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Aliases & Descriptions for RAB11FIP5
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| DKFZp434H018 2 | | GAF1 1, 2, 3 | | Gaf-1 3 | | KIAA0857 1, 2, 3 | | RIP11 1, 2, 3 | | Rab11-FIP5 3 | | pp75 1, 2 |
| | | Descriptions |
|---|
| Gamma-SNAP-associated factor 1 2, 3 | | Phosphoprotein pp75 3 | | RAB11 family interacting protein 5 (class I) 2 | | Rab11-interacting protein 2 | | Rab11-interacting protein Rip11 3 |
|
| | Search outside databases for aliases for RAB11FIP5 gene |
Summaries for RAB11FIP5(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: RFIP5_HUMAN, Q9BXF6Function: Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membraneGene Wiki entry for RAB11FIP5 |
Genomic Location for RAB11FIP5
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the RAB11FIP5 gene 
Entrez Gene cytogenetic band: 2p13-p12 Ensembl cytogenetic band: 2p13.2 HGNC cytogenetic band: 2p13RAB11FIP5 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M073212:
(about GC identifiers)
Start:
|
73,154,018 bp from pter |
End:
|
73,193,654 bp from pter |
Size:
|
39,637 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000002.10 NT_022184.14
| Proteins for RAB11FIP5
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: RFIP5_HUMAN, Q9BXF6 (See
protein sequence)Recommended Name: Rab11 family-interacting protein 5 Size: 653 amino acids; 70415 Da
Subunit: Forms an heterooligomeric complex with RAB11FIP4. Binds NAPG and SSA2. Binds RAB11A that has been activated by GTP binding
Subcellular location: Cytoplasm. Recycling endosome membrane; Peripheral membrane protein. Mitochondrion membrane; Peripheral membrane protein
Secondary accessions: O94939 Q9P0M1Post-translational modifications:
Phosphorylated on serine and threonine residues1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_056285.1
ENSEMBL proteins: ENSP00000258098 ENSP00000374159
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6
): About this table
Antibodies for RAB11FIP5: Assays for RAB11FIP5: | Protein
Domains/ Families for RAB11FIP5(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9BXF6
ProtoNet protein and cluster: Q9BXF6 1 Blocks protein family: IPB000008 C2 domain
UniProtKB/Swiss-Prot: RFIP5_HUMAN, Q9BXF6Domain: Binds to vesicles enriched in neutral phospholipids via its C2 domain. The interaction is favored by Mg(2+) rather than Ca(2+)Similarity: Contains 1 C2 domain | Gene Function for RAB11FIP5
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_015470
Applied Biosystems Silencer® siRNAs for RAB11FIP5
Sigma-Aldrich siRNA for RAB11FIP5  Sigma-Aldrich shRNA for RAB11FIP5  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_015470                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_015470                                  untagged cDNA clones in CMV expression vector (see all 2): AL117579 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_015470
UniProtKB/Swiss-Prot: RFIP5_HUMAN, Q9BXF6Function: Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane2 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for RAB11FIP5
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for RAB11FIP5 
5/12 Interacting proteins for RAB11FIP5 (ENSP000003741593) via UniProtKB, MINT, and/or STRING (see all 12
)About this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- | | GO:0015031 | protein transport |
IEA | -- | About this table
|
Drugs & Compounds for RAB11FIP5(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for RAB11FIP5
|
Transcripts for RAB11FIP5(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_015470
Sigma-Aldrich siRNA for RAB11FIP5  Sigma-Aldrich shRNA for RAB11FIP5  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_015470 REFSEQ mRNAs for RAB11FIP5 gene: NM_015470.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_015470               OriGene GFP tagged cDNA clone in CMV expression vector: NM_015470                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_015470                                  untagged cDNA clones in CMV expression vector (see all 2): AL117579  Additional cDNA sequence: AB020664.1 AF153085.1 AF334812.1 AK023823.1 AK024727.1 AL117579.1 BC035013.1 BC099902.1 CR590374.1 6 DOTS entries: DT.95193266 DT.100786167 DT.100786169 DT.120982464 DT.120982480 DT.80100253 24/367 AceView cDNA sequences (see all 367
