Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RAB18 Gene

Aliases for RAB18 Gene

  • RAB18, Member RAS Oncogene Family 2 3
  • WARBM3 3 6
  • Ras-Related Protein Rab-18 3
  • RAB18 Small GTPase 3
  • RAB18LI1 3

External Ids for RAB18 Gene

Previous GeneCards Identifiers for RAB18 Gene

  • GC10P027528
  • GC10P027943
  • GC10P027797
  • GC10P027833
  • GC10P027793

Summaries for RAB18 Gene

Entrez Gene Summary for RAB18 Gene

  • The protein encoded by this gene is a member of a family of Ras-related small GTPases that regulate membrane trafficking in organelles and transport vesicles. Knockdown studies is zebrafish suggest that this protein may have a role in eye and brain development. Mutations in this gene are associated with Warburg micro syndrome type 3. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for RAB18 Gene

RAB18 (RAB18, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB18 include warburg micro syndrome 3 and warburg micro syndrome. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB33A.

UniProtKB/Swiss-Prot for RAB18 Gene

  • Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes. Plays a key role in eye and brain development and neurodegeneration.

Gene Wiki entry for RAB18 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB18 Gene

Genomics for RAB18 Gene

Regulatory Elements for RAB18 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RAB18 Gene

27,504,174 bp from pter
27,542,237 bp from pter
38,064 bases
Plus strand

Genomic View for RAB18 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAB18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB18 Gene

Proteins for RAB18 Gene

  • Protein details for RAB18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras-related protein Rab-18
    Protein Accession:
    Secondary Accessions:
    • B3KMC7
    • B7Z333
    • D3DRW1
    • Q53FX8
    • Q56UN9
    • Q6FIH1

    Protein attributes for RAB18 Gene

    206 amino acids
    Molecular mass:
    22977 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RAB18 Gene

    Alternative splice isoforms for RAB18 Gene


neXtProt entry for RAB18 Gene

Proteomics data for RAB18 Gene at MOPED

Post-translational modifications for RAB18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for RAB18 Gene

Domains for RAB18 Gene

Gene Families for RAB18 Gene

  • RAB :RAB, member RAS oncogene

Graphical View of Domain Structure for InterPro Entry



  • Q9NP72
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB18: view

Function for RAB18 Gene

Molecular function for RAB18 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes. Plays a key role in eye and brain development and neurodegeneration.

Gene Ontology (GO) - Molecular Function for RAB18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity NAS 10648831
GO:0005515 protein binding IPI 23935497
GO:0005525 GTP binding IEA --
GO:0019003 GDP binding IDA 20937701
genes like me logo Genes that share ontologies with RAB18: view

Phenotypes for RAB18 Gene

MGI mutant phenotypes for RAB18:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with RAB18: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RAB18 Gene

Localization for RAB18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB18 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

Jensen Localization Image for RAB18 Gene COMPARTMENTS Subcellular localization image for RAB18 gene
Compartment Confidence
plasma membrane 5
cytosol 3
nucleus 2
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RAB18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005634 nucleus --
GO:0005737 cytoplasm --
GO:0005794 Golgi apparatus IBA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with RAB18: view

Pathways for RAB18 Gene

genes like me logo Genes that share pathways with RAB18: view

Pathways by source for RAB18 Gene

1 Qiagen pathway for RAB18 Gene

Gene Ontology (GO) - Biological Process for RAB18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001654 eye development ISS --
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport IBA --
GO:0006913 nucleocytoplasmic transport --
GO:0007165 signal transduction --
genes like me logo Genes that share ontologies with RAB18: view

Transcripts for RAB18 Gene

Unigene Clusters for RAB18 Gene

RAB18, member RAS oncogene family:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAB18

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB18 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e · 9f
SP1: - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - - -
SP9: -

Relevant External Links for RAB18 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RAB18 Gene

mRNA expression in normal human tissues for RAB18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for RAB18 Gene

This gene is overexpressed in Milk (8.9), Bone (7.3), and Peripheral blood mononuclear cells (6.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB18 Gene

SOURCE GeneReport for Unigene cluster for RAB18 Gene Hs.406799

mRNA Expression by UniProt/SwissProt for RAB18 Gene

Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with RAB18: view

Expression partners for RAB18 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for RAB18 Gene

