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RAB20 Gene

protein-coding GIFtS: 46

GC13M109973

RAB20, member RAS oncogene family
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
FLJ20429 ^¹, ²
OTTHUMP00000040648 ^²

Descriptions
RAB20, member RAS oncogene family ^²

External Ids
HGNC: 18260¹
Entrez Gene: 55647²
UniProtKB: Q9NX57³
Ensembl: ENSG00000139832⁷

Search outside databases for aliases for RAB20 gene

Previous GC identifers: GC13M109535 GC13M105562 GC13M110012 GC13M108873

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: RAB20_HUMAN, Q9NX57

Function: Plays a role in apical endocytosis/recycling

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the RAB20 gene

Entrez Gene cytogenetic band: 13q34 Ensembl cytogenetic band: 13q34 HGNC cytogenetic band: 13q34

RAB20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13M109973: (about GC identifiers)

Start:	109,973,414 bp from pter
End:	110,012,081 bp from pter
Size:	38,668 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000013.9 NT_009952.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: RAB20_HUMAN, Q9NX57 (See protein sequence)

Recommended Name: Ras-related protein Rab-20

Size: 234 amino acids; 26277 Da

Subcellular location: Golgi apparatus. Note=Highly enriched on apical endocytic structures in

polarized epithelial cells of kidney proximal tubules (By similarity)

Secondary accessions: Q9NX49

REFSEQ proteins: NP_060287.1

ENSEMBL proteins:

ENSP00000267328

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Rab20)
	Human Recombinant Proteins from Abnova (RAB20)

OriGene Purified Recombinant Human Protein: RAB20

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005794	Golgi apparatus	IEA	--

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Antibodies for RAB20:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Rab20), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (RAB20)
	Novus Biologicals Antibodies for RAB20

Assays for RAB20:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9NX57

ProtoNet protein and cluster: Q9NX57

UniProtKB/Swiss-Prot: RAB20_HUMAN, Q9NX57

Similarity: Belongs to the small GTPase superfamily. Rab family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (RAB20)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_017817

Applied Biosystems Silencer® siRNAs for RAB20

Sigma-Aldrich siRNA for RAB20

Sigma-Aldrich shRNA for RAB20

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for RAB20
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_017817
Myc/DDK tagged cDNA clone in CMV expression vector: NM_017817
untagged cDNA clone in CMV expression vector: NM_017817

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_017817

UniProtKB/Swiss-Prot: RAB20_HUMAN, Q9NX57

Function: Plays a role in apical endocytosis/recycling

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0005525	GTP binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007264	small GTPase mediated signal transduction	IEA	--
GO:0015031	protein transport	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for RAB20

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for RAB20

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (RAB20)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_017817

Sigma-Aldrich siRNA for RAB20

Sigma-Aldrich shRNA for RAB20

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_017817

REFSEQ mRNAs for RAB20 gene:

NM_017817.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_017817

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_017817
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_017817
                                 untagged cDNA clone in CMV expression vector: NM_017817

Additional cDNA sequence:

AJ272065.1 AK000436.1 AK000446.1 BC026025.1

4 DOTS entries:

DT.435643 DT.437936 DT.95262492 DT.75101003

24/63 AceView cDNA sequences (see all 63 ):

AI522056 AI768579 AW007099 AW615269 BE464359 CD364429 BM727626 AI005185

AA604947 BU681309 AW139692 BM694745 BQ949262 BG437627 BQ940852 BM681061

BI837210 BE512973 BG217213 AK000446 BG489444 BX116686 AW961598 AI628077

highest scoring ESTs for RAB20:

AI862700 AA632406 AI005185 AI347353 AI628077 AI740961 AJ272065 AK000436 AK000446 AW236863

Unigene Cluster for RAB20:

RAB20, member RAS oncogene family

Hs.719403 [show with all ESTs]

Unigene Representative Sequence: BC026025

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000267328

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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RAB20 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for RAB20

¹ / ² / ³

4 probe-sets matching RAB20 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
77572_at²^{, 3}	U95-E	1	1.00	1.00	0.81	1.12	AI740961	0.80	1.00	0.91	1
83199_at²^{, 3}	U95-E	1	1.00	1.00	0.81	0.88	AI862700	1.00	1.00	1.00	1
219622_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_017817	0.60	1.00	0.82	1
219622_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks RAB20 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
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About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.719403
UniProtKB/Swiss-Prot: RAB20_HUMAN, Q9NX57
Tissue specificity: Low or absent expression in normal pancreas and stronger expression in 15 of 18
exocrine pancreatic adenocarcinomas (at protein level)

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for RAB20 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	RAB20¹	--	RAB20, member RAS oncogene family	84.76(n) 84.19(a)	485549 XM_542668.2 XP_542668.2
chimpanzee (Pan troglodytes)	RAB20¹	--	RAB20, member RAS oncogene family	98.86(n) 97.86(a)	736231 XM_001137007.1 XP_001137007.1
cow (Bos taurus)	RAB20¹	--	RAB20, member RAS oncogene family	80.81(n) 80.52(a)	615760 XM_867651.2 XP_872744.2
rat (Rattus norvegicus)	Rab20¹	--	RAB20, member RAS oncogene family	81.9(n) 80.6(a)	689377 XM_001070580.1 XP_001070580.1
mouse (Mus musculus)	Rab20^{1, 5}	8 (10.00 cM)⁵	RAB20, member RAS oncogene family^{1, 5}	81.97(n)¹ 82.83(a)¹	19332¹ NM_011227.1¹ NP_035357.1¹ AA536966⁵ AB232614⁵ (see all 17)

