RAB15 Gene
protein-coding GIFtS : 51
GCID: GC14 M065412
RAB15, member RAS oncogene family
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Aliasesfor RAB15 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases RAB15, Member RAS Oncogene Family 1 2 RAB15, Member RAS Onocogene Family2 Ras-Related Protein Rab-152 Ras-Related Protein Rab-15 Isoform AN12 Ras-Related Protein Rab-15 Isoform AN22 Ras-Related Protein Rab-15 Isoform AN32
Export aliases for RAB15 gene to outside databases Previous GC identifers: GC14M059207 GC14M063402 GC14M064482 GC14M045582
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Summariesfor RAB15 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: RAB15_HUMAN, P59190 Function : May act in concert with RAB3A in regulating aspects of synaptic vesicle membrane flow within the nerveterminal (By similarity) Gene Wiki entry for RAB15
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Genomic Viewsfor RAB15 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000014.8 NC_018925.1 NT_026437.12 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the RAB15 gene promoter: C/EBPbeta RFX1 USF1 FOXF2 Nkx2-2 Arnt PPAR-gamma1 USF-1 PPAR-gamma2 Pax-4a Other transcription factors Search SABiosciences Chromatin IP Primers for RAB15 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat RAB15
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 14q23.3 Ensembl cytogenetic band: 14q23.3 HGNC cytogenetic band: 14q23.2 RAB15 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 14 GeneLoc Exon Structure
GeneLoc location for GC14M065412: view genomic region
(about GC identifiers )
Start:
65,412,532 bp from pter
End:
65,439,494 bp from pter
Size:
26,963 bases
Orientation:
minus strand
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Proteinsfor RAB15 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: RAB15_HUMAN, P59190 (See
protein sequence )Recommended Name: Ras-related protein Rab-15 Size : 212 amino acids; 24391 Da
Subunit : The GTP bound form of RAB15 interacts with REP15
Subcellular location : Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
Secondary accessions : Q86TX7 Q8IW89Alternative splicing : 2 isoforms : P59190-1 P59190-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for RAB15: NX_P59190 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P59190 RAB15 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_941959.1 ENSEMBL proteins: ENSP00000267512 ENSP00000434103 ENSP00000464662 ENSP00000433485 ENSP00000452195 ENSP00000463773 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005886 plasma membrane
IEA --
RAB15 for ontologies About GeneDecksing RAB15 Antibody Products: Assay Products for RAB15:
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Protein
Domains / Familiesfor RAB15 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
RAB15 for domains About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P59190 ProtoNet protein and cluster: P59190
4 Blocks protein families : IPB001806 Transforming protein P21 RAS signature IPB002041 GTP-binding nuclear protein Ran IPB003577 Ras small GTPase IPB003578 Ras small GTPase UniProtKB/Swiss-Prot: RAB15_HUMAN, P59190 Similarity : Belongs to the small GTPase superfamily. Rab family
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Functionfor RAB15 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: RAB15_HUMAN, P59190 Function : May act in concert with RAB3A in regulating aspects of synaptic vesicle membrane flow within the nerveterminal (By similarity)
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for RAB15 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for RAB15OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: RAB15 (NM_198686 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RAB15 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RAB15
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB15
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005525 GTP binding
IEA --
RAB15 for ontologies About GeneDecksing 1 GenomeRNAi human phenotype for RAB15 :
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Pathways & Interactionsfor RAB15 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways   About this table See pathways by source Super-pathway contained gene-specific pathways 1 Sertoli-Sertoli Cell Junction Dynamics
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RAB15 Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAB15 STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)5/8 Interacting proteins for RAB15 (P59190 3 ENSP00000267512 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 8 )About this table Gene Ontology (GO): 2 biological process terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0007264 small GTPase mediated signal transduction
IEA -- GO:0015031 protein transport
IEA --
RAB15 for ontologies About GeneDecksing
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Drugs & Compoundsfor RAB15 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for RAB15 1 HMDB Compound for RAB15 About this table Search CenterWatch for drugs/clinical trials and news about RAB15
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Transcriptsfor RAB15 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for RAB15 gene: NM_198686.2 Unigene Cluster for RAB15:
RAB15, member RAS oncogene family Hs.512492 [show with all ESTs ] Unigene Representative Sequence: NM_198686 7 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000267512 (uc001xhz.2 uc021rur.1 uc021rus.1 uc021rut.1 )ENST00000533601 ENST00000585059 ENST00000426039 ENST00000554593 ENST00000555256 ENST00000436278 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for RAB15 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for RAB15OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: RAB15 (NM_198686 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RAB15 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RAB15
Additional cDNA sequence: AB672631.2 AB672632.1 AB678452.1 AB678453.1 BC014511.1 BC040679.2 BX248046.1 BX640825.1
10 DOTS entries : DT.91655154 DT.100715880
DT.454380 DT.92426949 DT.100790904 DT.100714529 DT.97816418 DT.100715879 DT.95242640 DT.95257083 24/120 AceView cDNA sequences (see all 120 ):
