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Aliases for RAB14 Gene

Aliases for RAB14 Gene

  • RAB14, Member RAS Oncogene Family 2 3 5
  • BA165P4.3 (Member RAS Oncogene Family) 2 3
  • Small GTP Binding Protein RAB14 2 3
  • F Protein-Binding Protein 1 2 3
  • RAB-14 3
  • FBP 3

External Ids for RAB14 Gene

Previous GeneCards Identifiers for RAB14 Gene

  • GC09M115045
  • GC09M115586
  • GC09M117394
  • GC09M119316
  • GC09M119299
  • GC09M121019
  • GC09M122980
  • GC09M123940
  • GC09M093558

Summaries for RAB14 Gene

Entrez Gene Summary for RAB14 Gene

  • RAB14 belongs to the large RAB family of low molecular mass GTPases that are involved in intracellular membrane trafficking. These proteins act as molecular switches that flip between an inactive GDP-bound state and an active GTP-bound state in which they recruit downstream effector proteins onto membranes (Junutula et al., 2004 [PubMed 15004230]).[supplied by OMIM, Mar 2009]

GeneCards Summary for RAB14 Gene

RAB14 (RAB14, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Translocation of GLUT4 to the plasma membrane and AMPK signaling pathway. GO annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB39A.

UniProtKB/Swiss-Prot for RAB14 Gene

  • Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion.

Gene Wiki entry for RAB14 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB14 Gene

Genomics for RAB14 Gene

Regulatory Elements for RAB14 Gene

Enhancers for RAB14 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RAB14 on UCSC Golden Path with GeneCards custom track

Genomic Location for RAB14 Gene

Chromosome:
9
Start:
121,178,137 bp from pter
End:
121,223,014 bp from pter
Size:
44,878 bases
Orientation:
Minus strand

Genomic View for RAB14 Gene

Genes around RAB14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB14 Gene

Proteins for RAB14 Gene

  • Protein details for RAB14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61106-RAB14_HUMAN
    Recommended name:
    Ras-related protein Rab-14
    Protein Accession:
    P61106
    Secondary Accessions:
    • B3KR31
    • P35287
    • Q5JVD4
    • Q6Q7K5
    • Q969L0
    • Q9UI11

    Protein attributes for RAB14 Gene

    Size:
    215 amino acids
    Molecular mass:
    23897 Da
    Quaternary structure:
    • Interacts with KIF16B (By similarity). Interacts with ZFYVE20.
    SequenceCaution:
    • Sequence=CAI12361.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RAB14 Gene

neXtProt entry for RAB14 Gene

Proteomics data for RAB14 Gene at MOPED

Post-translational modifications for RAB14 Gene

  • Ubiquitination at Lys 35 and Lys 171
  • Modification sites at PhosphoSitePlus

Other Protein References for RAB14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RAB14 Gene

Domains & Families for RAB14 Gene

Gene Families for RAB14 Gene

Suggested Antigen Peptide Sequences for RAB14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P61106

UniProtKB/Swiss-Prot:

RAB14_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB14: view

Function for RAB14 Gene

Molecular function for RAB14 Gene

UniProtKB/Swiss-Prot Function:
Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion.
genes like me logo Genes that share phenotypes with RAB14: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RAB14

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB14 Gene

Localization for RAB14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB14 Gene

Recycling endosome. Early endosome membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus, trans-Golgi network membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle, phagosome. Note=Recruited to recycling endosomes by DENND6A (PubMed:22595670). Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211). {ECO:0000269 PubMed:21255211, ECO:0000269 PubMed:22595670}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB14 Gene COMPARTMENTS Subcellular localization image for RAB14 gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5
endosome 5
extracellular 5
golgi apparatus 5
lysosome 5
plasma membrane 5
vacuole 5
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RAB14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005769 early endosome IEA,ISS --
GO:0005770 late endosome ISS --
GO:0005791 rough endoplasmic reticulum ISS --
GO:0005794 Golgi apparatus IBA --
genes like me logo Genes that share ontologies with RAB14: view

Pathways & Interactions for RAB14 Gene

genes like me logo Genes that share pathways with RAB14: view

Pathways by source for RAB14 Gene

1 Qiagen pathway for RAB14 Gene

Gene Ontology (GO) - Biological Process for RAB14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006895 Golgi to endosome transport IEA,TAS 15004230
GO:0006913 nucleocytoplasmic transport IEA --
GO:0007589 body fluid secretion IEA --
GO:0008543 fibroblast growth factor receptor signaling pathway IEA,ISS --
GO:0009790 embryo development IEA,ISS --
genes like me logo Genes that share ontologies with RAB14: view

