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Aliases for RAB1A Gene

Aliases for RAB1A Gene

  • RAB1A, Member RAS Oncogene Family 2 3
  • YPT1-Related Protein 3 4
  • RAB1 3 4
  • RAB1, Member RAS Oncogene Family 3
  • Rab GTPase YPT1 Homolog (Yeast) 2
  • Ras-Related Protein Rab-1A 3
  • GTP Binding Protein Rab1a 3
  • Rab GTPase YPT1 Homolog 3
  • RAB1, 6
  • YPT1 3

External Ids for RAB1A Gene

Previous Symbols for RAB1A Gene

  • RAB1

Summaries for RAB1A Gene

Entrez Gene Summary for RAB1A Gene

  • This gene encodes a member of the Ras superfamily of GTPases. Members of the gene family cycle between inactive GDP-bound and active GTP-bound forms. This small GTPase controls vesicle traffic from the endoplasmic reticulum to the Golgi apparatus. Multiple alternatively spliced transcript variants have been identified for this gene which encode different protein isoforms. [provided by RefSeq, Oct 2008]

GeneCards Summary for RAB1A Gene

RAB1A (RAB1A, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB1A include rectum adenocarcinoma and choroideremia. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB37.

UniProtKB/Swiss-Prot for RAB1A Gene

  • The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion. Regulates the level of CASR present at the cell membrane. Plays a role in cell adhesion and cell migration, via its role in protein trafficking. Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria. Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport.

Gene Wiki entry for RAB1A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB1A Gene

Genomics for RAB1A Gene

Genomic Location for RAB1A Gene

Start:
65,070,701 bp from pter
End:
65,130,301 bp from pter
Size:
59,601 bases
Orientation:
Minus strand

Genomic View for RAB1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAB1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB1A Gene

Regulatory Elements for RAB1A Gene

Proteins for RAB1A Gene

  • Protein details for RAB1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62820-RAB1A_HUMAN
    Recommended name:
    Ras-related protein Rab-1A
    Protein Accession:
    P62820
    Secondary Accessions:
    • P11476
    • Q6FIE7
    • Q96N61
    • Q9Y3T2

    Protein attributes for RAB1A Gene

    Size:
    205 amino acids
    Molecular mass:
    22678 Da
    Quaternary structure:
    • May interact with YIPF5. Interacts with C9orf72 (By similarity). Interacts with GDI1; this promotes dissociation from membranes. Interacts with L.pneumophila AnkX, LidA and Lem3. Interacts with L.pneumophila and L.drancourtii LepB; this enhances RAB1A GTPase activity. Interacts with L.pneumophila DrrA; this disrupts the interaction between RAB1A and GDI1 and promotes the exchange of RAB1A-bound GDP with GTP. Interacts with E.coli EspG and S.flexneri VirA; this impairs ER to Golgi trafficking and protein secretion. Identified in a complex composed of RAB1A, ARF6 and E.coli EspG.

    Three dimensional structures from OCA and Proteopedia for RAB1A Gene

    Alternative splice isoforms for RAB1A Gene

neXtProt entry for RAB1A Gene

Proteomics data for RAB1A Gene at MOPED

Post-translational modifications for RAB1A Gene

  • Phosphocholinated at Ser-79 by L.pneumophila AnkX, leading to displace GDP dissociation inhibitors (GDI). Both GDP-bound and GTP-bound forms can be phosphocholinated. Dephosphocholinated by L.pneumophila Lem3, restoring accessibility to L.pneumophila GTPase effector LepB
  • Phosphorylated by CDK1 kinase during mitosis.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys24, Lys119, and Lys187

Other Protein References for RAB1A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RAB1A Gene

Domains for RAB1A Gene

Gene Families for RAB1A Gene

HGNC:
  • RAB :RAB, member RAS oncogene

Protein Domains for RAB1A Gene

UniProtKB/Swiss-Prot:

RAB1A_HUMAN
Family:
  • Belongs to the small GTPase superfamily. Rab family.:
    • P62820
genes like me logo Genes that share domains with RAB1A: view

Function for RAB1A Gene

Molecular function for RAB1A Gene

UniProtKB/Swiss-Prot Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion. Regulates the level of CASR present at the cell membrane. Plays a role in cell adhesion and cell migration, via its role in protein trafficking. Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria. Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport.

Gene Ontology (GO) - Molecular Function for RAB1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IDA 17684057
GO:0005515 protein binding IPI 15186776
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RAB1A: view

Phenotypes for RAB1A Gene

genes like me logo Genes that share phenotypes with RAB1A: view

miRNA for RAB1A Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RAB1A Gene

Localization for RAB1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB1A Gene

Golgi apparatus. Endoplasmic reticulum. Early endosome. Cytoplasm, cytosol. Membrane. Melanosome. Note=Alternates between membrane-associated and cytosolic forms.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB1A Gene COMPARTMENTS Subcellular localization image for RAB1A gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
cytosol 3
endosome 2
plasma membrane 2
vacuole 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for RAB1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005737 cytoplasm --
GO:0005768 endosome --
genes like me logo Genes that share ontologies with RAB1A: view

Pathways for RAB1A Gene

genes like me logo Genes that share pathways with RAB1A: view

Pathways by source for RAB1A Gene

1 Qiagen pathway for RAB1A Gene
1 BioSystems pathway for RAB1A Gene
1 PharmGKB pathway for RAB1A Gene
1 KEGG pathway for RAB1A Gene

Gene Ontology (GO) - Biological Process for RAB1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagic vacuole assembly IMP 22939626
GO:0000278 mitotic cell cycle TAS --
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport IBA --
GO:0006888 ER to Golgi vesicle-mediated transport IMP 17684057
genes like me logo Genes that share ontologies with RAB1A: view

