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Aliases for RAB1A Gene

Aliases for RAB1A Gene

  • RAB1A, Member RAS Oncogene Family 2 3 5
  • YPT1-Related Protein 3 4
  • RAB1 3 4
  • RAB1, Member RAS Oncogene Family 3
  • Rab GTPase YPT1 Homolog (Yeast) 2
  • Ras-Related Protein Rab-1A 3
  • GTP Binding Protein Rab1a 3
  • Rab GTPase YPT1 Homolog 3
  • YPT1 3

External Ids for RAB1A Gene

Previous HGNC Symbols for RAB1A Gene

  • RAB1

Previous GeneCards Identifiers for RAB1A Gene

  • GC02M065447
  • GC02M065271
  • GC02M065289
  • GC02M065288
  • GC02M065225
  • GC02M065167
  • GC02M065297

Summaries for RAB1A Gene

Entrez Gene Summary for RAB1A Gene

  • This gene encodes a member of the Ras superfamily of GTPases. Members of the gene family cycle between inactive GDP-bound and active GTP-bound forms. This small GTPase controls vesicle traffic from the endoplasmic reticulum to the Golgi apparatus. Multiple alternatively spliced transcript variants have been identified for this gene which encode different protein isoforms. [provided by RefSeq, Oct 2008]

GeneCards Summary for RAB1A Gene

RAB1A (RAB1A, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB1A include Hypotrichosis 3 and Rectum Adenocarcinoma. Among its related pathways are Cell Cycle, Mitotic and RAB geranylgeranylation. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB1B.

UniProtKB/Swiss-Prot for RAB1A Gene

  • The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion. Regulates the level of CASR present at the cell membrane. Plays a role in cell adhesion and cell migration, via its role in protein trafficking. Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria. Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport.

Gene Wiki entry for RAB1A Gene

Additional gene information for RAB1A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB1A Gene

Genomics for RAB1A Gene

Regulatory Elements for RAB1A Gene

Enhancers for RAB1A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H065075 1.6 FANTOM5 Ensembl ENCODE dbSUPER 15 +54.2 54160 1 TBP PKNOX1 ATF1 SAP130 TBL1XR1 TAL1 RAD21 TCF12 POLR2A NCOR1 CEP68 RAB1A LOC102724233 ACTR2 SERTAD2 SLC1A4 LOC105374779
GH02H064914 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.4 +213.4 213361 5 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 ZNF766 ZNF143 ZNF207 SLC1A4 LOC102724233 RAB1A RNU6-548P CEP68 ACTR2 RN7SL211P LINC02245
GH02H064851 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.6 +276.6 276583 3 PKNOX1 ATF1 ZNF766 ELK1 ATF7 RUNX3 CAVIN1 REST ZNF592 MEF2D VPS54 RAB1A ACTR2 LINC01800 SLC1A4 AFTPH SERTAD2 GC02P064841
GH02H065055 1.6 Ensembl ENCODE dbSUPER 11.8 +72.9 72874 5 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 CEP68 RAB1A RNU6-548P ACTR2 LOC105374779
GH02H065060 1.5 Ensembl ENCODE dbSUPER 11.8 +66.8 66784 5 HDGF PKNOX1 FOXA2 ATF1 SIN3A FEZF1 TCF12 ZNF121 ZNF766 ZNF143 CEP68 RAB1A RNU6-548P ACTR2 LOC105374779
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RAB1A on UCSC Golden Path with GeneCards custom track

Promoters for RAB1A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000118071 701 2801 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZBTB7B YY1

Genomic Location for RAB1A Gene

Chromosome:
2
Start:
65,070,701 bp from pter
End:
65,130,301 bp from pter
Size:
59,601 bases
Orientation:
Minus strand

Genomic View for RAB1A Gene

Genes around RAB1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB1A Gene

Proteins for RAB1A Gene

  • Protein details for RAB1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62820-RAB1A_HUMAN
    Recommended name:
    Ras-related protein Rab-1A
    Protein Accession:
    P62820
    Secondary Accessions:
    • P11476
    • Q6FIE7
    • Q96N61
    • Q9Y3T2

    Protein attributes for RAB1A Gene

    Size:
    205 amino acids
    Molecular mass:
    22678 Da
    Quaternary structure:
    • May interact with YIPF5. Interacts with C9orf72 (By similarity). Interacts with GDI1; this promotes dissociation from membranes. Interacts with L.pneumophila AnkX, LidA and Lem3. Interacts with L.pneumophila and L.drancourtii LepB; this enhances RAB1A GTPase activity. Interacts with L.pneumophila DrrA; this disrupts the interaction between RAB1A and GDI1 and promotes the exchange of RAB1A-bound GDP with GTP. Interacts with E.coli EspG and S.flexneri VirA; this impairs ER to Golgi trafficking and protein secretion. Identified in a complex composed of RAB1A, ARF6 and E.coli EspG.

