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Aliases for RAB11FIP3 Gene

Aliases for RAB11FIP3 Gene

  • RAB11 Family Interacting Protein 3 (Class II) 2 3
  • Arfophilin-1 2 3 4
  • Eferin 3 4 6
  • EF Hands-Containing Rab-Interacting Protein 3 4
  • MU-MB-17.148 3 4
  • FIP3-Rab11 3 4
  • Rab11-FIP3 3 4
  • KIAA0665 4 6
  • Cytoplasmic Adaptor For RAR And TR 3
  • Rab11 Family-Interacting Protein 3 3
  • Rab11-Family Interacting Protein 3 3
  • PAC196A12.1 3
  • CART1 3
  • ARFO1 4

External Ids for RAB11FIP3 Gene

Summaries for RAB11FIP3 Gene

Entrez Gene Summary for RAB11FIP3 Gene

  • Proteins of the large Rab GTPase family (see RAB1A; MIM 179508) have regulatory roles in the formation, targeting, and fusion of intracellular transport vesicles. RAB11FIP3 is one of many proteins that interact with and regulate Rab GTPases (Hales et al., 2001 [PubMed 11495908]).[supplied by OMIM, Mar 2008]

GeneCards Summary for RAB11FIP3 Gene

RAB11FIP3 (RAB11 Family Interacting Protein 3 (Class II)) is a Protein Coding gene. Diseases associated with RAB11FIP3 include medulloblastoma. Among its related pathways are Endocytosis and Arf6 downstream pathway. GO annotations related to this gene include calcium ion binding and Rab GTPase binding.

UniProtKB/Swiss-Prot for RAB11FIP3 Gene

  • Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an address tag delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. Also required for the structural integrity of the endosomal recycling compartment during interphase. May play a role in breast cancer cell motility by regulating actin cytoskeleton.

Gene Wiki entry for RAB11FIP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB11FIP3 Gene

Genomics for RAB11FIP3 Gene

Genomic Location for RAB11FIP3 Gene

Start:
425,619 bp from pter
End:
523,011 bp from pter
Size:
97,393 bases
Orientation:
Plus strand

Genomic View for RAB11FIP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAB11FIP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB11FIP3 Gene

Regulatory Elements for RAB11FIP3 Gene

Proteins for RAB11FIP3 Gene

  • Protein details for RAB11FIP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75154-RFIP3_HUMAN
    Recommended name:
    Rab11 family-interacting protein 3
    Protein Accession:
    O75154
    Secondary Accessions:
    • B0QYI8
    • B0QYT8
    • B1AHQ0
    • B4DEI7
    • B4DZR6
    • Q4VXV7
    • Q7Z5E9
    • Q9H155
    • Q9H1G0
    • Q9NUI0

    Protein attributes for RAB11FIP3 Gene

    Size:
    756 amino acids
    Molecular mass:
    82440 Da
    Quaternary structure:
    • Homodimer. Forms a complex with Rab11 (RAB11A or RAB11B) and ARF6. Interacts with RAB11A; the interaction is direct. Interacts with RAB11B, RAB25 and RAB11FIP4. Interacts with ARF6; according to PubMed:16148947, it specifically interacts with ARF6 but not ARF5. Interacts with ARF6; according to PubMed:17030804 but not PubMed:16148947. Interacts with RACGAP1/MgcRacGAP; interaction takes place during late stage of cytokinesis and is required for recruitment to the midbody. Interacts with ASAP1 and EXOC7.
    SequenceCaution:
    • Sequence=BAA31640.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG57098.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAQ09358.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAQ09642.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAQ11003.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RAB11FIP3 Gene

    Alternative splice isoforms for RAB11FIP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAB11FIP3 Gene

Proteomics data for RAB11FIP3 Gene at MOPED

Post-translational modifications for RAB11FIP3 Gene

  • Phosphorylated at Ser-102 by CDK1 during metaphase, and dephosphorylated as cells enter telophase.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB11FIP3 Gene

No data available for DME Specific Peptides for RAB11FIP3 Gene

Domains for RAB11FIP3 Gene

Gene Families for RAB11FIP3 Gene

HGNC:
  • EFHAND :EF-hand domain containing

Protein Domains for RAB11FIP3 Gene

UniProtKB/Swiss-Prot:

RFIP3_HUMAN
Domain:
  • The RBD-FIP domain mediates the interaction with Rab11 (RAB11A or RAB11B).:
    • O75154
  • Contains 2 EF-hand domains.:
    • O75154
  • Contains 1 FIP-RBD domain.:
    • O75154
genes like me logo Genes that share domains with RAB11FIP3: view

Function for RAB11FIP3 Gene

Molecular function for RAB11FIP3 Gene

UniProtKB/Swiss-Prot Function: Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an address tag delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. Also required for the structural integrity of the endosomal recycling compartment during interphase. May play a role in breast cancer cell motility by regulating actin cytoskeleton.

