RAB12 Gene
protein-coding GIFtS: 44
GCID: GC18P008600
|
|
RAB12, member RAS oncogene family
| |
Aliases
for RAB12 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| RAB12, Member RAS Oncogene Family1 2 | | Putative Ras-Related Protein Rab-122 | | Ras-Related Protein Rab-122 |
Export aliases for RAB12 gene to outside databases |
Summaries
for RAB12 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: RAB12_HUMAN, Q6IQ22Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation oftransport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an activeGTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible forvesicle formation, movement, tethering and fusion. That Rab may play a role in protein transport from recyclingendosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor (By similarity)
|
Genomic Views
for RAB12 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000018.9 NC_018929.1 NT_010859.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RAB12 gene promoter:
Egr-3 Egr-1 CUTL1 E47 c-Ets-1 RORalpha1 POU2F1 FOXJ2 (long isoform) STAT3 FOXJ2
Other transcription factors
Search SABiosciences Chromatin IP Primers for RAB12
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB12 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 18p11.22 Ensembl cytogenetic band: 18p11.22 HGNC cytogenetic band: 18p11.22RAB12 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 18 GeneLoc Exon Structure GeneLoc location for GC18P008600: view genomic region
(about GC identifiers)
Start:
|
8,609,443 bp from pter |
End:
|
8,639,380 bp from pter |
Size:
|
29,938 bases |
Orientation:
|
plus strand |
|
Proteins
for RAB12 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RAB12_HUMAN, Q6IQ22 (See
protein sequence)Recommended Name: Ras-related protein Rab-12 Size: 244 amino acids; 27248 Da
Subunit: May interact with RABIF
Subcellular location: Recycling endosome membrane; Lipid-anchor; Cytoplasmic side (By similarity). Lysosome membrane;Lipid-anchor; Cytoplasmic side (By similarity). Golgi apparatus membrane (By similarity)
Sequence caution: Sequence=AAH71600.2; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=AAH98407.1;Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=BC050338; Type=Frameshift; Positions=195;
1 PDB 3D structure from  and Proteopedia  for RAB12:2IL1 (3D)
Secondary accessions: A6NEF5 Q4KMQ3Explore the universe of human proteins at neXtProt for RAB12: NX_Q6IQ22
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6IQ22
RAB12 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001020471.2
ENSEMBL proteins: ENSP00000331748
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
RAB12 for ontologies About GeneDecksing
RAB12 Antibody Products:
Assay Products for RAB12: |
Protein
Domains /
Families
for RAB12 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RAB12 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6IQ22ProtoNet protein and cluster: Q6IQ22 UniProtKB/Swiss-Prot: RAB12_HUMAN, Q6IQ22Similarity: Belongs to the small GTPase superfamily. Rab family |
Function
for RAB12 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RAB12_HUMAN, Q6IQ22Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation oftransport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an activeGTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible forvesicle formation, movement, tethering and fusion. That Rab may play a role in protein transport from recyclingendosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor (By similarity)Enzyme regulation: Rab activation is generally mediated by a guanine exchange factor (GEF), while inactivation throughhydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP) (By similarity). That Rab is activated byDENND3, a guanine exchange factor
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAB12 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAB12
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RAB12 (NM_001025300) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RAB12 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat RAB12 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB12 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
RAB12 for ontologies About GeneDecksing
|
Pathways & Interactions
for RAB12 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RAB12
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
5 Interacting proteins for RAB12 (Q6IQ223 ENSP000003317484) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007264 | small GTPase mediated signal transduction |
IEA | -- | | GO:0008333 | endosome to lysosome transport |
ISS | -- | | GO:0015031 | protein transport |
IEA | -- | | GO:0044257 | cellular protein catabolic process |
ISS | -- |
RAB12 for ontologies About GeneDecksing
|
Drugs & Compounds
for RAB12 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RAB12
Search CenterWatch for drugs/clinical trials and news about RAB12
|
Transcripts
for RAB12 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RAB12 gene: NM_001025300.2 Unigene Cluster for RAB12: RAB12, member RAS oncogene family Hs.270074 [show with all ESTs]Unigene Representative Sequence: BC0716002 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000329286(uc002knp.3) ENST00000580987
