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Aliases for RAB20 Gene

Aliases for RAB20 Gene

  • RAB20, Member RAS Oncogene Family 2 3

External Ids for RAB20 Gene

Previous GeneCards Identifiers for RAB20 Gene

  • GC13M109535
  • GC13M105562
  • GC13M110012
  • GC13M108873
  • GC13M109973
  • GC13M111175
  • GC13M091774

Summaries for RAB20 Gene

GeneCards Summary for RAB20 Gene

RAB20 (RAB20, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include GTP binding. An important paralog of this gene is RAB5C.

UniProtKB/Swiss-Prot for RAB20 Gene

  • Plays a role in apical endocytosis/recycling. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB20 Gene

Genomics for RAB20 Gene

Regulatory Elements for RAB20 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RAB20 Gene

110,523,066 bp from pter
110,561,733 bp from pter
38,668 bases
Minus strand

Genomic View for RAB20 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAB20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB20 Gene

Proteins for RAB20 Gene

  • Protein details for RAB20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras-related protein Rab-20
    Protein Accession:
    Secondary Accessions:
    • Q5T9X5
    • Q9NX49

    Protein attributes for RAB20 Gene

    234 amino acids
    Molecular mass:
    26277 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RAB20 Gene

Proteomics data for RAB20 Gene at MOPED

Post-translational modifications for RAB20 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB20 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RAB20 Gene

Domains for RAB20 Gene

Gene Families for RAB20 Gene

  • RAB :RAB, member RAS oncogene

Protein Domains for RAB20 Gene

Suggested Antigen Peptide Sequences for RAB20 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9NX57
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB20: view

Function for RAB20 Gene

Molecular function for RAB20 Gene

UniProtKB/Swiss-Prot Function: Plays a role in apical endocytosis/recycling. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes.

Gene Ontology (GO) - Molecular Function for RAB20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IBA --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RAB20: view

Phenotypes for RAB20 Gene

genes like me logo Genes that share phenotypes with RAB20: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RAB20 Gene

Localization for RAB20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB20 Gene

Golgi apparatus. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Note=Highly enriched on apical endocytic structures in polarized epithelial cells of kidney proximal tubules (By similarity). Recruited to phagosomes containing S.aureus or M.tuberculosis. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for RAB20 Gene COMPARTMENTS Subcellular localization image for RAB20 gene
Compartment Confidence
golgi apparatus 5
cytosol 3
nucleus 2
endosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RAB20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005769 early endosome IBA --
GO:0005794 Golgi apparatus IDA --
GO:0005886 NOT plasma membrane IBA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with RAB20: view

Pathways for RAB20 Gene

genes like me logo Genes that share pathways with RAB20: view

Pathways by source for RAB20 Gene

1 Qiagen pathway for RAB20 Gene

Gene Ontology (GO) - Biological Process for RAB20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport IBA --
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction --
GO:0008152 metabolic process IBA --
genes like me logo Genes that share ontologies with RAB20: view

Transcripts for RAB20 Gene

mRNA/cDNA for RAB20 Gene

(1) REFSEQ mRNAs :
(63) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RAB20 Gene

RAB20, member RAS oncogene family:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAB20

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB20 Gene

No ASD Table

Relevant External Links for RAB20 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RAB20 Gene

mRNA expression in normal human tissues for RAB20 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB20 Gene

This gene is overexpressed in Whole Blood (7.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB20 Gene

SOURCE GeneReport for Unigene cluster for RAB20 Gene Hs.743563

mRNA Expression by UniProt/SwissProt for RAB20 Gene

Tissue specificity: Low or absent expression in normal pancreas and stronger expression in 15 of 18 exocrine pancreatic adenocarcinomas (at protein level).
genes like me logo Genes that share expressions with RAB20: view

In Situ Assay Products

Orthologs for RAB20 Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB20 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RAB20 35
  • 98.86 (n)
  • 97.86 (a)
RAB20 36
  • 98 (a)
(Bos Taurus)
Mammalia RAB20 35
  • 80.52 (n)
  • 80.09 (a)
RAB20 36
  • 81 (a)
(Canis familiaris)
Mammalia RAB20 35
  • 83.9 (n)
  • 83.76 (a)
RAB20 36
  • 84 (a)
(Mus musculus)
Mammalia Rab20 35
  • 81.97 (n)
  • 82.83 (a)
Rab20 16
Rab20 36
  • 83 (a)
(Monodelphis domestica)
Mammalia RAB20 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia RAB20 36
  • 65 (a)
(Rattus norvegicus)
Mammalia Rab20 35
  • 81.9 (n)
  • 80.6 (a)
(Gallus gallus)
Aves RAB20 35
  • 76.81 (n)
  • 75.65 (a)
RAB20 36
  • 75 (a)
(Anolis carolinensis)
Reptilia RAB20 36
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rab20 35
  • 67.42 (n)
  • 71.04 (a)
(Danio rerio)
Actinopterygii rab20 35
  • 64.7 (n)
  • 65.91 (a)
rab20 36
  • 63 (a)
wufb01f02 35
fruit fly
(Drosophila melanogaster)
Insecta chrw 36
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
Species with no ortholog for RAB20:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAB20 Gene

Gene Tree for RAB20 (if available)
Gene Tree for RAB20 (if available)

Paralogs for RAB20 Gene

Selected SIMAP similar genes for RAB20 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RAB20: view

Variants for RAB20 Gene

Sequence variations from dbSNP and Humsavar for RAB20 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs331593 -- 110,551,379(+) AGAAC(A/C)GAGCA intron-variant
rs331594 -- 110,552,236(+) tagcc(A/G)ggcat intron-variant
rs331595 -- 110,553,029(+) GACAA(C/T)CAATT intron-variant
rs331596 -- 110,553,720(+) ACTAA(C/T)TGTCA intron-variant
rs331597 -- 110,553,776(+) TCTCC(C/T)GACTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB20 Gene

Variant ID Type Subtype PubMed ID
nsv509516 CNV Insertion 20534489
nsv832720 CNV Loss 17160897
nsv901009 CNV Loss 21882294
dgv1791n71 CNV Gain 21882294
esv1619657 CNV Deletion 17803354

Relevant External Links for RAB20 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB20 Gene

Disorders for RAB20 Gene

Relevant External Links for RAB20

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with RAB20: view

No data available for UniProtKB/Swiss-Prot for RAB20 Gene

Publications for RAB20 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Characterization of human Rab20 overexpressed in exocrine pancreatic carcinoma. (PMID: 16613320) Amillet J.-M. … Goubin G. (Hum. Pathol. 2006) 3 4
  4. Evolution of the Rab family of small GTP-binding proteins. (PMID: 11697911) Pereira-Leal J.B. … Seabra M.C. (J. Mol. Biol. 2001) 2 3
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for RAB20 Gene

Sources for RAB20 Gene

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