Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RAB21 Gene

protein-coding   GIFtS: 54
GCID: GC12P072100

RAB21, Member RAS Oncogene Family

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
RAB21, Member RAS Oncogene Family1 2
KIAA01183 5
Ras-Related Protein Rab-212

External Ids:    HGNC: 182631   Entrez Gene: 230112   Ensembl: ENSG000000803717   OMIM: 6123985   UniProtKB: Q9UL253   

Export aliases for RAB21 gene to outside databases

Previous GC identifers: GC12P071929 GC12P070434 GC12P069197


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RAB21 Gene:
This gene belongs to the Rab family of monomeric GTPases, which are involved in the control of cellular membrane
traffic. The encoded protein plays a role in the targeted trafficking of integrins via its association with
integrin alpha tails. As a consequence, the encoded protein is involved in the regulation of cell adhesion and
migration. (provided by RefSeq, Aug 2013)

GeneCards Summary for RAB21 Gene: 
RAB21 (RAB21, member RAS oncogene family) is a protein-coding gene. Diseases associated with RAB21 include insulin resistance, and among its related super-pathways are Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include GDP binding and GTP binding. An important paralog of this gene is RAB20.

UniProtKB/Swiss-Prot: RAB21_HUMAN, Q9UL25
Function: Regulates integrin internalization and recycling, but does not influence the traffic of endosomally
translocated receptors in general. As a result, may regulate cell adhesion and migration (By similarity). During
the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the
successful completion of cytokinesis

Gene Wiki entry for RAB21 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RAB21 gene promoter:
         Pax-2   Nkx3-1 v1   XBP-1   Pax-2a   NF-kappaB   C/EBPalpha   YY1   Nkx3-1 v2   NF-kappaB2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRAB21 promoter sequence
   Search SABiosciences Chromatin IP Primers for RAB21

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB21


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q21.1   Ensembl cytogenetic band:  12q21.1   HGNC cytogenetic band: 12q15

RAB21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAB21 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P072100:  view genomic region     (about GC identifiers)

Start:
72,148,654 bp from pter      End:
72,184,699 bp from pter
Size:
36,046 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RAB21_HUMAN, Q9UL25 (See protein sequence)
Recommended Name: Ras-related protein Rab-21 precursor  
Size: 225 amino acids; 24348 Da
Subunit: Interacts with the cytoplasmic tail of integrins ITGA1, ITGA2, ITGA5, ITGA6, ITGA11 and ITGB1 (By
similarity). Interacts with RABGEF1 (via VPS9 domain)
Subcellular location: Endoplasmic reticulum membrane; Lipid-anchor (By similarity). Golgi apparatus membrane.
Early endosome membrane. Cytoplasmic vesicle membrane. Cleavage furrow. Note=In nonpolarized epithelial Caco-2
cells, found in the endoplasmic reticulum; in polarized cells, observed in vesicles in the apical cytoplasm.
During mitosis, in mid-telophase, localized in the ingressing cleavage furrow. In late telophase, detected at the
opposite poles of the daughter cells, in vesicles at the base of lamellipodia formed by the separating daughter
cells
5 PDB 3D structures from and Proteopedia for RAB21:
1YZT (3D)        1YZU (3D)        1Z08 (3D)        1Z0I (3D)        2OT3 (3D)    
Secondary accessions: Q14466 Q569H3

Explore the universe of human proteins at neXtProt for RAB21: NX_Q9UL25

Explore proteomics data for RAB21 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UL25

  • RAB21 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RAB21 Protein Expression
    REFSEQ proteins: NP_055814.1  
    ENSEMBL proteins: 
     ENSP00000261263  

    Human Recombinant Protein Products for RAB21: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for RAB21
    OriGene Protein Over-expression Lysate for RAB21
    OriGene MassSpec for RAB21 
    OriGene Custom Protein Services for RAB21
    GenScript Custom Purified and Recombinant Proteins Services for RAB21
    Novus Biologicals RAB21 Proteins
    Novus Biologicals RAB21 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for RAB21
    Cloud-Clone Corp. Proteins for RAB21 

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005622intracellular ----
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0005768endosome IDA--

    RAB21 for ontologies           About GeneDecksing



    RAB21 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for RAB21
    OriGene Custom Antibody Services for RAB21
    GenScript Custom Superior Antibodies Services for RAB21
    Novus Biologicals RAB21 Antibodies
    Abcam antibodies for RAB21
    Cloud-Clone Corp. Antibodies for RAB21 
    ThermoFisher Antibodies for RAB21
    LSBio Antibodies in human, mouse, rat for RAB21 

