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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RAB1A Gene

protein-coding   GIFtS: 61
GCID: GC02M065297

RAB1A, member RAS oncogene family


(Previous symbol: RAB1)
 Explore 15 diseases affiliated with
RAB1A via our new
 Human Malady Compendium 
Biological research products
for RAB1A
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
RAB1A, Member RAS Oncogene Family1 2     GTP Binding Protein Rab1a2
RAB11 2 3 5     Rab GTPase YPT1 Homolog2
YPT11 2     RAB1, Member RAS Oncogene Family2
YPT1-Related Protein2 3     Ras-Related Protein Rab-1A2

External Ids:    HGNC: 97581   Entrez Gene: 58612   Ensembl: ENSG000001380697   OMIM: 1795085   UniProtKB: P628203   

Export aliases for RAB1A gene to outside databases

Previous GC identifers: GC02M065447 GC02M065271 GC02M065289 GC02M065288 GC02M065225 GC02M065167 GC02M065048


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RAB1A:
This gene encodes a member of the Ras superfamily of GTPases. Members of the gene family cycle between inactive
GDP-bound and active GTP-bound forms. This small GTPase controls vesicle traffic from the endoplasmic reticulum to the
Golgi apparatus. Multiple alternatively spliced transcript variants have been identified for this gene which encode
different protein isoforms. (provided by RefSeq, Oct 2008)

UniProtKB/Swiss-Prot: RAB1A_HUMAN, P62820
Function: Probably required for transit of protein from the ER through Golgi compartment. Binds GTP and GDP and
possesses intrinsic GTPase activity

Gene Wiki entry for RAB1A


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RAB1A gene promoter:
         NF-YA   POU3F2   NF-YB   E2F   CBF-A   CBF-B   E2F-1   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRAB1A promoter sequence
   Search SABiosciences Chromatin IP Primers for RAB1A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p14   Ensembl cytogenetic band:  2p14   HGNC cytogenetic band: 2p14

RAB1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAB1A gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M065297:  view genomic region     (about GC identifiers)

Start:
65,297,835 bp from pter      End:
65,357,435 bp from pter
Size:
59,601 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RAB1A_HUMAN, P62820 (See protein sequence)
Recommended Name: Ras-related protein Rab-1A  
Size: 205 amino acids; 22678 Da
Subunit: May interact with YIPF5 (By similarity)
Subcellular location: Golgi apparatus. Endoplasmic reticulum
6/9 PDB 3D structures from and Proteopedia for RAB1A (see all 9):
2FOL (3D)        2WWX (3D)        3L0I (3D)        3SFV (3D)        3TKL (3D)        4FMB (3D)    
Secondary accessions: P11476 Q6FIE7 Q96N61 Q9Y3T2
Alternative splicing: 3 isoforms:  P62820-1, P11476-1   P62820-2, P11476-2   P62820-3, P11476-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RAB1A: NX_P62820

Post-translational modifications:

  • Phosphorylated by CDK1 kinase during mitosis1
  • Phosphocholinated at Ser-79 by L.pneumophila AnkX, leading to displace GDP dissociation inhibitors (GDI). Both
  • GDP-bound and GTP-bound forms can be phosphocholinated. Dephosphocholinated by L.pneumophila Lem3, restoring
    accessibility to L.pneumophila GTPase effector LepB1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P62820

  • RAB1A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_004152.1  NP_056358.1  

    ENSEMBL proteins: 
     ENSP00000387286   ENSP00000386451   ENSP00000386672   ENSP00000381540   ENSP00000348546  
     ENSP00000260638  
    Reactome Protein details: P62820
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    Uscn Proteins for RAB1A

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IEA--
    GO:0005794Golgi apparatus IEA--


    RAB1A for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    RAB1A for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR003579 Small_GTPase_Rab_type

    Graphical View of Domain Structure for InterPro Entry P62820

    ProtoNet protein and cluster: P62820

    UniProtKB/Swiss-Prot: RAB1A_HUMAN, P62820
    Similarity: Belongs to the small GTPase superfamily. Rab family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: RAB1A_HUMAN, P62820
    Function: Probably required for transit of protein from the ER through Golgi compartment. Binds GTP and GDP and
    possesses intrinsic GTPase activity

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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity TAS2501306
    GO:0005525GTP binding IEA--


    RAB1A for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for RAB1A:
     Decreased G3BP1 protein expres 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1M Phase
    M Phase1.00
    Mitotic M-M/G1 phases0.88
    2Cell Cycle
    Cell Cycle1.00
    Cell Cycle, Mitotic0.84
    3Clearance of Nuclear Envelope Membranes from Chromatin
    Mitotic Prophase0.26
    Golgi Cisternae Pericentriolar Stack Reorganization0.00
    4Bisphosphonate Pathway, Pharmacodynamics
    Bisphosphonate Pathway, Pharmacodynamics1.00
    5PLK1 signaling events
    PLK1 signaling events1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RAB1A
        Epithelial Tight Junctions

