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Aliases for RAB11FIP3 Gene

Aliases for RAB11FIP3 Gene

  • RAB11 Family Interacting Protein 3 2
  • RAB11 Family Interacting Protein 3 (Class II) 2 3 5
  • Arfophilin-1 2 3 4
  • EF Hands-Containing Rab-Interacting Protein 3 4
  • MU-MB-17.148 3 4
  • FIP3-Rab11 3 4
  • Rab11-FIP3 3 4
  • Eferin 3 4
  • Cytoplasmic Adaptor For RAR And TR 3
  • Rab11-Family Interacting Protein 3 3
  • PAC196A12.1 3
  • KIAA0665 4
  • CART1 3
  • ARFO1 4

External Ids for RAB11FIP3 Gene

Previous GeneCards Identifiers for RAB11FIP3 Gene

  • GC16P000416
  • GC16P000475
  • GC16P000394

Summaries for RAB11FIP3 Gene

Entrez Gene Summary for RAB11FIP3 Gene

  • Proteins of the large Rab GTPase family (see RAB1A; MIM 179508) have regulatory roles in the formation, targeting, and fusion of intracellular transport vesicles. RAB11FIP3 is one of many proteins that interact with and regulate Rab GTPases (Hales et al., 2001 [PubMed 11495908]).[supplied by OMIM, Mar 2008]

GeneCards Summary for RAB11FIP3 Gene

RAB11FIP3 (RAB11 Family Interacting Protein 3) is a Protein Coding gene. Among its related pathways are Endocytosis and Organelle biogenesis and maintenance. GO annotations related to this gene include calcium ion binding and Rab GTPase binding. An important paralog of this gene is RAB11FIP4.

UniProtKB/Swiss-Prot for RAB11FIP3 Gene

  • Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an address tag delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. Also required for the structural integrity of the endosomal recycling compartment during interphase. May play a role in breast cancer cell motility by regulating actin cytoskeleton.

Gene Wiki entry for RAB11FIP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB11FIP3 Gene

Genomics for RAB11FIP3 Gene

Regulatory Elements for RAB11FIP3 Gene

Promoters for RAB11FIP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RAB11FIP3 on UCSC Golden Path with GeneCards custom track

Genomic Location for RAB11FIP3 Gene

Chromosome:
16
Start:
425,592 bp from pter
End:
523,011 bp from pter
Size:
97,420 bases
Orientation:
Plus strand

Genomic View for RAB11FIP3 Gene

Genes around RAB11FIP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB11FIP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB11FIP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB11FIP3 Gene

Proteins for RAB11FIP3 Gene

  • Protein details for RAB11FIP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75154-RFIP3_HUMAN
    Recommended name:
    Rab11 family-interacting protein 3
    Protein Accession:
    O75154
    Secondary Accessions:
    • B0QYI8
    • B0QYT8
    • B1AHQ0
    • B4DEI7
    • B4DZR6
    • Q4VXV7
    • Q7Z5E9
    • Q9H155
    • Q9H1G0
    • Q9NUI0

    Protein attributes for RAB11FIP3 Gene

    Size:
    756 amino acids
    Molecular mass:
    82440 Da
    Quaternary structure:
    • Homodimer. Forms a complex with Rab11 (RAB11A or RAB11B) and ARF6. Interacts with RAB11A; the interaction is direct. Interacts with RAB11B, RAB25 and RAB11FIP4. Interacts with ARF6; according to PubMed:16148947, it specifically interacts with ARF6 but not ARF5. Interacts with ARF6; according to PubMed:17030804 but not PubMed:16148947. Interacts with RACGAP1/MgcRacGAP; interaction takes place during late stage of cytokinesis and is required for recruitment to the midbody. Interacts with ASAP1 and EXOC7.
    SequenceCaution:
    • Sequence=BAA31640.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG57098.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAQ09358.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAQ09642.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAQ11003.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RAB11FIP3 Gene

    Alternative splice isoforms for RAB11FIP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAB11FIP3 Gene

Proteomics data for RAB11FIP3 Gene at MOPED

Post-translational modifications for RAB11FIP3 Gene

  • Phosphorylated at Ser-102 by CDK1 during metaphase, and dephosphorylated as cells enter telophase.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB11FIP3 Gene

Antibody Products

No data available for DME Specific Peptides for RAB11FIP3 Gene

Domains & Families for RAB11FIP3 Gene

Gene Families for RAB11FIP3 Gene

Protein Domains for RAB11FIP3 Gene

Graphical View of Domain Structure for InterPro Entry

O75154

UniProtKB/Swiss-Prot:

RFIP3_HUMAN :
  • The RBD-FIP domain mediates the interaction with Rab11 (RAB11A or RAB11B).
Domain:
  • The RBD-FIP domain mediates the interaction with Rab11 (RAB11A or RAB11B).
  • Contains 2 EF-hand domains.
  • Contains 1 FIP-RBD domain.
genes like me logo Genes that share domains with RAB11FIP3: view

Function for RAB11FIP3 Gene

Molecular function for RAB11FIP3 Gene

UniProtKB/Swiss-Prot Function:
Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an address tag delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. Also required for the structural integrity of the endosomal recycling compartment during interphase. May play a role in breast cancer cell motility by regulating actin cytoskeleton.

