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RAB19 Gene

protein-coding   GIFtS: 38

GC07P139754
RAB19, member RAS oncogene family
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for RAB19

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
RAB19B 1, 2, 3
Descriptions
GTP-binding protein RAB19B 2
RAB19, member RAS oncogene family 2
External Ids
HGNC: 199821
Entrez Gene: 4014092
UniProtKB: A4D1S53
Ensembl: ENSG000001469557
Search outside databases for aliases for RAB19 gene

Summaries
for RAB19

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

   --

Genomic Location
for RAB19

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q34   Ensembl cytogenetic band:  7q34   HGNC cytogenetic band: 7q34

RAB19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P139754:     (about GC identifiers)

Start:
 139,753,916 bp from pter
End:
 139,772,419 bp from pter
Size:
 18,504 bases
Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 139,436,284-139,454,783     
RefSeq DNA sequence:
NC_000007.12  NT_007914.14  NT_079596.2  

Proteins
for RAB19

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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 UniProtKB/Swiss-Prot: RAB19_HUMAN, A4D1S5 (See protein sequence)
Recommended Name: Ras-related protein Rab-19  
Size: 217 amino acids; 24400 Da
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
Secondary accessions: A4D1S6 B2RTS6 B5MDR2 Q9UL27
Alternative splicing: 2 isoforms:  A4D1S5-1   A4D1S5-2   

REFSEQ proteins: NP_001008749.1  

ENSEMBL proteins: 
ENSP00000275874 ENSP00000348778 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (RAB19B)
Human Recombinant Proteins from Abnova (RAB19B)
              OriGene Purified Recombinant Human Protein: RAB19 

1 Gene Ontology (GO) cellular component term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005886 plasma membrane IEA--
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Antibodies for RAB19: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for RAB19
Browse R&D Systems for Antibodies
Antibodies from Abcam (RAB19B), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (RAB19B)
Novus Biologicals Antibodies for RAB19

Assays for RAB19: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for RAB19

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
3 InterPro domains/families:
 IPR001806 Ras_GTPase
 IPR005225 Small_GTP_bd
 IPR013753 Ras


   GeneDecks  RAB19 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry A4D1S5

ProtoNet protein and cluster: A4D1S5

UniProtKB/Swiss-Prot: RAB19_HUMAN, A4D1S5
Similarity: Belongs to the small GTPase superfamily. Rab family

Gene Function
for RAB19

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (RAB19)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (RAB19B)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001008749

              Applied Biosystems Silencer® siRNAs for RAB19

              Sigma-Aldrich siRNA for RAB19  
                     Sigma-Aldrich shRNA for RAB19  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001008749
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001008749
                                 untagged cDNA clone in CMV expression vector: NM_001008749 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_001008749

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0000166 nucleotide binding IEA--
GO:0005525 GTP binding IEA--
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Pathways & Interactions
for RAB19

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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  --

1 Gene Ontology (GO) biological process term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA--
About this table

Drugs & Compounds
for RAB19

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for RAB19

Transcripts
for RAB19

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (RAB19)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (RAB19B)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001008749

              Sigma-Aldrich siRNA for RAB19  
                     Sigma-Aldrich shRNA for RAB19  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001008749  

REFSEQ mRNAs for RAB19 gene: 

NM_001008749.1   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001008749  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001008749
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001008749
                                 untagged cDNA clone in CMV expression vector: NM_001008749 

Additional cDNA sequence: 

AF091033.1 BC140796.1 BC171745.1 

2 DOTS entries:

DT.91711172  DT.121036849 

1 AceView cDNA sequence:

AF091033 

Unigene Cluster for RAB19:

RAB19, member RAS oncogene family
Hs.583545  [show with all ESTs]
Unigene Representative Sequence: BC140796


GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:
ENST00000275874  ENST00000356407  

