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Aliases for RAB13 Gene

Aliases for RAB13 Gene

  • RAB13, Member RAS Oncogene Family 2 3
  • Cell Growth-Inhibiting Gene 4 Protein 3 4
  • Growth-Inhibiting Gene 4 Protein 3
  • RAS-Associated Protein RAB13 3
  • Ras-Related Protein Rab-13 3
  • GIG4 3

External Ids for RAB13 Gene

Previous GeneCards Identifiers for RAB13 Gene

  • GC01M151770
  • GC01M149685
  • GC01M150729
  • GC01M151170
  • GC01M150767
  • GC01M152220
  • GC01M153954
  • GC01M125316

Summaries for RAB13 Gene

Entrez Gene Summary for RAB13 Gene

  • This gene is a member of the Rab family of small G proteins and plays a role in regulating membrane trafficking between trans-Golgi network (TGN) and recycling endosomes (RE). The encoded protein is involved in the assembly of tight junctions, which are components of the apical junctional complex (AJC) of epithelial cells. The AJC plays a role in forming a barrier between luminal contents and the underlying tissue. Additional functions associated with the protein include endocytic recycling of occludin, regulation of epithelial cell scattering, neuronal regeneration and regulation of neurite outgrowth. Alternately spliced transcript variants have been observed for this gene. A pseudogene associated with this gene is located on chromosome 12. [provided by RefSeq, Jan 2013]

GeneCards Summary for RAB13 Gene

RAB13 (RAB13, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Clathrin derived vesicle budding and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include GTP binding. An important paralog of this gene is RAB37.

UniProtKB/Swiss-Prot for RAB13 Gene

  • The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regulates the assembly and the activity of tight junctions. Moreover, it may also regulate tight junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the activation of the downstream effectors PRKACA and MICALL2 respectively. Through its role in tight junction assembly, may play a role in the establishment of Sertoli cell barrier. Plays also a role in angiogenesis through regulation of endothelial cells chemotaxis. Also involved in neurite outgrowth. Has also been proposed to play a role in post-Golgi membrane trafficking from the TGN to the recycling endosome. Finally, it has been involved in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore may play a role in glucose homeostasis.

Gene Wiki entry for RAB13 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB13 Gene

Genomics for RAB13 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RAB13 Gene

Start:
153,981,617 bp from pter
End:
153,986,377 bp from pter
Size:
4,761 bases
Orientation:
Minus strand

Genomic View for RAB13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAB13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB13 Gene

Proteins for RAB13 Gene

  • Protein details for RAB13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51153-RAB13_HUMAN
    Recommended name:
    Ras-related protein Rab-13
    Protein Accession:
    P51153
    Secondary Accessions:
    • A8K6B5
    • D3DV67
    • Q5U0A6
    • Q6GPG6
    • Q96GU4

    Protein attributes for RAB13 Gene

    Size:
    203 amino acids
    Molecular mass:
    22774 Da
    Quaternary structure:
    • Interacts (GTP-bound form) with MICALL2; competes with RAB8A and is involved in tight junctions assembly. Interacts (GTP-bound form) with MICALL1. Interacts with PRKACA; downstream effector of RAB13 involved in tight junction assembly. Interacts with GRB2; may recruit RAB13 to the leading edge of migrating endothelial cells where it can activate RHOA. Interacts (isoprenylated form) with PDE6D; dissociates RAB13 from membranes. Interacts with CCDC64B/BICDR2. Interacts with LEPROT and LEPROTL1.

neXtProt entry for RAB13 Gene

Proteomics data for RAB13 Gene at MOPED

Post-translational modifications for RAB13 Gene

  • Ubiquitination at Lys71
  • Modification sites at PhosphoSitePlus

Other Protein References for RAB13 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RAB13 Gene

Domains for RAB13 Gene

Gene Families for RAB13 Gene

HGNC:
  • RAB :RAB, member RAS oncogene

Suggested Antigen Peptide Sequences for RAB13 Gene

Graphical View of Domain Structure for InterPro Entry

P51153

UniProtKB/Swiss-Prot:

RAB13_HUMAN :
  • P51153
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB13: view

Function for RAB13 Gene

Molecular function for RAB13 Gene

GENATLAS Biochemistry: Ras-related small GTPase,component of the junctional complex of polarized epithelial cells,specific regulator of vesicular trafficking,cycling between cytosolic and membrane-bound forms under the control of PDE6B,expressed in skeletal muscle
UniProtKB/Swiss-Prot EnzymeRegulation: Rab activation is generally mediated by a guanine exchange factor (GEF), while inactivation through hydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP). That Rab may be activated by DENND1C, a guanine exchange factor. Activated in response to insulin.
UniProtKB/Swiss-Prot Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regulates the assembly and the activity of tight junctions. Moreover, it may also regulate tight junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the activation of the downstream effectors PRKACA and MICALL2 respectively. Through its role in tight junction assembly, may play a role in the establishment of Sertoli cell barrier. Plays also a role in angiogenesis through regulation of endothelial cells chemotaxis. Also involved in neurite outgrowth. Has also been proposed to play a role in post-Golgi membrane trafficking from the TGN to the recycling endosome. Finally, it has been involved in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore may play a role in glucose homeostasis.
UniProtKB/Swiss-Prot Induction: Up-regulated during osteoclast differentiation.

