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RAB12 Gene

protein-coding GIFtS: 41

GC18P008600

RAB12, member RAS oncogene family
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
FLJ45927 ^²
MGC104724 ^²

Descriptions
RAB12, member RAS oncogene family ^²

External Ids
HGNC: 31332¹
Entrez Gene: 201475²
UniProtKB: Q6IQ22³
Ensembl: ENSG00000206418⁷

Search outside databases for aliases for RAB12 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the RAB12 gene

Entrez Gene cytogenetic band: 18p11.22 Ensembl cytogenetic band: 18p11.22 HGNC cytogenetic band: 18p11.22

RAB12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 18 GeneLoc Exon Structure

GeneLoc location for GC18P008600: (about GC identifiers)

Start:	8,599,443 bp from pter
End:	8,629,380 bp from pter
Size:	29,938 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000018.8 NT_010859.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: RAB12_HUMAN, Q6IQ22 (See protein sequence)

Recommended Name: Putative Ras-related protein Rab-12

Size: 244 amino acids; 27248 Da

Subcellular location: Golgi apparatus membrane; Lipid-anchor (By similarity)

Caution: Could be the product of a pseudogene

Sequence caution: Sequence=AAH71600.2; Type=Miscellaneous discrepancy; Note=Intron retention;

Sequence=AAH98407.1; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=BC050338;

Type=Frameshift; Positions=195;

PDB structures from and Proteopedia :

2IL1 (3D)

Secondary accessions: A6NEF5 Q4KMQ3

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001020471.2

ENSEMBL proteins:

ENSP00000331748

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich AQUA Peptides for RAB12
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	IEA	--
GO:0005794	Golgi apparatus	IEA	--
GO:0016020	membrane	IEA	--

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Antibodies for RAB12:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for RAB12

Assays for RAB12:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q6IQ22

ProtoNet protein and cluster: Q6IQ22

UniProtKB/Swiss-Prot: RAB12_HUMAN, Q6IQ22

Similarity: Belongs to the small GTPase superfamily. Rab family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_113967

Applied Biosystems Silencer® siRNAs for RAB12

Sigma-Aldrich siRNA for RAB12

Sigma-Aldrich shRNA for RAB12

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001025300
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001025300
untagged cDNA clones in CMV expression vector (see all 3): NM_001025300

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001025300

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0005525	GTP binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007264	small GTPase mediated signal transduction	IEA	--
GO:0015031	protein transport	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for RAB12

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_113967

Sigma-Aldrich siRNA for RAB12

Sigma-Aldrich shRNA for RAB12

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001025300

REFSEQ mRNAs for RAB12 gene:

NM_001025300.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001025300

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001025300
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001025300
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001025300

Additional cDNA sequence:

AK127824.1 BC050338.1 BC071600.1 BC098407.1 CR627121.1

5 DOTS entries:

DT.108281 DT.97793083 DT.101971256 DT.407758 DT.411259

24/53 AceView cDNA sequences (see all 53 ):

BU754385 AI356332 BQ024519 AI080373 CD518316 BC050338 AA001052 BX493064

BX642232 BX097121 AA001088 BX118866 AI076335 BC071600 AW449532 AW371677

R78438 BQ438719 R02835 AA824235 AA027097 CF994415 BF574430 AA680106

highest scoring ESTs for RAB12:

AI076335 AA401533 AI032693 AI356332 AW170394 AW449532 AW449830 AW452366 AW452854 BC071600

Unigene Cluster for RAB12:

RAB12, member RAS oncogene family

Hs.270074 [show with all ESTs]

Unigene Representative Sequence: BC071600

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000329286

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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RAB12 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for RAB12

¹ / ² / ³

10 probe-sets matching RAB12 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
63414_at²^{, 3}	U95-C	1	1.00	1.00	0.62	0.40	AI076335	0.80	1.00	0.91	1
43226_r_at²^{, 3}	U95-B	1	1.00	1.00	0.84	1.06	AA001052	0.40	1.00	0.76	1
50154_at²^{, 3}	U95-B	1	1.00	1.00	0.93	1.21	N21135	0.40	1.00	0.76	1
43225_i_at²^{, 3}	U95-B	1	1.00	1.00	0.94	1.35	AA001052	0.40	1.00	0.76	1
236019_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI076335	0.80	1.00	0.91	1
239891_x_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AA001052	0.40	1.00	0.76	1
235059_at²^{, 3}	U133-B	2	1.00	0.95	--	--	BF574430	0.20	1.00	0.72	1
236019_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
239891_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
235059_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--

GeneDecks RAB12 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
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About these images

CGAP SAGE TAG: GCTTCCTAAG

SOURCE GeneReport for Unigene cluster: Hs.270074

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for RAB12 gene from 4 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	RAB12¹	--	RAB12, member RAS oncogene family	99.59(n) 100(a)	736838 XM_001140752.1 XP_001140752.1
mouse (Mus musculus)	Rab12^{1, 5}	17⁵	RAB12, member RAS oncogene family^{1, 5}	90.53(n)¹ 96.3(a)¹	19328¹ NM_024448.2¹ NP_077768.2¹ AB232607⁵ AI848325⁵ (see all 19)
zebrafish (Danio rerio)	Dr.15011²	--	Transcribed sequence with weak similarity to protein more	78.24(n)	CK145823.1
tropical clawed frog (Silurana tropicalis)	Str.12902²	--	Transcribed sequence with weak similarity to protein more	84.97(n)	BX733221.1

