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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RAB20 Gene

protein-coding   GIFtS: 46
GCID: GC13M111175

RAB20, member RAS oncogene family

 Explore 5 diseases affiliated with
RAB20 via our new
 Human Malady Compendium 
Biological research products
for RAB20
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
RAB20, Member RAS Oncogene Family1 2
FLJ204291
Ras-Related Protein Rab-202

External Ids:    HGNC: 182601   Entrez Gene: 556472   Ensembl: ENSG000001398327   UniProtKB: Q9NX573   

Export aliases for RAB20 gene to outside databases

Previous GC identifers: GC13M109535 GC13M105562 GC13M110012 GC13M108873 GC13M109973 GC13M091774


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: RAB20_HUMAN, Q9NX57
Function: Plays a role in apical endocytosis/recycling. Plays a role in the maturation and acidification of phagosomes
that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.1  NT_009952.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RAB20 gene promoter:
         HOXA3   MEF-2   HSF1 (long)   Roaz   C/EBPalpha   c-Ets-1   MEF-2A   CP2   STAT3   HSF1short   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRAB20 promoter sequence
   Search SABiosciences Chromatin IP Primers for RAB20

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB20


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q34   Ensembl cytogenetic band:  13q34   HGNC cytogenetic band: 13q34

RAB20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAB20 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M111175:  view genomic region     (about GC identifiers)

Start:
111,175,413 bp from pter      End:
111,214,080 bp from pter
Size:
38,668 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RAB20_HUMAN, Q9NX57 (See protein sequence)
Recommended Name: Ras-related protein Rab-20  
Size: 234 amino acids; 26277 Da
Subcellular location: Golgi apparatus. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane;
Lipid-anchor; Cytoplasmic side (By similarity). Note=Highly enriched on apical endocytic structures in polarized
epithelial cells of kidney proximal tubules (By similarity). Recruited to phagosomes containing S.aureus or
M.tuberculosis
Secondary accessions: Q5T9X5 Q9NX49

Explore the universe of human proteins at neXtProt for RAB20: NX_Q9NX57

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NX57

  • RAB20 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_060287.1  
    ENSEMBL proteins: 
     ENSP00000267328  

    Human Recombinant Protein Products: 
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    Uscn Proteins for RAB20

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005794Golgi apparatus IEA--
    GO:0030670phagocytic vesicle membrane IEA--
    GO:0045335phagocytic vesicle IDA--


    RAB20 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for RAB20


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    RAB20 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase

    Graphical View of Domain Structure for InterPro Entry Q9NX57

    ProtoNet protein and cluster: Q9NX57

    UniProtKB/Swiss-Prot: RAB20_HUMAN, Q9NX57
    Similarity: Belongs to the small GTPase superfamily. Rab family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: RAB20_HUMAN, Q9NX57
    Function: Plays a role in apical endocytosis/recycling. Plays a role in the maturation and acidification of phagosomes
    that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes

    miRNA
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    hsa-miR-3163 hsa-miR-27a hsa-miR-29a* hsa-miR-128 hsa-miR-378* hsa-miR-3681* hsa-miR-27b
    SwitchGear 3'UTR luciferase reporter plasmidRAB20 3' UTR sequence
    Inhib. RNA
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    Clone
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB20

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005525GTP binding IEA--


    RAB20 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for RAB20:
     Decreased cilium length after   Increased circadian period len 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions0.36

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RAB20
        Epithelial Tight Junctions


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RAB20

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for RAB20 (ENSP000002673284) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMURF1ENSP000003546214STRING: ENSP00000354621
    SMAD4ENSP000003415514STRING: ENSP00000341551
    TGFBR1ENSP000003641334STRING: ENSP00000364133
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0015031protein transport IEA--
    GO:0090383phagosome acidification IMP--
    GO:0090385phagosome-lysosome fusion IMP--


    RAB20 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RAB20
    Search CenterWatch for drugs/clinical trials and news about RAB20 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RAB20 gene: 
    NM_017817.1  

    Unigene Cluster for RAB20:

    RAB20, member RAS oncogene family
    Hs.743563  [show with all ESTs]
    Unigene Representative Sequence: BC026025
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000267328(uc001vqy.3)

    miRNA
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    hsa-miR-3163 hsa-miR-27a hsa-miR-29a* hsa-miR-128 hsa-miR-378* hsa-miR-3681* hsa-miR-27b
    SwitchGear 3'UTR luciferase reporter plasmidRAB20 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAB20
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAB20

    Additional cDNA sequence: 

    AJ272065.1 AK000436.1 AK000446.1 BC026025.1 

    4 DOTS entries:

    DT.435643  DT.437936  DT.95262492  DT.75101003 

    24/63 AceView cDNA sequences (see all 63):

