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Aliases for RAB22A Gene

Aliases for RAB22A Gene

  • RAB22A, Member RAS Oncogene Family 2 3 5
  • Rab-22 3 4
  • Ras-Related Protein Rab-22A 3
  • GTP-Binding Protein RAB22A 3
  • RAB22 4

External Ids for RAB22A Gene

Previous GeneCards Identifiers for RAB22A Gene

  • GC20P056613
  • GC20P057523
  • GC20P057570
  • GC20P056318
  • GC20P056884
  • GC20P053667

Summaries for RAB22A Gene

Entrez Gene Summary for RAB22A Gene

  • The protein encoded by this gene is a member of the RAB family of small GTPases. The GTP-bound form of the encoded protein has been shown to interact with early-endosomal antigen 1, and may be involved in the trafficking of and interaction between endosomal compartments. [provided by RefSeq, Jul 2008]

GeneCards Summary for RAB22A Gene

RAB22A (RAB22A, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Metabolism of proteins. GO annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB31.

UniProtKB/Swiss-Prot for RAB22A Gene

  • Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes. Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth. Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form.

Gene Wiki entry for RAB22A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB22A Gene

Genomics for RAB22A Gene

Regulatory Elements for RAB22A Gene

Enhancers for RAB22A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F058268 0.4 ENCODE 24.6 -40.6 -40644 1.2 PKNOX1 ARNT RAD21 HSF1 RCOR1 FOS GATAD2B ELF1 NR2F2 MBD2 RAB22A PPP4R1L ANKRD60
GH20F058399 0.2 Ensembl 24.2 +89.9 89905 0.4 GTF2F1 CTCF PKNOX1 CEBPG RAD21 CTBP1 MTA3 GATA3 SCRT2 SMC3 RAB22A PPP4R1L VAPB APCDD1L-AS1
GH20F058360 0.5 ENCODE 13.5 +51.9 51856 1.1 ZFP64 SIN3A YBX1 FOS ZNF202 ZNF680 HCFC1 ZBTB11 ZHX2 GATAD2B LOC101927932 NELFCD RAB22A ENSG00000270951 PPP4R1L PIR40663 VAPB
GH20F058432 1 Ensembl ENCODE 13.4 +123.8 123813 2.4 RAD21 YY1 ZNF664 MTA3 GLIS2 HNF4G FOS FOSL2 MAZ ZNF362 VAPB RAB22A GNAS-AS1 APCDD1L-AS1
GH20F058209 0.4 ENCODE 13.4 -99.7 -99707 0.3 PKNOX1 ARID4B SIN3A DMAP1 ZNF48 ZNF2 ELK1 ZNF143 ZNF207 DEK RAB22A LOC101927932 ANKRD60 LOC105372694
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RAB22A on UCSC Golden Path with GeneCards custom track

Promoters for RAB22A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001666828 104 2801 CREB3L1 SIN3A YBX1 YY1 GLIS2 ELK1 KLF7 FOS SP3 YY2

Genomic Location for RAB22A Gene

Chromosome:
20
Start:
58,309,696 bp from pter
End:
58,367,507 bp from pter
Size:
57,812 bases
Orientation:
Plus strand

Genomic View for RAB22A Gene

Genes around RAB22A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB22A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB22A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB22A Gene

Proteins for RAB22A Gene

  • Protein details for RAB22A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UL26-RB22A_HUMAN
    Recommended name:
    Ras-related protein Rab-22A
    Protein Accession:
    Q9UL26
    Secondary Accessions:
    • B3KR86
    • E1P605
    • Q8TF12
    • Q9H4E6

    Protein attributes for RAB22A Gene

    Size:
    194 amino acids
    Molecular mass:
    21855 Da
    Quaternary structure:
    • Interacts directly with ZFYVE20 (By similarity). Binds EEA1 (By similarity). Interacts (in its GTP-bound form) with RABGEF1. Interacts (in its GTP-bound form) with RINL.

neXtProt entry for RAB22A Gene

Post-translational modifications for RAB22A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB22A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for RAB22A
  • Santa Cruz Biotechnology (SCBT) Antibodies for RAB22A

No data available for DME Specific Peptides for RAB22A Gene

Domains & Families for RAB22A Gene

Gene Families for RAB22A Gene

Protein Domains for RAB22A Gene

Suggested Antigen Peptide Sequences for RAB22A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UL26

UniProtKB/Swiss-Prot:

RB22A_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB22A: view

Function for RAB22A Gene

Molecular function for RAB22A Gene

UniProtKB/Swiss-Prot Function:
Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes. Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth. Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form.

