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Aliases for RAB21 Gene

Aliases for RAB21 Gene

  • RAB21, Member RAS Oncogene Family 2 3 5
  • KIAA0118 4

External Ids for RAB21 Gene

Previous GeneCards Identifiers for RAB21 Gene

  • GC12P071929
  • GC12P072100
  • GC12P070434
  • GC12P069197

Summaries for RAB21 Gene

Entrez Gene Summary for RAB21 Gene

  • This gene belongs to the Rab family of monomeric GTPases, which are involved in the control of cellular membrane traffic. The encoded protein plays a role in the targeted trafficking of integrins via its association with integrin alpha tails. As a consequence, the encoded protein is involved in the regulation of cell adhesion and migration. Expression of this gene is associated with a poor prognosis for glioma patients. This gene is downregulated by the tumor suppressor miR-200b, and miRNA-200b is itself downregulated in glioma tissues. [provided by RefSeq, Nov 2015]

GeneCards Summary for RAB21 Gene

RAB21 (RAB21, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB5C.

UniProtKB/Swiss-Prot for RAB21 Gene

  • Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general. As a result, may regulate cell adhesion and migration (By similarity). During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis. Involved in neurite growth (By similarity).

Gene Wiki entry for RAB21 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB21 Gene

Genomics for RAB21 Gene

Regulatory Elements for RAB21 Gene

Enhancers for RAB21 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F071780 0.6 ENCODE 12.1 +25.9 25855 1.1 CTCF ZNF654 TEAD4 SMC3 REST RAD21 TBC1D15 RAB21 TPH2 ENSG00000257410
GH12F071782 0.4 ENCODE 12.1 +27.5 27490 0.5 IKZF1 JUNB TBC1D15 RAB21 TPH2 ENSG00000257410
GH12F071754 1.1 ENCODE 0.8 +0.6 627 2.8 HDGF ARID4B SIN3A DMAP1 YY1 ZNF207 FOS DEK SP3 SP5 RAB21 ENSG00000257410
GH12F071753 0.9 FANTOM5 0.8 -1.7 -1718 0.1 HDAC1 ATF1 ARNT TBL1XR1 CHAMP1 GATA2 BCLAF1 CREM NCOA1 CEBPB TMEM19 ZFC3H1 THAP2 ENSG00000212461 RAB21 ENSG00000257515
GH12F071731 1.3 FANTOM5 Ensembl ENCODE 0.3 -22.9 -22880 1.0 ELF3 DRAP1 CTCF SAP130 HLF PTRF MIER2 RAD21 KAT8 ZGPAT TMEM19 ZFC3H1 ENSG00000257515 RAB21
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RAB21 on UCSC Golden Path with GeneCards custom track

Promoters for RAB21 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001464801 850 3001 HDGF ARID4B SIN3A DMAP1 YY1 ZNF207 FOS DEK SP3 SP5

Genomic Location for RAB21 Gene

Chromosome:
12
Start:
71,754,850 bp from pter
End:
71,800,285 bp from pter
Size:
45,436 bases
Orientation:
Plus strand

Genomic View for RAB21 Gene

Genes around RAB21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB21 Gene

Proteins for RAB21 Gene

  • Protein details for RAB21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UL25-RAB21_HUMAN
    Recommended name:
    Ras-related protein Rab-21
    Protein Accession:
    Q9UL25
    Secondary Accessions:
    • Q14466
    • Q569H3

    Protein attributes for RAB21 Gene

    Size:
    225 amino acids
    Molecular mass:
    24348 Da
    Quaternary structure:
    • Interacts with the cytoplasmic tail of integrins ITGA1, ITGA2, ITGA5, ITGA6, ITGA11 and ITGB1 (By similarity). Interacts with RABGEF1 (via VPS9 domain). Interacts with ANKRD27 (PubMed:16525121, PubMed:18477474).

