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Aliases for RAB17 Gene

Aliases for RAB17 Gene

  • RAB17, Member RAS Oncogene Family 2 3 5

External Ids for RAB17 Gene

Previous GeneCards Identifiers for RAB17 Gene

  • GC02M236532
  • GC02M237164
  • GC02M238499
  • GC02M238769
  • GC02M238264
  • GC02M238147
  • GC02M230273

Summaries for RAB17 Gene

Entrez Gene Summary for RAB17 Gene

  • The Rab subfamily of small GTPases plays an important role in the regulation of membrane trafficking. RAB17 is an epithelial cell-specific GTPase (Lutcke et al., 1993 [PubMed 8486736]).[supplied by OMIM, Oct 2009]

GeneCards Summary for RAB17 Gene

RAB17 (RAB17, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are RAB geranylgeranylation and Metabolism of proteins. GO annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB5C.

UniProtKB/Swiss-Prot for RAB17 Gene

  • The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Mainly observed in epithelial cells, transcytosis mediates for instance, the transcellular transport of immunoglobulins from the basolateral surface to the apical surface. Most probably controls membrane trafficking through apical recycling endosomes in a post-endocytic step of transcytosis. Required for melanosome transport and release from melanocytes, it also regulates dendrite and dendritic spine development (By similarity). May also play a role in cell migration.

Gene Wiki entry for RAB17 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB17 Gene

Genomics for RAB17 Gene

Regulatory Elements for RAB17 Gene

Enhancers for RAB17 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G237581 1.4 Ensembl ENCODE dbSUPER 20.2 +19.5 19547 1.5 FOXA2 ZFP64 ARID4B THRB RAD21 RARA YY1 GLIS2 SCRT2 EGR2 RAB17 MLPH LOC105373958 PRLH
GH02G237574 0.9 ENCODE dbSUPER 27.2 +26.2 26206 1.5 CTCF MAZ JUND TAF1 FOS HNRNPL RBFOX2 CHD2 RAB17 ENSG00000222022 MLPH COL6A3 ENSG00000227107 PRLH LOC105373958
GH02G237588 1.5 Ensembl ENCODE dbSUPER 13.9 +9.5 9529 7.8 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF48 YY1 ZNF121 ELK1 RAB17 RNU6-1140P PRLH MLPH LOC105373958 RAMP1 TRAF3IP1
GH02G237685 1.8 FANTOM5 ENCODE dbSUPER 11.4 -90.8 -90770 13.1 HDGF PKNOX1 FOXA2 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 LRRFIP1 ILKAP RAB17 LOC105373958 PRLH RNU6-1140P RBM44 ESPNL UBE2F PIR56300
GH02G237508 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.6 +90.4 90379 5.4 PKNOX1 CREB3L1 ARNT ARID4B SIN3A ZNF2 ZNF766 ZNF143 KLF13 REST MLPH RNU6-1140P PRLH LOC105373958 RAB17 ENSG00000222022 COL6A3 MIR6811
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RAB17 on UCSC Golden Path with GeneCards custom track

Genomic Location for RAB17 Gene

Chromosome:
2
Start:
237,574,322 bp from pter
End:
237,601,614 bp from pter
Size:
27,293 bases
Orientation:
Minus strand

Genomic View for RAB17 Gene

Genes around RAB17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB17 Gene

Proteins for RAB17 Gene

  • Protein details for RAB17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0T7-RAB17_HUMAN
    Recommended name:
    Ras-related protein Rab-17
    Protein Accession:
    Q9H0T7
    Secondary Accessions:
    • Q53QV6
    • Q6IA73
    • Q6PJZ0
    • Q9BVU1
    • Q9H9U9

    Protein attributes for RAB17 Gene

    Size:
    212 amino acids
    Molecular mass:
    23491 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RAB17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAB17 Gene

Post-translational modifications for RAB17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RAB17 Gene

Domains & Families for RAB17 Gene

Gene Families for RAB17 Gene

Protein Domains for RAB17 Gene

Suggested Antigen Peptide Sequences for RAB17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H0T7

UniProtKB/Swiss-Prot:

RAB17_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB17: view

Function for RAB17 Gene

Molecular function for RAB17 Gene

UniProtKB/Swiss-Prot Function:
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Mainly observed in epithelial cells, transcytosis mediates for instance, the transcellular transport of immunoglobulins from the basolateral surface to the apical surface. Most probably controls membrane trafficking through apical recycling endosomes in a post-endocytic step of transcytosis. Required for melanosome transport and release from melanocytes, it also regulates dendrite and dendritic spine development (By similarity). May also play a role in cell migration.
UniProtKB/Swiss-Prot Induction:
Up-regulated by forskolin probably through the transcription factor MITF.