Gene Ontology (GO) - Molecular Function for RAB11FIP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042803 protein homodimerization activity IDA 17030804
genes like me logo Genes that share ontologies with RAB11FIP3: view
genes like me logo Genes that share phenotypes with RAB11FIP3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB11FIP3 Gene

Localization for RAB11FIP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB11FIP3 Gene

Recycling endosome membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cleavage furrow. Midbody. Note=In early mitosis remains diffuse and distributed through the cell. The onset of anaphase sequesters these vesicles to the centrosomes at the opposite poles of the cell. During telophase these vesicles move from the centrosomes, to the furrow, and then to the midbody to aid in abscission (PubMed:15158446, PubMed:15601896, PubMed:18511905). Interaction with Rab11 mediates localization to endosomes (PubMed:11495908). Interaction with ARF6 mediates localization to the midbody (PubMed:16148947). {ECO:0000269 PubMed:11495908, ECO:0000269 PubMed:15601896, ECO:0000269 PubMed:16148947, ECO:0000269 PubMed:18511905}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB11FIP3 Gene COMPARTMENTS Subcellular localization image for RAB11FIP3 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
endosome 5
extracellular 5
nucleus 5
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for RAB11FIP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005815 microtubule organizing center IDA --
GO:0030496 midbody IDA 15601896
GO:0032154 cleavage furrow IDA 15601896
GO:0055037 recycling endosome IDA 17394487
genes like me logo Genes that share ontologies with RAB11FIP3: view

Pathways & Interactions for RAB11FIP3 Gene

genes like me logo Genes that share pathways with RAB11FIP3: view

Pathways by source for RAB11FIP3 Gene

1 KEGG pathway for RAB11FIP3 Gene

Gene Ontology (GO) - Biological Process for RAB11FIP3 Gene

None

No data available for SIGNOR curated interactions for RAB11FIP3 Gene

Drugs & Compounds for RAB11FIP3 Gene

No Compound Related Data Available

Transcripts for RAB11FIP3 Gene

Unigene Clusters for RAB11FIP3 Gene

RAB11 family interacting protein 3 (class II):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAB11FIP3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: - - - - -
SP2:
SP3: - - -
SP4: - -
SP5: - - -
SP6: - - - -
SP7: -
SP8: -

Relevant External Links for RAB11FIP3 Gene

GeneLoc Exon Structure for
RAB11FIP3
ECgene alternative splicing isoforms for
RAB11FIP3

Expression for RAB11FIP3 Gene

mRNA expression in normal human tissues for RAB11FIP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RAB11FIP3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (58.3) and Platelet (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB11FIP3 Gene



SOURCE GeneReport for Unigene cluster for RAB11FIP3 Gene Hs.531642

genes like me logo Genes that share expression patterns with RAB11FIP3: view

Protein tissue co-expression partners for RAB11FIP3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RAB11FIP3 Gene

Orthologs for RAB11FIP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB11FIP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB11FIP3 35
  • 99.63 (n)
  • 99.78 (a)
RAB11FIP3 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RAB11FIP3 36
  • 71 (a)
OneToOne
RAB11FIP3 35
  • 83.69 (n)
  • 81.55 (a)
dog
(Canis familiaris)
Mammalia RAB11FIP3 35
  • 87.23 (n)
  • 87.76 (a)
RAB11FIP3 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rab11fip3 16
Rab11fip3 35
  • 84.48 (n)
  • 88.1 (a)
Rab11fip3 36
  • 48 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAB11FIP3 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAB11FIP3 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rab11fip3 35
  • 84.48 (n)
  • 88.49 (a)
chicken
(Gallus gallus)
Aves LOC100857269 35
  • 75.92 (n)
  • 73.88 (a)
RAB11FIP3 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAB11FIP3 36
  • 71 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii rab11fip3 36
  • 19 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta nuf 36
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F55C12.1 36
  • 18 (a)
OneToMany
Species with no ortholog for RAB11FIP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RAB11FIP3 Gene

