Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RAB1B Gene

protein-coding   GIFtS: 64
GCID: GC11P066036

RAB1B, Member RAS Oncogene Family

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
RAB1B, Member RAS Oncogene Family1 2
Ras-Related Protein Rab-1B2
Small GTP-Binding Protein2

External Ids:    HGNC: 183701   Entrez Gene: 818762   Ensembl: ENSG000001749037   OMIM: 6125655   UniProtKB: Q9H0U43   

Export aliases for RAB1B gene to outside databases

Previous GC identifers: GC11P068570 GC11P067717 GC11P066285 GC11P065811 GC11P065792 GC11P065777 GC11P062361


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RAB1B Gene:
Members of the RAB protein family, such as RAB1B, are low molecular mass monomeric GTPases localized on the
cytoplasmic surfaces of distinct membrane-bound organelles. RAB1B functions in the early secretory pathway and is
essential for vesicle transport between the endoplasmic reticulum (ER) and Golgi (Chen et al., 1997 (PubMed
9030196); Alvarez et al., 2003 (PubMed 12802079)).(supplied by OMIM, Jan 2009)

GeneCards Summary for RAB1B Gene: 
RAB1B (RAB1B, member RAS oncogene family) is a protein-coding gene. Diseases associated with RAB1B include legionnaires' disease, and platelet storage pool deficiency, and among its related super-pathways are Mitotic M-M/G1 phases and Cell Cycle, Mitotic. GO annotations related to this gene include GTP binding. An important paralog of this gene is RAB10.

UniProtKB/Swiss-Prot: RAB1B_HUMAN, Q9H0U4
Function: Protein transport. Regulates vesicular transport between the endoplasmic reticulum and successive Golgi
compartments

Gene Wiki entry for RAB1B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_167190.1  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RAB1B gene promoter:
         E2F-4   E2F-3a   E2F-5   MAZR   E2F-2   LCR-F1   c-Ets-1   AREB6   E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRAB1B promoter sequence
   Search SABiosciences Chromatin IP Primers for RAB1B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12   Ensembl cytogenetic band:  11q13.2   HGNC cytogenetic band: 11q13.1

RAB1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAB1B gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P066036:  view genomic region     (about GC identifiers)

Start:
66,036,004 bp from pter      End:
66,044,963 bp from pter
Size:
8,960 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RAB1B_HUMAN, Q9H0U4 (See protein sequence)
Recommended Name: Ras-related protein Rab-1B  
Size: 201 amino acids; 22171 Da
Subunit: Interacts with MICAL1, MICAL2 and MICAL3. Interacts with GDI1; the interaction requires the GDP-bound
state. Interacts with CHM/REP1; the interaction requires the GDP-bound form and is necessary for prenylation by
GGTase II
Subcellular location: Membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm. Note=Targeted by REP1 to membranes of
specific subcellular compartments including endoplasmic reticulum, Golgi apparatus, and intermediate vesicles
between these two compartments. In the GDP-form, colocalizes with GDI in the cytoplasm (By similarity)
Miscellaneous: Rab-1B binds GTP and GDP and possesses intrinsic GTPase activity (By similarity)
4 PDB 3D structures from and Proteopedia for RAB1B:
3JZA (3D)        3NKV (3D)        4HLQ (3D)        4I1O (3D)    
Secondary accessions: A8K7S1

Explore the universe of human proteins at neXtProt for RAB1B: NX_Q9H0U4

Explore proteomics data for RAB1B at MOPED 

Post-translational modifications:

  • UniProtKB: Prenylated; by GGTase II, only after interaction of the substrate with Rab escort protein 1 (REP1)
  • UniProtKB: AMPylation at Tyr-77 by L.pneumophila DrrA occurs in the switch 2 region and leads to moderate inactivation of the
    GTPase activity. It appears to prolong the lifetime of the GTP state of RAB1B by restricting access of GTPase
    effectors to switch 2 and blocking effector-stimulated GTP hydrolysis, thereby rendering RAB1B constitutively
    active. It is later de-AMPylated by L.pneumophila SidD, releasing RAB1B from bacterial phagosomes
  • UniProtKB: Phosphocholinated at Ser-76 by L.pneumophila AnkX, leading to displace GDP dissociation inhibitors (GDI). Both
    GDP-bound and GTP-bound forms can be phosphocholinated. Dephosphocholinated by L.pneumophila Lem3, restoring
    accessibility to L.pneumophila GTPase effector LepB
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H0U4

