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Aliases & Descriptions for RAB1B
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| | | Descriptions |
|---|
| RAB1B, member RAS oncogene family 2 | | small GTP-binding protein 2 |
|
| | Search outside databases for aliases for RAB1B genePrevious GC identifers: GC11P068570 GC11P067717 GC11P066285 GC11P065811 GC11P065792 |
Summaries for RAB1B(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for RAB1B: Members of the RAB protein family, such as RAB1B, are low molecular mass monomeric GTPases localized on the cytoplasmic surfaces of distinct membrane-bound organelles. RAB1B functions in the early secretory pathway and is essential for vesicle transport between the endoplasmic reticulum (ER) and Golgi (Chen et al., 1997 [PubMed 9030196]; Alvarez et al., 2003 [PubMed 12802079]).[supplied by OMIM] UniProtKB/Swiss-Prot: RAB1B_HUMAN, Q9H0U4Function: Protein transport. Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartmentsGene Wiki entry for RAB1B |
Genomic Location for RAB1B
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the RAB1B gene 
Entrez Gene cytogenetic band: 11q12 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q13.1RAB1B Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P065777:
(about GC identifiers)
Start:
|
65,777,735 bp from pter |
End:
|
65,801,539 bp from pter |
Size:
|
23,805 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000011.8 NT_033903.7
| Proteins for RAB1B
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: RAB1B_HUMAN, Q9H0U4 (See
protein sequence)Recommended Name: Ras-related protein Rab-1B Size: 201 amino acids; 22171 Da
Subunit: Interacts with MICAL1, MICAL2 and MICAL3. Interacts with GDI1; the interaction requires the GDP-bound state. Interacts with CHM/REP1; the interaction requires the GDP-bound form and is necessary for prenylation by GGTase II
Subcellular location: Membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm. Note=Targeted by REP1 to membranes of specific subcellular compartments including endoplasmic reticulum, Golgi apparatus, and intermediate vesicles between these two compartments. In the GDP-form, colocalizes with GDI in the cytoplasm (By similarity)
Miscellaneous: Rab-1B binds GTP and GDP and possesses intrinsic GTPase activity (By similarity)Post-translational modifications:
Prenylated; by GGTase II, only after interaction of the substrate with Rab escort protein 1 (REP1)1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_112243.1
ENSEMBL proteins: ENSP00000313814 ENSP00000310226 ENSP00000377642
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for RAB1B: Assays for RAB1B: | Protein
Domains/ Families for RAB1B(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9H0U4
ProtoNet protein and cluster: Q9H0U4 1 Blocks protein family: IPB001806 Transforming protein P21 RAS signature
UniProtKB/Swiss-Prot: RAB1B_HUMAN, Q9H0U4Similarity: Belongs to the small GTPase superfamily. Rab family | Gene Function for RAB1B
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_030981
Applied Biosystems Silencer® siRNAs for RAB1B
Sigma-Aldrich siRNA for RAB1B  Sigma-Aldrich shRNA for RAB1B  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_030981                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_030981                                  untagged cDNA clone in CMV expression vector: NM_030981 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_030981
UniProtKB/Swiss-Prot: RAB1B_HUMAN, Q9H0U4Function: Protein transport. Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments1 MGI phenotypic allele for Rab1b (no phenotypes)
3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for RAB1B
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for RAB1B 
5/7 Interacting proteins for RAB1B (Q9H0U41, 2 ENSP000003102263) via UniProtKB, MINT, and/or STRING (see all 7
)About this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007264 | small GTPase mediated signal transduction |
IEA | -- | | GO:0015031 | protein transport |
IEA | -- | About this table
|
Drugs & Compounds for RAB1B(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|  |
Enzo Life Sciences drugs & compounds for RAB1B |
Browse Tocris compounds for RAB1B 2 Novoseek chemical compound relationships for RAB1B gene
About this table
|
Transcripts for RAB1B(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_030981