    1 BioSystems Pathway for RAB1A 
        PLK1 signaling events

    5/6        Reactome Pathways for RAB1A (see all 6)
        Golgi Cisternae Pericentriolar Stack Reorganization
    Mitotic Prophase
    Cell Cycle
    M Phase
    Mitotic M-M/G1 phases

    1 PharmGKB Pathway for RAB1A
        Bisphosphonate Pathway, Pharmacodynamics


    RAB1A for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAB1A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/101 Interacting proteins for RAB1A (P628202, 3 ENSP000003872864) via UniProtKB, MINT, STRING, and/or I2D (see all 101)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIVEP1P158222, 3, ENSP000003686984MINT-63968 I2D: score=5 STRING: ENSP00000368698
    GDI1P311502, 3, ENSP000003940714MINT-7720823 I2D: score=1 STRING: ENSP00000394071
    CAPNS1P046322, 3MINT-63967 I2D: score=5 
    CREB1P162202, 3MINT-63969 I2D: score=5 
    MAPRE3Q9UPY82, 3MINT-63975 I2D: score=4 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process TAS2501306
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0015031protein transport IEA--
    GO:0016192vesicle-mediated transport IEA--


    RAB1A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for RAB1A

    1 HMDB Compound for RAB1A    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    Search CenterWatch for drugs/clinical trials and news about RAB1A 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for RAB1A gene (2 alternative transcripts): 
    NM_004161.4  NM_015543.1  

    Unigene Cluster for RAB1A:

    RAB1A, member RAS oncogene family
    Hs.310645  [show with all ESTs]
    Unigene Representative Sequence: AK123525
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000494188 ENST00000409784(uc002sdm.3 uc002sdn.3 uc010yqe.2 uc002sdo.3)
    ENST00000409892 ENST00000409751 ENST00000398529 ENST00000356214 ENST00000260638


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    Additional cDNA sequence: 

    AF170935.1 AF498929.1 AK055927.1 AK123525.1 AK303678.1 AK315495.1 AL050268.1 BC000905.2 
    BT019528.1 BT019529.1 BX571747.1 CR533479.1 CR536488.1 M28209.1 

    24/46 DOTS entries (see all 46):

    DT.100880386  DT.100880389  DT.91781406  DT.100880392  DT.100839983  DT.121011761  DT.91781380  DT.100880376 
    DT.100880388  DT.97777879  DT.95259938  DT.425094  DT.121011877  DT.95236109  DT.121011794  DT.100829531 
    DT.121011836  DT.100880377  DT.100646647  DT.121011886  DT.100045112  DT.100880380  DT.40106426  DT.70102915 

    24/787 AceView cDNA sequences (see all 787):

    BM847309 CB119061 BM971301 AI962999 CB158897 CB113929 CD105507 BG388576 
    AW575163 BM999021 BG059991 AA448877 BE673936 BQ788033 NM_004161 BM661969 
    CB128905 BP358052 AA447942 CA429063 CB115968 BU195290 BM783973 AW150848 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for RAB1A (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e
    SP1:                                            -     -                 -     -           -                                             
    SP2:                                                                    -     -           -                                             
    SP3:                                            -     -                 -     -     -     -     -     -                                 
    SP4:                                            -     -           -     -     -     -     -                                             
    SP5:                                            -     -                 -     -                                                         


    ECgene alternative splicing isoforms for RAB1A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RAB1A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CATAAAGTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See RAB1A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RAB1A

    SOURCE GeneReport for Unigene cluster: Hs.310645
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RAB1A gene from 9/35 species (see all 35)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves RAB1A1 RAB1A, member RAS oncogene family 91.38(n)
    99.51(a)
      421273  XM_419342.3  XP_419342.2 
    lizard
    (Anolis carolinensis)
    Reptilia RAB1A6
    --
    --
    97(a)
    78(a)
    1 ↔ 1
    possible ortholog
    1(124468477-124476726)
    GL343635.1(211685-216100)
    African clawed frog
    (Xenopus laevis)
    Amphibia rab1-prov2 RAB1, member RAS oncogene family 87.85(n)    BC045014.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb53a022 Danio rerio cDNA clone MGC55751 IMAGE3816472, complete more 82.74(n)    BC050239.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rab11 , 3 Rho small monomeric GTPase3
    Rab-protein 11
    84(a)
    (best of 3)3
    71.57(n)1
    85.29(a)1
      93D23
    425241  NM_169953.21  NP_732610.11 
    worm
    (Caenorhabditis elegans)
    Secernentea rab-11 , 3 Protein RAB-11 79(a)
    (best of 4)3
    65.53(n)1
    79.51(a)1
      V(1262845-1263838)3
    1786201  NM_070996.31  NP_503397.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YPT1(YFL038C)4
    YPT11
    Rab family GTPase, involved in the ER-to-Golgi step more4
    Ypt1p1
    62.87(n)1
    72.28(a)1
      6(55986-55366)4
    8505051, 4  NP_116615.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons RAB1A1 RAB GTPase-1A 71.67(n)
    81(a)
      834766  NM_124091.4  NP_568678.1 
    rice
    (Oryza sativa)
    Liliopsida Os.68022 Ric1 76.62(n)    NM_193488.1 


