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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RAB14 Gene

protein-coding GIFtS: 57
GCID: GC09M123940

RAB14, member RAS oncogene family

Explore 1 disease affiliated with
RAB14 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
RAB14, Member RAS Oncogene Family¹ ²		F Protein-Binding Protein 1²
FBP¹ ²		Ras-Related Protein Rab-14²
RAB-14¹ ²		Small GTP Binding Protein RAB14²
BA165P4.3 (Member RAS Oncogene Family)²

External Ids:	HGNC: 16524¹	Entrez Gene: 51552²	Ensembl: ENSG00000119396⁷	OMIM: 612673⁵	UniProtKB: P61106³

Export aliases for RAB14 gene to outside databases

Previous GC identifers: GC09M115045 GC09M115586 GC09M117394 GC09M119316 GC09M119299 GC09M121019 GC09M122980 GC09M093558

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RAB14:

RAB14 belongs to the large RAB family of low molecular mass GTPases that are involved in intracellular membrane

trafficking. These proteins act as molecular switches that flip between an inactive GDP-bound state and an active

GTP-bound state in which they recruit downstream effector proteins onto membranes (Junutula et al., 2004 (PubMed

15004230)).(supplied by OMIM, Mar 2009)

UniProtKB/Swiss-Prot: RAB14_HUMAN, P61106

Function: Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development.

Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for

developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development.

May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Regulates, together with its

guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and

cell-cell adhesion

Gene Wiki entry for RAB14

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_008470.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RAB14 gene promoter:
NF-AT2 AP-1 ATF-2 c-Jun HNF-3beta NF-AT1 NF-AT
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RAB14 promoter sequence

Search SABiosciences Chromatin IP Primers for RAB14

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB14

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q32-q34.11 Ensembl cytogenetic band: 9q33.2 HGNC cytogenetic band: 9q32-q34.11

RAB14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAB14 gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M123940: view genomic region (about GC identifiers)

Start:	123,940,415 bp from pter	End:	123,985,292 bp from pter
Size:	44,878 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RAB14_HUMAN, P61106 (See protein sequence)

Recommended Name: Ras-related protein Rab-14

Size: 215 amino acids; 23897 Da

Subunit: Interacts with KIF16B (By similarity). Interacts with ZFYVE20

Subcellular location: Recycling endosome. Early endosome membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus

membrane; Lipid-anchor; Cytoplasmic side (By similarity). Golgi apparatus, trans-Golgi network membrane; Lipid-anchor;

Cytoplasmic side. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic

side (By similarity). Note=Recruited to recycling endosomes by DENND6A. Recruited to phagosomes containing S.aureus or

M.tuberculosis

Sequence caution: Sequence=CAI12361.1; Type=Erroneous gene model prediction;

2 PDB 3D structures from and Proteopedia for RAB14:

1Z0F (3D)

4DRZ (3D)

Secondary accessions: B3KR31 P35287 Q5JVD4 Q6Q7K5 Q969L0 Q9UI11

Explore the universe of human proteins at neXtProt for RAB14: NX_P61106

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P61106

RAB14 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_057406.2

ENSEMBL proteins:

ENSP00000362946 ENSP00000400107

Reactome Protein details: P61106
Human Recombinant Protein Products:

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	ProSpec Recombinant Protein for RAB14
	Uscn Proteins for RAB14

Gene Ontology (GO): 5/20 cellular component terms (GO ID links to tree view) (see all 20): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	IEA	--
GO:0005622	intracellular	IDA	--
GO:0005624	membrane fraction	--	--
GO:0005764	lysosome	ISS	--
GO:0005769	early endosome	ISS	--

RAB14 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RAB14 for domains About GeneDecksing

3 InterPro domains/families:

IPR005225 Small_GTP-bd_dom

IPR001806 Small_GTPase

IPR003579 Small_GTPase_Rab_type

Graphical View of Domain Structure for InterPro Entry P61106

ProtoNet protein and cluster: P61106

3 Blocks protein families:

IPB002041 GTP-binding nuclear protein Ran

IPB003577 Ras small GTPase

IPB003578 Ras small GTPase

UniProtKB/Swiss-Prot: RAB14_HUMAN, P61106

Similarity: Belongs to the small GTPase superfamily. Rab family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: RAB14_HUMAN, P61106

Function: Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development.

Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for

developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development.

