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Aliases for RAB1A Gene

Aliases for RAB1A Gene

  • RAB1A, Member RAS Oncogene Family 2 3 5
  • YPT1-Related Protein 3 4
  • RAB1 3 4
  • RAB1, Member RAS Oncogene Family 3
  • Rab GTPase YPT1 Homolog (Yeast) 2
  • GTP Binding Protein Rab1a 3
  • Rab GTPase YPT1 Homolog 3
  • YPT1 3

External Ids for RAB1A Gene

Previous HGNC Symbols for RAB1A Gene

  • RAB1

Previous GeneCards Identifiers for RAB1A Gene

  • GC02M065447
  • GC02M065271
  • GC02M065289
  • GC02M065288
  • GC02M065225
  • GC02M065167
  • GC02M065297

Summaries for RAB1A Gene

Entrez Gene Summary for RAB1A Gene

  • This gene encodes a member of the Ras superfamily of GTPases. Members of the gene family cycle between inactive GDP-bound and active GTP-bound forms. This small GTPase controls vesicle traffic from the endoplasmic reticulum to the Golgi apparatus. Multiple alternatively spliced transcript variants have been identified for this gene which encode different protein isoforms. [provided by RefSeq, Oct 2008]

GeneCards Summary for RAB1A Gene

RAB1A (RAB1A, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB1A include legionaire disease. Among its related pathways are Legionellosis and Bisphosphonate Pathway, Pharmacodynamics. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB33A.

UniProtKB/Swiss-Prot for RAB1A Gene

  • The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion. Regulates the level of CASR present at the cell membrane. Plays a role in cell adhesion and cell migration, via its role in protein trafficking. Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria. Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport.

Gene Wiki entry for RAB1A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB1A Gene

Genomics for RAB1A Gene

Regulatory Elements for RAB1A Gene

Enhancers for RAB1A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RAB1A on UCSC Golden Path with GeneCards custom track

Promoters for RAB1A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RAB1A on UCSC Golden Path with GeneCards custom track

Genomic Location for RAB1A Gene

Chromosome:
2
Start:
65,070,701 bp from pter
End:
65,130,301 bp from pter
Size:
59,601 bases
Orientation:
Minus strand

Genomic View for RAB1A Gene

Genes around RAB1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB1A Gene

Proteins for RAB1A Gene

  • Protein details for RAB1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62820-RAB1A_HUMAN
    Recommended name:
    Ras-related protein Rab-1A
    Protein Accession:
    P62820
    Secondary Accessions:
    • P11476
    • Q6FIE7
    • Q96N61
    • Q9Y3T2

    Protein attributes for RAB1A Gene

    Size:
    205 amino acids
    Molecular mass:
    22678 Da
    Quaternary structure:
    • May interact with YIPF5. Interacts with C9orf72 (By similarity). Interacts with GDI1; this promotes dissociation from membranes. Interacts with L.pneumophila AnkX, LidA and Lem3. Interacts with L.pneumophila and L.drancourtii LepB; this enhances RAB1A GTPase activity. Interacts with L.pneumophila DrrA; this disrupts the interaction between RAB1A and GDI1 and promotes the exchange of RAB1A-bound GDP with GTP. Interacts with E.coli EspG and S.flexneri VirA; this impairs ER to Golgi trafficking and protein secretion. Identified in a complex composed of RAB1A, ARF6 and E.coli EspG.

    Three dimensional structures from OCA and Proteopedia for RAB1A Gene

    Alternative splice isoforms for RAB1A Gene

neXtProt entry for RAB1A Gene

Proteomics data for RAB1A Gene at MOPED

Post-translational modifications for RAB1A Gene

  • Phosphocholinated at Ser-79 by L.pneumophila AnkX, leading to displace GDP dissociation inhibitors (GDI). Both GDP-bound and GTP-bound forms can be phosphocholinated. Dephosphocholinated by L.pneumophila Lem3, restoring accessibility to L.pneumophila GTPase effector LepB.
  • Phosphorylated by CDK1 kinase during mitosis.
  • Ubiquitination at Lys 187
  • Modification sites at PhosphoSitePlus

Other Protein References for RAB1A Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RAB1A (RAB1A)

