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Aliases for RAB14 Gene

Aliases for RAB14 Gene

  • RAB14, Member RAS Oncogene Family 2 3
  • BA165P4.3 (Member RAS Oncogene Family) 2 3
  • Small GTP Binding Protein RAB14 2 3
  • F Protein-Binding Protein 1 2 3
  • Ras-Related Protein Rab-14 3
  • RAB-14 3
  • FBP 3

External Ids for RAB14 Gene

Previous GeneCards Identifiers for RAB14 Gene

  • GC09M115045
  • GC09M115586
  • GC09M117394
  • GC09M119316
  • GC09M119299
  • GC09M121019
  • GC09M122980
  • GC09M123940
  • GC09M093558

Summaries for RAB14 Gene

Entrez Gene Summary for RAB14 Gene

  • RAB14 belongs to the large RAB family of low molecular mass GTPases that are involved in intracellular membrane trafficking. These proteins act as molecular switches that flip between an inactive GDP-bound state and an active GTP-bound state in which they recruit downstream effector proteins onto membranes (Junutula et al., 2004 [PubMed 15004230]).[supplied by OMIM, Mar 2009]

GeneCards Summary for RAB14 Gene

RAB14 (RAB14, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Clathrin derived vesicle budding and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB42.

UniProtKB/Swiss-Prot for RAB14 Gene

  • Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion.

Gene Wiki entry for RAB14 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB14 Gene

Genomics for RAB14 Gene

Regulatory Elements for RAB14 Gene

Genomic Location for RAB14 Gene

Start:
121,178,137 bp from pter
End:
121,223,014 bp from pter
Size:
44,878 bases
Orientation:
Minus strand

Genomic View for RAB14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAB14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB14 Gene

Proteins for RAB14 Gene

  • Protein details for RAB14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61106-RAB14_HUMAN
    Recommended name:
    Ras-related protein Rab-14
    Protein Accession:
    P61106
    Secondary Accessions:
    • B3KR31
    • P35287
    • Q5JVD4
    • Q6Q7K5
    • Q969L0
    • Q9UI11

    Protein attributes for RAB14 Gene

    Size:
    215 amino acids
    Molecular mass:
    23897 Da
    Quaternary structure:
    • Interacts with KIF16B (By similarity). Interacts with ZFYVE20.
    SequenceCaution:
    • Sequence=CAI12361.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RAB14 Gene

neXtProt entry for RAB14 Gene

Proteomics data for RAB14 Gene at MOPED

Post-translational modifications for RAB14 Gene

  • Ubiquitination at Lys35, Lys171, and Lys193
  • Modification sites at PhosphoSitePlus

Other Protein References for RAB14 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RAB14 Gene

Domains for RAB14 Gene

Gene Families for RAB14 Gene

HGNC:
  • RAB :RAB, member RAS oncogene

Suggested Antigen Peptide Sequences for RAB14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P61106

UniProtKB/Swiss-Prot:

RAB14_HUMAN :
  • P61106
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB14: view

Function for RAB14 Gene

Molecular function for RAB14 Gene

UniProtKB/Swiss-Prot Function: Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion.

Gene Ontology (GO) - Molecular Function for RAB14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity NAS 15004230
GO:0005515 protein binding IPI 16034420
GO:0005525 GTP binding IDA 16034420
GO:0019003 GDP binding IDA 16034420
GO:0031489 myosin V binding IPI 24006491
genes like me logo Genes that share ontologies with RAB14: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAB14

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RAB14 Gene

Localization for RAB14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB14 Gene

Recycling endosome. Early endosome membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus, trans-Golgi network membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Note=Recruited to recycling endosomes by DENND6A. Recruited to phagosomes containing S.aureus or M.tuberculosis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB14 Gene COMPARTMENTS Subcellular localization image for RAB14 gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5
endosome 5
golgi apparatus 5
lysosome 5
plasma membrane 5
vacuole 5
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RAB14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005622 intracellular IDA --
GO:0005634 nucleus --
GO:0005737 cytoplasm --
GO:0005764 lysosome ISS --
genes like me logo Genes that share ontologies with RAB14: view

Pathways for RAB14 Gene

genes like me logo Genes that share pathways with RAB14: view

Pathways by source for RAB14 Gene

1 Qiagen pathway for RAB14 Gene

Gene Ontology (GO) - Biological Process for RAB14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport IBA --
GO:0006895 Golgi to endosome transport TAS 15004230
GO:0006913 nucleocytoplasmic transport --
GO:0007165 signal transduction --
genes like me logo Genes that share ontologies with RAB14: view

