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RAB11FIP5 Gene

protein-coding   GIFtS: 54

GC02M073212
RAB11 family interacting protein 5 (class I)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
DKFZp434H018 2
GAF1 1, 2, 3
Gaf-1 3
KIAA0857 1, 2, 3
RIP11 1, 2, 3
Rab11-FIP5 3
pp75 1, 2
Descriptions
Gamma-SNAP-associated factor 1 2, 3
Phosphoprotein pp75 3
RAB11 family interacting protein 5 (class I) 2
Rab11-interacting protein 2
Rab11-interacting protein Rip11 3
External Ids
HGNC: 248451
Entrez Gene: 260562
UniProtKB: Q9BXF63
Ensembl: ENSG000001356317
Search outside databases for aliases for RAB11FIP5 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: RFIP5_HUMAN, Q9BXF6
Function: Rab effector involved in protein trafficking from apical recycling endosomes to the
apical plasma membrane

Gene Wiki entry for RAB11FIP5

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the RAB11FIP5 gene  

Entrez Gene cytogenetic band: 2p13-p12   Ensembl cytogenetic band:  2p13.2   HGNC cytogenetic band: 2p13

RAB11FIP5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M073212:     (about GC identifiers)

Start:
73,154,018 bp from pter
End:
73,193,654 bp from pter
Size:
39,637 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000002.10  NT_022184.14  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: RFIP5_HUMAN, Q9BXF6 (See protein sequence)
Recommended Name: Rab11 family-interacting protein 5  
Size: 653 amino acids; 70415 Da
Subunit: Forms an heterooligomeric complex with RAB11FIP4. Binds NAPG and SSA2. Binds RAB11A that
has been activated by GTP binding
Subcellular location: Cytoplasm. Recycling endosome membrane; Peripheral membrane protein.
Mitochondrion membrane; Peripheral membrane protein
Secondary accessions: O94939 Q9P0M1

Post-translational modifications:

  • Phosphorylated on serine and threonine residues1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_056285.1  

    ENSEMBL proteins: 
    ENSP00000258098 ENSP00000374159 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (RAB11FIP5)
    Human Recombinant Proteins from Abnova (RAB11FIP5)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737 cytoplasm IEA--
    GO:0005739 mitochondrion IEA--
    GO:0005741 mitochondrial outer membrane IDA11278501
    GO:0005768 endosome IEA--
    GO:0016020 membrane IEA--
    About this table

    Antibodies for RAB11FIP5: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (RAB11FIP5), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (RAB11FIP5)
    Novus Biologicals Antibodies for RAB11FIP5

    Assays for RAB11FIP5: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    3 InterPro domains/families:
     IPR018029 C2_membr_targeting
     IPR019018 Rab11-bd_FIP_dom_C
     IPR000008 C2_Ca-dep


       GeneDecks  RAB11FIP5 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q9BXF6

    ProtoNet protein and cluster: Q9BXF6

    1 Blocks protein family: IPB000008 C2 domain

    UniProtKB/Swiss-Prot: RFIP5_HUMAN, Q9BXF6
    Domain: Binds to vesicles enriched in neutral phospholipids via its C2 domain. The interaction is
    favored by Mg(2+) rather than Ca(2+)
    Similarity: Contains 1 C2 domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (RAB11FIP5)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_015470

                  Applied Biosystems Silencer® siRNAs for RAB11FIP5

                  Sigma-Aldrich siRNA for RAB11FIP5  
                         Sigma-Aldrich shRNA for RAB11FIP5  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for RAB11FIP5
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_015470
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_015470
                                     untagged cDNA clones in CMV expression vector (see all 2): AL117579 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_015470

    UniProtKB/Swiss-Prot: RFIP5_HUMAN, Q9BXF6
    Function: Rab effector involved in protein trafficking from apical recycling endosomes to the
    apical plasma membrane

    2 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515 protein binding IPI11278501
    GO:0043015 gamma-tubulin binding IDA11278501
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


     Gene Network CentralTM Interacting Genes and Proteins Network for  RAB11FIP5 


    5/12 Interacting proteins for RAB11FIP5 (ENSP000003741593) via UniProtKB, MINT, and/or STRING (see all 12 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAB11AENSP000002618903STRING (score=.994)
    PCK2ENSP000002167803STRING (score=.947)
    RAB11FIP4ENSP000003128373STRING (score=.947)
    PCK1ENSP000003198143STRING (score=.943)
    MYO5BENSP000002850393STRING (score=.874)
    About this table

    2 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150 biological_process ND--
    GO:0015031 protein transport IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for RAB11FIP5

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (RAB11FIP5)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_015470

                  Sigma-Aldrich siRNA for RAB11FIP5  
                         Sigma-Aldrich shRNA for RAB11FIP5  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_015470  

    REFSEQ mRNAs for RAB11FIP5 gene: 

    NM_015470.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_015470  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_015470
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_015470
                                     untagged cDNA clones in CMV expression vector (see all 2): AL117579 

    Additional cDNA sequence: 

    AB020664.1 AF153085.1 AF334812.1 AK023823.1 AK024727.1 AL117579.1 BC035013.1 BC099902.1 
    CR590374.1 

    6 DOTS entries:

    DT.95193266  DT.100786167  DT.100786169  DT.120982464  DT.120982480  DT.80100253 

    24/367 AceView cDNA sequences (see all 367 ):

    AI671805 BU541928 BF530403 AI968321 AU140662 CB049377 BI252970 AW590297 
    BU856838 Z45690 BM985431 CB243462 R32793 CB140288 AI140990 BQ671150 
    BE549871 BX280798 CA313291 BC046630 AI358847 BQ219103 CA416568 BM850044 

    highest scoring ESTs for RAB11FIP5:

