RAB20 Gene
protein-coding GIFtS : 46
GCID: GC13 M111175
RAB20, member RAS oncogene family
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Aliasesfor RAB20 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases RAB20, Member RAS Oncogene Family 1 2 FLJ204291 Ras-Related Protein Rab-202
Export aliases for RAB20 gene to outside databases Previous GC identifers: GC13M109535 GC13M105562 GC13M110012 GC13M108873 GC13M109973 GC13M091774
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Summariesfor RAB20 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: RAB20_HUMAN, Q9NX57 Function : Plays a role in apical endocytosis/recycling. Plays a role in the maturation and acidification of phagosomesthat engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes
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Genomic Viewsfor RAB20 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000013.10 NC_018924.1 NT_009952.14 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the RAB20 gene promoter: HOXA3 MEF-2 HSF1 (long) Roaz C/EBPalpha c-Ets-1 MEF-2A CP2 STAT3 HSF1short Other transcription factors Search SABiosciences Chromatin IP Primers for RAB20 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat RAB20
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 13q34 Ensembl cytogenetic band: 13q34 HGNC cytogenetic band: 13q34 RAB20 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 13 GeneLoc Exon Structure
GeneLoc location for GC13M111175: view genomic region
(about GC identifiers )
Start:
111,175,413 bp from pter
End:
111,214,080 bp from pter
Size:
38,668 bases
Orientation:
minus strand
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Proteinsfor RAB20 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: RAB20_HUMAN, Q9NX57 (See
protein sequence )Recommended Name: Ras-related protein Rab-20 Size : 234 amino acids; 26277 Da
Subcellular location : Golgi apparatus. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane;Lipid-anchor; Cytoplasmic side (By similarity). Note=Highly enriched on apical endocytic structures in polarized epithelial cells of kidney proximal tubules (By similarity). Recruited to phagosomes containing S.aureus or M.tuberculosis
Secondary accessions : Q5T9X5 Q9NX49Explore the universe of human proteins at neXtProt for RAB20: NX_Q9NX57 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9NX57 RAB20 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_060287.1 ENSEMBL proteins: ENSP00000267328 Human Recombinant Protein Products: Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view) : About this table
RAB20 for ontologies About GeneDecksing RAB20 Antibody Products: Assay Products for RAB20:
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Protein
Domains / Familiesfor RAB20 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
RAB20 for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q9NX57 ProtoNet protein and cluster: Q9NX57
UniProtKB/Swiss-Prot: RAB20_HUMAN, Q9NX57 Similarity : Belongs to the small GTPase superfamily. Rab family
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Functionfor RAB20 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: RAB20_HUMAN, Q9NX57 Function : Plays a role in apical endocytosis/recycling. Plays a role in the maturation and acidification of phagosomesthat engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for RAB20 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for RAB20OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: RAB20 (NM_017817 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RAB20 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RAB20
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB20
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005525 GTP binding
IEA --
RAB20 for ontologies About GeneDecksing 2 GenomeRNAi human phenotypes for RAB20 :
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Pathways & Interactionsfor RAB20 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways   About this table See pathways by source Super-pathway contained gene-specific pathways 1 Sertoli-Sertoli Cell Junction Dynamics
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RAB20 Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RAB20 STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)3 Interacting proteins for RAB20 (ENSP00000267328 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 4 biological process terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0007264 small GTPase mediated signal transduction
IEA -- GO:0015031 protein transport
IEA -- GO:0090383 phagosome acidification
IMP -- GO:0090385 phagosome-lysosome fusion
IMP --
RAB20 for ontologies About GeneDecksing
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Drugs & Compoundsfor RAB20 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for RAB20 Search CenterWatch for drugs/clinical trials and news about RAB20
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Transcriptsfor RAB20 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for RAB20 gene: NM_017817.1 Unigene Cluster for RAB20:
RAB20, member RAS oncogene family Hs.743563 [show with all ESTs ] Unigene Representative Sequence: BC026025 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000267328 (uc001vqy.3 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for RAB20 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for RAB20OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: RAB20 (NM_017817 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RAB20 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RAB20
Additional cDNA sequence: AJ272065.1 AK000436.1 AK000446.1 BC026025.1
4 DOTS entries : DT.435643 DT.437936
DT.95262492 DT.75101003 24/63 AceView cDNA sequences (see all 63 ):
AI005185 AI768579 AI522056 BE464359 AW615269 AA604947 CD364429 BM727626 AW007099 BU681309 BV206000 BG489444 BI837210 BQ940852 AI347353 AJ272065 AW117221 AW139692 BG330807 AI628077 BQ949262 CD520161 CB154459 NM_017817 GeneLoc Exon Structure
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Expression for RAB20 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section RAB20 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TATTATTAAA
