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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RAB18 Gene

protein-coding   GIFtS: 57
GCID: GC10P027793

RAB18, Member RAS Oncogene Family

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
RAB18, Member RAS Oncogene Family1 2
RAB18LI12
WARBM32
RAB18 Small GTPase2
Ras-Related Protein Rab-182

External Ids:    HGNC: 142441   Entrez Gene: 229312   Ensembl: ENSG000000992467   OMIM: 6022075   UniProtKB: Q9NP723   

Export aliases for RAB18 gene to outside databases

Previous GC identifers: GC10P027528 GC10P027943 GC10P027797 GC10P027833


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RAB18 Gene:
The protein encoded by this gene is a member of a family of Ras-related small GTPases that regulate membrane
trafficking in organelles and transport vesicles. Knockdown studies is zebrafish suggest that this protein may
have a role in eye and brain development. Mutations in this gene are associated with Warburg micro syndrome type
3. Alternatively spliced transcript variants have been found for this gene. (provided by RefSeq, Jan 2012)

GeneCards Summary for RAB18 Gene: 
RAB18 (RAB18, member RAS oncogene family) is a protein-coding gene. Diseases associated with RAB18 include warburg micro syndrome 3, and warburg micro syndrome, and among its related super-pathways are Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include GDP binding and GTP binding. An important paralog of this gene is DNAJC27.

UniProtKB/Swiss-Prot: RAB18_HUMAN, Q9NP72
Function: Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane
and early endosomes. Plays a key role in eye and brain development and neurodegeneration

Gene Wiki entry for RAB18 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.2  NT_008705.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RAB18 gene promoter:
         Nkx3-1   Max1   Nkx3-1 v4   Pax-5   HTF   Nkx3-1 v1   Nkx3-1 v2   Nkx3-1 v3   Sox9   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RAB18 promoter sequence
   Search SABiosciences Chromatin IP Primers for RAB18

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p12.1   Ensembl cytogenetic band:  10p12.1   HGNC cytogenetic band: 10p12

RAB18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAB18 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P027793:  view genomic region     (about GC identifiers)

Start:
27,793,197 bp from pter      End:
27,831,143 bp from pter
Size:
37,947 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RAB18_HUMAN, Q9NP72 (See protein sequence)
Recommended Name: Ras-related protein Rab-18 precursor  
Size: 206 amino acids; 22977 Da
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
1 PDB 3D structure from and Proteopedia for RAB18:
1X3S (3D)    
Secondary accessions: B3KMC7 B7Z333 D3DRW1 Q53FX8 Q56UN9 Q6FIH1
Alternative splicing: 3 isoforms:  Q9NP72-1   Q9NP72-2   Q9NP72-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RAB18: NX_Q9NP72

Explore proteomics data for RAB18 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NP72

  • RAB18 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RAB18 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001243339.1  NP_001243340.1  NP_001243341.1  NP_001243344.1  NP_067075.1  

    ENSEMBL proteins: 
     ENSP00000349415   ENSP00000364960   ENSP00000407872   ENSP00000439321  

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    Cloud-Clone Corp. Proteins for RAB18 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----

    RAB18 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RAB: RAB, member RAS oncogene

    5 InterPro protein domains:
     IPR025662 Sigma_54_int_dom_ATP-bd_1
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR003579 Small_GTPase_Rab_type
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q9NP72

    ProtoNet protein and cluster: Q9NP72

    1 Blocks protein domain: IPB001806 Transforming protein P21 RAS signature

    UniProtKB/Swiss-Prot: RAB18_HUMAN, Q9NP72
    Similarity: Belongs to the small GTPase superfamily. Rab family


    RAB18 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RAB18_HUMAN, Q9NP72
    Function: Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane
    and early endosomes. Plays a key role in eye and brain development and neurodegeneration

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity NAS10648831
    GO:0005525GTP binding IEA--
    GO:0019003GDP binding IDA--
         
    RAB18 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Rab18):
     no phenotypic analysis 

    RAB18 for phenotypes           About GeneDecksing

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidRAB18 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RAB18 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions0.36

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RAB18
        Epithelial Tight Junctions



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAB18

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/14 Interacting proteins for RAB18 (Q9NP723 ENSP000003494154) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP2R1AP301533, ENSP000003248044I2D: score=3 STRING: ENSP00000324804
    PPP2R1BP301543, ENSP000003113444I2D: score=3 STRING: ENSP00000311344
    TOM1L1O756743, ENSP000004089584I2D: score=3 STRING: ENSP00000408958
    CHMP243863, ENSP000003503864I2D: score=1 STRING: ENSP00000350386
    PDE6DO439243, ENSP000002876004I2D: score=4 STRING: ENSP00000287600
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001654eye development ISS--
    GO:0006184GTP catabolic process NAS10648831
    GO:0006886intracellular protein transport ----
    GO:0006897endocytosis NAS--
    GO:0006913nucleocytoplasmic transport ----

