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RAB13 Gene

protein-coding   GIFtS: 63

GC01M152220
RAB13, member RAS oncogene family
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
GIG4 2
OTTHUMP00000034758 2
Descriptions
Cell growth-inhibiting gene 4 protein 3
RAB13, member RAS oncogene family 2
RAS-associated protein RAB13 2
growth-inhibiting gene 4 protein 2
External Ids
HGNC: 97621
Entrez Gene: 58722
UniProtKB: P511533
Ensembl: ENSG000001435457
Search outside databases for aliases for RAB13 gene

Previous GC identifers: GC01M151770 GC01M149685 GC01M150729 GC01M151170 GC01M150767

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: RAB13_HUMAN, P51153
Function: Could participate in polarized transport, in the assembly and/or the activity of tight
junctions

Gene Wiki entry for RAB13

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the RAB13 gene  

Entrez Gene cytogenetic band: 1q21.2   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21.2

RAB13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M152220:     (about GC identifiers)

Start:
152,220,751 bp from pter
End:
152,225,430 bp from pter
Size:
4,680 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000001.9  NT_004487.18  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: RAB13_HUMAN, P51153 (See protein sequence)
Recommended Name: Ras-related protein Rab-13  
Size: 203 amino acids; 22774 Da
Subcellular location: Cell junction, tight junction. Cell membrane; Lipid-anchor; Cytoplasmic side.
Cytoplasmic vesicle membrane; Lipid-anchor; Cytoplasmic side. Note=Cytoplasmic tight junctions or
associated with vesicles scattered throughout the cytoplasm in cells lacking tight junctions
Secondary accessions: A8K6B5 Q5U0A6 Q6GPG6 Q96GU4

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_002861.1  

    ENSEMBL proteins: 
    ENSP00000357564 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (RAB13)
    Human Recombinant Proteins from Abnova (RAB13)
                  OriGene Purified Recombinant Human Protein: RAB13 

    5/7 Gene Ontology (GO) cellular component terms (links to tree view) (see all 7 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737 cytoplasm IDA18029348
    GO:0005794 Golgi apparatus IEA--
    GO:0005886 plasma membrane IEA--
    GO:0005911 cell-cell junction IEA--
    GO:0005923 tight junction TAS8294494
    About this table

    Antibodies for RAB13: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for RAB13
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (RAB13), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (RAB13)
    Novus Biologicals Antibodies for RAB13

    Assays for RAB13: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    4 InterPro domains/families:
     IPR001806 Ras_GTPase
     IPR005225 Small_GTP_bd
     IPR003579 GTPase_Rab
     IPR013753 Ras


       GeneDecks  RAB13 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P51153

    ProtoNet protein and cluster: P51153

    1 Blocks protein family: IPB001806 Transforming protein P21 RAS signature

    UniProtKB/Swiss-Prot: RAB13_HUMAN, P51153
    Similarity: Belongs to the small GTPase superfamily. Rab family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (RAB13)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (RAB13)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002870

                  Applied Biosystems Silencer® siRNAs for RAB13

                  Sigma-Aldrich siRNA for RAB13  
                         Sigma-Aldrich shRNA Panels and shRNA for RAB13  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for RAB13
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_002870
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_002870
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_002870 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_002870

    UniProtKB/Swiss-Prot: RAB13_HUMAN, P51153
    Function: Could participate in polarized transport, in the assembly and/or the activity of tight
    junctions

    Genatlas biochemistry entry for RAB13:
    Ras-related small GTPase,component of the junctional complex of polarized epithelial cells,specific
    regulator of vesicular trafficking,cycling between cytosolic and membrane-bound forms under the
    control of PDE6B,expressed in skeletal muscle

    3 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0003924 GTPase activity TAS8294494
    GO:0005525 GTP binding IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    1 Sigma-Aldrich "Your Favorite Gene" Pathway for  RAB13  (Your Favorite Gene powered by Ingenuity) 
     Tight Junction Signaling

       GeneDecks  RAB13 for the pathways selected above  
    About GeneDecksing

    1 Kegg Pathway  (Kegg details for RAB13):
     hsa04530 Tight junction

       GeneDecks  RAB13 for the pathways selected above  
    About GeneDecksing
     Gene Network CentralTM Interacting Genes and Proteins Network for  RAB13 


    4 Interacting proteins for RAB13 (P511532 ENSP000003575643) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PDE6DO439242MINT-6825336 MINT-6825347
    TJP1ENSP000002815373STRING (score=.781)
    OCLNENSP000003473793STRING (score=.74)
    NEDD9ENSP000003687593STRING (score=.734)
    About this table

    4 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155 cell adhesion TAS8294494
    GO:0007264 small GTPase mediated signal transduction IEA--
    GO:0015031 protein transport IEA--
    GO:0016192 vesicle-mediated transport TAS8294494
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Enzo Life Sciences drugs & compounds for RAB13
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for RAB13

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (RAB13)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (RAB13)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002870

                  Sigma-Aldrich siRNA for RAB13  
                         Sigma-Aldrich shRNA Panels and shRNA for RAB13  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_002870  

    REFSEQ mRNAs for RAB13 gene: 

    NM_002870.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_002870  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_002870
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_002870
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_002870 

    Additional cDNA sequence: 

    AF498948.1 AK128675.1 AK291580.1 AY423722.1 BC000799.1 BC009227.2 BC073168.1 BC094846.1 
    BT019700.1 BT019701.1 CR610750.1 CR612138.1 CR614708.1 X75593.1 