    Three dimensional structures from OCA and Proteopedia for RAB1A Gene

    Alternative splice isoforms for RAB1A Gene

neXtProt entry for RAB1A Gene

Post-translational modifications for RAB1A Gene

  • Phosphocholinated at Ser-79 by L.pneumophila AnkX, leading to displace GDP dissociation inhibitors (GDI). Both GDP-bound and GTP-bound forms can be phosphocholinated. Dephosphocholinated by L.pneumophila Lem3, restoring accessibility to L.pneumophila GTPase effector LepB.
  • Phosphorylated by CDK1 kinase during mitosis.
  • Ubiquitination at Lys187
  • Modification sites at PhosphoSitePlus

Other Protein References for RAB1A Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RAB1A (RAB1A)
  • Abcam antibodies for RAB1A

No data available for DME Specific Peptides for RAB1A Gene

Domains & Families for RAB1A Gene

Gene Families for RAB1A Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for RAB1A Gene

Graphical View of Domain Structure for InterPro Entry

P62820

UniProtKB/Swiss-Prot:

RAB1A_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB1A: view

Function for RAB1A Gene

Molecular function for RAB1A Gene

UniProtKB/Swiss-Prot Function:
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion. Regulates the level of CASR present at the cell membrane. Plays a role in cell adhesion and cell migration, via its role in protein trafficking. Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria. Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport.

Phenotypes From GWAS Catalog for RAB1A Gene

Gene Ontology (GO) - Molecular Function for RAB1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003924 GTPase activity IDA,IEA 17684057
GO:0005515 protein binding IPI 15186776
GO:0005525 GTP binding IEA --
GO:0045296 cadherin binding IDA 25468996
genes like me logo Genes that share ontologies with RAB1A: view
genes like me logo Genes that share phenotypes with RAB1A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RAB1A
  • Applied Biological Materials Clones for RAB1A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB1A Gene

Localization for RAB1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB1A Gene

Golgi apparatus. Endoplasmic reticulum. Early endosome. Cytoplasm, cytosol. Membrane. Melanosome. Note=Alternates between membrane-associated and cytosolic forms. {ECO:0000303 PubMed:19942850}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB1A gene
Compartment Confidence
extracellular 5
cytosol 5
golgi apparatus 5
endoplasmic reticulum 4
endosome 4
mitochondrion 2
nucleus 2
plasma membrane 1
cytoskeleton 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Endoplasmic reticulum (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RAB1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS,IBA --
GO:0005737 cytoplasm IEA --
GO:0005768 endosome IEA --
GO:0005769 early endosome IEA --
GO:0005783 endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with RAB1A: view

Pathways & Interactions for RAB1A Gene

genes like me logo Genes that share pathways with RAB1A: view

Pathways by source for RAB1A Gene

1 PharmGKB pathway for RAB1A Gene
1 KEGG pathway for RAB1A Gene
1 Qiagen pathway for RAB1A Gene

Gene Ontology (GO) - Biological Process for RAB1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagosome assembly IMP 22939626
GO:0006810 transport IEA --
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS --
GO:0006897 endocytosis IMP 21303926
genes like me logo Genes that share ontologies with RAB1A: view

No data available for SIGNOR curated interactions for RAB1A Gene

Drugs & Compounds for RAB1A Gene

(1) Drugs for RAB1A Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RAB1A: view

Transcripts for RAB1A Gene

Unigene Clusters for RAB1A Gene

RAB1A, member RAS oncogene family:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RAB1A
  • Applied Biological Materials Clones for RAB1A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for RAB1A Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e
SP1: - - - - -
SP2: - - -
SP3: - - - - - - - -
SP4: - - - - - - -
SP5: - - - -
SP6: - - - - - -
SP7: - - - - - - - - -
SP8: - -
SP9: -

Relevant External Links for RAB1A Gene

GeneLoc Exon Structure for
RAB1A
ECgene alternative splicing isoforms for
RAB1A

Expression for RAB1A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAB1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RAB1A Gene

This gene is overexpressed in Nasal epithelium (7.9), Peripheral blood mononuclear cells (7.7), and Oral epithelium (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RAB1A Gene



Protein tissue co-expression partners for RAB1A Gene

NURSA nuclear receptor signaling pathways regulating expression of RAB1A Gene:

RAB1A

SOURCE GeneReport for Unigene cluster for RAB1A Gene:

Hs.310645

Evidence on tissue expression from TISSUES for RAB1A Gene

  • Nervous system(4.9)
  • Intestine(4.7)
  • Blood(4.3)
  • Liver(4.1)
  • Lung(3.8)
  • Skin(3.1)
  • Pancreas(3)
  • Eye(2.9)
  • Kidney(2.9)
  • Heart(2.6)
  • Lymph node(2.5)
  • Muscle(2.2)
  • Spleen(2.1)
  • Bone marrow(2)
genes like me logo Genes that share expression patterns with RAB1A: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAB1A Gene