    Assay Products for RAB21: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RAB21
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RAB21
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RAB21 
    Cloud-Clone Corp. CLIAs for RAB21


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RAB: RAB, member RAS oncogene

    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR003579 Small_GTPase_Rab_type
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q9UL25

    ProtoNet protein and cluster: Q9UL25

    1 Blocks protein domain: IPB001806 Transforming protein P21 RAS signature

    UniProtKB/Swiss-Prot: RAB21_HUMAN, Q9UL25
    Similarity: Belongs to the small GTPase superfamily. Rab family


    RAB21 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RAB21_HUMAN, Q9UL25
    Function: Regulates integrin internalization and recycling, but does not influence the traffic of endosomally
    translocated receptors in general. As a result, may regulate cell adhesion and migration (By similarity). During
    the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the
    successful completion of cytokinesis

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IDA16034420
    GO:0005515protein binding IPI17450153
    GO:0005525GTP binding IDA16034420
    GO:0019003GDP binding IDA16034420
         
    RAB21 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RAB21 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RAB21

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RAB21 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RAB21 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAB21
    8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate RAB21 (see all 34):
    hsa-miR-411* hsa-miR-3164 hsa-miR-562 hsa-miR-379* hsa-miR-429 hsa-miR-411 hsa-miR-507 hsa-miR-186
    SwitchGear 3'UTR luciferase reporter plasmidRAB21 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RAB21
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAB21

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RAB21
    Sirion Biotech Customized adenovirus for overexpression of RAB21

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for RAB21 (see all 7)
    OriGene ORF clones in mouse, rat for RAB21
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RAB21 (NM_014999)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAB21
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB21
    Sirion Biotech Customized lentivirus for stable overexpression of RAB21 
                         Customized lentivirus expression plasmids for stable overexpression of RAB21 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RAB21
    Search LifeMap BioReagents cell lines for RAB21
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB21


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RAB21 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions0.36

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RAB21
        Epithelial Tight Junctions


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RAB21

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/12 Interacting proteins for RAB21 (Q9UL252, 3 ENSP000002612634) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APPL1Q9UKG12, 3, ENSP000002882664MINT-5207865 MINT-5207834 MINT-5207897 MINT-5208028 MINT-5207964 MINT-5208076 MINT-5207996 MINT-5207916 MINT-5204063 MINT-5208044 MINT-5208060 I2D: score=1 STRING: ENSP00000288266
    ITGB1P055563, ENSP000003640944I2D: score=1 STRING: ENSP00000364094
    ANKRD27Q96NW43I2D: score=1 
    HLA-BP304803I2D: score=1 
    IKBKEQ141643I2D: score=1 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process IDA16034420
    GO:0006886intracellular protein transport ----
    GO:0006913nucleocytoplasmic transport ----
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction IEA--

    RAB21 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RAB21

    Search CenterWatch for drugs/clinical trials and news about RAB21

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RAB21 gene: 
    NM_014999.2  

    Unigene Cluster for RAB21:

    RAB21, member RAS oncogene family
    Hs.524590  [show with all ESTs]
    Unigene Representative Sequence: BC009109
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261263(uc001swt.3) ENST00000358546 ENST00000547246 ENST00000552686

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAB21
    8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate RAB21 (see all 34):
    hsa-miR-411* hsa-miR-3164 hsa-miR-562 hsa-miR-379* hsa-miR-429 hsa-miR-411 hsa-miR-507 hsa-miR-186
    SwitchGear 3'UTR luciferase reporter plasmidRAB21 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RAB21
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAB21
    Clone
    Products:
         
    OriGene clones in human, mouse for RAB21 (see all 7)
    OriGene ORF clones in mouse, rat for RAB21
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RAB21 (NM_014999)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAB21
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB21
    Sirion Biotech Customized lentivirus for stable overexpression of RAB21 
                         Customized lentivirus expression plasmids for stable overexpression of RAB21 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RAB21
    OriGene qSTAR qPCR primer pairs in human, mouse for RAB21
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RAB21
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAB21
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAB21

    Additional mRNA sequence: 

    AB075482.1 AF091035.1 BC009109.1 BC021901.1 BC092475.1 D42087.1 

    8 DOTS entries:

    DT.209481  DT.91922497  DT.97861767  DT.100826817  DT.65284362  DT.100680561  DT.75102206  DT.121206658 

    24/221 AceView cDNA sequences (see all 221):

