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Aliases & Descriptions for RAB1A
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases DKFZp564B163 2 RAB1 2 , 3 , 5 YPT1 1 , 2
Descriptions GTP binding protein Rab1a 2 RAB1, member RAS oncogene family 2 RAB1A, member RAS oncogene family 2 Rab GTPase YPT1 homolog 2 YPT1-related protein 3
Search outside databases for aliases for RAB1A genePrevious GC identifers: GC02M065447 GC02M065271 GC02M065289 GC02M065288
Summaries for RAB1A (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for RAB1A : This gene encodes a member of the Ras superfamily of GTPases. Members of the gene family cyclebetween inactive GDP-bound and active GTP-bound forms. This small GTPase controls vesicle trafficfrom the endoplasmic reticulum to the Golgi apparatus. Multiple alternatively spliced transcriptvariants have been identified for this gene which encode different protein isoforms. [provided byRefSeq] UniProtKB/Swiss-Prot: RAB1A_HUMAN, P62820 Function : Probably required for transit of protein from the ER through Golgi compartment. Binds GTPand GDP and possesses intrinsic GTPase activity
Gene Wiki entry for RAB1A
Genomic Location for RAB1A
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the RAB1A gene Entrez Gene cytogenetic band: 2p14 Ensembl cytogenetic band: 2p14 HGNC cytogenetic band: 2p14 RAB1A Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure
GeneLoc location for GC02M065225:
(about GC identifiers )
Start:
65,167,493 bp from pter
End:
65,210,793 bp from pter
Size:
43,301 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000002.10 NT_022184.14 Proteins for RAB1A
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: RAB1A_HUMAN, P62820 (See
protein sequence )Recommended Name: Ras-related protein Rab-1A Size : 205 amino acids; 22678 Da
Subunit : May interact with YIPF5 (By similarity)
Subcellular location : Golgi apparatus. Endoplasmic reticulum
PDB structures from and Proteopedia : 2FOL (3D)
 
Secondary accessions : P11476 Q96N61 Q9Y3T2Alternative splicing : 3 isoforms : P62820-1, P11476-1 P62820-2, P11476-2 P62820-3, P11476-3
Post-translational modifications:
Phosphorylated by CDC2 kinase during mitosis1
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_004152.1 NP_056358.1 ENSEMBL proteins: ENSP00000260638 ENSP00000381540 ENSP00000348546 ENSP00000345145 ENSP00000386352 ENSP00000387286 ENSP00000386451 ENSP00000386672 Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: RAB1A 2 Gene Ontology (GO) cellular component terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0005783 endoplasmic reticulum
IEA -- GO:0005794 Golgi apparatus
IEA --
About this table Antibodies for RAB1A: Assays for RAB1A:
Protein
Domains/ Families for RAB1A(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry P62820 ProtoNet protein and cluster: P62820
UniProtKB/Swiss-Prot: RAB1A_HUMAN, P62820 Similarity : Belongs to the small GTPase superfamily. Rab family
Gene Function for RAB1A
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
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RNAi Products ,
Clones , and
Q-PCR Products
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Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_004161 Applied Biosystems Silencer ® siRNAs for RAB1A Sigma-Aldrich siRNA for RAB1A Sigma-Aldrich shRNA for RAB1A Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_004161                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_004161                                  untagged cDNA clones in CMV expression vector (see all 4 ): AK055927  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: BC000905 UniProtKB/Swiss-Prot: RAB1A_HUMAN, P62820 Function : Probably required for transit of protein from the ER through Golgi compartment. Binds GTPand GDP and possesses intrinsic GTPase activity
3 Gene Ontology (GO) molecular function terms (links to tree view) :
About this table
Pathways & Interactions for RAB1A
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for RAB1A 5/49 Interacting proteins for RAB1A (ENSP00000260638 3 P62820 2 ) via UniProtKB, MINT, and/or STRING (see all 49
)About this table 3 Gene Ontology (GO) biological process terms (links to tree view) :
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Drugs & Compounds for RAB1A (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
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PharmGKB )
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Enzo Life Sciences drugs & compounds for RAB1A
Browse Tocris compounds for RAB1A
Transcripts for RAB1A(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_004161 Sigma-Aldrich siRNA for RAB1A Sigma-Aldrich shRNA for RAB1A Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_004161 NM_015543
REFSEQ mRNAs for RAB1A gene (2 alternative transcripts): NM_004161.4 NM_015543.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_004161 NM_015543
