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RAB22A Gene

protein-coding   GIFtS: 54

GC20P056318
RAB22A, member RAS oncogene family
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
MGC16770 2
OTTHUMP00000031397 2
RAB22 3
Rab-22 3
Descriptions
GTP-binding protein RAB22A 2
RAB22A, member RAS oncogene family 2
RAS-related protein RAB-22A 2
External Ids
HGNC: 97641
Entrez Gene: 574032
UniProtKB: Q9UL263
Ensembl: ENSG000001242097
Search outside databases for aliases for RAB22A gene

Previous GC identifers: GC20P056613 GC20P057523 GC20P057570

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for RAB22A:
The protein encoded by this gene is a member of the RAB family of small GTPases. The GTP-bound form
of the encoded protein has been shown to interact with early-endosomal antigen 1, and may be
involved in the trafficking of and interaction between endosomal compartments. [provided by
RefSeq]

Gene Wiki entry for RAB22A
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the RAB22A gene  

Entrez Gene cytogenetic band: 20q13.32   Ensembl cytogenetic band:  20q13.32   HGNC cytogenetic band: 20q13

RAB22A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P056318:     (about GC identifiers)

Start:
56,318,177 bp from pter
End:
56,375,969 bp from pter
Size:
57,793 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000020.9  NT_011362.9  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: RB22A_HUMAN, Q9UL26 (See protein sequence)
Recommended Name: Ras-related protein Rab-22A  
Size: 194 amino acids; 21855 Da
Subunit: Interacts directly with ZFYVE20 (By similarity). Binds EEA1 (By similarity)
Subcellular location: Endosome membrane; Lipid-anchor (By similarity). Cell membrane; Lipid-anchor
(By similarity)
Secondary accessions: Q8TF12 Q9H4E6

REFSEQ proteins: NP_065724.1  

ENSEMBL proteins: 
ENSP00000244040 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (RAB22A)
Human Recombinant Proteins from Abnova (RAB22A)
              OriGene Purified Recombinant Human Protein: RAB22A 

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005769 early endosome IDA11870209
GO:0005886 plasma membrane IDA11870209
GO:0010008 endosome membrane IEA--
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Antibodies for RAB22A: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Antibodies from Abcam (RAB22A), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (RAB22A)
Novus Biologicals Antibodies for RAB22A

Assays for RAB22A: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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5 InterPro domains/families:
 IPR015594 Rab22-like
 IPR001806 Ras_GTPase
 IPR005225 Small_GTP_bd
 IPR003579 GTPase_Rab
 IPR013753 Ras


   GeneDecks  RAB22A for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q9UL26

ProtoNet protein and cluster: Q9UL26

1 Blocks protein family: IPB001806 Transforming protein P21 RAS signature

UniProtKB/Swiss-Prot: RB22A_HUMAN, Q9UL26
Similarity: Belongs to the small GTPase superfamily. Rab family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (RAB22A)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (RAB22A)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_020673

              Applied Biosystems Silencer® siRNAs for RAB22A

              Sigma-Aldrich siRNA for RAB22A  
                     Sigma-Aldrich shRNA for RAB22A  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for RAB22A
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_020673
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_020673
                                 untagged cDNA clone in CMV expression vector: NM_020673 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_020673

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0000166 nucleotide binding IEA--
GO:0003924 GTPase activity TAS11870209
GO:0005515 protein binding NAS14613930
GO:0005525 GTP binding TAS11870209
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


 Gene Network CentralTM Interacting Genes and Proteins Network for  RAB22A 


4 Interacting proteins for RAB22A (ENSP000002440403 Q9UL261, 2) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
EEA1Q150751STRING (score=.827) EBI-399456, EBI-298113
APPL1Q9UKG12MINT-5204082
APPL2Q8NEU82MINT-67006
RABAC1ENSP000002220083STRING (score=.709)
About this table

4 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006897 endocytosis IDA11870209
GO:0007032 endosome organization IEP11870209
GO:0007264 small GTPase mediated signal transduction IEA--
GO:0015031 protein transport IEA--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for RAB22A
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for RAB22A

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (RAB22A)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (RAB22A)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_020673

              Sigma-Aldrich siRNA for RAB22A  
                     Sigma-Aldrich shRNA for RAB22A  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_020673  

REFSEQ mRNAs for RAB22A gene: 

NM_020673.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_020673  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_020673
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_020673
                                 untagged cDNA clone in CMV expression vector: NM_020673 

Additional cDNA sequence: 

AF091034.2 AJ276210.1 AK054767.1 AK091180.1 BC007036.1 BC015710.1 BC016864.1 BC042545.1 
BC063457.1 BT007046.1 CR610918.1 

7 DOTS entries:

DT.87078920  DT.444701  DT.92438895  DT.100834909  DT.120800784  DT.75111983  DT.40202127 

24/294 AceView cDNA sequences (see all 294 ):

F08512 BM972748 BM741391 AA195324 AW630305 CD672277 N73955 AA195101 
BQ004567 AA554316 AI271962 BM747961 BC015710 AI364410 NM_020673 AA679966 
BM767269 BG286261 F05105 BQ024280 AI672289 BU538226 F04725 CR610918 

highest scoring ESTs for RAB22A:

AA005414 AA025596 AA195489 AA199604 AA293036 AA293428 AA398963 AA452929 AA457216 AA522952 

Unigene Cluster for RAB22A:

RAB22A, member RAS oncogene family
Hs.529044  [show with all ESTs]
Unigene Representative Sequence: NM_020673


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000244040  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

RAB22A expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for RAB22A

1 / 2 / 3

6 probe-sets matching RAB22A gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

33716_at2, 3 U95-A 1 1.00 1.00 0.61 1.58 N95443 0.80 1.00 0.91 1

66330_at2, 3 U95-C 1 1.00 1.00 0.90 0.47 AL121369 0.80 1.00 0.91 1

213405_at2, 3 U133-A 1 1.00 1.00 -- -- N95443 0.80 1.00 0.91 1

218360_at2, 3 U133-A 1 1.00 1.00 -- -- NM_020673 0.60 1.00 0.82 1

213405_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

218360_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
About this table
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.529044

Expression variation in blood from EXPOLDB for RAB22A

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for RAB22A gene from 5/8 species (see all 8 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
RAB22A1   -- RAB22A, member RAS oncogene family 91.41(n)
98.45(a)
403864  NM_001003208.1  NP_001003208.1 
chimpanzee
(Pan troglodytes)
RAB22A1   -- RAB22A, member RAS oncogene family 99.82(n)
99.45(a)
736048  XM_001135766.1  XP_001135766.1 
cow
(Bos taurus)
RAB22A1   -- RAB22A, member RAS oncogene family 93.47(n)
98.45(a)
617385  XM_869634.2  XP_874727.2 
rat
(Rattus norvegicus)
Rab22a1   -- RAB22A, member RAS oncogene family 88.83(n)
96.39(a)
366265  XM_345479.3  XP_345480.3 
mouse
(Mus musculus)
Rab22a1, 5 2 (100.50 cM)5
RAB22A, member RAS oncogene family1, 5 89(n)1
95.36(a)1
193341  NM_024436.21  NP_077756.11 
 AA0729245  AB2326165  (see all 30)
About this table        Species with no ortholog for RAB22A

ENSEMBL Gene Tree for RAB22A
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for RAB22A gene
RAB312  RAB242  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/357 NCBI SNPs in RAB22A are shown (see all 357 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 161)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 20 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs9683241,2
A,C,F,H,O56371273(-) AAACAG/AGGACT 1 -- ut31 ese316Minor allele frequency- A:0.37MN EU EA WA NA 1524
rs22949701,2
A,C,F,H,O56371004(-) TTCTCC/TGAAAA 1 -- ut31 ese39Minor allele frequency- T:0.29EA EU WA NA 1940
rs9683231,2
A,C,F,H,O56371439(-) AGAGAA/CGTTCT 1 -- ut3119Minor allele frequency- C:0.36EA MN EU WA NA 3236
rs18837991,2
A,C,F,H56370153(+) CTCCAC/TGACAA 1 -- ut31 ese38Minor allele frequency- T:0.48EU EA WA NA 628
rs10453871,2
A,C,F,H56374681(+) CCTTCG/ACATAT 1 -- ut31 ese39Minor allele frequency- A:0.23MN EU EA WA 990
rs60262201,2
A,C,F,H56373559(+) ATATTC/ATAACA 1 -- ut3112Minor allele frequency- A:0.45EU EA WA NS NA 664
rs60262141,2
A,C,F,H56370277(+) CACCAA/CACCCA 1 -- ut31 ese34Minor allele frequency- C:0.46EU EA WA 412
rs7075571,2
A,C,F,H56375718(-) TACAGG/ACATCA 1 -- ut31 ese311Minor allele frequency- A:0.41MN EU EA WA NA 1206
rs61283271,2
A,C,F,H56375963(+) TTTACA/GAATAT 1 -- ut31 ese37Minor allele frequency- G:0.34EU EA WA NA 560
rs10454081,2
A,C,F,H56375488(+) TATAAA/TAGCAT 1 -- ut31 ese39Minor allele frequency- N:0.00MN EU EA WA NA 812
About this table

HapMap Linkage Disequilibrium images for RAB22A (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

  --

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/15 PubMed articles for RAB22A gene (see all 15 ):
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 57403 HGNC: 9764 AceView: RAB22A Ensembl:ENSG00000124209 euGenes: HUgn57403
ECgene: RAB22A H-InvDB: RAB22A
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

NameDescription
ATLAS Chromosomes in Cancer entry for RAB22A Genetics and Cytogenetics in Oncology and Haematology
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for RAB22A:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for RAB22A-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for RAB22A Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for RAB22A Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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 Recombinant & Natural Proteins  

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 Custom Service for Rabbit Pab from Full-length Protein
  
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 Recombinant Proteins
(RAB22A)
 Antibodies (RAB22A)
 Tagged/untagged cDNA clones
 Validated SYBR primer pairs
 Purified proteins from HEK293T cells
 Western blot validated antibodies
 shRNA in GFP-retroviral vector
 Search Tocris compounds for RAB22A




 Drugs for RAB22A
 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for RAB22A

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