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Aliases for RAB13 Gene

Aliases for RAB13 Gene

  • RAB13, Member RAS Oncogene Family 2 3 5
  • Cell Growth-Inhibiting Gene 4 Protein 3 4
  • Growth-Inhibiting Gene 4 Protein 3
  • RAS-Associated Protein RAB13 3
  • GIG4 3

External Ids for RAB13 Gene

Previous GeneCards Identifiers for RAB13 Gene

  • GC01M151770
  • GC01M149685
  • GC01M150729
  • GC01M151170
  • GC01M150767
  • GC01M152220
  • GC01M153954
  • GC01M125316

Summaries for RAB13 Gene

Entrez Gene Summary for RAB13 Gene

  • This gene is a member of the Rab family of small G proteins and plays a role in regulating membrane trafficking between trans-Golgi network (TGN) and recycling endosomes (RE). The encoded protein is involved in the assembly of tight junctions, which are components of the apical junctional complex (AJC) of epithelial cells. The AJC plays a role in forming a barrier between luminal contents and the underlying tissue. Additional functions associated with the protein include endocytic recycling of occludin, regulation of epithelial cell scattering, neuronal regeneration and regulation of neurite outgrowth. Alternately spliced transcript variants have been observed for this gene. A pseudogene associated with this gene is located on chromosome 12. [provided by RefSeq, Jan 2013]

GeneCards Summary for RAB13 Gene

RAB13 (RAB13, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Tight junction. GO annotations related to this gene include GTP binding and protein kinase A catalytic subunit binding. An important paralog of this gene is RAB37.

UniProtKB/Swiss-Prot for RAB13 Gene

  • The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regulates the assembly and the activity of tight junctions. Moreover, it may also regulate tight junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the activation of the downstream effectors PRKACA and MICALL2 respectively. Through its role in tight junction assembly, may play a role in the establishment of Sertoli cell barrier. Plays also a role in angiogenesis through regulation of endothelial cells chemotaxis. Also involved in neurite outgrowth. Has also been proposed to play a role in post-Golgi membrane trafficking from the TGN to the recycling endosome. Finally, it has been involved in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore may play a role in glucose homeostasis.

Gene Wiki entry for RAB13 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB13 Gene

Genomics for RAB13 Gene

Regulatory Elements for RAB13 Gene

Promoters for RAB13 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RAB13 on UCSC Golden Path with GeneCards custom track

Genomic Location for RAB13 Gene

Chromosome:
1
Start:
153,981,617 bp from pter
End:
153,986,377 bp from pter
Size:
4,761 bases
Orientation:
Minus strand

Genomic View for RAB13 Gene

Genes around RAB13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB13 Gene

Proteins for RAB13 Gene

  • Protein details for RAB13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51153-RAB13_HUMAN
    Recommended name:
    Ras-related protein Rab-13
    Protein Accession:
    P51153
    Secondary Accessions:
    • A8K6B5
    • D3DV67
    • Q5U0A6
    • Q6GPG6
    • Q96GU4

    Protein attributes for RAB13 Gene

    Size:
    203 amino acids
    Molecular mass:
    22774 Da
    Quaternary structure:
    • Interacts (GTP-bound form) with MICALL2; competes with RAB8A and is involved in tight junctions assembly. Interacts (GTP-bound form) with MICALL1. Interacts with PRKACA; downstream effector of RAB13 involved in tight junction assembly. Interacts with GRB2; may recruit RAB13 to the leading edge of migrating endothelial cells where it can activate RHOA. Interacts (isoprenylated form) with PDE6D; dissociates RAB13 from membranes. Interacts with CCDC64B/BICDR2. Interacts with LEPROT and LEPROTL1.

neXtProt entry for RAB13 Gene

Proteomics data for RAB13 Gene at MOPED

Post-translational modifications for RAB13 Gene

  • Ubiquitination at Lys 71
  • Modification sites at PhosphoSitePlus

Other Protein References for RAB13 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RAB13 Gene

