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Aliases for RAB22A Gene

Aliases for RAB22A Gene

  • RAB22A, Member RAS Oncogene Family 2 3
  • Rab-22 3 4
  • Ras-Related Protein Rab-22A 3
  • GTP-Binding Protein RAB22A 3
  • RAB22 4

External Ids for RAB22A Gene

Previous GeneCards Identifiers for RAB22A Gene

  • GC20P056613
  • GC20P057523
  • GC20P057570
  • GC20P056318
  • GC20P056884
  • GC20P053667

Summaries for RAB22A Gene

Entrez Gene Summary for RAB22A Gene

  • The protein encoded by this gene is a member of the RAB family of small GTPases. The GTP-bound form of the encoded protein has been shown to interact with early-endosomal antigen 1, and may be involved in the trafficking of and interaction between endosomal compartments. [provided by RefSeq, Jul 2008]

GeneCards Summary for RAB22A Gene

RAB22A (RAB22A, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Endocytosis and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB5C.

UniProtKB/Swiss-Prot for RAB22A Gene

  • Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes. Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth. Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form.

Gene Wiki entry for RAB22A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB22A Gene

Genomics for RAB22A Gene

Regulatory Elements for RAB22A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RAB22A Gene

Start:
58,309,696 bp from pter
End:
58,367,507 bp from pter
Size:
57,812 bases
Orientation:
Plus strand

Genomic View for RAB22A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAB22A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB22A Gene

Proteins for RAB22A Gene

  • Protein details for RAB22A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UL26-RB22A_HUMAN
    Recommended name:
    Ras-related protein Rab-22A
    Protein Accession:
    Q9UL26
    Secondary Accessions:
    • B3KR86
    • E1P605
    • Q8TF12
    • Q9H4E6

    Protein attributes for RAB22A Gene

    Size:
    194 amino acids
    Molecular mass:
    21855 Da
    Quaternary structure:
    • Interacts directly with ZFYVE20 (By similarity). Binds EEA1 (By similarity). Interacts (in its GTP-bound form) with RABGEF1. Interacts (in its GTP-bound form) with RINL.

neXtProt entry for RAB22A Gene

Proteomics data for RAB22A Gene at MOPED

Post-translational modifications for RAB22A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB22A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RAB22A Gene

Domains for RAB22A Gene

Gene Families for RAB22A Gene

HGNC:
  • RAB :RAB, member RAS oncogene

Suggested Antigen Peptide Sequences for RAB22A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UL26

UniProtKB/Swiss-Prot:

RB22A_HUMAN :
  • Q9UL26
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB22A: view

Function for RAB22A Gene

Molecular function for RAB22A Gene

UniProtKB/Swiss-Prot Function: Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes. Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth. Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form.

Gene Ontology (GO) - Molecular Function for RAB22A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity TAS 11870209
GO:0005515 protein binding IPI 11870209
GO:0005525 GTP binding IMP 24466322
GO:0019003 GDP binding IDA 20937701
genes like me logo Genes that share ontologies with RAB22A: view

Phenotypes for RAB22A Gene

GenomeRNAi human phenotypes for RAB22A:
genes like me logo Genes that share phenotypes with RAB22A: view

Animal Model Products

CRISPR Products

miRNA for RAB22A Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAB22A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RAB22A Gene

Localization for RAB22A Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB22A Gene

Endosome membrane; Lipid-anchor. Cell membrane; Lipid-anchor. Early endosome. Cell projection, ruffle. Cytoplasmic vesicle. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB22A Gene COMPARTMENTS Subcellular localization image for RAB22A gene
Compartment Confidence
endosome 5
plasma membrane 5
cytosol 3
cytoskeleton 2
nucleus 2
vacuole 2
extracellular 1
golgi apparatus 1
lysosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RAB22A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IEA --
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005737 cytoplasm --
GO:0005769 early endosome IDA 11870209
genes like me logo Genes that share ontologies with RAB22A: view

