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RAB1B Gene

protein-coding   GIFtS: 64
GCID: GC11P066036

RAB1B, Member RAS Oncogene Family

Pneumococci & Pneumococcal Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RAB1B, Member RAS Oncogene Family1 2
Ras-Related Protein Rab-1B2
Small GTP-Binding Protein2

External Ids:    HGNC: 183701   Entrez Gene: 818762   Ensembl: ENSG000001749037   OMIM: 6125655   UniProtKB: Q9H0U43   

Export aliases for RAB1B gene to outside databases

Previous GC identifers: GC11P068570 GC11P067717 GC11P066285 GC11P065811 GC11P065792 GC11P065777 GC11P062361


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RAB1B Gene:
Members of the RAB protein family, such as RAB1B, are low molecular mass monomeric GTPases localized on the
cytoplasmic surfaces of distinct membrane-bound organelles. RAB1B functions in the early secretory pathway and is
essential for vesicle transport between the endoplasmic reticulum (ER) and Golgi (Chen et al., 1997 (PubMed
9030196); Alvarez et al., 2003 (PubMed 12802079)).(supplied by OMIM, Jan 2009)

GeneCards Summary for RAB1B Gene:
RAB1B (RAB1B, member RAS oncogene family) is a protein-coding gene. Diseases associated with RAB1B include legionnaires' disease, and legionellosis. GO annotations related to this gene include GTP binding. An important paralog of this gene is RAB10.

UniProtKB/Swiss-Prot: RAB1B_HUMAN, Q9H0U4
Function: Protein transport. Regulates vesicular transport between the endoplasmic reticulum and successive Golgi
compartments

Gene Wiki entry for RAB1B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RAB1B gene promoter:
         E2F-4   E2F-3a   E2F-5   MAZR   E2F-2   LCR-F1   c-Ets-1   AREB6   E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRAB1B promoter sequence
   Search Chromatin IP Primers for RAB1B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RAB1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12   Ensembl cytogenetic band:  11q13.2   HGNC cytogenetic band: 11q13.1

RAB1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAB1B gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P066036:  view genomic region     (about GC identifiers)

Start:
66,036,004 bp from pter      End:
66,044,963 bp from pter
Size:
8,960 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RAB1B_HUMAN, Q9H0U4 (See protein sequence)
Recommended Name: Ras-related protein Rab-1B  
Size: 201 amino acids; 22171 Da
Subunit: Interacts with MICAL1, MICAL2 and MICAL3. Interacts with GDI1; the interaction requires the GDP-bound
state. Interacts with CHM/REP1; the interaction requires the GDP-bound form and is necessary for prenylation by
GGTase II
Miscellaneous: Rab-1B binds GTP and GDP and possesses intrinsic GTPase activity (By similarity)
4 PDB 3D structures from and Proteopedia for RAB1B:
3JZA (3D)        3NKV (3D)        4HLQ (3D)        4I1O (3D)    
Secondary accessions: A8K7S1

Explore the universe of human proteins at neXtProt for RAB1B: NX_Q9H0U4

Explore proteomics data for RAB1B at MOPED

Post-translational modifications: 

  • Prenylated; by GGTase II, only after interaction of the substrate with Rab escort protein 1 (REP1)1
  • AMPylation at Tyr-77 by L.pneumophila DrrA occurs in the switch 2 region and leads to moderate inactivation of the
    GTPase activity. It appears to prolong the lifetime of the GTP state of RAB1B by restricting access of GTPase
    effectors to switch 2 and blocking effector-stimulated GTP hydrolysis, thereby rendering RAB1B constitutively
    active. It is later de-AMPylated by L.pneumophila SidD, releasing RAB1B from bacterial phagosomes1
  • Phosphocholinated at Ser-76 by L.pneumophila AnkX, leading to displace GDP dissociation inhibitors (GDI). Both
    GDP-bound and GTP-bound forms can be phosphocholinated. Dephosphocholinated by L.pneumophila Lem3, restoring
    accessibility to L.pneumophila GTPase effector LepB1
  • Ubiquitination2 at Lys21, Lys116
  • Modification sites at PhosphoSitePlus