    Three dimensional structures from OCA and Proteopedia for RAB21 Gene

neXtProt entry for RAB21 Gene

Post-translational modifications for RAB21 Gene

  • Ubiquitination at Lys 157
  • Modification sites at PhosphoSitePlus

Other Protein References for RAB21 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for RAB21
  • Santa Cruz Biotechnology (SCBT) Antibodies for RAB21

No data available for DME Specific Peptides for RAB21 Gene

Domains & Families for RAB21 Gene

Gene Families for RAB21 Gene

Protein Domains for RAB21 Gene

Suggested Antigen Peptide Sequences for RAB21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UL25

UniProtKB/Swiss-Prot:

RAB21_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB21: view

Function for RAB21 Gene

Molecular function for RAB21 Gene

UniProtKB/Swiss-Prot Function:
Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general. As a result, may regulate cell adhesion and migration (By similarity). During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis. Involved in neurite growth (By similarity).

Gene Ontology (GO) - Molecular Function for RAB21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003924 GTPase activity IDA 16034420
GO:0005515 protein binding IPI 16525121
GO:0005525 GTP binding IMP 15561770
GO:0019003 GDP binding IDA 16034420
genes like me logo Genes that share ontologies with RAB21: view
genes like me logo Genes that share phenotypes with RAB21: view

Animal Models for RAB21 Gene

MGI Knock Outs for RAB21:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RAB21 Gene

Localization for RAB21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB21 Gene

Endoplasmic reticulum membrane; Lipid-anchor. Golgi apparatus, trans-Golgi network. Golgi apparatus membrane. Early endosome membrane. Cytoplasmic vesicle membrane. Cleavage furrow. Note=Colocalizes with ANKRD27 and VAMP7 in neurites (By similarity). In nonpolarized epithelial Caco-2 cells, found in the endoplasmic reticulum; in polarized cells, observed in vesicles in the apical cytoplasm (PubMed:10887961). During mitosis, in mid-telophase, localized in the ingressing cleavage furrow (PubMed:18804435). In late telophase, detected at the opposite poles of the daughter cells, in vesicles at the base of lamellipodia formed by the separating daughter cells (PubMed:18804435). {ECO:0000250 UniProtKB:P35282, ECO:0000269 PubMed:10887961, ECO:0000269 PubMed:18804435}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB21 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 5
golgi apparatus 5
endosome 5
endoplasmic reticulum 3
mitochondrion 1
lysosome 1

Gene Ontology (GO) - Cellular Components for RAB21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005768 endosome IDA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with RAB21: view

Pathways & Interactions for RAB21 Gene

genes like me logo Genes that share pathways with RAB21: view

Pathways by source for RAB21 Gene

Gene Ontology (GO) - Biological Process for RAB21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0008089 anterograde axonal transport IEA --
GO:0015031 protein transport IEA --
GO:0017157 regulation of exocytosis IDA 22705394
genes like me logo Genes that share ontologies with RAB21: view

No data available for SIGNOR curated interactions for RAB21 Gene

Transcripts for RAB21 Gene

Unigene Clusters for RAB21 Gene

RAB21, member RAS oncogene family:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB21 Gene

No ASD Table

Relevant External Links for RAB21 Gene

GeneLoc Exon Structure for
RAB21
ECgene alternative splicing isoforms for
RAB21

Expression for RAB21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RAB21 Gene

Protein differential expression in normal tissues from HIPED for RAB21 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RAB21 Gene



Protein tissue co-expression partners for RAB21 Gene

NURSA nuclear receptor signaling pathways regulating expression of RAB21 Gene:

RAB21

SOURCE GeneReport for Unigene cluster for RAB21 Gene:

Hs.524590

mRNA Expression by UniProt/SwissProt for RAB21 Gene:

Q9UL25-RAB21_HUMAN
Tissue specificity: Widely expressed. In jejunal tissue, predominantly expressed in the apical region of the epithelial cell layer of the villi, weak expression, if any, in the crypt epithelium. Capillary endothelium and some cell types in the lamina propria also show expression.
genes like me logo Genes that share expression patterns with RAB21: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RAB21 Gene