ENSEMBL:
Gene Tree for RAB11FIP3 (if available)
TreeFam:
Gene Tree for RAB11FIP3 (if available)

Paralogs for RAB11FIP3 Gene

Paralogs for RAB11FIP3 Gene

(1) SIMAP similar genes for RAB11FIP3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RAB11FIP3: view

Variants for RAB11FIP3 Gene

Sequence variations from dbSNP and Humsavar for RAB11FIP3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs926694 -- 477,961(+) GTGAG(A/G)CGAGA intron-variant, downstream-variant-500B
rs1883891 -- 477,457(+) CGGAC(C/G)TGTGC intron-variant, upstream-variant-2KB
rs1698232 -- 435,555(+) AAGTT(C/T)TGAAG intron-variant
rs2071976 -- 514,881(+) AGGCA(C/T)AGAGT intron-variant
rs2071977 -- 515,561(+) CCACA(C/T)GGGCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB11FIP3 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
dgv32n68 CNV Loss 17160897
dgv2469n71 CNV Loss 21882294
dgv2473n71 CNV Loss 21882294
nsv904707 CNV Loss 21882294
dgv2474n71 CNV Loss 21882294
nsv904709 CNV Gain+Loss 21882294
nsv457303 CNV Loss 19166990
nsv904715 CNV Gain 21882294
nsv9320 CNV Loss 18304495
esv2660167 CNV Deletion 23128226
nsv521610 CNV Gain 19592680
esv2642014 CNV Insertion 19546169
esv2658752 CNV Deletion 23128226
nsv904716 CNV Loss 21882294
nsv528354 CNV Loss 19592680
nsv526903 CNV Loss 19592680
dgv2475n71 CNV Loss 21882294
nsv103435 CNV Loss 16902084
esv1003529 CNV Insertion 20482838
nsv1700 CNV Insertion 18451855
esv1053020 CNV Insertion 17803354
esv21550 CNV Gain 19812545
dgv2476n71 CNV Loss 21882294
esv2674251 CNV Deletion 23128226
esv2750195 CNV Deletion 23290073
esv2668893 CNV Deletion 23128226
esv1621246 CNV Insertion 17803354
nsv1701 CNV Insertion 18451855
dgv2477n71 CNV Loss 21882294
dgv2478n71 CNV Gain+Loss 21882294
dgv2479n71 CNV Loss 21882294
esv2750197 CNV Deletion 23290073
esv1206343 CNV Insertion 17803354
esv2750198 CNV Deletion 23290073
esv2661719 CNV Deletion 23128226
esv1572768 CNV Insertion 17803354
esv2750199 CNV Deletion 23290073
esv26517 CNV Gain 19812545
esv2750200 CNV Deletion 23290073
esv2750201 CNV Deletion 23290073
dgv2480n71 CNV Loss 21882294
nsv833113 CNV Loss 17160897
nsv833114 CNV Gain+Loss 17160897
esv24273 CNV Gain 19812545
nsv904729 CNV Loss 21882294
dgv2481n71 CNV Loss 21882294
nsv471064 CNV Gain 18288195
nsv471063 CNV Loss 18288195

Variation tolerance for RAB11FIP3 Gene

Residual Variation Intolerance Score: 41.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.88; 48.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAB11FIP3 Gene

HapMap Linkage Disequilibrium report
RAB11FIP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB11FIP3 Gene

Disorders for RAB11FIP3 Gene

Relevant External Links for RAB11FIP3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAB11FIP3

No disorders were found for RAB11FIP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB11FIP3 Gene

Publications for RAB11FIP3 Gene

  1. Identification of a novel Rab11/25 binding domain present in eferin and rip proteins. (PMID: 11481332) Prekeris R. … Scheller R.H. (J. Biol. Chem. 2001) 2 3 4 23 67
  2. Rab11-FIP3 is a Rab11-binding protein that regulates breast cancer cell motility by modulating the actin cytoskeleton. (PMID: 19327867) Jing J. … Prekeris R. (Eur. J. Cell Biol. 2009) 3 23
  3. Identification of a protein that interacts with the vanilloid receptor. (PMID: 15883036) Lee S.Y. (Biochem. Biophys. Res. Commun. 2005) 3 23
  4. Rab11-FIP3 localises to a Rab11-positive pericentrosomal compartment during interphase and to the cleavage furrow during cytokinesis. (PMID: 15158446) Horgan C.P. … McCaffrey M.W. (Biochem. Biophys. Res. Commun. 2004) 3 23
  5. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 2 3

Products for RAB11FIP3 Gene

Sources for RAB11FIP3 Gene

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