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RAB14 Gene

protein-coding   GIFtS: 61
GCID: GC09M123940

RAB14, Member RAS Oncogene Family

  Search for RAB14
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RAB14, Member RAS Oncogene Family1 2     FBP2
BA165P4.3 (Member RAS Oncogene Family)1 2     RAB-142
F Protein-Binding Protein 11 2     Ras-Related Protein Rab-142
Small GTP Binding Protein RAB141 2     

External Ids:    HGNC: 165241   Entrez Gene: 515522   Ensembl: ENSG000001193967   OMIM: 6126735   UniProtKB: P611063   

Export aliases for RAB14 gene to outside databases

Previous GC identifers: GC09M115045 GC09M115586 GC09M117394 GC09M119316 GC09M119299 GC09M121019 GC09M122980 GC09M093558


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RAB14 Gene:
RAB14 belongs to the large RAB family of low molecular mass GTPases that are involved in intracellular membrane
trafficking. These proteins act as molecular switches that flip between an inactive GDP-bound state and an active
GTP-bound state in which they recruit downstream effector proteins onto membranes (Junutula et al., 2004 (PubMed
15004230)).(supplied by OMIM, Mar 2009)

GeneCards Summary for RAB14 Gene:
RAB14 (RAB14, member RAS oncogene family) is a protein-coding gene. GO annotations related to this gene include GDP binding and GTP binding. An important paralog of this gene is RAB19.

UniProtKB/Swiss-Prot: RAB14_HUMAN, P61106
Function: Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic
development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a
key process for developing basement membrane and epiblast and primitive endoderm lineages during early
postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By
similarity). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic
transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion

Gene Wiki entry for RAB14 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NC_018920.2  NT_008470.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the RAB14 gene promoter:
         NF-AT2   AP-1   ATF-2   c-Jun   HNF-3beta   NF-AT1   NF-AT   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RAB14 promoter sequence
   Search Chromatin IP Primers for RAB14

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RAB14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q32-q34.11   Ensembl cytogenetic band:  9q33.2   HGNC cytogenetic band: 9q32-q34.11

RAB14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAB14 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M123940:  view genomic region     (about GC identifiers)

Start:
123,940,415 bp from pter      End:
123,985,292 bp from pter
Size:
44,878 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RAB14_HUMAN, P61106 (See protein sequence)
Recommended Name: Ras-related protein Rab-14  
Size: 215 amino acids; 23897 Da
Subunit: Interacts with KIF16B (By similarity). Interacts with ZFYVE20
Sequence caution: Sequence=CAI12361.1; Type=Erroneous gene model prediction;
2 PDB 3D structures from and Proteopedia for RAB14:
1Z0F (3D)        4DRZ (3D)    
Secondary accessions: B3KR31 P35287 Q5JVD4 Q6Q7K5 Q969L0 Q9UI11

Explore the universe of human proteins at neXtProt for RAB14: NX_P61106

Explore proteomics data for RAB14 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys35, Lys171, Lys193
  • Modification sites at PhosphoSitePlus

  • See RAB14 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057406.2  
    ENSEMBL proteins: 
     ENSP00000362946   ENSP00000400107  
    Reactome Protein details: P61106

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RAB: RAB, member RAS oncogene

    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR003579 Small_GTPase_Rab_type
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry P61106

    ProtoNet protein and cluster: P61106

    3 Blocks protein domains:
    IPB002041 GTP-binding nuclear protein Ran
    IPB003577 Ras small GTPase
    IPB003578 Ras small GTPase


    UniProtKB/Swiss-Prot: RAB14_HUMAN, P61106
    Similarity: Belongs to the small GTPase superfamily. Rab family


    Find genes that share domains with RAB14           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RAB14_HUMAN, P61106
    Function: Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic
    development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a
    key process for developing basement membrane and epiblast and primitive endoderm lineages during early
    postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By
    similarity). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic
    transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity NAS15004230
    GO:0005515protein binding IPI16034420
    GO:0005525GTP binding IDA16034420
    GO:0019003GDP binding IDA16034420
         
    Find genes that share ontologies with RAB14           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Rab14 (no phenotypes)

    Find genes that share phenotypes with RAB14           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RAB14
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    miRNA
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    hsa-mir-155-5p (MIRT020520), hsa-mir-151a-5p (MIRT019523), hsa-mir-30a-5p (MIRT028469), hsa-mir-19a-3p (MIRT031309), hsa-mir-451a (MIRT006533)