Expression
for RAB19

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

RAB19 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for RAB19

1Data from GNF BioGPS
    About these images

About these images

CGAP SAGE TAG: GCCAAGGAGC

SOURCE GeneReport for Unigene cluster: Hs.583545

Orthologs
for RAB19

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for RAB19 gene from 5/7 species (see all 7 )
Organism Gene Locus Description Human
Similarity		 NCBI accessions
dog
(Canis familiaris)		 RAB191   -- RAB19, member RAS oncogene family 87.1(n)
89.4(a)		 482767  XM_539883.1  XP_539883.1 
chimpanzee
(Pan troglodytes)		 RAB191   -- RAB19, member RAS oncogene family 99.49(n)
99.62(a)		 463777  XM_519423.2  XP_519423.2 
cow
(Bos taurus)		 RAB191   -- RAB19, member RAS oncogene family 86.18(n)
88.02(a)		 506911  NM_001035040.1  NP_001030212.1 
rat
(Rattus norvegicus)		 Rab191   -- RAB19, member RAS oncogene family 86.02(n)
90.32(a)		 500088  NM_001024326.1  NP_001019497.1 
mouse
(Mus musculus)		 Rab191, 5 65
 RAB19, member RAS oncogene family1, 5 86.33(n)1
88.94(a)1		 193311  NM_011226.11  NP_035356.11 
 AB2326135  AK0175905  (see all 9)
About this table        Species with no ortholog for RAB19

ENSEMBL Gene Tree for RAB19

Paralogs
for RAB19

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for RAB19 gene
RAB432  ENSG000001850512  RAB302  

SNPs/Variants
for RAB19

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/186 NCBI SNPs in RAB19 are shown (see all 186 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 32)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 7 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
rs29483861,2
A,C,F,H,O139772219(+) AGAAGT/CACGGC 1 H/Y mis1 ese38Minor allele frequency- C:0.24EU EA WA 834
rs132379491,2
C,F,H139752973(+) AATATA/GCCATA 1 -- ng51 tfbs34Minor allele frequency- G:0.43EU EA WA 414
--
rs47267881,2
A,C139753407(+) ccttgA/Gccttc 1 -- ng510--------
--
rs96402271,2
A,C139753223(+) gatctC/Tggatc 1 -- ng510--------
--
rs39241821,2
C139753605(-) GGAGAC/TGAGGT 1 -- ng510--------
--
rs47267861,2
C139753265(+) ttctcC/Tggcct 1 -- ng510--------
--
rs69464651,2
C139753449(+) gtgcaC/TggccT 1 -- ng510--------
--
rs47267871,2
A139753355(+) ctccaC/Tgttgg 1 -- ng510--------
rs47268071,2
A,C,F,H139772308(+) ATCGCG/ACGCAA 1 A/A syn18Minor allele frequency- A:0.12EU EA WA 834
rs29716891,2
A,F,H139757250(-) CTGGCC/GGAACT 1 S/S syn1 ese34Minor allele frequency- G:0.06EU EA WA 418
About this table

HapMap Linkage Disequilibrium images for RAB19 (up to first 250kb)

Disorders & Mutations
for RAB19

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

   --

Medical News
for RAB19

(Possibly Related Articles in Doctor's Guide)
About This Section

   --

Publications
for RAB19

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

4 PubMed articles for RAB19 gene:

Search for RAB19

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing RAB19

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section
Entrez Gene: 401409 HGNC: 19982 AceView: RAB19B Ensembl:ENSG00000146955 euGenes: HUgn401409
ECgene: RAB19 H-InvDB: RAB19

Other Databases showing RAB19

(According to HUGE)
About This Section

   --

Specialized Databases showing RAB19

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

   --

Licensable Technologies
for RAB19

(Available from WIS Yeda, Salk, Tufts)
About This Section

  --

Services
for RAB19

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for RAB19:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for RAB19-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for RAB19 Antibodies for RAB19
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for RAB19 Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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 Recombinant & Natural Proteins  

 Recombinant Proteins (RAB19B)
 Antibodies (RAB19B)
 Chimera RNAi (RAB19B)
 Custom Service for Mouse Mab
 Custom Service for Rabbit Pab from Full-length Protein
  
 Search for Antibodies & Assays

 Recombinant Proteins
(RAB19B)
 Antibodies (RAB19B)
 Tagged/untagged cDNA clones
 Validated SYBR primer pairs
 Purified proteins from HEK293T cells
 Western blot validated antibodies
 shRNA in GFP-retroviral vector
 Search Tocris compounds for RAB19




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for RAB19

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