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Aliases for RAB11FIP5 Gene

Aliases for RAB11FIP5 Gene

  • RAB11 Family Interacting Protein 5 (Class I) 2 3
  • RIP11 3 4 6
  • Rab11-Interacting Protein Rip11 3 4
  • Gamma-SNAP-Associated Factor 1 3 4
  • Phosphoprotein Pp75 3 4
  • Rab11-FIP5 3 4
  • KIAA0857 4 6
  • Gaf-1 3 4
  • GAF1 3 4
  • Rab11 Family-Interacting Protein 5 3
  • RAB11RIP5 6
  • Pp75 3

External Ids for RAB11FIP5 Gene

Previous GeneCards Identifiers for RAB11FIP5 Gene

  • GC02M073212

Summaries for RAB11FIP5 Gene

GeneCards Summary for RAB11FIP5 Gene

RAB11FIP5 (RAB11 Family Interacting Protein 5 (Class I)) is a Protein Coding gene. Diseases associated with RAB11FIP5 include atypical autism. Among its related pathways are Endocytosis and Delta508-CFTR traffic / ER-to-Golgi in CF. GO annotations related to this gene include gamma-tubulin binding. An important paralog of this gene is RAB11FIP1.

UniProtKB/Swiss-Prot for RAB11FIP5 Gene

  • Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis.

Gene Wiki entry for RAB11FIP5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB11FIP5 Gene

Genomics for RAB11FIP5 Gene

Regulatory Elements for RAB11FIP5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RAB11FIP5 Gene

73,073,382 bp from pter
73,156,721 bp from pter
83,340 bases
Minus strand

Genomic View for RAB11FIP5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAB11FIP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB11FIP5 Gene

Proteins for RAB11FIP5 Gene

  • Protein details for RAB11FIP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rab11 family-interacting protein 5
    Protein Accession:
    Secondary Accessions:
    • O94939
    • Q9P0M1

    Protein attributes for RAB11FIP5 Gene

    653 amino acids
    Molecular mass:
    70415 Da
    Quaternary structure:
    • Forms a heterooligomeric complex with RAB11FIP4. Binds NAPG and TROVE2. Binds RAB11A that has been activated by GTP binding.
    • Antibodies against RIP11 are found in sera from patients with autoimmune diseases such as systemic lupus erythematosus (SLE) or Sjoegren syndrome (SS). It is also found in the sera from mothers of children with neonatal lupus erythematosus (NLE)
    • Sequence=BAA74880.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for RAB11FIP5 Gene

Proteomics data for RAB11FIP5 Gene at MOPED

Post-translational modifications for RAB11FIP5 Gene

  • Phosphorylated on serine and threonine residues. Phosphorylation at Ser-357 is PKA-dependent.
  • Ubiquitination at Lys586
  • Modification sites at PhosphoSitePlus

Other Protein References for RAB11FIP5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RAB11FIP5 Gene

Domains for RAB11FIP5 Gene

Protein Domains for RAB11FIP5 Gene


Suggested Antigen Peptide Sequences for RAB11FIP5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9BXF6
  • Binds to vesicles enriched in neutral phospholipids via its C2 domain. The interaction is favored by Mg(2+) rather than Ca(2+)
  • Contains 1 C2 domain.
  • Contains 1 FIP-RBD domain.
genes like me logo Genes that share domains with RAB11FIP5: view

No data available for Gene Families for RAB11FIP5 Gene

Function for RAB11FIP5 Gene

Molecular function for RAB11FIP5 Gene

UniProtKB/Swiss-Prot Function: Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis.

Gene Ontology (GO) - Molecular Function for RAB11FIP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11278501
GO:0017137 Rab GTPase binding IBA --
GO:0043015 gamma-tubulin binding IDA 11278501
genes like me logo Genes that share ontologies with RAB11FIP5: view

Phenotypes for RAB11FIP5 Gene

GenomeRNAi human phenotypes for RAB11FIP5:
genes like me logo Genes that share phenotypes with RAB11FIP5: view

Animal Model Products

CRISPR Products

miRNA for RAB11FIP5 Gene

miRTarBase miRNAs that target RAB11FIP5

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAB11FIP5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RAB11FIP5 Gene

Localization for RAB11FIP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB11FIP5 Gene

Cytoplasm. Recycling endosome membrane; Peripheral membrane protein. Early endosome membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Mitochondrion membrane; Peripheral membrane protein.

