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Aliases for RAB21 Gene

Aliases for RAB21 Gene

  • RAB21, Member RAS Oncogene Family 2 3
  • KIAA0118 4 6

External Ids for RAB21 Gene

Previous GeneCards Identifiers for RAB21 Gene

  • GC12P071929
  • GC12P072100
  • GC12P070434
  • GC12P069197

Summaries for RAB21 Gene

Entrez Gene Summary for RAB21 Gene

  • This gene belongs to the Rab family of monomeric GTPases, which are involved in the control of cellular membrane traffic. The encoded protein plays a role in the targeted trafficking of integrins via its association with integrin alpha tails. As a consequence, the encoded protein is involved in the regulation of cell adhesion and migration. [provided by RefSeq, Aug 2013]

GeneCards Summary for RAB21 Gene

RAB21 (RAB21, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB5C.

UniProtKB/Swiss-Prot for RAB21 Gene

  • Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general. As a result, may regulate cell adhesion and migration (By similarity). During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis. Involved in neurite growth (By similarity).

Gene Wiki entry for RAB21 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB21 Gene

Genomics for RAB21 Gene

Regulatory Elements for RAB21 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RAB21 Gene

Start:
71,754,874 bp from pter
End:
71,800,285 bp from pter
Size:
45,412 bases
Orientation:
Plus strand

Genomic View for RAB21 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAB21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB21 Gene

Proteins for RAB21 Gene

  • Protein details for RAB21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UL25-RAB21_HUMAN
    Recommended name:
    Ras-related protein Rab-21
    Protein Accession:
    Q9UL25
    Secondary Accessions:
    • Q14466
    • Q569H3

    Protein attributes for RAB21 Gene

    Size:
    225 amino acids
    Molecular mass:
    24348 Da
    Quaternary structure:
    • Interacts with the cytoplasmic tail of integrins ITGA1, ITGA2, ITGA5, ITGA6, ITGA11 and ITGB1 (By similarity). Interacts with RABGEF1 (via VPS9 domain). Interacts with ANKRD27 (PubMed:16525121, PubMed:18477474).

    Three dimensional structures from OCA and Proteopedia for RAB21 Gene

neXtProt entry for RAB21 Gene

Proteomics data for RAB21 Gene at MOPED

Post-translational modifications for RAB21 Gene

  • Ubiquitination at Lys157
  • Modification sites at PhosphoSitePlus

Other Protein References for RAB21 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RAB21 Gene

Domains for RAB21 Gene

Gene Families for RAB21 Gene

HGNC:
  • RAB :RAB, member RAS oncogene

Suggested Antigen Peptide Sequences for RAB21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UL25

UniProtKB/Swiss-Prot:

RAB21_HUMAN :
  • Q9UL25
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB21: view

Function for RAB21 Gene

Molecular function for RAB21 Gene

UniProtKB/Swiss-Prot Function: Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general. As a result, may regulate cell adhesion and migration (By similarity). During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis. Involved in neurite growth (By similarity).

Gene Ontology (GO) - Molecular Function for RAB21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IDA 16034420
GO:0005515 protein binding IPI 16525121
GO:0005525 GTP binding IMP 15561770
GO:0019003 GDP binding IDA 16034420
genes like me logo Genes that share ontologies with RAB21: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAB21

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RAB21 Gene

Localization for RAB21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB21 Gene

Endoplasmic reticulum membrane; Lipid-anchor. Golgi apparatus, trans-Golgi network. Golgi apparatus membrane. Early endosome membrane. Cytoplasmic vesicle membrane. Cleavage furrow. Note=Colocalizes with ANKRD27 and VAMP7 in neurites (By similarity). In nonpolarized epithelial Caco-2 cells, found in the endoplasmic reticulum; in polarized cells, observed in vesicles in the apical cytoplasm. During mitosis, in mid-telophase, localized in the ingressing cleavage furrow. In late telophase, detected at the opposite poles of the daughter cells, in vesicles at the base of lamellipodia formed by the separating daughter cells. {ECO:0000250 UniProtKB:P35282, ECO:0000250 UniProtKB:Q6AXT5}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB21 Gene COMPARTMENTS Subcellular localization image for RAB21 gene
Compartment Confidence
endoplasmic reticulum 5
endosome 5
golgi apparatus 5
cytosol 3
extracellular 2
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RAB21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005737 cytoplasm --
GO:0005768 endosome IDA --
GO:0005783 endoplasmic reticulum --
genes like me logo Genes that share ontologies with RAB21: view

Pathways for RAB21 Gene

genes like me logo Genes that share pathways with RAB21: view

Pathways by source for RAB21 Gene

1 Qiagen pathway for RAB21 Gene

Gene Ontology (GO) - Biological Process for RAB21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport IBA --
GO:0006913 nucleocytoplasmic transport --
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction --
genes like me logo Genes that share ontologies with RAB21: view

