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Aliases for RAB19 Gene

Aliases for RAB19 Gene

  • RAB19, Member RAS Oncogene Family 2 3 5
  • RAB19B 3 4
  • GTP-Binding Protein RAB19B 3
  • Ras-Related Protein Rab-19 3

External Ids for RAB19 Gene

Previous GeneCards Identifiers for RAB19 Gene

  • GC07P139754
  • GC07P140103
  • GC07P134397

Summaries for RAB19 Gene

GeneCards Summary for RAB19 Gene

RAB19 (RAB19, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Metabolism of proteins. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB43.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB19 Gene

Genomics for RAB19 Gene

Regulatory Elements for RAB19 Gene

Enhancers for RAB19 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F140229 1.3 FANTOM5 Ensembl ENCODE 1.4 -172.0 -171986 5.7 PKNOX1 MLX ZFP64 ARID4B FEZF1 DMAP1 SLC30A9 FOS SP3 SP5 KDM7A RNU6-797P JHDM1D-AS1 TBXAS1 RAB19 GC07P140221 RNU1-58P
GH07F140403 0.2 ENCODE 0.8 +0.5 457 1.2 ETS1 E2F1 ZNF316 POLR2A ZNF366 SCRT2 ZNF143 PRDM10 ZNF600 THAP11 SLC37A3 RAB19
GH07F140396 0.4 ENCODE 0.4 -7.2 -7207 0.2 PKNOX1 SIN3A FEZF1 BRCA1 ZNF2 KLF7 ZNF263 YY2 TSHZ1 ZNF518A RNU4-74P CCT4P1 RNA5SP248 RAB19
GH07F140397 0.2 ENCODE 0.4 -5.6 -5607 1.8 PKNOX1 CREB3L1 SIN3A ARID4B DMAP1 ZNF143 KLF13 SP3 MXD4 REST SLC37A3 RAB19 RNA5SP248
GH07F140388 0.5 Ensembl ENCODE 0.4 -13.3 -13322 3.4 HDAC1 CBX3 ARNT CBX5 GATA2 SCRT2 SIRT6 CREM EGR2 ZBTB2 SLC37A3 RNA5SP248 RAB19
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RAB19 on UCSC Golden Path with GeneCards custom track

Promoters for RAB19 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000314132 278 1001 ETS1 E2F1 ZNF316 POLR2A ZNF366 SCRT2 ZNF143 PRDM10 ZNF600 THAP11

Genomic Location for RAB19 Gene

Chromosome:
7
Start:
140,403,822 bp from pter
End:
140,426,878 bp from pter
Size:
23,057 bases
Orientation:
Plus strand

Genomic View for RAB19 Gene

Genes around RAB19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB19 Gene

Proteins for RAB19 Gene

  • Protein details for RAB19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A4D1S5-RAB19_HUMAN
    Recommended name:
    Ras-related protein Rab-19
    Protein Accession:
    A4D1S5
    Secondary Accessions:
    • A4D1S6
    • B2RTS6
    • B5MDR2
    • Q9UL27

    Protein attributes for RAB19 Gene

    Size:
    217 amino acids
    Molecular mass:
    24400 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RAB19 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAB19 Gene

Post-translational modifications for RAB19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB19 Gene

No data available for DME Specific Peptides for RAB19 Gene

Domains & Families for RAB19 Gene

Gene Families for RAB19 Gene

Protein Domains for RAB19 Gene

Suggested Antigen Peptide Sequences for RAB19 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A4D1S5

UniProtKB/Swiss-Prot:

RAB19_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB19: view

Function for RAB19 Gene

Gene Ontology (GO) - Molecular Function for RAB19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RAB19: view
genes like me logo Genes that share phenotypes with RAB19: view

Animal Models for RAB19 Gene

MGI Knock Outs for RAB19:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RAB19 Gene

Localization for RAB19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB19 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB19 Gene COMPARTMENTS Subcellular localization image for RAB19 gene
Compartment Confidence
extracellular 5
cytosol 3
plasma membrane 3
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for RAB19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with RAB19: view

