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Aliases for RAB22A Gene

Aliases for RAB22A Gene

  • RAB22A, Member RAS Oncogene Family 2 3 5
  • Rab-22 3 4
  • Ras-Related Protein Rab-22A 3
  • GTP-Binding Protein RAB22A 3
  • RAB22 4

External Ids for RAB22A Gene

Previous GeneCards Identifiers for RAB22A Gene

  • GC20P056613
  • GC20P057523
  • GC20P057570
  • GC20P056318
  • GC20P056884
  • GC20P053667

Summaries for RAB22A Gene

Entrez Gene Summary for RAB22A Gene

  • The protein encoded by this gene is a member of the RAB family of small GTPases. The GTP-bound form of the encoded protein has been shown to interact with early-endosomal antigen 1, and may be involved in the trafficking of and interaction between endosomal compartments. [provided by RefSeq, Jul 2008]

GeneCards Summary for RAB22A Gene

RAB22A (RAB22A, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and RAB geranylgeranylation. Gene Ontology (GO) annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB31.

UniProtKB/Swiss-Prot for RAB22A Gene

  • Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes (PubMed:16537905). Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth (PubMed:21849477). Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form (PubMed:16537905).

Gene Wiki entry for RAB22A Gene

Additional gene information for RAB22A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB22A Gene

Genomics for RAB22A Gene

GeneHancer (GH) Regulatory Elements for RAB22A Gene

Promoters and enhancers for RAB22A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I058305 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 557.2 -1.0 -1018 5.4 PKNOX1 FOXA2 SMAD1 SIN3A YBX1 YY1 ZNF213 ZNF207 ZNF143 FOS RAB22A PPP4R1L NELFCD RAE1 LOC101927932 STX16 ANKRD60
GH20I058372 Enhancer 1.2 Ensembl ENCODE 11.5 +64.8 64790 4.2 HDGF ATF1 SIN3A ZNF48 ETS1 TCF12 ZNF207 ZNF143 RXRA MIER2 PPP4R1L RAB22A ANKRD60 APCDD1L APCDD1L-AS1 ENSG00000254419 VAPB PIR40663
GH20I058236 Enhancer 1.2 Ensembl ENCODE 11 -72.1 -72143 2.3 CLOCK NEUROD1 SIN3A YBX1 ZBTB7B ZNF48 E2F8 ZNF207 ZNF143 FOS PPP4R1L RAE1 RAB22A ENSG00000254419 ANKRD60
GH20I058268 Enhancer 0.8 ENCODE 11.4 -40.6 -40644 1.2 HDAC1 PKNOX1 ARNT NEUROD1 ZBTB7B ZBTB40 TCF12 FOS RCOR1 GATAD2B PPP4R1L RAB22A ENSG00000254419 ANKRD60
GH20I058420 Enhancer 0.7 ENCODE 10.9 +111.1 111059 0.8 CEBPG FOSL1 ZNF664 CBFA2T2 FOSL2 FOS PRDM10 CEBPB CBFA2T3 DPF2 PPP4R1L RAB22A VAPB APCDD1L-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RAB22A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RAB22A gene promoter:

Genomic Locations for RAB22A Gene

Genomic Locations for RAB22A Gene
chr20:58,309,696-58,367,507
(GRCh38/hg38)
Size:
57,812 bases
Orientation:
Plus strand
chr20:56,884,752-56,942,563
(GRCh37/hg19)

Genomic View for RAB22A Gene

Genes around RAB22A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB22A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB22A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB22A Gene

Proteins for RAB22A Gene

  • Protein details for RAB22A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UL26-RB22A_HUMAN
    Recommended name:
    Ras-related protein Rab-22A
    Protein Accession:
    Q9UL26
    Secondary Accessions:
    • B3KR86
    • E1P605
    • Q8TF12
    • Q9H4E6

    Protein attributes for RAB22A Gene

    Size:
    194 amino acids
    Molecular mass:
    21855 Da
    Quaternary structure:
    • Interacts directly with ZFYVE20 (By similarity). Binds EEA1 (By similarity). Interacts (in its GTP-bound form) with RABGEF1 (PubMed:21849477). Interacts (in its GTP-bound form) with RINL (PubMed:21419809).

neXtProt entry for RAB22A Gene

Post-translational modifications for RAB22A Gene

No Post-translational modifications

Other Protein References for RAB22A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RAB22A Gene

Domains & Families for RAB22A Gene

Gene Families for RAB22A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RAB22A Gene

Suggested Antigen Peptide Sequences for RAB22A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UL26

UniProtKB/Swiss-Prot:

RB22A_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB22A: view

Function for RAB22A Gene

Molecular function for RAB22A Gene

UniProtKB/Swiss-Prot Function:
Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes (PubMed:16537905). Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth (PubMed:21849477). Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form (PubMed:16537905).