Gene Ontology (GO) - Molecular Function for RAB22A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity TAS 11870209
GO:0005515 protein binding IPI 11870209
GO:0005525 GTP binding IMP 24466322
GO:0019003 GDP binding IDA 20937701
genes like me logo Genes that share ontologies with RAB22A: view
genes like me logo Genes that share phenotypes with RAB22A: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB22A Gene

Localization for RAB22A Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB22A Gene

Endosome membrane; Lipid-anchor. Cell membrane; Lipid-anchor. Early endosome. Late endosome. Cell projection, ruffle. Cytoplasmic vesicle. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis. {ECO:0000269 PubMed:21255211}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB22A Gene COMPARTMENTS Subcellular localization image for RAB22A gene
Compartment Confidence
endosome 5
extracellular 5
plasma membrane 5
cytoskeleton 4
cytosol 3
golgi apparatus 2
lysosome 2
nucleus 2
vacuole 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RAB22A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IEA --
GO:0005768 endosome IEA --
GO:0005769 early endosome IEA,IDA 11870209
GO:0005770 late endosome IEA --
GO:0005886 plasma membrane IEA,IDA 11870209
genes like me logo Genes that share ontologies with RAB22A: view

Pathways & Interactions for RAB22A Gene

genes like me logo Genes that share pathways with RAB22A: view

Pathways by source for RAB22A Gene

1 KEGG pathway for RAB22A Gene
1 Qiagen pathway for RAB22A Gene

Gene Ontology (GO) - Biological Process for RAB22A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006897 endocytosis IDA 11870209
GO:0007032 endosome organization IEP 11870209
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with RAB22A: view

No data available for SIGNOR curated interactions for RAB22A Gene

Transcripts for RAB22A Gene

mRNA/cDNA for RAB22A Gene

Unigene Clusters for RAB22A Gene

RAB22A, member RAS oncogene family:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB22A Gene

No ASD Table

Relevant External Links for RAB22A Gene

GeneLoc Exon Structure for
RAB22A
ECgene alternative splicing isoforms for
RAB22A

Expression for RAB22A Gene

mRNA expression in normal human tissues for RAB22A Gene

Protein differential expression in normal tissues from HIPED for RAB22A Gene

This gene is overexpressed in Brain (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RAB22A Gene



Protein tissue co-expression partners for RAB22A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RAB22A Gene:

RAB22A

SOURCE GeneReport for Unigene cluster for RAB22A Gene:

Hs.529044
genes like me logo Genes that share expression patterns with RAB22A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RAB22A Gene

Orthologs for RAB22A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAB22A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB22A 34 35
  • 98.75 (n)
oppossum
(Monodelphis domestica)
Mammalia RAB22A 35
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RAB22A 34 35
  • 93.3 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RAB22A 35
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAB22A 34 35
  • 91.41 (n)
mouse
(Mus musculus)
Mammalia Rab22a 34 16 35
  • 90.03 (n)
rat
(Rattus norvegicus)
Mammalia Rab22a 34
  • 84.85 (n)
chicken
(Gallus gallus)
Aves RAB22A 34 35
  • 86.08 (n)
lizard
(Anolis carolinensis)
Reptilia RAB22A 35
  • 96 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii rab22a 34 35
  • 73.88 (n)
Dr.15361 34
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS21 35
  • 39 (a)
ManyToMany
YPT53 35
  • 36 (a)
ManyToMany
TEM1 37
Species where no ortholog for RAB22A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAB22A Gene

ENSEMBL:
Gene Tree for RAB22A (if available)
TreeFam:
Gene Tree for RAB22A (if available)

Paralogs for RAB22A Gene

Variants for RAB22A Gene

Sequence variations from dbSNP and Humsavar for RAB22A Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs10222028 -- 58,336,559(+) ACTGG(G/T)AGGTT intron-variant
rs1045387 -- 58,366,219(+) CCTTC(A/G)CATAT utr-variant-3-prime
rs1045402 -- 58,366,672(+) GGCCA(C/G)TGTTA utr-variant-3-prime
rs1045408 -- 58,367,026(+) TATAA(A/T)AGCAT utr-variant-3-prime
rs1045461 -- 58,367,418(+) AATAC(A/C)CTTTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RAB22A Gene

Variant ID Type Subtype PubMed ID
nsv1055956 CNV gain 25217958
nsv476646 CNV novel sequence insertion 20440878
nsv828760 CNV loss 20364138

Variation tolerance for RAB22A Gene

Residual Variation Intolerance Score: 75.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.34; 7.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAB22A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAB22A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB22A Gene

Disorders for RAB22A Gene

Relevant External Links for RAB22A

Genetic Association Database (GAD)
RAB22A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAB22A

No disorders were found for RAB22A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB22A Gene

Publications for RAB22A Gene

  1. Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes. (PMID: 21255211) Seto S. … Koide Y. (Traffic 2011) 3 4 64
  2. Rab22a regulates the sorting of transferrin to recycling endosomes. (PMID: 16537905) Magadan J.G. … Mayorga L.S. (Mol. Cell. Biol. 2006) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64

Products for RAB22A Gene

Sources for RAB22A Gene

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