Gene Ontology (GO) - Molecular Function for RAB17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IDA 17646400
GO:0005515 protein binding IPI 17646400
GO:0005525 GTP binding IEA --
GO:0019003 GDP binding IDA 20937701
genes like me logo Genes that share ontologies with RAB17: view
genes like me logo Genes that share phenotypes with RAB17: view

Animal Models for RAB17 Gene

MGI Knock Outs for RAB17:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RAB17

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RAB17 Gene

Localization for RAB17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB17 Gene

Recycling endosome membrane; Lipid-anchor; Cytoplasmic side. Melanosome. Cell projection, dendrite. Note=May also localize at the basolateral and apical plasma membrane. In neurons, localizes to the cell body and dendritic shaft and spine. {ECO:0000250 UniProtKB:P35292}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB17 gene
Compartment Confidence
plasma membrane 5
extracellular 5
endosome 5
mitochondrion 3
cytosol 2
lysosome 1

Gene Ontology (GO) - Cellular Components for RAB17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA,IDA --
GO:0005768 endosome IEA --
GO:0005769 early endosome IBA --
GO:0005886 plasma membrane IBA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RAB17: view

Pathways & Interactions for RAB17 Gene

genes like me logo Genes that share pathways with RAB17: view

Pathways by source for RAB17 Gene

Gene Ontology (GO) - Biological Process for RAB17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor ISS --
GO:0006810 transport IEA --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0015031 protein transport IEA --
GO:0030100 regulation of endocytosis IBA --
genes like me logo Genes that share ontologies with RAB17: view

No data available for SIGNOR curated interactions for RAB17 Gene

Drugs & Compounds for RAB17 Gene

No Compound Related Data Available

Transcripts for RAB17 Gene

Unigene Clusters for RAB17 Gene

RAB17, member RAS oncogene family:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RAB17

Alternative Splicing Database (ASD) splice patterns (SP) for RAB17 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f
SP1: - - - - -
SP2: - - - -
SP3: - - -
SP4: - - - -
SP5: - - -
SP6: - -
SP7:

Relevant External Links for RAB17 Gene

GeneLoc Exon Structure for
RAB17
ECgene alternative splicing isoforms for
RAB17

Expression for RAB17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAB17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB17 Gene

This gene is overexpressed in Liver (x15.2) and Kidney - Cortex (x8.0).

Protein differential expression in normal tissues from HIPED for RAB17 Gene

This gene is overexpressed in Cervix (28.6), Fetal Brain (9.0), Urine (8.4), and Liver (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RAB17 Gene



Protein tissue co-expression partners for RAB17 Gene

NURSA nuclear receptor signaling pathways regulating expression of RAB17 Gene:

RAB17

SOURCE GeneReport for Unigene cluster for RAB17 Gene:

Hs.44278

mRNA Expression by UniProt/SwissProt for RAB17 Gene:

Q9H0T7-RAB17_HUMAN
Tissue specificity: Expressed in melanocytes (at protein level).

Evidence on tissue expression from TISSUES for RAB17 Gene

  • Liver(4.4)
  • Intestine(4.1)
  • Nervous system(4.1)
  • Eye(4)
  • Kidney(2)
genes like me logo Genes that share expression patterns with RAB17: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RAB17 Gene

Orthologs for RAB17 Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB17 34 35
  • 98.89 (n)
dog
(Canis familiaris)
Mammalia RAB17 34 35
  • 81.13 (n)
rat
(Rattus norvegicus)
Mammalia Rab17 34
  • 79.15 (n)
mouse
(Mus musculus)
Mammalia Rab17 34 16 35
  • 77.99 (n)
cow
(Bos Taurus)
Mammalia RAB17 35
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAB17 35
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 58 (a)
OneToMany
-- 35
  • 57 (a)
OneToMany
chicken
(Gallus gallus)
Aves RAB17 34 35
  • 64.09 (n)
lizard
(Anolis carolinensis)
Reptilia RAB17 35
  • 52 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta chrw 35
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 31 (a)
OneToMany
Species where no ortholog for RAB17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RAB17 Gene

ENSEMBL:
Gene Tree for RAB17 (if available)
TreeFam:
Gene Tree for RAB17 (if available)

Paralogs for RAB17 Gene

genes like me logo Genes that share paralogs with RAB17: view

Variants for RAB17 Gene

Sequence variations from dbSNP and Humsavar for RAB17 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000439438 -- 237,577,684(+) TCCCA(C/T)GCCTA intron-variant
rs1000756868 -- 237,589,718(+) TGTTA(C/T)TAGGT intron-variant, upstream-variant-2KB
rs1000831868 -- 237,590,367(+) AGCAC(A/G)CACAC intron-variant, upstream-variant-2KB
rs1000875399 -- 237,588,418(+) GCACA(A/G)ACAGA intron-variant
rs1001027725 -- 237,579,090(+) AGGAA(C/T)GTGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB17 Gene

Variant ID Type Subtype PubMed ID
dgv4192n100 CNV loss 25217958
esv28512 CNV loss 19812545
nsv1000252 CNV loss 25217958
nsv1010093 CNV gain 25217958
nsv3229 CNV deletion 18451855

Variation tolerance for RAB17 Gene

Residual Variation Intolerance Score: 69.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.40; 63.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAB17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAB17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB17 Gene

Disorders for RAB17 Gene

Relevant External Links for RAB17

Genetic Association Database (GAD)
RAB17
Human Genome Epidemiology (HuGE) Navigator
RAB17
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAB17

No disorders were found for RAB17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB17 Gene

Publications for RAB17 Gene

  1. ERK2 drives tumour cell migration in three-dimensional microenvironments by suppressing expression of Rab17 and liprin- beta2. (PMID: 22328529) von Thun A. … Norman J.C. (J. Cell Sci. 2012) 3 4 64
  2. The recycling endosome protein Rab17 regulates melanocytic filopodia formation and melanosome trafficking. (PMID: 21291502) Beaumont K.A. … Stow J.L. (Traffic 2011) 3 4 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for RAB17 Gene

  • Addgene plasmids for RAB17

Sources for RAB17 Gene

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