Gene Ontology (GO) - Molecular Function for RAB13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IBA --
GO:0005515 protein binding IPI 16525024
GO:0005525 GTP binding IDA 20937701
GO:0034236 protein kinase A catalytic subunit binding IEA --
genes like me logo Genes that share ontologies with RAB13: view

Phenotypes for RAB13 Gene

genes like me logo Genes that share phenotypes with RAB13: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RAB13 Gene

Localization for RAB13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB13 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle membrane; Lipid-anchor; Cytoplasmic side. Cell junction, tight junction. Golgi apparatus, trans-Golgi network membrane. Recycling endosome membrane. Cell projection, lamellipodium. Cytoplasmic vesicle, secretory vesicle membrane. Note=Tight junctions or associated with vesicles scattered throughout the cytoplasm in cells lacking tight junctions. Relocalizes to the leading edge of lamellipodia in migrating endothelial cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB13 Gene COMPARTMENTS Subcellular localization image for RAB13 gene
Compartment Confidence
plasma membrane 5
cytosol 3
golgi apparatus 2
cytoskeleton 1
endosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RAB13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005737 cytoplasm IDA --
GO:0005794 NOT Golgi apparatus IDA 18779367
GO:0005802 trans-Golgi network IDA 18779367
genes like me logo Genes that share ontologies with RAB13: view

Pathways for RAB13 Gene

genes like me logo Genes that share pathways with RAB13: view

Pathways by source for RAB13 Gene

1 Qiagen pathway for RAB13 Gene
1 KEGG pathway for RAB13 Gene

Gene Ontology (GO) - Biological Process for RAB13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport IBA --
GO:0006913 nucleocytoplasmic transport --
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction --
genes like me logo Genes that share ontologies with RAB13: view

Transcripts for RAB13 Gene

Unigene Clusters for RAB13 Gene

RAB13, member RAS oncogene family:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAB13

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB13 Gene

No ASD Table

Relevant External Links for RAB13 Gene

GeneLoc Exon Structure for
RAB13
ECgene alternative splicing isoforms for
RAB13

Expression for RAB13 Gene

mRNA expression in normal human tissues for RAB13 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB13 Gene

SOURCE GeneReport for Unigene cluster for RAB13 Gene Hs.151536

mRNA Expression by UniProt/SwissProt for RAB13 Gene

P51153-RAB13_HUMAN
Tissue specificity: Detected in several types of epithelia, including intestine, kidney, liver and in endothelial cells
genes like me logo Genes that share expressions with RAB13: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RAB13 Gene

Orthologs for RAB13 Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB13 35
  • 99.67 (n)
  • 100 (a)
RAB13 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RAB13 35
  • 93.92 (n)
  • 97.54 (a)
RAB13 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAB13 35
  • 89.82 (n)
  • 95.07 (a)
RAB13 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rab13 35
  • 90.43 (n)
  • 92.08 (a)
Rab13 16
Rab13 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAB13 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rab13 35
  • 91.13 (n)
  • 92.61 (a)
chicken
(Gallus gallus)
Aves RAB13 36
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-5405 36
  • 44 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.6108 35
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC97787 35
  • 73.33 (n)
  • 83 (a)
zebrafish
(Danio rerio)
Actinopterygii rab13 35
  • 69.01 (n)
  • 79.4 (a)
rab13 36
  • 79 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta RabX4 36
  • 44 (a)
OneToOne
CG2885 37
  • 50 (a)
Rab10 37
  • 63 (a)
Rab8 37
  • 64 (a)
Rab-RP3 37
  • 47 (a)
worm
(Caenorhabditis elegans)
Secernentea 4R79.2 37
  • 40 (a)
rab-8 37
  • 64 (a)
C33D12.6 37
  • 38 (a)
Species with no ortholog for RAB13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB13 Gene

ENSEMBL:
Gene Tree for RAB13 (if available)
TreeFam:
Gene Tree for RAB13 (if available)

Paralogs for RAB13 Gene

Paralogs for RAB13 Gene

genes like me logo Genes that share paralogs with RAB13: view

Variants for RAB13 Gene

Sequence variations from dbSNP and Humsavar for RAB13 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2230324 -- 153,982,170(-) GAAAC(A/C/G)GCAAC missense, reference, nc-transcript-variant
rs2275481 -- 153,986,142(+) TGAAG(C/T)TGTCC upstream-variant-2KB, reference, missense, nc-transcript-variant
rs3838485 -- 153,985,724(-) CCGAT(-/CC)GCTAG upstream-variant-2KB, intron-variant
rs10908578 -- 153,982,198(+) ACAGG(C/T)GTCAT intron-variant
rs11264796 -- 153,987,654(+) ATTAT(C/T)TAAGA upstream-variant-2KB

Relevant External Links for RAB13 Gene

HapMap Linkage Disequilibrium report
RAB13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RAB13 Gene

Disorders for RAB13 Gene

No disorders were found for RAB13 Gene.

No data available for UniProtKB/Swiss-Prot for RAB13 Gene

Publications for RAB13 Gene

  1. A small rab GTPase is distributed in cytoplasmic vesicles in non polarized cells but colocalizes with the tight junction marker ZO-1 in polarized epithelial cells. (PMID: 8294494) Zahraoui A. … Louvard D. (J. Cell Biol. 1994) 2 3 4 23
  2. Isoprenylation of Rab proteins possessing a C-terminal CaaX motif. (PMID: 8375503) Joberty G. … Zahraoui A. (FEBS Lett. 1993) 3 4
  3. The rod cGMP phosphodiesterase delta subunit dissociates the small GTPase Rab13 from membranes. (PMID: 9712853) Marzesco A.M. … Zahraoui A. (J. Biol. Chem. 1998) 3 4
  4. The small GTPase Rab13 regulates assembly of functional tight junctions in epithelial cells. (PMID: 12058051) Marzesco A.M. … Zahraoui A. (Mol. Biol. Cell 2002) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for RAB13 Gene

Sources for RAB13 Gene

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