Sigma-Aldrich siRNA for RAB1B  Sigma-Aldrich shRNA for RAB1B  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_030981 REFSEQ mRNAs for RAB1B gene: NM_030981.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_030981               OriGene GFP tagged cDNA clone in CMV expression vector: NM_030981                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_030981                                  untagged cDNA clone in CMV expression vector: NM_030981  Additional cDNA sequence: AJ245875.1 AK125412.1 AK292086.1 AK315333.1 AL136635.1 BC028331.1 BC071169.1 CR533462.1 CR591273.1 CR592347.1 CR594164.1 CR595400.1 CR598883.1 CR599415.1 CR602885.1 CR605155.1 CR612971.1 CR620997.1 CR624810.1 CR625419.1 U66621.1 24/30 DOTS entries (see all 30
): DT.100786824 DT.91908062 DT.100757341 DT.121192845 DT.99998569 DT.120735097 DT.120735063 DT.216580 DT.92041333 DT.99985353 DT.91652303 DT.100786834 DT.91867251 DT.40256768 DT.92450775 DT.95177030 DT.97864437 DT.100770591 DT.100786826 DT.100786831 DT.120735110 DT.91695929 DT.91933592 DT.92450787 24/705 AceView cDNA sequences (see all 705
):AW733009 BM922803 BP372300 BM701329 BM811149 AL558136 CR625790 BM785457 BI771821 AL552559 CA415649 BM703149 BU162772 BQ722819 BI821119 BM703546 CA393447 BE882786 AI350693 AL136864 BM466138 AA368694 CR592347 BQ718215
highest scoring ESTs for RAB1B:AA076613 AA284973 AA293334 AA327651 AA350769 AA350770 AA365610 AA401715 AA424721 AA434038 Unigene Cluster for RAB1B: RAB1B, member RAS oncogene family Hs.300816 [show with all ESTs]Unigene Representative Sequence: AK125412
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for RAB1B
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | - |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for RAB1B
3 Ensembl transcripts including schematic representations: ENST00000314965
ENST00000311481
ENST00000394080
|
Expression for RAB1B
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| RAB1B expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for RAB1B
1 / 2 / 3 5 probe-sets matching RAB1B gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TCAGGCATTT
SOURCE GeneReport for Unigene cluster: Hs.300816
|
Orthologs for RAB1B
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for RAB1B gene from 5/16 species (see all 16
)
About this table Species with no ortholog for RAB1B
ENSEMBL Gene Tree for RAB1B | Paralogs for RAB1B(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for RAB1B gene
- RAB1A2 RAB132
|
SNPs/Variants for RAB1B(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for RAB1B (up to first 250kb)
|
Disorders & Mutations for RAB1B
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 612565
|
Medical News for RAB1B(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for RAB1B (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/28 PubMed articles for RAB1B gene (see all 28
):- The putative "switch 2" domain of the Ras-related GTPase, Rab1B, plays an essential role in the interaction with Rab escort protein. (PubMed id 9437002)1, 3, 4 Overmeyer J.H....Maltese W.A. (1998)
- Prenylation of a Rab1B mutant with altered GTPase activity is impaired in cell-free systems but not in intact mammalian cells. (PubMed id 8836150)1, 3, 4 Wilson A.L.... Maltese W.A. (1996)
- The MICAL proteins and rab1: a possible link to the cytoskeleton? (PubMed id 15694364)3, 4 Fischer J.... Barnekow A. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)3, 4 Wiemann S.... Poustka A. (2001)
- RAB GTPases expressed in human melanoma cells. (PubMed id 9030196)2, 3 Chen D.... Gahl W.A. (1997)
- A bifunctional bacterial protein links GDI displacement to Rab1 activation. (PubMed id 17947549)3 Machner M.P. and Isberg R.R. (2007)
- Rab1b interacts with GBF1 and modulates both ARF1 dynamics and COPI association. (PubMed id 17429068)3 Monetta P....Alvarez C. (2007)
- Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PubMed id 17474147)3 Wu C....Li S.S. (2007)
- Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)3 Ewing R.M....Figeys D. (2007)
|
Search for RAB1B
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing RAB1B
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing RAB1B
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RAB1B(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for RAB1B(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for RAB1B:

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Incremental update: 13 Oct 2009
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