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Aliases for RAB1B Gene

Aliases for RAB1B Gene

  • RAB1B, Member RAS Oncogene Family 2 3

External Ids for RAB1B Gene

Previous GeneCards Identifiers for RAB1B Gene

  • GC11P068570
  • GC11P067717
  • GC11P066285
  • GC11P065811
  • GC11P065792
  • GC11P065777
  • GC11P066036
  • GC11P062361

Summaries for RAB1B Gene

Entrez Gene Summary for RAB1B Gene

  • Members of the RAB protein family, such as RAB1B, are low molecular mass monomeric GTPases localized on the cytoplasmic surfaces of distinct membrane-bound organelles. RAB1B functions in the early secretory pathway and is essential for vesicle transport between the endoplasmic reticulum (ER) and Golgi (Chen et al., 1997 [PubMed 9030196]; Alvarez et al., 2003 [PubMed 12802079]).[supplied by OMIM, Jan 2009]

GeneCards Summary for RAB1B Gene

RAB1B (RAB1B, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB1B include platelet storage pool deficiency. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include GTP binding. An important paralog of this gene is RAB37.

UniProtKB/Swiss-Prot for RAB1B Gene

  • The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1B regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments. Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum.

Gene Wiki entry for RAB1B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB1B Gene

Genomics for RAB1B Gene

Regulatory Elements for RAB1B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RAB1B Gene

Start:
66,268,533 bp from pter
End:
66,277,492 bp from pter
Size:
8,960 bases
Orientation:
Plus strand

Genomic View for RAB1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAB1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB1B Gene

Proteins for RAB1B Gene

  • Protein details for RAB1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0U4-RAB1B_HUMAN
    Recommended name:
    Ras-related protein Rab-1B
    Protein Accession:
    Q9H0U4
    Secondary Accessions:
    • A8K7S1

    Protein attributes for RAB1B Gene

    Size:
    201 amino acids
    Molecular mass:
    22171 Da
    Quaternary structure:
    • Interacts with MICAL1, MICAL2 and MICAL3. Interacts with GDI1; the interaction requires the GDP-bound state. Interacts with CHM/REP1; the interaction requires the GDP-bound form and is necessary for prenylation by GGTase II.
    Miscellaneous:
    • Rab-1B binds GTP and GDP and possesses low intrinsic GTPase activity

    Three dimensional structures from OCA and Proteopedia for RAB1B Gene

neXtProt entry for RAB1B Gene

Proteomics data for RAB1B Gene at MOPED

Post-translational modifications for RAB1B Gene

  • AMPylation at Tyr-77 by L.pneumophila DrrA occurs in the switch 2 region and leads to moderate inactivation of the GTPase activity. It appears to prolong the lifetime of the GTP state of RAB1B by restricting access of GTPase effectors to switch 2 and blocking effector-stimulated GTP hydrolysis, thereby rendering RAB1B constitutively active. It is later de-AMPylated by L.pneumophila SidD, releasing RAB1B from bacterial phagosomes.
  • Phosphocholinated at Ser-76 by L.pneumophila AnkX, leading to displace GDP dissociation inhibitors (GDI). Both GDP-bound and GTP-bound forms can be phosphocholinated. Dephosphocholinated by L.pneumophila Lem3, restoring accessibility to L.pneumophila GTPase effector LepB
  • Prenylated; by GGTase II, only after interaction of the substrate with Rab escort protein 1 (REP1).
  • Ubiquitination at Lys21 and Lys116
  • Modification sites at PhosphoSitePlus

Other Protein References for RAB1B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RAB1B Gene

Domains for RAB1B Gene

Gene Families for RAB1B Gene

HGNC:
  • RAB :RAB, member RAS oncogene

Suggested Antigen Peptide Sequences for RAB1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H0U4

UniProtKB/Swiss-Prot:

RAB1B_HUMAN :
  • Q9H0U4
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB1B: view

Function for RAB1B Gene

Molecular function for RAB1B Gene

UniProtKB/Swiss-Prot EnzymeRegulation: Rab activation is generally mediated by a guanine exchange factor (GEF), while inactivation through hydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP).
UniProtKB/Swiss-Prot Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1B regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments. Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum.

Gene Ontology (GO) - Molecular Function for RAB1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IBA --
GO:0005515 protein binding IPI 15796781
GO:0005525 GTP binding IDA 20937701
genes like me logo Genes that share ontologies with RAB1B: view

Phenotypes for RAB1B Gene

MGI mutant phenotypes for RAB1B:
inferred from 1 alleles
GenomeRNAi human phenotypes for RAB1B:
genes like me logo Genes that share phenotypes with RAB1B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAB1B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RAB1B Gene

Localization for RAB1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB1B Gene

Cytoplasm. Membrane; Lipid-anchor; Cytoplasmic side. Preautophagosomal structure membrane; Lipid-anchor; Cytoplasmic side. Note=Targeted by REP1 to membranes of specific subcellular compartments including endoplasmic reticulum, Golgi apparatus, and intermediate vesicles between these two compartments. In the GDP-form, colocalizes with GDI in the cytoplasm (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB1B Gene COMPARTMENTS Subcellular localization image for RAB1B gene
Compartment Confidence
golgi apparatus 4
cytosol 3
cytoskeleton 2
endoplasmic reticulum 2
endosome 2
mitochondrion 2
nucleus 2
plasma membrane 2
vacuole 2
extracellular 1
lysosome 1

Gene Ontology (GO) - Cellular Components for RAB1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IBA --
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005737 cytoplasm --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with RAB1B: view

