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Aliases for RAB22A Gene

Aliases for RAB22A Gene

  • RAB22A, Member RAS Oncogene Family 2 3 5
  • Rab-22 3 4
  • Ras-Related Protein Rab-22A 3
  • GTP-Binding Protein RAB22A 3
  • RAB22 4

External Ids for RAB22A Gene

Previous GeneCards Identifiers for RAB22A Gene

  • GC20P056613
  • GC20P057523
  • GC20P057570
  • GC20P056318
  • GC20P056884
  • GC20P053667

Summaries for RAB22A Gene

Entrez Gene Summary for RAB22A Gene

  • The protein encoded by this gene is a member of the RAB family of small GTPases. The GTP-bound form of the encoded protein has been shown to interact with early-endosomal antigen 1, and may be involved in the trafficking of and interaction between endosomal compartments. [provided by RefSeq, Jul 2008]

GeneCards Summary for RAB22A Gene

RAB22A (RAB22A, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are RAB geranylgeranylation and Metabolism of proteins. GO annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB31.

UniProtKB/Swiss-Prot for RAB22A Gene

  • Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes. Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth. Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form.

Gene Wiki entry for RAB22A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB22A Gene

Genomics for RAB22A Gene

Regulatory Elements for RAB22A Gene

Enhancers for RAB22A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G058372 1.3 Ensembl ENCODE 11.5 +64.8 64791 4.2 HDGF ATF1 YBX1 ZNF48 TCF12 ZNF207 NFYC REST MIER2 ZNF592 RAB22A PPP4R1L ANKRD60 APCDD1L-AS1 APCDD1L VAPB PIR40663
GH20G058236 1.3 Ensembl ENCODE 11 -72.1 -72143 2.3 CREB3L1 SIN3A YBX1 ZNF48 ZBTB7B ZNF207 ZNF143 FOS SP5 MXD4 RAB22A PPP4R1L ANKRD60
GH20G058305 1.7 FANTOM5 ENCODE dbSUPER 7.1 -1.0 -1018 5.4 PKNOX1 FOXA2 CREB3L1 SIN3A YBX1 YY1 ZNF143 ZNF207 FOS SP3 RAB22A PPP4R1L STX16 ANKRD60
GH20G058339 1.1 Ensembl ENCODE 10 +33.2 33243 6.1 TBP NFIB SIN3A YBX1 BRCA1 ZBTB40 RFX5 GATA2 RCOR1 FOS RAB22A VAPB PIR40663
GH20G058268 0.9 ENCODE 11.4 -40.6 -40644 1.2 PKNOX1 ARNT RAD21 ZBTB7B TCF12 GATA2 HSF1 RCOR1 FOS ELF1 PPP4R1L RAB22A ANKRD60
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RAB22A on UCSC Golden Path with GeneCards custom track

Promoters for RAB22A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000139359 104 2001 ATF1 CREB3L1 SIN3A YY1 GLIS2 ELK1 FOS KLF7 SP3 SP5

Genomic Location for RAB22A Gene

Chromosome:
20
Start:
58,309,696 bp from pter
End:
58,367,507 bp from pter
Size:
57,812 bases
Orientation:
Plus strand

Genomic View for RAB22A Gene

Genes around RAB22A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB22A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB22A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB22A Gene

Proteins for RAB22A Gene

  • Protein details for RAB22A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UL26-RB22A_HUMAN
    Recommended name:
    Ras-related protein Rab-22A
    Protein Accession:
    Q9UL26
    Secondary Accessions:
    • B3KR86
    • E1P605
    • Q8TF12
    • Q9H4E6

    Protein attributes for RAB22A Gene

    Size:
    194 amino acids
    Molecular mass:
    21855 Da
    Quaternary structure:
    • Interacts directly with ZFYVE20 (By similarity). Binds EEA1 (By similarity). Interacts (in its GTP-bound form) with RABGEF1. Interacts (in its GTP-bound form) with RINL.

neXtProt entry for RAB22A Gene

Post-translational modifications for RAB22A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB22A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RAB22A Gene

Domains & Families for RAB22A Gene

Gene Families for RAB22A Gene

Protein Domains for RAB22A Gene

Suggested Antigen Peptide Sequences for RAB22A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UL26

UniProtKB/Swiss-Prot:

RB22A_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB22A: view

Function for RAB22A Gene

Molecular function for RAB22A Gene

UniProtKB/Swiss-Prot Function:
Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes. Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth. Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form.

