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RAB11FIP3 Gene

protein-coding   GIFtS: 55
GCID: GC16P000475

RAB11 Family Interacting Protein 3 (Class II)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RAB11 Family Interacting Protein 3 (Class II)1 2     Cytoplasmic Adaptor For RAR And TR2
FIP3-Rab112 3     eferin2
MU-MB-17.1482 3     Rab11 Family-Interacting Protein 32
Rab11-FIP32 3     Rab11-Family Interacting Protein 32
EF Hands-Containing Rab-Interacting Protein2 3     ARFO13
KIAA06653 5     Arfophilin-13
CART12     Eferin3
PAC196A12.12     EFERIN5
arfophilin-12     

External Ids:    HGNC: 172241   Entrez Gene: 97272   Ensembl: ENSG000000905657   OMIM: 6087385   UniProtKB: O751543   

Export aliases for RAB11FIP3 gene to outside databases

Previous GC identifers: GC16P000416 GC16P000394


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RAB11FIP3 Gene:
Proteins of the large Rab GTPase family (see RAB1A; MIM 179508) have regulatory roles in the formation, targeting,
and fusion of intracellular transport vesicles. RAB11FIP3 is one of many proteins that interact with and regulate
Rab GTPases (Hales et al., 2001 (PubMed 11495908)).(supplied by OMIM, Mar 2008)

GeneCards Summary for RAB11FIP3 Gene:
RAB11FIP3 (RAB11 family interacting protein 3 (class II)) is a protein-coding gene. Diseases associated with RAB11FIP3 include large cell medulloblastoma, and childhood medulloblastoma. GO annotations related to this gene include Rab GTPase binding and calcium ion binding. An important paralog of this gene is RAB11FIP4.

UniProtKB/Swiss-Prot: RFIP3_HUMAN, O75154
Function: Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the
abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to
the cleavage furrow during late cytokinesis. Also required for the structural integrity of the endosomal
recycling compartment during interphase. May play a role in breast cancer cell motility by regulating actin
cytoskeleton

Gene Wiki entry for RAB11FIP3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NT_010393.17  NT_187610.1  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RAB11FIP3 gene promoter:
         c-Fos   AP-1   JunB   Fra-1   FosB   Nkx2-5   C/EBPalpha   CREB   JunD   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RAB11FIP3 promoter sequence
   Search Chromatin IP Primers for RAB11FIP3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RAB11FIP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

RAB11FIP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAB11FIP3 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P000475:  view genomic region     (about GC identifiers)

Start:
475,619 bp from pter      End:
573,011 bp from pter
Size:
97,393 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RFIP3_HUMAN, O75154 (See protein sequence)
Recommended Name: Rab11 family-interacting protein 3  
Size: 756 amino acids; 82440 Da
Subunit: Homodimer. Forms a complex with Rab11 (RAB11A or RAB11B) and ARF6. Interacts with RAB11A; the interaction
is direct. Interacts with RAB11B, RAB25 and RAB11FIP4. Interacts with ARF6; according to PubMed:16148947, it
specifically interacts with ARF6 but not ARF5. Interacts with ARF6; according to PubMed:17030804 but not
PubMed:16148947. Interacts with RACGAP1/MgcRacGAP; interaction takes place during late stage of cytokinesis and
is required for recruitment to the midbody. Interacts with ASAP1 and EXOC7
Sequence caution: Sequence=BAA31640.2; Type=Erroneous initiation; Sequence=BAG57098.1; Type=Erroneous initiation;
Sequence=CAQ09358.1; Type=Erroneous gene model prediction; Sequence=CAQ09642.1; Type=Erroneous gene model
prediction; Sequence=CAQ11003.1; Type=Erroneous gene model prediction;
2 PDB 3D structures from and Proteopedia for RAB11FIP3:
2D7C (3D)        2HV8 (3D)    
Secondary accessions: B0QYI8 B0QYT8 B1AHQ0 B4DEI7 B4DZR6 Q4VXV7 Q7Z5E9 Q9H155 Q9H1G0 Q9NUI0
Alternative splicing: 3 isoforms:  O75154-1   O75154-2   O75154-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RAB11FIP3: NX_O75154

