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RAB13 Gene

protein-coding   GIFtS: 62
GCID: GC01M153954

RAB13, Member RAS Oncogene Family

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RAB13, Member RAS Oncogene Family1 2
Cell Growth-Inhibiting Gene 4 Protein2 3
Growth-Inhibiting Gene 4 Protein2
RAS-Associated Protein RAB132
Ras-Related Protein Rab-132

External Ids:    HGNC: 97621   Entrez Gene: 58722   Ensembl: ENSG000001435457   OMIM: 6026725   UniProtKB: P511533   

Export aliases for RAB13 gene to outside databases

Previous GC identifers: GC01M151770 GC01M149685 GC01M150729 GC01M151170 GC01M150767 GC01M152220 GC01M125316


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RAB13 Gene:
This gene is a member of the Rab family of small G proteins and plays a role in regulating membrane trafficking
between trans-Golgi network (TGN) and recycling endosomes (RE). The encoded protein is involved in the assembly
of tight junctions, which are components of the apical junctional complex (AJC) of epithelial cells. The AJC
plays a role in forming a barrier between luminal contents and the underlying tissue. Additional functions
associated with the protein include endocytic recycling of occludin, regulation of epithelial cell scattering,
neuronal regeneration and regulation of neurite outgrowth. Alternately spliced transcript variants have been
observed for this gene. A pseudogene associated with this gene is located on chromosome 12. (provided by RefSeq,
Jan 2013)

GeneCards Summary for RAB13 Gene:
RAB13 (RAB13, member RAS oncogene family) is a protein-coding gene. GO annotations related to this gene include GTP binding. An important paralog of this gene is RAB10.

UniProtKB/Swiss-Prot: RAB13_HUMAN, P51153
Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of
transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active
GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible
for vesicle formation, movement, tethering and fusion. That Rab is involved in endocytic recycling and regulates
the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin.
Thereby, it regulates the assembly and the activity of tight junctions. Moreover, it may also regulate tight
junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the
activation of the downstream effectors PRKACA and MICALL2 respectively. Through its role in tight junction
assembly, may play a role in the establishment of Sertoli cell barrier. Plays also a role in angiogenesis through
regulation of endothelial cells chemotaxis. Also involved in neurite outgrowth. Has also been proposed to play a
role in post-Golgi membrane trafficking from the TGN to the recycling endosome. Finally, it has been involved in
insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore may play a role
in glucose homeostasis

Gene Wiki entry for RAB13 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the RAB13 gene promoter:
         AP-2gamma   C/EBPalpha   PPAR-gamma1   GCNF-1   AP-2beta   PPAR-gamma2   ZIC2/Zic2   GCNF-2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRAB13 promoter sequence
   Search Chromatin IP Primers for RAB13

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RAB13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.2   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21.2

RAB13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAB13 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M153954:  view genomic region     (about GC identifiers)

Start:
153,954,127 bp from pter      End:
153,958,834 bp from pter
Size:
4,708 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RAB13_HUMAN, P51153 (See protein sequence)
Recommended Name: Ras-related protein Rab-13 precursor  
Size: 203 amino acids; 22774 Da
Subunit: Interacts (GTP-bound form) with MICALL2; competes with RAB8A and is involved in tight junctions assembly.
Interacts (GTP-bound form) with MICALL1. Interacts with PRKACA; downstream effector of RAB13 involved in tight
junction assembly. Interacts with GRB2; may recruit RAB13 to the leading edge of migrating endothelial cells
where it can activate RHOA. Interacts (isoprenylated form) with PDE6D; dissociates RAB13 from membranes.
Interacts with CCDC64B/BICDR2. Interacts with LEPROT and LEPROTL1
Secondary accessions: A8K6B5 D3DV67 Q5U0A6 Q6GPG6 Q96GU4

Explore the universe of human proteins at neXtProt for RAB13: NX_P51153

Explore proteomics data for RAB13 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys71
  • Modification sites at PhosphoSitePlus