About this table Species with no ortholog for RAB12

ENSEMBL Gene Tree for RAB12

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for RAB12 gene

RAB3A² RAB3B² RAB3D² RAB3C²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/192 NCBI SNPs in RAB12 are shown (see all 192 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 43)

AB	SNP ID	Valid	Chr 18 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs11662785^1,2	A,C,F,H	8597757(+)	`TGCTAG/CAGGAA`	1	--	ng5¹ trp³		10		EA WA NA	798
--	rs399600^1,2	A,C,F,H	8629516(+)	`tgatgT/Gtttct`	1	--	ng3¹		4		EU EA WA	412
--	rs11661395^1,2	A,C,F	8598508(+)	`CAAGCT/CGAGGA`	1	--	ng5¹		4		EA NA	216
	rs7237512^1,2	A,F,H	8599121(+)	`CCACAC/GTAAGT`	1	--	ng5¹		4		EU EA WA	418
--	rs321662^1,2	C,F,H	8628473(-)	`ACTGGG/AGTAAT`	1	--	ut3¹		11		NA EU EA WA	974
--	rs2726348^1,2	A,H	8629209(-)	`AGTTCA/CCAAAT`	1	--	ut3¹		4		EU EA WA	418
--	rs12963039^1,2	A,H	8629193(+)	`tttGGT/GCTGAT`	1	--	ut3¹		4		EU EA WA	398
--	rs12963196^1,2	H	8629265(+)	`CAAGGT/GAATTA`	1	--	ut3¹		4		EU EA WA	414
--	rs12962081^1,2	A	8598921(+)	`GGCCTC/GAGGTC`	1	--	ng5¹		0	--	--	--	--
--	rs12970639^1,2	C	8599315(+)	`CGCAGC/TACCCA`	1	--	ng5¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for RAB12 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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4 PubMed articles for RAB12 gene:

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)⁴ Dephoure N.... Gygi S.P. (2008)
DNA sequence and analysis of human chromosome 18. (PubMed id 16177791)⁴ Nusbaum C.... Lander E.S. (2005)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 201475	HGNC: 31332	AceView: LOC201475	Ensembl:ENSG00000206418	euGenes: HUgn201475
ECgene: RAB12	H-InvDB: RAB12

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for RAB12	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for RAB12
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for RAB12:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for RAB12-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for RAB12		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Proteins for RAB12
	Lentivirus-delivered shRNAs for RAB12		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Cell Culture Products		ELISAs
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	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Custom Service for Rabbit Pab from Full-length Protein

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Search Tocris compounds for RAB12

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for RAB12

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RAB12 Gene

protein-coding GIFtS: 41

Aliases &
Descriptions
for RAB12

Summaries
for RAB12

Genomic Location
for RAB12

Proteins
for RAB12

Protein Domains/
Families
for RAB12

Gene Function
for RAB12

Pathways & Interactions
for RAB12

Drugs & Compounds
for RAB12

Transcripts
for RAB12

Expression
for RAB12

Orthologs
for RAB12

Paralogs
for RAB12

SNPs/Variants
for RAB12

Disorders & Mutations
for RAB12

Medical News
for RAB12

Publications
for RAB12

Search for RAB12

Genome Databases showing RAB12

Other Databases showing RAB12

Specialized Databases showing RAB12

Licensable Technologies
for RAB12

Services
for RAB12

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

RAB12 Gene

protein-coding GIFtS: 41

Aliases & Descriptionsfor RAB12

Summariesfor RAB12

Genomic Locationfor RAB12

Proteinsfor RAB12

Protein Domains/Familiesfor RAB12

Gene Functionfor RAB12

Pathways & Interactionsfor RAB12

Drugs & Compoundsfor RAB12

Transcriptsfor RAB12

Expression for RAB12

Orthologsfor RAB12

Paralogsfor RAB12

SNPs/Variantsfor RAB12

Disorders & Mutationsfor RAB12

Medical Newsfor RAB12

Publicationsfor RAB12

Search for RAB12

Genome Databases showing RAB12

Other Databases showing RAB12

Specialized Databases showing RAB12

Licensable Technologiesfor RAB12

Servicesfor RAB12

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for RAB12

Summaries
for RAB12

Genomic Location
for RAB12

Proteins
for RAB12

Protein Domains/
Families
for RAB12

Gene Function
for RAB12

Pathways & Interactions
for RAB12

Drugs & Compounds
for RAB12

Transcripts
for RAB12

Expression
for RAB12

Orthologs
for RAB12

Paralogs
for RAB12

SNPs/Variants
for RAB12

Disorders & Mutations
for RAB12

Medical News
for RAB12

Publications
for RAB12

Licensable Technologies
for RAB12

Services
for RAB12