Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



RAB18 Gene

protein-coding   GIFtS: 57
GCID: GC10P027793

RAB18, Member RAS Oncogene Family

  See RAB18-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
RAB18, Member RAS Oncogene Family1 2
WARBM32 5
RAB18LI12
RAB18 Small GTPase2
Ras-Related Protein Rab-182

External Ids:    HGNC: 142441   Entrez Gene: 229312   Ensembl: ENSG000000992467   OMIM: 6022075   UniProtKB: Q9NP723   

Export aliases for RAB18 gene to outside databases

Previous GC identifers: GC10P027528 GC10P027943 GC10P027797 GC10P027833


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for RAB18 Gene:
The protein encoded by this gene is a member of a family of Ras-related small GTPases that regulate membrane
trafficking in organelles and transport vesicles. Knockdown studies is zebrafish suggest that this protein may
have a role in eye and brain development. Mutations in this gene are associated with Warburg micro syndrome type
3. Alternatively spliced transcript variants have been found for this gene. (provided by RefSeq, Jan 2012)

GeneCards Summary for RAB18 Gene:
RAB18 (RAB18, member RAS oncogene family) is a protein-coding gene. Diseases associated with RAB18 include warburg micro syndrome 3, and warburg micro syndrome. GO annotations related to this gene include GDP binding and GTP binding. An important paralog of this gene is RAB35.

UniProtKB/Swiss-Prot: RAB18_HUMAN, Q9NP72
Function: Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane
and early endosomes. Plays a key role in eye and brain development and neurodegeneration

Gene Wiki entry for RAB18 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_008705.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the RAB18 gene promoter:
         Nkx3-1   Max1   Nkx3-1 v4   Pax-5   HTF   Nkx3-1 v1   Nkx3-1 v2   Nkx3-1 v3   Sox9   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RAB18 promoter sequence
   Search Chromatin IP Primers for RAB18

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RAB18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p12.1   Ensembl cytogenetic band:  10p12.1   HGNC cytogenetic band: 10p12

RAB18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAB18 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P027793:  view genomic region     (about GC identifiers)

Start:
27,793,197 bp from pter      End:
27,831,143 bp from pter
Size:
37,947 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RAB18_HUMAN, Q9NP72 (See protein sequence)
Recommended Name: Ras-related protein Rab-18 precursor  
Size: 206 amino acids; 22977 Da
1 PDB 3D structure from and Proteopedia for RAB18:
1X3S (3D)    
Secondary accessions: B3KMC7 B7Z333 D3DRW1 Q53FX8 Q56UN9 Q6FIH1
Alternative splicing: 3 isoforms:  Q9NP72-1   Q9NP72-2   Q9NP72-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RAB18: NX_Q9NP72

Explore proteomics data for RAB18 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RAB18 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001243339.1  NP_001243340.1  NP_001243341.1  NP_001243344.1  NP_067075.1  

    ENSEMBL proteins: 
     ENSP00000349415   ENSP00000364960   ENSP00000407872   ENSP00000439321  

    RAB18 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for RAB18
    OriGene Protein Over-expression Lysate for RAB18
    OriGene MassSpec for RAB18
    OriGene Custom Protein Services for RAB18
    GenScript Custom Purified and Recombinant Proteins Services for RAB18
    Novus Biologicals RAB18 Proteins
    Novus Biologicals RAB18 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for RAB18
    Cloud-Clone Corp. Proteins for RAB18

     
    Search eBioscience for Proteins for RAB18 

    RAB18 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for RAB18
    OriGene Custom Antibody Services for RAB18
    Novus Biologicals RAB18 Antibodies
    Abcam antibodies for RAB18
    Cloud-Clone Corp. Antibodies for RAB18
    ThermoFisher Antibodies for RAB18
    LSBio Antibodies in human, mouse, rat for RAB18

    RAB18 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RAB18
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RAB18
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RAB18
    Cloud-Clone Corp. CLIAs for RAB18
    Search eBioscience for ELISAs for RAB18 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    RAB: RAB, member RAS oncogene