  • See RAB13 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001258967.1  NP_002861.1  

    ENSEMBL proteins: 
     ENSP00000357564  
    Reactome Protein details: P51153

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RAB: RAB, member RAS oncogene

    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR003579 Small_GTPase_Rab_type
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry P51153

    ProtoNet protein and cluster: P51153

    1 Blocks protein domain: IPB001806 Transforming protein P21 RAS signature

    UniProtKB/Swiss-Prot: RAB13_HUMAN, P51153
    Similarity: Belongs to the small GTPase superfamily. Rab family


    Find genes that share domains with RAB13           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RAB13_HUMAN, P51153
    Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of
    transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active
    GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible
    for vesicle formation, movement, tethering and fusion. That Rab is involved in endocytic recycling and regulates
    the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin.
    Thereby, it regulates the assembly and the activity of tight junctions. Moreover, it may also regulate tight
    junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the
    activation of the downstream effectors PRKACA and MICALL2 respectively. Through its role in tight junction
    assembly, may play a role in the establishment of Sertoli cell barrier. Plays also a role in angiogenesis through
    regulation of endothelial cells chemotaxis. Also involved in neurite outgrowth. Has also been proposed to play a
    role in post-Golgi membrane trafficking from the TGN to the recycling endosome. Finally, it has been involved in
    insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore may play a role
    in glucose homeostasis
    Enzyme regulation: Rab activation is generally mediated by a guanine exchange factor (GEF), while inactivation
    through hydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP). That Rab may be activated by
    DENND1C, a guanine exchange factor. Activated in response to insulin
    Induction: Up-regulated during osteoclast differentiation

         Genatlas biochemistry entry for RAB13:
    Ras-related small GTPase,component of the junctional complex of polarized epithelial cells,specific regulator of
    vesicular trafficking,cycling between cytosolic and membrane-bound forms under the control of PDE6B,expressed in
    skeletal muscle

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity EXP--
    GO:0005515protein binding IPI16525024
    GO:0005525GTP binding IDA--
    GO:0034236protein kinase A catalytic subunit binding IEA--
         
    Find genes that share ontologies with RAB13           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for RAB13:
     Decreased cilium length after   G0/1 arrest  Increased G1 DNA content  Increased cell size 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for RAB13

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    hsa-miR-650 hsa-miR-374c hsa-miR-629* hsa-miR-655 hsa-miR-19b hsa-miR-194 hsa-miR-3612 hsa-miR-19a
    SwitchGear 3'UTR luciferase reporter plasmidRAB13 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RAB13_HUMAN, P51153: Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle membrane; Lipid-anchor;
    Cytoplasmic side. Cell junction, tight junction. Golgi apparatus, trans-Golgi network membrane. Recycling
    endosome membrane. Cell projection, lamellipodium (By similarity). Cytoplasmic vesicle, secretory vesicle
    membrane (By similarity). Note=Tight junctions or associated with vesicles scattered throughout the cytoplasm in
    cells lacking tight junctions. Relocalizes to the leading edge of lamellipodia in migrating endothelial cells
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol3
    golgi apparatus2
    cytoskeleton1
    endosome1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus ----
    GO:0005737cytoplasm IDA--
    GO:0005794NOT Golgi apparatus IDA18779367
    GO:0005802trans-Golgi network IDA18779367

    Find genes that share ontologies with RAB13           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RAB13 About    
    See pathways by source

    SuperPathContained pathways About
    1Clathrin derived vesicle budding
    Membrane Trafficking0.32
    Translocation of GLUT4 to the Plasma Membrane0.32
    2Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions0.36
    3Tight junction
    Tight junction


    Find genes that share SuperPaths with RAB13           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for RAB13
        Epithelial Tight Junctions


    1 Reactome Pathway for RAB13
        Translocation of GLUT4 to the plasma membrane


    1 Kegg Pathway  (Kegg details for RAB13):
        Tight junction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RAB13
    Interactions:

        GeneGlobe Interaction Network for RAB13

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RAB13 (P511531, 2, 3 ENSP000003575644) via UniProtKB, MINT, STRING, and/or I2D (see all 61)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PDE6DO439241, 2, 3, ENSP000002876004EBI-1780121,EBI-712685 MINT-6825336 MINT-6825347 I2D: score=4 STRING: ENSP00000287600
    ENSG00000258947Q135093, ENSP000003202954I2D: score=1 STRING: ENSP00000320295
    CCDC64BA1A5D93, ENSP000003739984STRING: ENSP00000373998 I2D: score=1 
    SLC2A4P146723, ENSP000003209354I2D: score=1 STRING: ENSP00000320935
    TUBB3Q135093I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process EXP--
    GO:0006886intracellular protein transport ----
    GO:0006913nucleocytoplasmic transport ----
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction IEA--

    Find genes that share ontologies with RAB13           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Tocris compounds for RAB13



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RAB13 gene (2 alternative transcripts): 
    NM_001272038.1  NM_002870.3  

    Unigene Cluster for RAB13:

    RAB13, member RAS oncogene family
    Hs.151536  [show with all ESTs]
    Unigene Representative Sequence: NM_001272038
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368575(uc001fdt.1) ENST00000462680(uc001fdu.1) ENST00000495720
    ENST00000484297
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    Additional mRNA sequence: 

    AF498948.1 AK291580.1 AY423722.1 BC000799.1 BC009227.2 BC073168.1 BC094846.1 BT019700.1 
    BT019701.1 NR_073553.1 X75593.1 

    23 DOTS entries:

    DT.447954  DT.100782988  DT.121436379  DT.121176064  DT.92391355  DT.100030339  DT.100782989  DT.97844584 
    DT.100782992  DT.100817421  DT.102833631  DT.102833632  DT.121436448  DT.121436509  DT.121436538  DT.121436539 
    DT.87002597  DT.91753960  DT.91753962  DT.92333738  DT.100882004  DT.95072479  DT.97860931 

    Selected AceView cDNA sequences (see all 930):

    BU623421 AI024017 BC000499 BM685130 BC073168 BQ066292 CF128616 CK822494 
    BE792140 BE396510 CB108038 BM820800 AI380000 AF498948 BE047730 AI384079 
    CR608719 BQ019234 AA683473 BM768551 BU859923 BM765477 AA896972 CB143317 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RAB13 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCTTTCTTG
    RAB13 Expression
    About this image

    RAB13 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RAB13 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.151536

    UniProtKB/Swiss-Prot: RAB13_HUMAN, P51153
    Tissue specificity: Detected in several types of epithelia, including intestine, kidney, liver and in endothelial
    cells

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RAB13 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rab131 , 5 RAB13, member RAS oncogene family1, 5 90.43(n)1
    92.08(a)1
      3 (39.21 cM)5
    683281  NM_026677.31  NP_080953.11 
     902136955 
    chicken
    (Gallus gallus)
    Aves RAB136
    RAB13, member RAS oncogene family
    47(a)
    1 ↔ 1
    2(106217640-106331401)
    lizard
    (Anolis carolinensis)
    Reptilia aca-mir-54056
    aca-mir-5405
    44(a)
    1 → many
    GL343207.1(3218984-3271191)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.61082 Xenopus laevis transcribed sequence with moderate similarity more 79.56(n)    BG816114.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rab132 RAB13, member RAS oncogene family 77.14(n)   373105  BC053195.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rab83 RAB small monomeric GTPase 64(a)
    (best of 4)
      76D2   --


    ENSEMBL Gene Tree for RAB13 (if available)
    TreeFam Gene Tree for RAB13 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RAB13 gene
    RAB102  RAB3B2  RAB262  RAB8A2  RAB3D2  RAB372  RAB3A2  RAB8B2  
    RAB1B2  RAB122  RAB1A2  RAB3C2  
    Selected SIMAP similar genes for RAB13 using alignment to 2 protein entries:     RAB13_HUMAN (see all proteins) (see all similar genes):
    RAB8B    RAB10    DKFZp686J06205    RAB3A    RAB8A    rab1b
    RAB15    RAB3C    RAB1C    RAB3B    DKFZp313C1541    RAB2B
    DKFZp686J07132    RAB11A    RAB12    RAB30    RAB19    RAB26