About this image RAB20 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 2 LifeMap Cells Name Category Definitive endoderm-like cells (A scalable, suspensi... )Epiblast-like cells (Reconstitution of mo... )Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See RAB20 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for RAB20 SOURCE GeneReport for Unigene cluster: Hs.743563 UniProtKB/Swiss-Prot: RAB20_HUMAN, Q9NX57 Tissue specificity : Low or absent expression in normal pancreas and stronger expression in 15 of 18 exocrine pancreaticadenocarcinomas (at protein level) SABiosciences Custom PCR Arrays for RAB20 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for RAB20Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat RAB20 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat RAB20 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat RAB20 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB20
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Orthologsfor RAB20 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for RAB20 gene from 3/15 species (see all 15 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
RAB201
RAB20, member RAS oncogene family
76.81(n) 75.65(a)
 
418753 XM_416953.3 XP_416953.2
lizard (Anolis carolinensis)
Reptilia
RAB206
--
68(a)
1 ↔ 1
1(137422853-137431281)
zebrafish (Danio rerio)
Actinopterygii
wufb01f022
Danio rerio cDNA clone MGC64047 IMAGE6793648, complete more
75.97(n)
 
BC053222.1
ENSEMBL Gene Tree for RAB20 (if available)TreeFam Gene Tree for RAB20 (if available)
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Paralogsfor RAB20 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for RAB20 gene RAB5C 2 RAB31 2 ENSG00000267261 2 RAB5B 2 RAB21 2 RAB5A 2 RAB24 2 RAB22A 2 RAB17 2 3 SIMAP similar genes for RAB20 using alignment to 2 protein entries: RAB20_HUMAN (see all proteins ):RAB30 RAB17 RAB21
RAB20 for paralogs About GeneDecksing
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Genomic Variantsfor RAB20 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 13 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for RAB20 (111175413 - 111214080 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for RAB20: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing RAB20
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Disorders
/ Diseasesfor RAB20 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
RAB20 for disorders About GeneDecksing 5 diseases for RAB20 : About MalaCards hemophagocytic lymphohistiocytosis pancreatic carcinoma pancreatitis adenocarcinoma carcinoma Human Genome Epidemiology (HuGE) Navigator: RAB20 (1 document)Export disorders for RAB20 gene to outside databases
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Publicationsfor RAB20 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for RAB20 gene, integrated from 9 sources (see all 11 ): (articles sorted by number of sources associating them with RAB20) Utopia : connect your pdf to the dynamic world of online information
Characterization of human Rab20 overexpressed in exocrine pancreatic carcinoma. (PubMed id 16613320) 1 , 2 Amillet J.-M.... Goubin G. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Evolution of the Rab family of small GTP-binding proteins. (PubMed id 11697911) 1 , 3 Pereira-Leal J.B. and Seabra M.C. (2001) Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes. (PubMed id 21255211) 2 Seto S.... Koide Y. (2011) Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048) 1 Danielsen J.M....Nielsen M.L. (2011) Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614) 1 Rose J.E....Uhl G.R. (2010) Identification of rab20 as a potential regulator of connexin 43 trafficking. (PubMed id 18649179) 1 Das Sarma J....Koval M. (2008) The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823) 2 Dunham A.... Ross M.T. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for RAB20 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing RAB20 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing RAB20 gene
(According to HUGE )
About This Section --
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Specialized Databases showing RAB20 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for RAB20 gene: Search GeneIP for patents involving RAB20 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor RAB20 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for RAB20 OriGene shRNA RFP for RAB20 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for RAB20 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for RAB20 OriGene Protein Over-expression Lysate for RAB20 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for RAB20 OriGene 3'-UTR Clone for RAB20 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for RAB20 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for RAB20 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for RAB20 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for RAB20 OriGene Custom Protein Services for RAB20 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RAB20 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing RAB20 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat RAB20 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat RAB20 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat RAB20 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat RAB20
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RAB20 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB20
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RAB20
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Aliases for RAB20
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Disorders / Diseases for RAB20
Domains / Families for RAB20
Drugs / Compounds for RAB20
Expression for RAB20
Function for RAB20
Genomic Views for RAB20
Intellectual Property for RAB20
Orthologs for RAB20
Paralogs for RAB20
Pathways / Interactions for RAB20
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Summaries for RAB20
Transcripts for RAB20
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