Orthologs for RAB1A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RAB1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB1A 33 34
  • 100 (n)
cow
(Bos Taurus)
Mammalia RAB1A 34
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAB1A 34
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAB1A 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAB1A 34 33
  • 97.24 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Rab1 34 33
  • 95.61 (n)
OneToOne
Rab1a 16
rat
(Rattus norvegicus)
Mammalia Rab1a 33
  • 94.31 (n)
chicken
(Gallus gallus)
Aves RAB1A 33 34
  • 91.38 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 79 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia rab1a 33
  • 86.44 (n)
Str.6985 33
African clawed frog
(Xenopus laevis)
Amphibia rab1-prov 33
zebrafish
(Danio rerio)
Actinopterygii rab1a 33 34
  • 82.59 (n)
wufb53a02 33
fruit fly
(Drosophila melanogaster)
Insecta Rab1 35 33 34
  • 71.57 (n)
CG2885 35
  • 46 (a)
Rab-RP3 35
  • 45 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004146 33
  • 68.49 (n)
worm
(Caenorhabditis elegans)
Secernentea rab-1 35 33 34
  • 67.65 (n)
K02E10.1 35
  • 40 (a)
4R79.2 35
  • 38 (a)
C33D12.6 35
  • 36 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D05313g 33
  • 65.51 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR220W 33
  • 63.2 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPT1 33 34
  • 62.71 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons RA-5 33
  • 67.99 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.13077 33
rice
(Oryza sativa)
Liliopsida Os01g0558600 33
  • 70.15 (n)
Os.6802 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10592 34
  • 88 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ypt1 33
  • 65.84 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU08477 33
  • 64.69 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6206 33
Species where no ortholog for RAB1A was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB1A Gene

ENSEMBL:
Gene Tree for RAB1A (if available)
TreeFam:
Gene Tree for RAB1A (if available)

Paralogs for RAB1A Gene

Paralogs for RAB1A Gene

Pseudogenes.org Pseudogenes for RAB1A Gene

genes like me logo Genes that share paralogs with RAB1A: view

Variants for RAB1A Gene

Sequence variations from dbSNP and Humsavar for RAB1A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000058652 -- 65,098,994(+) ACCAC(A/G)CCTGC intron-variant
rs1000095435 -- 65,096,044(+) GCTAC(C/T)CAGGA intron-variant
rs1000140612 -- 65,090,855(+) TGAGA(A/G)TGGAC intron-variant
rs1000149326 -- 65,095,928(+) TCAGG(A/C)AGATC intron-variant
rs1000259310 -- 65,102,026(+) ACAGG(C/T)GTGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB1A Gene

Variant ID Type Subtype PubMed ID
esv1007213 CNV insertion 20482838
esv1784939 CNV insertion 17803354
nsv819395 CNV loss 19587683
nsv834246 CNV loss 17160897

Variation tolerance for RAB1A Gene

Residual Variation Intolerance Score: 51.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.87; 18.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAB1A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAB1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB1A Gene

Disorders for RAB1A Gene

MalaCards: The human disease database

(2) MalaCards diseases for RAB1A Gene - From: DISEASES

Disorder Aliases PubMed IDs
hypotrichosis 3
  • htss2
rectum adenocarcinoma
  • adenocarcinoma of rectum
- elite association - COSMIC cancer census association via MalaCards
Search RAB1A in MalaCards View complete list of genes associated with diseases

Relevant External Links for RAB1A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAB1A
genes like me logo Genes that share disorders with RAB1A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RAB1A Gene

Publications for RAB1A Gene

  1. Structural insights into the dual nucleotide exchange and GDI displacement activity of SidM/DrrA. (PMID: 19942850) Suh HY … Oh BH (The EMBO journal 2010) 3 4 22 60
  2. The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion. (PMID: 2501306) Zahraoui A … Tavitian A (The Journal of biological chemistry 1989) 2 3 4 60
  3. The Legionella pneumophila GTPase activating protein LepB accelerates Rab1 deactivation by a non-canonical hydrolytic mechanism. (PMID: 23821544) Mishra AK … Lambright DG (The Journal of biological chemistry 2013) 3 4 60
  4. Rab1a and Rab5a preferentially bind to binary lipid compositions with higher stored curvature elastic energy. (PMID: 23815289) Kirsten ML … Ces O (Molecular membrane biology 2013) 3 4 60
  5. Structurally distinct bacterial TBC-like GAPs link Arf GTPase to Rab1 inactivation to counteract host defenses. (PMID: 22939626) Dong N … Shao F (Cell 2012) 3 4 60

Products for RAB1A Gene

  • Addgene plasmids for RAB1A

Sources for RAB1A Gene

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