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Aliases for RAB15 Gene

Aliases for RAB15 Gene

  • RAB15, Member RAS Oncogene Family 2 3

External Ids for RAB15 Gene

Summaries for RAB15 Gene

GeneCards Summary for RAB15 Gene

RAB15 (RAB15, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB15 include lung cancer and neuroblastoma. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include GTP binding.

UniProtKB/Swiss-Prot for RAB15 Gene

  • May act in concert with RAB3A in regulating aspects of synaptic vesicle membrane flow within the nerve terminal.

Gene Wiki entry for RAB15 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB15 Gene

Genomics for RAB15 Gene

Genomic Location for RAB15 Gene

Start:
64,945,814 bp from pter
End:
64,972,776 bp from pter
Size:
26,963 bases
Orientation:
Minus strand

Genomic View for RAB15 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAB15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB15 Gene

Regulatory Elements for RAB15 Gene

Proteins for RAB15 Gene

  • Protein details for RAB15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59190-RAB15_HUMAN
    Recommended name:
    Ras-related protein Rab-15
    Protein Accession:
    P59190
    Secondary Accessions:
    • G5EMR7
    • Q86TX7
    • Q8IW89

    Protein attributes for RAB15 Gene

    Size:
    212 amino acids
    Molecular mass:
    24391 Da
    Quaternary structure:
    • The GTP bound form of RAB15 interacts with REP15.

    Alternative splice isoforms for RAB15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAB15 Gene

Proteomics data for RAB15 Gene at MOPED

Post-translational modifications for RAB15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB15 Gene

No data available for DME Specific Peptides for RAB15 Gene

Domains for RAB15 Gene

Gene Families for RAB15 Gene

HGNC:
  • RAB :RAB, member RAS oncogene

UniProtKB/Swiss-Prot:

RAB15_HUMAN
Family:
  • Belongs to the small GTPase superfamily. Rab family.:
    • P59190
genes like me logo Genes that share domains with RAB15: view

Function for RAB15 Gene

Molecular function for RAB15 Gene

UniProtKB/Swiss-Prot Function: May act in concert with RAB3A in regulating aspects of synaptic vesicle membrane flow within the nerve terminal.

Gene Ontology (GO) - Molecular Function for RAB15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IBA --
GO:0005515 protein binding IPI 16195351
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RAB15: view

Phenotypes for RAB15 Gene

GenomeRNAi human phenotypes for RAB15:
genes like me logo Genes that share phenotypes with RAB15: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RAB15 Gene

Localization for RAB15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB15 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB15 Gene COMPARTMENTS Subcellular localization image for RAB15 gene
Compartment Confidence
plasma membrane 5
cytosol 3
endosome 2
nucleus 2
cytoskeleton 1
extracellular 1

Gene Ontology (GO) - Cellular Components for RAB15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005737 cytoplasm IDA 16195351
GO:0005886 plasma membrane IEA --
GO:0010008 endosome membrane IDA 16195351
genes like me logo Genes that share ontologies with RAB15: view

Pathways for RAB15 Gene

genes like me logo Genes that share pathways with RAB15: view

Pathways by source for RAB15 Gene

1 Qiagen pathway for RAB15 Gene

Gene Ontology (GO) - Biological Process for RAB15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport IBA --
GO:0006904 vesicle docking involved in exocytosis IBA --
GO:0006913 nucleocytoplasmic transport --
GO:0007165 signal transduction --
genes like me logo Genes that share ontologies with RAB15: view

Compounds for RAB15 Gene

(1) HMDB Compounds for RAB15 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with RAB15: view

Transcripts for RAB15 Gene

Unigene Clusters for RAB15 Gene

RAB15, member RAS oncogene family:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAB15 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - -
SP2: - - -
SP3: - -
SP4:

Relevant External Links for RAB15 Gene

GeneLoc Exon Structure for
RAB15
ECgene alternative splicing isoforms for
RAB15

Expression for RAB15 Gene

mRNA expression in normal human tissues for RAB15 Gene

mRNA differential expression in normal tissues according to GTEx for RAB15 Gene

This gene is overexpressed in Brain - Cerebellum (5.2), Brain - Cerebellar Hemisphere (5.0), and Brain - Cortex (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB15 Gene

SOURCE GeneReport for Unigene cluster for RAB15 Gene Hs.512492

genes like me logo Genes that share expressions with RAB15: view

Orthologs for RAB15 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for RAB15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB15 36
  • 99.37 (n)
  • 100 (a)
RAB15 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rab15 16
Species with no ortholog for RAB15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RAB15 Gene

ENSEMBL:
Gene Tree for RAB15 (if available)
TreeFam:
Gene Tree for RAB15 (if available)

Paralogs for RAB15 Gene

genes like me logo Genes that share paralogs with RAB15: view

No data available for Paralogs for RAB15 Gene

Variants for RAB15 Gene

Structural Variations from Database of Genomic Variants (DGV) for RAB15 Gene

Variant ID Type Subtype PubMed ID
esv2748779 CNV Deletion 23290073
esv33119 CNV Gain 17666407
esv21993 CNV Gain 19812545

Relevant External Links for RAB15 Gene

HapMap Linkage Disequilibrium report
RAB15

No data available for Sequence variations from dbSNP and Humsavar for RAB15 Gene

Disorders for RAB15 Gene

(2) MalaCards Diseases for RAB15 Gene

Search for RAB15 Gene in MalaCards »

Relevant External Links for RAB15

Genetic Association Database (GAD)
RAB15
Human Genome Epidemiology (HuGE) Navigator
RAB15
genes like me logo Genes that share disorders with RAB15: view

No data available for UniProtKB/Swiss-Prot for RAB15 Gene

Publications for RAB15 Gene

  1. Evolution of the Rab family of small GTP-binding proteins. (PMID: 11697911) Pereira-Leal J.B. … Seabra M.C. (J. Mol. Biol. 2001) 2 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Rab15 effector protein: a novel protein for receptor recycling from the endocytic recycling compartment. (PMID: 16195351) Strick D.J. … Elferink L.A. (Mol. Biol. Cell 2005) 3 4
  4. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 3 4
  5. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PMID: 18676680) Hosgood H.D. … Lan Q. (Carcinogenesis 2008) 3 49

Products for RAB15 Gene

Sources for RAB15 Gene

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