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RAB1A Gene

protein-coding   GIFtS: 62

GC02M065225
RAB1A, member RAS oncogene family
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: RAB1)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
DKFZp564B163 2
RAB1 2, 3, 5
YPT1 1, 2
Descriptions
GTP binding protein Rab1a 2
RAB1, member RAS oncogene family 2
RAB1A, member RAS oncogene family 2
Rab GTPase YPT1 homolog 2
YPT1-related protein 3
External Ids
HGNC: 97581
Entrez Gene: 58612
UniProtKB: P628203
Ensembl: ENSG000001380697
Search outside databases for aliases for RAB1A gene

Previous GC identifers: GC02M065447 GC02M065271 GC02M065289 GC02M065288

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for RAB1A:
This gene encodes a member of the Ras superfamily of GTPases. Members of the gene family cycle
between inactive GDP-bound and active GTP-bound forms. This small GTPase controls vesicle traffic
from the endoplasmic reticulum to the Golgi apparatus. Multiple alternatively spliced transcript
variants have been identified for this gene which encode different protein isoforms. [provided by
RefSeq]

UniProtKB/Swiss-Prot: RAB1A_HUMAN, P62820
Function: Probably required for transit of protein from the ER through Golgi compartment. Binds GTP
and GDP and possesses intrinsic GTPase activity

Gene Wiki entry for RAB1A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the RAB1A gene  

Entrez Gene cytogenetic band: 2p14   Ensembl cytogenetic band:  2p14   HGNC cytogenetic band: 2p14

RAB1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M065225:     (about GC identifiers)

Start:
65,167,493 bp from pter
End:
65,210,793 bp from pter
Size:
43,301 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000002.10  NT_022184.14  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: RAB1A_HUMAN, P62820 (See protein sequence)
Recommended Name: Ras-related protein Rab-1A  
Size: 205 amino acids; 22678 Da
Subunit: May interact with YIPF5 (By similarity)
Subcellular location: Golgi apparatus. Endoplasmic reticulum
PDB structures from and Proteopedia :
2FOL (3D)    
Secondary accessions: P11476 Q96N61 Q9Y3T2
Alternative splicing: 3 isoforms:  P62820-1, P11476-1   P62820-2, P11476-2   P62820-3, P11476-3   

Post-translational modifications:

  • Phosphorylated by CDC2 kinase during mitosis1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_004152.1  NP_056358.1  


    ENSEMBL proteins: 
    ENSP00000260638 ENSP00000381540 ENSP00000348546 ENSP00000345145 ENSP00000386352 ENSP00000387286 
    ENSP00000386451 ENSP00000386672 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Sigma-Aldrich AQUA Peptides for RAB1A  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (Rab1A)
    Human Recombinant Proteins from Abnova (RAB1A)
                  OriGene Purified Recombinant Human Protein: RAB1A 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783 endoplasmic reticulum IEA--
    GO:0005794 Golgi apparatus IEA--
    About this table

    Antibodies for RAB1A: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (Rab1A), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (RAB1A)
    Novus Biologicals Antibody for RAB1A

    Assays for RAB1A: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    4 InterPro domains/families:
     IPR001806 Ras_GTPase
     IPR005225 Small_GTP_bd
     IPR003579 GTPase_Rab
     IPR013753 Ras


       GeneDecks  RAB1A for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P62820

    ProtoNet protein and cluster: P62820

    UniProtKB/Swiss-Prot: RAB1A_HUMAN, P62820
    Similarity: Belongs to the small GTPase superfamily. Rab family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (RAB1A)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_004161

                  Applied Biosystems Silencer® siRNAs for RAB1A

                  Sigma-Aldrich siRNA for RAB1A  
                         Sigma-Aldrich shRNA for RAB1A  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_004161
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_004161
                                     untagged cDNA clones in CMV expression vector (see all 4): AK055927 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: BC000905

    UniProtKB/Swiss-Prot: RAB1A_HUMAN, P62820
    Function: Probably required for transit of protein from the ER through Golgi compartment. Binds GTP
    and GDP and possesses intrinsic GTPase activity

    3 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0003924 GTPase activity TAS2501306
    GO:0005525 GTP binding IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