    AB020664 AF153085 AF334812 AL121414 BC035013 BF589002 BI462412 BI553332 BU849057 AA043920 

    Unigene Cluster for RAB11FIP5:

    RAB11 family interacting protein 5 (class I)
    Hs.24557  [show with all ESTs]
    Unigene Representative Sequence: NM_015470


    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for RAB11FIP5 (see all 6 )

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b
    SP1:        -                                   -     -     -                           
    SP2:                                            -     -     -                           
    SP3:                    -     -     -           -     -     -                           
    SP4:                                                  -     -                           
    SP5:                                                                                    

    About this scheme

    ECgene alternative splicing isoforms for RAB11FIP5

    2 Ensembl transcripts including schematic representations:
    ENST00000258098  ENST00000389508  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    RAB11FIP5 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for RAB11FIP5

    1 / 2 / 3

    3 probe-sets matching RAB11FIP5 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    33882_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 AB020664 1.00 1.00 1.00 1

    210879_s_at2, 3 U133-A 1 1.00 1.00 -- -- AF334812 0.80 1.00 0.91 1

    210879_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  RAB11FIP5 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.24557

    UniProtKB/Swiss-Prot: RFIP5_HUMAN, Q9BXF6
    Tissue specificity: Detected at low levels in heart, brain, placenta, lung, liver, adipocytes,
    kidney, spleen, skeletal muscle and pancreas

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for RAB11FIP5 gene from 5/6 species (see all 6 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    RAB11FIP51   -- RAB11 family interacting protein 5 (class I) 89.93(n)
    90.82(a)
    483115  XM_540231.2  XP_540231.2 
    cow
    (Bos taurus)
    RAB11FIP51   -- RAB11 family interacting protein 5 (class I) 88.82(n)
    90.2(a)
    535992  XM_616110.3  XP_616110.3 
    mouse
    (Mus musculus)
    Rab11fip51, 5 6 (35.50 cM)5
    RAB11 family interacting protein 5 (class I)1, 5 84.95(n)1
    86.48(a)1
    520551  NM_001003955.21  NP_001003955.11 
     AI8438845  AK0789385  (see all 19)
    chicken
    (Gallus gallus)
    RAB11FIP51   -- RAB11 family interacting protein 5 (class I) 66.74(n)
    62.37(a)
    422952  XM_420890.2  XP_420890.2 
    zebrafish
    (Danio rerio)
    LOC5709391   -- similar to Rab11 family-interacting protein 5 (Rab11-FIP5) more 57.28(n)
    48.95(a)
    570939  XM_694475.3  XP_699567.3 
    About this table        Species with no ortholog for RAB11FIP5

    ENSEMBL Gene Tree for RAB11FIP5
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for RAB11FIP5 gene
    RAB11FIP12  RAB11FIP22  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/172 NCBI SNPs in RAB11FIP5 are shown (see all 172 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 50)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 2 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs10461831,2
    C,F,H,O73155325(-) TGTCTA/GTTCTT 1 -- ut315Minor allele frequency- G:0.17MN EU EA WA 602
    rs19921331,2
    A,C,F,H73155126(-) ACAGCA/GCTGCT 1 -- ut31 ese36Minor allele frequency- G:0.46EA EU WA 590
    rs10461861,2
    A,C73155195(-) TGTGGC/TGTCCC 1 -- ut31 ese30--------
    rs170086541,2
    F73155110(+) GAGGGG/TAACAG 1 -- ut31 trp31Minor allele frequency- T:0.08MN 184
    rs18644881,2
    A,C,F73193216(-) GGCTGC/TCCCGA 1 C/C syn13Minor allele frequency- T:0.45EA 1678
    rs14303491,2
    A,C,F,H,O73187493(-) AGTGGA/GGAAGG 1 -- int1 trp310Minor allele frequency- G:0.36NA EA MN EU WA 1096
    rs65468001,2
    A,C,F,H73167471(+) AGGCAA/GGGGGT 1 -- int14Minor allele frequency- G:0.48EU EA WA 418
    rs67279191,2
    A,C,F,H73172620(+) GCTAAT/GTGAGA 1 -- int14Minor allele frequency- G:0.46EU EA WA 408
    rs39012731,2
    A,C,F,H73170048(+) CTCTGA/TGAGCC 1 -- int112Minor allele frequency- T:0.41MN EU EA WA NA 1146
    rs67092691,2
    A,C,F,H73163100(+) TTCTAT/CTGATC 1 -- int18Minor allele frequency- C:0.08EU EA WA 820
    About this table

    HapMap Linkage Disequilibrium images for RAB11FIP5 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 605536

    UniProtKB/Swiss-Prot: RFIP5_HUMAN, Q9BXF6
  • Antibodies against RIP11 are found in sera from patients with systemic lupus erythematosus
    (SLE) or Sjoegren syndrome (SS), and in the sera from mothers of children with neonatal lupus
    erythematosus (NLE)
  • Human Gene Mutation Database: RAB11FIP5

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/27 PubMed articles for RAB11FIP5 gene (see all 27 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 26056 HGNC: 24845 AceView: RAB11FIP5andSFXN5 Ensembl:ENSG00000135631 euGenes: HUgn26056
    ECgene: RAB11FIP5 H-InvDB: RAB11FIP5
    (According to HUGE)
    About This Section

    HUGE: KIAA0857
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for RAB11FIP5:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Predesigned and custom siRNAs for RAB11FIP5 Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
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