 |
 | Services
| |
 |
Aliases & Descriptions for RAB11FIP4
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| FLJ00131 1, 2 | | KIAA1821 1, 2, 3, 5 | | MGC11316 1, 2 | | MGC126566 2 | | RAB11-FIP4 1, 2 | | Rab11-FIP4 3 |
| | | Descriptions |
|---|
| RAB11 family interacting protein 4 (class II) 2 |
|
| | Search outside databases for aliases for RAB11FIP4 gene |
Summaries for RAB11FIP4(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for RAB11FIP4: Proteins of the large Rab GTPase family (see RAB1A; MIM 179508) have regulatory roles in the formation, targeting, and fusion of intracellular transport vesicles. RAB11FIP4 is one of many proteins that interact with and regulate Rab GTPases (Hales et al., 2001 [PubMed 11495908]).[supplied by OMIM] UniProtKB/Swiss-Prot: RFIP4_HUMAN, Q86YS3Function: A Rab11 effector protein acting in the endosomal traffickingGene Wiki entry for RAB11FIP4 |
Genomic Location for RAB11FIP4
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the RAB11FIP4 gene 
Entrez Gene cytogenetic band: 17q11.2 Ensembl cytogenetic band: 17q11.2 HGNC cytogenetic band: 17q11.2RAB11FIP4 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P026742:
(about GC identifiers)
Start:
|
26,742,768 bp from pter |
End:
|
26,889,356 bp from pter |
Size:
|
146,589 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000017.9 NT_010799.14
| Proteins for RAB11FIP4
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: RFIP4_HUMAN, Q86YS3 (See
protein sequence)Recommended Name: Rab11 family-interacting protein 4 Size: 637 amino acids; 71928 Da
Subunit: Homooligomer. Forms an heterooligomeric complex with RAB11FIP2, RAB11FIP3 and RAB11FIP5. Interacts with RAB11A that has been activated by GTP binding
Subcellular location: Recycling endosome membrane; Peripheral membrane protein. Note=Colocalizes with RAB11A in the endocytic recycling compartment (ERC)
Secondary accessions: Q52LI1 Q8N829 Q8NDT7 Q969D8Alternative splicing: 2 isoforms: Q86YS3-1 Q86YS3-2 REFSEQ proteins: NP_116321.2
ENSEMBL proteins: ENSP00000378225 ENSP00000378227 ENSP00000312837
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for RAB11FIP4: Assays for RAB11FIP4: | Protein
Domains/ Families for RAB11FIP4(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q86YS3
ProtoNet protein and cluster: Q86YS3 UniProtKB/Swiss-Prot: RFIP4_HUMAN, Q86YS3Similarity: Contains 1 EF-hand domain | Gene Function for RAB11FIP4
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_032932
Applied Biosystems Silencer® siRNAs for RAB11FIP4
Sigma-Aldrich siRNA for RAB11FIP4  Sigma-Aldrich shRNA for RAB11FIP4  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_032932                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_032932                                  untagged cDNA clones in CMV expression vector (see all 4): BC006240 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_032932
UniProtKB/Swiss-Prot: RFIP4_HUMAN, Q86YS3Function: A Rab11 effector protein acting in the endosomal trafficking1 Gene Ontology (GO) molecular function term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005509 | calcium ion binding |
IEA | -- | About this table | Pathways & Interactions for RAB11FIP4
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/10 Interacting proteins for RAB11FIP4 (ENSP000003128373) via UniProtKB, MINT, and/or STRING (see all 10
)About this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0015031 | protein transport |
IEA | -- | About this table
|
Drugs & Compounds for RAB11FIP4(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for RAB11FIP4
|
Transcripts for RAB11FIP4(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_032932
Sigma-Aldrich siRNA for RAB11FIP4  Sigma-Aldrich shRNA for RAB11FIP4  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_032932 REFSEQ mRNAs for RAB11FIP4 gene: NM_032932.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_032932               OriGene GFP tagged cDNA clone in CMV expression vector: NM_032932                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_032932                                  untagged cDNA clones in CMV expression vector (see all 4): BC006240  Additional cDNA sequence: AB058724.1 AJ314646.2 AK055019.1 AK074060.1 AK074341.1 AK097424.1 AL359563.2 AL831830.1 AY169244.1 BC004515.2 BC006240.2 BC023618.2 BC047674.2 BC093914.1 BC094803.1 BC101517.1 BC131530.1 17 DOTS entries: DT.114031 DT.95170396 DT.101972169 DT.99935414 DT.100024384 DT.100690178 DT.216144 DT.100758122 DT.97822631 DT.97813902 DT.91740632 DT.120972500 DT.120972755 DT.120973045 DT.95170395 DT.120972576 DT.91845606 24/258 AceView cDNA sequences (see all 258
