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Aliases for RAB17 Gene

Aliases for RAB17 Gene

  • RAB17, Member RAS Oncogene Family 2 3 5

External Ids for RAB17 Gene

Previous GeneCards Identifiers for RAB17 Gene

  • GC02M236532
  • GC02M237164
  • GC02M238499
  • GC02M238769
  • GC02M238264
  • GC02M238147
  • GC02M230273

Summaries for RAB17 Gene

Entrez Gene Summary for RAB17 Gene

  • The Rab subfamily of small GTPases plays an important role in the regulation of membrane trafficking. RAB17 is an epithelial cell-specific GTPase (Lutcke et al., 1993 [PubMed 8486736]).[supplied by OMIM, Oct 2009]

GeneCards Summary for RAB17 Gene

RAB17 (RAB17, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB5C.

UniProtKB/Swiss-Prot for RAB17 Gene

  • The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Mainly observed in epithelial cells, transcytosis mediates for instance, the transcellular transport of immunoglobulins from the basolateral surface to the apical surface. Most probably controls membrane trafficking through apical recycling endosomes in a post-endocytic step of transcytosis. Required for melanosome transport and release from melanocytes, it also regulates dendrite and dendritic spine development (By similarity). May also play a role in cell migration.

Gene Wiki entry for RAB17 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB17 Gene

Genomics for RAB17 Gene

Regulatory Elements for RAB17 Gene

Promoters for RAB17 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RAB17 on UCSC Golden Path with GeneCards custom track

Genomic Location for RAB17 Gene

Chromosome:
2
Start:
237,574,322 bp from pter
End:
237,601,614 bp from pter
Size:
27,293 bases
Orientation:
Minus strand

Genomic View for RAB17 Gene

Genes around RAB17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB17 Gene

Proteins for RAB17 Gene

  • Protein details for RAB17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0T7-RAB17_HUMAN
    Recommended name:
    Ras-related protein Rab-17
    Protein Accession:
    Q9H0T7
    Secondary Accessions:
    • Q53QV6
    • Q6IA73
    • Q6PJZ0
    • Q9BVU1
    • Q9H9U9

    Protein attributes for RAB17 Gene

    Size:
    212 amino acids
    Molecular mass:
    23491 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RAB17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAB17 Gene

Proteomics data for RAB17 Gene at MOPED

Post-translational modifications for RAB17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB17 Gene

No data available for DME Specific Peptides for RAB17 Gene

Domains & Families for RAB17 Gene

Gene Families for RAB17 Gene

Suggested Antigen Peptide Sequences for RAB17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H0T7

UniProtKB/Swiss-Prot:

RAB17_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB17: view

Function for RAB17 Gene

Molecular function for RAB17 Gene

UniProtKB/Swiss-Prot Function:
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Mainly observed in epithelial cells, transcytosis mediates for instance, the transcellular transport of immunoglobulins from the basolateral surface to the apical surface. Most probably controls membrane trafficking through apical recycling endosomes in a post-endocytic step of transcytosis. Required for melanosome transport and release from melanocytes, it also regulates dendrite and dendritic spine development (By similarity). May also play a role in cell migration.
UniProtKB/Swiss-Prot Induction:
Up-regulated by forskolin probably through the transcription factor MITF.
genes like me logo Genes that share phenotypes with RAB17: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB17 Gene

Localization for RAB17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB17 Gene

Recycling endosome membrane; Lipid-anchor; Cytoplasmic side. Melanosome. Cell projection, dendrite. Note=May also localize at the basolateral and apical plasma membrane. In neurons, localizes to the cell body and dendritic shaft and spine. {ECO:0000250 UniProtKB:P35292}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB17 Gene COMPARTMENTS Subcellular localization image for RAB17 gene
Compartment Confidence
endosome 5
extracellular 5
plasma membrane 4
mitochondrion 3
cytosol 2

Gene Ontology (GO) - Cellular Components for RAB17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome IBA --
GO:0016020 membrane IEA --
GO:0016324 apical plasma membrane ISS --
GO:0030425 dendrite ISS --
GO:0042470 melanosome ISS --
genes like me logo Genes that share ontologies with RAB17: view

Pathways & Interactions for RAB17 Gene

genes like me logo Genes that share pathways with RAB17: view

Pathways by source for RAB17 Gene

1 Qiagen pathway for RAB17 Gene

Gene Ontology (GO) - Biological Process for RAB17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor ISS --
GO:0006886 intracellular protein transport IEA --
GO:0007165 signal transduction IEA --
GO:0032401 establishment of melanosome localization ISS --
GO:0032456 endocytic recycling ISS --
genes like me logo Genes that share ontologies with RAB17: view

