Aliases for RAB1A Gene
External Ids for RAB1A Gene
Previous HGNC Symbols for RAB1A Gene
Previous GeneCards Identifiers for RAB1A Gene
This gene encodes a member of the Ras superfamily of GTPases. Members of the gene family cycle between inactive GDP-bound and active GTP-bound forms. This small GTPase controls vesicle traffic from the endoplasmic reticulum to the Golgi apparatus. Multiple alternatively spliced transcript variants have been identified for this gene which encode different protein isoforms. [provided by RefSeq, Oct 2008]
GeneCards Summary for RAB1A Gene
RAB1A (RAB1A, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Transport to the Golgi and subsequent modification. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB37.
UniProtKB/Swiss-Prot for RAB1A Gene
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion. Regulates the level of CASR present at the cell membrane. Plays a role in cell adhesion and cell migration, via its role in protein trafficking. Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria. Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport.