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Aliases for RAB17 Gene

Aliases for RAB17 Gene

  • RAB17, Member RAS Oncogene Family 2 3

External Ids for RAB17 Gene

Summaries for RAB17 Gene

Entrez Gene Summary for RAB17 Gene

  • The Rab subfamily of small GTPases plays an important role in the regulation of membrane trafficking. RAB17 is an epithelial cell-specific GTPase (Lutcke et al., 1993 [PubMed 8486736]).[supplied by OMIM, Oct 2009]

GeneCards Summary for RAB17 Gene

RAB17 (RAB17, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB5C.

UniProtKB/Swiss-Prot for RAB17 Gene

  • The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Mainly observed in epithelial cells, transcytosis mediates for instance, the transcellular transport of immunoglobulins from the basolateral surface to the apical surface. Most probably controls membrane trafficking through apical recycling endosomes in a post-endocytic step of transcytosis. Required for melanosome transport and release from melanocytes, it also regulates dendrite and dendritic spine development (By similarity). May also play a role in cell migration.

Gene Wiki entry for RAB17 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB17 Gene

Genomics for RAB17 Gene

Genomic Location for RAB17 Gene

Start:
237,574,322 bp from pter
End:
237,601,614 bp from pter
Size:
27,293 bases
Orientation:
Minus strand

Genomic View for RAB17 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAB17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB17 Gene

Regulatory Elements for RAB17 Gene

Proteins for RAB17 Gene

  • Protein details for RAB17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0T7-RAB17_HUMAN
    Recommended name:
    Ras-related protein Rab-17
    Protein Accession:
    Q9H0T7
    Secondary Accessions:
    • Q53QV6
    • Q6IA73
    • Q6PJZ0
    • Q9BVU1
    • Q9H9U9

    Protein attributes for RAB17 Gene

    Size:
    212 amino acids
    Molecular mass:
    23491 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RAB17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAB17 Gene

Proteomics data for RAB17 Gene at MOPED

Post-translational modifications for RAB17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB17 Gene

No data available for DME Specific Peptides for RAB17 Gene

Domains for RAB17 Gene

Gene Families for RAB17 Gene

HGNC:
  • RAB :RAB, member RAS oncogene

Suggested Antigen Peptide Sequences for RAB17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H0T7

UniProtKB/Swiss-Prot:

RAB17_HUMAN
Family:
  • Belongs to the small GTPase superfamily. Rab family.:
    • Q9H0T7
genes like me logo Genes that share domains with RAB17: view

Function for RAB17 Gene

Molecular function for RAB17 Gene

UniProtKB/Swiss-Prot Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Mainly observed in epithelial cells, transcytosis mediates for instance, the transcellular transport of immunoglobulins from the basolateral surface to the apical surface. Most probably controls membrane trafficking through apical recycling endosomes in a post-endocytic step of transcytosis. Required for melanosome transport and release from melanocytes, it also regulates dendrite and dendritic spine development (By similarity). May also play a role in cell migration.
UniProtKB/Swiss-Prot Induction: Up-regulated by forskolin probably through the transcription factor MITF.

Gene Ontology (GO) - Molecular Function for RAB17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IDA 17646400
GO:0005515 protein binding IPI 17646400
GO:0005525 GTP binding IEA --
GO:0019003 GDP binding IDA 20937701
genes like me logo Genes that share ontologies with RAB17: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RAB17 Gene

Localization for RAB17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB17 Gene

Recycling endosome membrane; Lipid-anchor; Cytoplasmic side. Cell projection, dendrite. Note=May also localize at the basolateral and apical plasma membrane. In neurons, localizes to the cell body and dendritic shaft and spine (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB17 Gene COMPARTMENTS Subcellular localization image for RAB17 gene
Compartment Confidence
endosome 5
plasma membrane 4
mitochondrion 3
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for RAB17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005634 nucleus --
GO:0005737 cytoplasm --
GO:0005769 early endosome IBA --
GO:0005886 plasma membrane IBA --
genes like me logo Genes that share ontologies with RAB17: view