Compounds for RAB1A Gene

(1) HMDB Compounds for RAB1A Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with RAB1A: view

Transcripts for RAB1A Gene

Unigene Clusters for RAB1A Gene

RAB1A, member RAS oncogene family:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAB1A Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e
SP1: - - - - -
SP2: - - -
SP3: - - - - - - - -
SP4: - - - - - - -
SP5: - - - -
SP6: - - - - - -
SP7: - - - - - - - - -
SP8: - -
SP9: -

Relevant External Links for RAB1A Gene

GeneLoc Exon Structure for
RAB1A
ECgene alternative splicing isoforms for
RAB1A

Expression for RAB1A Gene

mRNA expression in normal human tissues for RAB1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB1A Gene

SOURCE GeneReport for Unigene cluster for RAB1A Gene Hs.310645

genes like me logo Genes that share expressions with RAB1A: view

Orthologs for RAB1A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RAB1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB1A 36
  • 100 (n)
  • 100 (a)
RAB1A 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RAB1A 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAB1A 36
  • 97.24 (n)
  • 100 (a)
RAB1A 37
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rab1 36
  • 95.61 (n)
  • 100 (a)
Rab1 16
Rab1 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAB1A 37
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAB1A 37
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rab1a 36
  • 94.31 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves RAB1A 36
  • 91.38 (n)
  • 99.51 (a)
RAB1A 37
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 79 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia rab1-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia rab1a 36
  • 86.44 (n)
  • 98.53 (a)
Str.6985 36
zebrafish
(Danio rerio)
Actinopterygii rab1a 36
  • 82.59 (n)
  • 96.02 (a)
rab1a 37
  • 96 (a)
OneToOne
wufb53a02 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004146 36
  • 68.49 (n)
  • 81.09 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rab1 36
  • 71.57 (n)
  • 85.29 (a)
Rab1 37
  • 84 (a)
OneToMany
CG2885 38
  • 46 (a)
Rab1 38
  • 84 (a)
Rab-RP3 38
  • 45 (a)
worm
(Caenorhabditis elegans)
Secernentea rab-1 36
  • 67.65 (n)
  • 82.76 (a)
rab-1 37
  • 81 (a)
OneToMany
4R79.2 38
  • 38 (a)
rab-1 38
  • 79 (a)
C33D12.6 38
  • 36 (a)
K02E10.1 38
  • 40 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR220W 36
  • 63.2 (n)
  • 73.27 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPT1 36
  • 62.71 (n)
  • 72.28 (a)
YPT1 37
  • 70 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D05313g 36
  • 65.51 (n)
  • 73.27 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.13077 36
thale cress
(Arabidopsis thaliana)
eudicotyledons RA-5 36
  • 67.99 (n)
  • 77.11 (a)
rice
(Oryza sativa)
Liliopsida Os.6802 36
Os01g0558600 36
  • 70.15 (n)
  • 77.61 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08477 36
  • 64.69 (n)
  • 81.68 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ypt1 36
  • 65.84 (n)
  • 80.2 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6206 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10592 37
  • 88 (a)
OneToMany
Species with no ortholog for RAB1A:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB1A Gene

ENSEMBL:
Gene Tree for RAB1A (if available)
TreeFam:
Gene Tree for RAB1A (if available)

Paralogs for RAB1A Gene

Paralogs for RAB1A Gene

Pseudogenes.org Pseudogenes for RAB1A Gene

genes like me logo Genes that share paralogs with RAB1A: view

Variants for RAB1A Gene

Sequence variations from dbSNP and Humsavar for RAB1A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs15048 -- 65,088,165(+) ACATC(C/T)AAACA utr-variant-3-prime
rs883927 -- 65,115,079(-) GCCCT(G/T)TGTGC intron-variant
rs883928 -- 65,115,057(-) atggt(A/G)gaagg intron-variant
rs1019303 -- 65,115,037(+) catac(C/T)cactt intron-variant
rs1019304 -- 65,115,203(+) gacaG(A/G)AATGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB1A Gene

Variant ID Type Subtype PubMed ID
nsv834246 CNV Loss 17160897
nsv819395 CNV Loss 19587683
esv271114 CNV Insertion 20981092
esv272265 CNV Insertion 20981092
esv1007213 CNV Insertion 20482838
esv1784939 CNV Insertion 17803354

Relevant External Links for RAB1A Gene

HapMap Linkage Disequilibrium report
RAB1A

Disorders for RAB1A Gene

(3) University of Copenhagen DISEASES for RAB1A Gene

genes like me logo Genes that share disorders with RAB1A: view

No data available for UniProtKB/Swiss-Prot for RAB1A Gene

Publications for RAB1A Gene

  1. The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion. (PMID: 2501306) Zahraoui A. … Tavitian A. (J. Biol. Chem. 1989) 2 3 4
  2. Structural insights into the dual nucleotide exchange and GDI displacement activity of SidM/DrrA. (PMID: 19942850) Suh H.Y. … Oh B.H. (EMBO J. 2010) 4 23
  3. Phosphorylation of two small GTP-binding proteins of the Rab family by p34cdc2. (PMID: 1902553) Bailly E. … Bornens M. (Nature 1991) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Structural mechanism of host Rab1 activation by the bifunctional Legionella type IV effector SidM/DrrA. (PMID: 20176951) Zhu Y. … Shao F. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 4

Products for RAB1A Gene

  • Addgene plasmids for RAB1A

Sources for RAB1A Gene

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