    RAB18 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RAB18

    Search CenterWatch for drugs/clinical trials and news about RAB18

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RAB18 gene (5 alternative transcripts): 
    NM_001256410.1  NM_001256411.1  NM_001256412.1  NM_001256415.1  NM_021252.4  

    Unigene Cluster for RAB18:

    RAB18, member RAS oncogene family
    Hs.406799  [show with all ESTs]
    Unigene Representative Sequence: AB209698
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356940(uc001itv.3 uc001itw.3 uc010qdq.2 uc010qdr.2)
    ENST00000490236 ENST00000375802 ENST00000465772 ENST00000484281 ENST00000423465
    ENST00000535776

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    hsa-miR-3163 hsa-miR-455-5p hsa-miR-429 hsa-miR-338-5p hsa-miR-200c hsa-miR-4274 hsa-miR-19b hsa-miR-2276
    SwitchGear 3'UTR luciferase reporter plasmidRAB18 3' UTR sequence
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    Additional mRNA sequence: 

    AB209698.1 AF087860.1 AF136974.1 AF137372.1 AF498950.1 AF532968.1 AK001555.1 AK090947.1 
    AK223153.1 AK295443.1 AK297629.1 AK299457.1 AL136734.1 AY574034.1 BC015014.2 BC029350.1 
    BT009840.1 CR533455.1 NR_046172.1 

    24/26 DOTS entries (see all 26):

    DT.101985243  DT.100662115  DT.100662119  DT.318025  DT.412143  DT.92446118  DT.100662118  DT.206369 
    DT.95160609  DT.92446095  DT.92446098  DT.100741772  DT.102833242  DT.121240156  DT.121240182  DT.121240191 
    DT.121240230  DT.121240232  DT.121240303  DT.408113  DT.100662122  DT.100698239  DT.100720974  DT.121240209 

    24/344 AceView cDNA sequences (see all 344):

    AA741560 CK725191 CB137224 AU280411 AF498950 AI366793 BU902431 AL136734 
    BM463268 AL533144 BI090216 BQ694722 AA581852 BM468299 CR533455 AF532968 
    AW008823 F02269 T11345 C02605 AA741382 BE739077 AW194172 BM128819 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for RAB18 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e · 9f
    SP1:                          -           -           -           -                                                               
    SP2:                          -           -           -     -     -                                                               
    SP3:                                      -           -     -     -                                                               
    SP4:                          -           -           -     -     -                 -     -                                       
    SP5:                          -           -           -     -     -                                                               


    ECgene alternative splicing isoforms for RAB18

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RAB18 expression in normal human tissues (normalized intensities)      RAB18 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RAB18 Expression
    About this image


    RAB18 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/29 selected tissues (see all 29) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
             brain/midbrain   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Uterus (Reproductive System)    fully expand to see all 3 entries
             cervix, uterine ; glandular cells   
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Hepatocytes Liver Lobule
             liver ; bile duct cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 2 entries
             rectum ; glandular cells   

    See RAB18 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RAB18

    SOURCE GeneReport for Unigene cluster: Hs.406799

    UniProtKB/Swiss-Prot: RAB18_HUMAN, Q9NP72
    Tissue specificity: Ubiquitous

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RAB18 gene from 8/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rab181 , 5 RAB18, member RAS oncogene family1, 5 94.01(n)1
    99.03(a)1
      18 (4.53 cM)5
    193301  NM_181070.51  NP_851415.11 
     67652055 
    chicken
    (Gallus gallus)
    Aves RAB181 RAB18, member RAS oncogene family 86.57(n)
    97.09(a)
      420483  NM_001006355.1  NP_001006355.1 
    lizard
    (Anolis carolinensis)
    Reptilia RAB186
    --
    --
    95(a)
    57(a)
    1 ↔ 1
    possible ortholog
    5(669192-686780)
    6(78137820-78159937)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.28422 Xenopus laevis, Similar to RAB18, member RAS oncogene more 81.8(n)    BC043996.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rab18b1 RAB18B, member RAS oncogene family 73.66(n)
    88.78(a)
      445055  NM_001003449.1  NP_001003449.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rab-RP41 , 3 GTP binding3
    Rab-related protein 41
    51(a)3
    53.58(n)1
    53.4(a)1
      5A113
    443601  NM_080005.31  NP_524744.21 
    worm
    (Caenorhabditis elegans)
    Secernentea rab-181 , 3 Protein RAB-181 72(a)3
    62.37(n)1
    68.56(a)1
      III(1151500-1152299)3
    1752721  NM_171081.31  NP_741092.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons RABC2A1 RAB GTPase-C2A 59.96(n)
    58.58(a)
      831810  NM_120433.2  NP_568121.1 


