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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RAB15 Gene

protein-coding   GIFtS: 51
GCID: GC14M065412

RAB15, member RAS oncogene family

 Explore 3 diseases affiliated with
RAB15 via our new
 Human Malady Compendium 
Biological research products
for RAB15
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
RAB15, Member RAS Oncogene Family1 2
RAB15, Member RAS Onocogene Family2
Ras-Related Protein Rab-152
Ras-Related Protein Rab-15 Isoform AN12
Ras-Related Protein Rab-15 Isoform AN22
Ras-Related Protein Rab-15 Isoform AN32

External Ids:    HGNC: 201501   Entrez Gene: 3762672   Ensembl: ENSG000001399987   UniProtKB: P591903   

Export aliases for RAB15 gene to outside databases

Previous GC identifers: GC14M059207 GC14M063402 GC14M064482 GC14M045582


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: RAB15_HUMAN, P59190
Function: May act in concert with RAB3A in regulating aspects of synaptic vesicle membrane flow within the nerve
terminal (By similarity)

Gene Wiki entry for RAB15


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RAB15 gene promoter:
         C/EBPbeta   RFX1   USF1   FOXF2   Nkx2-2   Arnt   PPAR-gamma1   USF-1   PPAR-gamma2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRAB15 promoter sequence
   Search SABiosciences Chromatin IP Primers for RAB15

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q23.3   Ensembl cytogenetic band:  14q23.3   HGNC cytogenetic band: 14q23.2

RAB15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAB15 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M065412:  view genomic region     (about GC identifiers)

Start:
65,412,532 bp from pter      End:
65,439,494 bp from pter
Size:
26,963 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RAB15_HUMAN, P59190 (See protein sequence)
Recommended Name: Ras-related protein Rab-15  
Size: 212 amino acids; 24391 Da
Subunit: The GTP bound form of RAB15 interacts with REP15
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
Secondary accessions: Q86TX7 Q8IW89
Alternative splicing: 2 isoforms:  P59190-1   P59190-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RAB15: NX_P59190

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P59190

  • RAB15 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_941959.1  
    ENSEMBL proteins: 
     ENSP00000267512   ENSP00000434103   ENSP00000464662   ENSP00000433485   ENSP00000452195  
     ENSP00000463773  

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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RAB15

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--


    RAB15 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for RAB15


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    RAB15 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR003579 Small_GTPase_Rab_type

    Graphical View of Domain Structure for InterPro Entry P59190

    ProtoNet protein and cluster: P59190

    4 Blocks protein families:
    IPB001806 Transforming protein P21 RAS signature
    IPB002041 GTP-binding nuclear protein Ran
    IPB003577 Ras small GTPase
    IPB003578 Ras small GTPase


    UniProtKB/Swiss-Prot: RAB15_HUMAN, P59190
    Similarity: Belongs to the small GTPase superfamily. Rab family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: RAB15_HUMAN, P59190
    Function: May act in concert with RAB3A in regulating aspects of synaptic vesicle membrane flow within the nerve
    terminal (By similarity)

    miRNA
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    hsa-miR-3164 hsa-let-7d hsa-miR-513a-5p hsa-miR-128 hsa-miR-29a hsa-miR-30d hsa-miR-766 hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidRAB15 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAB15 (see all 7)
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB15

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005525GTP binding IEA--


    RAB15 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for RAB15:
     Small cells 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions0.36

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RAB15
        Epithelial Tight Junctions


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAB15

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5/8 Interacting proteins for RAB15 (P591903 ENSP000002675124) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RABIFP472243, ENSP000003562314I2D: score=3 STRING: ENSP00000356231
    RPH3AQ9Y2J03, ENSP000004132544I2D: score=2 STRING: ENSP00000413254
    ATG5Q9H1Y03I2D: score=1 
    CLN3Q132863I2D: score=1 
    GABARAPL1Q9H0R83I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0015031protein transport IEA--


    RAB15 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RAB15

    1 HMDB Compound for RAB15    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    Search CenterWatch for drugs/clinical trials and news about RAB15 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RAB15 gene: 
    NM_198686.2  

    Unigene Cluster for RAB15:

    RAB15, member RAS oncogene family
    Hs.512492  [show with all ESTs]
    Unigene Representative Sequence: NM_198686
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000267512(uc001xhz.2 uc021rur.1 uc021rus.1 uc021rut.1)
    ENST00000533601 ENST00000585059 ENST00000426039 ENST00000554593 ENST00000555256
    ENST00000436278

    miRNA
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    8/56 QIAGEN miScript miRNA Assays for microRNAs that regulate RAB15 (see all 56):
    hsa-miR-3164 hsa-let-7d hsa-miR-513a-5p hsa-miR-128 hsa-miR-29a hsa-miR-30d hsa-miR-766 hsa-miR-4267
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAB15
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAB15

    Additional cDNA sequence: 