  • RAB1B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RAB1B Protein Expression
    REFSEQ proteins: NP_112243.1  
    ENSEMBL proteins: 
     ENSP00000310226   ENSP00000435195  
    Reactome Protein details: Q9H0U4
    Human Recombinant Protein Products for RAB1B: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for RAB1B
    OriGene Protein Over-expression Lysate for RAB1B
    OriGene MassSpec for RAB1B 
    OriGene Custom Protein Services for RAB1B
    GenScript Custom Purified and Recombinant Proteins Services for RAB1B
    Novus Biologicals RAB1B Proteins
    Novus Biologicals RAB1B Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for RAB1B
    Cloud-Clone Corp. Proteins for RAB1B 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion IEA--
    GO:0005794Golgi apparatus IDA--

    RAB1B for ontologies           About GeneDecksing



    RAB1B Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for RAB1B
    GenScript Custom Superior Antibodies Services for RAB1B
    Novus Biologicals RAB1B Antibodies
    Abcam antibodies for RAB1B
    Cloud-Clone Corp. Antibodies for RAB1B 
    Search ThermoFisher Antibodies for RAB1B
    LSBio Antibodies in human, mouse, rat for RAB1B 

    Assay Products for RAB1B: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RAB1B
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RAB1B
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RAB1B 
    Cloud-Clone Corp. CLIAs for RAB1B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RAB: RAB, member RAS oncogene

    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR003579 Small_GTPase_Rab_type
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q9H0U4

    ProtoNet protein and cluster: Q9H0U4

    1 Blocks protein domain: IPB001806 Transforming protein P21 RAS signature

    UniProtKB/Swiss-Prot: RAB1B_HUMAN, Q9H0U4
    Similarity: Belongs to the small GTPase superfamily. Rab family


    RAB1B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RAB1B_HUMAN, Q9H0U4
    Function: Protein transport. Regulates vesicular transport between the endoplasmic reticulum and successive Golgi
    compartments

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity ----
    GO:0005515protein binding IPI--
    GO:0005525GTP binding IDA--
         
    RAB1B for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RAB1B:
     Decreased Tat-dependent transc 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Rab1b):
     normal 

    RAB1B for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RAB1B 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RAB1B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RAB1B 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RAB1B 

    miRNA
    Products:
        
    miRTarBase miRNAs that target RAB1B:
    hsa-mir-107 (MIRT004695)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAB1B
    8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate RAB1B (see all 32):
    hsa-miR-676 hsa-miR-502-5p hsa-miR-300 hsa-miR-1197 hsa-miR-3660 hsa-miR-331-3p hsa-miR-103a hsa-miR-105
    SwitchGear 3'UTR luciferase reporter plasmidRAB1B 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RAB1B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAB1B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RAB1B
    Sirion Biotech Customized adenovirus for overexpression of RAB1B

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for RAB1B (see all 7)
    OriGene ORF clones in mouse, rat for RAB1B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RAB1B (NM_030981)
    Sino Biological Human cDNA Clone for RAB1B
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAB1B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB1B
    Sirion Biotech Customized lentivirus for stable overexpression of RAB1B 
                         Customized lentivirus expression plasmids for stable overexpression of RAB1B 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RAB1B
    Search LifeMap BioReagents cell lines for RAB1B
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB1B


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RAB1B About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1M Phase
    M Phase0.88
    Mitotic M-M/G1 phases0.88
    2Cell Cycle
    Cell Cycle, Mitotic0.84
    Cell Cycle0.84
    3Regulation of Glucokinase by Glucokinase Regulatory Protein
    Mitotic Prophase0.70
    4Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions0.36
    5Legionellosis
    Legionellosis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RAB1B
        Epithelial Tight Junctions


    5/6        Reactome Pathways for RAB1B (see all 6)
        Golgi Cisternae Pericentriolar Stack Reorganization
    Mitotic Prophase
    Cell Cycle
    M Phase
    Mitotic M-M/G1 phases


