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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RAB14 Gene

protein-coding   GIFtS: 57
GCID: GC09M123940

RAB14, member RAS oncogene family
 Explore 1 disease affiliated with
RAB14 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RAB14    

Aliases
for RAB14 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
RAB14, Member RAS Oncogene Family1 2     F Protein-Binding Protein 12
FBP1 2     Ras-Related Protein Rab-142
RAB-141 2     Small GTP Binding Protein RAB142
BA165P4.3 (Member RAS Oncogene Family)2     

External Ids:    HGNC: 165241   Entrez Gene: 515522   Ensembl: ENSG000001193967   OMIM: 6126735   UniProtKB: P611063   

Export aliases for RAB14 gene to outside databases

Previous GC identifers: GC09M115045 GC09M115586 GC09M117394 GC09M119316 GC09M119299 GC09M121019 GC09M122980 GC09M093558


Summaries
for RAB14 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RAB14:
RAB14 belongs to the large RAB family of low molecular mass GTPases that are involved in intracellular membrane
trafficking. These proteins act as molecular switches that flip between an inactive GDP-bound state and an active
GTP-bound state in which they recruit downstream effector proteins onto membranes (Junutula et al., 2004 (PubMed
15004230)).(supplied by OMIM, Mar 2009)

UniProtKB/Swiss-Prot: RAB14_HUMAN, P61106
Function: Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development.
Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for
developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development.
May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Regulates, together with its
guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and
cell-cell adhesion

Gene Wiki entry for RAB14


Genomic Views
for RAB14 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RAB14 gene promoter:
         NF-AT2   AP-1   ATF-2   c-Jun   HNF-3beta   NF-AT1   NF-AT   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RAB14 promoter sequence
   Search SABiosciences Chromatin IP Primers for RAB14

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q32-q34.11   Ensembl cytogenetic band:  9q33.2   HGNC cytogenetic band: 9q32-q34.11

RAB14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAB14 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M123940:  view genomic region     (about GC identifiers)

Start:
 123,940,415 bp from pter      End:
 123,985,292 bp from pter
Size:
 44,878 bases      Orientation:
 minus strand

Proteins
for RAB14 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RAB14_HUMAN, P61106 (See protein sequence)
Recommended Name: Ras-related protein Rab-14  
Size: 215 amino acids; 23897 Da
Subunit: Interacts with KIF16B (By similarity). Interacts with ZFYVE20
Subcellular location: Recycling endosome. Early endosome membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus
membrane; Lipid-anchor; Cytoplasmic side (By similarity). Golgi apparatus, trans-Golgi network membrane; Lipid-anchor;
Cytoplasmic side. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic
side (By similarity). Note=Recruited to recycling endosomes by DENND6A. Recruited to phagosomes containing S.aureus or
M.tuberculosis
Sequence caution: Sequence=CAI12361.1; Type=Erroneous gene model prediction;
2 PDB 3D structures from and Proteopedia for RAB14:
1Z0F (3D)        4DRZ (3D)    
Secondary accessions: B3KR31 P35287 Q5JVD4 Q6Q7K5 Q969L0 Q9UI11

Explore the universe of human proteins at neXtProt for RAB14: NX_P61106

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P61106

    • RAB14 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_057406.2  
    ENSEMBL proteins: 
     ENSP00000362946   ENSP00000400107  
    Reactome Protein details: P61106
    Human Recombinant Protein Products: 
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    Novus Biologicals RAB14 Proteins
    Novus Biologicals RAB14 Lysate
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for RAB14
    Uscn Proteins for RAB14

    Gene Ontology (GO): 5/20 cellular component terms (GO ID links to tree view) (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005622intracellular IDA--
    GO:0005624membrane fraction ----
    GO:0005764lysosome ISS--
    GO:0005769early endosome ISS--


    RAB14 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for RAB14

    Protein Domains /
    Families
    for RAB14 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RAB14 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR003579 Small_GTPase_Rab_type

    Graphical View of Domain Structure for InterPro Entry P61106

    ProtoNet protein and cluster: P61106

    3 Blocks protein families:
    IPB002041 GTP-binding nuclear protein Ran
    IPB003577 Ras small GTPase
    IPB003578 Ras small GTPase


    UniProtKB/Swiss-Prot: RAB14_HUMAN, P61106
    Similarity: Belongs to the small GTPase superfamily. Rab family


    Function
    for RAB14 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RAB14_HUMAN, P61106
    Function: Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development.
    Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for
    developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development.
    May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Regulates, together with its
    guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and
    cell-cell adhesion

    miRNA
    Products:            		 OriGene 3'-UTR Clone: RAB14
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAB14
    8/142 QIAGEN miScript miRNA Assays for microRNAs that regulate RAB14 (see all 142):
    hsa-miR-605 hsa-miR-138-2* hsa-miR-376a* hsa-miR-508-5p hsa-miR-92b hsa-miR-761 hsa-miR-130b hsa-miR-509-3-5p
    SwitchGear 3'UTR luciferase reporter plasmid: RAB14 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAB14 (see all 7)
    OriGene shRNA RFP: RAB14
    OriGene siRNA: RAB14
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAB14