Phenotypes From GWAS Catalog for RAB22A Gene

Gene Ontology (GO) - Molecular Function for RAB22A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity TAS 11870209
GO:0005515 protein binding IPI 11870209
GO:0005525 GTP binding IMP 24466322
GO:0019003 GDP binding IDA 20937701
genes like me logo Genes that share ontologies with RAB22A: view
genes like me logo Genes that share phenotypes with RAB22A: view

miRNA for RAB22A Gene

miRTarBase miRNAs that target RAB22A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB22A Gene

Localization for RAB22A Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB22A Gene

Endosome membrane; Lipid-anchor. Cell membrane; Lipid-anchor. Early endosome. Late endosome. Cell projection, ruffle. Cytoplasmic vesicle. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis. {ECO:0000269 PubMed:21255211}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB22A gene
Compartment Confidence
plasma membrane 5
extracellular 5
endosome 5
cytoskeleton 4
cytosol 3
nucleus 2
golgi apparatus 2
mitochondrion 1
peroxisome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RAB22A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IEA --
GO:0005768 endosome IEA --
GO:0005769 early endosome IEA,IDA 11870209
GO:0005770 late endosome IEA --
GO:0005886 plasma membrane IEA,IDA 11870209
genes like me logo Genes that share ontologies with RAB22A: view

Pathways & Interactions for RAB22A Gene

genes like me logo Genes that share pathways with RAB22A: view

Pathways by source for RAB22A Gene

1 KEGG pathway for RAB22A Gene
1 Qiagen pathway for RAB22A Gene

Gene Ontology (GO) - Biological Process for RAB22A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006897 endocytosis IEA,IDA 11870209
GO:0007032 endosome organization IEP 11870209
GO:0015031 protein transport IEA --
GO:0097494 regulation of vesicle size IMP 24466322
genes like me logo Genes that share ontologies with RAB22A: view

No data available for SIGNOR curated interactions for RAB22A Gene

Drugs & Compounds for RAB22A Gene

No Compound Related Data Available

Transcripts for RAB22A Gene

mRNA/cDNA for RAB22A Gene

Unigene Clusters for RAB22A Gene

RAB22A, member RAS oncogene family:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAB22A Gene

No ASD Table

Relevant External Links for RAB22A Gene

GeneLoc Exon Structure for
RAB22A
ECgene alternative splicing isoforms for
RAB22A

Expression for RAB22A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAB22A Gene

Protein differential expression in normal tissues from HIPED for RAB22A Gene

This gene is overexpressed in Brain (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RAB22A Gene



Protein tissue co-expression partners for RAB22A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RAB22A Gene:

RAB22A

SOURCE GeneReport for Unigene cluster for RAB22A Gene:

Hs.529044

Evidence on tissue expression from TISSUES for RAB22A Gene

  • Intestine(4.2)
  • Nervous system(3.4)
genes like me logo Genes that share expression patterns with RAB22A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAB22A Gene

Orthologs for RAB22A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAB22A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB22A 33 34
  • 98.75 (n)
oppossum
(Monodelphis domestica)
Mammalia RAB22A 34
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RAB22A 33 34
  • 93.3 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RAB22A 34
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAB22A 33 34
  • 91.41 (n)
mouse
(Mus musculus)
Mammalia Rab22a 33 16 34
  • 90.03 (n)
rat
(Rattus norvegicus)
Mammalia Rab22a 33
  • 84.85 (n)
chicken
(Gallus gallus)
Aves RAB22A 33 34
  • 86.08 (n)
lizard
(Anolis carolinensis)
Reptilia RAB22A 34
  • 96 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii rab22a 33 34
  • 73.88 (n)
Dr.15361 33
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS21 34
  • 39 (a)
ManyToMany
YPT53 34
  • 36 (a)
ManyToMany
TEM1 36
Species where no ortholog for RAB22A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAB22A Gene

ENSEMBL:
Gene Tree for RAB22A (if available)
TreeFam:
Gene Tree for RAB22A (if available)

Paralogs for RAB22A Gene

Variants for RAB22A Gene

Sequence variations from dbSNP and Humsavar for RAB22A Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000107430 -- 58,323,175(+) T/C intron_variant
rs1000184862 -- 58,355,716(+) C/T intron_variant
rs1000228774 -- 58,335,177(+) A/G intron_variant
rs1000387809 -- 58,341,644(+) T/C intron_variant
rs1000394666 -- 58,342,024(+) AATAATAATAATAATA/AATAATAATAATA intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RAB22A Gene

Variant ID Type Subtype PubMed ID
nsv1055956 CNV gain 25217958
nsv476646 CNV novel sequence insertion 20440878
nsv828760 CNV loss 20364138

Variation tolerance for RAB22A Gene

Residual Variation Intolerance Score: 75.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.34; 7.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RAB22A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAB22A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB22A Gene

Disorders for RAB22A Gene

Additional Disease Information for RAB22A

No disorders were found for RAB22A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB22A Gene

Publications for RAB22A Gene

  1. Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes. (PMID: 21255211) Seto S … Koide Y (Traffic (Copenhagen, Denmark) 2011) 3 4 58
  2. Rab22a regulates the sorting of transferrin to recycling endosomes. (PMID: 16537905) Magadán JG … Mayorga LS (Molecular and cellular biology 2006) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58

Products for RAB22A Gene

Sources for RAB22A Gene

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