    AI005185 AI768579 AI522056 BE464359 AW615269 AA604947 CD364429 BM727626 
    AW007099 BU681309 BV206000 BG489444 BI837210 BQ940852 AI347353 AJ272065 
    AW117221 AW139692 BG330807 AI628077 BQ949262 CD520161 CB154459 NM_017817 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RAB20 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TATTATTAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    RAB20 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Definitive endoderm-like cells (A scalable, suspensi...)
    Epiblast-like cells (Reconstitution of mo...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See RAB20 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RAB20

    SOURCE GeneReport for Unigene cluster: Hs.743563

    UniProtKB/Swiss-Prot: RAB20_HUMAN, Q9NX57
    Tissue specificity: Low or absent expression in normal pancreas and stronger expression in 15 of 18 exocrine pancreatic
    adenocarcinomas (at protein level)

        SABiosciences Custom PCR Arrays for RAB20
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB20

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for RAB20 gene from 3/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves RAB201 RAB20, member RAS oncogene family 76.81(n)
    75.65(a)
      418753  XM_416953.3  XP_416953.2 
    lizard
    (Anolis carolinensis)
    Reptilia RAB206
    --
    68(a)
    1 ↔ 1
    1(137422853-137431281)
    zebrafish
    (Danio rerio)
    Actinopterygii wufb01f022 Danio rerio cDNA clone MGC64047 IMAGE6793648, complete more 75.97(n)    BC053222.1 


    ENSEMBL Gene Tree for RAB20 (if available)
    TreeFam Gene Tree for RAB20 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RAB20 gene
    RAB5C2  RAB312  ENSG000002672612  RAB5B2  RAB212  RAB5A2  RAB242  RAB22A2  
    RAB172  
    3 SIMAP similar genes for RAB20 using alignment to 2 protein entries:     RAB20_HUMAN (see all proteins):
    RAB30    RAB17    RAB21

    RAB20 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/970 NCBI SNPs in RAB20 are shown (see all 970    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs582675091,2
    C,F--111174937(+) AAAAAG/-AAAGA 1 -- int12Minor allele frequency- -:0.50NA CSA 4
    rs789022761,2
    C--111174937(+) AAAAAG/AAAAGA 1 -- int11Minor allele frequency- A:0.00NA 2
    rs47732081,2
    C,F,A,H,--111174957(+) GCACTC/TATGAA 1 -- int114Minor allele frequency- T:0.49NS EA NA WA 910
    rs454519931,2
    F,--111175192(+) AACCAG/AAGCTT 1 -- int11Minor allele frequency- A:0.06NA 120
    rs1395970311,2
    --111175216(+) TATTAC/TTGGAA 1 -- int10--------
    rs37421881,2
    C,F,A,H,--111175244(+) ACTAGG/ACAGAT 1 -- int135Minor allele frequency- A:0.45EA NA NS WA CSA 4634
    rs1444344651,2
    --111175384(+) GGGGTA/GCAAAT 1 -- int10--------
    rs1163470511,2
    --111175414(+) TACCTA/CAGTTG 1 -- ut311Minor allele frequency- C:0.01WA 118
    rs37421891,2
    C,F,A,H,--111175419(+) AAGTTG/TTTCCA 1 -- ut3130Minor allele frequency- T:0.14EA NA NS WA CSA 4270
    rs1162080371,2
    C,F,--111175511(+) AACACG/ATCGAG 1 -- ut311Minor allele frequency- A:0.02WA 118

    HapMap Linkage Disequilibrium report for RAB20 (111175413 - 111214080 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for RAB20: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAB20
    DNA2.0 Custom Variant and Variant Library Synthesis for RAB20

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    RAB20 for disorders           About GeneDecksing

    5 diseases for RAB20:    About MalaCards
    hemophagocytic lymphohistiocytosis    pancreatic carcinoma    pancreatitis    adenocarcinoma
    carcinoma

    Human Genome Epidemiology (HuGE) Navigator: RAB20 (1 document)

    Export disorders for RAB20 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RAB20 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with RAB20)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of human Rab20 overexpressed in exocrine pancreatic carcinoma. (PubMed id 16613320)1, 2 Amillet J.-M.... Goubin G. (2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Evolution of the Rab family of small GTP-binding proteins. (PubMed id 11697911)1, 3 Pereira-Leal J.B. and Seabra M.C. (2001)
    5. Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes. (PubMed id 21255211)2 Seto S.... Koide Y. (2011)
    6. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    8. Identification of rab20 as a potential regulator of connexin 43 trafficking. (PubMed id 18649179)1 Das Sarma J....Koval M. (2008)
    9. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)2 Dunham A.... Ross M.T. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55647 HGNC: 18260 AceView: RAB20 Ensembl:ENSG00000139832 euGenes: HUgn55647
    ECgene: RAB20 H-InvDB: RAB20

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RAB20 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAB20 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RAB20 gene:
    Search GeneIP for patents involving RAB20

    GeneCards and IP:
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