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAB12 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAB12
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RAB12 (NM_001025300) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RAB12 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat RAB12 |
Additional cDNA sequence: AK127824.1 BC050338.1 BC071600.1 BC098407.1 CR627121.1 5 DOTS entries: DT.97793083 DT.101971256 DT.108281 DT.407758 DT.411259 24/53 AceView cDNA sequences (see all 53): BX642232 BQ024519 BC050338 CD518316 AI080373 AI356332 BU754385 AA001052 BX493064 BC071600 AW449532 CR627121 AA680106 CF994415 AA824235 R02835 AW452366 BF574430 AI076335 AW449830 AI032693 AA587104 AA001088 AA027097
GeneLoc Exon Structure
|
Expression
for RAB12 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RAB12 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTTCCTAAG
About this image
See RAB12 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RAB12
SOURCE GeneReport for Unigene cluster: Hs.270074
SABiosciences Custom PCR Arrays for RAB12
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAB12
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat RAB12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAB12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAB12 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB12 |
Orthologs
for RAB12 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RAB12 gene from 5/12 species (see all 12) About this table
ENSEMBL Gene Tree for RAB12 (if available)
TreeFam Gene Tree for RAB12 (if available) |
Paralogs
for RAB12 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RAB12 gene
- RAB102 RAB192 RAB432 RAB182 RAB262 RAB8A2 RAB372 RAB352
- RAB8B2 RAB1B2 RAB302 RAB1A2 RAB132
18/96 SIMAP similar genes for RAB12 using alignment to 1 protein entry: RAB12_HUMAN(see all similar genes):DKFZp686J06205 rab1b RAB10 RAB8B RAB8A RAB30
RAB13 RAB19 RAB1C RAB3B RAB15 RAB39B
RAB6A' RAB41 RAB43 DKFZp686J07132 RAB3A RAB3C
RAB12 for paralogs About GeneDecksing
|
Genomic Variants
for RAB12 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 18 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RAB12 (8609443 - 8639380 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RAB12
1 Indel: 41710 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAB12 |
|
Disorders
/ Diseases
for RAB12 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RAB12 for disorders About GeneDecksing
1  disease for RAB12: About MalaCardspustulosis of palm and sole
1 disease from the University of Copenhagen DISEASES database for RAB12:Pustulosis of palm and sole Export disorders for RAB12 gene to outside databases
|
Publications
for RAB12 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RAB12 gene integrated from 9 sources:
(articles sorted by number of sources associating them with RAB12) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Identification and characterisation of novel Mss4-binding Rab GTPases. (PubMed id 21194374)2 Wixler V.... Itzen A. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Integrative analysis of the ubiquitin proteome isolat ed using Tandem Ubiquitin Binding Entities (TUBEs). (PubMed id 22178446)1 Lopitz-Otsoa F....Rodriguez M.S. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors. (PubMed id 20937701)2 Yoshimura S.... Barr F.A. (2010)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- DNA sequence and analysis of human chromosome 18. (PubMed id 16177791)2 Nusbaum C.... Lander E.S. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for RAB12 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RAB12 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RAB12 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RAB12 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for RAB12 gene:
Search GeneIP for patents involving RAB12
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RAB12 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RAB12 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAB12 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAB12 | | | OriGene Protein Over-expression Lysate for RAB12 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RAB12 | | OriGene 3'-UTR Clone for RAB12 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAB12 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAB12 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for RAB12 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RAB12 | | OriGene Custom Protein Services for RAB12 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RAB12 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAB12 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB12 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAB12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAB12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAB12 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for RAB12 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | RAB12 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB12 |
|  |  |  | | | | Search ThermoFisher Antibodies for RAB12 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat RAB12 |
|
|
|
|