     Gene Network CentralTM Interacting Genes and Proteins Network for  RAB1A 


    5/49 Interacting proteins for RAB1A (ENSP000002606383 P628202) via UniProtKB, MINT, and/or STRING (see all 49 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RABAC1Q9UI142STRING (score=.944) MINT-68421
    RUSC2Q8N2Y82STRING (score=.984) MINT-61267
    CAPNS1P046322MINT-63967
    CREB1P162202MINT-63969
    HIVEP1P158222MINT-63968
    About this table

    3 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007264 small GTPase mediated signal transduction IEA--
    GO:0015031 protein transport IEA--
    GO:0016192 vesicle-mediated transport TAS2501306
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Enzo Life Sciences drugs & compounds for RAB1A
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for RAB1A

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (RAB1A)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_004161

                  Sigma-Aldrich siRNA for RAB1A  
                         Sigma-Aldrich shRNA for RAB1A  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_004161  NM_015543  

    REFSEQ mRNAs for RAB1A gene (2 alternative transcripts): 

    NM_004161.4   NM_015543.1   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_004161  NM_015543  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_004161
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_004161
                                     untagged cDNA clones in CMV expression vector (see all 4): AK055927 

    Additional cDNA sequence: 

    AF170935.1 AF498929.1 AK055927.1 AK123525.1 AK303678.1 AK315495.1 AL050268.1 BC000905.2 
    BT019528.1 BT019529.1 BX571747.1 CR533479.1 CR536488.1 CR593530.1 CR603642.1 CR606852.1 
    CR616184.1 M28209.1 

    24/47 DOTS entries (see all 47 ):

    DT.100880386  DT.100880389  DT.91781406  DT.100880392  DT.100839983  DT.121011761  DT.91781380  DT.100880376 
    DT.100880388  DT.97777879  DT.425094  DT.95259938  DT.121011877  DT.95236109  DT.121011794  DT.100829531 
    DT.100880377  DT.121011836  DT.432290  DT.100646647  DT.100045112  DT.100880380  DT.121011886  DT.95091730 

    24/787 AceView cDNA sequences (see all 787 ):

    CB119169 N45925 AI056955 AI754132 AI720190 AW136631 AW575163 N75497 
    BP368915 AI804431 AI683808 BM847309 CB119817 BU170821 BM971301 AW473264 
    CB122915 CA942358 AA778332 AI143341 CA773780 AA253286 CR616184 BX571747 

    highest scoring ESTs for RAB1A:

    AL050268 M28209 AA019960 AA021068 AA037057 AA058777 AA063367 AA085190 AA303881 AA307112 

    Unigene Cluster for RAB1A:

    RAB1A, member RAS oncogene family
    Hs.310645  [show with all ESTs]
    Unigene Representative Sequence: AK123525


    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for RAB1A (see all 9 )

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e
    SP1:                                            -     -                 -     -           -                                             
    SP2:                                                                    -     -           -                                             
    SP3:                                            -     -                 -     -     -     -     -     -                                 
    SP4:                                            -     -           -     -     -     -     -                                             
    SP5:                                            -     -                 -     -                                                         

    About this scheme

    ECgene alternative splicing isoforms for RAB1A

    8 Ensembl transcripts including schematic representations:
    ENST00000260638  ENST00000398529  ENST00000356214  ENST00000342609  ENST00000409159  ENST00000409784  
    ENST00000409892  ENST00000409751  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    RAB1A expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for RAB1A

    1 / 2 / 3

    11 probe-sets matching RAB1A gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    34393_r_at2, 3 U95-A 1 1.00 1.00 0.50 1.13 AL050268 1.00 1.00 1.00 1

    34392_s_at2, 3 U95-A 1 1.00 1.00 0.29 1.39 AL050268 1.00 1.00 1.00 1

    1074_at2, 3 U95-A 1 1.00 1.00 0.89 0.92 M28209 1.00 1.00 1.00 1

    32605_r_at2, 3 U95-A 1 0.56 1.00 0.45 0.12 AI768809 0.80 0.80 0.80 1

    69545_at*2, 3 U95-D 1 -- -- 0.63 0.57 H53310 0.20 1.00 0.72 1

    207791_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_004161 0.60 1.00 0.82 1

