RAB22A Gene
protein-coding GIFtS: 55
GCID: GC20P056884
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|
RAB22A, member RAS oncogene family
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Aliases
for RAB22A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| RAB22A, Member RAS Oncogene Family1 2 | | GTP-Binding Protein RAB22A2 | | Rab-223 | | Ras-Related Protein Rab-22A2 | | RAB223 | | Rab-223 |
Export aliases for RAB22A gene to outside databasesPrevious GC identifers: GC20P056613 GC20P057523 GC20P057570 GC20P056318 GC20P053667 |
Summaries
for RAB22A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RAB22A:
The protein encoded by this gene is a member of the RAB family of small GTPases. The GTP-bound form of the encodedprotein has been shown to interact with early-endosomal antigen 1, and may be involved in the trafficking of andinteraction between endosomal compartments. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: RB22A_HUMAN, Q9UL26Function: Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from earlyendosomes to recycling endosomes. Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth.Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactiveform
Gene Wiki entry for RAB22A
|
Genomic Views
for RAB22A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011362.10
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RAB22A gene promoter:
SRF AP-1 SRF (504 AA) Ik-3 c-Ets-1 CREB deltaCREB FOXO1a Pax-4a FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for RAB22A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB22A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20q13.32 Ensembl cytogenetic band: 20q13.32 HGNC cytogenetic band: 20q13RAB22A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20P056884: view genomic region
(about GC identifiers)
Start:
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56,884,752 bp from pter |
End:
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56,942,563 bp from pter |
Size:
|
57,812 bases |
Orientation:
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plus strand |
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Proteins
for RAB22A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RB22A_HUMAN, Q9UL26 (See
protein sequence)Recommended Name: Ras-related protein Rab-22A Size: 194 amino acids; 21855 Da
Subunit: Interacts directly with ZFYVE20 (By similarity). Binds EEA1 (By similarity). Interacts (in its GTP-bound form)with RABGEF1. Interacts (in its GTP-bound form) with RINL
Subcellular location: Endosome membrane; Lipid-anchor (By similarity). Cell membrane; Lipid-anchor (By similarity).Early endosome. Cell projection, ruffle. Cytoplasmic vesicle. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle,phagosome membrane; Lipid-anchor; Cytoplasmic side (By similarity). Note=Recruited to phagosomes containing S.aureusor M.tuberculosis
Secondary accessions: B3KR86 E1P605 Q8TF12 Q9H4E6Explore the universe of human proteins at neXtProt for RAB22A: NX_Q9UL26
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UL26
RAB22A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_065724.1
ENSEMBL proteins: ENSP00000244040
Human Recombinant Protein Products:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
RAB22A for ontologies About GeneDecksing
RAB22A Antibody Products:
Assay Products for RAB22A: |
Protein
Domains /
Families
for RAB22A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RAB22A for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UL26ProtoNet protein and cluster: Q9UL26 1 Blocks protein family: IPB001806 Transforming protein P21 RAS signature
UniProtKB/Swiss-Prot: RB22A_HUMAN, Q9UL26Similarity: Belongs to the small GTPase superfamily. Rab family |
Function
for RAB22A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RB22A_HUMAN, Q9UL26Function: Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from earlyendosomes to recycling endosomes. Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth.Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactiveform
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAB22A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB22A |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
RAB22A for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for RAB22A:
|
Pathways & Interactions
for RAB22A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Endocytosis | | | 2 | Sertoli-Sertoli Cell Junction Dynamics | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RAB22A
1 
Kegg Pathway (Kegg details for RAB22A):
RAB22A for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAB22A
STRING Interaction
Network Preview (showing 5 interactants - click image to see 10)
5/11 Interacting proteins for RAB22A (Q9UL261, 2, 3 ENSP000002440404) via UniProtKB, MINT, STRING, and/or I2D (see all 11)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
RAB22A for ontologies About GeneDecksing
|
Drugs & Compounds
for RAB22A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RAB22A
Search CenterWatch for drugs/clinical trials and news about RAB22A / RB22A
|
Transcripts