Orthologs for RAB18 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RAB18 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RAB18 35
  • 95.63 (n)
  • 99.51 (a)
RAB18 36
  • 100 (a)
(Canis familiaris)
Mammalia RAB18 35
  • 94.77 (n)
  • 97.84 (a)
RAB18 36
  • 98 (a)
(Mus musculus)
Mammalia Rab18 35
  • 94.01 (n)
  • 99.03 (a)
Rab18 16
Rab18 36
  • 99 (a)
(Pan troglodytes)
Mammalia RAB18 35
  • 100 (n)
  • 100 (a)
RAB18 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rab18 35
  • 93.2 (n)
  • 98.54 (a)
(Monodelphis domestica)
Mammalia RAB18 36
  • 97 (a)
(Ornithorhynchus anatinus)
Mammalia RAB18 36
  • 97 (a)
(Gallus gallus)
Aves RAB18 35
  • 86.57 (n)
  • 97.09 (a)
RAB18 36
  • 97 (a)
(Anolis carolinensis)
Reptilia RAB18 36
  • 95 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rab18 35
  • 79.61 (n)
  • 91.26 (a)
Str.10888 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.2842 35
(Danio rerio)
Actinopterygii rab18b 35
  • 73.66 (n)
  • 88.78 (a)
rab18a 36
  • 82 (a)
rab18b 36
  • 88 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rab-RP4 37
  • 51 (a)
Rab18 35
  • 54.38 (n)
  • 54.19 (a)
Rab-RP4 36
  • 51 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010875 35
  • 57.97 (n)
  • 67.39 (a)
(Caenorhabditis elegans)
Secernentea rab-18 37
  • 72 (a)
rab-18 35
  • 64.94 (n)
  • 72.99 (a)
rab-18 36
  • 67 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC4 36
  • 40 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons RAB18 35
  • 60.98 (n)
  • 62.5 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6152 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 73 (a)
Species with no ortholog for RAB18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB18 Gene

Gene Tree for RAB18 (if available)
Gene Tree for RAB18 (if available)

Paralogs for RAB18 Gene

Paralogs for RAB18 Gene Pseudogenes for RAB18 Gene

genes like me logo Genes that share paralogs with RAB18: view

Variants for RAB18 Gene

Sequence variations from dbSNP and Humsavar for RAB18 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs10020 -- 27,539,063(-) TATTT(C/T)CCCTC utr-variant-3-prime, nc-transcript-variant
rs1047915 -- 27,541,990(+) TAAAG(A/T)TGTTT utr-variant-3-prime, nc-transcript-variant
rs2172678 -- 27,535,730(+) GTTCT(A/G)GGAGA intron-variant
rs2242356 -- 27,533,887(+) TTCTA(A/T)ATTTT intron-variant
rs2248059 -- 27,511,268(+) cacca(A/T)ctcag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB18 Gene

Variant ID Type Subtype PubMed ID
nsv8614 CNV Loss 18304495
esv2734606 CNV Deletion 23290073
nsv825319 CNV Loss 20364138
esv2671913 CNV Deletion 23128226
esv2734617 CNV Deletion 23290073

Relevant External Links for RAB18 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB18 Gene

Disorders for RAB18 Gene

(1) OMIM Diseases for RAB18 Gene (602207)


  • Warburg micro syndrome 3 (WARBM3) [MIM:614222]: A rare syndrome characterized by microcephaly, microphthalmia, microcornia, congenital cataracts, optic atrophy, cortical dysplasia, in particular corpus callosum hypoplasia, severe mental retardation, spastic diplegia, and hypogonadism. {ECO:0000269 PubMed:21473985}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for RAB18 Gene

genes like me logo Genes that share disorders with RAB18: view

No data available for Novoseek inferred disease relationships , Genatlas and External Links for RAB18 Gene

Publications for RAB18 Gene

  1. Isolation and characterisation of the human rab18 gene after stimulation of endothelial cells with histamine. (PMID: 10648831) Schaefer U. … Neugebauer E. (FEBS Lett. 2000) 2 3 4
  2. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu R.-M. … Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for RAB18 Gene

Sources for RAB18 Gene

Back to Top