Explore proteomics data for RAB11FIP3 at MOPED

Post-translational modifications: 

  • Phosphorylated at Ser-102 by CDK1 during metaphase, and dephosphorylated as cells enter telophase1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RAB11FIP3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001135744.1  NP_055515.1  

    ENSEMBL proteins: 
     ENSP00000262305   ENSP00000399644   ENSP00000399614   ENSP00000404331   ENSP00000412502  
     ENSP00000398730   ENSP00000415919  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    EFHAND: EF-hand domain containing

    3 InterPro protein domains:
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom
     IPR019018 Rab-bd_FIP-RBD

    Graphical View of Domain Structure for InterPro Entry O75154

    ProtoNet protein and cluster: O75154

    UniProtKB/Swiss-Prot: RFIP3_HUMAN, O75154
    Domain: The RBD-FIP domain mediates the interaction with Rab11 (RAB11A or RAB11B)
    Similarity: Contains 2 EF-hand domains
    Similarity: Contains 1 FIP-RBD domain


    RAB11FIP3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RFIP3_HUMAN, O75154
    Function: Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the
    abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to
    the cleavage furrow during late cytokinesis. Also required for the structural integrity of the endosomal
    recycling compartment during interphase. May play a role in breast cancer cell motility by regulating actin
    cytoskeleton

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI12470645
    GO:0017137Rab GTPase binding NAS11481332
    GO:0030306ADP-ribosylation factor binding IPI16148947
    GO:0042803protein homodimerization activity IDA17030804
         
    RAB11FIP3 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Rab11fip3 (no phenotypes)

    RAB11FIP3 for phenotypes           About GeneDecksing

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    SwitchGear 3'UTR luciferase reporter plasmidRAB11FIP3 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RFIP3_HUMAN, O75154: Recycling endosome membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton,
    microtubule organizing center, centrosome. Cleavage furrow. Midbody. Note=In early mitosis remains diffuse and
    distributed through the cell. The onset of anaphase sequesters these vesicles to the centrosomes at the opposite
    poles of the cell. During telophase these vesicles move from the centrosomes, to the furrow, and then to the
    midbody to aid in abscission. Interaction with Rab11 mediates localization to endosomes. Interaction with ARF6
    mediates localization to the midbody
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    endosome5
    nucleus4
    cytosol2
    extracellular1
    golgi apparatus1

    Gene Ontology (GO): Selected cellular component terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005768endosome IDA15601896
    GO:0005813centrosome IDA15601896
    GO:0005815microtubule organizing center IDA--

    RAB11FIP3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RAB11FIP3 About    
    See pathways by source

    SuperPathContained pathways About
    1Endocytosis
    Endocytosis
    2Arf6 downstream pathway
    Arf6 downstream pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for RAB11FIP3
        Arf6 downstream pathway


    1 Kegg Pathway  (Kegg details for RAB11FIP3):
        Endocytosis


    RAB11FIP3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RAB11FIP3
    Interactions:

        Search GeneGlobe Interaction Network for RAB11FIP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for RAB11FIP3 (O751541, 2, 3 ENSP000002623054) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RACGAP1Q9H0H51, 2, 3, ENSP000003098714EBI-7942186,EBI-717233 MINT-6799593 MINT-6799707 MINT-6799722 MINT-6799583 MINT-6799628 MINT-6799646 MINT-6799664 I2D: score=1 STRING: ENSP00000309871
    RAB11AP624912, 3, ENSP000002618904MINT-6799685 I2D: score=3 STRING: ENSP00000261890
    RAB11BQ159073, ENSP000003335474I2D: score=2 STRING: ENSP00000333547
    TOMM34Q157853, ENSP000003619004I2D: score=1 STRING: ENSP00000361900
    RAB25P577353, ENSP000003543764I2D: score=2 STRING: ENSP00000354376
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000910cytokinesis IMP15601896
    GO:0016192vesicle-mediated transport TAS16148947
    GO:0032456endocytic recycling IDA17394487

    RAB11FIP3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for RAB11FIP3 (RFIP3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RAB11FIP3 gene (2 alternative transcripts): 
    NM_001142272.1  NM_014700.3  

    Unigene Cluster for RAB11FIP3:

    RAB11 family interacting protein 3 (class II)
    Hs.531642  [show with all ESTs]
    Unigene Representative Sequence: NM_014700
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262305(uc002chf.3) ENST00000434585 ENST00000452814 ENST00000483002
    ENST00000449879 ENST00000412256 ENST00000495663 ENST00000487899 ENST00000461009
    ENST00000464263 ENST00000457159(uc010uug.2) ENST00000450428(uc010uuf.2)

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    Additional mRNA sequence: 

    AB014565.1 AF038180.1 AF395731.1 AK094817.1 AK293644.1 AK303061.1 AY130007.1 BC051360.1 

    12 DOTS entries:

    DT.453218  DT.95348290  DT.100033502  DT.70105242  DT.100672693  DT.100814842  DT.97845974  DT.40278844 
    DT.100814844  DT.120710577  DT.303298  DT.95367285 

    Selected AceView cDNA sequences (see all 245):

    CA395186 AI253065 BM711142 BM678760 BQ684196 NM_014700 BF197481 BQ674858 
    AF395731 BF510355 AA480381 CF143567 BQ054166 BM709104 BQ892572 BC051360 
    AI264640 AI824935 CF143192 AW469744 BQ069630 AW024849 AW499645 CA438411 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RAB11FIP3 (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
    SP1:                          -     -     -                       -     -                                                                           
    SP2:                                                                                                                                                
    SP3:                          -     -     -                                                                                                         
    SP4:                                                              -     -                                                                           
    SP5:                                      -                       -     -                                                                           


    ECgene alternative splicing isoforms for RAB11FIP3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RAB11FIP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACTCCCAGG
    RAB11FIP3 Expression
    About this image


    RAB11FIP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Retinal Pigmented Epithelium
     
     Kidney (Urinary System)
    RAB11FIP3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RAB11FIP3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.531642
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RAB11FIP3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rab11fip31 , 5 RAB11 family interacting protein 3 (class II)1, 5 84.48(n)1
    88.1(a)1
      17 (13.05 cM)5
    2154451  NM_001162869.11  NP_001156341.11 
     259890365 
    chicken
    (Gallus gallus)
    Aves LOC1008572691 rab11 family-interacting protein 3-like 75.92(n)
    73.88(a)
      100857269  XM_004945419.1  XP_004945476.1 
    lizard
    (Anolis carolinensis)
    Reptilia RAB11FIP36
    RAB11 family interacting protein 3 (class II)
    71(a)
    1 ↔ 1
    GL343989.1(50455-93233)
    zebrafish
    (Danio rerio)
    Actinopterygii rab11fip36
    RAB11 family interacting protein 3 (class II)
    19(a)
    1 ↔ 1
    24(39226376-39301267) ENSDARG00000016490
    fruit fly
    (Drosophila melanogaster)
    Insecta nuf6
    nuclear fallout
    19(a)
    1 → many
    3L(14183970-14226350)
    worm
    (Caenorhabditis elegans)
    Secernentea F55C12.16
    Protein F55C12.1, isoform a (F55C12.1) mRNA, compl...
    18(a)
    1 → many
    II(5884552-5892675) WBGene00018869


    ENSEMBL Gene Tree for RAB11FIP3 (if available)
    TreeFam Gene Tree for RAB11FIP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RAB11FIP3 gene
    RAB11FIP42  
    1 SIMAP similar gene for RAB11FIP3 using alignment to 4 protein entries:     RFIP3_HUMAN (see all proteins):
    RAB11FIP4