Domains & Families for RAB13 Gene

Gene Families for RAB13 Gene

Suggested Antigen Peptide Sequences for RAB13 Gene

Graphical View of Domain Structure for InterPro Entry

P51153

UniProtKB/Swiss-Prot:

RAB13_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB13: view

Function for RAB13 Gene

Molecular function for RAB13 Gene

GENATLAS Biochemistry:
Ras-related small GTPase,component of the junctional complex of polarized epithelial cells,specific regulator of vesicular trafficking,cycling between cytosolic and membrane-bound forms under the control of PDE6B,expressed in skeletal muscle
UniProtKB/Swiss-Prot EnzymeRegulation:
Rab activation is generally mediated by a guanine exchange factor (GEF), while inactivation through hydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP). That Rab may be activated by DENND1C, a guanine exchange factor. Activated in response to insulin.
UniProtKB/Swiss-Prot Function:
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regulates the assembly and the activity of tight junctions. Moreover, it may also regulate tight junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the activation of the downstream effectors PRKACA and MICALL2 respectively. Through its role in tight junction assembly, may play a role in the establishment of Sertoli cell barrier. Plays also a role in angiogenesis through regulation of endothelial cells chemotaxis. Also involved in neurite outgrowth. Has also been proposed to play a role in post-Golgi membrane trafficking from the TGN to the recycling endosome. Finally, it has been involved in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore may play a role in glucose homeostasis.
UniProtKB/Swiss-Prot Induction:
Up-regulated during osteoclast differentiation.
genes like me logo Genes that share phenotypes with RAB13: view

Animal Model Products

miRNA for RAB13 Gene

miRTarBase miRNAs that target RAB13

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB13 Gene

Localization for RAB13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB13 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle membrane; Lipid-anchor; Cytoplasmic side. Cell junction, tight junction. Golgi apparatus, trans-Golgi network membrane. Recycling endosome membrane. Cell projection, lamellipodium. Note=Tight junctions or associated with vesicles scattered throughout the cytoplasm in cells lacking tight junctions (PubMed:8294494). Relocalizes to the leading edge of lamellipodia in migrating endothelial cells (By similarity). {ECO:0000250 UniProtKB:Q9DD03, ECO:0000269 PubMed:8294494}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB13 Gene COMPARTMENTS Subcellular localization image for RAB13 gene
Compartment Confidence
endosome 5
extracellular 5
golgi apparatus 5
plasma membrane 5
cytosol 4
cytoskeleton 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RAB13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005923 bicellular tight junction IEA,IDA 8294494
GO:0030658 transport vesicle membrane IEA --
GO:0030659 cytoplasmic vesicle membrane TAS --
GO:0032593 insulin-responsive compartment IEA,ISS --
genes like me logo Genes that share ontologies with RAB13: view

Pathways & Interactions for RAB13 Gene

genes like me logo Genes that share pathways with RAB13: view

Pathways by source for RAB13 Gene

1 KEGG pathway for RAB13 Gene
1 Qiagen pathway for RAB13 Gene

Gene Ontology (GO) - Biological Process for RAB13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IEA --
GO:0006904 vesicle docking involved in exocytosis IBA --
GO:0007165 signal transduction IEA --
GO:0009306 protein secretion IBA --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with RAB13: view

No data available for SIGNOR curated interactions for RAB13 Gene

Drugs & Compounds for RAB13 Gene

No Compound Related Data Available

Transcripts for RAB13 Gene

Unigene Clusters for RAB13 Gene

RAB13, member RAS oncogene family:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB13 Gene

No ASD Table

Relevant External Links for RAB13 Gene

GeneLoc Exon Structure for
RAB13
ECgene alternative splicing isoforms for
RAB13

Expression for RAB13 Gene

mRNA expression in normal human tissues for RAB13 Gene

Protein differential expression in normal tissues from HIPED for RAB13 Gene

This gene is overexpressed in Nasal epithelium (22.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB13 Gene