Pathways & Interactions for RAB19 Gene

genes like me logo Genes that share pathways with RAB19: view

Pathways by source for RAB19 Gene

Interacting Proteins for RAB19 Gene

Gene Ontology (GO) - Biological Process for RAB19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA --
genes like me logo Genes that share ontologies with RAB19: view

No data available for SIGNOR curated interactions for RAB19 Gene

Transcripts for RAB19 Gene

mRNA/cDNA for RAB19 Gene

(5) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RAB19 Gene

RAB19, member RAS oncogene family:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB19 Gene

No ASD Table

Relevant External Links for RAB19 Gene

GeneLoc Exon Structure for
RAB19
ECgene alternative splicing isoforms for
RAB19

Expression for RAB19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RAB19 Gene

mRNA differential expression in normal tissues according to GTEx for RAB19 Gene

This gene is overexpressed in Whole Blood (x8.2), Pancreas (x7.9), Colon - Transverse (x6.9), Pituitary (x6.4), and Kidney - Cortex (x5.4).

Protein differential expression in normal tissues from HIPED for RAB19 Gene

This gene is overexpressed in Cerebrospinal fluid (15.4), Platelet (11.6), and Monocytes (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RAB19 Gene



NURSA nuclear receptor signaling pathways regulating expression of RAB19 Gene:

RAB19

SOURCE GeneReport for Unigene cluster for RAB19 Gene:

Hs.583545
genes like me logo Genes that share expression patterns with RAB19: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for RAB19 Gene

Orthologs for RAB19 Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB19 34 35
  • 99.54 (n)
dog
(Canis familiaris)
Mammalia RAB19 34 35
  • 87.1 (n)
mouse
(Mus musculus)
Mammalia Rab19 34 16 35
  • 86.33 (n)
cow
(Bos Taurus)
Mammalia RAB19 34 35
  • 86.18 (n)
rat
(Rattus norvegicus)
Mammalia Rab19 34
  • 86.02 (n)
oppossum
(Monodelphis domestica)
Mammalia RAB19 35
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAB19 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAB19 34 35
  • 74.92 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia rab19 34
  • 72.36 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC555645 34
  • 65.57 (n)
RAB19 35
  • 63 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Rab-RP3 35
  • 47 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rab-19 35
  • 46 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 46 (a)
OneToMany
Species where no ortholog for RAB19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB19 Gene

ENSEMBL:
Gene Tree for RAB19 (if available)
TreeFam:
Gene Tree for RAB19 (if available)

Paralogs for RAB19 Gene

genes like me logo Genes that share paralogs with RAB19: view

Variants for RAB19 Gene

Sequence variations from dbSNP and Humsavar for RAB19 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10215889 -- 140,402,393(+) taggt(C/T)tcagc intron-variant, upstream-variant-2KB
rs10228687 -- 140,422,227(+) actag(A/G)aaaat intron-variant
rs10235144 -- 140,408,296(+) GGAGT(A/G)TTTAT intron-variant
rs10244251 -- 140,424,680(+) atata(C/T)ataca intron-variant
rs10244642 -- 140,425,026(+) catgc(C/T)tacaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB19 Gene

Variant ID Type Subtype PubMed ID
esv2735212 CNV deletion 23290073
esv2762706 CNV loss 21179565
esv3542518 CNV deletion 23714750
esv3615232 CNV loss 21293372
nsv1022919 CNV gain 25217958
nsv1132090 CNV deletion 24896259
nsv522190 CNV gain 19592680
nsv608500 CNV loss 21841781

Variation tolerance for RAB19 Gene

Residual Variation Intolerance Score: 87.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.21; 62.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAB19 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAB19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB19 Gene

Disorders for RAB19 Gene

Relevant External Links for RAB19

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAB19

No disorders were found for RAB19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB19 Gene

Publications for RAB19 Gene

  1. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4 64
  2. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PMID: 19056867) Gonzales P.A. … Knepper M.A. (J. Am. Soc. Nephrol. 2009) 3 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for RAB19 Gene

Sources for RAB19 Gene

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