    Gene Editing
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    Clone
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    Search LifeMap BioReagents cell lines for RAB14

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001948glycoprotein binding ----
    GO:0003924GTPase activity NAS15004230
    GO:0005515protein binding IPI16034420
    GO:0005525GTP binding IDA16034420
    GO:0019003GDP binding IDA16034420


    RAB14 for ontologies           About GeneDecksing


    Animal Models:
         1 MGI phenotypic allele for Rab14 (no phenotypes)

    RAB14 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for RAB14 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Membrane Trafficking
    		Membrane Trafficking1.00
    		Translocation of GLUT4 to the Plasma Membrane0.32
    2Sertoli-Sertoli Cell Junction Dynamics
    		Epithelial Tight Junctions0.36

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RAB14
        Epithelial Tight Junctions

    2        Reactome Pathways for RAB14
        Membrane Trafficking
    Translocation of GLUT4 to the Plasma Membrane



    RAB14 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RAB14

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/41 Interacting proteins for RAB14 (P611062, 3 ENSP000003629464) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OCRLQ019682, 3, ENSP000003601544MINT-2882965 MINT-2882815 MINT-2883141 I2D: score=2 STRING: ENSP00000360154
    HGSO149642, 3, ENSP000003312014MINT-3369773 MINT-3369790 I2D: score=1 STRING: ENSP00000331201
    AP1G1O437472, 3, ENSP000003771484MINT-3369736 I2D: score=1 STRING: ENSP00000377148
    EEA1Q150752, 3, ENSP000003179554MINT-3369756 I2D: score=1 STRING: ENSP00000317955
    CHMP243863, ENSP000003503864I2D: score=1 STRING: ENSP00000350386
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process NAS15004230
    GO:0006895Golgi to endosome transport TAS15004230
    GO:0007264small GTPase mediated signal transduction NAS--
    GO:0007269neurotransmitter secretion NAS--
    GO:0007589body fluid secretion ----


    RAB14 for ontologies           About GeneDecksing



    Drugs & Compounds
    for RAB14 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RAB14
    Search CenterWatch for drugs/clinical trials and news about RAB14 

    Transcripts
    for RAB14 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RAB14 gene: 
    NM_016322.3  

    Unigene Cluster for RAB14:

    RAB14, member RAS oncogene family
    Hs.371563  [show with all ESTs]
    Unigene Representative Sequence: NM_016322
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373840(uc004blc.3) ENST00000451303

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAB14
    8/142 QIAGEN miScript miRNA Assays for microRNAs that regulate RAB14 (see all 142):
    hsa-miR-605 hsa-miR-138-2* hsa-miR-376a* hsa-miR-508-5p hsa-miR-92b hsa-miR-761 hsa-miR-130b hsa-miR-509-3-5p
    SwitchGear 3'UTR luciferase reporter plasmid: RAB14 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAB14 (see all 7)
    OriGene shRNA RFP: RAB14
    OriGene siRNA: RAB14
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAB14
    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB14 
    Primer
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RAB14
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAB14
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAB14

    Additional cDNA sequence: 

    AF052113.1 AF112206.1 AF152463.1 AF203689.1 AF498949.1 AK000447.1 AK023524.1 AK090889.1 
    AL110256.1 AL162081.1 AY553875.1 BC006081.1 BC013057.1 CR457394.1 

    24/25 DOTS entries (see all 25):

    DT.100879142  DT.100879132  DT.449003  DT.100879144  DT.100879133  DT.121211889  DT.100879143  DT.100879136 
    DT.100879141  DT.121211914  DT.100879135  DT.92460697  DT.95263523  DT.97797745  DT.100879140  DT.121211758 
    DT.121211837  DT.121211855  DT.121211931  DT.95362804  DT.100879146  DT.306590  DT.75191851  DT.99964048 

    24/540 AceView cDNA sequences (see all 540):

    R20783 AA946744 AA370732 BM676134 CB857921 CF272364 AA351479 AA011089 
    BU675906 BM874369 AA149794 AA055315 AA831237 F10946 BM905726 AA055314 
    AA594361 AK090889 AA830236 CA445069 AI929543 CB155283 BE222207 AI497730 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for RAB14 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7
    SP1:                                      -                                 
    SP2:                                      -     -                           
    SP3:                                                                        
    SP4:                                                                        
    SP5:                                      -                                 


    ECgene alternative splicing isoforms for RAB14

    Expression
    for RAB14 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RAB14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACCTGCTGGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    RAB14 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartEndocardiumEndocardial Tube CellsEndocardium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See RAB14 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RAB14

    SOURCE GeneReport for Unigene cluster: Hs.371563
        SABiosciences Custom PCR Arrays for RAB14
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAB14
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB14

