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RAB21 Gene

protein-coding   GIFtS: 56
GCID: GC12P072100

RAB21, Member RAS Oncogene Family

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RAB21, Member RAS Oncogene Family1 2
KIAA01183 5
Ras-Related Protein Rab-212

External Ids:    HGNC: 182631   Entrez Gene: 230112   Ensembl: ENSG000000803717   OMIM: 6123985   UniProtKB: Q9UL253   

Export aliases for RAB21 gene to outside databases

Previous GC identifers: GC12P071929 GC12P070434 GC12P069197


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RAB21 Gene:
This gene belongs to the Rab family of monomeric GTPases, which are involved in the control of cellular membrane
traffic. The encoded protein plays a role in the targeted trafficking of integrins via its association with
integrin alpha tails. As a consequence, the encoded protein is involved in the regulation of cell adhesion and
migration. (provided by RefSeq, Aug 2013)

GeneCards Summary for RAB21 Gene:
RAB21 (RAB21, member RAS oncogene family) is a protein-coding gene. Diseases associated with RAB21 include insulin resistance, and lymphoblastic leukemia. GO annotations related to this gene include GDP binding and GTP binding. An important paralog of this gene is RAB20.

UniProtKB/Swiss-Prot: RAB21_HUMAN, Q9UL25
Function: Regulates integrin internalization and recycling, but does not influence the traffic of endosomally
translocated receptors in general. As a result, may regulate cell adhesion and migration (By similarity). During
the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the
successful completion of cytokinesis

Gene Wiki entry for RAB21 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the RAB21 gene promoter:
         Pax-2   Nkx3-1 v1   XBP-1   Pax-2a   NF-kappaB   C/EBPalpha   YY1   Nkx3-1 v2   NF-kappaB2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRAB21 promoter sequence
   Search Chromatin IP Primers for RAB21

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RAB21


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q21.1   Ensembl cytogenetic band:  12q21.1   HGNC cytogenetic band: 12q15

RAB21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAB21 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P072100:  view genomic region     (about GC identifiers)

Start:
72,148,654 bp from pter      End:
72,184,699 bp from pter
Size:
36,046 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RAB21_HUMAN, Q9UL25 (See protein sequence)
Recommended Name: Ras-related protein Rab-21 precursor  
Size: 225 amino acids; 24348 Da
Subunit: Interacts with the cytoplasmic tail of integrins ITGA1, ITGA2, ITGA5, ITGA6, ITGA11 and ITGB1 (By
similarity). Interacts with RABGEF1 (via VPS9 domain)
5 PDB 3D structures from and Proteopedia for RAB21:
1YZT (3D)        1YZU (3D)        1Z08 (3D)        1Z0I (3D)        2OT3 (3D)    
Secondary accessions: Q14466 Q569H3

Explore the universe of human proteins at neXtProt for RAB21: NX_Q9UL25

Explore proteomics data for RAB21 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys157
  • Modification sites at PhosphoSitePlus

  • See RAB21 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055814.1  
    ENSEMBL proteins: 
     ENSP00000261263  

    RAB21 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RAB: RAB, member RAS oncogene

    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR003579 Small_GTPase_Rab_type
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q9UL25

    ProtoNet protein and cluster: Q9UL25

    1 Blocks protein domain: IPB001806 Transforming protein P21 RAS signature

    UniProtKB/Swiss-Prot: RAB21_HUMAN, Q9UL25
    Similarity: Belongs to the small GTPase superfamily. Rab family


    RAB21 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RAB21_HUMAN, Q9UL25
    Function: Regulates integrin internalization and recycling, but does not influence the traffic of endosomally
    translocated receptors in general. As a result, may regulate cell adhesion and migration (By similarity). During
    the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the
    successful completion of cytokinesis

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IDA16034420
    GO:0005515protein binding IPI17450153
    GO:0005525GTP binding IDA16034420
    GO:0019003GDP binding IDA16034420
         
    RAB21 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RAB21
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RAB21

    miRNA
    Products:
        
    miRTarBase miRNAs that target RAB21:
    hsa-mir-30a-5p (MIRT028612), hsa-mir-19b-3p (MIRT050640), hsa-let-7g-5p (MIRT046563), hsa-mir-15a-5p (MIRT000812), hsa-mir-128-3p (MIRT022089), hsa-mir-196a-5p (MIRT048278), hsa-mir-16-5p (MIRT000811), hsa-mir-877-3p (MIRT036969)

    Block miRNA regulation of human, mouse, rat RAB21 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RAB21 (see all 34):
    hsa-miR-411* hsa-miR-3164 hsa-miR-562 hsa-miR-379* hsa-miR-429 hsa-miR-411 hsa-miR-507 hsa-miR-186
    SwitchGear 3'UTR luciferase reporter plasmidRAB21 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RAB21

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    GenScript: all cDNA clones in your preferred vector: RAB21 (NM_014999)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB21