):AL831830 BX112560 T33386 AW083393 BM982404 BU429684 AY169244 Z39531 BE501304 BF035341 AL120133 NM_032932 AA563715 Z42981 BQ188378 BE746924 AI937421 AW751140 AL521106 AA829491 AA370382 AA458869 F06254 BC047674
highest scoring ESTs for RAB11FIP4:AI937421 AL120133 W22455 AA075467 AA126299 AA223580 AA232276 AA232354 AA278477 AA279012 Unigene Cluster for RAB11FIP4: RAB11 family interacting protein 4 (class II) Hs.406788 [show with all ESTs]Unigene Representative Sequence: NM_032932
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for RAB11FIP4 (see all 8
)
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17 | ^ | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | - |   | - |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
| ExUns: | 18 | ^ | 19 | |
| SP1: | |   | |   | |
| SP2: | |   | |   | |
| SP3: | |   | |   | |
| SP4: | |   | |   | |
| SP5: | |   | |   |
About this scheme
ECgene alternative splicing isoforms for RAB11FIP4
3 Ensembl transcripts including schematic representations: ENST00000394742
ENST00000394744
ENST00000325874
|
Expression for RAB11FIP4
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| RAB11FIP4 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for RAB11FIP4
1 / 2 / 3 10 probe-sets matching RAB11FIP4 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GTACTTACCT
SOURCE GeneReport for Unigene cluster: Hs.406788
|
Orthologs for RAB11FIP4
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for RAB11FIP4 gene from 5/8 species (see all 8
)
About this table Species with no ortholog for RAB11FIP4
ENSEMBL Gene Tree for RAB11FIP4 | Paralogs for RAB11FIP4(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for RAB11FIP4 gene
- RAB11FIP32
|
SNPs/Variants for RAB11FIP4(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for RAB11FIP4 (up to first 250kb)
|
Disorders & Mutations for RAB11FIP4
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 611999
|
Medical News for RAB11FIP4(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for RAB11FIP4 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/13 PubMed articles for RAB11FIP4 gene (see all 13
):- Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)2, 3, 4 Nagase T....Ohara O. (2001)
- Complete physical map and gene content of the human NF1 tumor suppressor region in human and mouse. (PubMed id 12696059)1, 3, 4 Jenne D.E....Kehrer-Sawatzki H. (2003)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and its overexpression condenses the Rab11 positive compartment in HeLa cells. (PubMed id 12470645)3, 4 Wallace D.M.... McCaffrey M.W. (2002)
- Molecular characterization and gene content of breakpoint boundaries in patients with neurofibromatosis type 1 with 17q11.2 microdeletions. (PubMed id 11468690)2, 3 Jenne D.E....Kehrer-Sawatzki H. (2001)
- Mutations in RNF135, a gene within the NF1 microdeletion region, cause phenotypic abnormalities including overgrowth. (PubMed id 17632510)3 Douglas J....Rahman N. (2007)
- The full-ORF clone resource of the German cDNA Consortium. (PubMed id 17974005)4 Bechtel S....Schupp I. (2007)
- A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)3 Lim J....Zoghbi H.Y. (2006)
- Rab11-FIP3 and FIP4 interact with Arf6 and the exocyst to control membrane traffic in cytokinesis. (PubMed id 16148947)3 Fielding A.B....Gould G.W. (2005)
|
Search for RAB11FIP4
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing RAB11FIP4
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing RAB11FIP4
(According to HUGE)
About This Section
| |
Specialized Databases showing RAB11FIP4(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for RAB11FIP4(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for RAB11FIP4:

|
GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
|