    CR604873 BG287677 BF060662 AW338740 AI865386 BQ070188 AA419555 BU616494 
    BX119716 BF063415 AI423277 CR590140 BM978770 AI927636 AA693454 CD722746 
    CA941131 AA809320 BM893579 AW269639 AI274214 BQ437436 CR600765 AA922618 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RAB21 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAATGCAGAT
    RAB21 Expression
    About this image


    See RAB21 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RAB21

    SOURCE GeneReport for Unigene cluster: Hs.524590

    UniProtKB/Swiss-Prot: RAB21_HUMAN, Q9UL25
    Tissue specificity: Widely expressed. In jejunal tissue, predominantly expressed in the apical region of the
    epithelial cell layer of the villi, weak expression, if any, in the crypt epithelium. Capillary endothelium and
    some cell types in the lamina propria also show expression

        SABiosciences Custom PCR Arrays for RAB21
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RAB21
    OriGene qSTAR qPCR primer pairs in human, mouse for RAB21
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RAB21
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAB21
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAB21
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB21

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RAB21 gene from 8/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rab211 , 5 RAB21, member RAS oncogene family1, 5 90.2(n)1
    96.83(a)1
      10 (63.51 cM)5
    2163441  NM_024454.11  NP_077774.11 
     1152898635 
    chicken
    (Gallus gallus)
    Aves RAB211 RAB21, member RAS oncogene family 86.79(n)
    95.39(a)
      771383  XM_001233647.2  XP_001233648.1 
    lizard
    (Anolis carolinensis)
    Reptilia RAB216
    Uncharacterized protein
    83(a)
    1 ↔ 1
    5(38495983-38508940)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC060498.12   -- 81.76(n)    BC060498.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1540451 zgc:154045 76.74(n)
    88.37(a)
      767727  NM_001076665.1  NP_001070133.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG175153
    Rab211
    RAB small monomeric GTPase3
    CG17515-PA1
    64(a)
    (best of 2)3
    61.71(n)1
    64.88(a)1
      33551631  NM_001042856.21  NP_001036321.21 
    worm
    (Caenorhabditis elegans)
    Secernentea rab-211 Protein RAB-21 55.72(n)
    54.55(a)
      187932  NM_063453.2  NP_495854.1 
    rice
    (Oryza sativa)
    Liliopsida AK111385.12   -- 71.86(n)    AK111385.1 


    ENSEMBL Gene Tree for RAB21 (if available)
    TreeFam Gene Tree for RAB21 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RAB21 gene
    RAB202  RAB5C2  ENSG000002672612  RAB312  RAB5B2  RAB5A2  RAB242  RAB22A2  
    RAB172  
    18/86 SIMAP similar genes for RAB21 using alignment to 1 protein entry:     RAB21_HUMAN(see all similar genes):
    RAB5C    RAB19    RAB30    RAB24    DKFZp686J07132    RAB15
    RAB5B    RAB39B    RAB8B    RAB13    RAB3C    RAB8A
    RAB11A    RAB22A    RANP1    RAB43    RAB33B    RAB35

    RAB21 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/735 SNPs in RAB21 are shown (see all 735)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1482615831,2
    C--69195274(+) ATTATC/TCTTCT 1 -- us2k10--------
    rs664605181,2
    C--72005901(+) GCACG-/CACA  
     
    /CACACA
    CACAC
    2 -- int1 cds11NA 2
    rs171102471,2
    C,F--72146681(+) TCTTAC/TGAAAA 1 -- us2k13Minor allele frequency- T:0.01NA 142
    rs1850680481,2
    --72146725(+) ATCCCC/GAACTT 1 -- us2k10--------
    rs775543141,2
    F--72146902(+) ACTTTC/TTCCAG 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1462819331,2
    C--72146927(+) GCATGC/G/TTAAAT 1 -- us2k10--------
    rs1886361621,2
    --72146977(+) TGTTTC/TATCAA 1 -- us2k10--------
    rs634618601,2
    C--72147145(+) TTTTT-/TTTTTTTT/TT
    TTTTTTTTTTTTTT
    TTTTT
    1 -- us2k11NA 2
    rs1390809231,2
    --72147202(+) GCGATC/TTCGGC 1 -- us2k10--------
    rs1816931221,2
    --72147204(+) GATCTC/TGGCTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RAB21 (72148654 - 72184699 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for RAB21:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2658849CNV Deletion23128226
    nsv832451CNV Loss17160897
    dgv1447n71CNV Gain21882294
    nsv899244CNV Gain21882294
    esv35030CNV Gain17911159
    essv4115CNV CNV17122850
    dgv519e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RAB21
    DNA2.0 Custom Variant and Variant Library Synthesis for RAB21