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB21


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RAB21_HUMAN, Q9UL25: Endoplasmic reticulum membrane; Lipid-anchor (By similarity). Golgi apparatus membrane.
    Early endosome membrane. Cytoplasmic vesicle membrane. Cleavage furrow. Note=In nonpolarized epithelial Caco-2
    cells, found in the endoplasmic reticulum; in polarized cells, observed in vesicles in the apical cytoplasm.
    During mitosis, in mid-telophase, localized in the ingressing cleavage furrow. In late telophase, detected at the
    opposite poles of the daughter cells, in vesicles at the base of lamellipodia formed by the separating daughter
    cells
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    endosome5
    golgi apparatus5
    cytosol3
    extracellular2
    mitochondrion1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005622intracellular ----
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0005768endosome IDA--

    RAB21 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RAB21 About    
    See pathways by source

    SuperPathContained pathways About
    1Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions0.36

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for RAB21
        Epithelial Tight Junctions


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RAB21
    Interactions:

        Search GeneGlobe Interaction Network for RAB21

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for RAB21 (Q9UL251, 2, 3 ENSP000002612634) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APPL1Q9UKG11, 2, 3, ENSP000002882664EBI-1056039,EBI-741243 MINT-5207865 MINT-5207834 MINT-5207897 MINT-5208028 MINT-5207964 MINT-5208076 MINT-5207996 MINT-5207916 MINT-5204063 MINT-5208044 MINT-5208060 I2D: score=1 STRING: ENSP00000288266
    ITGB1P055563, ENSP000003640944I2D: score=1 STRING: ENSP00000364094
    ANKRD27Q96NW43, ENSP000003042924I2D: score=1 STRING: ENSP00000304292
    HLA-BP304803I2D: score=1 
    IKBKEQ141643I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process IDA16034420
    GO:0006886intracellular protein transport ----
    GO:0006913nucleocytoplasmic transport ----
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction IEA--

    RAB21 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RAB21



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RAB21 gene: 
    NM_014999.2  

    Unigene Cluster for RAB21:

    RAB21, member RAS oncogene family
    Hs.524590  [show with all ESTs]
    Unigene Representative Sequence: BC009109
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261263(uc001swt.3) ENST00000358546 ENST00000547246 ENST00000552686

    miRNA
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    Block miRNA regulation of human, mouse, rat RAB21 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RAB21 (see all 34):
    hsa-miR-411* hsa-miR-3164 hsa-miR-562 hsa-miR-379* hsa-miR-429 hsa-miR-411 hsa-miR-507 hsa-miR-186
    SwitchGear 3'UTR luciferase reporter plasmidRAB21 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RAB21
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    OriGene qPCR primer pairs and template standards for RAB21
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RAB21
      QuantiTect SYBR Green Assays in human, mouse, rat RAB21
      QuantiFast Probe-based Assays in human, mouse, rat RAB21

    Additional mRNA sequence: 

    AB075482.1 AF091035.1 BC009109.1 BC021901.1 BC092475.1 D42087.1 

    8 DOTS entries:

    DT.209481  DT.91922497  DT.97861767  DT.100826817  DT.65284362  DT.100680561  DT.75102206  DT.121206658 

    Selected AceView cDNA sequences (see all 221):

    BQ437436 BX499957 BM893579 CK430593 CR600765 AI423277 AI304549 D42087 
    AA922618 CD640776 AW338740 BE547884 AI927636 BQ070188 AA809320 CR604873 
    BX117131 BC021901 BM978770 CA314817 CR590140 BX119716 BP382887 CA866159 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RAB21 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAATGCAGAT
    RAB21 Expression
    About this image


    RAB21 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    RAB21 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RAB21 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.524590

    UniProtKB/Swiss-Prot: RAB21_HUMAN, Q9UL25
    Tissue specificity: Widely expressed. In jejunal tissue, predominantly expressed in the apical region of the
    epithelial cell layer of the villi, weak expression, if any, in the crypt epithelium. Capillary endothelium and
    some cell types in the lamina propria also show expression

        Custom PCR Arrays for RAB21
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB21

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RAB21 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rab211 , 5 RAB21, member RAS oncogene family1, 5 90.59(n)1
    98.09(a)1
      10 (63.51 cM)5
    2163441  NM_024454.11  NP_077774.11 
     1152898635 
    chicken
    (Gallus gallus)
    Aves RAB211 RAB21, member RAS oncogene family 87.56(n)
    96.17(a)
      771383  XM_001233647.3  XP_001233648.1 
    lizard
    (Anolis carolinensis)
    Reptilia RAB216
    RAB21, member RAS oncogene family
    85(a)
    1 ↔ 1
    5(38495983-38508940)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC060498.12   -- 81.76(n)    BC060498.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1540451 zgc:154045 76.83(n)
    88.57(a)
      767727  NM_001076665.1  NP_001070133.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG175153
    Rab211
    RAB small monomeric GTPase3
    Rab211
    64(a)
    (best of 2)3
    62.2(n)1
    65.85(a)1
      33551631  NM_001272856.11  NP_001259785.11 
    worm
    (Caenorhabditis elegans)
    Secernentea rab-211 rab-21 55.39(n)
    54.55(a)
      187932  NM_063453.3  NP_495854.1 
    rice
    (Oryza sativa)
    Liliopsida AK111385.12   -- 71.86(n)    AK111385.1 


