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Aliases for RAB11FIP4 Gene

Aliases for RAB11FIP4 Gene

  • RAB11 Family Interacting Protein 4 2 3 5
  • RAB11 Family Interacting Protein 4 (Class II) 2 3
  • Arfophilin-2 3 4
  • RAB11-FIP4 3 4
  • FIP4-Rab11 3 4
  • Rab11 Family-Interacting Protein 4 3
  • KIAA1821 4
  • ARFO2 4

External Ids for RAB11FIP4 Gene

Previous GeneCards Identifiers for RAB11FIP4 Gene

  • GC17P026742
  • GC17P029718
  • GC17P025912

Summaries for RAB11FIP4 Gene

Entrez Gene Summary for RAB11FIP4 Gene

  • The protein encoded by this gene interacts with RAB11 and is thought to be involved in bringing recycling endosome membranes to the cleavage furrow in late cytokinesis. Hypoxic conditions can lead to an upregulation of the encoded protein and enhance the metastatic potential of hepatocellular carcinoma. [provided by RefSeq, Oct 2016]

GeneCards Summary for RAB11FIP4 Gene

RAB11FIP4 (RAB11 Family Interacting Protein 4) is a Protein Coding gene. Among its related pathways are Endocytosis. GO annotations related to this gene include calcium ion binding and Rab GTPase binding. An important paralog of this gene is RAB11FIP3.

UniProtKB/Swiss-Prot for RAB11FIP4 Gene

  • Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an address tag delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. In case of infection by HCMV (human cytomegalovirus), may participate in egress of the virus out of nucleus; this function is independent of ARF6.

Gene Wiki entry for RAB11FIP4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB11FIP4 Gene

Genomics for RAB11FIP4 Gene

Regulatory Elements for RAB11FIP4 Gene

Enhancers for RAB11FIP4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G031486 1.7 FANTOM5 ENCODE dbSUPER 27.9 +100.1 100135 10.5 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 ZNF143 ZNF207 FOS RAB11FIP4 EVI2B ENSG00000266490 LRRC37B LOC105371722 SUZ12P1 EVI2A SUZ12 GC17P031509 RN7SL79P
GH17G031416 1 ENCODE dbSUPER 39.1 +25.0 24984 0.2 SOX5 SOX13 GATAD2A TFAP4 SAP130 FOXA3 PPARG ZIC2 ZGPAT POLR2A RAB11FIP4 LOC105371725
GH17G031450 1.6 FANTOM5 Ensembl ENCODE dbSUPER 19.9 +60.4 60359 2.3 RAD21 GLIS2 ZNF366 RELB IKZF2 DEK ZNF654 ZNF362 REST CREB3 RAB11FIP4 RN7SL79P LOC105371725
GH17G031498 1.4 Ensembl ENCODE dbSUPER 18.4 +108.4 108398 2.1 ELF3 PKNOX1 FOXA2 CREM EGR2 MXD4 PPARG ZNF843 PRDM6 SMARCA4 RAB11FIP4 LRRC37BP1 GC17P031509 RN7SL79P
GH17G031592 1.7 FANTOM5 Ensembl ENCODE dbSUPER 14.5 +204.7 204656 6.7 TBP PKNOX1 FOXA2 SIN3A ZNF48 RAD21 GATA2 FOS IKZF2 CEBPB RAB11FIP4 MIR193A RNU6ATAC7P RNF135 CRLF3 EVI2A ENSG00000266877 GC17M031638 PIR51917
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RAB11FIP4 on UCSC Golden Path with GeneCards custom track

Promoters for RAB11FIP4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000093092 76 601 HDAC2 ZNF398 EZH2

Genomic Location for RAB11FIP4 Gene

Chromosome:
17
Start:
31,391,624 bp from pter
End:
31,538,217 bp from pter
Size:
146,594 bases
Orientation:
Plus strand

Genomic View for RAB11FIP4 Gene

Genes around RAB11FIP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB11FIP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB11FIP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB11FIP4 Gene

Proteins for RAB11FIP4 Gene

  • Protein details for RAB11FIP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YS3-RFIP4_HUMAN
    Recommended name:
    Rab11 family-interacting protein 4
    Protein Accession:
    Q86YS3
    Secondary Accessions:
    • Q52LI1
    • Q8N829
    • Q8NDT7
    • Q969D8

    Protein attributes for RAB11FIP4 Gene

    Size:
    637 amino acids
    Molecular mass:
    71928 Da
    Quaternary structure:
    • Homodimer. Forms a complex with Rab11 (RAB11A or RAB11B) and ARF6. Interacts with RAB11A; the interaction is direct. Forms a heterooligomeric complex with RAB11FIP2, RAB11FIP3 and RAB11FIP5. Interacts with HCMV (human cytomegalovirus) gM/UL100. Interacts with ECM29.