    Block miRNA regulation of human, mouse, rat RAB14 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RAB14 (see all 142):
    hsa-miR-605 hsa-miR-138-2* hsa-miR-376a* hsa-miR-508-5p hsa-miR-92b hsa-miR-761 hsa-miR-130b hsa-miR-509-3-5p
    SwitchGear 3'UTR luciferase reporter plasmidRAB14 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB14
    Addgene plasmids for RAB14 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RAB14_HUMAN, P61106: Recycling endosome. Early endosome membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus
    membrane; Lipid-anchor; Cytoplasmic side (By similarity). Golgi apparatus, trans-Golgi network membrane;
    Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane;
    Lipid-anchor; Cytoplasmic side (By similarity). Note=Recruited to recycling endosomes by DENND6A. Recruited to
    phagosomes containing S.aureus or M.tuberculosis
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    endoplasmic reticulum5
    endosome5
    golgi apparatus5
    lysosome5
    plasma membrane5
    vacuole5
    nucleus2
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005622intracellular IDA--
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0005764lysosome ISS--

    Find genes that share ontologies with RAB14           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RAB14 About    
    See pathways by source

    SuperPathContained pathways About
    1Clathrin derived vesicle budding
    Membrane Trafficking0.32
    Translocation of GLUT4 to the Plasma Membrane0.32
    2Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions0.36


    Find genes that share SuperPaths with RAB14           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for RAB14
        Epithelial Tight Junctions


    1 Reactome Pathway for RAB14
        Translocation of GLUT4 to the plasma membrane


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RAB14
    Interactions:

        Search GeneGlobe Interaction Network for RAB14

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RAB14 (P611061, 2, 3 ENSP000003629464) via UniProtKB, MINT, STRING, and/or I2D (see all 68)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OCRLQ019681, 2, 3, ENSP000003601544EBI-1056404,EBI-6148898 MINT-2882965 MINT-2882815 MINT-2883141 I2D: score=2 STRING: ENSP00000360154
    HGSO149642, 3, ENSP000003312014MINT-3369773 MINT-3369790 I2D: score=1 STRING: ENSP00000331201
    AP1G1O437472, 3, ENSP000003771484MINT-3369736 I2D: score=1 STRING: ENSP00000377148
    EEA1Q150752, 3, ENSP000003179554MINT-3369756 I2D: score=1 STRING: ENSP00000317955
    CHMP243863, ENSP000003503864I2D: score=1 STRING: ENSP00000350386
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process NAS15004230
    GO:0006886intracellular protein transport ----
    GO:0006895Golgi to endosome transport TAS15004230
    GO:0006913nucleocytoplasmic transport ----
    GO:0007165signal transduction ----

    Find genes that share ontologies with RAB14           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RAB14



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RAB14 gene: 
    NM_016322.3  

    Unigene Cluster for RAB14:

    RAB14, member RAS oncogene family
    Hs.371563  [show with all ESTs]
    Unigene Representative Sequence: NM_016322
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373840(uc004blc.3) ENST00000451303
    miRNA
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    hsa-miR-605 hsa-miR-138-2* hsa-miR-376a* hsa-miR-508-5p hsa-miR-92b hsa-miR-761 hsa-miR-130b hsa-miR-509-3-5p
    SwitchGear 3'UTR luciferase reporter plasmidRAB14 3' UTR sequence
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    Additional mRNA sequence: 

    AF052113.1 AF112206.1 AF152463.1 AF203689.1 AF498949.1 AK000447.1 AK023524.1 AK090889.1 
    AL110256.1 AL162081.1 AY553875.1 BC006081.1 BC013057.1 CR457394.1 

    Selected DOTS entries (see all 26):

    DT.100879142  DT.449003  DT.100879132  DT.100879144  DT.100879133  DT.121211889  DT.100879143  DT.100879136 
    DT.100879135  DT.100879141  DT.121211914  DT.92460697  DT.95263523  DT.97797745  DT.100879140  DT.121211758 
    DT.121211765  DT.121211837  DT.121211855  DT.121211931  DT.75191851  DT.95362804  DT.99984039  DT.100879146 

    Selected AceView cDNA sequences (see all 540):

    AV710757 AF052113 AA812186 AI311469 AA781965 CB155283 BQ896715 BM905726 
    AA127099 AI247726 BU838452 CK821974 F10946 CF552024 CR615575 AI373514 
    T32848 AA630707 AI142546 BQ286087 BQ184427 BG675892 AL697845 CA432979 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RAB14 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7
    SP1:                                      -                                 
    SP2:                                      -     -                           
    SP3:                                                                        
    SP4:                                                                        
    SP5:                                      -                                 


    ECgene alternative splicing isoforms for RAB14

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RAB14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCTGCTGGT
    RAB14 Expression
    About this image


    RAB14 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Adult Dopaminergic Neurons Substantia Nigra pars Compacta
             posterior singulate   
     
     Neurons
             Adult Dopaminergic Neurons Substantia Nigra pars Compacta
     
     Esophagus (Gastrointestinal Tract)
    RAB14 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RAB14 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.371563
        Custom PCR Arrays for RAB14
    Primer
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB14