  • See RAB1B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_112243.1  
    ENSEMBL proteins: 
     ENSP00000310226   ENSP00000435195  
    Reactome Protein details: Q9H0U4

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RAB: RAB, member RAS oncogene

    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR003579 Small_GTPase_Rab_type
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q9H0U4

    ProtoNet protein and cluster: Q9H0U4

    1 Blocks protein domain: IPB001806 Transforming protein P21 RAS signature

    UniProtKB/Swiss-Prot: RAB1B_HUMAN, Q9H0U4
    Similarity: Belongs to the small GTPase superfamily. Rab family


    RAB1B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RAB1B_HUMAN, Q9H0U4
    Function: Protein transport. Regulates vesicular transport between the endoplasmic reticulum and successive Golgi
    compartments

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity ----
    GO:0005515protein binding IPI--
    GO:0005525GTP binding IDA--
         
    RAB1B for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RAB1B:
     Decreased Tat-dependent transc 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Rab1b):
     normal 

    RAB1B for phenotypes           About GeneDecksing

    Animal Models:
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    Block miRNA regulation of human, mouse, rat RAB1B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RAB1B (see all 32):
    hsa-miR-676 hsa-miR-502-5p hsa-miR-300 hsa-miR-1197 hsa-miR-3660 hsa-miR-331-3p hsa-miR-103a hsa-miR-105
    SwitchGear 3'UTR luciferase reporter plasmidRAB1B 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RAB1B_HUMAN, Q9H0U4: Membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm. Note=Targeted by REP1 to membranes of
    specific subcellular compartments including endoplasmic reticulum, Golgi apparatus, and intermediate vesicles
    between these two compartments. In the GDP-form, colocalizes with GDI in the cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus4
    cytosol3
    cytoskeleton2
    endoplasmic reticulum2
    endosome2
    mitochondrion2
    nucleus2
    plasma membrane2
    vacuole2
    extracellular1
    lysosome1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion IEA--
    GO:0005794Golgi apparatus IDA--

    RAB1B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RAB1B About    
    See pathways by source

    SuperPathContained pathways About
    1Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    2RNA Polymerase I Promoter Opening
    Mitotic Prophase0.56
    Golgi Cisternae Pericentriolar Stack Reorganization0.00
    3Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions0.36
    4Legionellosis
    Legionellosis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for RAB1B
        Epithelial Tight Junctions


    1 Reactome Pathway for RAB1B
        Golgi Cisternae Pericentriolar Stack Reorganization


    1 Kegg Pathway  (Kegg details for RAB1B):
        Legionellosis


    RAB1B for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RAB1B
    Interactions:

        GeneGlobe Interaction Network for RAB1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RAB1B (Q9H0U41, 2, 3 ENSP000003102264) via UniProtKB, MINT, STRING, and/or I2D (see all 149)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OCRLQ019681, 2EBI-1045214,EBI-6148898 MINT-8184698 MINT-8184889 MINT-8184876
    GOLGA2Q083792, 3, ENSP000004160974MINT-61265 I2D: score=3 STRING: ENSP00000416097
    RUSC2Q8N2Y82, 3, ENSP000003551774MINT-61270 MINT-61269 MINT-61266 I2D: score=3 STRING: ENSP00000355177
    MICAL1Q8TDZ22, 3, ENSP000003516644MINT-61264 I2D: score=3 STRING: ENSP00000351664
    GDI1P311503, ENSP000003940714I2D: score=2 STRING: ENSP00000394071
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process ----
    GO:0006886intracellular protein transport ----
    GO:0006913nucleocytoplasmic transport ----
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction IEA--