    Alternative splice isoforms for RAB11FIP4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAB11FIP4 Gene

Post-translational modifications for RAB11FIP4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RAB11FIP4 Gene

Domains & Families for RAB11FIP4 Gene

Gene Families for RAB11FIP4 Gene

Protein Domains for RAB11FIP4 Gene

Suggested Antigen Peptide Sequences for RAB11FIP4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86YS3

UniProtKB/Swiss-Prot:

RFIP4_HUMAN :
  • The RBD-FIP domain mediates the interaction with Rab11 (RAB11A or RAB11B).
Domain:
  • The RBD-FIP domain mediates the interaction with Rab11 (RAB11A or RAB11B).
genes like me logo Genes that share domains with RAB11FIP4: view

Function for RAB11FIP4 Gene

Molecular function for RAB11FIP4 Gene

UniProtKB/Swiss-Prot Function:
Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an address tag delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. In case of infection by HCMV (human cytomegalovirus), may participate in egress of the virus out of nucleus; this function is independent of ARF6.

Gene Ontology (GO) - Molecular Function for RAB11FIP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 12470645
GO:0017137 Rab GTPase binding IPI 12470645
GO:0030306 ADP-ribosylation factor binding IPI 16148947
GO:0042803 protein homodimerization activity IDA 12470645
genes like me logo Genes that share ontologies with RAB11FIP4: view
genes like me logo Genes that share phenotypes with RAB11FIP4: view

Animal Model Products

CRISPR Products

miRNA for RAB11FIP4 Gene

miRTarBase miRNAs that target RAB11FIP4

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB11FIP4 Gene

Localization for RAB11FIP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB11FIP4 Gene

Endosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Recycling endosome membrane; Peripheral membrane protein. Cleavage furrow. Midbody. Cytoplasmic vesicle. Note=Recruited to the cleavage furrow and the midbody during cytokinesis. {ECO:0000269 PubMed:15601896}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB11FIP4 gene
Compartment Confidence
extracellular 5
endosome 5
cytoskeleton 3
nucleus 2
cytosol 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RAB11FIP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0005737 cytoplasm IEA --
GO:0005768 endosome IDA,IEA 20682791
GO:0005815 microtubule organizing center IEA --
GO:0005819 spindle IEA --
genes like me logo Genes that share ontologies with RAB11FIP4: view

Pathways & Interactions for RAB11FIP4 Gene

SuperPathways for RAB11FIP4 Gene

SuperPathway Contained pathways
1 Endocytosis
genes like me logo Genes that share pathways with RAB11FIP4: view

Pathways by source for RAB11FIP4 Gene

1 KEGG pathway for RAB11FIP4 Gene

Interacting Proteins for RAB11FIP4 Gene

Gene Ontology (GO) - Biological Process for RAB11FIP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000910 cytokinesis IMP 16148947
GO:0003407 neural retina development IEA --
GO:0006810 transport IEA --
GO:0016032 viral process IEA --
GO:1903452 positive regulation of G1 to G0 transition IEA --
genes like me logo Genes that share ontologies with RAB11FIP4: view

No data available for SIGNOR curated interactions for RAB11FIP4 Gene

Drugs & Compounds for RAB11FIP4 Gene

(1) Drugs for RAB11FIP4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RAB11FIP4: view

Transcripts for RAB11FIP4 Gene

Unigene Clusters for RAB11FIP4 Gene

RAB11 family interacting protein 4 (class II):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB11FIP4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^
SP1:
SP2: - - - - -
SP3: - - -
SP4:
SP5: - - -
SP6: -
SP7:
SP8:

ExUns: 18 ^ 19
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for RAB11FIP4 Gene

GeneLoc Exon Structure for
RAB11FIP4
ECgene alternative splicing isoforms for
RAB11FIP4

Expression for RAB11FIP4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAB11FIP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB11FIP4 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.1), Brain - Putamen (basal ganglia) (x4.0), and Brain - Cortex (x4.0).

Protein differential expression in normal tissues from HIPED for RAB11FIP4 Gene

This gene is overexpressed in Lung (45.0) and Pancreas (19.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RAB11FIP4 Gene



Protein tissue co-expression partners for RAB11FIP4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RAB11FIP4 Gene:

RAB11FIP4

SOURCE GeneReport for Unigene cluster for RAB11FIP4 Gene:

Hs.406788

mRNA Expression by UniProt/SwissProt for RAB11FIP4 Gene:

Q86YS3-RFIP4_HUMAN
Tissue specificity: Present at high level in testis (at protein level). Weakly expressed in other tissues.