May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Regulates, together with its

guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and

cell-cell adhesion

miRNA Products:		OriGene 3'-UTR Clone: RAB14 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAB14
		8/142 QIAGEN miScript miRNA Assays for microRNAs that regulate RAB14 (see all 142):
		hsa-miR-605 hsa-miR-138-2* hsa-miR-376a* hsa-miR-508-5p hsa-miR-92b hsa-miR-761 hsa-miR-130b hsa-miR-509-3-5p

		SwitchGear 3'UTR luciferase reporter plasmid: RAB14 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
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		Search LifeMap BioReagents cell lines for RAB14

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB14

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001948	glycoprotein binding	--	--
GO:0003924	GTPase activity	NAS	15004230
GO:0005515	protein binding	IPI	16034420
GO:0005525	GTP binding	IDA	16034420
GO:0019003	GDP binding	IDA	16034420

RAB14 for ontologies About GeneDecksing

Animal Models:
1 MGI phenotypic allele

for Rab14 (no phenotypes)

RAB14 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Membrane Trafficking

Membrane Trafficking

1.00

Translocation of GLUT4 to the Plasma Membrane

0.32

Sertoli-Sertoli Cell Junction Dynamics

Epithelial Tight Junctions

0.36

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RAB14

Epithelial Tight Junctions

2 Reactome Pathways for RAB14

	Membrane Trafficking
	Translocation of GLUT4 to the Plasma Membrane

RAB14 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for RAB14

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/41 Interacting proteins for RAB14 (P61106^{2, 3} ENSP00000362946⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 41)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
OCRL	Q01968²^,³, ENSP00000360154⁴	MINT-2882965 MINT-2882815 MINT-2883141 I2D: score=2 STRING: ENSP00000360154
HGS	O14964²^,³, ENSP00000331201⁴	MINT-3369773 MINT-3369790 I2D: score=1 STRING: ENSP00000331201
AP1G1	O43747²^,³, ENSP00000377148⁴	MINT-3369736 I2D: score=1 STRING: ENSP00000377148
EEA1	Q15075²^,³, ENSP00000317955⁴	MINT-3369756 I2D: score=1 STRING: ENSP00000317955
CHM	P24386³, ENSP00000350386⁴	I2D: score=1 STRING: ENSP00000350386

About this table

Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006184	GTP catabolic process	NAS	15004230
GO:0006895	Golgi to endosome transport	TAS	15004230
GO:0007264	small GTPase mediated signal transduction	NAS	--
GO:0007269	neurotransmitter secretion	NAS	--
GO:0007589	body fluid secretion	--	--

RAB14 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RAB14
Search CenterWatch for drugs/clinical trials and news about RAB14

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RAB14 gene:

NM_016322.3

Unigene Cluster for RAB14:

RAB14, member RAS oncogene family

Hs.371563 [show with all ESTs]

Unigene Representative Sequence: NM_016322

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000373840(uc004blc.3) ENST00000451303

miRNA Products:		OriGene 3'-UTR Clone: RAB14 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAB14
		8/142 QIAGEN miScript miRNA Assays for microRNAs that regulate RAB14 (see all 142):
		hsa-miR-605 hsa-miR-138-2* hsa-miR-376a* hsa-miR-508-5p hsa-miR-92b hsa-miR-761 hsa-miR-130b hsa-miR-509-3-5p

		SwitchGear 3'UTR luciferase reporter plasmid: RAB14 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAB14 (see all 7) OriGene shRNA RFP: RAB14 OriGene siRNA: RAB14
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Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAB14 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAB14 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: RAB14 (NM_016322)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAB14
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB14

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAB14 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat RAB14
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAB14
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAB14

Additional cDNA sequence:

AF052113.1 AF112206.1 AF152463.1 AF203689.1 AF498949.1 AK000447.1 AK023524.1 AK090889.1

AL110256.1 AL162081.1 AY553875.1 BC006081.1 BC013057.1 CR457394.1

24/25 DOTS entries (see all 25):

DT.100879142 DT.100879132 DT.449003 DT.100879144 DT.100879133 DT.121211889 DT.100879143 DT.100879136

DT.100879141 DT.121211914 DT.100879135 DT.92460697 DT.95263523 DT.97797745 DT.100879140 DT.121211758

DT.121211837 DT.121211855 DT.121211931 DT.95362804 DT.100879146 DT.306590 DT.75191851 DT.99964048

24/540 AceView cDNA sequences (see all 540):

R20783 AA946744 AA370732 BM676134 CB857921 CF272364 AA351479 AA011089

BU675906 BM874369 AA149794 AA055315 AA831237 F10946 BM905726 AA055314

AA594361 AK090889 AA830236 CA445069 AI929543 CB155283 BE222207 AI497730

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for RAB14 (see all 6) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3a	·	3b	^	4	^	5a	·	5b	^	6	^	7
SP1:													-
SP2:													-		-
SP3:
SP4:
SP5:													-

ECgene alternative splicing isoforms for RAB14

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RAB14 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACCTGCTGGT

About this image

RAB14 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Endocardium

Endocardial Tube Cells

Endocardium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See RAB14 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RAB14

