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Aliases for RAB19 Gene

Aliases for RAB19 Gene

  • RAB19, Member RAS Oncogene Family 2 3 5
  • RAB19B 3 4
  • GTP-Binding Protein RAB19B 3
  • Ras-Related Protein Rab-19 3

External Ids for RAB19 Gene

Previous GeneCards Identifiers for RAB19 Gene

  • GC07P139754
  • GC07P140103
  • GC07P134397

Summaries for RAB19 Gene

GeneCards Summary for RAB19 Gene

RAB19 (RAB19, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are RAB geranylgeranylation and Metabolism of proteins. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB43.

Additional gene information for RAB19 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB19 Gene

Genomics for RAB19 Gene

Regulatory Elements for RAB19 Gene

Enhancers for RAB19 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H140229 2 FANTOM5 Ensembl ENCODE dbSUPER 1.4 -172.0 -171986 5.7 PKNOX1 FOXA2 MLX ZFP64 ARID4B FEZF1 DMAP1 SLC30A9 SP3 SP5 KDM7A RNU6-797P JHDM1D-AS1 TBXAS1 RAB19 GC07P140221 RNU1-58P
GH07H140403 0.8 ENCODE 0.7 +0.5 457 1.2 PKNOX1 SIN3A ETS1 E2F1 ZNF366 POLR2A SCRT2 ZNF143 ZNF600 PRDM10 SLC37A3 RAB19
GH07H140397 1.1 ENCODE 0.4 -5.6 -5607 1.8 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF143 SP3 MXD4 REST KAT8 SLC37A3 RAB19 RNA5SP248
GH07H140396 1 ENCODE 0.4 -7.2 -7207 0.2 PKNOX1 FEZF1 BRCA1 ZNF2 KLF7 YY2 TSHZ1 ZNF623 ZNF518A ZNF610 CCT4P1 RNU4-74P RAB19 RNA5SP248
GH07H140389 1 Ensembl ENCODE 0.4 -13.2 -13222 1.6 RB1 MAX EBF1 ZFHX2 POLR2A EED SCRT2 ADNP RUNX3 IKZF2 TBXAS1 SLC37A3 RNA5SP248 RAB19
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RAB19 on UCSC Golden Path with GeneCards custom track

Promoters for RAB19 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000219078 278 601 SIN3A ETS1 E2F1 POLR2A SCRT2 ZNF143 PRDM10 EZH2 THAP11 SCRT1

Genomic Locations for RAB19 Gene

Genomic Locations for RAB19 Gene
23,057 bases
Plus strand

Genomic View for RAB19 Gene

Genes around RAB19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB19 Gene

Proteins for RAB19 Gene

  • Protein details for RAB19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras-related protein Rab-19
    Protein Accession:
    Secondary Accessions:
    • A4D1S6
    • B2RTS6
    • B5MDR2
    • Q9UL27

    Protein attributes for RAB19 Gene

    217 amino acids
    Molecular mass:
    24400 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RAB19 Gene


neXtProt entry for RAB19 Gene

Post-translational modifications for RAB19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB19 Gene

No data available for DME Specific Peptides for RAB19 Gene

Domains & Families for RAB19 Gene

Gene Families for RAB19 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RAB19 Gene

Suggested Antigen Peptide Sequences for RAB19 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Rab family.
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB19: view

Function for RAB19 Gene

Phenotypes From GWAS Catalog for RAB19 Gene

Gene Ontology (GO) - Molecular Function for RAB19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RAB19: view
genes like me logo Genes that share phenotypes with RAB19: view

Animal Models for RAB19 Gene

MGI Knock Outs for RAB19:

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RAB19 Gene

Localization for RAB19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB19 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB19 gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytosol 3
golgi apparatus 3
endosome 3
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for RAB19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IBA --
GO:0005794 Golgi apparatus IBA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with RAB19: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RAB19 Gene