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612398    OMIM disorders: --

    2 diseases for RAB21:    About MalaCards
    insulin resistance    


    RAB21 for disorders           About GeneDecksing


    Export disorders for RAB21 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RAB21 gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with RAB21)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression of Rab small GTPases in epithelial Caco-2 cells: Rab21 is an apically located GTP-binding protein in polarised intestinal epithelial cells. (PubMed id 10887961)1, 2, 3 Opdam F.J.M....Fransen J.A.M. (2000)
    2. Integrin trafficking regulated by Rab21 is necessary for cytokinesis. (PubMed id 18804435)1, 2 Pellinen T.... Ivaska J. (2008)
    3. Structural basis for Rab GTPase activation by VPS9 domain exchange factors. (PubMed id 17450153)1, 2 Delprato A. and Lambright D.G. (2007)
    4. Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins. (PubMed id 16754960)1, 3 Pellinen T....Ivaska J. (2006)
    5. Structural basis of family-wide Rab GTPase recognition by rabenosyn- 5. (PubMed id 16034420)1, 2 Eathiraj S.... Lambright D.G. (2005)
    6. A role for the small GTPase Rab21 in the early endocytic pathway. (PubMed id 15561770)1, 2 Simpson J.C.... Jones A.T. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Evolution of the Rab family of small GTP-binding proteins. (PubMed id 11697911)1, 3 Pereira-Leal J.B. and Seabra M.C. (2001)
    9. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7788527)1, 2 Nagase T....Kotani H. (1995)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23011 HGNC: 18263 AceView: RAB21 Ensembl:ENSG00000080371 euGenes: HUgn23011
    ECgene: RAB21 H-InvDB: RAB21

    (According to HUGE)
    About This Section
    HUGE: KIAA0118

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RAB21 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAB21 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RAB21 gene:
    Search GeneIP for patents involving RAB21

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for RAB21   OriGene RNAi products in human, mouse, rat for RAB21  
     OriGene qPCR primer pairs and template standards for RAB21   OriGene Protein Over-expression Lysate for RAB21  
     OriGene MassSpec something-or-other for RAB21   OriGene clones in human, mouse for RAB21  
     OriGene qSTAR qPCR primer pairs in human, mouse for RAB21   OriGene Purified Protein for RAB21  
     OriGene ORF clones in mouse, rat for RAB21   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RAB21   OriGene Custom Protein Services for RAB21  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RAB21
     QIAGEN SeqTarget long-range PCR primers for resequencing RAB21
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB21
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAB21
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAB21
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAB21
     GenScript Custom Purified and Recombinant Proteins Services for RAB21 GenScript cDNA clones with any tag delivered in your preferred vector for RAB21
     GenScript Custom Assay Services for RAB21 GenScript Custom Superior Antibodies Services for RAB21
     GenScript Custom overexpressing Cell Line Services for RAB21 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in RAB21 promoter
     Search Chromatin IP Primers for RAB21
     RT2 qPCR Primer Assay in human, mouse, rat RAB21
     Search GNC Networks for RAB21
     SABiosciences PCR Arrays including human, mouse, rat RAB21
     Search Tocris compounds for RAB21
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     RAB21 antibodies
     RAB21 proteins
     RAB21 lysates
     Antibodies for RAB21
     See all of Abcam's Antibodies, Kits and Proteins for RAB21
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for RAB21




     Proteins for RAB21
     Antibodies for RAB21
     ELISAs for RAB21
     CLIAs for RAB21
     Search LifeMap BioReagents cell lines for RAB21
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB21
     SwitchGear 3'UTR luciferase reporter plasmids for RAB21
     SwitchGear Promoter luciferase reporter plasmids for RAB21
     ThermoFisher Antibodies for RAB21
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB21
     inGenious Targeting Laboratory - Custom generated mouse model solutions for RAB21
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RAB21
    Customized:
     lentivirus for stable overexpression of RAB21
     lentivirus expression plasmids for stable overexpression of RAB21
     adenovirus for overexpression of RAB21
     LSBio Antibodies in human, mouse, rat for RAB21
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RAB21 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4