Gene Ontology (GO) - Molecular Function for RAB22A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity TAS 11870209
GO:0005515 protein binding IPI 11870209
GO:0005525 GTP binding IMP 24466322
GO:0019003 GDP binding IDA 20937701
genes like me logo Genes that share ontologies with RAB22A: view
genes like me logo Genes that share phenotypes with RAB22A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB22A Gene

Localization for RAB22A Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB22A Gene

Endosome membrane; Lipid-anchor. Cell membrane; Lipid-anchor. Early endosome. Late endosome. Cell projection, ruffle. Cytoplasmic vesicle. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis. {ECO:0000269 PubMed:21255211}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB22A gene
Compartment Confidence
plasma membrane 5
extracellular 5
endosome 5
cytoskeleton 4
cytosol 3
nucleus 2
lysosome 2
golgi apparatus 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RAB22A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IEA --
GO:0005768 endosome IEA --
GO:0005769 early endosome IEA,IDA 11870209
GO:0005770 late endosome IEA --
GO:0005886 plasma membrane IDA,IEA 11870209
genes like me logo Genes that share ontologies with RAB22A: view

Pathways & Interactions for RAB22A Gene

genes like me logo Genes that share pathways with RAB22A: view

Pathways by source for RAB22A Gene

1 KEGG pathway for RAB22A Gene
1 Qiagen pathway for RAB22A Gene

Gene Ontology (GO) - Biological Process for RAB22A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006897 endocytosis IDA 11870209
GO:0007032 endosome organization IEP 11870209
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with RAB22A: view

No data available for SIGNOR curated interactions for RAB22A Gene

Drugs & Compounds for RAB22A Gene

No Compound Related Data Available

Transcripts for RAB22A Gene

mRNA/cDNA for RAB22A Gene

Unigene Clusters for RAB22A Gene

RAB22A, member RAS oncogene family:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB22A Gene

No ASD Table

Relevant External Links for RAB22A Gene

GeneLoc Exon Structure for
RAB22A
ECgene alternative splicing isoforms for
RAB22A

Expression for RAB22A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAB22A Gene

Protein differential expression in normal tissues from HIPED for RAB22A Gene

This gene is overexpressed in Brain (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RAB22A Gene



Protein tissue co-expression partners for RAB22A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RAB22A Gene:

RAB22A

SOURCE GeneReport for Unigene cluster for RAB22A Gene:

Hs.529044

Evidence on tissue expression from TISSUES for RAB22A Gene

  • Intestine(4.2)
  • Nervous system(3.4)
genes like me logo Genes that share expression patterns with RAB22A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAB22A Gene

Orthologs for RAB22A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAB22A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB22A 34 35
  • 98.75 (n)
oppossum
(Monodelphis domestica)
Mammalia RAB22A 35
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RAB22A 34 35
  • 93.3 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RAB22A 35
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAB22A 34 35
  • 91.41 (n)
mouse
(Mus musculus)
Mammalia Rab22a 34 16 35
  • 90.03 (n)
rat
(Rattus norvegicus)
Mammalia Rab22a 34
  • 84.85 (n)
chicken
(Gallus gallus)
Aves RAB22A 34 35
  • 86.08 (n)
lizard
(Anolis carolinensis)
Reptilia RAB22A 35
  • 96 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii rab22a 34 35
  • 73.88 (n)
Dr.15361 34
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS21 35
  • 39 (a)
ManyToMany
YPT53 35
  • 36 (a)
ManyToMany
TEM1 37
Species where no ortholog for RAB22A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAB22A Gene

ENSEMBL:
Gene Tree for RAB22A (if available)
TreeFam:
Gene Tree for RAB22A (if available)

Paralogs for RAB22A Gene

Variants for RAB22A Gene

Sequence variations from dbSNP and Humsavar for RAB22A Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000107430 -- 58,323,175(+) TGTTA(C/T)GGACT intron-variant
rs1000184862 -- 58,355,716(+) CCACT(C/T)GGGAA intron-variant
rs1000228774 -- 58,335,177(+) AATCC(A/G)AGGAC intron-variant
rs1000387809 -- 58,341,644(+) TTAGA(C/T)TTAAT intron-variant
rs1000394666 -- 58,342,024(+) CTTTA(-/AAT)AATAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB22A Gene

Variant ID Type Subtype PubMed ID
nsv1055956 CNV gain 25217958
nsv476646 CNV novel sequence insertion 20440878
nsv828760 CNV loss 20364138

Variation tolerance for RAB22A Gene

Residual Variation Intolerance Score: 75.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.34; 7.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAB22A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAB22A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB22A Gene

Disorders for RAB22A Gene

Relevant External Links for RAB22A

Genetic Association Database (GAD)
RAB22A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAB22A

No disorders were found for RAB22A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB22A Gene

Publications for RAB22A Gene

  1. Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes. (PMID: 21255211) Seto S. … Koide Y. (Traffic 2011) 3 4 64
  2. Rab22a regulates the sorting of transferrin to recycling endosomes. (PMID: 16537905) Magadan J.G. … Mayorga L.S. (Mol. Cell. Biol. 2006) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64

Products for RAB22A Gene

Sources for RAB22A Gene

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