Evidence on tissue expression from TISSUES for RAB11FIP4 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with RAB11FIP4: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RAB11FIP4 Gene

Orthologs for RAB11FIP4 Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB11FIP4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB11FIP4 34 35
  • 99.83 (n)
dog
(Canis familiaris)
Mammalia RAB11FIP4 34 35
  • 90.01 (n)
cow
(Bos Taurus)
Mammalia RAB11FIP4 34 35
  • 89.95 (n)
rat
(Rattus norvegicus)
Mammalia Rab11fip4 34
  • 88.57 (n)
mouse
(Mus musculus)
Mammalia Rab11fip4 34 16 35
  • 87.96 (n)
oppossum
(Monodelphis domestica)
Mammalia RAB11FIP4 35
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAB11FIP4 35
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAB11FIP4 34 35
  • 72.76 (n)
lizard
(Anolis carolinensis)
Reptilia RAB11FIP4 35
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rab11fip4 34
  • 70.93 (n)
zebrafish
(Danio rerio)
Actinopterygii rab11fip4a 34 35
  • 69.42 (n)
rab11fip4b 35
  • 66 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta nuf 35
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F55C12.1 35
  • 21 (a)
OneToMany
Species where no ortholog for RAB11FIP4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB11FIP4 Gene

ENSEMBL:
Gene Tree for RAB11FIP4 (if available)
TreeFam:
Gene Tree for RAB11FIP4 (if available)

Paralogs for RAB11FIP4 Gene

Paralogs for RAB11FIP4 Gene

(1) SIMAP similar genes for RAB11FIP4 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with RAB11FIP4: view

Variants for RAB11FIP4 Gene

Sequence variations from dbSNP and Humsavar for RAB11FIP4 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs193921026 Uncertain significance 31,531,719(+) CCTCG(A/T)GATCA reference, missense
rs1000006490 -- 31,424,413(+) GCTTT(A/C)GTGGC intron-variant
rs1000017331 -- 31,463,228(+) TTGAG(A/C)CCCAG intron-variant
rs1000077843 -- 31,463,774(+) GTTGG(A/G)ATTAC intron-variant
rs1000093376 -- 31,504,117(+) TATAA(C/T)GTTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB11FIP4 Gene

Variant ID Type Subtype PubMed ID
esv2536682 CNV deletion 19546169
esv2678438 CNV deletion 23128226
esv2715819 CNV deletion 23290073
esv28654 CNV loss 19812545
esv3306010 CNV mobile element insertion 20981092
esv3371262 CNV insertion 20981092
esv3423217 CNV insertion 20981092
esv3640364 CNV loss 21293372
esv3640365 CNV loss 21293372
nsv1064728 CNV gain 25217958
nsv1070823 CNV deletion 25765185
nsv111881 CNV deletion 16902084
nsv1134638 CNV deletion 24896259
nsv1144796 CNV deletion 24896259
nsv475696 CNV novel sequence insertion 20440878
nsv478766 CNV novel sequence insertion 20440878
nsv519930 CNV loss 19592680
nsv522350 CNV loss 19592680
nsv827946 CNV gain 20364138
nsv827947 CNV gain 20364138
nsv833413 CNV gain+loss 17160897
nsv953877 CNV deletion 24416366

Variation tolerance for RAB11FIP4 Gene

Residual Variation Intolerance Score: 16.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.87; 35.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAB11FIP4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAB11FIP4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB11FIP4 Gene

Disorders for RAB11FIP4 Gene

Relevant External Links for RAB11FIP4

Genetic Association Database (GAD)
RAB11FIP4
Human Genome Epidemiology (HuGE) Navigator
RAB11FIP4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAB11FIP4

No disorders were found for RAB11FIP4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB11FIP4 Gene

Publications for RAB11FIP4 Gene

  1. Complete physical map and gene content of the human NF1 tumor suppressor region in human and mouse. (PMID: 12696059) Jenne D.E. … Kehrer-Sawatzki H. (Genes Chromosomes Cancer 2003) 3 4 22 64
  2. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components. (PMID: 20682791) Gorbea C. … Rechsteiner M. (J. Biol. Chem. 2010) 3 4 64
  5. The FIP3-Rab11 protein complex regulates recycling endosome targeting to the cleavage furrow during late cytokinesis. (PMID: 15601896) Wilson G.M. … Prekeris R. (Mol. Biol. Cell 2005) 3 4 64

Products for RAB11FIP4 Gene

Sources for RAB11FIP4 Gene

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