    Find genes that share paralogs with RAB13           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RAB13 (see all 151)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1830712851,2
    --153953625(+) TGAATA/CAATAA 3 -- ds50010--------
    rs1474962321,2
    C--153954028(+) AAACCC/GAGCCT 3 -- ds50010--------
    rs1400637581,2
    --153954392(+) CCCTTC/TTCCCT 3 -- ut31 nc-transcript-variant0--------
    rs22303241,2
    C,F--153954646(-) GAAACA/C/GGCAAC 8 S R G mis17MN NS NA CSA EU 6050
    rs109085781,2
    C,F,A,H--153954674(+) ACAGGC/TGTCAT 3 -- int127Minor allele frequency- T:0.31NA NS EA WA CSA 2535
    rs2005147341,2
    C--153954681(+) TCATGA/GTGTGA 3 -- int10--------
    rs1887590701,2
    --153954762(+) CTCCCC/TGTTTT 3 -- int10--------
    rs715841581,2
    C--153954779(+) CACCAACAC/-  
            
    ACACA
    3 -- int11Minor allele frequency- -:0.50NA 2
    rs3716256591,2
    C--153954779(+) CACCA-/ACACACA 3 -- int10--------
    rs2013381051,2
    C--153954820(+) ATACAC/TACACA 3 -- int10--------

    HapMap Linkage Disequilibrium report for RAB13 (153954127 - 153958834 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for RAB13: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RAB13
    DNA2.0 Custom Variant and Variant Library Synthesis for RAB13

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602672    OMIM disorders: --


    Find genes that share disorders with RAB13           About GenesLikeMe


    Export disorders for RAB13 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RAB13 gene, integrated from 10 sources (see all 41):
    (articles sorted by number of sources associating them with RAB13)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A small rab GTPase is distributed in cytoplasmic vesicles in non polarized cells but colocalizes with the tight junction marker ZO-1 in polarized epithelial cells. (PubMed id 8294494)1, 2, 3, 9 Zahraoui A.... Louvard D. (J. Cell Biol. 1994)
    2. Rab13 is upregulated during osteoclast differentiation and associates with small vesicles revealing polarized distribution in resorbing cells. (PubMed id 22562557)1, 2 Hirvonen M.J....VAoAonAonen H.K. (J. Histochem. Cytochem. 2012)
    3. Rab13 regulates membrane trafficking between TGN and recycling endosomes in polarized epithelial cells. (PubMed id 18779367)1, 2 Nokes R.L....FAPlsch H. (J. Cell Biol. 2008)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    5. JRAB/MICAL-L2 is a junctional Rab13-binding protein mediating the endocytic recycling of occludin. (PubMed id 16525024)1, 2 Terai T....Sasaki T. (Mol. Biol. Cell 2006)
    6. Rab13 mediates the continuous endocytic recycling of occludin to the cell surface. (PubMed id 15528189)1, 2 Morimoto S....Sasaki T. (J. Biol. Chem. 2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Rab13 regulates PKA signaling during tight junction assembly. (PubMed id 15096524)1, 2 KAPhler K....Zahraoui A. (J. Cell Biol. 2004)
    10. The small GTPase Rab13 regulates assembly of functional tight junctions in epithelial cells. (PubMed id 12058051)1, 2 Marzesco A.M....Zahraoui A. (Mol. Biol. Cell 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5872 HGNC: 9762 AceView: RAB13andJTB Ensembl:ENSG00000143545 euGenes: HUgn5872
    ECgene: RAB13 Kegg: 5872 H-InvDB: RAB13

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RAB13 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAB13 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RAB13 gene:
    Search GeneIP for patents involving RAB13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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