    AB672631.2 AB672632.1 AB678452.1 AB678453.1 BC014511.1 BC040679.2 BX248046.1 BX640825.1 

    10 DOTS entries:

    DT.91655154  DT.100715880  DT.454380  DT.92426949  DT.100790904  DT.100714529  DT.97816418  DT.100715879 
    DT.95242640  DT.95257083 

    24/120 AceView cDNA sequences (see all 120):

    BG057625 CA424721 BM128186 CB044182 AW027845 BX248046 BX119534 CK300190 
    BX647017 BM975016 AI554311 BX397019 BM551913 CB158366 BX093757 BG766350 
    BQ188717 CA411919 BM049329 AW662473 BG676934 BX479105 BG760915 NM_198686 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for RAB15    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c
    SP1:                                      -     -                                       
    SP2:              -                       -     -                                       
    SP3:              -                             -                                       
    SP4:                                                                                    


    ECgene alternative splicing isoforms for RAB15

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RAB15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCTTGAGGCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    RAB15 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 4 LifeMap Cells 
    NameCategory
    PureStem™ progenitor E68 (Embryonic Progenitor Cell)
    PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)Intermediate Mesoderm, Kidney
    PureStem™ progenitor T42 (Embryonic Progenitor Cell)
    PureStem™ progenitor EN13 (Embryonic Progenitor Cell)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See RAB15 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RAB15

    SOURCE GeneReport for Unigene cluster: Hs.512492
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB15

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RAB15 gene from 3/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rab155 RAB15, member RAS oncogene family   --   12 (33.73 cM) 76797960 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    65(a)
    1 ↔ 1
    GL344688.1(1568-11726)
    honey bee
    (Apis mellifera)
    Insecta --
    --
    29(a)
    1 ↔ 1
    GroupUn.1604(3049-3357)


    ENSEMBL Gene Tree for RAB15 (if available)
    TreeFam Gene Tree for RAB15 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/416 NCBI SNPs in RAB15 are shown (see all 416    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1894968151,2
    --65412162(+) ACAAAC/TCTGAA 3 -- int10--------
    rs1920101991,2
    --65412187(+) CACCTC/TATGCC 3 -- int10--------
    rs1380184061,2
    --65412237(+) ACTCAC/TCTTGG 3 -- int10--------
    rs22775021,2
    C,F,H,--65412278(-) TTATCG/AAGAGG 3 -- int117Minor allele frequency- A:0.06EA NA MN NS 2682
    rs352636281,2
    C,F--65412377(+) GTAGAG/CAAGGG 3 -- int12Minor allele frequency- C:0.50NA 4
    rs1846139561,2
    --65412390(+) GACAAC/TGTTTG 3 -- int10--------
    rs22775011,2
    C,F,A,H,--65412441(-) GAAGCG/AGCTCC 3 -- int138Minor allele frequency- A:0.45EA NA NS WA CSA 5186
    rs1894833451,2
    --65412528(+) AGCCAC/TACCGG 3 -- int10--------
    rs1815322411,2
    --65412531(+) CACACC/TGGTGG 3 -- int1 spd10--------
    rs598654641,2
    --65412580(+) AATAGA/GTGAAC 3 -- ut31 int10--------

    HapMap Linkage Disequilibrium report for RAB15 (65412532 - 65439494 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for RAB15
         5 CNVs: 7038 76660 87249 76661 66653

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAB15
    DNA2.0 Custom Variant and Variant Library Synthesis for RAB15

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    RAB15 for disorders           About GeneDecksing

    3 diseases for RAB15:    About MalaCards
    differentiating neuroblastoma    pulmonary disease    neuroblastoma

    Human Genome Epidemiology (HuGE) Navigator: RAB15 (9 documents)

    Export disorders for RAB15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RAB15 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with RAB15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Rab15 effector protein: a novel protein for receptor recycling from the endocytic recycling compartment. (PubMed id 16195351)1, 2 Strick D.J. and Elferink L.A. (2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (2003)
    4. Evolution of the Rab family of small GTP-binding proteins. (PubMed id 11697911)1, 3 Pereira-Leal J.B. and Seabra M.C. (2001)
    5. Shotgun proteomics and network analysis of ubiquitin-r elated proteins from human breast carcinoma epithelial cells. (PubMed id 21853274)1 Zhou J....Liang S. (2012)
    6. Rab15 alternative splicing is altered in spheres of ne uroblastoma cells. (PubMed id 22427180)1 Pham T.V....Nishimura N. (2012)
    7. An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. (PubMed id 21319273)1 Neganova I....Lako M. (2011)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. Rab15 expression correlates with retinoic acid-induce d differentiation of neuroblastoma cells. (PubMed id 21491086)1 Nishimura N....Matsuo M. (2011)
    10. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1 Guey L.T....Malats N. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 376267 HGNC: 20150 AceView: RAB15 Ensembl:ENSG00000139998 euGenes: HUgn376267
    ECgene: RAB15 H-InvDB: RAB15

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RAB15 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RAB15 gene:
    Search GeneIP for patents involving RAB15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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