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RAB14 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rab141 , 5 RAB14, member RAS oncogene family1, 5 94.42(n)1
    100(a)1
      2 (23.42 cM)5
    683651  NM_026697.31  NP_080973.11 
     351802055 
    chicken
    (Gallus gallus)
    Aves RAB141 RAB14, member RAS oncogene family 89.46(n)
    100(a)
      417119  NM_001012796.1  NP_001012814.1 
    lizard
    (Anolis carolinensis)
    Reptilia RAB146
    RAB14, member RAS oncogene family
    100(a)
    1 ↔ 1
    AAWZ02036218(9955-18348)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.84802 Xenopus laevis transcribed sequence with strong similarity to protein pirT47160 (H.sapiens) T47160 hypothetical protein DKFZp762K0911.1 - human less 84.78(n)    CA971378.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.78722 Danio rerio mRNA similar to RAB14, member RAS oncogene family (cDNA clone MGC55532 IMAGE2642114), complete cds less 80.03(n)    BC045374.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rab143 GTP binding 81(a)   35A4   --
    worm
    (Caenorhabditis elegans)
    Secernentea F11A5.43 RAS related protein 55(a)
    (best of 2)
      V(16198272-16198883)   --


    ENSEMBL Gene Tree for RAB14 (if available)
    TreeFam Gene Tree for RAB14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RAB14 gene
    RAB192  RAB39A2  RAB2A2  RAB252  RAB432  RAB4B2  RAB39B2  RAB11B2  
    RAB11A2  RAB422  RAB4A2  RAB302  RAB4B-EGLN22  RAB2B2  
    Selected SIMAP similar genes for RAB14 using alignment to 1 protein entry:     RAB14_HUMAN(see all similar genes):
    DKFZp313C1541    RAB2A    RAB4A    RAB4B    RAB2B    RAB8B
    RAB26    RAB13    RAB17    RAB37    RAB11B    RAB30
    RAB10    RAB11A    RAB5C    RAB15    RAB8A    DKFZp686J07132

    Find genes that share paralogs with RAB14           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RAB14 (see all 478)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1810695731,2
    --123940464(+) TGAACC/TGTTAA 1 -- ut310--------
    rs791891751,2
    C--123940477(+) TACGGG/TATCAA 1 -- ut310--------
    rs1175047231,2
    C,F--123940491(+) AGTTAC/AAATAA 1 -- ut311Minor allele frequency- A:0.04EA 120
    rs1129975331,2
    C--123940528(+) TACACAGTA/-  
            
    AGTTC
    1 -- ut311Minor allele frequency- -:0.50CSA 2
    rs559054001,2
    C,F--123940584(+) TACATT/CTTTTG 1 -- ut311Minor allele frequency- C:0.07NA 120
    rs757760931,2
    C,F--123940593(+) TGTTTC/AAAGTC 1 -- ut311Minor allele frequency- A:0.04WA 118
    rs563356051,2
    C,F--123940652(+) TCTGGG/AACACA 1 -- ut313Minor allele frequency- A:0.12WA NA EA 358
    rs1113844821,2
    C--123940693(+) ATTATG/CTTTTC 1 -- ut311Minor allele frequency- C:0.50CSA 2
    rs717182691,2
    C--123940764(+) TTTGG-/TCTTT 
            
    TCTTC
    1 -- ut310--------
    rs754371051,2
    C,F--123940778(+) CTGTTT/CAGGGG 1 -- ut311Minor allele frequency- C:0.04WA 118

    HapMap Linkage Disequilibrium report for RAB14 (123940415 - 123985292 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RAB14:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv820290CNV Loss19587683

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RAB14
    DNA2.0 Custom Variant and Variant Library Synthesis for RAB14

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612673    OMIM disorders: --


    Find genes that share disorders with RAB14           About GenesLikeMe

    Genetic Association Database (GAD): RAB14

    Export disorders for RAB14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RAB14 gene, integrated from 10 sources (see all 58):
    (articles sorted by number of sources associating them with RAB14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Rab14 and its exchange factor FAM116 link endocytic recycling and adherens junction stability in migrating cells. (PubMed id 22595670)1, 2 Linford A.... Barr F.A. (Dev. Cell 2012)
    2. Structural basis of family-wide Rab GTPase recognition by rabenosyn- 5. (PubMed id 16034420)1, 2 Eathiraj S.... Lambright D.G. (Nature 2005)
    3. Rab14 is involved in membrane trafficking between the Golgi complex and endosomes. (PubMed id 15004230)1, 3 Junutula J.R....Scheller R.H. (Mol. Biol. Cell 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    8. Small GTP-binding proteins in human endothelial cells. (PubMed id 9792283)1, 3 de Leeuw H.P....Voorberg J. (Br. J. Haematol. 1998)
    9. Class I Rab11-family interacting proteins are binding targets for the Rab14 GTPase. (PubMed id 19702578)1, 9 Kelly E.E....McCaffrey M.W. (Biol. Cell 2010)
    10. VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (PLoS ONE 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51552 HGNC: 16524 AceView: RAB14 Ensembl:ENSG00000119396 euGenes: HUgn51552
    ECgene: RAB14 H-InvDB: RAB14

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RAB14 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAB14 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RAB14 gene:
    Search GeneIP for patents involving RAB14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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