 2
RAB24, member RAS oncogene family 2
External Ids
HGNC: 97651
Entrez Gene: 539172
UniProtKB: Q969Q53
Ensembl: ENSG000001692287
Search outside databases for aliases for RAB24 gene

Previous GC identifers: GC05M177101 GC05M177570 GC05M176663 GC05M176709

Summaries
for RAB24

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for RAB24:
RAB24 is a small GTPase of the Rab subfamily of Ras-related proteins that regulate intracellular
protein trafficking.[supplied by OMIM]

UniProtKB/Swiss-Prot: RAB24_HUMAN, Q969Q5
Function: May be involved in autophagy-related processes (By similarity)

Genomic Location
for RAB24

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the RAB24 gene  

Entrez Gene cytogenetic band: 5q35.3   Ensembl cytogenetic band:  5q35.3   HGNC cytogenetic band: 5q35.3

RAB24 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M176660:     (about GC identifiers)

Start:
 176,660,805 bp from pter
End:
 176,663,350 bp from pter
Size:
 2,546 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000005.8  NT_023133.12  

Proteins
for RAB24

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: RAB24_HUMAN, Q969Q5 (See protein sequence)
Recommended Name: Ras-related protein Rab-24  
Size: 203 amino acids; 23124 Da
Subunit: Unlike other Rab family members, does not interact with GDP dissociation inhibitors
(GDIs), including ARHGDIA and ARHGDIB
Subcellular location: Cytoplasm, cytosol. Membrane; Lipid-anchor (By similarity). Note=Only about
20-25% is recovered in the particulate fraction
Miscellaneous: The unusual Ser-67, instead of a conserved Gln in other family members, is the cause
of low GTPase activity. As a result, the predominant nucleotide associated with the protein is GTP
(By similarity)
Secondary accessions: Q7Z4Z7

Post-translational modifications:

  • Isoprenylation is inefficient compared to other Rab family members1
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (2 alternative transcripts): 
    NP_001026847.1  NP_570137.2  


    ENSEMBL proteins: 
    ENSP00000377234 ENSP00000302085 ENSP00000304376 ENSP00000377235 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (Rab24)
    Human Recombinant Proteins from Abnova (RAB24)
                   OriGene Purified Recombinant Human Proteins (see all 2): RAB24  

    5 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005770 late endosome IEA--
    GO:0005783 endoplasmic reticulum IEA--
    GO:0005793 ER-Golgi intermediate compartment IEA--
    GO:0005794 Golgi apparatus IEA--
    GO:0016020 membrane IEA--
    About this table

    Antibodies for RAB24: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (Rab24), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (RAB24)
    Search Novus for antibodies for RAB24

    Assays for RAB24: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for RAB24

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro domains/families:
     IPR001806 Ras_GTPase
     IPR005225 Small_GTP_bd
     IPR003579 GTPase_Rab
     IPR013753 Ras


       GeneDecks  RAB24 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q969Q5

    ProtoNet protein and cluster: Q969Q5

    1 Blocks protein family: IPB001806 Transforming protein P21 RAS signature

    UniProtKB/Swiss-Prot: RAB24_HUMAN, Q969Q5
    Similarity: Belongs to the small GTPase superfamily. Rab family

    Gene Function
    for RAB24

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (RAB24)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001031677

                  Applied Biosystems Silencer® siRNAs for RAB24

                  Sigma-Aldrich siRNA for RAB24  
                         Sigma-Aldrich shRNA for RAB24  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for RAB24
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001031677
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001031677
                                     untagged cDNA clones in CMV expression vector (see all 5): BC010006 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_130781

    UniProtKB/Swiss-Prot: RAB24_HUMAN, Q969Q5
    Function: May be involved in autophagy-related processes (By similarity)
    Induction: By extensive retinoic acid treatment, in Ntera-2 teratoma cell line induced to
    differentiate into post-mitotic neurons (NTN2) (at protein level)

    2 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0005525 GTP binding IEA--
    About this table

    Pathways & Interactions
    for RAB24

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


      --

    3 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006914 autophagy IEA--
    GO:0007264 small GTPase mediated signal transduction IEA--
    GO:0015031 protein transport IEA--
    About this table

    Drugs & Compounds
    for RAB24

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Enzo Life Sciences drugs & compounds for RAB24
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for RAB24

    Transcripts
    for RAB24

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (RAB24)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001031677

                  Sigma-Aldrich siRNA for RAB24  
                         Sigma-Aldrich shRNA for RAB24  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001031677  NM_130781  

    REFSEQ mRNAs for RAB24 gene (2 alternative transcripts): 

    NM_001031677.2   NM_130781.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001031677  NM_130781  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001031677
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001031677
                                     untagged cDNA clones in CMV expression vector (see all 5): BC010006 

    Additional cDNA sequence: 

    AF087904.1 AK308155.1 AL833898.1 BC010006.2 BC015534.1 BC021263.2 BT007268.1 CR592574.1 
    CR595135.1 CR597078.1 CR598394.1 CR598835.1 CR602575.1 CR608115.1 CR613352.1 CR615395.1 
    CR620905.1 

    20 DOTS entries:

    DT.100821934  DT.97855774  DT.120865378  DT.97804529  DT.95229548  DT.100821945  DT.100821940  DT.100821942 
    DT.65288081  DT.120865267  DT.100821938  DT.120865308  DT.100821944  DT.120865356  DT.100821946  DT.120865302 
    DT.120865358  DT.91756282  DT.95213853  DT.95229549 

    24/709 AceView cDNA sequences (see all 709 ):