    22 DOTS entries:

    DT.447954  DT.100782988  DT.121436379  DT.121176064  DT.92391355  DT.95072479  DT.100030339  DT.100782989 
    DT.97844584  DT.100782992  DT.100817421  DT.102833631  DT.102833632  DT.121436448  DT.121436509  DT.121436538 
    DT.121436539  DT.87002597  DT.91753960  DT.91753962  DT.92333738  DT.97860931 

    24/930 AceView cDNA sequences (see all 930 ):

    CB160321 BU689274 AI032032 AI568647 AI571667 CB148747 T30169 BM887740 
    CB991161 BQ027177 CA310680 BC004239 BM997537 BU173893 BE267959 BM555992 
    BM312894 AW248680 BU944604 BE792677 BE890968 BI835067 CA777260 BM820241 

    highest scoring ESTs for RAB13:

    X75593 AA296394 AA545802 AA970570 AF498948 AI079191 AK128675 AL519821 AL570891 AU123205 

    Unigene Cluster for RAB13:

    RAB13, member RAS oncogene family
    Hs.151536  [show with all ESTs]
    Unigene Representative Sequence: AK128675


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000368575  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    RAB13 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for RAB13

    1 / 2 / 3

    4 probe-sets matching RAB13 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    40210_at2, 3 U95-A 2 1.00 0.84 0.98 0.89 X75593 1.00 0.90 0.95 1

    73014_s_at2, 3 U95-E 3 1.00 0.81 0.97 1.11 AW001549 0.80 0.88 0.84 1

    202252_at2, 3 U133-A 2 1.00 0.86 -- -- NM_002870 0.60 0.83 0.73 1

    202252_at2 U133Plus2 2 1.00 0.86 -- -- -- -- -- -- --
    GeneDecks  RAB13 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GTCTTTCTTG

    SOURCE GeneReport for Unigene cluster: Hs.151536

    Expression variation in blood from EXPOLDB for RAB13

    UniProtKB/Swiss-Prot: RAB13_HUMAN, P51153
    Tissue specificity: Detected in several types of epithelia, including intestine, kidney, liver and
    in endothelial cells

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for RAB13 gene from 5/7 species (see all 7 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    cow
    (Bos taurus)
    RAB131   -- RAB13, member RAS oncogene family 94.06(n)
    98.02(a)
    514541  NM_001024540.1  NP_001019711.1 
    rat
    (Rattus norvegicus)
    Rab131   -- RAB13, member RAS oncogene family 91.13(n)
    92.61(a)
    81756  NM_031092.1  NP_112354.1 
    mouse
    (Mus musculus)
    Rab131, 5 3 (45.00 cM)5
    RAB13, member RAS oncogene family1, 5 90.43(n)1
    92.08(a)1
    683281  NM_026677.21  NP_080953.11 
     AB2326085  AK0023035  (see all 10)
    zebrafish
    (Danio rerio)
    rab132   -- RAB13, member RAS oncogene family 77.14(n) 373105  BC053195.1 
    fruit fly
    (Drosophila melanogaster)
    Rab83 76D2 RAB small monomeric GTPase 64(a)
    (best of 4)
      --
    About this table        Species with no ortholog for RAB13

    ENSEMBL Gene Tree for RAB13
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for RAB13 gene
    RAB1B2  RAB1A2  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/24 NCBI SNPs in RAB13 are shown (see all 24 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 17)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 1 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    --
    rs112647961,2
    C,H152226754(+) ATTATC/TTAAGA 1 -- ng314Minor allele frequency- T:0.00EU EA WA 414
    rs22754811,2
    C,H152225242(+) TGAAGT/CTGTCC 1 S/N mis15Minor allele frequency- C:0.01EA EU WA 1900
    --
    rs168357031,2
    F152225730(-) AATTTC/GTCTTC 1 -- ng31 trp32Minor allele frequency- G:0.01MN EA 356
    rs109085781,2
    A,C,F,H152221298(+) ACAGGC/TGTCAT 1 -- int110Minor allele frequency- T:0.31EU EA WA NA 1014
    rs120335751,2
    H152224197(+) AATTCA/TGTCTC 1 -- int14Minor allele frequency- T:0.00EU EA WA 416
    --
    rs38384851,2
    C152224824(-) CCGAT-/CCGCTAG 1 -- int10--------
    --
    rs715841591,2
    --152226320(+) GAAAC-/AAGTTT 1 -- ng310--------
    --
    rs352227551,2
    --152226629(+) AAAAA-/AAAG  
            
    AAGAA
    1 -- ng310--------
    --
    rs726336431,2
    --152226088(+) AGACAC/TATCCT 1 -- ng310--------
    --
    rs354285791,2
    --152226075(+) CACAG-/TCCTAC 1 -- ng310--------
    About this table

    HapMap Linkage Disequilibrium images for RAB13 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 602672

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/20 PubMed articles for RAB13 gene (see all 20 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 5872 HGNC: 9762 AceView: RAB13andJTB Ensembl:ENSG00000143545 euGenes: HUgn5872
    ECgene: RAB13 H-InvDB: RAB13
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for RAB13 Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for RAB13:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Predesigned and custom siRNAs for RAB13 Antibodies for RAB13
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for RAB13 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant Proteins
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     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     Search Tocris compounds for RAB13




     Drugs for RAB13
     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for RAB13

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