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Aliases & Descriptions for RAB18
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| OTTHUMP00000019371 2 | | RAB18LI1 2 |
| | | Descriptions |
|---|
| RAB18 small GTPase 2 | | RAB18, member RAS oncogene family 2 |
|
| | Search outside databases for aliases for RAB18 genePrevious GC identifers: GC10P027528 GC10P027943 GC10P027797 |
Summaries for RAB18(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: RAB18_HUMAN, Q9NP72Function: Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes (By similarity)Gene Wiki entry for RAB18 |
Genomic Location for RAB18
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the RAB18 gene 
Entrez Gene cytogenetic band: 10p12.1 Ensembl cytogenetic band: 10p12.1 HGNC cytogenetic band: 10p12RAB18 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P027833:
(about GC identifiers)
Start:
|
27,833,255 bp from pter |
End:
|
27,869,105 bp from pter |
Size:
|
35,851 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000010.9 NT_008705.15
| Proteins for RAB18
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: RAB18_HUMAN, Q9NP72 (See
protein sequence)Recommended Name: Ras-related protein Rab-18 Size: 206 amino acids; 22977 Da
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
PDB structures from and Proteopedia :1X3S (3D)
 
Secondary accessions: Q53FX8 Q6FIH1Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_067075.1
ENSEMBL proteins: ENSP00000349415 ENSP00000364957 ENSP00000379554 ENSP00000364960
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: RAB18 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for RAB18: Assays for RAB18: | Protein
Domains/ Families for RAB18(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9NP72
ProtoNet protein and cluster: Q9NP72 1 Blocks protein family: IPB001806 Transforming protein P21 RAS signature
UniProtKB/Swiss-Prot: RAB18_HUMAN, Q9NP72Similarity: Belongs to the small GTPase superfamily. Rab family | Gene Function for RAB18
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_021252
Applied Biosystems Silencer® siRNAs for RAB18
Sigma-Aldrich siRNA for RAB18  Sigma-Aldrich shRNA for RAB18  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_021252                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_021252                                  untagged cDNA clone in CMV expression vector: NM_021252 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_021252
UniProtKB/Swiss-Prot: RAB18_HUMAN, Q9NP72Function: Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes (By similarity)3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for RAB18
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for RAB18 
2 Interacting proteins for RAB18 (ENSP000003649573) via UniProtKB, MINT, and/or STRINGAbout this table
3 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for RAB18(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|  |
Enzo Life Sciences drugs & compounds for RAB18 |
Browse Tocris compounds for RAB18
|
Transcripts for RAB18(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_021252
Sigma-Aldrich siRNA for RAB18  Sigma-Aldrich shRNA for RAB18  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_021252 REFSEQ mRNAs for RAB18 gene: NM_021252.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_021252               OriGene GFP tagged cDNA clone in CMV expression vector: NM_021252                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_021252                                  untagged cDNA clone in CMV expression vector: NM_021252  Additional cDNA sequence: AB209698.1 AF087860.1 AF136974.1 AF137372.1 AF498950.1 AF532968.1 AK001555.1 AK090947.1 AK223153.1 AK295443.1 AK297629.1 AK299457.1 AL136734.1 AY574034.1 BC015014.2 BC029350.1 BT009840.1 CR533455.1 CR590751.1 CR599854.1 24/25 DOTS entries (see all 25
): DT.101985243 DT.100662115 DT.100662119 DT.318025 DT.412143 DT.92446118 DT.100662118 DT.95160609 DT.92446095 DT.92446098 DT.100741772 DT.102833242 DT.121240156 DT.121240182 DT.121240191 DT.121240230 DT.121240232 DT.121240303 DT.408112 DT.408113 DT.100662122 DT.100720974 DT.121240209 DT.91977026 24/344 AceView cDNA sequences (see all 344
):AI160382 BM128820 BM678414 CR533455 AI569871 AW008823 CR590751 CB134219 AA987308 BM129064 BQ694722 F06024 BM128819 AA207009 AA634494 AF498950 AF137372 T11345 F09812 AI863868 N66417 CB137224 BQ015181 AA417600
highest scoring ESTs for RAB18:AI337016 AA126679 AA127563 AA127564 AA156821 AA207009 AA207100 AA214162 AA214212 AA216601 Unigene Cluster for RAB18: RAB18, member RAS oncogene family Hs.406799 [show with all ESTs]Unigene Representative Sequence: AB209698
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for RAB18 (see all 9
)
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | · | 9d | · | 9e | · | 9f | |
| SP1: | |   | |   | |   | |   | - |   | |   | - |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | - |   | |   | - |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | - |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | - |   | |   | - |   | |   | - |   | - |   | - |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | - |   | |   | - |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for RAB18
4 Ensembl transcripts including schematic representations: ENST00000356940
ENST00000375800
ENST00000396255
ENST00000375802
|
Expression for RAB18
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| RAB18 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for RAB18
1 / 2 / 3 11 probe-sets matching RAB18 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.406799 UniProtKB/Swiss-Prot: RAB18_HUMAN, Q9NP72Tissue specificity: Ubiquitous |
Orthologs for RAB18
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for RAB18 gene from 5/16 species (see all 16
)
About this table Species with no ortholog for RAB18
ENSEMBL Gene Tree for RAB18 | Paralogs for RAB18(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for RAB18(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for RAB18 (up to first 250kb)
|
Disorders & Mutations for RAB18
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 602207
|
Medical News for RAB18(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for RAB18 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/26 PubMed articles for RAB18 gene (see all 26
): |
Search for RAB18
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing RAB18
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing RAB18
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RAB18(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for RAB18(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for RAB18:

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Incremental update: 13 Oct 2009
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