    RAB11FIP3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RAB11FIP3 (see all 2395)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs109030161,2
    C,F,A,H--473723(+) CCGCCT/CGCCTC 1 -- us2k17Minor allele frequency- C:0.24NA WA CSA 17
    rs1929234661,2
    --473773(+) CACCTA/GGCCTA 1 -- us2k10--------
    rs1855518561,2
    --473844(+) TGCACC/TGCAGC 1 -- us2k10--------
    rs2003091101,2
    --473877(+) GTCTC-/GGGGAA 1 -- us2k10--------
    rs1144855151,2
    C--473880(+) TCGGGA/GAAAAA 1 -- us2k10--------
    rs579849491,2
    C--473893(+) GAAAAAAAGA   
       AAA
    /-
    GAAAA
    1 -- us2k11Minor allele frequency- -:0.00NA 2
    rs780257811,2
    C--473894(+) GAAAAA/GAAAAG 1 -- us2k10--------
    rs96742941,2
    C,F,H--473930(+) AGCCTA/TCAAAG 1 -- us2k1 tfbs35Minor allele frequency- T:0.04NS EA WA 536
    rs1144095631,2
    C,F--473974(+) ATAGAC/TGGGAA 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1879866991,2
    --474129(+) CTGCTC/TTCAGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RAB11FIP3 (475619 - 573011 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for RAB11FIP3 (see all 49):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2660167CNV Deletion23128226
    esv2674251CNV Deletion23128226
    esv2661719CNV Deletion23128226
    esv2750199CNV Deletion23290073
    esv2668893CNV Deletion23128226
    esv2658752CNV Deletion23128226
    esv2750198CNV Deletion23290073
    esv2750195CNV Deletion23290073
    esv2750201CNV Deletion23290073
    esv2750200CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RAB11FIP3
    DNA2.0 Custom Variant and Variant Library Synthesis for RAB11FIP3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608738    OMIM disorders: --

    6 diseases for RAB11FIP3:    
    About MalaCards
    large cell medulloblastoma    childhood medulloblastoma    medulloblastoma    thyroiditis
    retinitis    breast cancer


    RAB11FIP3 for disorders           About GeneDecksing


    Export disorders for RAB11FIP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RAB11FIP3 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with RAB11FIP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel Rab11/25 binding domain present in eferin and rip proteins. (PubMed id 11481332)1, 2, 3, 9 Prekeris R.... Scheller R.H. (J. Biol. Chem. 2001)
    2. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2, 3 Ishikawa K.... Ohara O. (DNA Res. 1998)
    3. Rab11-FIP3 localises to a Rab11-positive pericentrosomal compartment during interphase and to the cleavage furrow during cytokinesis. (PubMed id 15158446)1, 2, 9 Horgan C.P.... McCaffrey M.W. (Biochem. Biophys. Res. Commun. 2004)
    4. Rab11-FIP3 is a Rab11-binding protein that regulates breast cancer cell motility by modulating the actin cytoskeleton. (PubMed id 19327867)1, 2, 9 Jing J.... Prekeris R. (Eur. J. Cell Biol. 2009)
    5. Sequential Cyk-4 binding to ECT2 and FIP3 regulates cleavage furrow ingression and abscission during cytokinesis. (PubMed id 18511905)1, 2 Simon G.C.... Prekeris R. (EMBO J. 2008)
    6. Molecular characterization of Rab11-FIP3 binding to ARF GTPases. (PubMed id 17628206)1, 2 Schonteich E.... Prekeris R. (Eur. J. Cell Biol. 2007)
    7. Rab11-FIP3 is critical for the structural integrity of the endosomal recycling compartment. (PubMed id 17394487)1, 2 Horgan C.P.... McCaffrey M.W. (Traffic 2007)
    8. Structural basis for Rab11-dependent membrane recruitment of a family of Rab11-interacting protein 3 (FIP3)/Arfophilin-1. (PubMed id 17030804)1, 2 Shiba T....Wakatsuki S. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    9. Structural basis for Rab11-mediated recruitment of FIP3 to recycling endosomes. (PubMed id 17007872)1, 2 Eathiraj S.... Lambright D.G. (J. Mol. Biol. 2006)
    10. The FIP3-Rab11 protein complex regulates recycling endosome targeting to the cleavage furrow during late cytokinesis. (PubMed id 15601896)1, 2 Wilson G.M.... Prekeris R. (Mol. Biol. Cell 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9727 HGNC: 17224 AceView: RAB11FIP3 Ensembl:ENSG00000090565 euGenes: HUgn9727
    ECgene: RAB11FIP3 Kegg: 9727 H-InvDB: RAB11FIP3

    (According to HUGE)
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    HUGE: KIAA0665

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RAB11FIP3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RAB11FIP3 gene:
    Search GeneIP for patents involving RAB11FIP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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