BG057625 CA424721 BM128186 CB044182 AW027845 BX248046 BX119534 CK300190 BX647017 BM975016 AI554311 BX397019 BM551913 CB158366 BX093757 BG766350 BQ188717 CA411919 BM049329 AW662473 BG676934 BX479105 BG760915 NM_198686 GeneLoc Exon Structure 4 Alternative Splicing Database (ASD) splice patterns (SP) for RAB15 About this scheme ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c SP1 :             -   -               SP2 :     -         -   -               SP3 :     -           -               SP4 :                            
ECgene alternative splicing isoforms for RAB15
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Expression for RAB15 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section RAB15 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TCTTGAGGCC
About this image RAB15 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See RAB15 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for RAB15 SOURCE GeneReport for Unigene cluster: Hs.512492 SABiosciences Custom PCR Arrays for RAB15 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for RAB15Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse / rat RAB15 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat RAB15 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat RAB15 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB15
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Orthologsfor RAB15 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for RAB15 gene from 3/6 species (see all 6 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
mouse (Mus musculus)
Mammalia
Rab155
RAB15, member RAS oncogene family
--
 
12 (33.73 cM) 76797960
lizard (Anolis carolinensis)
Reptilia
--
--
65(a)
1 ↔ 1
GL344688.1(1568-11726)
honey bee (Apis mellifera)
Insecta
--
--
29(a)
1 ↔ 1
GroupUn.1604(3049-3357)
ENSEMBL Gene Tree for RAB15 (if available)TreeFam Gene Tree for RAB15 (if available)
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Paralogsfor RAB15 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor RAB15 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 14 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for RAB15 (65412532 - 65439494 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 5 variations for RAB15 5 CNVs : 7038 76660 87249 76661 66653
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing RAB15
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Disorders
/ Diseasesfor RAB15 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
RAB15 for disorders About GeneDecksing 3 diseases for RAB15 : About MalaCards differentiating neuroblastoma pulmonary disease neuroblastoma Human Genome Epidemiology (HuGE) Navigator: RAB15 (9 documents) Export disorders for RAB15 gene to outside databases
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Publicationsfor RAB15 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for RAB15 gene, integrated from 9 sources (see all 24 ): (articles sorted by number of sources associating them with RAB15) Utopia : connect your pdf to the dynamic world of online information
Rab15 effector protein: a novel protein for receptor recycling from the endocytic recycling compartment. (PubMed id 16195351) 1 , 2 Strick D.J. and Elferink L.A. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121) 1 , 2 Heilig R.... Weissenbach J. (2003) Evolution of the Rab family of small GTP-binding proteins. (PubMed id 11697911) 1 , 3 Pereira-Leal J.B. and Seabra M.C. (2001) Shotgun proteomics and network analysis of ubiquitin-r elated proteins from human breast carcinoma epithelial cells. (PubMed id 21853274) 1 Zhou J....Liang S. (2012) Rab15 alternative splicing is altered in spheres of ne uroblastoma cells. (PubMed id 22427180) 1 Pham T.V....Nishimura N. (2012) An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. (PubMed id 21319273) 1 Neganova I....Lako M. (2011) Initial characterization of the human central proteome. (PubMed id 21269460) 2 Burkard T.R.... Colinge J. (2011) Rab15 expression correlates with retinoic acid-induce d differentiation of neuroblastoma cells. (PubMed id 21491086) 1 Nishimura N....Matsuo M. (2011) Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168) 1 Guey L.T....Malats N. (2010)
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External Searches for RAB15 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing RAB15 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing RAB15 gene
(According to HUGE )
About This Section --
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Specialized Databases showing RAB15 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for RAB15 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for RAB15 gene: Search GeneIP for patents involving RAB15 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor RAB15 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for RAB15 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for RAB15 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for RAB15 OriGene Protein Over-expression Lysate for RAB15 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for RAB15 OriGene 3'-UTR Clone for RAB15 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for RAB15 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for RAB15 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for RAB15 OriGene Custom Protein Services for RAB15 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RAB15 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing RAB15 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat RAB15 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat RAB15 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat RAB15 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat RAB15
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RAB15 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB15
Search ThermoFisher Antibodies for RAB15
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RAB15
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Aliases for RAB15
Databases for RAB15
Disorders / Diseases for RAB15
Domains / Families for RAB15
Drugs / Compounds for RAB15
Expression for RAB15
Function for RAB15
Genomic Views for RAB15
Intellectual Property for RAB15
Orthologs for RAB15
Paralogs for RAB15
Pathways / Interactions for RAB15
Products for RAB15
Proteins for RAB15
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Search Box for RAB15
Summaries for RAB15
Transcripts for RAB15
Variants for RAB15
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