Pathways for RAB1B Gene

genes like me logo Genes that share pathways with RAB1B: view

Pathways by source for RAB1B Gene

1 KEGG pathway for RAB1B Gene

Gene Ontology (GO) - Biological Process for RAB1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport IBA --
GO:0006888 ER to Golgi vesicle-mediated transport IGI 21680502
GO:0006913 nucleocytoplasmic transport --
GO:0006914 autophagy IEA --
genes like me logo Genes that share ontologies with RAB1B: view

Compounds for RAB1B Gene

(1) HMDB Compounds for RAB1B Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1

(2) Novoseek inferred chemical compound relationships for RAB1B Gene

Compound -log(P) Hits PubMed IDs
gdp 67.1 3
gtp 56.7 1
genes like me logo Genes that share compounds with RAB1B: view

Transcripts for RAB1B Gene

mRNA/cDNA for RAB1B Gene

Unigene Clusters for RAB1B Gene

RAB1B, member RAS oncogene family:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAB1B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB1B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1:
SP2: -

Relevant External Links for RAB1B Gene

GeneLoc Exon Structure for
RAB1B
ECgene alternative splicing isoforms for
RAB1B

Expression for RAB1B Gene

mRNA expression in normal human tissues for RAB1B Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB1B Gene

SOURCE GeneReport for Unigene cluster for RAB1B Gene Hs.300816

genes like me logo Genes that share expressions with RAB1B: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RAB1B Gene

Orthologs for RAB1B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RAB1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB1B 35
  • 99.83 (n)
  • 100 (a)
RAB1B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RAB1B 35
  • 94.36 (n)
  • 99.5 (a)
RAB1B 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 85 (a)
OneToMany
-- 36
  • 99 (a)
OneToMany
RAB1B 35
  • 93.7 (n)
  • 100 (a)
mouse
(Mus musculus)
Mammalia Rab1b 35
  • 91.21 (n)
  • 99 (a)
Rab1b 16
Rab1b 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAB1B 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rab1b 35
  • 90.38 (n)
  • 98.51 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 75 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2074 35
zebrafish
(Danio rerio)
Actinopterygii rab1ba 35
  • 80.93 (n)
  • 94.03 (a)
rab1ba 36
  • 94 (a)
OneToMany
rab1bb 36
  • 92 (a)
OneToMany
zgc56049 35
fruit fly
(Drosophila melanogaster)
Insecta Rab1 36
  • 82 (a)
OneToMany
CG2885 37
  • 46 (a)
Rab1 37
  • 83 (a)
Rab-RP3 37
  • 50 (a)
worm
(Caenorhabditis elegans)
Secernentea rab-1 36
  • 80 (a)
OneToMany
4R79.2 37
  • 37 (a)
rab-1 37
  • 79 (a)
C33D12.6 37
  • 38 (a)
K02E10.1 37
  • 40 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPT1 36
  • 68 (a)
OneToMany
barley
(Hordeum vulgare)
Liliopsida Hv.3870 35
corn
(Zea mays)
Liliopsida Zm.5901 35
rice
(Oryza sativa)
Liliopsida Os.7869 35
wheat
(Triticum aestivum)
Liliopsida Ta.2042 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10592 36
  • 86 (a)
OneToMany
Species with no ortholog for RAB1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)

Evolution for RAB1B Gene

ENSEMBL:
Gene Tree for RAB1B (if available)
TreeFam:
Gene Tree for RAB1B (if available)

Paralogs for RAB1B Gene

Paralogs for RAB1B Gene

genes like me logo Genes that share paralogs with RAB1B: view

Variants for RAB1B Gene

Sequence variations from dbSNP and Humsavar for RAB1B Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs524859 -- 66,273,608(+) GCATG(A/G)CTGCG intron-variant
rs554459 -- 66,269,848(+) CTCAA(G/T)TATAT intron-variant
rs555826 -- 66,272,582(-) TCCTG(C/T)AAGCA intron-variant
rs555853 -- 66,272,578(-) GTAAG(C/G)AGACA intron-variant
rs576470 -- 66,269,941(+) gtgac(A/G)atggc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB1B Gene

Variant ID Type Subtype PubMed ID
dgv1187n71 CNV Loss 21882294
nsv897772 CNV Loss 21882294
nsv825955 CNV Gain 20364138
dgv1188n71 CNV Loss 21882294

Relevant External Links for RAB1B Gene

HapMap Linkage Disequilibrium report
RAB1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB1B Gene

Disorders for RAB1B Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for RAB1B Gene including...

Search for RAB1B Gene in MalaCards »

(1) University of Copenhagen DISEASES for RAB1B Gene

Relevant External Links for RAB1B

Genetic Association Database (GAD)
RAB1B
Human Genome Epidemiology (HuGE) Navigator
RAB1B
genes like me logo Genes that share disorders with RAB1B: view

No data available for UniProtKB/Swiss-Prot for RAB1B Gene

Publications for RAB1B Gene

  1. Prenylation of a Rab1B mutant with altered GTPase activity is impaired in cell-free systems but not in intact mammalian cells. (PMID: 8836150) Wilson A.L. … Maltese W.A. (Biochem. J. 1996) 3 4 23
  2. The putative 'switch 2' domain of the Ras-related GTPase, Rab1B, plays an essential role in the interaction with Rab escort protein. (PMID: 9437002) Overmeyer J.H. … Maltese W.A. (Mol. Biol. Cell 1998) 3 4 23
  3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  4. RAB GTPases expressed in human melanoma cells. (PMID: 9030196) Chen D. … Gahl W.A. (Biochim. Biophys. Acta 1997) 2 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for RAB1B Gene

Sources for RAB1B Gene

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