    ENSEMBL Gene Tree for RAB18 (if available)
    TreeFam Gene Tree for RAB18 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RAB18 gene
    DNAJC272  
    18/93 SIMAP similar genes for RAB18 using alignment to 3 protein entries:     RAB18_HUMAN (see all proteins) (see all similar genes):
    rab1b    DKFZp686J06205    RAB3A    RAB17    RAB30    RAB8B
    RAB43    RAB15    RAB10    RAB2B    RAB11A    RAB19
    RAB7A    RAB13    RAB38    RAB8A    RAB3B    RAB7L1

    RAB18 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for RAB18
    PGOHUM00000238395 PGOHUM00000238708 PGOHUM00000243734


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/758 SNPs in RAB18 are shown (see all 758)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0664954
    Warburg micro syndrome 3 (WARBM3)4--see VAR_0664952 L Q mis40--------
    rs760297141,2
    C--27525711(+) TTAAT-/AT/TA 
            
    TGTTA
    6 -- int10--------
    rs106550721,2
    C--27530889(+) TTTTT-/TTAAAGC 6 -- int1 trp30--------
    rs1459753051,2
    C--27533058(+) TGTAT-/AATT/ATT
    A
    /GTATATTA
    ATTCT
    6 -- int10--------
    rs2005821511,2
    --27539151(+) CATTG-/CTTCTTTC 6 -- int10--------
    rs722647161,2
    C--27539153(+) TTGCT-/TCTTTCT 6 -- int11Minor allele frequency- TC:0.50CSA 2
    rs724838581,2
    C--27541535(+) CGAGA-/CTCTGTC 6 -- int10--------
    rs38326571,2
    C--27547316(-) CATGCA/-CAATT 6 -- ut31 nc-transcript-variant1Minor allele frequency- -:0.00CSA 2
    rs1892575081,2
    --27697447(+) TGATAC/TTGCCA 6 -- us2k10--------
    rs1422636901,2
    C--27697479(+) TGCAA-/AGAGAT 6 -- us2k10--------

    HapMap Linkage Disequilibrium report for RAB18 (27793197 - 27831143 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for RAB18:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2734617CNV Deletion23290073
    esv2671913CNV Deletion23128226
    esv2734606CNV Deletion23290073
    nsv825319CNV Loss20364138
    nsv8614CNV Loss18304495


    Human Gene Mutation Database (HGMD): RAB18
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RAB18
    DNA2.0 Custom Variant and Variant Library Synthesis for RAB18

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602207    OMIM disorders: --

    UniProtKB/Swiss-Prot: RAB18_HUMAN, Q9NP72
  • Warburg micro syndrome 3 (WARBM3) [MIM:614222]: A rare syndrome characterized by microcephaly,
    microphthalmia, microcornia, congenital cataracts, optic atrophy, cortical dysplasia, in particular corpus
    callosum hypoplasia, severe mental retardation, spastic diplegia, and hypogonadism. Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • 18 diseases for RAB18:    About MalaCards
    warburg micro syndrome 3    warburg micro syndrome    micro syndrome    childhood medulloblastoma
    large cell medulloblastoma    spastic diplegia    medulloblastoma    hemophagocytic lymphohistiocytosis
    optic atrophy    acromegaly    hypogonadism    pituitary tumors
    microphthalmia    microcephaly    cataract    spasticity
    mental retardation    endotheliitis

    2 diseases from the University of Copenhagen DISEASES database for RAB18:
    Large cell medulloblastoma     Hormone producing pituitary cancer

    RAB18 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Export disorders for RAB18 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RAB18 gene, integrated from 9 sources (see all 38):
    (articles sorted by number of sources associating them with RAB18)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterisation of the human rab18 gene after stimulation of endothelial cells with histamine. (PubMed id 10648831)1, 2, 3 Schaefer U.... Neugebauer E. (2000)
    2. Loss-of-function mutations in RAB18 cause Warburg mic ro syndrome. (PubMed id 21473985)1, 2 Bem D....Aligianis I.A. (2011)
    3. Cloning and characterization of a novel splice variant of human Rab18 gene (RAB18). (PubMed id 16147880)1, 2 Dou T.... Mao Y. (2005)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    7. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    8. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (2000)
    9. Hepatitis B virus X protein upregulates oncogene Rab18 to result in the dysregulation of lipogenesis and proliferation of hepatoma cel ls. (PubMed id 23471881)1 You X....Zhang X. (2013)
    10. Novel, gel-free proteomics approach identifies RNF5 an d JAMP as modulators of GPCR stability. (PubMed id 23798571)1 Roy S.J....Parent J.L. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 22931 HGNC: 14244 AceView: RAB18 Ensembl:ENSG00000099246 euGenes: HUgn22931
    ECgene: RAB18 H-InvDB: RAB18

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RAB18 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAB18 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RAB18 gene:
    Search GeneIP for patents involving RAB18

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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