    5 InterPro protein domains:
     IPR025662 Sigma_54_int_dom_ATP-bd_1
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR003579 Small_GTPase_Rab_type
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q9NP72

    ProtoNet protein and cluster: Q9NP72

    1 Blocks protein domain: IPB001806 Transforming protein P21 RAS signature

    UniProtKB/Swiss-Prot: RAB18_HUMAN, Q9NP72
    Similarity: Belongs to the small GTPase superfamily. Rab family


    Find genes that share domains with RAB18           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RAB18_HUMAN, Q9NP72
    Function: Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane
    and early endosomes. Plays a key role in eye and brain development and neurodegeneration

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity NAS10648831
    GO:0005515protein binding IPI--
    GO:0005525GTP binding IEA--
    GO:0019003GDP binding IDA--
         
    Find genes that share ontologies with RAB18           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Rab18):
     no phenotypic analysis 

    Find genes that share phenotypes with RAB18           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RAB18
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RAB18

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RAB18
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RAB18

    miRNA
    Products:
        
    miRTarBase miRNAs that target RAB18:
    hsa-mir-10a-5p (MIRT047576), hsa-mir-30b-5p (MIRT046127), hsa-mir-26a-5p (MIRT050093), hsa-mir-324-3p (MIRT042858), hsa-mir-30c-5p (MIRT047906)

    Block miRNA regulation of human, mouse, rat RAB18 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RAB18 (see all 13):
    hsa-miR-3163 hsa-miR-455-5p hsa-miR-429 hsa-miR-338-5p hsa-miR-200c hsa-miR-4274 hsa-miR-19b hsa-miR-2276
    SwitchGear 3'UTR luciferase reporter plasmidRAB18 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RAB18
    Predesigned siRNA for gene silencing in human, mouse, rat RAB18

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RAB18

    Clone
    Products:
         
    OriGene clones in human, mouse for RAB18 (see all 7)
    OriGene ORF clones in mouse, rat for RAB18
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RAB18 (NM_021252)
    Sino Biological Human cDNA Clone for RAB18
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAB18
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB18

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RAB18
    Browse ESI BIO Cell Lines and PureStem Progenitors for RAB18 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB18


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    RAB18_HUMAN, Q9NP72: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol3
    nucleus2
    golgi apparatus1
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----

    Find genes that share ontologies with RAB18           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for RAB18 About    
    See pathways by source

    SuperPathContained pathways About
    1Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions0.36

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for RAB18
        Epithelial Tight Junctions



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RAB18
    Interactions:

        GeneGlobe Interaction Network for RAB18

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for RAB18 (Q9NP721, 3 ENSP000003494154) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP2R1AP301533, ENSP000003248044I2D: score=3 STRING: ENSP00000324804
    PPP2R1BP301543, ENSP000003113444I2D: score=3 STRING: ENSP00000311344
    TOM1L1O756743, ENSP000004089584I2D: score=3 STRING: ENSP00000408958
    CHMP243863, ENSP000003503864I2D: score=1 STRING: ENSP00000350386
    PDE6DO439243, ENSP000002876004I2D: score=4 STRING: ENSP00000287600
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001654eye development ISS--
    GO:0006184GTP catabolic process NAS10648831
    GO:0006886intracellular protein transport ----
    GO:0006897endocytosis ----
    GO:0006913nucleocytoplasmic transport ----

    Find genes that share ontologies with RAB18           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RAB18



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for RAB18 gene (5 alternative transcripts): 
    NM_001256410.1  NM_001256411.1  NM_001256412.1  NM_001256415.1  NM_021252.4  

    Unigene Cluster for RAB18:

    RAB18, member RAS oncogene family
    Hs.406799  [show with all ESTs]
    Unigene Representative Sequence: AB209698
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356940(uc001itv.3 uc001itw.3 uc010qdq.2 uc010qdr.2)
    ENST00000490236 ENST00000375802 ENST00000465772 ENST00000484281 ENST00000423465
    ENST00000535776
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RAB18 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RAB18 (see all 13):
    hsa-miR-3163 hsa-miR-455-5p hsa-miR-429 hsa-miR-338-5p hsa-miR-200c hsa-miR-4274 hsa-miR-19b hsa-miR-2276
    SwitchGear 3'UTR luciferase reporter plasmidRAB18 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RAB18
    Predesigned siRNA for gene silencing in human, mouse, rat RAB18
    Clone
    Products:
         
    OriGene clones in human, mouse for RAB18 (see all 7)
    OriGene ORF clones in mouse, rat for RAB18
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RAB18 (NM_021252)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAB18
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB18
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RAB18
    OriGene qSTAR qPCR primer pairs in human, mouse for RAB18
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RAB18
      QuantiTect SYBR Green Assays in human, mouse, rat RAB18
      QuantiFast Probe-based Assays in human, mouse, rat RAB18

    Additional mRNA sequence: 

    AB209698.1 AF087860.1 AF136974.1 AF137372.1 AF498950.1 AF532968.1 AK001555.1 AK090947.1 
    AK223153.1 AK295443.1 AK297629.1 AK299457.1 AL136734.1 AY574034.1 BC015014.2 BC029350.1 
    BT009840.1 CR533455.1 NR_046172.1 

    Selected DOTS entries (see all 26):

    DT.101985243  DT.100662115  DT.100662119  DT.318025  DT.412143  DT.92446118  DT.100662118  DT.206369 
    DT.95160609  DT.92446095  DT.92446098  DT.100741772  DT.102833242  DT.121240156  DT.121240182  DT.121240191 
    DT.121240230  DT.121240232  DT.121240303  DT.408113  DT.100662122  DT.100698239  DT.100720974  DT.121240209 

    Selected AceView cDNA sequences (see all 344):

    AI022502 BF197062 BQ015181 AA741560 F09812 BM463268 AU280411 CK725191 
    AI952095 AW008823 BM128820 AU130176 BM754867 AA127564 BM055207 BM129609 
    AF137372 BM678414 BU170221 AU076877 CB243921 AI245046 C02605 BE739077 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RAB18 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e · 9f
    SP1:                          -           -           -           -                                                               
    SP2:                          -           -           -     -     -                                                               
    SP3:                                      -           -     -     -                                                               
    SP4:                          -           -           -     -     -                 -     -                                       
    SP5:                          -           -           -     -     -                                                               


    ECgene alternative splicing isoforms for RAB18

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    RAB18 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RAB18 Expression
    About this image


    RAB18 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 17) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Neural Tube (Nervous System)
             Metencephalon
     
     Bone (Muscoskeletal System)
             Bone Marrow
    RAB18 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RAB18 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.406799

    UniProtKB/Swiss-Prot: RAB18_HUMAN, Q9NP72
    Tissue specificity: Ubiquitous

        Custom PCR Arrays for RAB18
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RAB18
    OriGene qSTAR qPCR primer pairs in human, mouse for RAB18
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RAB18
    QuantiTect SYBR Green Assays in human, mouse, rat RAB18
    QuantiFast Probe-based Assays in human, mouse, rat RAB18
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB18

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RAB18 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rab181 , 5 RAB18, member RAS oncogene family1, 5 94.01(n)1
    99.03(a)1
      18 (4.53 cM)5
    193301  NM_001278447.11  NP_001265376.11 
     67652055 
    chicken
    (Gallus gallus)
    Aves RAB181 RAB18, member RAS oncogene family 86.57(n)
    97.09(a)
      420483  NM_001006355.1  NP_001006355.1 
    lizard
    (Anolis carolinensis)
    Reptilia RAB186
    RAB18, member RAS oncogene family
    95(a)
    1 ↔ 1
    5(669192-686780)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.28422 Xenopus laevis, Similar to RAB18, member RAS oncogene more 81.8(n)    BC043996.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rab18b1 RAB18B, member RAS oncogene family 73.66(n)
    88.78(a)
      445055  NM_001003449.1  NP_001003449.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rab-RP43
    Rab181
    GTP binding3
    Rab181
    51(a)3
    54.38(n)1
    54.19(a)1
      5A113
    443601  NM_080005.31  NP_524744.21 
    worm
    (Caenorhabditis elegans)
    Secernentea rab-181 , 3 rab-181 72(a)3
    64.94(n)1
    72.99(a)1
      III(1151500-1152299)3
    1752721  NM_171081.41  NP_741092.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SEC46
    Rab family GTPase essential for vesicle-mediated e...
    40(a)
    1 → many
    VI(130334-130981) YFL005W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons RAB181 RAB18 60.98(n)
    62.5(a)
      840987  NM_103516.3  NP_175056.1 