SOURCE GeneReport for Unigene cluster for RAB13 Gene Hs.151536

mRNA Expression by UniProt/SwissProt for RAB13 Gene

P51153-RAB13_HUMAN
Tissue specificity: Detected in several types of epithelia, including intestine, kidney, liver and in endothelial cells.
genes like me logo Genes that share expression patterns with RAB13: view

Protein tissue co-expression partners for RAB13 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RAB13 Gene

Orthologs for RAB13 Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB13 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RAB13 35
  • 93.92 (n)
  • 97.54 (a)
RAB13 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAB13 35
  • 89.82 (n)
  • 95.07 (a)
RAB13 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rab13 35
  • 90.43 (n)
  • 92.08 (a)
Rab13 16
Rab13 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RAB13 35
  • 99.67 (n)
  • 100 (a)
RAB13 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rab13 35
  • 91.13 (n)
  • 92.61 (a)
oppossum
(Monodelphis domestica)
Mammalia RAB13 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAB13 36
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-5405 36
  • 44 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC97787 35
  • 73.33 (n)
  • 83 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6108 35
zebrafish
(Danio rerio)
Actinopterygii rab13 35
  • 69.01 (n)
  • 79.4 (a)
rab13 36
  • 79 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG2885 37
  • 50 (a)
Rab-RP3 37
  • 47 (a)
Rab10 37
  • 63 (a)
Rab8 37
  • 64 (a)
RabX4 36
  • 44 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea 4R79.2 37
  • 40 (a)
C33D12.6 37
  • 38 (a)
rab-8 37
  • 64 (a)
Species with no ortholog for RAB13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB13 Gene

ENSEMBL:
Gene Tree for RAB13 (if available)
TreeFam:
Gene Tree for RAB13 (if available)

Paralogs for RAB13 Gene

genes like me logo Genes that share paralogs with RAB13: view

Variants for RAB13 Gene

Sequence variations from dbSNP and Humsavar for RAB13 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2230324 -- 153,982,170(-) GAAAC(A/C/G)GCAAC nc-transcript-variant, reference, missense
rs2275481 -- 153,986,142(+) TGAAG(C/T)TGTCC nc-transcript-variant, upstream-variant-2KB, reference, missense
rs3838485 -- 153,985,724(-) CCGAT(-/CC)GCTAG intron-variant, upstream-variant-2KB
rs10908578 -- 153,982,198(+) ACAGG(C/T)GTCAT intron-variant
rs11264796 -- 153,987,654(+) ATTAT(C/T)TAAGA upstream-variant-2KB

Variation tolerance for RAB13 Gene

Residual Variation Intolerance Score: 66.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.24; 40.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAB13 Gene

HapMap Linkage Disequilibrium report
RAB13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RAB13 Gene

Disorders for RAB13 Gene

Relevant External Links for RAB13

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAB13

No disorders were found for RAB13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB13 Gene

Publications for RAB13 Gene

  1. A small rab GTPase is distributed in cytoplasmic vesicles in non polarized cells but colocalizes with the tight junction marker ZO-1 in polarized epithelial cells. (PMID: 8294494) Zahraoui A. … Louvard D. (J. Cell Biol. 1994) 2 3 4 23 67
  2. DENND2B activates Rab13 at the leading edge of migrating cells and promotes metastatic behavior. (PMID: 25713415) Ioannou M.S. … McPherson P.S. (J. Cell Biol. 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry. (PMID: 24332808) Marechal A. … Zou L. (Mol. Cell 2014) 3
  5. Novel interaction of Rab13 and Rab8 with endospanins. (PMID: 23772379) Hirvonen M.J. … VAoAonAonen K.H. (FEBS Open Bio 2013) 3

Products for RAB13 Gene

Sources for RAB13 Gene

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