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Aliases & Descriptions for RAB21
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| KIAA0118 1, 2, 3, 5 |
| | | Descriptions |
|---|
| RAB21, member RAS oncogene family 2 |
|
| | Search outside databases for aliases for RAB21 genePrevious GC identifers: GC12P071929 GC12P072100 |
Summaries for RAB21(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for RAB21: RAB21 belongs to the RAB family of small GTP-binding proteins that regulate intracellular vesicle targeting (Opdam et al., 2000 [PubMed 10887961]).[supplied by OMIM] UniProtKB/Swiss-Prot: RAB21_HUMAN, Q9UL25Function: Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general. As a result, may regulate cell adhesion and migration (By similarity). During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesisGene Wiki entry for RAB21 |
Genomic Location for RAB21
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the RAB21 gene 
Entrez Gene cytogenetic band: 12q21.1 Ensembl cytogenetic band: 12q21.1 HGNC cytogenetic band: 12q15RAB21 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P070434:
(about GC identifiers)
Start:
|
70,434,925 bp from pter |
End:
|
70,467,417 bp from pter |
Size:
|
32,493 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000012.10 NT_029419.11
| Proteins for RAB21
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: RAB21_HUMAN, Q9UL25 (See
protein sequence)Recommended Name: Ras-related protein Rab-21 Size: 225 amino acids; 24348 Da
Subunit: Interacts with the cytoplasmic tail of integrins ITGA1, ITGA2, ITGA5, ITGA6, ITGA11 and ITGB1 (By similarity)
Subcellular location: Endoplasmic reticulum membrane; Lipid-anchor (By similarity). Golgi apparatus membrane. Early endosome membrane. Cytoplasmic vesicle membrane. Note=In nonpolarized epithelial Caco-2 cells, found in the endoplasmic reticulum; in polarized cells, observed in vesicles in the apical cytoplasm. During mitosis, in mid-telophase, localized in the ingressing cleavage furrow. In late telophase, detected at the opposite poles of the daughter cells, in vesicles at the base of lamellipodia formed by the separating daughter cells
PDB structures from and Proteopedia :1YZT (3D)
 1YZU (3D)
 1Z08 (3D)
 1Z0I (3D)
 2OT3 (3D)
 
Secondary accessions: Q14466 Q569H3REFSEQ proteins: NP_055814.1
ENSEMBL proteins: ENSP00000261263
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: RAB21 
4 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for RAB21: Assays for RAB21: | Protein
Domains/ Families for RAB21(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9UL25
ProtoNet protein and cluster: Q9UL25 1 Blocks protein family: IPB001806 Transforming protein P21 RAS signature
UniProtKB/Swiss-Prot: RAB21_HUMAN, Q9UL25Similarity: Belongs to the small GTPase superfamily. Rab family | Gene Function for RAB21
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014999
Applied Biosystems Silencer® siRNAs for RAB21
Sigma-Aldrich siRNA and siRNA Panels for RAB21  Sigma-Aldrich shRNA for RAB21  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_014999                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_014999                                  untagged cDNA clone in CMV expression vector: NM_014999 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_014999
UniProtKB/Swiss-Prot: RAB21_HUMAN, Q9UL25Function: Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general. As a result, may regulate cell adhesion and migration (By similarity). During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis2 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000166 | nucleotide binding |
IEA | -- | | GO:0005525 | GTP binding |
IEA | -- | About this table | Pathways & Interactions for RAB21
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
3 Interacting proteins for RAB21 (Q9UL252 ENSP000002612633) via UniProtKB, MINT, and/or STRINGAbout this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007264 | small GTPase mediated signal transduction |
IEA | -- | | GO:0015031 | protein transport |
IEA | -- | About this table
|
Drugs & Compounds for RAB21(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|  |
Enzo Life Sciences drugs & compounds for RAB21 |
Browse Tocris compounds for RAB21
|
Transcripts for RAB21(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014999
Sigma-Aldrich siRNA and siRNA Panels for RAB21  Sigma-Aldrich shRNA for RAB21  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_014999 REFSEQ mRNAs for RAB21 gene: NM_014999.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_014999               OriGene GFP tagged cDNA clone in CMV expression vector: NM_014999                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_014999                                  untagged cDNA clone in CMV expression vector: NM_014999  Additional cDNA sequence: AB075482.1 AF091035.1 BC009109.1 BC021901.1 BC092475.1 CR590140.1 CR600765.1 CR604873.1 D42087.1 9 DOTS entries: DT.209481 DT.91922497 DT.97861767 DT.100826817 DT.65284362 DT.100680561 DT.75102206 DT.100826811 DT.121206658 24/221 AceView cDNA sequences (see all 221
):BX119716 BM893579 BM978770 CD722746 D42087 CA314817 BG771050 BQ437436 BE501894 BP382887 CA866159 AA922618 BX117131 BQ686309 BF063415 BX499957 CK430593 CR600765 BM471710 AI025203 CR590140 AI274214 BF060662 CA941131
highest scoring ESTs for RAB21:D42087 AA581270 AF091035 AI025203 AI189956 AI219379 AI471033 AL041855 AL526366 BC009109 Unigene Cluster for RAB21: RAB21, member RAS oncogene family Hs.524590 [show with all ESTs]Unigene Representative Sequence: BC009109
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000261263
|
Expression for RAB21
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| RAB21 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for RAB21
1 / 2 / 3 3 probe-sets matching RAB21 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TAATGCAGAT
SOURCE GeneReport for Unigene cluster: Hs.524590
Expression variation in blood from EXPOLDB for RAB21 UniProtKB/Swiss-Prot: RAB21_HUMAN, Q9UL25Tissue specificity: Widely expressed. In jejunal tissue, predominantly expressed in the apical region of the epithelial cell layer of the villi, weak expression, if any, in the crypt epithelium. Capillary endothelium and some cell types in the lamina propria also show expression |
Orthologs for RAB21
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for RAB21 gene from 5/12 species (see all 12
)
About this table Species with no ortholog for RAB21
ENSEMBL Gene Tree for RAB21 | Paralogs for RAB21(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for RAB21 gene
- RAB202 RAB6C2 RAB412 RAB6A2 RAB6B2
|
SNPs/Variants for RAB21(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for RAB21 (up to first 250kb)
|
Disorders & Mutations for RAB21
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 612398
|
Medical News for RAB21(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for RAB21 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/13 PubMed articles for RAB21 gene (see all 13
):- Expression of Rab small GTPases in epithelial Caco-2 cells: Rab21 is an apically located GTP-binding protein in polarised intestinal epithelial cells. (PubMed id 10887961)2, 3, 4 Opdam F.J.M....Fransen J.A.M. (2000)
- Integrin trafficking regulated by Rab21 is necessary for cytokinesis. (PubMed id 18804435)3, 4 Pellinen T....Ivaska J. (2008)
- Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins. (PubMed id 16754960)2, 3 Pellinen T....Ivaska J. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Evolution of the Rab family of small GTP-binding proteins. (PubMed id 11697911)2, 3 Pereira-Leal J.B. and Seabra M.C. (2001)
- Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7788527)3, 4 Nagase T....Kotani H. (1995)
- The LIFEdb database in 2006. (PubMed id 16381901)3 Mehrle A....Wiemann S. (2006)
- A role for the small GTPase Rab21 in the early endocytic pathway. (PubMed id 15561770)4 Simpson J.C.... Jones A.T. (2004)
- From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)3 Wiemann S....Poustka A. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
|
Search for RAB21
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing RAB21
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing RAB21
(According to HUGE)
About This Section
| |
Specialized Databases showing RAB21(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for RAB21(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for RAB21:

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