SOURCE GeneReport for Unigene cluster: Hs.371563

SABiosciences Custom PCR Arrays for RAB14

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAB14

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB14

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for RAB14 gene from 6/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	RAB14¹	RAB14, member RAS oncogene family	89.46(n) 100(a)		417119 NM_001012796.1 NP_001012814.1
lizard (Anolis carolinensis)	Reptilia	RAB14⁶	--	100(a)	1 ↔ 1	AAWZ02036218(9955-18341)
African clawed frog (Xenopus laevis)	Amphibia	Xl.8480²	Xenopus laevis transcribed sequence with strong similarity more	84.78(n)		CA971378.1
zebrafish (Danio rerio)	Actinopterygii	Dr.7872²	Danio rerio mRNA similar to RAB14, member RAS oncogene more	80.03(n)		BC045374.1
fruit fly (Drosophila melanogaster)	Insecta	Rab14³	GTP binding	81(a)		35A4 --
worm (Caenorhabditis elegans)	Secernentea	F11A5.4³	RAS related protein	55(a) (best of 2)		V(16198272-16198883) --

ENSEMBL Gene Tree for RAB14 (if available)
TreeFam Gene Tree for RAB14 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RAB14 gene

RAB39A² RAB2A² RAB25² RAB4B² RAB39B² RAB11B² RAB42² RAB4A²

RAB11A² RAB2B²

18/84 SIMAP similar genes for RAB14 using alignment to 1 protein entry: RAB14_HUMAN(see all similar genes):

DKFZp313C1541 RAB4B RAB2A RAB4A RAB2B RAB8B

RAB26 RAB13 RAB17 RAB37 RAB30 RAB11A

RAB10 RAB11B RAB5C RAB15 RAB8A DKFZp686J07132

RAB14 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs181069573^1,2		--	123940464(+)	`TGAACC/TGTTAA`	1	--	ut3¹		0	--	--	--	--
rs79189175^1,2	C,	--	123940477(+)	`TACGGG/TATCAA`	1	--	ut3¹		0	--	--	--	--
rs117504723^1,2	F,	--	123940491(+)	`AGTTAC/AAATAA`	1	--	ut3¹		1		EA	120
rs112997533^1,2	C,	--	123940528(+)	`TACACAGTA/- AGTTC`	1	--	ut3¹		1		CSA	2
rs55905400^1,2	C,F,	--	123940584(+)	`TACATT/CTTTTG`	1	--	ut3¹		1		NA	120
rs75776093^1,2	C,F,	--	123940593(+)	`TGTTTC/AAAGTC`	1	--	ut3¹		1		WA	118
rs56335605^1,2	C,F,	--	123940652(+)	`TCTGGG/AACACA`	1	--	ut3¹		3		WA NA EA	358
rs71718269^1,2	C,	--	123940764(+)	`TTTGG-/TCTTT TCTTC`	1	--	ut3¹		0	--	--	--	--
rs75437105^1,2	C,F,	--	123940778(+)	`CTGTTT/CAGGGG`	1	--	ut3¹		1		WA	118
rs76876933^1,2	C,F,	--	123940796(+)	`TGAACC/GACTCA`	1	--	ut3¹		7		NA CSA WA EA	366

HapMap Linkage Disequilibrium report for RAB14 (123940415 - 123985292 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RAB14
1 CNV: 59506

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAB14

DNA2.0 Custom Variant and Variant Library Synthesis for RAB14

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RAB14 for disorders           About GeneDecksing

OMIM gene information: 612673    OMIM disorders: --

1 disease for RAB14:    About MalaCards

lung cancer

Export disorders for RAB14 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for RAB14 gene, integrated from 9 sources (see all 42):
(articles sorted by number of sources associating them with RAB14)

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Rab14 and its exchange factor FAM116 link endocytic re cycling and adherens junction stability in migrating cells. (PubMed id 22595670)^{1, 2} Linford A....Barr F.A. (2012)
Structural basis of family-wide Rab GTPase recognition by rabenosyn- 5. (PubMed id 16034420)^{1, 2} Eathiraj S.... Lambright D.G. (2005)
Rab14 is involved in membrane trafficking between the Golgi complex and endosomes. (PubMed id 15004230)^{1, 3} Junutula J.R....Scheller R.H. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)^{1, 2} Humphray S.J.... Dunham I. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)^{1, 2} Hu R.-M.... Chen J.-L. (2000)
Small GTP-binding proteins in human endothelial cells . (PubMed id 9792283)^{1, 3} de Leeuw H.P....Voorberg J. (1998)
Class I Rab11-family interacting proteins are binding targets for the Rab14 GTPase. (PubMed id 19702578)^{1, 9} Kelly E.E....McCaffrey M.W. (2010)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 51552	HGNC: 16524	AceView: RAB14	Ensembl:ENSG00000119396	euGenes: HUgn51552
ECgene: RAB14	H-InvDB: RAB14

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for RAB14	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for RAB14	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for RAB14 gene
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Patent Information for RAB14 gene:
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RAB14, member RAS oncogene family

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RAB14, member RAS oncogene family

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