    208724_s_at2, 3 U133-A 1 1.00 1.00 -- -- BC000905 0.80 1.00 0.91 1

    213440_at2, 3 U133-A 1 1.00 1.00 -- -- AL530264 0.40 0.67 0.55 1

    207791_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    208724_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    213440_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: CATAAAGTTT

    SOURCE GeneReport for Unigene cluster: Hs.310645

    Expression variation in blood from EXPOLDB for RAB1A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for RAB1A gene from 5/21 species (see all 21 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    chimpanzee
    (Pan troglodytes)
    RAB1A1   -- RAB1A, member RAS oncogene family 98.36(n)
    98.03(a)
    459280  XM_530454.2  XP_530454.2 
    cow
    (Bos taurus)
    RAB1A1   -- RAB1A, member RAS oncogene family 98.27(n)
    100(a)
    539339  NM_001033628.1  NP_001028800.1 
    rat
    (Rattus norvegicus)
    Rab11   -- RAB1, member RAS oncogene family 94.31(n)
    100(a)
    81754  NM_031090.2  NP_112352.2 
    mouse
    (Mus musculus)
    Rab11, 5 11 (10.90 cM)5
    RAB1, member RAS oncogene family1, 5 95.61(n)1
    100(a)1
    193241  NM_008996.31  NP_033022.11 
     AB2325835  AF2268735  (see all 30)
    chicken
    (Gallus gallus)
    RAB1A1   -- RAB1A, member RAS oncogene family 91.38(n)
    99.51(a)
    421273  XM_419342.2  XP_419342.2 
    About this table        Species with no ortholog for RAB1A

    ENSEMBL Gene Tree for RAB1A
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for RAB1A gene
    RAB1B2  RAB132  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/305 NCBI SNPs in RAB1A are shown (see all 305 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 92)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 2 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs24224371,2
    A,C,F,H,O65211833(+) AAATAG/TGCAAT 1 -- ng31 tfbs312Minor allele frequency- N:0.00EU EA WA NA 1046
    rs67484621,2
    A,C,F,H65212786(+) ATCTGG/TCCTCC 1 -- ng314Minor allele frequency- T:0.42EU EA WA 406
    rs37320961,2
    A,C,F,H65211587(-) GGAGAA/GGAGAG 1 -- ng31 trp35Minor allele frequency- G:0.27EA EU WA 1900
    rs118842051,2
    C,F65168175(+) AGATGC/GATTTA 2 -- ut31 ese33Minor allele frequency- G:0.03NA 134
    --
    rs76006161,2
    A65168368(+) AGAAAA/GCAAAT 2 -- ut31 ese30--------
    --
    rs22272681,2
    C,F,O65169215(-) GGTCCC/TGGAGC 2 P/P syn1 ese38Minor allele frequency- T:0.22MN NA EA 1884
    rs23026311,2
    A,C,F,H,O65185163(+) AACCAG/TACTTC 1 -- int16Minor allele frequency- T:0.32EA EU WA NA 1988
    rs14201841,2
    A,C,F,H,O65169384(+) TCTTAC/GTGCAT 1 -- int113Minor allele frequency- G:0.36MN EA NA EU WA 2578
    rs97841181,2
    A,C,F,H65179976(+) ctTCTC/TGCAAG 1 -- int18Minor allele frequency- N:0.01EU EA WA NA 628
    rs75928161,2
    A,C,F,H65173512(+) cattcG/Aagtga 1 -- int17Minor allele frequency- A:0.06EU EA WA NA 560
    About this table

    HapMap Linkage Disequilibrium images for RAB1A (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 179508

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/42 PubMed articles for RAB1A gene (see all 42 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 5861 HGNC: 9758 AceView: RAB1A Ensembl:ENSG00000138069 euGenes: HUgn5861
    ECgene: RAB1A H-InvDB: RAB1A
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for RAB1A Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for RAB1A:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Predesigned and custom siRNAs for RAB1A Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Proteins for RAB1A
     Lentivirus-delivered shRNAs for RAB1A Browse small molecules at Sigma-Aldrich
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     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     Search Tocris compounds for RAB1A




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