    ENSEMBL Gene Tree for RAB18 (if available)
    TreeFam Gene Tree for RAB18 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for RAB18 gene
    RAB352  RAB33B2  RAB33A2  
    Selected SIMAP similar genes for RAB18 using alignment to 3 protein entries:     RAB18_HUMAN (see all proteins) (see all similar genes):
    rab1b    DKFZp686J06205    RAB17    RAB30    RAB8B    RAB43
    RAB15    RAB3A    RAB10    RAB2B    RAB11A    RAB19
    RAB7A    RAB13    RAB38    RAB8A    RAB3B    RAB7L1

    Find genes that share paralogs with RAB18           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for RAB18
    PGOHUM00000238395 PGOHUM00000238708 PGOHUM00000243734


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for RAB18 (see all 758)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0664954
    Warburg micro syndrome 3 (WARBM3)4--see VAR_0664952 L Q mis40--------
    rs760297141,2
    C--27525711(+) TTAAT-/AT/TA 
            
    TGTTA
    6 -- int10--------
    rs106550721,2
    C--27530889(+) TTTTT-/TTAAAGC 6 -- int1 trp30--------
    rs1459753051,2
    C--27533058(+) TGTAT-/AATT/ATT
    A
    /GTATATTA
    ATTCT
    6 -- int10--------
    rs2005821511,2
    --27539151(+) CATTG-/CTTCTTTC 6 -- int10--------
    rs722647161,2
    C--27539153(+) TTGCT-/TCTTTCT 6 -- int11Minor allele frequency- TC:0.50CSA 2
    rs724838581,2
    C--27541535(+) CGAGA-/CTCTGTC 6 -- int10--------
    rs38326571,2
    C--27547316(-) CATGCA/-CAATT 6 -- ut31 nc-transcript-variant1Minor allele frequency- -:0.00CSA 2
    rs1892575081,2
    --27697447(+) TGATAC/TTGCCA 6 -- us2k10--------
    rs1422636901,2
    C--27697479(+) TGCAA-/AGAGAT 6 -- us2k10--------

    HapMap Linkage Disequilibrium report for RAB18 (27793197 - 27831143 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for RAB18:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2734617CNV Deletion23290073
    esv2671913CNV Deletion23128226
    esv2734606CNV Deletion23290073
    nsv825319CNV Loss20364138
    nsv8614CNV Loss18304495

    Human Gene Mutation Database (HGMD): RAB18
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RAB18
    DNA2.0 Custom Variant and Variant Library Synthesis for RAB18

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 602207   
    OMIM disorders: 614222  
    UniProtKB/Swiss-Prot: RAB18_HUMAN, Q9NP72
  • Warburg micro syndrome 3 (WARBM3) [MIM:614222]: A rare syndrome characterized by microcephaly,
    microphthalmia, microcornia, congenital cataracts, optic atrophy, cortical dysplasia, in particular corpus
    callosum hypoplasia, severe mental retardation, spastic diplegia, and hypogonadism. Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • 9 diseases for RAB18:    
    About MalaCards
    warburg micro syndrome 3    warburg micro syndrome    micro syndrome    hormone producing pituitary cancer
    childhood medulloblastoma    large cell medulloblastoma    martsolf syndrome    warburg micro syndrome 1
    medulloblastoma