    Orthologs
    for RAB14 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for RAB14 gene from 6/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves RAB141 RAB14, member RAS oncogene family 89.46(n)
    100(a)    		   417119  NM_001012796.1  NP_001012814.1 
    lizard
    (Anolis carolinensis)    		 Reptilia RAB146
    		 --
    		 100(a)
    		 1 ↔ 1
    		 AAWZ02036218(9955-18341)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.84802 Xenopus laevis transcribed sequence with strong similarity to protein pirT47160 (H.sapiens) T47160 hypothetical protein DKFZp762K0911.1 - human less 84.78(n)    CA971378.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.78722 Danio rerio mRNA similar to RAB14, member RAS oncogene family (cDNA clone MGC55532 IMAGE2642114), complete cds less 80.03(n)    BC045374.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Rab143 GTP binding 81(a)   35A4   --
    worm
    (Caenorhabditis elegans)    		 Secernentea F11A5.43 RAS related protein 55(a)
    (best of 2)    		   V(16198272-16198883)   --


    ENSEMBL Gene Tree for RAB14 (if available)
    TreeFam Gene Tree for RAB14 (if available) 

    Paralogs
    for RAB14 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RAB14 gene
    RAB39A2  RAB2A2  RAB252  RAB4B2  RAB39B2  RAB11B2  RAB422  RAB4A2  
    RAB11A2  RAB2B2  
    18/84 SIMAP similar genes for RAB14 using alignment to 1 protein entry:     RAB14_HUMAN(see all similar genes):
    DKFZp313C1541    RAB4B    RAB2A    RAB4A    RAB2B    RAB8B
    RAB26    RAB13    RAB17    RAB37    RAB30    RAB11A
    RAB10    RAB11B    RAB5C    RAB15    RAB8A    DKFZp686J07132

    RAB14 for paralogs           About GeneDecksing



    Genomic Variants
    for RAB14 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/404 NCBI SNPs in RAB14 are shown (see all 404)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 9 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1810695731,2
    		--123940464(+) TGAACC/TGTTAA 1 -- ut310--------
    rs791891751,2
    		C,--123940477(+) TACGGG/TATCAA 1 -- ut310--------
    rs1175047231,2
    		F,--123940491(+) AGTTAC/AAATAA 1 -- ut311Minor allele frequency- A:0.04EA 120
    rs1129975331,2
    		C,--123940528(+) TACACAGTA/-  
                AGTTC     		1 -- ut311Minor allele frequency- -:0.50CSA 2
    rs559054001,2
    		C,F,--123940584(+) TACATT/CTTTTG 1 -- ut311Minor allele frequency- C:0.07NA 120
    rs757760931,2
    		C,F,--123940593(+) TGTTTC/AAAGTC 1 -- ut311Minor allele frequency- A:0.04WA 118
    rs563356051,2
    		C,F,--123940652(+) TCTGGG/AACACA 1 -- ut313Minor allele frequency- A:0.12WA NA EA 358
    rs717182691,2
    		C,--123940764(+) TTTGG-/TCTTT 
                TCTTC     		1 -- ut310--------
    rs754371051,2
    		C,F,--123940778(+) CTGTTT/CAGGGG 1 -- ut311Minor allele frequency- C:0.04WA 118
    rs768769331,2
    		C,F,--123940796(+) TGAACC/GACTCA 1 -- ut317Minor allele frequency- G:0.49NA CSA WA EA 366

    HapMap Linkage Disequilibrium report for RAB14 (123940415 - 123985292 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for RAB14
         1 CNV: 59506

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    Disorders / Diseases
    for RAB14 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RAB14 for disorders           About GeneDecksing

    OMIM gene information: 612673    OMIM disorders: --

    1 disease for RAB14:    About MalaCards
    lung cancer


    Export disorders for RAB14 gene to outside databases

    Publications
    for RAB14 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RAB14 gene, integrated from 9 sources (see all 42):
    (articles sorted by number of sources associating them with RAB14)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Rab14 and its exchange factor FAM116 link endocytic re cycling and adherens junction stability in migrating cells. (PubMed id 22595670)1, 2 Linford A....Barr F.A. (2012)
    2. Structural basis of family-wide Rab GTPase recognition by rabenosyn- 5. (PubMed id 16034420)1, 2 Eathiraj S.... Lambright D.G. (2005)
    3. Rab14 is involved in membrane trafficking between the Golgi complex and endosomes. (PubMed id 15004230)1, 3 Junutula J.R....Scheller R.H. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (2000)
    8. Small GTP-binding proteins in human endothelial cells . (PubMed id 9792283)1, 3 de Leeuw H.P....Voorberg J. (1998)
    9. Class I Rab11-family interacting proteins are binding targets for the Rab14 GTPase. (PubMed id 19702578)1, 9 Kelly E.E....McCaffrey M.W. (2010)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    External Searches for RAB14 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    Genome Databases showing RAB14 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51552 HGNC: 16524 AceView: RAB14 Ensembl:ENSG00000119396 euGenes: HUgn51552
    ECgene: RAB14 H-InvDB: RAB14

    Other Databases showing RAB14 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RAB14 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RAB14 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAB14 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for RAB14 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RAB14 gene:
    Search GeneIP for patents involving RAB14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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