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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RAB19 Gene

protein-coding   GIFtS: 40
GCID: GC07P140103

RAB19, Member RAS Oncogene Family

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
RAB19, Member RAS Oncogene Family1 2
RAB19B2 3
GTP-Binding Protein RAB19B2
Ras-Related Protein Rab-192

External Ids:    HGNC: 199821   Entrez Gene: 4014092   Ensembl: ENSG000001469557   UniProtKB: A4D1S53   

Export aliases for RAB19 gene to outside databases

Previous GC identifers: GC07P139754 GC07P134397


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RAB19 Gene: 
RAB19 (RAB19, member RAS oncogene family) is a protein-coding gene. Diseases associated with RAB19 include pilocytic astrocytoma, and astrocytoma. GO annotations related to this gene include GTP binding. An important paralog of this gene is RAB39A.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007914.15  NC_018918.2  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RAB19 gene promoter:
         USF1   Elk-1   AML1a   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   Nkx5-1   USF-1   Sox9   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRAB19 promoter sequence
   Search SABiosciences Chromatin IP Primers for RAB19

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB19


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q34   Ensembl cytogenetic band:  7q34   HGNC cytogenetic band: 7q34

RAB19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAB19 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P140103:  view genomic region     (about GC identifiers)

Start:
140,103,843 bp from pter      End:
140,126,050 bp from pter
Size:
22,208 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 139,432,676-139,454,883     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RAB19_HUMAN, A4D1S5 (See protein sequence)
Recommended Name: Ras-related protein Rab-19  
Size: 217 amino acids; 24400 Da
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
Secondary accessions: A4D1S6 B2RTS6 B5MDR2 Q9UL27
Alternative splicing: 2 isoforms:  A4D1S5-1   A4D1S5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RAB19: NX_A4D1S5

Explore proteomics data for RAB19 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_A4D1S5

  • RAB19 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RAB19 Protein Expression
    REFSEQ proteins: NP_001008749.2  
    ENSEMBL proteins: 
     ENSP00000420782   ENSP00000348778   ENSP00000275874   ENSP00000440167  

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    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----

    RAB19 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR003579 Small_GTPase_Rab_type
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry A4D1S5

    ProtoNet protein and cluster: A4D1S5

    UniProtKB/Swiss-Prot: RAB19_HUMAN, A4D1S5
    Similarity: Belongs to the small GTPase superfamily. Rab family


    RAB19 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity ----
    GO:0005525GTP binding IEA--
         
    RAB19 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RAB19

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/33 Interacting proteins for RAB19 (ENSP000002758744) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RANBP1ENSP000003275834STRING: ENSP00000327583
    RANBP2ENSP000002831954STRING: ENSP00000283195
    RANGAP1ENSP000003485774STRING: ENSP00000348577
    ARHGDIAENSP000002693214STRING: ENSP00000269321
    KPNB1ENSP000002901584STRING: ENSP00000290158
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process ----
    GO:0006886intracellular protein transport ----
    GO:0006913nucleocytoplasmic transport ----
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction IEA--

    RAB19 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RAB19

    Search CenterWatch for drugs/clinical trials and news about RAB19

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RAB19 gene: 
    NM_001008749.2  

    Unigene Cluster for RAB19:

    RAB19, member RAS oncogene family
    Hs.583545  [show with all ESTs]
    Unigene Representative Sequence: NM_001008749
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000495590 ENST00000356407(uc011krc.1) ENST00000275874 ENST00000537763(uc010lni.2)

    miRNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAB19

    Additional mRNA sequence: 

    AF091033.1 BC140796.1 BC171745.1 

    2 DOTS entries:

    DT.91711172  DT.121036849 

    1 AceView cDNA sequence:

    AF091033 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RAB19 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCAAGGAGC
    RAB19 Expression
    About this image


    See RAB19 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.583545
        SABiosciences Custom PCR Arrays for RAB19
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB19

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RAB19 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rab191 , 5 RAB19, member RAS oncogene family1, 5 86.33(n)1
    88.94(a)1
      6 (18.16 cM)5
    193311  NM_011226.11  NP_035356.11 
     393811755 
    chicken
    (Gallus gallus)
    Aves RAB191 RAB19, member RAS oncogene family 74.92(n)
    79.91(a)
      418113  XM_416347.3  XP_416347.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5556451 ras-related protein Rab-19-like 65.57(n)
    65.26(a)
      555645  XM_678213.4  XP_683305.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rab-RP36
    Rab-related protein 3
    46(a)
    1 → many
    3L(8290118-8291606)
    worm
    (Caenorhabditis elegans)
    Secernentea rab-196
    Protein RAB-19
    44(a)
    1 → many
    IV(13382055-13384316)


    ENSEMBL Gene Tree for RAB19 (if available)
    TreeFam Gene Tree for RAB19 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RAB19 gene
    RAB39A2  RAB2A2  RAB252  RAB432  RAB142  RAB4B2  RAB39B2  RAB11B2  
    RAB11A2  RAB422  RAB4A2  RAB302  RAB4B-EGLN22  RAB2B2  
    18/90 SIMAP similar genes for RAB19 using alignment to 2 protein entries:     RAB19_HUMAN (see all proteins) (see all similar genes):
    RAB43    DKFZp686J07132    RAB30    DKFZp686J06205    RAB8B    rab1b
    RAB11A    RAB8A    RAB10    RAB11B    RAB13    RAB2A
    RAB2B    RAB15    RAB39B    RAB26    DKFZp313C1541    RAB12

    RAB19 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/639 SNPs in RAB19 are shown (see all 639)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2003055251,2
    C--140101844(+) AAAAA-/ATGAAA 1 -- us2k10--------
    rs1880562501,2
    --140101864(+) AATAGC/TTGGGC 1 -- us2k10--------
    rs1900734181,2
    --140101886(+) CACCTA/GTAGTC 1 -- us2k10--------
    rs2010484411,2
    --140102018(+) AAACA-/TTTTTT 1 -- us2k10--------
    rs1451282291,2
    --140102019(+) AAACA-/TTTTTT 1 -- us2k10--------
    rs1826470821,2
    --140102065(+) CTGACC/GCAAAC 1 -- us2k10--------
    rs77911881,2
    C--140102148(+) AAATGA/CTGGTT 1 -- us2k10--------
    rs592114701,2
    C,F--140102167(+) CAAAGG/CTTGAT 1 -- us2k11Minor allele frequency- C:0.50WA 2
    rs731632461,2
    C,F--140102216(+) AACAGG/AACACC 1 -- us2k15Minor allele frequency- A:0.26NA CSA WA EA 362
    rs132357191,2
    C,F--140102340(+) CTGTGA/GTAGAC 1 -- us2k110Minor allele frequency- G:0.48NA WA CSA EA 372

    HapMap Linkage Disequilibrium report for RAB19 (140103843 - 140126050 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RAB19:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2735212CNV Deletion23290073
    nsv522190CNV Gain19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for RAB19:    About MalaCards
    pilocytic astrocytoma    astrocytoma


    RAB19 for disorders           About GeneDecksing


    Export disorders for RAB19 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RAB19 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with RAB19)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    3. The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (2003)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 401409 HGNC: 19982 AceView: RAB19B Ensembl:ENSG00000146955 euGenes: HUgn401409
    ECgene: RAB19 H-InvDB: RAB19

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RAB19 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RAB19 gene:
    Search GeneIP for patents involving RAB19

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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