Transcripts for RAB14 Gene

mRNA/cDNA for RAB14 Gene

(540) Selected AceView cDNA sequences:
(14) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RAB14 Gene

RAB14, member RAS oncogene family:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAB14

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB14 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7
SP1: -
SP2: - -
SP3:
SP4:
SP5: -
SP6: -

Relevant External Links for RAB14 Gene

GeneLoc Exon Structure for
RAB14
ECgene alternative splicing isoforms for
RAB14

Expression for RAB14 Gene

mRNA expression in normal human tissues for RAB14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB14 Gene

SOURCE GeneReport for Unigene cluster for RAB14 Gene Hs.371563

genes like me logo Genes that share expressions with RAB14: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RAB14 Gene

Orthologs for RAB14 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAB14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB14 35
  • 99.84 (n)
  • 100 (a)
RAB14 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RAB14 35
  • 91.16 (n)
  • 100 (a)
RAB14 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAB14 35
  • 95.5 (n)
  • 100 (a)
RAB14 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rab14 35
  • 94.42 (n)
  • 100 (a)
Rab14 16
Rab14 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAB14 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAB14 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rab14 35
  • 94.57 (n)
  • 99.53 (a)
chicken
(Gallus gallus)
Aves RAB14 35
  • 89.46 (n)
  • 100 (a)
RAB14 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAB14 36
  • 100 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8480 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rab14 35
  • 81.55 (n)
  • 100 (a)
Str.5963 35
zebrafish
(Danio rerio)
Actinopterygii Dr.7872 35
rab14 36
  • 96 (a)
OneToMany
rab14 36
  • 96 (a)
OneToMany
rab14l 35
  • 78.14 (n)
  • 98.6 (a)
rab14l 36
  • 99 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Rab14 36
  • 73 (a)
OneToOne
Rab14 37
  • 81 (a)
worm
(Caenorhabditis elegans)
Secernentea rab-14 36
  • 85 (a)
OneToOne
F11A5.4 37
  • 55 (a)
F11A5.3 37
  • 51 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01647 35
  • 53.2 (n)
  • 53.89 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2213 35
Species with no ortholog for RAB14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB14 Gene

ENSEMBL:
Gene Tree for RAB14 (if available)
TreeFam:
Gene Tree for RAB14 (if available)

Paralogs for RAB14 Gene

genes like me logo Genes that share paralogs with RAB14: view

Variants for RAB14 Gene

Sequence variations from dbSNP and Humsavar for RAB14 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs8619 -- 121,181,053(-) TCTCA(C/T)TGTAC utr-variant-3-prime
rs880612 -- 121,201,777(-) CTGCA(C/T)CTCTC utr-variant-5-prime
rs880613 -- 121,201,476(-) AGCGC(C/T)GCGGC intron-variant
rs942152 -- 121,189,407(+) TTCTG(C/T)GTAGG intron-variant
rs942153 -- 121,189,454(+) TGATC(A/G)TATCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB14 Gene

Variant ID Type Subtype PubMed ID
nsv820290 CNV Loss 19587683

Relevant External Links for RAB14 Gene

HapMap Linkage Disequilibrium report
RAB14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB14 Gene

Disorders for RAB14 Gene

Relevant External Links for RAB14

Genetic Association Database (GAD)
RAB14
genes like me logo Genes that share disorders with RAB14: view

No data available for UniProtKB/Swiss-Prot for RAB14 Gene

Publications for RAB14 Gene

  1. Small GTP-binding proteins in human endothelial cells. (PMID: 9792283) de Leeuw H.P. … Voorberg J. (Br. J. Haematol. 1998) 2 3
  2. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu R.-M. … Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4
  3. Structural basis of family-wide Rab GTPase recognition by rabenosyn- 5. (PMID: 16034420) Eathiraj S. … Lambright D.G. (Nature 2005) 3 4
  4. Rab14 and its exchange factor FAM116 link endocytic recycling and adherens junction stability in migrating cells. (PMID: 22595670) Linford A. … Barr F.A. (Dev. Cell 2012) 3 4
  5. Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes. (PMID: 21255211) Seto S. … Koide Y. (Traffic 2011) 3 4

Products for RAB14 Gene

Sources for RAB14 Gene

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