No data available for SIGNOR curated interactions for RAB17 Gene

Drugs & Compounds for RAB17 Gene

No Compound Related Data Available

Transcripts for RAB17 Gene

Unigene Clusters for RAB17 Gene

RAB17, member RAS oncogene family:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB17 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f
SP1: - - - - -
SP2: - - - -
SP3: - - -
SP4: - - - -
SP5: - - -
SP6: - -
SP7:

Relevant External Links for RAB17 Gene

GeneLoc Exon Structure for
RAB17
ECgene alternative splicing isoforms for
RAB17

Expression for RAB17 Gene

mRNA expression in normal human tissues for RAB17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB17 Gene

This gene is overexpressed in Liver (x15.2) and Kidney - Cortex (x8.0).

Protein differential expression in normal tissues from HIPED for RAB17 Gene

This gene is overexpressed in Cervix (28.6), Fetal Brain (9.0), Urine (8.4), and Liver (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB17 Gene



SOURCE GeneReport for Unigene cluster for RAB17 Gene Hs.44278

mRNA Expression by UniProt/SwissProt for RAB17 Gene

Q9H0T7-RAB17_HUMAN
Tissue specificity: Expressed in melanocytes (at protein level).
genes like me logo Genes that share expression patterns with RAB17: view

Protein tissue co-expression partners for RAB17 Gene

Primer Products

In Situ Assay Products

Orthologs for RAB17 Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB17 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia RAB17 35
  • 81.13 (n)
  • 75.94 (a)
RAB17 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rab17 35
  • 77.99 (n)
  • 75.47 (a)
Rab17 16
Rab17 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RAB17 35
  • 98.89 (n)
  • 98.58 (a)
RAB17 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rab17 35
  • 79.15 (n)
  • 75.36 (a)
cow
(Bos Taurus)
Mammalia RAB17 36
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAB17 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 57 (a)
OneToMany
-- 36
  • 58 (a)
OneToMany
chicken
(Gallus gallus)
Aves RAB17 35
  • 64.09 (n)
  • 59.28 (a)
RAB17 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAB17 36
  • 52 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta chrw 36
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
OneToMany
Species with no ortholog for RAB17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RAB17 Gene

ENSEMBL:
Gene Tree for RAB17 (if available)
TreeFam:
Gene Tree for RAB17 (if available)

Paralogs for RAB17 Gene

genes like me logo Genes that share paralogs with RAB17: view

Variants for RAB17 Gene

Sequence variations from dbSNP and Humsavar for RAB17 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs2280289 - 237,575,086(+) CCCGT(A/G)GAGCC nc-transcript-variant, reference, synonymous-codon, missense
rs3751112 - 237,586,099(+) TGAAC(A/G)CACGG nc-transcript-variant, reference, missense
rs34311889 - 237,575,108(+) GTCGC(C/T)TCTCT nc-transcript-variant, reference, missense
rs6766 -- 237,574,521(-) TTTCC(A/G)CATCT nc-transcript-variant, utr-variant-3-prime
rs8184 -- 237,574,688(-) CCCCG(C/G)AGCAC nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RAB17 Gene

Variant ID Type Subtype PubMed ID
nsv876054 CNV Gain 21882294
nsv3229 CNV Loss 18451855
nsv876056 CNV Loss 21882294
esv28512 CNV Loss 19812545
nsv876057 CNV Gain 21882294

Variation tolerance for RAB17 Gene

Residual Variation Intolerance Score: 69.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.40; 63.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAB17 Gene

HapMap Linkage Disequilibrium report
RAB17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB17 Gene

Disorders for RAB17 Gene

Relevant External Links for RAB17

Genetic Association Database (GAD)
RAB17
Human Genome Epidemiology (HuGE) Navigator
RAB17
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAB17

No disorders were found for RAB17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB17 Gene

Publications for RAB17 Gene

  1. ERK2 drives tumour cell migration in three-dimensional microenvironments by suppressing expression of Rab17 and liprin- beta2. (PMID: 22328529) von Thun A. … Norman J.C. (J. Cell Sci. 2012) 3 4 67
  2. Rab17 localizes to recycling endosomes and regulates receptor-mediated transcytosis in epithelial cells. (PMID: 9624171) Hunziker W. … Peters P.J. (J. Biol. Chem. 1998) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Rab17-mediated recycling endosomes contribute to autophagosome formation in response to Group A Streptococcus invasion. (PMID: 25052408) Haobam B. … Nakagawa I. (Cell. Microbiol. 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for RAB17 Gene

Sources for RAB17 Gene

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