    2 diseases from the University of Copenhagen DISEASES database for RAB18:
    Large cell medulloblastoma     Hormone producing pituitary cancer

    Find genes that share disorders with RAB18           About GenesLikeMe


    Export disorders for RAB18 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for RAB18 gene, integrated from 10 sources (see all 42):
    (articles sorted by number of sources associating them with RAB18)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterisation of the human rab18 gene after stimulation of endothelial cells with histamine. (PubMed id 10648831)1, 2, 3 Schaefer U.... Neugebauer E. (FEBS Lett. 2000)
    2. Loss-of-function mutations in RAB18 cause Warburg micro syndrome. (PubMed id 21473985)1, 2 Bem D.... Aligianis I.A. (Am. J. Hum. Genet. 2011)
    3. Cloning and characterization of a novel splice variant of human Rab18 gene (RAB18). (PubMed id 16147880)1, 2 Dou T.... Mao Y. (DNA Seq. 2005)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    7. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    8. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    9. Mutation spectrum in RAB3GAP1, RAB3GAP2, and RAB18 and genotype-phenotype correlations in warburg micro syndrome and Martsolf syndrome. (PubMed id 23420520)1 Handley M.T....Aligianis I.A. (Hum. Mutat. 2013)
    10. Rab18 binds to hepatitis C virus NS5A and promotes interaction between sites of viral replication and lipid droplets. (PubMed id 23935497)1 Salloum S....Tai A.W. (PLoS Pathog. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 22931 HGNC: 14244 AceView: RAB18 Ensembl:ENSG00000099246 euGenes: HUgn22931
    ECgene: RAB18 H-InvDB: RAB18

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for RAB18 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAB18 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for RAB18 gene:
    Search GeneIP for patents involving RAB18

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for RAB18   OriGene RNAi products in human, mouse, rat for RAB18  
     OriGene qPCR primer pairs and template standards for RAB18   OriGene Protein Over-expression Lysate for RAB18  
     OriGene MassSpec something-or-other for RAB18   OriGene clones in human, mouse for RAB18  
     OriGene qSTAR qPCR primer pairs in human, mouse for RAB18   OriGene Purified Protein for RAB18  
     OriGene ORF clones in mouse, rat for RAB18   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RAB18   OriGene Custom Protein Services for RAB18  

     
     
     Block miRNA regulation of human, mouse, rat RAB18 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing RAB18
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RAB18 Predesigned siRNA for gene silencing in human, mouse, rat RAB18
     QuantiFast Probe-based Assays in human, mouse, rat RAB18 QuantiTect SYBR Green Assays in human, mouse, rat RAB18
     Custom PCR Arrays for RAB18 Search Chromatin IP Primers for RAB18
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RAB18  GeneGlobe Interaction Network for RAB18
     Regulatory tfbs in RAB18 promoter
     GenScript Custom Purified and Recombinant Proteins Services for RAB18 GenScript cDNA clones with any tag delivered in your preferred vector for RAB18
     GenScript Custom Assay Services for RAB18 GenScript Custom overexpressing Cell Line Services for RAB18
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for RAB18
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for RAB18
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     RAB18 antibodies
     RAB18 proteins
     RAB18 lysates
     Antibodies for RAB18
     See all of Abcam's Antibodies, Kits and Proteins for RAB18
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for RAB18
     Proteins for RAB18
     Antibodies for RAB18
     ELISAs for RAB18
     CLIAs for RAB18



     Browse ESI BIO Cell Lines and PureStem Progenitors for RAB18
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB18
     SwitchGear 3'UTR luciferase reporter plasmids for RAB18
     SwitchGear Promoter luciferase reporter plasmids for RAB18
     ThermoFisher Antibodies for RAB18
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB18
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RAB18
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RAB18
     LSBio Antibodies in human, mouse, rat for RAB18
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for RAB18
      Search eBioscience for proteins for RAB18
      Search eBioscience for elisas for RAB18
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RAB18 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4