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_004161                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_004161                                  untagged cDNA clones in CMV expression vector (see all 4 ): AK055927  
Additional cDNA sequence: AF170935.1 AF498929.1 AK055927.1 AK123525.1 AK303678.1 AK315495.1 AL050268.1 BC000905.2 BT019528.1 BT019529.1 BX571747.1 CR533479.1 CR536488.1 CR593530.1 CR603642.1 CR606852.1 CR616184.1 M28209.1
24/47 DOTS entries (see all 47
): DT.100880386 DT.100880389 DT.91781406 DT.100880392 DT.100839983 DT.121011761 DT.91781380 DT.100880376 DT.100880388 DT.97777879 DT.425094 DT.95259938 DT.121011877 DT.95236109 DT.121011794 DT.100829531 DT.100880377 DT.121011836 DT.432290 DT.100646647 DT.100045112 DT.100880380 DT.121011886 DT.95091730
24/787 AceView cDNA sequences (see all 787
):CB119169 N45925 AI056955 AI754132 AI720190 AW136631 AW575163 N75497 BP368915 AI804431 AI683808 BM847309 CB119817 BU170821 BM971301 AW473264 CB122915 CA942358 AA778332 AI143341 CA773780 AA253286 CR616184 BX571747
highest scoring ESTs for RAB1A :AL050268 M28209 AA019960 AA021068 AA037057 AA058777 AA063367 AA085190 AA303881 AA307112
Unigene Cluster for RAB1A: RAB1A, member RAS oncogene family Hs.310645 [show with all ESTs ] Unigene Representative Sequence: AK123525 GeneLoc Exon Structure 5/9 Alternative Splicing Database (ASD) splice patterns (SP) for RAB1A (see all 9
) ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e SP1 :               -   -       -   -     -                 SP2 :                       -   -     -                 SP3 :               -   -       -   -   -   -   -   -             SP4 :               -   -     -   -   -   -   -                 SP5 :               -   -       -   -                    
About this scheme ECgene alternative splicing isoforms for RAB1A 8 Ensembl transcripts including schematic representations : ENST00000260638
ENST00000398529
ENST00000356214
ENST00000342609
ENST00000409159
ENST00000409784
ENST00000409892
ENST00000409751
Expression for RAB1A
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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RAB1A expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for RAB1A 1 / 2 / 3
11 probe-sets matching RAB1A gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: CATAAAGTTTSOURCE GeneReport for Unigene cluster: Hs.310645 Expression variation in blood from EXPOLDB for RAB1A
Orthologs for RAB1A
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for RAB1A gene from 5/21 species (see all 21
)
About this table Species with no ortholog for RAB1A ENSEMBL Gene Tree for RAB1A Paralogs for RAB1A (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for RAB1A gene RAB1B 2 RAB13 2
SNPs/Variants for RAB1A (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for RAB1A (up to first 250kb)
Disorders & Mutations for RAB1A
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
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OMIM: 179508
Medical News for RAB1A (Possibly Related Articles in
Doctor's Guide )
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--
Publications for RAB1A (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/42 PubMed articles for RAB1A gene (see all 42
): The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion. (PubMed id 2501306) 2, 3, 4 Zahraoui A.... Tavitian A. (1989) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 3, 4 Ota T....Sugano S. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166) 3, 4 Wiemann S.... Poustka A. (2001) Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A. (PubMed id 7991565) 3, 4 Farnsworth C.C.... Glomset J.A. (1994) Phosphorylation of two small GTP-binding proteins of the Rab family by p34cdc2. (PubMed id 1902553) 3, 4 Bailly E.... Bornens M. (1991) Analysis of GTPase-activating proteins: Rab1 and Rab43 are key Rabs required to maintain a functional Golgi complex in human cells. (PubMed id 17684057) 1, 3 Haas A.K....Barr F.A. (2007) Rab1 recruitment of p115 into a cis-SNARE complex: programming budding COPII vesicles for fusion. (PubMed id 10903204) 1, 3 Allan B.B....Balch W.E. (2000) Coordination of golgin tethering and SNARE assembly: GM130 binds syntaxin 5 in a p115-regulated manner. (PubMed id 18167358) 1, 3 Diao A....Lowe M. (2008) TBC1D20 is a Rab1 GTPase-activating protein that mediates hepatitis C virus replication. (PubMed id 17901050) 3 Sklan E.H....Glenn J.S. (2007)
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Genome Databases showing RAB1A
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miRBase ,
ECgene ,
and/or
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Specialized Databases showing RAB1A (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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