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Aliases & Descriptions for RAB14
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| FBP 1, 2 | | OTTHUMP00000022008 2 | | RAB-14 1, 2 |
| | | Descriptions |
|---|
| F protein-binding protein 1 2 | | GTPase Rab14 2 | | RAB14, member RAS oncogene family 2 | | bA165P4.3 (member RAS oncogene family) 2 | | small GTP binding protein RAB14 2 |
|
| | Search outside databases for aliases for RAB14 genePrevious GC identifers: GC09M115045 GC09M115586 GC09M117394 GC09M119316 GC09M119299 GC09M121019 |
Summaries for RAB14(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for RAB14: RAB14 belongs to the large RAB family of low molecular mass GTPases that are involved in intracellular membrane trafficking. These proteins act as molecular switches that flip between an inactive GDP-bound state and an active GTP-bound state in which they recruit downstream effector proteins onto membranes (Junutula et al., 2004 [PubMed 15004230]).[supplied by OMIM] UniProtKB/Swiss-Prot: RAB14_HUMAN, P61106Function: May be involved in vesicular trafficking and neurotransmitter releaseGene Wiki entry for RAB14 |
Genomic Location for RAB14
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the RAB14 gene 
Entrez Gene cytogenetic band: 9q32-q34.11 Ensembl cytogenetic band: 9q33.2 HGNC cytogenetic band: 9q32-q34.11RAB14 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M122980:
(about GC identifiers)
Start:
|
122,980,237 bp from pter |
End:
|
123,003,913 bp from pter |
Size:
|
23,677 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000009.10 NT_008470.18
| Proteins for RAB14
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: RAB14_HUMAN, P61106 (See
protein sequence)Recommended Name: Ras-related protein Rab-14 Size: 215 amino acids; 23897 Da
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
Sequence caution: Sequence=CAI12361.1; Type=Erroneous gene model prediction;
PDB structure from and Proteopedia :1Z0F (3D)
 2AED (3D)
 
Secondary accessions: P35287 Q5JVD4 Q6Q7K5 Q969L0 Q9UI11Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_057406.2
ENSEMBL proteins: ENSP00000362946
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: RAB14 
5/12 Gene Ontology (GO) cellular component terms (links to tree view) (see all 12
): About this table
Antibodies for RAB14: Assays for RAB14: | Protein
Domains/ Families for RAB14(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P61106
ProtoNet protein and cluster: P61106 3 Blocks protein families: IPB002041 GTP-binding nuclear protein Ran IPB003577 Ras small GTPase IPB003578 Ras small GTPase
UniProtKB/Swiss-Prot: RAB14_HUMAN, P61106Similarity: Belongs to the small GTPase superfamily. Rab family | Gene Function for RAB14
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_016322
Applied Biosystems Silencer® siRNAs for RAB14
Sigma-Aldrich siRNA for RAB14  Sigma-Aldrich shRNA for RAB14  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_016322                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_016322                                  untagged cDNA clone in CMV expression vector: NM_016322 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_016322
UniProtKB/Swiss-Prot: RAB14_HUMAN, P61106Function: May be involved in vesicular trafficking and neurotransmitter release1 MGI phenotypic allele for Rab14 (no phenotypes)
4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for RAB14
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/10 Interacting proteins for RAB14 (ENSP000003629463 P611061, 2) via UniProtKB, MINT, and/or STRING (see all 10
)About this table
5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6
): About this table
|
Drugs & Compounds for RAB14(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|  |
Enzo Life Sciences drugs & compounds for RAB14 |
Browse Tocris compounds for RAB14
|
Transcripts for RAB14(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_016322
Sigma-Aldrich siRNA for RAB14  Sigma-Aldrich shRNA for RAB14  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_016322 REFSEQ mRNAs for RAB14 gene: NM_016322.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_016322               OriGene GFP tagged cDNA clone in CMV expression vector: NM_016322                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_016322                                  untagged cDNA clone in CMV expression vector: NM_016322  Additional cDNA sequence: AF052113.1 AF112206.1 AF152463.1 AF203689.1 AF498949.1 AK000447.1 AK023524.1 AK090889.1 AL110256.1 AL162081.1 AY553875.1 BC006081.1 BC013057.1 CR457394.1 CR606162.1 24 DOTS entries: DT.100879142 DT.449003 DT.100879132 DT.100879144 DT.100879133 DT.121211889 DT.100879143 DT.99964048 DT.100879136 DT.100879141 DT.121211914 DT.100879135 DT.92460697 DT.95263523 DT.100879140 DT.100879146 DT.121211758 DT.121211837 DT.121211855 DT.121211931 DT.306590 DT.75191851 DT.95362804 DT.99984039 24/540 AceView cDNA sequences (see all 540
):AK090889 AA831237 BU607732 R20783 AL697845 AA127099 AI368730 BP342289 AA599592 AL558818 AI369963 AI373514 AA343917 BU675906 AA779754 BM982522 BQ006202 CB305747 W73964 AA088698 CA413010 AI690999 AI311469 AI142546
highest scoring ESTs for RAB14:AA088835 AA221003 AA310214 AF052113 AI879125 AI929622 AK023524 AK090889 AL045542 AL162081 Unigene Cluster for RAB14: RAB14, member RAS oncogene family Hs.371563 [show with all ESTs]Unigene Representative Sequence: NM_016322
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for RAB14 (see all 6
)
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | |
| SP1: | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for RAB14
1 Ensembl transcript including schematic representation: ENST00000373840
|
Expression for RAB14
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| RAB14 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for RAB14
1 / 2 / 3 8 probe-sets matching RAB14 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.371563
Expression variation in blood from EXPOLDB for RAB14 |
Orthologs for RAB14
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for RAB14 gene from 5/15 species (see all 15
)
About this table Species with no ortholog for RAB14
ENSEMBL Gene Tree for RAB14 | Paralogs for RAB14(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for RAB14 gene
- RAB2A2 RAB4A2 RAB4B2 RAB2B2
|
SNPs/Variants for RAB14(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for RAB14 (up to first 250kb)
|
Disorders & Mutations for RAB14
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 612673
|
Medical News for RAB14(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for RAB14 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/21 PubMed articles for RAB14 gene (see all 21
): |
Search for RAB14
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing RAB14
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing RAB14
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RAB14(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for RAB14(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for RAB14:

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Incremental update: 13 Oct 2009
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