Pathways & Interactions for RAB19 Gene

genes like me logo Genes that share pathways with RAB19: view

Pathways by source for RAB19 Gene

Interacting Proteins for RAB19 Gene

Gene Ontology (GO) - Biological Process for RAB19 Gene


No data available for SIGNOR curated interactions for RAB19 Gene

Drugs & Compounds for RAB19 Gene

No Compound Related Data Available

Transcripts for RAB19 Gene

mRNA/cDNA for RAB19 Gene

(5) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RAB19 Gene

RAB19, member RAS oncogene family:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB19 Gene

No ASD Table

Relevant External Links for RAB19 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RAB19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAB19 Gene

mRNA differential expression in normal tissues according to GTEx for RAB19 Gene

This gene is overexpressed in Whole Blood (x8.2), Pancreas (x7.9), Colon - Transverse (x6.9), Pituitary (x6.4), and Kidney - Cortex (x5.4).

Protein differential expression in normal tissues from HIPED for RAB19 Gene

This gene is overexpressed in Cerebrospinal fluid (15.4), Platelet (11.6), and Monocytes (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RAB19 Gene

NURSA nuclear receptor signaling pathways regulating expression of RAB19 Gene:


SOURCE GeneReport for Unigene cluster for RAB19 Gene:

genes like me logo Genes that share expression patterns with RAB19: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAB19 Gene

Orthologs for RAB19 Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB19 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RAB19 33 34
  • 99.54 (n)
(Canis familiaris)
Mammalia RAB19 34 33
  • 87.1 (n)
(Mus musculus)
Mammalia Rab19 33 16 34
  • 86.33 (n)
(Bos Taurus)
Mammalia RAB19 33 34
  • 86.18 (n)
(Rattus norvegicus)
Mammalia Rab19 33
  • 86.02 (n)
(Monodelphis domestica)
Mammalia RAB19 34
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia RAB19 34
  • 82 (a)
(Gallus gallus)
Aves RAB19 33 34
  • 74.92 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia rab19 33
  • 72.36 (n)
(Danio rerio)
Actinopterygii LOC555645 33
  • 65.57 (n)
RAB19 34
  • 63 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rab-RP3 34
  • 47 (a)
(Caenorhabditis elegans)
Secernentea rab-19 34
  • 46 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 46 (a)
Species where no ortholog for RAB19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB19 Gene

Gene Tree for RAB19 (if available)
Gene Tree for RAB19 (if available)

Paralogs for RAB19 Gene

Paralogs for RAB19 Gene

genes like me logo Genes that share paralogs with RAB19: view

Variants for RAB19 Gene

Sequence variations from dbSNP and Humsavar for RAB19 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000182796 -- 140,419,430(+) AGTTT(C/T)TTTCC intron-variant
rs1000263715 -- 140,418,737(+) GCCTG(G/T)AGTCC intron-variant
rs1000401217 -- 140,418,524(+) TGAGC(C/T)GAGAT intron-variant
rs1000423119 -- 140,425,031(+) TTACA(A/G)TCCCA intron-variant
rs1000612474 -- 140,415,105(+) GGTCT(C/T)GCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB19 Gene

Variant ID Type Subtype PubMed ID
nsv608500 CNV loss 21841781
nsv522190 CNV gain 19592680
nsv1132090 CNV deletion 24896259
nsv1022919 CNV gain 25217958
esv3615232 CNV loss 21293372
esv3542518 CNV deletion 23714750
esv2762706 CNV loss 21179565
esv2735212 CNV deletion 23290073

Variation tolerance for RAB19 Gene

Residual Variation Intolerance Score: 87.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.21; 62.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAB19 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB19 Gene

Disorders for RAB19 Gene

Relevant External Links for RAB19

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RAB19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB19 Gene

Publications for RAB19 Gene

  1. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 60
  2. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PMID: 19056867) Gonzales PA … Knepper MA (Journal of the American Society of Nephrology : JASN 2009) 3 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 4 60
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for RAB19 Gene

Sources for RAB19 Gene

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