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RAB11FIP4 Gene

protein-coding   GIFtS: 50

GC17P026742
RAB11 family interacting protein 4 (class II)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
FLJ00131 1, 2
KIAA1821 1, 2, 3, 5
MGC11316 1, 2
MGC126566 2
RAB11-FIP4 1, 2
Rab11-FIP4 3
Descriptions
RAB11 family interacting protein 4 (class II) 2
External Ids
HGNC: 302671
Entrez Gene: 844402
UniProtKB: Q86YS33
Ensembl: ENSG000001312427
Search outside databases for aliases for RAB11FIP4 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for RAB11FIP4:
Proteins of the large Rab GTPase family (see RAB1A; MIM 179508) have regulatory roles in the
formation, targeting, and fusion of intracellular transport vesicles. RAB11FIP4 is one of many
proteins that interact with and regulate Rab GTPases (Hales et al., 2001 [PubMed
11495908]).[supplied by OMIM]

UniProtKB/Swiss-Prot: RFIP4_HUMAN, Q86YS3
Function: A Rab11 effector protein acting in the endosomal trafficking

Gene Wiki entry for RAB11FIP4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the RAB11FIP4 gene  

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q11.2   HGNC cytogenetic band: 17q11.2

RAB11FIP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P026742:     (about GC identifiers)

Start:
26,742,768 bp from pter
End:
26,889,356 bp from pter
Size:
146,589 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000017.9  NT_010799.14  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: RFIP4_HUMAN, Q86YS3 (See protein sequence)
Recommended Name: Rab11 family-interacting protein 4  
Size: 637 amino acids; 71928 Da
Subunit: Homooligomer. Forms an heterooligomeric complex with RAB11FIP2, RAB11FIP3 and RAB11FIP5.
Interacts with RAB11A that has been activated by GTP binding
Subcellular location: Recycling endosome membrane; Peripheral membrane protein. Note=Colocalizes
with RAB11A in the endocytic recycling compartment (ERC)
Secondary accessions: Q52LI1 Q8N829 Q8NDT7 Q969D8
Alternative splicing: 2 isoforms:  Q86YS3-1   Q86YS3-2   

REFSEQ proteins: NP_116321.2  

ENSEMBL proteins: 
ENSP00000378225 ENSP00000378227 ENSP00000312837 


Human Recombinant Proteins 
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Browse Purified and Recombinant Proteins at Millipore
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Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (RAB11FIP4)
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005768 endosome IEA--
GO:0016020 membrane IEA--
GO:0055038 recycling endosome membrane IEA--
About this table

Antibodies for RAB11FIP4: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Antibodies from Abcam (RAB11FIP4), each with their AbpromiseSM
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for RAB11FIP4

Assays for RAB11FIP4: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

4 InterPro domains/families:
 IPR011992 EF-Hand_type
 IPR018249 EF_HAND_2
 IPR018247 EF_HAND_1
 IPR019018 Rab11-bd_FIP_dom_C


   GeneDecks  RAB11FIP4 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q86YS3

ProtoNet protein and cluster: Q86YS3

UniProtKB/Swiss-Prot: RFIP4_HUMAN, Q86YS3
Similarity: Contains 1 EF-hand domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (RAB11FIP4)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_032932

              Applied Biosystems Silencer® siRNAs for RAB11FIP4

              Sigma-Aldrich siRNA for RAB11FIP4  
                     Sigma-Aldrich shRNA for RAB11FIP4  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_032932
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_032932
                                 untagged cDNA clones in CMV expression vector (see all 4): BC006240 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_032932

UniProtKB/Swiss-Prot: RFIP4_HUMAN, Q86YS3
Function: A Rab11 effector protein acting in the endosomal trafficking

1 Gene Ontology (GO) molecular function term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005509 calcium ion binding IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/10 Interacting proteins for RAB11FIP4 (ENSP000003128373) via UniProtKB, MINT, and/or STRING (see all 10 )
InteractantInteraction Details
GeneCardExternal ID(s)
RAB11FIP2ENSP000003582003STRING (score=.972)
RAB11FIP5ENSP000003741593STRING (score=.947)
RAB11FIP1ENSP000003313423STRING (score=.935)
RAB11AENSP000002618903STRING (score=.889)
UNC119ENSP000003370403STRING (score=.865)
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1 Gene Ontology (GO) biological process term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0015031 protein transport IEA--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for RAB11FIP4

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (RAB11FIP4)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_032932

              Sigma-Aldrich siRNA for RAB11FIP4  
                     Sigma-Aldrich shRNA for RAB11FIP4  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_032932  

REFSEQ mRNAs for RAB11FIP4 gene: 

NM_032932.3   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_032932  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_032932
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_032932
                                 untagged cDNA clones in CMV expression vector (see all 4): BC006240 

Additional cDNA sequence: 

AB058724.1 AJ314646.2 AK055019.1 AK074060.1 AK074341.1 AK097424.1 AL359563.2 AL831830.1 
AY169244.1 BC004515.2 BC006240.2 BC023618.2 BC047674.2 BC093914.1 BC094803.1 BC101517.1 
BC131530.1 

17 DOTS entries:

DT.114031  DT.95170396  DT.101972169  DT.99935414  DT.100024384  DT.100690178  DT.216144  DT.100758122 
DT.97822631  DT.97813902  DT.91740632  DT.120972500  DT.120972755  DT.120973045  DT.95170395  DT.120972576 
DT.91845606 

24/258 AceView cDNA sequences (see all 258 ):

AL831830 BX112560 T33386 AW083393 BM982404 BU429684 AY169244 Z39531 
BE501304 BF035341 AL120133 NM_032932 AA563715 Z42981 BQ188378 BE746924 
AI937421 AW751140 AL521106 AA829491 AA370382 AA458869 F06254 BC047674 

highest scoring ESTs for RAB11FIP4:

AI937421 AL120133 W22455 AA075467 AA126299 AA223580 AA232276 AA232354 AA278477 AA279012 

Unigene Cluster for RAB11FIP4:

RAB11 family interacting protein 4 (class II)
Hs.406788  [show with all ESTs]
Unigene Representative Sequence: NM_032932


GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for RAB11FIP4 (see all 8 )

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^
SP1:                                                                                                                                                            
SP2:              -     -                       -     -     -                                                                                                   
SP3:                                            -     -     -                                                                                                   
SP4:                                                                                                                                                            
SP5:                                            -     -     -                                                                                                   

ExUns: 18 ^ 19
SP1:            
SP2:            
SP3:            
SP4:            
SP5:            

About this scheme

ECgene alternative splicing isoforms for RAB11FIP4

3 Ensembl transcripts including schematic representations:
ENST00000394742  ENST00000394744  ENST00000325874  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

RAB11FIP4 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for RAB11FIP4

1 / 2 / 3

10 probe-sets matching RAB11FIP4 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
51240_at2, 3 U95-B 1 1.00 1.00 0.73 1.35 W22455 1.00 1.00 1.00 1
91576_at2, 3 U95-E 1 1.00 1.00 0.90 0.99 T66260 0.60 1.00 0.82 1

44752_at2, 3 U95-B 1 1.00 1.00 0.89 0.33 AI937421 1.00 1.00 1.00 1

55015_at2, 3 U95-B 1 1.00 1.00 0.95 1.46 AL120133 1.00 1.00 1.00 1

224482_s_at2, 3 U133-B 1 1.00 1.00 -- -- BC006240 0.80 1.00 0.91 1

225739_at2, 3 U133-B 1 1.00 1.00 -- -- BF064276 0.80 1.00 0.91 1

225746_at2, 3 U133-B 1 0.73 1.00 -- -- BG248313 0.40 1.00 0.76 1

224482_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

225739_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

225746_at2 U133Plus2 1 0.73 1.00 -- -- -- -- -- -- --
GeneDecks  RAB11FIP4 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: GTACTTACCT

SOURCE GeneReport for Unigene cluster: Hs.406788
(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for RAB11FIP4 gene from 5/8 species (see all 8 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
RAB11FIP41   -- RAB11 family interacting protein 4 (class II) 90.01(n)
94.55(a)
491159  XM_548279.2  XP_548279.2 
chimpanzee
(Pan troglodytes)
RAB11FIP41   -- RAB11 family interacting protein 4 (class II) 99.83(n)
100(a)
468383  XM_523772.2  XP_523772.2 
cow
(Bos taurus)
RAB11FIP41   -- RAB11 family interacting protein 4 (class II) 90.28(n)
94.69(a)
508331  XM_585093.3  XP_585093.3 
rat
(Rattus norvegicus)
Rab11fip41   -- RAB11 family interacting protein 4 (class II) 88.57(n)
93.4(a)
303337  XM_220737.4  XP_220737.4 
mouse
(Mus musculus)
Rab11fip41, 5 11 (46.15 cM)5
RAB11 family interacting protein 4 (class II)1, 5 87.96(n)1
93.22(a)1
2684511  NM_175543.31  NP_780752.11 
 AI4139005  AK0432295  (see all 17)
About this table        Species with no ortholog for RAB11FIP4

ENSEMBL Gene Tree for RAB11FIP4
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for RAB11FIP4 gene
RAB11FIP32  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/978 NCBI SNPs in RAB11FIP4 are shown (see all 978 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 247)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 17 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs15484711,2
A,C,F,H,O26887119(+) ATCCTA/GCTCAC 1 -- ut31 ese37Minor allele frequency- G:0.28NA MN EU EA WA 630
rs7573751,2
A,C,F,H26742005(+) CCCGGC/GGAAAG 1 -- ng515Minor allele frequency- G:0.45MN EU EA WA 602
rs72214071,2
A,C,F,H26883584(+) TCCCCG/ATTTCT 1 -- ut31 ese34Minor allele frequency- A:0.08EU EA WA 412
rs15484701,2
A,C,F,H26886982(+) CAGCCG/ACAGAA 1 -- ut31 ese35Minor allele frequency- A:0.30MN EU EA WA 596
rs15513591,2
A,C,F,O26887999(-) TCTACA/GCTTTT 1 -- ut31 ese31Minor allele frequency- G:0.41MN 184
rs72136251,2
A,F,H26885965(+) TTTCTG/ATAGTA 1 -- ut31 ese34Minor allele frequency- A:0.02EU EA WA 410
rs22904361,2
C,F,H26883626(-) AATGAA/CGCAGT 1 -- ut31 ese38Minor allele frequency- C:0.40EA NA EU WA 2034
rs15513561,2
A,C,F26888126(-) GCTGGT/CAGCTC 1 -- ut31 ese31Minor allele frequency- C:0.46MN 184
rs19921,2
C,F,H26883136(+) GGGAGG/AAGGCA 1 -- ut31 ese36Minor allele frequency- A:0.26MN EU EA WA 590
rs47956151,2
A,C,F26884772(+) TTTATC/ATGTAA 1 -- ut311Minor allele frequency- A:0.46MN 184
About this table

HapMap Linkage Disequilibrium images for RAB11FIP4 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 611999

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/13 PubMed articles for RAB11FIP4 gene (see all 13 ):
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 84440 HGNC: 30267 AceView: RAB11FIP4 Ensembl:ENSG00000131242 euGenes: HUgn84440
ECgene: RAB11FIP4 H-InvDB: RAB11FIP4
(According to HUGE)
About This Section

HUGE: KIAA1821
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
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  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for RAB11FIP4:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



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