Orthologs for RAB21 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RAB21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB21 34 35
  • 99.4 (n)
cow
(Bos Taurus)
Mammalia RAB21 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAB21 34 35
  • 96.87 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 92 (a)
OneToMany
-- 35
  • 85 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Rab21 34
  • 91.27 (n)
mouse
(Mus musculus)
Mammalia Rab21 34 16 35
  • 90.59 (n)
chicken
(Gallus gallus)
Aves RAB21 34 35
  • 87.56 (n)
lizard
(Anolis carolinensis)
Reptilia RAB21 35
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rab21 34
  • 83.57 (n)
zebrafish
(Danio rerio)
Actinopterygii RAB21 35
  • 87 (a)
OneToOne
zgc:154045 34
  • 76.83 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG17515 36
  • 64 (a)
Rab21 34 35
  • 62.2 (n)
chrw 36
  • 39 (a)
worm
(Caenorhabditis elegans)
Secernentea rab-21 34 35
  • 55.39 (n)
rice
(Oryza sativa)
Liliopsida Os05g0341600 34
  • 57.55 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2167 35
  • 76 (a)
OneToOne
Species where no ortholog for RAB21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB21 Gene

ENSEMBL:
Gene Tree for RAB21 (if available)
TreeFam:
Gene Tree for RAB21 (if available)

Paralogs for RAB21 Gene

Variants for RAB21 Gene

Sequence variations from dbSNP and Humsavar for RAB21 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10467173 -- 71,769,897(+) GGCTT(C/T)TTCCT intron-variant
rs1060327 -- 71,786,777(+) TTTGC(C/T)TCTGT utr-variant-3-prime
rs10706881 -- 71,785,888(+) TTTTT(G/T)GTTTT utr-variant-3-prime
rs10784937 -- 71,765,686(+) TTTCC(C/T)AGCAC intron-variant
rs10879329 -- 71,753,736(+) TCCAG(C/T)AAATT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RAB21 Gene

Variant ID Type Subtype PubMed ID
nsv832451 CNV loss 17160897
nsv559329 CNV loss 21841781
esv3892218 CNV gain 25118596
esv3629916 CNV gain 21293372
esv3629915 CNV loss 21293372
esv35030 CNV gain 17911159
esv2759907 CNV gain 17122850
esv2658849 CNV deletion 23128226

Variation tolerance for RAB21 Gene

Residual Variation Intolerance Score: 55.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.05; 37.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAB21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAB21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB21 Gene

Disorders for RAB21 Gene

Relevant External Links for RAB21

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAB21

No disorders were found for RAB21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB21 Gene

Publications for RAB21 Gene

  1. Expression of Rab small GTPases in epithelial Caco-2 cells: Rab21 is an apically located GTP-binding protein in polarised intestinal epithelial cells. (PMID: 10887961) Opdam F.J.M. … Fransen J.A.M. (Eur. J. Cell Biol. 2000) 2 3 4 64
  2. Role of Varp, a Rab21 exchange factor and TI-VAMP/VAMP7 partner, in neurite growth. (PMID: 19745841) Burgo A. … Galli T. (EMBO Rep. 2009) 3 4 64
  3. Integrin trafficking regulated by Rab21 is necessary for cytokinesis. (PMID: 18804435) Pellinen T. … Ivaska J. (Dev. Cell 2008) 3 4 64
  4. Structural basis for Rab GTPase activation by VPS9 domain exchange factors. (PMID: 17450153) Delprato A. … Lambright D.G. (Nat. Struct. Mol. Biol. 2007) 3 4 64
  5. Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins. (PMID: 16754960) Pellinen T. … Ivaska J. (J. Cell Biol. 2006) 2 3 64

Products for RAB21 Gene

Sources for RAB21 Gene

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