    RAB1B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RAB1B

    1 HMDB Compound for RAB1B    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    2 Novoseek inferred chemical compound relationships for RAB1B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gdp 67.1 3 8325834 (1), 9437002 (1), 8836150 (1)
    gtp 56.7 1 8325834 (1)



    RAB1B for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RAB1B gene: 
    NM_030981.2  

    Unigene Cluster for RAB1B:

    RAB1B, member RAS oncogene family
    Hs.300816  [show with all ESTs]
    Unigene Representative Sequence: AK125412
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000311481(uc001ohf.3) ENST00000527397

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    hsa-miR-676 hsa-miR-502-5p hsa-miR-300 hsa-miR-1197 hsa-miR-3660 hsa-miR-331-3p hsa-miR-103a hsa-miR-105
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    Additional mRNA sequence: 

    AJ245875.1 AK125412.1 AK292086.1 AK315333.1 AL136635.1 BC028331.1 BC071169.1 CR533462.1 
    U66621.1 

    Selected DOTS entries (see all 28):

    DT.100786824  DT.91908062  DT.100757341  DT.121192845  DT.99998569  DT.120735097  DT.120735063  DT.216580 
    DT.92041333  DT.100786834  DT.91652303  DT.91867251  DT.92450775  DT.95177030  DT.97864437  DT.99985353 
    DT.100770591  DT.100786826  DT.100786831  DT.120735110  DT.91695929  DT.92450787  DT.92450794  DT.95177025 

    Selected AceView cDNA sequences (see all 705):

    BI913561 BQ052587 BM930036 CR620997 AI284573 BF064130 BQ939693 BX464225 
    BU552578 BG826700 AL136864 BI753331 BI522605 BC034373 BM476064 BM703546 
    BG114309 AW002759 BE730933 AA375777 BM811154 BU956091 U66621 CA489174 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for RAB1B    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
    SP1:                                          
    SP2:                    -                     


    ECgene alternative splicing isoforms for RAB1B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RAB1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAGGCATTT
    RAB1B Expression
    About this image

    RAB1B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RAB1B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.300816
        Custom PCR Arrays for RAB1B
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RAB1B gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rab1b1 , 5 RAB1B, member RAS oncogene family1, 5 91.21(n)1
    99(a)1
      19 (4.25 cM)5
    763081  NM_029576.31  NP_083852.11 
     50992075 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    75(a)
    1 → many
    GL343519.1(94185-105647)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc560492 similar to RAB1, member RAS oncogene family 81.37(n)   394117  BC047816.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rab13 Rho small monomeric GTPase 83(a)
    (best of 3)
      93D2   --
    worm
    (Caenorhabditis elegans)
    Secernentea rab-13   -- 79(a)
    (best of 4)
      V(1262845-1263838)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YPT16
    Rab family GTPase, involved in the ER-to-Golgi ste...
    68(a)
    1 → many
    VI(55366-55986) YFL038C
    soybean
    (Glycine max)
    eudicotyledons BE661071.12   -- 79.47(n)    BE661071.1 
    rice
    (Oryza sativa)
    Liliopsida Os.78692 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 78.09(n)    NM_189540.1 


    ENSEMBL Gene Tree for RAB1B (if available)
    TreeFam Gene Tree for RAB1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RAB1B gene
    RAB102  RAB3B2  RAB262  RAB8A2  RAB3D2  RAB372  RAB3A2  RAB8B2  
    RAB122  RAB1A2  RAB132  RAB3C2  
    Selected SIMAP similar genes for RAB1B using alignment to 3 protein entries:     RAB1B_HUMAN (see all proteins) (see all similar genes):
    rab1b    RAB1C    RAB8B    DKFZp686J07132    RAB1A    RAB3A
    RAB30    RAB36    RAB10    RAB8A    RAB13    RAB43
    RAB33A    NRAS    RAB6A'    RAB15    RAB39B    RAB5C