Transcripts for RAB21 Gene

Unigene Clusters for RAB21 Gene

RAB21, member RAS oncogene family:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAB21

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB21 Gene

No ASD Table

Relevant External Links for RAB21 Gene

GeneLoc Exon Structure for
RAB21
ECgene alternative splicing isoforms for
RAB21

Expression for RAB21 Gene

mRNA expression in normal human tissues for RAB21 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB21 Gene

SOURCE GeneReport for Unigene cluster for RAB21 Gene Hs.524590

mRNA Expression by UniProt/SwissProt for RAB21 Gene

Q9UL25-RAB21_HUMAN
Tissue specificity: Widely expressed. In jejunal tissue, predominantly expressed in the apical region of the epithelial cell layer of the villi, weak expression, if any, in the crypt epithelium. Capillary endothelium and some cell types in the lamina propria also show expression.
genes like me logo Genes that share expressions with RAB21: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for RAB21 Gene

Orthologs for RAB21 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RAB21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB21 35
  • 99.4 (n)
  • 99.55 (a)
RAB21 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RAB21 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAB21 35
  • 96.87 (n)
  • 99.06 (a)
RAB21 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rab21 35
  • 90.59 (n)
  • 98.09 (a)
Rab21 16
Rab21 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 85 (a)
OneToMany
-- 36
  • 92 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Rab21 35
  • 91.27 (n)
  • 97.14 (a)
chicken
(Gallus gallus)
Aves RAB21 35
  • 87.56 (n)
  • 96.17 (a)
RAB21 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAB21 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rab21 35
  • 83.57 (n)
  • 94.2 (a)
zebrafish
(Danio rerio)
Actinopterygii RAB21 36
  • 87 (a)
OneToOne
zgc:154045 35
  • 76.83 (n)
  • 88.57 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rab21 35
  • 62.2 (n)
  • 65.85 (a)
Rab21 36
  • 54 (a)
OneToOne
CG17515 37
  • 64 (a)
chrw 37
  • 39 (a)
worm
(Caenorhabditis elegans)
Secernentea rab-21 35
  • 55.39 (n)
  • 54.55 (a)
rab-21 36
  • 54 (a)
OneToOne
rice
(Oryza sativa)
Liliopsida Os05g0341600 35
  • 57.55 (n)
  • 52.24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2167 36
  • 76 (a)
OneToOne
Species with no ortholog for RAB21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB21 Gene

ENSEMBL:
Gene Tree for RAB21 (if available)
TreeFam:
Gene Tree for RAB21 (if available)

Paralogs for RAB21 Gene

genes like me logo Genes that share paralogs with RAB21: view

Variants for RAB21 Gene

Sequence variations from dbSNP and Humsavar for RAB21 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs328711 -- 71,776,418(+) GAGTG(A/G)TTGCC intron-variant
rs328712 -- 71,775,004(+) AACTA(C/T)ACATT intron-variant
rs328738 -- 71,785,274(-) AAAAA(A/T)TTTTT intron-variant
rs328739 -- 71,785,292(-) AGTGA(C/T)ATCAA intron-variant
rs328740 -- 71,785,387(-) CTCAC(G/T)AAAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB21 Gene

Variant ID Type Subtype PubMed ID
nsv832451 CNV Loss 17160897
dgv519e1 CNV Complex 17122850
esv2658849 CNV Deletion 23128226
nsv899244 CNV Gain 21882294
dgv1447n71 CNV Gain 21882294
esv35030 CNV Gain 17911159
essv4115 CNV CNV 17122850

Relevant External Links for RAB21 Gene

HapMap Linkage Disequilibrium report
RAB21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB21 Gene

Disorders for RAB21 Gene

No disorders were found for RAB21 Gene.

No data available for UniProtKB/Swiss-Prot for RAB21 Gene

Publications for RAB21 Gene

  1. Expression of Rab small GTPases in epithelial Caco-2 cells: Rab21 is an apically located GTP-binding protein in polarised intestinal epithelial cells. (PMID: 10887961) Opdam F.J.M. … Fransen J.A.M. (Eur. J. Cell Biol. 2000) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7788527) Nagase T. … Nomura N. (DNA Res. 1995) 3 4
  3. Evolution of the Rab family of small GTP-binding proteins. (PMID: 11697911) Pereira-Leal J.B. … Seabra M.C. (J. Mol. Biol. 2001) 2 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A role for the small GTPase Rab21 in the early endocytic pathway. (PMID: 15561770) Simpson J.C. … Jones A.T. (J. Cell Sci. 2004) 3 4

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