    1         Kegg Pathway  (Kegg details for RAB1B):
        Legionellosis


    RAB1B for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAB1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/19 Interacting proteins for RAB1B (Q9H0U42, 3 ENSP000003102264) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RUSC2Q8N2Y82, 3, ENSP000003551774MINT-61270 MINT-61269 MINT-61266 I2D: score=3 STRING: ENSP00000355177
    GOLGA2Q083792, 3, ENSP000004160974MINT-61265 I2D: score=3 STRING: ENSP00000416097
    MICAL1Q8TDZ22, 3, ENSP000003516644MINT-61264 I2D: score=3 STRING: ENSP00000351664
    OCRLQ019682MINT-8184698 MINT-8184889 MINT-8184876
    CHMP243863, ENSP000003503864I2D: score=2 STRING: ENSP00000350386
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process ----
    GO:0006886intracellular protein transport ----
    GO:0006913nucleocytoplasmic transport ----
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction IEA--

    RAB1B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RAB1B for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RAB1B

    1 HMDB Compound for RAB1B    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    2 Novoseek inferred chemical compound relationships for RAB1B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gdp 67.1 3 8325834 (1), 9437002 (1), 8836150 (1)
    gtp 56.7 1 8325834 (1)

    Search CenterWatch for drugs/clinical trials and news about RAB1B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RAB1B gene: 
    NM_030981.2  

    Unigene Cluster for RAB1B:

    RAB1B, member RAS oncogene family
    Hs.300816  [show with all ESTs]
    Unigene Representative Sequence: AK125412
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000311481(uc001ohf.3) ENST00000527397
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAB1B
    8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate RAB1B (see all 32):
    hsa-miR-676 hsa-miR-502-5p hsa-miR-300 hsa-miR-1197 hsa-miR-3660 hsa-miR-331-3p hsa-miR-103a hsa-miR-105
    SwitchGear 3'UTR luciferase reporter plasmidRAB1B 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RAB1B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAB1B
    Clone
    Products:
         
    OriGene clones in human, mouse for RAB1B (see all 7)
    OriGene ORF clones in mouse, rat for RAB1B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RAB1B (NM_030981)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAB1B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB1B
    Sirion Biotech Customized lentivirus for stable overexpression of RAB1B 
                         Customized lentivirus expression plasmids for stable overexpression of RAB1B 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RAB1B
    OriGene qSTAR qPCR primer pairs in human, mouse for RAB1B
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RAB1B
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAB1B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAB1B

    Additional mRNA sequence: 

    AJ245875.1 AK125412.1 AK292086.1 AK315333.1 AL136635.1 BC028331.1 BC071169.1 CR533462.1 
    U66621.1 

    24/28 DOTS entries (see all 28):

    DT.100786824  DT.91908062  DT.100757341  DT.121192845  DT.99998569  DT.120735097  DT.120735063  DT.216580 
    DT.92041333  DT.100786834  DT.91652303  DT.91867251  DT.92450775  DT.95177030  DT.97864437  DT.99985353 
    DT.100770591  DT.100786826  DT.100786831  DT.120735110  DT.91695929  DT.92450787  DT.92450794  DT.95177025 

    24/705 AceView cDNA sequences (see all 705):

    BM916989 BM560456 BI906801 BF064130 BM703149 CR592347 BX464226 BM930036 
    BU931639 BQ939693 BF875068 CA393447 BQ439027 BM476064 BQ932462 CR625419 
    AA434103 BQ941767 AK094593 AA375777 AL524584 AW733009 BM811149 CR624810 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for RAB1B    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
    SP1:                                          
    SP2:                    -                     


    ECgene alternative splicing isoforms for RAB1B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RAB1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAGGCATTT
    RAB1B Expression
    About this image