    RAB1B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RAB1B (see all 170)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1121954091,2
    C--66035866(+) CAAGCC/TTGAGT 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs38147391,2
    C,F,H--66035979(-) TCTCCA/GACTCA 1 -- us2k120Minor allele frequency- G:0.29EA MN NS NA WA 4106
    rs112274401,2
    C--66036041(+) GACGTT/GTGCGC 1 -- us2k13Minor allele frequency- G:0.08NA WA 122
    rs1996567421,2
    C--66036141(+) GCCGCC/TGCCGC 1 -- ut510--------
    rs1506274441,2
    C--66036293(+) GCTGA-/CCCCCCC 1 -- int10--------
    rs1877046081,2
    --66036435(+) CCAGGC/TCTTAT 1 -- int10--------
    rs1178270121,2
    F--66036564(+) TGGGCC/TCTTTA 1 -- int11Minor allele frequency- T:0.05NA 120
    rs1510239851,2
    --66036852(+) TTTAGA/TTGAAT 1 -- int10--------
    rs1932289921,2
    --66036858(+) TGAATA/GTGGAA 1 -- int10--------
    rs743949701,2
    F--66037040(+) TCTCAG/CATTTC 1 -- int11Minor allele frequency- C:0.01WA 118

    HapMap Linkage Disequilibrium report for RAB1B (66036004 - 66044963 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for RAB1B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv897772CNV Loss21882294
    dgv1187n71CNV Loss21882294
    dgv1188n71CNV Loss21882294
    nsv825955CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RAB1B
    DNA2.0 Custom Variant and Variant Library Synthesis for RAB1B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612565    OMIM disorders: --

    9 diseases for RAB1B:    
    About MalaCards
    legionnaires' disease    legionellosis    platelet storage pool deficiency    rabies
    herpes simplex    bipolar disorder    melanoma    hiv-1
    thyroiditis

    1 disease from the University of Copenhagen DISEASES database for RAB1B:
    Platelet storage pool deficiency

    RAB1B for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Genetic Association Database (GAD): RAB1B
    Human Genome Epidemiology (HuGE) Navigator: RAB1B (1 document)

    Export disorders for RAB1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RAB1B gene, integrated from 10 sources (see all 63):
    (articles sorted by number of sources associating them with RAB1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The putative 'switch 2' domain of the Ras-related GTPase, Rab1B, plays an essential role in the interaction with Rab escort protein. (PubMed id 9437002)1, 2, 9 Overmeyer J.H.... Maltese W.A. (Mol. Biol. Cell 1998)
    2. Prenylation of a Rab1B mutant with altered GTPase activity is impaired in cell-free systems but not in intact mammalian cells. (PubMed id 8836150)1, 2, 9 Wilson A.L.... Maltese W.A. (Biochem. J. 1996)
    3. The MICAL proteins and rab1: a possible link to the cytoskeleton? (PubMed id 15694364)1, 2 Fischer J.... Barnekow A. (Biochem. Biophys. Res. Commun. 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    6. RAB GTPases expressed in human melanoma cells. (PubMed id 9030196)1, 3 Chen D.... Gahl W.A. (Biochim. Biophys. Acta 1997)
    7. Mechanism of Rab1b deactivation by the Legionella pneumophila GAP LepB. (PubMed id 23288104)1 Mihai Gazdag E....Itzen A. (EMBO Rep. 2013)
    8. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)1 Chen Y....Ge F. (amp 2013)
    9. Phosphatidylinositol 3-phosphatase myotubularin-related protein 6 (MTMR6) is regulated by small GTPase Rab1B in the early secretory and autophagic pathways. (PubMed id 23188820)1 Mochizuki Y....Hamakubo T. (J. Biol. Chem. 2013)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 81876 HGNC: 18370 AceView: KLC2andRAB1B Ensembl:ENSG00000174903 euGenes: HUgn81876
    ECgene: RAB1B Kegg: 81876 H-InvDB: RAB1B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RAB1B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAB1B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RAB1B gene:
    Search GeneIP for patents involving RAB1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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