About this table Species with no ortholog for RAB20

ENSEMBL Gene Tree for RAB20

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for RAB20 gene

RAB21² RAB6C² RAB41² RAB6A² RAB6B²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/479 NCBI SNPs in RAB20 are shown (see all 479 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 157)

AB	SNP ID	Valid	Chr 13 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs4773208^1,2	A,C,F,H	109972958(+)	`GCACTC/TATGAA`	1	--	ng5¹		7		EU EA WA NA	544
	rs3742189^1,2	A,C,F,H	109973420(+)	`AAGTTG/TTTCCA`	1	--	ut3¹		13		EA NA EU WA	2340
	rs3742188^1,2	A,C,F,H	109973245(+)	`ACTAGG/ACAGAT`	1	--	ng5¹		19		EA NA EU WA	3120
	rs1059289^1,2	A,C,F,H	109973710(-)	`CAGCCA/TCCAAC`	1	--	ut3¹ ese³		9		MN EU EA WA	1004
	rs426453^1,2	C,F,H	109974317(+)	`CCATAT/CTGGGA`	1	S/N	mis¹ ese³		17		EA NA MN EU WA	1386
--	rs424904^1,2	A,C	110012922(+)	`tagtaA/Gacacg`	1	--	ng3¹		0	--	--	--	--
--	rs2479435^1,2	A	110013514(+)	`agaaaA/Cagata`	1	--	ng3¹		0	--	--	--	--
--	rs395289^1,2	A	110012963(+)	`gaactC/Gctgac`	1	--	ng3¹		0	--	--	--	--
--	rs9521843^1,2	A	110013851(+)	`GCTCTA/GTTTGT`	1	--	ng3¹		0	--	--	--	--
	rs3742190^1,2	F	109973719(+)	`TGGCTG/CCAAAG`	1	--	ut3¹ ese³		1		EA	1500

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HapMap Linkage Disequilibrium images for RAB20 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

7 PubMed articles for RAB20 gene:

Characterization of human Rab20 overexpressed in exocrine pancreatic carcinoma. (PubMed id 16613320)^{3, 4} Amillet J.-M.... Goubin G. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Evolution of the Rab family of small GTP-binding proteins. (PubMed id 11697911)^{2, 3} Pereira-Leal J.B. and Seabra M.C. (2001)
Identification of rab20 as a potential regulator of connexin 43 trafficking. (PubMed id 18649179)³ Das Sarma J....Koval M. (2008)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Cloning and subcellular localization of novel rab proteins reveals polarized and cell type-specific expression. (PubMed id 7706395)³ Lutcke A....Zerial M. (1994)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 55647	HGNC: 18260	AceView: RAB20	Ensembl:ENSG00000139832	euGenes: HUgn55647
ECgene: RAB20	H-InvDB: RAB20

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for RAB20	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for RAB20
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for RAB20:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for RAB20-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for RAB20		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for RAB20		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (RAB20)
	Antibodies (RAB20)
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (Rab20)
	Antibodies (Rab20)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for RAB20

	Drugs for RAB20
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for RAB20

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RAB20 Gene

protein-coding GIFtS: 46

Aliases &
Descriptions
for RAB20

Summaries
for RAB20

Genomic Location
for RAB20

Proteins
for RAB20

Protein Domains/
Families
for RAB20

Gene Function
for RAB20

Pathways & Interactions
for RAB20

Drugs & Compounds
for RAB20

Transcripts
for RAB20

Expression
for RAB20

Orthologs
for RAB20

Paralogs
for RAB20

SNPs/Variants
for RAB20

Disorders & Mutations
for RAB20

Medical News
for RAB20

Publications
for RAB20

Search for RAB20

Genome Databases showing RAB20

Other Databases showing RAB20

Specialized Databases showing RAB20

Licensable Technologies
for RAB20

Services
for RAB20

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

RAB20 Gene

protein-coding GIFtS: 46

Aliases & Descriptionsfor RAB20

Summariesfor RAB20

Genomic Locationfor RAB20

Proteinsfor RAB20

Protein Domains/Familiesfor RAB20

Gene Functionfor RAB20

Pathways & Interactionsfor RAB20

Drugs & Compoundsfor RAB20

Transcriptsfor RAB20

Expression for RAB20

Orthologsfor RAB20

Paralogsfor RAB20

SNPs/Variantsfor RAB20

Disorders & Mutationsfor RAB20

Medical Newsfor RAB20

Publicationsfor RAB20

Search for RAB20

Genome Databases showing RAB20

Other Databases showing RAB20

Specialized Databases showing RAB20

Licensable Technologiesfor RAB20

Servicesfor RAB20

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for RAB20

Summaries
for RAB20

Genomic Location
for RAB20

Proteins
for RAB20

Protein Domains/
Families
for RAB20

Gene Function
for RAB20

Pathways & Interactions
for RAB20

Drugs & Compounds
for RAB20

Transcripts
for RAB20

Expression
for RAB20

Orthologs
for RAB20

Paralogs
for RAB20

SNPs/Variants
for RAB20

Disorders & Mutations
for RAB20

Medical News
for RAB20

Publications
for RAB20

Licensable Technologies
for RAB20

Services
for RAB20