Pathways for RAB22A Gene

genes like me logo Genes that share pathways with RAB22A: view

Pathways by source for RAB22A Gene

1 Qiagen pathway for RAB22A Gene
1 KEGG pathway for RAB22A Gene

Gene Ontology (GO) - Biological Process for RAB22A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport IBA --
GO:0006897 endocytosis IDA 11870209
GO:0006913 nucleocytoplasmic transport --
GO:0007032 endosome organization IEP 11870209
genes like me logo Genes that share ontologies with RAB22A: view

Transcripts for RAB22A Gene

mRNA/cDNA for RAB22A Gene

Unigene Clusters for RAB22A Gene

RAB22A, member RAS oncogene family:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAB22A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB22A Gene

No ASD Table

Relevant External Links for RAB22A Gene

GeneLoc Exon Structure for
RAB22A
ECgene alternative splicing isoforms for
RAB22A

Expression for RAB22A Gene

mRNA expression in normal human tissues for RAB22A Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB22A Gene

SOURCE GeneReport for Unigene cluster for RAB22A Gene Hs.529044

genes like me logo Genes that share expressions with RAB22A: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RAB22A Gene

Orthologs for RAB22A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAB22A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB22A 35
  • 98.75 (n)
  • 98.93 (a)
RAB22A 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RAB22A 35
  • 93.3 (n)
  • 97.94 (a)
RAB22A 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAB22A 35
  • 91.41 (n)
  • 98.45 (a)
RAB22A 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rab22a 35
  • 90.03 (n)
  • 97.42 (a)
Rab22a 16
Rab22a 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAB22A 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAB22A 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rab22a 35
  • 84.85 (n)
  • 87.7 (a)
chicken
(Gallus gallus)
Aves RAB22A 35
  • 86.08 (n)
  • 96.39 (a)
RAB22A 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAB22A 36
  • 96 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii Dr.15361 35
rab22a 35
  • 73.88 (n)
  • 87.63 (a)
rab22a 36
  • 87 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TEM1 38
VPS21 36
  • 39 (a)
ManyToMany
YPT53 36
  • 36 (a)
ManyToMany
Species with no ortholog for RAB22A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAB22A Gene

ENSEMBL:
Gene Tree for RAB22A (if available)
TreeFam:
Gene Tree for RAB22A (if available)

Paralogs for RAB22A Gene

Paralogs for RAB22A Gene

genes like me logo Genes that share paralogs with RAB22A: view

Variants for RAB22A Gene

Sequence variations from dbSNP and Humsavar for RAB22A Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs11052 -- 58,367,424(+) CTTTT(A/G)TAGAG utr-variant-3-prime
rs12650 -- 58,360,598(-) CATAA(A/G)TATAG utr-variant-3-prime
rs14856 -- 58,367,321(-) GAAAA(A/C)AAAAA utr-variant-3-prime
rs471661 -- 58,340,259(+) TTTGC(C/T)GTAAC intron-variant
rs472199 -- 58,314,764(+) taaac(C/G)cggga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB22A Gene

Variant ID Type Subtype PubMed ID
nsv828760 CNV Loss 20364138

Relevant External Links for RAB22A Gene

HapMap Linkage Disequilibrium report
RAB22A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB22A Gene

Disorders for RAB22A Gene

Relevant External Links for RAB22A

Genetic Association Database (GAD)
RAB22A
genes like me logo Genes that share disorders with RAB22A: view

No data available for UniProtKB/Swiss-Prot for RAB22A Gene

Publications for RAB22A Gene

  1. Expression of Rab small GTPases in epithelial Caco-2 cells: Rab21 is an apically located GTP-binding protein in polarised intestinal epithelial cells. (PMID: 10887961) Opdam F.J.M. … Fransen J.A.M. (Eur. J. Cell Biol. 2000) 3 4
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Rab22a regulates the sorting of transferrin to recycling endosomes. (PMID: 16537905) Magadan J.G. … Mayorga L.S. (Mol. Cell. Biol. 2006) 3 4

Products for RAB22A Gene

Sources for RAB22A Gene

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