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RAB17 Gene

protein-coding   GIFtS: 54

GC02M238147
RAB17, member RAS oncogene family
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
FLJ12538 2
Descriptions
RAB17, member RAS oncogene family 2
External Ids
HGNC: 165231
Entrez Gene: 642842
UniProtKB: Q9H0T73
Ensembl: ENSG000001248397
Search outside databases for aliases for RAB17 gene

Previous GC identifers: GC02M236532 GC02M237164 GC02M238499 GC02M238769 GC02M238264

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: RAB17_HUMAN, Q9H0T7
Function: Might be involved in transcellular transport (By similarity)

Gene Wiki entry for RAB17

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the RAB17 gene  

Entrez Gene cytogenetic band: 2q37.3   Ensembl cytogenetic band:  2q37.3   HGNC cytogenetic band: 2q37.3

RAB17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M238147:     (about GC identifiers)

Start:
238,147,704 bp from pter
End:
238,353,276 bp from pter
Size:
205,573 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000002.10  NT_005120.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: RAB17_HUMAN, Q9H0T7 (See protein sequence)
Recommended Name: Ras-related protein Rab-17  
Size: 212 amino acids; 23491 Da
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
Secondary accessions: Q53QV6 Q6IA73 Q9BVU1 Q9H9U9

REFSEQ proteins: NP_071894.1  

ENSEMBL proteins: 
ENSP00000386792 ENSP00000375858 ENSP00000264601 ENSP00000386589 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (Rab17)
Human Recombinant Proteins from Abnova (RAB17)
              OriGene Purified Recombinant Human Protein: RAB17 

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005622 intracellular IDA11256614
GO:0005886 plasma membrane IEA--
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Antibodies for RAB17: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for RAB17
Browse R&D Systems for Antibodies
Antibodies from Abcam (Rab17), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (RAB17)
Novus Biologicals Antibodies for RAB17

Assays for RAB17: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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4 InterPro domains/families:
 IPR001806 Ras_GTPase
 IPR005225 Small_GTP_bd
 IPR003579 GTPase_Rab
 IPR013753 Ras


   GeneDecks  RAB17 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q9H0T7

ProtoNet protein and cluster: Q9H0T7

1 Blocks protein family: IPB001806 Transforming protein P21 RAS signature

UniProtKB/Swiss-Prot: RAB17_HUMAN, Q9H0T7
Similarity: Belongs to the small GTPase superfamily. Rab family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (RAB17)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (RAB17)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_022449

              Applied Biosystems Silencer® siRNAs for RAB17

              Sigma-Aldrich siRNA for RAB17  
                     Sigma-Aldrich shRNA for RAB17  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for RAB17
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_022449
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_022449
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_022449 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_022449

UniProtKB/Swiss-Prot: RAB17_HUMAN, Q9H0T7
Function: Might be involved in transcellular transport (By similarity)

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0000166 nucleotide binding IEA--
GO:0005515 protein binding IPI17353931
GO:0005525 GTP binding IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section



5/6 Interacting proteins for RAB17 (ENSP000002646013 Q9H0T71, 2) via UniProtKB, MINT, and/or STRING (see all 6 )
InteractantInteraction Details
GeneCardExternal ID(s)
CHMP6Q96FZ71EBI-721615, EBI-1049648
NUDT3O959892MINT-63333
S100A8P051092MINT-63399
RABAC1ENSP000002220083STRING (score=.866)
CSNK2A1PENSP000003714003STRING (score=.834)
About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA--
GO:0015031 protein transport IEA--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for RAB17
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for RAB17

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (RAB17)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (RAB17)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_022449

              Sigma-Aldrich siRNA for RAB17  
                     Sigma-Aldrich shRNA for RAB17  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_022449  

REFSEQ mRNAs for RAB17 gene: 

NM_022449.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_022449  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_022449
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_022449
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_022449 

Additional cDNA sequence: 

AK022600.1 AK225423.1 AL136645.1 BC000929.2 BC007907.2 BC009827.2 BC023661.2 BC050426.1 
BX647412.1 CR457282.1 CR533454.1 CR591120.1 CR600396.1 CR606784.1 CR608634.1 CR621894.1 
CR624533.1 CR626220.1 

8 DOTS entries:

DT.445338  DT.120934537  DT.97843061  DT.100657336  DT.95368759  DT.100657337  DT.100657637  DT.95282591 

24/160 AceView cDNA sequences (see all 160 ):

CB137770 BI759255 CR600396 AW009045 BU160968 AL548167 CB135219 BF477737 
AK022600 CB141213 AI206424 NM_022449 AA913129 AI927566 BU956864 BC023661 
AI783777 CK430084 CR621894 CB135611 CR606784 BQ920683 BU739652 CA391377 

highest scoring ESTs for RAB17:

AA418063 AI904602 AK022600 AL136645 AL543811 AL548167 AL553872 AU124658 BC007907 BC009827 

Unigene Cluster for RAB17:

RAB17, member RAS oncogene family
Hs.708264  [show with all ESTs]
Unigene Representative Sequence: BX647412


GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for RAB17 (see all 7 )

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f
SP1:                    -     -     -                 -     -                                             
SP2:                          -     -                 -     -                                             
SP3:                                -                 -     -                                             
SP4:                                -     -           -     -                                             
SP5:                    -     -     -                                                                     

About this scheme

ECgene alternative splicing isoforms for RAB17

4 Ensembl transcripts including schematic representations:
ENST00000409576  ENST00000392001  ENST00000264601  ENST00000409822  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

RAB17 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for RAB17

1 / 2 / 3

3 probe-sets matching RAB17 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
52119_at2, 3 U95-B 1 1.00 1.00 1.00 1.00 AA418063 0.80 1.00 0.91 1

218931_at2, 3 U133-A 1 1.00 1.00 -- -- NM_022449 0.60 1.00 0.82 1

218931_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  RAB17 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: GTCTCCCGGC

SOURCE GeneReport for Unigene cluster: Hs.708264
(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for RAB17 gene from 4 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
RAB171   -- RAB17, member RAS oncogene family 81.2(n)
76.3(a)
607120  XM_843712.1  XP_848805.1 
rat
(Rattus norvegicus)
Rab171   -- RAB17, member RAS oncogene family 80.43(n)
77.72(a)
503269  XM_578804.2  XP_578804.2 
mouse
(Mus musculus)
Rab171, 5 1 (57.90 cM)5
RAB17, member RAS oncogene family1, 5 78.04(n)1
75.83(a)1
193291  NM_008998.31  NP_033024.11 
 AB2326115  AI5916335  (see all 14)
chicken
(Gallus gallus)
RAB171   -- RAB17, member RAS oncogene family 64.09(n)
59.28(a)
424017  XM_421874.2  XP_421874.2 
About this table        Species with no ortholog for RAB17

ENSEMBL Gene Tree for RAB17
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for RAB17 gene
RAB5C2  RAB5A2  RAB5B2  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/285 NCBI SNPs in RAB17 are shown (see all 285 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 117)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 2 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs67661,2
A,C,F,H,O238147903(-) TTTCCA/GCATCT 1 -- ut31 ese315Minor allele frequency- G:0.45MN EA NA EU WA 2928
rs22802881,2
A,C,F,H238148214(+) CCATGT/CGACGC 1 -- ut31 ese312Minor allele frequency- C:0.42EA EU WA NA 2464
rs46632621,2
A,C,F,H238178578(+) gctctG/Acagag 1 -- ng318Minor allele frequency- A:0.17EU EA WA 838
rs75802581,2
A,C,F,H238178059(+) AGGACG/AGTCCA 1 -- ng318Minor allele frequency- A:0.28EU EA WA 828
--
rs101901031,2
A,C,F,H238147375(+) ggcccT/Cgtgca 1 -- ng518Minor allele frequency- C:0.06EU EA WA 840
rs22928731,2
C,F,H238164183(-) CTCCCG/AGGTCA 1 -- ut51 ese38Minor allele frequency- A:0.12EA NA EU WA 1824
rs22928721,2
C,F,H238164273(-) ACCCCG/AGAATA 1 -- ut51 ese37Minor allele frequency- A:0.19EA NA EU 1922
rs37511121,2
C,F,H238159481(+) TGAACA/GCACGG 1 V/A mis19Minor allele frequency- G:0.27EU EA WA NA 904
rs22928711,2
C,F,H238164429(-) GCTTCC/TAGCTG 1 -- ut51 ese39Minor allele frequency- N:0.00EA NA EU WA 1338
rs81841,2
A,C,F238148070(-) CCCCGC/GAGCAC 1 -- ut314Minor allele frequency- G:0.21MN NA 326
About this table

HapMap Linkage Disequilibrium images for RAB17 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 602206

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/17 PubMed articles for RAB17 gene (see all 17 ):
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 64284 HGNC: 16523 AceView: RAB17 Ensembl:ENSG00000124839 euGenes: HUgn64284
ECgene: RAB17 H-InvDB: RAB17
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

NameDescription
ATLAS Chromosomes in Cancer entry for RAB17 Genetics and Cytogenetics in Oncology and Haematology
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for RAB17:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
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 Predesigned and custom siRNAs for RAB17 Antibodies for RAB17
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for RAB17 Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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 Recombinant Proteins
(Rab17)
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 Tagged/untagged cDNA clones
 Validated SYBR primer pairs
 Purified proteins from HEK293T cells
 Western blot validated antibodies
 shRNA in GFP-retroviral vector
 Search Tocris compounds for RAB17




 Drugs for RAB17
 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for RAB17

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