for RAB22A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RAB22A gene: NM_020673.2 Unigene Cluster for RAB22A: RAB22A, member RAS oncogene family Hs.529044 [show with all ESTs]Unigene Representative Sequence: NM_0206732 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000244040(uc002xyz.3) ENST00000488949
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAB22A (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAB22A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RAB22A (NM_020673) | | | DNA2.0 Custom Codon Optimized Gene
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Additional cDNA sequence: AF091034.2 AJ276210.1 AK054767.1 AK091180.1 BC007036.1 BC015710.1 BC016864.1 BC042545.1 BC063457.1 BT007046.1 7 DOTS entries: DT.87078920 DT.444701 DT.92438895 DT.100834909 DT.120800784 DT.75111983 DT.40202127 24/294 AceView cDNA sequences (see all 294): AA679966 AJ276210 AA457216 BU146346 AI308231 AA758198 BC063457 BU538226 AA195101 NM_020673 BG117302 AA978305 CD672277 AW467145 AA554316 AI914465 BF063561 BF431654 AI151183 F04725 AI672289 BQ004567 BM973886 AA195324
GeneLoc Exon Structure
|
Expression
for RAB22A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RAB22A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See RAB22A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RAB22A
SOURCE GeneReport for Unigene cluster: Hs.529044
SABiosciences Custom PCR Arrays for RAB22A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAB22A
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB22A |
Orthologs
for RAB22A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for RAB22A gene from 3/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
RAB22A1 |
RAB22A, member RAS oncogene family |
86.08(n)
96.39(a) |
|
419318 NM_001030867.1 NP_001026038.1 |
lizard
(Anolis carolinensis) |
Reptilia |
RAB22A6 |
-- |
96(a) |
1 ↔ 1 |
GL343217.1(125755-146826) |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.153612 |
Danio rerio clone RK113A4H10 RAB22A, member RAS oncogene more |
75.06(n) |
|
AY398404.1 |
ENSEMBL Gene Tree for RAB22A (if available)
TreeFam Gene Tree for RAB22A (if available) |
Paralogs
for RAB22A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RAB22A gene
- RAB5C2 RAB202 RAB312 ENSG000002672612 RAB5B2 RAB212 RAB5A2 RAB242
- RAB172
18/84 SIMAP similar genes for RAB22A using alignment to 1 protein entry: RB22A_HUMAN(see all similar genes):RAB31 RAB5C RAB5B RAB30 DKFZp686J07132 RAB5A
RAB11A RAB11B RAB39B RAB43 RAB8B RAB17
RAB12 RAB39A RAB6B RAB19 RAB21 RAB2A
RAB22A for paralogs About GeneDecksing
|
Genomic Variants
for RAB22A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RAB22A (56884752 - 56942563 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RAB22A: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAB22A |
|
Disorders
/ Diseases
for RAB22A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RAB22A for disorders About GeneDecksing
OMIM gene information: 612966
OMIM disorders: --
2  diseases for RAB22A: About MalaCardsinsulin resistance malaria
Export disorders for RAB22A gene to outside databases
|
Publications
for RAB22A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RAB22A gene, integrated from 9 sources (see all 23):
(articles sorted by number of sources associating them with RAB22A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Rab22a regulates the sorting of transferrin to recycling endosomes. (PubMed id 16537905)1, 2 Magadan J.G....Mayorga L.S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- Expression of Rab small GTPases in epithelial Caco-2 cells: Rab21 is an apically located GTP-binding protein in polarised intestinal epithelial cells. (PubMed id 10887961)1, 2 Opdam F.J.M....Fransen J.A.M. (2000)
- Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes. (PubMed id 21255211)2 Seto S.... Koide Y. (2011)
- Rin-like, a novel regulator of endocytosis, acts as guanine nucleotide exchange factor for Rab5a and Rab22. (PubMed id 21419809)2 Woller B.... Herbst R. (2011)
- Rab22 controls NGF signaling and neurite outgrowth in PC12 cells. (PubMed id 21849477)2 Wang L.... Li G. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- ErbB2-associated changes in the lysosomal proteome. (PubMed id 21674799)1 Nylandsted J....Jaattela M. (2011)
|
External Searches for RAB22A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RAB22A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RAB22A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RAB22A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for RAB22A gene:
Search GeneIP for patents involving RAB22A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RAB22A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RAB22A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAB22A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB22A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAB22A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAB22A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAB22A |
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|
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB22A |
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