):AI671805 BU541928 BF530403 AI968321 AU140662 CB049377 BI252970 AW590297 BU856838 Z45690 BM985431 CB243462 R32793 CB140288 AI140990 BQ671150 BE549871 BX280798 CA313291 BC046630 AI358847 BQ219103 CA416568 BM850044
highest scoring ESTs for RAB11FIP5:AB020664 AF153085 AF334812 AL121414 BC035013 BF589002 BI462412 BI553332 BU849057 AA043920 Unigene Cluster for RAB11FIP5: RAB11 family interacting protein 5 (class I) Hs.24557 [show with all ESTs]Unigene Representative Sequence: NM_015470
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for RAB11FIP5 (see all 6
)
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | |
| SP1: | |   | - |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | - |   | - |   | - |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for RAB11FIP5
2 Ensembl transcripts including schematic representations: ENST00000258098
ENST00000389508
|
Expression for RAB11FIP5
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| RAB11FIP5 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for RAB11FIP5
1 / 2 / 3 3 probe-sets matching RAB11FIP5 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.24557 UniProtKB/Swiss-Prot: RFIP5_HUMAN, Q9BXF6Tissue specificity: Detected at low levels in heart, brain, placenta, lung, liver, adipocytes, kidney, spleen, skeletal muscle and pancreas |
Orthologs for RAB11FIP5
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for RAB11FIP5 gene from 5/6 species (see all 6
)
About this table Species with no ortholog for RAB11FIP5
ENSEMBL Gene Tree for RAB11FIP5 | Paralogs for RAB11FIP5(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for RAB11FIP5 gene
- RAB11FIP12 RAB11FIP22
|
SNPs/Variants for RAB11FIP5(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for RAB11FIP5 (up to first 250kb)
|
Disorders & Mutations for RAB11FIP5
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 605536
UniProtKB/Swiss-Prot: RFIP5_HUMAN, Q9BXF6
Antibodies against RIP11 are found in sera from patients with systemic lupus erythematosus (SLE) or Sjoegren syndrome (SS), and in the sera from mothers of children with neonatal lupus erythematosus (NLE)Human Gene Mutation Database: RAB11FIP5
|
Medical News for RAB11FIP5(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for RAB11FIP5 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/27 PubMed articles for RAB11FIP5 gene (see all 27
):- A Rab11/Rip11 protein complex regulates apical membrane trafficking via recycling endosomes. (PubMed id 11163216)2, 3, 4 Prekeris R....Scheller R.H. (2000)
- Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)2, 3, 4 Nagase T....Ohara O. (1998)
- Gaf-1, a gamma-SNAP-binding protein associated with the mitochondria. (PubMed id 11278501)1, 3, 4 Chen D.... Whiteheart S.W. (2001)
- Defining a novel 75-kDa phosphoprotein associated with SS-A/Ro and identification of distinct human autoantibodies. (PubMed id 10545525)1, 3, 4 Wang D.... Chan E.K.L. (1999)
- Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and its overexpression condenses the Rab11 positive compartment in HeLa cells. (PubMed id 12470645)1, 3, 4 Wallace D.M.... McCaffrey M.W. (2002)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)3, 4 Olsen J.V....Mann M. (2006)
- Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)3, 4 Brill L.M....Peters E.C. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- A de novo apparently balanced translocation [46,XY,t(2;9)(p13;p24)] interrupting RAB11FIP5 identifies a potential candidate gene for autism spectrum disorder. (PubMed id 18384058)1, 3 Roohi J....Hatchwell E. (2008)
- Mapping of functional domains of gamma-SNAP. (PubMed id 12554740)1, 3 Tani K....Tagaya M. (2003)
|
Search for RAB11FIP5
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing RAB11FIP5
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing RAB11FIP5
(According to HUGE)
About This Section
| |
Specialized Databases showing RAB11FIP5(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for RAB11FIP5(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for RAB11FIP5:

|
GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
|