No data available for DME Specific Peptides for RAB1A Gene

Domains & Families for RAB1A Gene

Gene Families for RAB1A Gene

Protein Domains for RAB1A Gene

Graphical View of Domain Structure for InterPro Entry

P62820

UniProtKB/Swiss-Prot:

RAB1A_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB1A: view

Function for RAB1A Gene

Molecular function for RAB1A Gene

UniProtKB/Swiss-Prot Function:
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion. Regulates the level of CASR present at the cell membrane. Plays a role in cell adhesion and cell migration, via its role in protein trafficking. Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria. Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport.
genes like me logo Genes that share phenotypes with RAB1A: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB1A Gene

Localization for RAB1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB1A Gene

Golgi apparatus. Endoplasmic reticulum. Early endosome. Cytoplasm, cytosol. Membrane. Melanosome. Note=Alternates between membrane-associated and cytosolic forms. {ECO:0000303 PubMed:19942850}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB1A Gene COMPARTMENTS Subcellular localization image for RAB1A gene
Compartment Confidence
cytosol 5
extracellular 5
golgi apparatus 5
endoplasmic reticulum 4
endosome 4
lysosome 2
mitochondrion 2
nucleus 2
plasma membrane 2
vacuole 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for RAB1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome IEA --
genes like me logo Genes that share ontologies with RAB1A: view

Pathways & Interactions for RAB1A Gene

genes like me logo Genes that share pathways with RAB1A: view

Pathways by source for RAB1A Gene

1 PharmGKB pathway for RAB1A Gene
1 KEGG pathway for RAB1A Gene
1 Qiagen pathway for RAB1A Gene

Gene Ontology (GO) - Biological Process for RAB1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagosome assembly IMP 22939626
GO:0000278 mitotic cell cycle TAS --
GO:0006886 intracellular protein transport IEA --
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS --
GO:0006897 endocytosis IMP 21303926
genes like me logo Genes that share ontologies with RAB1A: view

No data available for SIGNOR curated interactions for RAB1A Gene

Drugs & Compounds for RAB1A Gene

(1) Drugs for RAB1A Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RAB1A: view

Transcripts for RAB1A Gene

Unigene Clusters for RAB1A Gene

RAB1A, member RAS oncogene family:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAB1A Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e
SP1: - - - - -
SP2: - - -
SP3: - - - - - - - -
SP4: - - - - - - -
SP5: - - - -
SP6: - - - - - -
SP7: - - - - - - - - -
SP8: - -
SP9: -

Relevant External Links for RAB1A Gene

GeneLoc Exon Structure for
RAB1A
ECgene alternative splicing isoforms for
RAB1A

Expression for RAB1A Gene

mRNA expression in normal human tissues for RAB1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RAB1A Gene

This gene is overexpressed in Nasal epithelium (7.9), Peripheral blood mononuclear cells (7.7), and Oral epithelium (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB1A Gene



SOURCE GeneReport for Unigene cluster for RAB1A Gene Hs.310645

genes like me logo Genes that share expression patterns with RAB1A: view

Protein tissue co-expression partners for RAB1A Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RAB1A Gene