No data available for SIGNOR curated interactions for RAB14 Gene

Drugs & Compounds for RAB14 Gene

No Compound Related Data Available

Transcripts for RAB14 Gene

mRNA/cDNA for RAB14 Gene

Unigene Clusters for RAB14 Gene

RAB14, member RAS oncogene family:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAB14 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7
SP1: -
SP2: - -
SP3:
SP4:
SP5: -
SP6: -

Relevant External Links for RAB14 Gene

GeneLoc Exon Structure for
RAB14
ECgene alternative splicing isoforms for
RAB14

Expression for RAB14 Gene

mRNA expression in normal human tissues for RAB14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RAB14 Gene

This gene is overexpressed in Nasal epithelium (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB14 Gene



SOURCE GeneReport for Unigene cluster for RAB14 Gene Hs.371563

genes like me logo Genes that share expression patterns with RAB14: view

Protein tissue co-expression partners for RAB14 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RAB14 Gene

Orthologs for RAB14 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAB14 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RAB14 35
  • 91.16 (n)
  • 100 (a)
RAB14 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAB14 35
  • 95.5 (n)
  • 100 (a)
RAB14 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rab14 35
  • 94.42 (n)
  • 100 (a)
Rab14 16
Rab14 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RAB14 35
  • 99.84 (n)
  • 100 (a)
RAB14 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rab14 35
  • 94.57 (n)
  • 99.53 (a)
oppossum
(Monodelphis domestica)
Mammalia RAB14 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAB14 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAB14 35
  • 89.46 (n)
  • 100 (a)
RAB14 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAB14 36
  • 100 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rab14 35
  • 81.55 (n)
  • 100 (a)
Str.5963 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.8480 35
zebrafish
(Danio rerio)
Actinopterygii Dr.7872 35
rab14l 35
  • 78.14 (n)
  • 98.6 (a)
rab14 36
  • 96 (a)
OneToMany
rab14 36
  • 96 (a)
OneToMany
rab14l 36
  • 99 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Rab14 37
  • 81 (a)
Rab14 36
  • 73 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F11A5.3 37
  • 51 (a)
F11A5.4 37
  • 55 (a)
rab-14 36
  • 85 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2213 35
bread mold
(Neurospora crassa)
Ascomycetes NCU01647 35
  • 53.2 (n)
  • 53.89 (a)
Species with no ortholog for RAB14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB14 Gene

ENSEMBL:
Gene Tree for RAB14 (if available)
TreeFam:
Gene Tree for RAB14 (if available)

Paralogs for RAB14 Gene

genes like me logo Genes that share paralogs with RAB14: view

Variants for RAB14 Gene

Sequence variations from dbSNP and Humsavar for RAB14 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
VAR_012986 -
rs942152 -- 121,189,407(+) TTCTG(C/T)GTAGG intron-variant
rs942153 -- 121,189,454(+) TGATC(A/G)TATCA intron-variant
rs1359085 -- 121,191,878(+) CCTGT(A/G)ACAGA intron-variant
rs7854324 -- 121,183,631(+) AAATA(C/G)TATAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB14 Gene

Variant ID Type Subtype PubMed ID
nsv820290 CNV Loss 19587683

Variation tolerance for RAB14 Gene

Residual Variation Intolerance Score: 52.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.02; 0.43% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RAB14 Gene

Disorders for RAB14 Gene

Relevant External Links for RAB14

Genetic Association Database (GAD)
RAB14
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAB14

No disorders were found for RAB14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB14 Gene

Publications for RAB14 Gene

  1. Rab14 and its exchange factor FAM116 link endocytic recycling and adherens junction stability in migrating cells. (PMID: 22595670) Linford A. … Barr F.A. (Dev. Cell 2012) 3 4 67
  2. Class I Rab11-family interacting proteins are binding targets for the Rab14 GTPase. (PMID: 19702578) Kelly E.E. … McCaffrey M.W. (Biol. Cell 2010) 3 23
  3. Rab14 is involved in membrane trafficking between the Golgi complex and endosomes. (PMID: 15004230) Junutula J.R. … Scheller R.H. (Mol. Biol. Cell 2004) 2 3
  4. Small GTP-binding proteins in human endothelial cells. (PMID: 9792283) de Leeuw H.P. … Voorberg J. (Br. J. Haematol. 1998) 2 3
  5. MIR144 and MIR451 regulate human erythropoiesis via RAB14. (PMID: 25312678) Kim M. … Civin C.I. (Br. J. Haematol. 2015) 3

Products for RAB14 Gene

Sources for RAB14 Gene

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