    ENSEMBL Gene Tree for RAB1A (if available)
    TreeFam Gene Tree for RAB1A (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RAB1A gene
    RAB102  RAB192  RAB432  RAB182  RAB262  RAB8A2  RAB372  RAB352  
    RAB8B2  RAB1B2  RAB122  RAB302  RAB132  
    18/103 SIMAP similar genes for RAB1A using alignment to 5 protein entries:     RAB1A_HUMAN (see all proteins) (see all similar genes):
    rab1b    DKFZp686J06205    RAB8B    RAB10    RAB1B    RAB1C
    RAB8A    RAB36    RAB15    RAB30    RAB13    RAB6A'
    DKFZp686J07132    RAB43    KRAS    RANP1    RAB5C    NRAS

    RAB1A for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for RAB1A
    PGOHUM00000240462 PGOHUM00000243276


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/863 NCBI SNPs in RAB1A are shown (see all 863    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1446164051,2
    --65313497(+) AACCTA/GTAGTA 3 -- ut31 ds50010--------
    rs781764951,2
    C,F,--65313572(+) TTTATT/GGGCGT 3 -- ds5001 ut311Minor allele frequency- G:0.05WA 118
    rs617588461,2
    C,F,--65313758(-) TTACAC/GAGTAA 3 -- ds5001 ut314Minor allele frequency- G:0.13NA CSA EA 244
    rs1142927911,2
    --65313777(+) TGCACG/AGCATG 3 -- ut31 ds50011Minor allele frequency- A:0.01WA 118
    rs617588471,2
    C,F,--65313795(-) GTCAAG/AATACT 3 -- ut31 ds50011Minor allele frequency- A:0.02NA 120
    rs1389991041,2
    --65314011(+) TTTTAC/TTGTGA 3 -- ut310--------
    rs1815339301,2
    --65314060(+) CATTTC/TACAAT 3 -- ut310--------
    rs1862681501,2
    --65314110(+) CTGTTC/TAGTGA 3 -- ut310--------
    rs1912174661,2
    --65314192(+) GCCCAA/CAACAA 3 -- int1 ut310--------
    rs118840491,2
    C,F,H--65314233(+) CCTGCG/ATGAAG 3 -- ut31 int1 ese31Minor allele frequency- A:0.50NA 4

    HapMap Linkage Disequilibrium report for RAB1A (65297835 - 65357435 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for RAB1A
         1 CNV: 58998

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    RAB1A for disorders           About GeneDecksing

    OMIM gene information: 179508    OMIM disorders: --

    15 diseases for RAB1A:    About MalaCards
    spinal muscular atrophy    rectum adenocarcinoma    muscular atrophy    choroideremia
    legionnaires' disease    herpes simplex    insulin resistance    hepatitis c
    stomatitis    rabies    choroiditis    hepatitis
    adenocarcinoma    malaria    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for RAB1A:
    Choroideremia     Legionnaires' disease

    Export disorders for RAB1A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RAB1A gene, integrated from 9 sources (see all 73):
    (articles sorted by number of sources associating them with RAB1A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion. (PubMed id 2501306)1, 2, 3 Zahraoui A.... Tavitian A. (1989)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    5. Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A. (PubMed id 7991565)1, 2 Farnsworth C.C.... Glomset J.A. (1994)
    6. Phosphorylation of two small GTP-binding proteins of the Rab family by p34cdc2. (PubMed id 1902553)1, 2 Bailly E.... Bornens M. (1991)
    7. Rab1 GTPase and dimerization in the cell surface expression of angiotensin II type 2 receptor. (PubMed id 19357319)1, 9 Zhang X....Wu G. (2009)
    8. Analysis of GTPase-activating proteins: Rab1 and Rab43 are key Rabs required to maintain a functional Golgi complex in human cells. (PubMed id 17684057)1, 9 Haas A.K....Barr F.A. (2007)
    9. Rab1 recruitment of p115 into a cis-SNARE complex: programming budding COPII vesicles for fusion. (PubMed id 10903204)1, 9 Allan B.B....Balch W.E. (2000)
    10. Coordination of golgin tethering and SNARE assembly: GM130 binds syntaxin 5 in a p115-regulated manner. (PubMed id 18167358)1, 9 Diao A....Lowe M. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5861 HGNC: 9758 AceView: RAB1A Ensembl:ENSG00000138069 euGenes: HUgn5861
    ECgene: RAB1A H-InvDB: RAB1A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RAB1A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAB1A Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RAB1A gene:
    Search GeneIP for patents involving RAB1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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