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RAB18 Gene

protein-coding   GIFtS: 54

GC10P027833
RAB18, member RAS oncogene family
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
OTTHUMP00000019371 2
RAB18LI1 2
Descriptions
RAB18 small GTPase 2
RAB18, member RAS oncogene family 2
External Ids
HGNC: 142441
Entrez Gene: 229312
UniProtKB: Q9NP723
Ensembl: ENSG000000992467
Search outside databases for aliases for RAB18 gene

Previous GC identifers: GC10P027528 GC10P027943 GC10P027797

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: RAB18_HUMAN, Q9NP72
Function: Plays a role in apical endocytosis/recycling. May be implicated in transport between the
plasma membrane and early endosomes (By similarity)

Gene Wiki entry for RAB18

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the RAB18 gene  

Entrez Gene cytogenetic band: 10p12.1   Ensembl cytogenetic band:  10p12.1   HGNC cytogenetic band: 10p12

RAB18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P027833:     (about GC identifiers)

Start:
27,833,255 bp from pter
End:
27,869,105 bp from pter
Size:
35,851 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000010.9  NT_008705.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: RAB18_HUMAN, Q9NP72 (See protein sequence)
Recommended Name: Ras-related protein Rab-18  
Size: 206 amino acids; 22977 Da
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
PDB structures from and Proteopedia :
1X3S (3D)    
Secondary accessions: Q53FX8 Q6FIH1

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_067075.1  

    ENSEMBL proteins: 
    ENSP00000349415 ENSP00000364957 ENSP00000379554 ENSP00000364960 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse Abcam for Recombinant Proteins
    Human Recombinant Proteins from Abnova (RAB18)
                  OriGene Purified Recombinant Human Protein: RAB18 

    3 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575 cellular_component ND--
    GO:0005622 intracellular IDA11256614
    GO:0005886 plasma membrane IEA--
    About this table

    Antibodies for RAB18: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for RAB18
    Browse R&D Systems for Antibodies
    Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
    Monoclonal and Polyclonal Antibodies from Abnova (RAB18)
    Novus Biologicals Antibodies for RAB18

    Assays for RAB18: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5 InterPro domains/families:
     IPR001806 Ras_GTPase
     IPR005225 Small_GTP_bd
     IPR003579 GTPase_Rab
     IPR015598 Rab18
     IPR013753 Ras


       GeneDecks  RAB18 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q9NP72

    ProtoNet protein and cluster: Q9NP72

    1 Blocks protein family: IPB001806 Transforming protein P21 RAS signature

    UniProtKB/Swiss-Prot: RAB18_HUMAN, Q9NP72
    Similarity: Belongs to the small GTPase superfamily. Rab family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (RAB18)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (RAB18)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_021252

                  Applied Biosystems Silencer® siRNAs for RAB18

                  Sigma-Aldrich siRNA for RAB18  
                         Sigma-Aldrich shRNA for RAB18  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for RAB18
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_021252
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_021252
                                     untagged cDNA clone in CMV expression vector: NM_021252 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_021252

    UniProtKB/Swiss-Prot: RAB18_HUMAN, Q9NP72
    Function: Plays a role in apical endocytosis/recycling. May be implicated in transport between the
    plasma membrane and early endosomes (By similarity)

    3 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0003924 GTPase activity NAS10648831
    GO:0005525 GTP binding IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


     Gene Network CentralTM Interacting Genes and Proteins Network for  RAB18 


    2 Interacting proteins for RAB18 (ENSP000003649573) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    M6PRBP1ENSP000002219573STRING (score=.708)
    ADFPENSP000002769143STRING (score=.704)
    About this table

    3 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006897 endocytosis NAS--
    GO:0007264 small GTPase mediated signal transduction NAS10648831
    GO:0015031 protein transport IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Enzo Life Sciences drugs & compounds for RAB18
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for RAB18

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (RAB18)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (RAB18)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_021252

                  Sigma-Aldrich siRNA for RAB18  
                         Sigma-Aldrich shRNA for RAB18  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_021252  

    REFSEQ mRNAs for RAB18 gene: 

    NM_021252.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_021252  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_021252
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_021252
                                     untagged cDNA clone in CMV expression vector: NM_021252 

    Additional cDNA sequence: 

    AB209698.1 AF087860.1 AF136974.1 AF137372.1 AF498950.1 AF532968.1 AK001555.1 AK090947.1 
    AK223153.1 AK295443.1 AK297629.1 AK299457.1 AL136734.1 AY574034.1 BC015014.2 BC029350.1 
    BT009840.1 CR533455.1 CR590751.1 CR599854.1 

    24/25 DOTS entries (see all 25 ):

    DT.101985243  DT.100662115  DT.100662119  DT.318025  DT.412143  DT.92446118  DT.100662118  DT.95160609 
    DT.92446095  DT.92446098  DT.100741772  DT.102833242  DT.121240156  DT.121240182  DT.121240191  DT.121240230 
    DT.121240232  DT.121240303  DT.408112  DT.408113  DT.100662122  DT.100720974  DT.121240209  DT.91977026 

    24/344 AceView cDNA sequences (see all 344 ):

    AI160382 BM128820 BM678414 CR533455 AI569871 AW008823 CR590751 CB134219 
    AA987308 BM129064 BQ694722 F06024 BM128819 AA207009 AA634494 AF498950 
    AF137372 T11345 F09812 AI863868 N66417 CB137224 BQ015181 AA417600 

    highest scoring ESTs for RAB18:

    AI337016 AA126679 AA127563 AA127564 AA156821 AA207009 AA207100 AA214162 AA214212 AA216601 

    Unigene Cluster for RAB18:

    RAB18, member RAS oncogene family
    Hs.406799  [show with all ESTs]
    Unigene Representative Sequence: AB209698


    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for RAB18 (see all 9 )

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e · 9f
    SP1:                          -           -           -           -                                                               
    SP2:                          -           -           -     -     -                                                               
    SP3:                                      -           -     -     -                                                               
    SP4:                          -           -           -     -     -                 -     -                                       
    SP5:                          -           -           -     -     -                                                               

    About this scheme

    ECgene alternative splicing isoforms for RAB18

    4 Ensembl transcripts including schematic representations:
    ENST00000356940  ENST00000375800  ENST00000396255  ENST00000375802  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    RAB18 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for RAB18

    1 / 2 / 3

    11 probe-sets matching RAB18 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    64232_at2, 3 U95-C 1 1.00 1.00 0.72 0.47 AI769954 0.40 1.00 0.76 1

    78719_at2, 3 U95-E 1 1.00 1.00 0.61 1.40 AI337016 1.00 1.00 1.00 1

    65764_at2, 3 U95-C 2 1.00 0.97 0.72 1.14 D12273 0.80 1.00 0.91 1

    223336_s_at2, 3 U133-B 1 1.00 1.00 -- -- AL136734 0.80 1.00 0.91 1

    224787_s_at2, 3 U133-B 1 1.00 1.00 -- -- AI333232 0.80 1.00 0.91 1

    224377_s_at2, 3 U133-B 1 1.00 1.00 -- -- AF274957 0.60 1.00 0.82 1

    229398_at2, 3 U133-B 1 0.91 1.00 -- -- AI769954 0.40 1.00 0.76 1

    223336_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    224787_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    224377_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    229398_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.406799

    UniProtKB/Swiss-Prot: RAB18_HUMAN, Q9NP72
    Tissue specificity: Ubiquitous

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for RAB18 gene from 5/16 species (see all 16 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    RAB181   -- RAB18, member RAS oncogene family 95.15(n)
    98.54(a)
    491408  XM_548529.2  XP_548529.2 
    chimpanzee
    (Pan troglodytes)
    RAB181   -- RAB18, member RAS oncogene family 97.08(n)
    96.39(a)
    450372  XM_507716.2  XP_507716.1 
    cow
    (Bos taurus)
    RAB181   -- RAB18, member RAS oncogene family 95.63(n)
    99.51(a)
    511160  NM_001075499.1  NP_001068967.1 
    rat
    (Rattus norvegicus)
    Rab181   -- RAB18, member RAS oncogene family 93.2(n)
    98.54(a)
    307039  NM_001012468.1  NP_001012486.1 
    mouse
    (Mus musculus)
    Rab181, 5 18 (7.50 cM)5
    RAB18, member RAS oncogene family1, 5 94.01(n)1
    99.03(a)1
    193301  NM_011225.11  NP_035355.11 
     AA4090235  AA9596865  (see all 28)
    About this table        Species with no ortholog for RAB18

    ENSEMBL Gene Tree for RAB18
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

      --
    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/185 NCBI SNPs in RAB18 are shown (see all 185 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 98)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 10 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs27633061,2
    A,C,F,H,O27867547(-) TCATCC/TGAACA 1 -- ut31 ese34Minor allele frequency- T:0.03EU EA WA 416
    rs105087231,2
    A,C,F,H27868398(+) TTCTAC/TTTGAT 1 -- ut31 ese312Minor allele frequency- T:0.06NS EU EA WA NA 668
    rs107646991,2
    A,C,F,H27832938(+) GCTGCC/TGAAAT 1 -- ng5112Minor allele frequency- T:0.21NA EA MN EU WA 1230
    rs107646981,2
    A,C,F,H27832095(+) aaagtG/Agtaaa 1 -- ng514Minor allele frequency- A:0.49EU EA WA 412
    --
    rs105087221,2
    C,F,H27867744(+) GGAGGA/TCATGA 1 -- ut31 ese313Minor allele frequency- T:0.09NS EU EA WA NA 738
    rs24773171,2
    C,F,H27869361(+) TAGTTA/GCCAGC 1 -- ng3111Minor allele frequency- G:0.09NA EU EA WA 976
    --
    rs110158591,2
    C,F,H27866957(+) GAGGAG/ACCTGT 1 T/A mis1 ese3 trp38Minor allele frequency- A:0.03EU EA WA 836
    rs122487401,2
    A,F,H27867373(+) CCTAGC/AACCAC 1 -- ut314Minor allele frequency- A:0.08EU EA WA 420
    rs125718361,2
    C,F,H27867490(+) AAGCAA/GAATTC 1 -- ut3110Minor allele frequency- G:0.16NA EU EA WA 830
    rs25053021,2
    C,F,H27833008(+) TGAGGT/CTGGGG 1 -- ng514Minor allele frequency- C:0.01EU EA WA 416
    About this table

    HapMap Linkage Disequilibrium images for RAB18 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 602207

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/26 PubMed articles for RAB18 gene (see all 26 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 22931 HGNC: 14244 AceView: RAB18 Ensembl:ENSG00000099246 euGenes: HUgn22931
    ECgene: RAB18 H-InvDB: RAB18
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for RAB18 Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for RAB18:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for RAB18 Browse small molecules at Sigma-Aldrich
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     Drugs for RAB18
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