    ENSEMBL Gene Tree for RAB21 (if available)
    TreeFam Gene Tree for RAB21 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RAB21 gene
    RAB202  RAB5C2  ENSG000002672612  RAB312  RAB5B2  RAB5A2  RAB242  RAB22A2  
    RAB172  
    Selected SIMAP similar genes for RAB21 using alignment to 1 protein entry:     RAB21_HUMAN(see all similar genes):
    RAB5C    RAB19    RAB30    RAB24    DKFZp686J07132    RAB15
    RAB5B    RAB39B    RAB8B    RAB13    RAB3C    RAB8A
    RAB11A    RAB22A    RANP1    RAB43    RAB33B    RAB35

    RAB21 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RAB21 (see all 735)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1482615831,2
    C--69195274(+) ATTATC/TCTTCT 1 -- us2k10--------
    rs664605181,2
    C--72005901(+) GCACG-/CACA  
     
    /CACACA
    CACAC
    2 -- int1 cds11NA 2
    rs171102471,2
    C,F--72146681(+) TCTTAC/TGAAAA 1 -- us2k13Minor allele frequency- T:0.01NA 142
    rs1850680481,2
    --72146725(+) ATCCCC/GAACTT 1 -- us2k10--------
    rs775543141,2
    F--72146902(+) ACTTTC/TTCCAG 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1462819331,2
    C--72146927(+) GCATGC/G/TTAAAT 1 -- us2k10--------
    rs1886361621,2
    --72146977(+) TGTTTC/TATCAA 1 -- us2k10--------
    rs634618601,2
    C--72147145(+) TTTTT-/TTTTTTTT/TT
    TTTTTTTTTTTTTT
    TTTTT
    1 -- us2k11NA 2
    rs1390809231,2
    --72147202(+) GCGATC/TTCGGC 1 -- us2k10--------
    rs1816931221,2
    --72147204(+) GATCTC/TGGCTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RAB21 (72148654 - 72184699 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for RAB21:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2658849CNV Deletion23128226
    nsv832451CNV Loss17160897
    dgv1447n71CNV Gain21882294
    nsv899244CNV Gain21882294
    esv35030CNV Gain17911159
    essv4115CNV CNV17122850
    dgv519e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612398    OMIM disorders: --

    3 diseases for RAB21:    
    About MalaCards
    insulin resistance    lymphoblastic leukemia    leukemia


    RAB21 for disorders           About GeneDecksing


    Export disorders for RAB21 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RAB21 gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with RAB21)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression of Rab small GTPases in epithelial Caco-2 cells: Rab21 is an apically located GTP-binding protein in polarised intestinal epithelial cells. (PubMed id 10887961)1, 2, 3 Opdam F.J.M....Fransen J.A.M. (Eur. J. Cell Biol. 2000)
    2. Integrin trafficking regulated by Rab21 is necessary for cytokinesis. (PubMed id 18804435)1, 2 Pellinen T.... Ivaska J. (Dev. Cell 2008)
    3. Structural basis for Rab GTPase activation by VPS9 domain exchange factors. (PubMed id 17450153)1, 2 Delprato A. and Lambright D.G. (Nat. Struct. Mol. Biol. 2007)
    4. Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins. (PubMed id 16754960)1, 3 Pellinen T....Ivaska J. (J. Cell Biol. 2006)
    5. Structural basis of family-wide Rab GTPase recognition by rabenosyn- 5. (PubMed id 16034420)1, 2 Eathiraj S.... Lambright D.G. (Nature 2005)
    6. A role for the small GTPase Rab21 in the early endocytic pathway. (PubMed id 15561770)1, 2 Simpson J.C.... Jones A.T. (J. Cell Sci. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Evolution of the Rab family of small GTP-binding proteins. (PubMed id 11697911)1, 3 Pereira-Leal J.B. and Seabra M.C. (J. Mol. Biol. 2001)
    9. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7788527)1, 2 Nagase T.... Nomura N. (DNA Res. 1995)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23011 HGNC: 18263 AceView: RAB21 Ensembl:ENSG00000080371 euGenes: HUgn23011
    ECgene: RAB21 H-InvDB: RAB21

    (According to HUGE)
    About This Section

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    HUGE: KIAA0118

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RAB21 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAB21 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for RAB21 gene:
    Search GeneIP for patents involving RAB21

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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