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Aliases & Descriptions for RAB11FIP3
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases EFERIN 5 Eferin 3 KIAA0665 1 , 2 , 3 , 5 PAC196A12.1 2 Rab11-FIP3 1 , 2 , 3 eferin 1 , 2
Descriptions EF hands-containing Rab-interacting protein 3 RAB11 family interacting protein 3 (class II) 2 rab11-family interacting protein 3 2
Search outside databases for aliases for RAB11FIP3 gene
Summaries for RAB11FIP3 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for RAB11FIP3 : Proteins of the large Rab GTPase family (see RAB1A; MIM 179508) have regulatory roles in theformation, targeting, and fusion of intracellular transport vesicles. RAB11FIP3 is one of manyproteins that interact with and regulate Rab GTPases (Hales et al., 2001 [PubMed11495908]).[supplied by OMIM] Gene Wiki entry for RAB11FIP3
Genomic Location for RAB11FIP3
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the RAB11FIP3 gene Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3 RAB11FIP3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure
GeneLoc location for GC16P000416:
(about GC identifiers )
Start:
415,669 bp from pter
End:
512,482 bp from pter
Size:
96,814 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000016.8 NT_037887.4 Proteins for RAB11FIP3
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
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R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
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Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: RFIP3_HUMAN, O75154 (See
protein sequence )Recommended Name: Rab11 family-interacting protein 3 Size : 756 amino acids; 82440 Da
Subunit : Forms an heterooligomeric complex with RAB11FIP4. Binds to RAB11A, RAB11B and RAB25
Subcellular location : Recycling endosome. Note=Colocalizes with RAB11A at recycling endosomes
PDB structure from and Proteopedia : 2D7C (3D)
 2HV8 (3D)
 
Secondary accessions : Q4VXV7 Q9H155 Q9H1G0 Q9NUI0
REFSEQ proteins (2 alternative transcripts):
NP_001135744.1 NP_055515.1 ENSEMBL proteins: ENSP00000262305 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 1 Gene Ontology (GO) cellular component term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0055037 recycling endosome
IEA --
About this table Antibodies for RAB11FIP3: Assays for RAB11FIP3:
Protein
Domains/ Families for RAB11FIP3(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry O75154 ProtoNet protein and cluster: O75154
UniProtKB/Swiss-Prot: RFIP3_HUMAN, O75154 Similarity : Contains 2 EF-hand domains
Gene Function for RAB11FIP3
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
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Clones , and
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SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_001142272 Applied Biosystems Silencer ® siRNAs for RAB11FIP3 Sigma-Aldrich siRNA for RAB11FIP3 Sigma-Aldrich shRNA Panels and shRNA for RAB11FIP3 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001142272                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001142272                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001142272  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_014700 2 Gene Ontology (GO) molecular function terms (links to tree view) :
About this table
Pathways & Interactions for RAB11FIP3
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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4 Interacting proteins for RAB11FIP3 (O75154 2 ) via UniProtKB, MINT, and/or STRING About this table 1 Gene Ontology (GO) biological process term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0015031 protein transport
IEA --
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Drugs & Compounds for RAB11FIP3 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for RAB11FIP3
Transcripts for RAB11FIP3(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_001142272 Sigma-Aldrich siRNA for RAB11FIP3 Sigma-Aldrich shRNA Panels and shRNA for RAB11FIP3 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001142272 NM_014700
REFSEQ mRNAs for RAB11FIP3 gene (2 alternative transcripts): NM_001142272.1 NM_014700.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001142272 NM_014700
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001142272                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001142272                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001142272  
Additional cDNA sequence: AB014565.1 AF038180.1 AF395731.1 AK094817.1 AK293644.1 AK303061.1 AY130007.1 BC051360.1 CR622821.1 Z36827.1
12 DOTS entries : DT.453218 DT.95348290 DT.100033502 DT.70105242 DT.100672693 DT.100814842 DT.40278844 DT.97845974 DT.95367285 DT.100814844 DT.120710577 DT.303298
24/245 AceView cDNA sequences (see all 245
):AW304845 BQ674858 AI128222 F11160 AW444991 BQ212638 BM705075 BX509467 BM681294 CA395186 BQ054166 BQ101082 CA430823 BF510355 BQ921593 AI824935 CR622821 BQ684196 AW499645 BM711142 NM_014700 BM709104 AW469744 AA988359
highest scoring ESTs for RAB11FIP3 :AA055405 AA323921 AA425081 AA480381 AA873410 AA932923 AA962448 AB014565 AF038180 AF395731
Unigene Cluster for RAB11FIP3: RAB11 family interacting protein 3 (class II) Hs.531642 [show with all ESTs ] Unigene Representative Sequence: NM_014700 GeneLoc Exon Structure 5/8 Alternative Splicing Database (ASD) splice patterns (SP) for RAB11FIP3 (see all 8
) ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 SP1 :         -   -   -         -   -                           SP2 :                                                 SP3 :         -   -   -                                     SP4 :                     -   -                           SP5 :             -         -   -                          
About this scheme ECgene alternative splicing isoforms for RAB11FIP3 1 Ensembl transcript including schematic representation : ENST00000262305
Expression for RAB11FIP3
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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RAB11FIP3 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for RAB11FIP3 1 / 2 / 3
12 probe-sets matching RAB11FIP3 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: GACTCCCAGGSOURCE GeneReport for Unigene cluster: Hs.531642 Expression variation in blood from EXPOLDB for RAB11FIP3
Orthologs for RAB11FIP3
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
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Gene Trees according to Ensembl )
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Orthologs for RAB11FIP3 gene from 3 species
About this table Species with no ortholog for RAB11FIP3 ENSEMBL Gene Tree for RAB11FIP3 Paralogs for RAB11FIP3 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for RAB11FIP3 gene RAB11FIP4 2
SNPs/Variants for RAB11FIP3 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for RAB11FIP3 (up to first 250kb)
Disorders & Mutations for RAB11FIP3
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
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and/or TGDB .)
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OMIM: 608738
Medical News for RAB11FIP3 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for RAB11FIP3 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/19 PubMed articles for RAB11FIP3 gene (see all 19
): Identification of a novel Rab11/25 binding domain present in Eferin and Rip proteins. (PubMed id 11481332) 1, 2, 3, 4 Prekeris R....Scheller R.H. (2001) Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811) 2, 3, 4 Ishikawa K....Ohara O. (1998) The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553) 3, 4 Martin J.... Pennacchio L.A. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and its overexpression condenses the Rab11 positive compartment in HeLa cells. (PubMed id 12470645) 3, 4 Wallace D.M.... McCaffrey M.W. (2002) Identification and characterization of a family of Rab11-interacting proteins. (PubMed id 11495908) 3, 4 Hales C.M....Goldenring J.R. (2001) Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PubMed id 11157797) 3, 4 Daniels R.J....Higgs D.R. (2001) Rab11-FIP3 localises to a Rab11-positive pericentrosomal compartment during interphase and to the cleavage furrow during cytokinesis. (PubMed id 15158446) 1, 3 Horgan C.P....McCaffrey M.W. (2004) Molecular characterization of Rab11-FIP3 binding to ARF GTPases. (PubMed id 17628206) 3 Schonteich E....Prekeris R. (2007) Rab11-FIP3 is critical for the structural integrity of the endosomal recycling compartment. (PubMed id 17394487) 3 Horgan C.P....McCaffrey M.W. (2007)
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Genome Databases showing RAB11FIP3
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and/or
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Other Databases showing RAB11FIP3
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Specialized Databases showing RAB11FIP3 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for RAB11FIP3 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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