Subcellular locations from

Jensen Localization Image for RAB11FIP5 Gene COMPARTMENTS Subcellular localization image for RAB11FIP5 gene
Compartment Confidence
endosome 5
mitochondrion 5
cytoskeleton 4
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for RAB11FIP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005739 mitochondrion --
GO:0005741 mitochondrial outer membrane IDA 11278501
GO:0005769 early endosome ISS --
GO:0005794 Golgi apparatus ISS --
genes like me logo Genes that share ontologies with RAB11FIP5: view

Pathways for RAB11FIP5 Gene

genes like me logo Genes that share pathways with RAB11FIP5: view

Pathways by source for RAB11FIP5 Gene

1 KEGG pathway for RAB11FIP5 Gene
1 GeneGo (Thomson Reuters) pathway for RAB11FIP5 Gene

Gene Ontology (GO) - Biological Process for RAB11FIP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport --
GO:0035773 insulin secretion involved in cellular response to glucose stimulus ISS --
GO:0045055 regulated secretory pathway ISS --
GO:0070164 negative regulation of adiponectin secretion IDA 24040321
GO:0071468 cellular response to acidic pH IDA 20717956
genes like me logo Genes that share ontologies with RAB11FIP5: view

Compounds for RAB11FIP5 Gene

(1) HMDB Compounds for RAB11FIP5 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
genes like me logo Genes that share compounds with RAB11FIP5: view

Transcripts for RAB11FIP5 Gene

Unigene Clusters for RAB11FIP5 Gene

RAB11 family interacting protein 5 (class I):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAB11FIP5

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for RAB11FIP5
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB11FIP5 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b
SP1: - - - -
SP2: - - -
SP3: - - - - - -
SP4: - -
SP6: -

Relevant External Links for RAB11FIP5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RAB11FIP5 Gene

mRNA expression in normal human tissues for RAB11FIP5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB11FIP5 Gene

This gene is overexpressed in Testis (5.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB11FIP5 Gene

SOURCE GeneReport for Unigene cluster for RAB11FIP5 Gene Hs.24557

mRNA Expression by UniProt/SwissProt for RAB11FIP5 Gene

Tissue specificity: Detected at low levels in heart, brain, placenta, lung, liver, adipocytes, kidney, spleen, skeletal muscle and pancreas.
genes like me logo Genes that share expressions with RAB11FIP5: view

In Situ Assay Products

Orthologs for RAB11FIP5 Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB11FIP5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RAB11FIP5 35
  • 99.23 (n)
  • 99.39 (a)
RAB11FIP5 36
  • 99 (a)
(Bos Taurus)
Mammalia RAB11FIP5 35
  • 88.82 (n)
  • 90.2 (a)
RAB11FIP5 36
  • 44 (a)
(Canis familiaris)
Mammalia RAB11FIP5 35
  • 89.51 (n)
  • 89.91 (a)
RAB11FIP5 36
  • 43 (a)
(Mus musculus)
Mammalia Rab11fip5 35
  • 84.38 (n)
  • 85.74 (a)
Rab11fip5 16
Rab11fip5 36
  • 87 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 34 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 23 (a)
(Rattus norvegicus)
Mammalia Rab11fip5 35
  • 82.88 (n)
  • 84.45 (a)
(Gallus gallus)
Aves RAB11FIP5 36
  • 26 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18355 35
(Danio rerio)
Actinopterygii RAB11FIP5 (1 of 2) 36
  • 17 (a)
rab11fip5a 36
  • 34 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rip11 36
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8553 36
  • 20 (a)
Species with no ortholog for RAB11FIP5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAB11FIP5 Gene

Gene Tree for RAB11FIP5 (if available)
Gene Tree for RAB11FIP5 (if available)

Paralogs for RAB11FIP5 Gene

Paralogs for RAB11FIP5 Gene

Selected SIMAP similar genes for RAB11FIP5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RAB11FIP5: view

Variants for RAB11FIP5 Gene

Sequence variations from dbSNP and Humsavar for RAB11FIP5 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs727469 -- 73,094,846(-) CTTTG(A/G)TAACT intron-variant
rs727470 -- 73,094,843(-) TGGTA(A/G)CTTAC intron-variant
rs727471 -- 73,094,765(-) TGGGA(A/G)GGCAA intron-variant
rs891431 -- 73,093,370(+) TCTGG(C/G)AGCAC intron-variant
rs891432 -- 73,093,489(+) CCAAA(C/G)TAAAG intron-variant

Relevant External Links for RAB11FIP5 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RAB11FIP5 Gene

Disorders for RAB11FIP5 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for RAB11FIP5 Gene including...

Search for RAB11FIP5 Gene in MalaCards »

(1) University of Copenhagen DISEASES for RAB11FIP5 Gene

Relevant External Links for RAB11FIP5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with RAB11FIP5: view

No data available for UniProtKB/Swiss-Prot for RAB11FIP5 Gene

Publications for RAB11FIP5 Gene

  1. Defining a novel 75-kDa phosphoprotein associated with SS-A/Ro and identification of distinct human autoantibodies. (PMID: 10545525) Wang D. … Chan E.K.L. (J. Clin. Invest. 1999) 3 4 23
  2. Gaf-1, a gamma-SNAP-binding protein associated with the mitochondria. (PMID: 11278501) Chen D. … Whiteheart S.W. (J. Biol. Chem. 2001) 3 4 23
  3. Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and its overexpression condenses the Rab11 positive compartment in HeLa cells. (PMID: 12470645) Wallace D.M. … McCaffrey M.W. (Biochem. Biophys. Res. Commun. 2002) 3 4 23
  4. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  5. A Rab11/Rip11 protein complex regulates apical membrane trafficking via recycling endosomes. (PMID: 11163216) Prekeris R. … Scheller R.H. (Mol. Cell 2000) 2 3 4

Products for RAB11FIP5 Gene

Sources for RAB11FIP5 Gene

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