    CR593369 AW955253 CB216564 CR598835 CA487927 CR600342 BM666803 BF528039 
    BM550553 BE855421 BF448083 AL043471 AA938126 CR608422 NM_006816 BQ448329 
    AI923956 BX422647 BI826628 AA745918 AA160502 U10362 CR608115 BU620484 

    highest scoring ESTs for RAB24:

    AA214069 AI984189 AL570998 BE772904 BF568346 BM820880 BM849030 BM911879 BM926160 BU069543 

    Unigene Cluster for RAB24:

    RAB24, member RAS oncogene family
    Hs.16258  [show with all ESTs]
    Unigene Representative Sequence: CR595135


    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RAB24

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b
    SP1:                                            -               
    SP2:                    -                                       
    SP3:                                                            
    SP4:                                            -               
    SP5:                                                            

    About this scheme

    ECgene alternative splicing isoforms for RAB24

    4 Ensembl transcripts including schematic representations:
    ENST00000393610  ENST00000303270  ENST00000303251  ENST00000393611  

    Expression
    for RAB24

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    RAB24 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for RAB24

    1 / 2 / 3

    6 probe-sets matching RAB24 gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    		65454_at2, 3 U95-C 1 1.00 1.00 0.98 1.12 AI567436 0.80 0.83 0.82 1
    43451_at2, 3 U95-B 1 1.00 1.00 0.84 0.77 AI984189 0.60 1.00 0.82 1

    		60889_f_at2, 3 U95-C 1 1.00 1.00 0.95 1.11 AI376436 0.40 1.00 0.76 1

    		225251_at2, 3 U133-B 1 1.00 1.00 -- -- AK021761 0.60 0.78 0.69 1

    		225251_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		1555311_at2 U133Plus2 1 0.55 1.00 -- -- -- -- -- -- --
    GeneDecks  RAB24 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: AGGAGGGATA

    SOURCE GeneReport for Unigene cluster: Hs.16258

    Orthologs
    for RAB24

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for RAB24 gene from 5/8 species (see all 8 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 RAB241   -- RAB24, member RAS oncogene family 93.92(n)
    99.01(a)    		 479277  XM_536420.2  XP_536420.1 
    chimpanzee
    (Pan troglodytes)    		 RAB241   -- RAB24, member RAS oncogene family 99.84(n)
    100(a)    		 471755  XM_001139937.1  XP_001139937.1 
    mouse
    (Mus musculus)    		 Rab241, 5 13 (36.00 cM)5
    		 RAB24, member RAS oncogene family1, 5 89(n)1
    98.52(a)1    		 193361  NM_009000.21  NP_033026.11 
     AB2326195  AI4274455  (see all 19)
    chicken
    (Gallus gallus)    		 RAB241   -- RAB24, member RAS oncogene family 78.86(n)
    83.54(a)    		 427627  XM_425199.2  XP_425199.2 
    zebrafish
    (Danio rerio)    		 rab241   -- RAB24, member RAS oncogene family 69.47(n)
    76.24(a)    		 574423  NM_001029970.1  NP_001025141.1 
    About this table        Species with no ortholog for RAB24

    ENSEMBL Gene Tree for RAB24

    Paralogs
    for RAB24

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for RAB24 gene
    RAB312  RAB22A2  

    SNPs/Variants
    for RAB24

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    3 NCBI SNPs in RAB24 are shown
    (Click for Applied Biosystems TaqMan ® Genotyping Assay) (only AB snps)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 5 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs11282871,2
    		C,F176661064(-) CTGTGA/CATCAC 2 -- ut31 ese31Minor allele frequency- C:0.41MN 184
    rs284191821,2
    		--176661006(+) CCCAGA/GAAGAA 2 -- ut310--------
    rs287100141,2
    		--176661423(+) TCAAAA/GAGAGA 2 -- int1 trp30--------
    About this table
    The following additional 32 SNP(s) have been found in Applied Biosystems data source:
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)


     rs6886255 rs11740250 rs11949765 rs6872201 rs11952926 rs28580074 rs13190036
     rs35691394 rs4246814 rs61730553 rs11956153 rs28362590 rs6877852 rs4568379
     rs10051822 rs12659551 rs7732626 rs11953930 rs4076327 rs4073746 rs6879874
     rs28684504 rs34165241 rs11953271 rs28362591 rs4073745 rs11949767 rs4976682
     rs3088050 rs28362589 rs35848863 rs28670911

    HapMap Linkage Disequilibrium images for RAB24 (up to first 250kb)

    Disorders & Mutations
    for RAB24

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 612415

    Medical News
    for RAB24

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for RAB24

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		9 PubMed articles for RAB24 gene:

    Search for RAB24

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing RAB24

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 53917 HGNC: 9765 AceView: LMAN2andMXD3andRAB24 Ensembl:ENSG00000169228 euGenes: HUgn53917
    ECgene: RAB24 H-InvDB: RAB24

    Other Databases showing RAB24

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing RAB24

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for RAB24 Genetics and Cytogenetics in Oncology and Haematology

    Licensable Technologies
    for RAB24

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for RAB24

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for RAB24:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for RAB24-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for RAB24 Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for RAB24 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
     Antibodies   Primer Pairs  
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     Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
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     Recombinant & Natural Proteins  

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     Search for Chimera RNAi
     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
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     Recombinant Proteins
    (Rab24)
     Antibodies (Rab24)
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     Search Tocris compounds for RAB24




     Drugs for RAB24
     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Search Novus for antibodies for RAB24

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