Gene Ontology (GO) - Molecular Function for RAB11FIP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 12470645
GO:0017137 Rab GTPase binding NAS 11481332
GO:0030306 ADP-ribosylation factor binding IPI 16148947
GO:0042803 protein homodimerization activity IDA 17030804
genes like me logo Genes that share ontologies with RAB11FIP3: view

miRNA for RAB11FIP3 Gene

miRTarBase miRNAs that target RAB11FIP3

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RAB11FIP3 Gene

Localization for RAB11FIP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB11FIP3 Gene

Recycling endosome membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cleavage furrow. Midbody. Note=In early mitosis remains diffuse and distributed through the cell. The onset of anaphase sequesters these vesicles to the centrosomes at the opposite poles of the cell. During telophase these vesicles move from the centrosomes, to the furrow, and then to the midbody to aid in abscission. Interaction with Rab11 mediates localization to endosomes. Interaction with ARF6 mediates localization to the midbody.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB11FIP3 Gene COMPARTMENTS Subcellular localization image for RAB11FIP3 gene
Compartment Confidence
cytoskeleton 5
endosome 5
nucleus 4
cytosol 2
extracellular 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for RAB11FIP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005768 endosome IDA 15601896
GO:0005813 centrosome IDA 15601896
GO:0005815 microtubule organizing center IDA --
genes like me logo Genes that share ontologies with RAB11FIP3: view

Pathways for RAB11FIP3 Gene

SuperPathways for RAB11FIP3 Gene

genes like me logo Genes that share pathways with RAB11FIP3: view

Pathways by source for RAB11FIP3 Gene

1 BioSystems pathway for RAB11FIP3 Gene
1 KEGG pathway for RAB11FIP3 Gene

Gene Ontology (GO) - Biological Process for RAB11FIP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000910 cytokinesis IMP 15601896
GO:0006996 organelle organization TAS --
GO:0016192 vesicle-mediated transport TAS 16148947
GO:0032456 endocytic recycling IDA 17394487
GO:0070164 negative regulation of adiponectin secretion IDA 24040321
genes like me logo Genes that share ontologies with RAB11FIP3: view

Transcripts for RAB11FIP3 Gene

Unigene Clusters for RAB11FIP3 Gene

RAB11 family interacting protein 3 (class II):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAB11FIP3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: - - - - -
SP2:
SP3: - - -
SP4: - -
SP5: - - -
SP6: - - - -
SP7: -
SP8: -

Relevant External Links for RAB11FIP3 Gene

GeneLoc Exon Structure for
RAB11FIP3
ECgene alternative splicing isoforms for
RAB11FIP3

Expression for RAB11FIP3 Gene

mRNA expression in normal human tissues for RAB11FIP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB11FIP3 Gene

SOURCE GeneReport for Unigene cluster for RAB11FIP3 Gene Hs.531642

genes like me logo Genes that share expressions with RAB11FIP3: view

Orthologs for RAB11FIP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB11FIP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB11FIP3 36
  • 99.63 (n)
  • 99.78 (a)
RAB11FIP3 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RAB11FIP3 36
  • 83.69 (n)
  • 81.55 (a)
RAB11FIP3 37
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAB11FIP3 36
  • 87.23 (n)
  • 87.76 (a)
RAB11FIP3 37
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rab11fip3 36
  • 84.48 (n)
  • 88.1 (a)
Rab11fip3 16
Rab11fip3 37
  • 48 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAB11FIP3 37
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAB11FIP3 37
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rab11fip3 36
  • 84.48 (n)
  • 88.49 (a)
chicken
(Gallus gallus)
Aves LOC100857269 36
  • 75.92 (n)
  • 73.88 (a)
RAB11FIP3 37
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAB11FIP3 37
  • 71 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii rab11fip3 37
  • 19 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta nuf 37
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F55C12.1 37
  • 18 (a)
OneToMany
Species with no ortholog for RAB11FIP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RAB11FIP3 Gene

ENSEMBL:
Gene Tree for RAB11FIP3 (if available)
TreeFam:
Gene Tree for RAB11FIP3 (if available)

