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Aliases for RAB17 Gene

Aliases for RAB17 Gene

  • RAB17, Member RAS Oncogene Family 2 3 5

External Ids for RAB17 Gene

Previous GeneCards Identifiers for RAB17 Gene

  • GC02M236532
  • GC02M237164
  • GC02M238499
  • GC02M238769
  • GC02M238264
  • GC02M238147
  • GC02M230273

Summaries for RAB17 Gene

Entrez Gene Summary for RAB17 Gene

  • The Rab subfamily of small GTPases plays an important role in the regulation of membrane trafficking. RAB17 is an epithelial cell-specific GTPase (Lutcke et al., 1993 [PubMed 8486736]).[supplied by OMIM, Oct 2009]

GeneCards Summary for RAB17 Gene

RAB17 (RAB17, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Metabolism of proteins. GO annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB5A.

UniProtKB/Swiss-Prot for RAB17 Gene

  • The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Mainly observed in epithelial cells, transcytosis mediates for instance, the transcellular transport of immunoglobulins from the basolateral surface to the apical surface. Most probably controls membrane trafficking through apical recycling endosomes in a post-endocytic step of transcytosis. Required for melanosome transport and release from melanocytes, it also regulates dendrite and dendritic spine development (By similarity). May also play a role in cell migration.

Gene Wiki entry for RAB17 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB17 Gene

Genomics for RAB17 Gene

Regulatory Elements for RAB17 Gene

Enhancers for RAB17 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F237574 1.1 Ensembl ENCODE 27.2 +26.2 26206 1.5 CTCF JUND MAZ TAF1 FOS CHD2 RAB17 ENSG00000222022 MLPH COL6A3 ENSG00000227107 PRLH LOC105373958
GH02F237581 0.9 Ensembl ENCODE 20.1 +19.5 19546 1.5 ZFP64 ARID4B THRB RAD21 RARA YY1 GLIS2 SCRT2 EGR2 HMG20B RAB17 MLPH LOC105373958 PRLH
GH02F237588 1.2 Ensembl ENCODE 13.8 +9.5 9529 7.8 PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF48 YY1 ZNF121 ELK1 FOS RAB17 PRLH RNU6-1140P MLPH LOC105373958 RAMP1 TRAF3IP1
GH02F237571 1 Ensembl ENCODE 12.3 +29.4 29370 1.4 MLX ZFP64 ARID4B ZNF48 ZNF2 SLC30A9 ZNF143 PAF1 ZNF263 MXD4 RAB17 ENSG00000222022 MLPH COL6A3 ILKAP PRLH LOC105373958
GH02F237639 0.5 ENCODE 11.6 -38.3 -38321 1.0 ZNF263 CHD4 CEBPB HNF4A EBF1 RAB17 LOC105373958 PRLH RNU6-1140P MLPH RBM44 LRRFIP1 PIR56300
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RAB17 on UCSC Golden Path with GeneCards custom track

Promoters for RAB17 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001834203 1314 201 ELF3 TBP MLX DMAP1 THRB ZNF48 ZSCAN9 RAD21 YY1 MIXL1

Genomic Location for RAB17 Gene

Chromosome:
2
Start:
237,574,322 bp from pter
End:
237,601,614 bp from pter
Size:
27,293 bases
Orientation:
Minus strand

Genomic View for RAB17 Gene

Genes around RAB17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB17 Gene

Proteins for RAB17 Gene

  • Protein details for RAB17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0T7-RAB17_HUMAN
    Recommended name:
    Ras-related protein Rab-17
    Protein Accession:
    Q9H0T7
    Secondary Accessions:
    • Q53QV6
    • Q6IA73
    • Q6PJZ0
    • Q9BVU1
    • Q9H9U9

    Protein attributes for RAB17 Gene

    Size:
    212 amino acids
    Molecular mass:
    23491 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RAB17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAB17 Gene

Post-translational modifications for RAB17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RAB17 Gene

Domains & Families for RAB17 Gene

Gene Families for RAB17 Gene

Protein Domains for RAB17 Gene

Suggested Antigen Peptide Sequences for RAB17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H0T7

UniProtKB/Swiss-Prot:

RAB17_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB17: view

Function for RAB17 Gene

Molecular function for RAB17 Gene

UniProtKB/Swiss-Prot Function:
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Mainly observed in epithelial cells, transcytosis mediates for instance, the transcellular transport of immunoglobulins from the basolateral surface to the apical surface. Most probably controls membrane trafficking through apical recycling endosomes in a post-endocytic step of transcytosis. Required for melanosome transport and release from melanocytes, it also regulates dendrite and dendritic spine development (By similarity). May also play a role in cell migration.
UniProtKB/Swiss-Prot Induction:
Up-regulated by forskolin probably through the transcription factor MITF.

Gene Ontology (GO) - Molecular Function for RAB17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IDA 17646400
GO:0005515 protein binding IPI 17646400
GO:0005525 GTP binding IEA --
GO:0019003 GDP binding IDA 20937701
genes like me logo Genes that share ontologies with RAB17: view
genes like me logo Genes that share phenotypes with RAB17: view

Animal Models for RAB17 Gene

MGI Knock Outs for RAB17:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RAB17

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RAB17 Gene

Localization for RAB17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB17 Gene

Recycling endosome membrane; Lipid-anchor; Cytoplasmic side. Melanosome. Cell projection, dendrite. Note=May also localize at the basolateral and apical plasma membrane. In neurons, localizes to the cell body and dendritic shaft and spine. {ECO:0000250 UniProtKB:P35292}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB17 Gene COMPARTMENTS Subcellular localization image for RAB17 gene
Compartment Confidence
endosome 5
extracellular 5
plasma membrane 4
mitochondrion 3
cytosol 2

Gene Ontology (GO) - Cellular Components for RAB17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA,IDA --
GO:0005768 endosome IEA --
GO:0005769 early endosome IBA --
GO:0005886 plasma membrane IBA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RAB17: view

Pathways & Interactions for RAB17 Gene

genes like me logo Genes that share pathways with RAB17: view

Pathways by source for RAB17 Gene

1 Qiagen pathway for RAB17 Gene

Gene Ontology (GO) - Biological Process for RAB17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor ISS --
GO:0006810 transport IEA --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0015031 protein transport IEA --
GO:0030100 regulation of endocytosis IBA --
genes like me logo Genes that share ontologies with RAB17: view

No data available for SIGNOR curated interactions for RAB17 Gene

Transcripts for RAB17 Gene

Unigene Clusters for RAB17 Gene

RAB17, member RAS oncogene family:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RAB17

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB17 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f
SP1: - - - - -
SP2: - - - -
SP3: - - -
SP4: - - - -
SP5: - - -
SP6: - -
SP7:

Relevant External Links for RAB17 Gene

GeneLoc Exon Structure for
RAB17
ECgene alternative splicing isoforms for
RAB17

Expression for RAB17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RAB17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB17 Gene

This gene is overexpressed in Liver (x15.2) and Kidney - Cortex (x8.0).

Protein differential expression in normal tissues from HIPED for RAB17 Gene

This gene is overexpressed in Cervix (28.6), Fetal Brain (9.0), Urine (8.4), and Liver (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RAB17 Gene



Protein tissue co-expression partners for RAB17 Gene

NURSA nuclear receptor signaling pathways regulating expression of RAB17 Gene:

RAB17

SOURCE GeneReport for Unigene cluster for RAB17 Gene:

Hs.44278

mRNA Expression by UniProt/SwissProt for RAB17 Gene:

Q9H0T7-RAB17_HUMAN
Tissue specificity: Expressed in melanocytes (at protein level).
genes like me logo Genes that share expression patterns with RAB17: view

Primer Products

Orthologs for RAB17 Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB17 34 35
  • 98.89 (n)
dog
(Canis familiaris)
Mammalia RAB17 34 35
  • 81.13 (n)
rat
(Rattus norvegicus)
Mammalia Rab17 34
  • 79.15 (n)
mouse
(Mus musculus)
Mammalia Rab17 34 16 35
  • 77.99 (n)
cow
(Bos Taurus)
Mammalia RAB17 35
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAB17 35
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 58 (a)
OneToMany
-- 35
  • 57 (a)
OneToMany
chicken
(Gallus gallus)
Aves RAB17 34 35
  • 64.09 (n)
lizard
(Anolis carolinensis)
Reptilia RAB17 35
  • 52 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta chrw 35
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 31 (a)
OneToMany
Species where no ortholog for RAB17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RAB17 Gene

ENSEMBL:
Gene Tree for RAB17 (if available)
TreeFam:
Gene Tree for RAB17 (if available)

Paralogs for RAB17 Gene

genes like me logo Genes that share paralogs with RAB17: view

Variants for RAB17 Gene

Sequence variations from dbSNP and Humsavar for RAB17 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10084167 -- 237,591,999(+) CCAGC(A/G)CTTTG nc-transcript-variant, upstream-variant-2KB
rs10164487 -- 237,578,249(+) AATGG(G/T)CTCAG intron-variant
rs10187545 -- 237,574,028(+) agccc(A/C)ataaa downstream-variant-500B
rs10190103 -- 237,573,993(+) ggccc(C/T)gtgca downstream-variant-500B
rs10195011 -- 237,585,676(+) TCTTC(C/T)GGGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB17 Gene

Variant ID Type Subtype PubMed ID
dgv4192n100 CNV loss 25217958
esv28512 CNV loss 19812545
nsv1000252 CNV loss 25217958
nsv1010093 CNV gain 25217958
nsv3229 CNV deletion 18451855

Variation tolerance for RAB17 Gene

Residual Variation Intolerance Score: 69.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.40; 63.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAB17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAB17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB17 Gene

Disorders for RAB17 Gene

Relevant External Links for RAB17

Genetic Association Database (GAD)
RAB17
Human Genome Epidemiology (HuGE) Navigator
RAB17
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAB17

No disorders were found for RAB17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB17 Gene

Publications for RAB17 Gene

  1. ERK2 drives tumour cell migration in three-dimensional microenvironments by suppressing expression of Rab17 and liprin- beta2. (PMID: 22328529) von Thun A. … Norman J.C. (J. Cell Sci. 2012) 3 4 64
  2. The recycling endosome protein Rab17 regulates melanocytic filopodia formation and melanosome trafficking. (PMID: 21291502) Beaumont K.A. … Stow J.L. (Traffic 2011) 3 4 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for RAB17 Gene

Sources for RAB17 Gene

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