    See RAB1B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RAB1B

    SOURCE GeneReport for Unigene cluster: Hs.300816
        SABiosciences Custom PCR Arrays for RAB1B
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RAB1B
    OriGene qSTAR qPCR primer pairs in human, mouse for RAB1B
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RAB1B
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAB1B
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAB1B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB1B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RAB1B gene from 8/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rab1b1 , 5 RAB1B, member RAS oncogene family1, 5 91.21(n)1
    99(a)1
      19 (4.25 cM)5
    763081  NM_029576.31  NP_083852.11 
     50992075 
    lizard
    (Anolis carolinensis)
    Reptilia RAB1B6
    --
    Uncharacterized protein
    75(a)
    75(a)
    1 ↔ 1
    possible ortholog
    GL343635.1(211685-218143)
    GL343519.1(94185-105647)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc560492 similar to RAB1, member RAS oncogene family 81.37(n)   394117  BC047816.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rab13 Rho small monomeric GTPase 83(a)
    (best of 3)
      93D2   --
    worm
    (Caenorhabditis elegans)
    Secernentea rab-13   -- 79(a)
    (best of 4)
      V(1262845-1263838)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YPT16
    Rab family GTPase, involved in the ER-to-Golgi ste...
    68(a)
    1 → many
    VI(55366-55986)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons RA-51 Ras-related protein RABD2A 64.33(n)
    76.5(a)
      837023  NM_100093.3  NP_171715.1 
    rice
    (Oryza sativa)
    Liliopsida Os.78692 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 78.09(n)    NM_189540.1 


    ENSEMBL Gene Tree for RAB1B (if available)
    TreeFam Gene Tree for RAB1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RAB1B gene
    RAB102  RAB3B2  RAB27B2  RAB8A2  RAB3D2  RAB3A2  RAB352  RAB27A2  
    RAB8B2  RAB122  RAB1A2  RAB132  RAB3C2  
    18/103 SIMAP similar genes for RAB1B using alignment to 3 protein entries:     RAB1B_HUMAN (see all proteins) (see all similar genes):
    rab1b    RAB1C    RAB8B    DKFZp686J07132    RAB1A    RAB3A
    RAB30    RAB36    RAB10    RAB8A    RAB13    RAB43
    RAB33A    NRAS    RAB6A'    RAB15    RAB39B    RAB5C

    RAB1B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/170 SNPs in RAB1B are shown (see all 170)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1121954091,2
    C--66035866(+) CAAGCC/TTGAGT 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs38147391,2
    C,F,H--66035979(-) TCTCCA/GACTCA 1 -- us2k120Minor allele frequency- G:0.29EA MN NS NA WA 4106
    rs112274401,2
    C--66036041(+) GACGTT/GTGCGC 1 -- us2k13Minor allele frequency- G:0.08NA WA 122
    rs1996567421,2
    C--66036141(+) GCCGCC/TGCCGC 1 -- ut510--------
    rs1506274441,2
    C--66036293(+) GCTGA-/CCCCCCC 1 -- int10--------
    rs1877046081,2
    --66036435(+) CCAGGC/TCTTAT 1 -- int10--------
    rs1178270121,2
    F--66036564(+) TGGGCC/TCTTTA 1 -- int11Minor allele frequency- T:0.05NA 120
    rs1510239851,2
    --66036852(+) TTTAGA/TTGAAT 1 -- int10--------
    rs1932289921,2
    --66036858(+) TGAATA/GTGGAA 1 -- int10--------
    rs743949701,2
    F--66037040(+) TCTCAG/CATTTC 1 -- int11Minor allele frequency- C:0.01WA 118

    HapMap Linkage Disequilibrium report for RAB1B (66036004 - 66044963 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for RAB1B:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv897772CNV Loss21882294
    dgv1187n71CNV Loss21882294
    dgv1188n71CNV Loss21882294
    nsv825955CNV Gain20364138

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RAB1B
    DNA2.0 Custom Variant and Variant Library Synthesis for RAB1B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612565    OMIM disorders: --

    5 diseases for RAB1B:    About MalaCards
    legionnaires' disease    platelet storage pool deficiency    rabies    herpes simplex
    melanoma

    1 disease from the University of Copenhagen DISEASES database for RAB1B:
    Platelet storage pool deficiency

    RAB1B for disorders           About GeneDecksing

    Genetic Association Database (GAD): RAB1B
    Human Genome Epidemiology (HuGE) Navigator: RAB1B (1 document)

