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Aliases for RAB15 Gene

Aliases for RAB15 Gene

  • RAB15, Member RAS Oncogene Family 2 3 5

External Ids for RAB15 Gene

Previous GeneCards Identifiers for RAB15 Gene

  • GC14M059207
  • GC14M063402
  • GC14M064482
  • GC14M065412
  • GC14M045582

Summaries for RAB15 Gene

GeneCards Summary for RAB15 Gene

RAB15 (RAB15, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB37.

UniProtKB/Swiss-Prot for RAB15 Gene

  • May act in concert with RAB3A in regulating aspects of synaptic vesicle membrane flow within the nerve terminal.

Gene Wiki entry for RAB15 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB15 Gene

Genomics for RAB15 Gene

Regulatory Elements for RAB15 Gene

Promoters for RAB15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RAB15 on UCSC Golden Path with GeneCards custom track

Genomic Location for RAB15 Gene

Chromosome:
14
Start:
64,945,814 bp from pter
End:
64,972,776 bp from pter
Size:
26,963 bases
Orientation:
Minus strand

Genomic View for RAB15 Gene

Genes around RAB15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB15 Gene

Proteins for RAB15 Gene

  • Protein details for RAB15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59190-RAB15_HUMAN
    Recommended name:
    Ras-related protein Rab-15
    Protein Accession:
    P59190
    Secondary Accessions:
    • G5EMR7
    • Q86TX7
    • Q8IW89

    Protein attributes for RAB15 Gene

    Size:
    212 amino acids
    Molecular mass:
    24391 Da
    Quaternary structure:
    • The GTP bound form of RAB15 interacts with REP15.

    Alternative splice isoforms for RAB15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAB15 Gene

Proteomics data for RAB15 Gene at MOPED

Post-translational modifications for RAB15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB15 Gene

No data available for DME Specific Peptides for RAB15 Gene

Domains & Families for RAB15 Gene

Gene Families for RAB15 Gene

Suggested Antigen Peptide Sequences for RAB15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P59190

UniProtKB/Swiss-Prot:

RAB15_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB15: view

Function for RAB15 Gene

Molecular function for RAB15 Gene

UniProtKB/Swiss-Prot Function:
May act in concert with RAB3A in regulating aspects of synaptic vesicle membrane flow within the nerve terminal.
genes like me logo Genes that share phenotypes with RAB15: view

Animal Model Products

miRNA for RAB15 Gene

miRTarBase miRNAs that target RAB15

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB15 Gene

Localization for RAB15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB15 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB15 Gene COMPARTMENTS Subcellular localization image for RAB15 gene
Compartment Confidence
endosome 5
extracellular 5
cytosol 4
plasma membrane 3
cytoskeleton 2
nucleus 2

Gene Ontology (GO) - Cellular Components for RAB15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048471 perinuclear region of cytoplasm IDA 16195351
genes like me logo Genes that share ontologies with RAB15: view

Pathways & Interactions for RAB15 Gene

genes like me logo Genes that share pathways with RAB15: view

Pathways by source for RAB15 Gene

1 Qiagen pathway for RAB15 Gene

Gene Ontology (GO) - Biological Process for RAB15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with RAB15: view

No data available for SIGNOR curated interactions for RAB15 Gene

Drugs & Compounds for RAB15 Gene

(1) Drugs for RAB15 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RAB15: view

Transcripts for RAB15 Gene

Unigene Clusters for RAB15 Gene

RAB15, member RAS oncogene family:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAB15 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - -
SP2: - - -
SP3: - -
SP4:

Relevant External Links for RAB15 Gene

GeneLoc Exon Structure for
RAB15
ECgene alternative splicing isoforms for
RAB15

Expression for RAB15 Gene

mRNA expression in normal human tissues for RAB15 Gene

mRNA differential expression in normal tissues according to GTEx for RAB15 Gene

This gene is overexpressed in Brain - Cerebellum (x5.2), Brain - Cerebellar Hemisphere (x5.0), and Brain - Cortex (x4.8).

Protein differential expression in normal tissues from HIPED for RAB15 Gene

This gene is overexpressed in Brain (34.4), Skin (19.4), and Pancreas (11.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB15 Gene



SOURCE GeneReport for Unigene cluster for RAB15 Gene Hs.512492

genes like me logo Genes that share expression patterns with RAB15: view

Protein tissue co-expression partners for RAB15 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for RAB15 Gene

Orthologs for RAB15 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for RAB15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB15 35
  • 99.37 (n)
  • 100 (a)
RAB15 36
  • 100 (a)
OneToOne
Species with no ortholog for RAB15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RAB15 Gene

ENSEMBL:
Gene Tree for RAB15 (if available)
TreeFam:
Gene Tree for RAB15 (if available)

Paralogs for RAB15 Gene

genes like me logo Genes that share paralogs with RAB15: view

Variants for RAB15 Gene

Structural Variations from Database of Genomic Variants (DGV) for RAB15 Gene

Variant ID Type Subtype PubMed ID
esv2748779 CNV Deletion 23290073
esv33119 CNV Gain 17666407
esv21993 CNV Gain 19812545

Variation tolerance for RAB15 Gene

Residual Variation Intolerance Score: 65.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.08; 1.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAB15 Gene

HapMap Linkage Disequilibrium report
RAB15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for RAB15 Gene

Disorders for RAB15 Gene

Relevant External Links for RAB15

Genetic Association Database (GAD)
RAB15
Human Genome Epidemiology (HuGE) Navigator
RAB15
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAB15

No disorders were found for RAB15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB15 Gene

Publications for RAB15 Gene

  1. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey L.T. … Malats N. (Eur. Urol. 2010) 3 48 67
  2. Evolution of the Rab family of small GTP-binding proteins. (PMID: 11697911) Pereira-Leal J.B. … Seabra M.C. (J. Mol. Biol. 2001) 2 3
  3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  4. Rab15 alternative splicing is altered in spheres of neuroblastoma cells. (PMID: 22427180) Pham T.V. … Nishimura N. (Oncol. Rep. 2012) 3
  5. A complete Rab screening reveals novel insights in Weibel-Palade body exocytosis. (PMID: 22899725) Zografou S. … Christoforidis S. (J. Cell. Sci. 2012) 3

Products for RAB15 Gene

Sources for RAB15 Gene

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