Paralogs for RAB11FIP3 Gene

Selected SIMAP similar genes for RAB11FIP3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RAB11FIP3: view

No data available for Paralogs for RAB11FIP3 Gene

Variants for RAB11FIP3 Gene

Sequence variations from dbSNP and Humsavar for RAB11FIP3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs730699 -- 500,871(+) GCTCA(A/G)AAGTG intron-variant
rs754295 -- 488,565(-) CAGGC(A/G)TGGAT intron-variant
rs926694 -- 477,961(+) GTGAG(A/G)CGAGA intron-variant
rs1054334 -- 521,904(+) GCCTG(C/T)GCTTC utr-variant-3-prime
rs1122690 -- 501,100(-) ATAAA(C/T)GCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB11FIP3 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
dgv32n68 CNV Loss 17160897
dgv2469n71 CNV Loss 21882294
dgv2473n71 CNV Loss 21882294
nsv904707 CNV Loss 21882294
dgv2474n71 CNV Loss 21882294
nsv904709 CNV Gain+Loss 21882294
nsv457303 CNV Loss 19166990
nsv904715 CNV Gain 21882294
nsv9320 CNV Loss 18304495
esv2660167 CNV Deletion 23128226
nsv521610 CNV Gain 19592680
esv2642014 CNV Insertion 19546169
esv2658752 CNV Deletion 23128226
nsv904716 CNV Loss 21882294
nsv528354 CNV Loss 19592680
nsv526903 CNV Loss 19592680
dgv2475n71 CNV Loss 21882294
nsv103435 CNV Loss 16902084
esv1003529 CNV Insertion 20482838
nsv1700 CNV Insertion 18451855
esv1053020 CNV Insertion 17803354
esv21550 CNV Gain 19812545
dgv2476n71 CNV Loss 21882294
esv2674251 CNV Deletion 23128226
esv2750195 CNV Deletion 23290073
esv2668893 CNV Deletion 23128226
esv1621246 CNV Insertion 17803354
nsv1701 CNV Insertion 18451855
dgv2477n71 CNV Loss 21882294
dgv2478n71 CNV Gain+Loss 21882294
dgv2479n71 CNV Loss 21882294
esv2750197 CNV Deletion 23290073
esv1206343 CNV Insertion 17803354
esv2750198 CNV Deletion 23290073
esv2661719 CNV Deletion 23128226
esv1572768 CNV Insertion 17803354
esv2750199 CNV Deletion 23290073
esv26517 CNV Gain 19812545
esv2750200 CNV Deletion 23290073
esv2750201 CNV Deletion 23290073
dgv2480n71 CNV Loss 21882294
nsv833113 CNV Loss 17160897
nsv833114 CNV Gain+Loss 17160897
esv24273 CNV Gain 19812545
nsv904729 CNV Loss 21882294
dgv2481n71 CNV Loss 21882294
nsv471064 CNV Gain 18288195
nsv471063 CNV Loss 18288195

Relevant External Links for RAB11FIP3 Gene

HapMap Linkage Disequilibrium report
RAB11FIP3

Disorders for RAB11FIP3 Gene

(1) MalaCards Diseases for RAB11FIP3 Gene

Search for RAB11FIP3 Gene in MalaCards »
genes like me logo Genes that share disorders with RAB11FIP3: view

No data available for UniProtKB/Swiss-Prot for RAB11FIP3 Gene

Publications for RAB11FIP3 Gene

  1. Identification of a novel Rab11/25 binding domain present in eferin and rip proteins. (PMID: 11481332) Prekeris R. … Scheller R.H. (J. Biol. Chem. 2001) 2 3 4 23
  2. Rab11-FIP3 localises to a Rab11-positive pericentrosomal compartment during interphase and to the cleavage furrow during cytokinesis. (PMID: 15158446) Horgan C.P. … McCaffrey M.W. (Biochem. Biophys. Res. Commun. 2004) 3 4 23
  3. Rab11-FIP3 is a Rab11-binding protein that regulates breast cancer cell motility by modulating the actin cytoskeleton. (PMID: 19327867) Jing J. … Prekeris R. (Eur. J. Cell Biol. 2009) 3 4 23
  4. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 2 3 4
  5. Identification of a protein that interacts with the vanilloid receptor. (PMID: 15883036) Lee S.Y. (Biochem. Biophys. Res. Commun. 2005) 3 23

Products for RAB11FIP3 Gene

Sources for RAB11FIP3 Gene

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