Orthologs for RAB1A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RAB1A Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia RAB1A 35
  • 97.24 (n)
  • 100 (a)
RAB1A 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rab1 35
  • 95.61 (n)
  • 100 (a)
Rab1a 16
Rab1 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RAB1A 35
  • 100 (n)
  • 100 (a)
RAB1A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rab1a 35
  • 94.31 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia RAB1A 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAB1A 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAB1A 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAB1A 35
  • 91.38 (n)
  • 99.51 (a)
RAB1A 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 79 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia rab1a 35
  • 86.44 (n)
  • 98.53 (a)
Str.6985 35
African clawed frog
(Xenopus laevis)
Amphibia rab1-prov 35
zebrafish
(Danio rerio)
Actinopterygii rab1a 35
  • 82.59 (n)
  • 96.02 (a)
wufb53a02 35
rab1a 36
  • 96 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG2885 37
  • 46 (a)
Rab-RP3 37
  • 45 (a)
Rab1 37
  • 84 (a)
Rab1 35
  • 71.57 (n)
  • 85.29 (a)
Rab1 36
  • 84 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004146 35
  • 68.49 (n)
  • 81.09 (a)
worm
(Caenorhabditis elegans)
Secernentea 4R79.2 37
  • 38 (a)
C33D12.6 37
  • 36 (a)
K02E10.1 37
  • 40 (a)
rab-1 37
  • 79 (a)
rab-1 35
  • 67.65 (n)
  • 82.76 (a)
rab-1 36
  • 81 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR220W 35
  • 63.2 (n)
  • 73.27 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D05313g 35
  • 65.51 (n)
  • 73.27 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPT1 35
  • 62.71 (n)
  • 72.28 (a)
YPT1 36
  • 70 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons RA-5 35
  • 67.99 (n)
  • 77.11 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.13077 35
rice
(Oryza sativa)
Liliopsida Os.6802 35
Os01g0558600 35
  • 70.15 (n)
  • 77.61 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6206 35
bread mold
(Neurospora crassa)
Ascomycetes NCU08477 35
  • 64.69 (n)
  • 81.68 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ypt1 35
  • 65.84 (n)
  • 80.2 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10592 36
  • 88 (a)
OneToMany
Species with no ortholog for RAB1A:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB1A Gene

ENSEMBL:
Gene Tree for RAB1A (if available)
TreeFam:
Gene Tree for RAB1A (if available)

Paralogs for RAB1A Gene

Pseudogenes.org Pseudogenes for RAB1A Gene

genes like me logo Genes that share paralogs with RAB1A: view

Variants for RAB1A Gene

Sequence variations from dbSNP and Humsavar for RAB1A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1558658 -- 65,115,560(+) AGCAC(A/G)TATTA intron-variant
rs1558659 -- 65,115,566(+) TATTA(C/T)TCCta intron-variant
rs1558660 -- 65,115,569(+) tattc(C/T)tataa intron-variant
rs883927 -- 65,115,079(-) GCCCT(G/T)TGTGC intron-variant
rs1019303 -- 65,115,037(+) catac(C/T)cactt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB1A Gene

Variant ID Type Subtype PubMed ID
nsv834246 CNV Loss 17160897
nsv819395 CNV Loss 19587683
esv271114 CNV Insertion 20981092
esv272265 CNV Insertion 20981092
esv1007213 CNV Insertion 20482838
esv1784939 CNV Insertion 17803354

Variation tolerance for RAB1A Gene

Residual Variation Intolerance Score: 51.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.87; 18.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAB1A Gene

HapMap Linkage Disequilibrium report
RAB1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB1A Gene

Disorders for RAB1A Gene

MalaCards: The human disease database

(1) MalaCards diseases for RAB1A Gene - From: DISEASES

Disorder Aliases PubMed IDs
legionaire disease
  • legionnaires' disease
- elite association - COSMIC cancer census association via MalaCards
Search RAB1A in MalaCards View complete list of genes associated with diseases

Relevant External Links for RAB1A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAB1A
genes like me logo Genes that share disorders with RAB1A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RAB1A Gene

Publications for RAB1A Gene

  1. The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion. (PMID: 2501306) Zahraoui A. … Tavitian A. (J. Biol. Chem. 1989) 2 3 4 67
  2. Structural insights into the dual nucleotide exchange and GDI displacement activity of SidM/DrrA. (PMID: 19942850) Suh H.Y. … Oh B.H. (EMBO J. 2010) 3 23
  3. Rab1 GTPase and dimerization in the cell surface expression of angiotensin II type 2 receptor. (PMID: 19357319) Zhang X. … Wu G. (J. Pharmacol. Exp. Ther. 2009) 3 23
  4. Coordination of golgin tethering and SNARE assembly: GM130 binds syntaxin 5 in a p115-regulated manner. (PMID: 18167358) Diao A. … Lowe M. (J. Biol. Chem. 2008) 3 23
  5. Analysis of GTPase-activating proteins: Rab1 and Rab43 are key Rabs required to maintain a functional Golgi complex in human cells. (PMID: 17684057) Haas A.K. … Barr F.A. (J. Cell Sci. 2007) 3 23

Products for RAB1A Gene

Sources for RAB1A Gene

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