Pathways for RAB17 Gene

genes like me logo Genes that share pathways with RAB17: view

Pathways by source for RAB17 Gene

1 Qiagen pathway for RAB17 Gene

Gene Ontology (GO) - Biological Process for RAB17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor ISS --
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport IBA --
GO:0006913 nucleocytoplasmic transport --
GO:0007165 signal transduction --
genes like me logo Genes that share ontologies with RAB17: view

Transcripts for RAB17 Gene

Unigene Clusters for RAB17 Gene

RAB17, member RAS oncogene family:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAB17 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f
SP1: - - - - -
SP2: - - - -
SP3: - - -
SP4: - - - -
SP5: - - -
SP6: - -
SP7:

Relevant External Links for RAB17 Gene

GeneLoc Exon Structure for
RAB17
ECgene alternative splicing isoforms for
RAB17

Expression for RAB17 Gene

mRNA expression in normal human tissues for RAB17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB17 Gene

This gene is overexpressed in Liver (15.2) and Kidney - Cortex (8.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB17 Gene

SOURCE GeneReport for Unigene cluster for RAB17 Gene Hs.44278

mRNA Expression by UniProt/SwissProt for RAB17 Gene

Q9H0T7-RAB17_HUMAN
Tissue specificity: Expressed in melanocytes (at protein level).
genes like me logo Genes that share expressions with RAB17: view

Orthologs for RAB17 Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB17 35
  • 98.89 (n)
  • 98.58 (a)
RAB17 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RAB17 36
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAB17 35
  • 81.13 (n)
  • 75.94 (a)
RAB17 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rab17 35
  • 77.99 (n)
  • 75.47 (a)
Rab17 16
Rab17 36
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAB17 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 57 (a)
OneToMany
-- 36
  • 58 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Rab17 35
  • 79.15 (n)
  • 75.36 (a)
chicken
(Gallus gallus)
Aves RAB17 35
  • 64.09 (n)
  • 59.28 (a)
RAB17 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAB17 36
  • 52 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta chrw 36
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
OneToMany
Species with no ortholog for RAB17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RAB17 Gene

ENSEMBL:
Gene Tree for RAB17 (if available)
TreeFam:
Gene Tree for RAB17 (if available)

Paralogs for RAB17 Gene

genes like me logo Genes that share paralogs with RAB17: view

Variants for RAB17 Gene

Sequence variations from dbSNP and Humsavar for RAB17 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs6766 -- 237,574,521(-) TTTCC(A/G)CATCT utr-variant-3-prime, nc-transcript-variant
rs8184 -- 237,574,688(-) CCCCG(C/G)AGCAC utr-variant-3-prime, nc-transcript-variant
rs14709 -- 237,574,497(+) CCCTT(C/T)CCAGG utr-variant-3-prime, nc-transcript-variant
rs1047724 -- 237,574,564(-) AGGAA(A/G)AAATG utr-variant-3-prime, nc-transcript-variant
rs1047791 -- 237,574,401(-) AGATT(C/T)TGAGA utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB17 Gene

Variant ID Type Subtype PubMed ID
nsv876054 CNV Gain 21882294
nsv3229 CNV Loss 18451855
nsv876056 CNV Loss 21882294
esv28512 CNV Loss 19812545
nsv876057 CNV Gain 21882294

Relevant External Links for RAB17 Gene

HapMap Linkage Disequilibrium report
RAB17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB17 Gene

Disorders for RAB17 Gene

(1) University of Copenhagen DISEASES for RAB17 Gene

Relevant External Links for RAB17

Genetic Association Database (GAD)
RAB17
Human Genome Epidemiology (HuGE) Navigator
RAB17
genes like me logo Genes that share disorders with RAB17: view

No data available for UniProtKB/Swiss-Prot for RAB17 Gene

Publications for RAB17 Gene

  1. Rab17 localizes to recycling endosomes and regulates receptor-mediated transcytosis in epithelial cells. (PMID: 9624171) Hunziker W. … Peters P.J. (J. Biol. Chem. 1998) 2 3
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The recycling endosome protein Rab17 regulates melanocytic filopodia formation and melanosome trafficking. (PMID: 21291502) Beaumont K.A. … Stow J.L. (Traffic 2011) 3 4

Products for RAB17 Gene

  • Addgene plasmids for RAB17

Sources for RAB17 Gene

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