    Export disorders for RAB1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RAB1B gene, integrated from 9 sources (see all 62):
    (articles sorted by number of sources associating them with RAB1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The putative 'switch 2' domain of the Ras-related GTPase, Rab1B, plays an essential role in the interaction with Rab escort protein. (PubMed id 9437002)1, 2, 9 Overmeyer J.H.... Maltese W.A. (1998)
    2. Prenylation of a Rab1B mutant with altered GTPase activity is impaired in cell-free systems but not in intact mammalian cells. (PubMed id 8836150)1, 2, 9 Wilson A.L.... Maltese W.A. (1996)
    3. The MICAL proteins and rab1: a possible link to the cytoskeleton? (PubMed id 15694364)1, 2 Fischer J.... Barnekow A. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    6. RAB GTPases expressed in human melanoma cells. (PubMed id 9030196)1, 3 Chen D.... Gahl W.A. (1997)
    7. Mechanism of Rab1b deactivation by the Legionella pneu mophila GAP LepB. (PubMed id 23288104)1 Mihai Gazdag E....Itzen A. (2013)
    8. Bcl2-associated Athanogene 3 Interactome Analysis Reve als a New Role in Modulating Proteasome Activity. (PubMed id 23824909)1 Chen Y....Ge F. (2013)
    9. Phosphatidylinositol 3-phosphatase myotubularin-relate d protein 6 (MTMR6) is regulated by small GTPase Rab1B in the early secretory an d autophagic pathways. (PubMed id 23188820)1 Mochizuki Y....Hamakubo T. (2013)
    10. Rab1b overexpression modifies Golgi size and gene expr ession in HeLa cells and modulates the thyrotrophin response in thyroid cells in culture. (PubMed id 23325787)1 Romero N....Alvarez C. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 81876 HGNC: 18370 AceView: KLC2andRAB1B Ensembl:ENSG00000174903 euGenes: HUgn81876
    ECgene: RAB1B Kegg: 81876 H-InvDB: RAB1B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RAB1B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAB1B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RAB1B gene:
    Search GeneIP for patents involving RAB1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for RAB1B  
     OriGene qPCR primer pairs and template standards for RAB1B   OriGene Protein Over-expression Lysate for RAB1B  
     OriGene MassSpec something-or-other for RAB1B   OriGene clones in human, mouse for RAB1B  
     OriGene qSTAR qPCR primer pairs in human, mouse for RAB1B   OriGene Purified Protein for RAB1B  
     OriGene ORF clones in mouse, rat for RAB1B   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RAB1B   OriGene Custom Protein Services for RAB1B  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RAB1B
     QIAGEN SeqTarget long-range PCR primers for resequencing RAB1B
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB1B
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAB1B
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAB1B
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAB1B
     GenScript Custom Purified and Recombinant Proteins Services for RAB1B GenScript cDNA clones with any tag delivered in your preferred vector for RAB1B
     GenScript Custom Assay Services for RAB1B GenScript Custom Superior Antibodies Services for RAB1B
     GenScript Custom overexpressing Cell Line Services for RAB1B CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in RAB1B promoter
     Search Chromatin IP Primers for RAB1B
     RT2 qPCR Primer Assay in human, mouse, rat RAB1B
     GNC Network for RAB1B
     SABiosciences PCR Arrays including human, mouse, rat RAB1B
     Search Tocris compounds for RAB1B
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for RAB1B
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     RAB1B antibodies
     RAB1B proteins
     RAB1B lysates
     Antibodies for RAB1B
     See all of Abcam's Antibodies, Kits and Proteins for RAB1B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for RAB1B




     Proteins for RAB1B
     Antibodies for RAB1B
     ELISAs for RAB1B
     CLIAs for RAB1B
     Search LifeMap BioReagents cell lines for RAB1B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB1B
     SwitchGear 3'UTR luciferase reporter plasmids for RAB1B
     SwitchGear Promoter luciferase reporter plasmids for RAB1B
     Search ThermoFisher Antibodies for RAB1B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB1B
     inGenious Targeting Laboratory - Custom generated mouse model solutions for RAB1B
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RAB1B
    Customized:
     lentivirus for stable overexpression of RAB1B
     lentivirus expression plasmids for stable overexpression of RAB1B
     adenovirus for overexpression of RAB1B
     LSBio Antibodies in human, mouse, rat for RAB1B
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RAB1B gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4