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RAB11FIP3 Gene

protein-coding GIFtS: 55
GCID: GC16P000475

RAB11 Family Interacting Protein 3 (Class II)

See RAB11FIP3-related disease
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
RAB11 Family Interacting Protein 3 (Class II)¹ ²		Cytoplasmic Adaptor For RAR And TR²
FIP3-Rab11² ³		eferin²
MU-MB-17.148² ³		Rab11 Family-Interacting Protein 3²
Rab11-FIP3² ³		Rab11-Family Interacting Protein 3²
EF Hands-Containing Rab-Interacting Protein² ³		ARFO1³
KIAA0665³ ⁵		Arfophilin-1³
CART1²		Eferin³
PAC196A12.1²		EFERIN⁵
arfophilin-1²

External Ids:	HGNC: 17224¹	Entrez Gene: 9727²	Ensembl: ENSG00000090565⁷	OMIM: 608738⁵	UniProtKB: O75154³

Export aliases for RAB11FIP3 gene to outside databases

Previous GC identifers: GC16P000416 GC16P000394

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RAB11FIP3 Gene:

Proteins of the large Rab GTPase family (see RAB1A; MIM 179508) have regulatory roles in the formation, targeting,

and fusion of intracellular transport vesicles. RAB11FIP3 is one of many proteins that interact with and regulate

Rab GTPases (Hales et al., 2001 (PubMed 11495908)).(supplied by OMIM, Mar 2008)

GeneCards Summary for RAB11FIP3 Gene:

RAB11FIP3 (RAB11 family interacting protein 3 (class II)) is a protein-coding gene. Diseases associated with RAB11FIP3 include medulloblastoma. GO annotations related to this gene include Rab GTPase binding and calcium ion binding. An important paralog of this gene is RAB11FIP4.

UniProtKB/Swiss-Prot: RFIP3_HUMAN, O75154

Function: Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the

abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to

the cleavage furrow during late cytokinesis. Also required for the structural integrity of the endosomal

recycling compartment during interphase. May play a role in breast cancer cell motility by regulating actin

cytoskeleton

Gene Wiki entry for RAB11FIP3 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000016.9 NT_010393.17 NT_187610.1 NC_018927.2

Regulatory elements:

Regulatory transcription factor binding sites in the RAB11FIP3 gene promoter:
c-Fos AP-1 JunB Fra-1 FosB Nkx2-5 C/EBPalpha CREB JunD c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RAB11FIP3 promoter sequence

Search Chromatin IP Primers for RAB11FIP3

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RAB11FIP3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3

RAB11FIP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAB11FIP3 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P000475: view genomic region (about GC identifiers)

Start:	475,619 bp from pter	End:	573,011 bp from pter
Size:	97,393 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

UniProtKB/Swiss-Prot: RFIP3_HUMAN, O75154 (See protein sequence)

Recommended Name: Rab11 family-interacting protein 3

Size: 756 amino acids; 82440 Da

Subunit: Homodimer. Forms a complex with Rab11 (RAB11A or RAB11B) and ARF6. Interacts with RAB11A; the interaction

is direct. Interacts with RAB11B, RAB25 and RAB11FIP4. Interacts with ARF6; according to PubMed:16148947, it

specifically interacts with ARF6 but not ARF5. Interacts with ARF6; according to PubMed:17030804 but not

PubMed:16148947. Interacts with RACGAP1/MgcRacGAP; interaction takes place during late stage of cytokinesis and

is required for recruitment to the midbody. Interacts with ASAP1 and EXOC7

Sequence caution: Sequence=BAA31640.2; Type=Erroneous initiation; Sequence=BAG57098.1; Type=Erroneous initiation;

Sequence=CAQ09358.1; Type=Erroneous gene model prediction; Sequence=CAQ09642.1; Type=Erroneous gene model

prediction; Sequence=CAQ11003.1; Type=Erroneous gene model prediction;

2 PDB 3D structures from and Proteopedia for RAB11FIP3:

2D7C (3D)

2HV8 (3D)

Secondary accessions: B0QYI8 B0QYT8 B1AHQ0 B4DEI7 B4DZR6 Q4VXV7 Q7Z5E9 Q9H155 Q9H1G0 Q9NUI0

Alternative splicing: 3 isoforms: O75154-1 O75154-2 O75154-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RAB11FIP3: NX_O75154

Explore proteomics data for RAB11FIP3 at MOPED

Post-translational modifications:

Phosphorylated at Ser-102 by CDK1 during metaphase, and dephosphorylated as cells enter telophase¹

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See RAB11FIP3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts):

NP_001135744.1 NP_055515.1

ENSEMBL proteins:

ENSP00000262305 ENSP00000399644 ENSP00000399614 ENSP00000404331 ENSP00000412502

ENSP00000398730 ENSP00000415919

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

HGNC Gene Families:

EFHAND: EF-hand domain containing

3 InterPro protein domains:

IPR011992 EF-hand-dom_pair

IPR002048 EF_hand_dom

IPR019018 Rab-bd_FIP-RBD

Graphical View of Domain Structure for InterPro Entry O75154

ProtoNet protein and cluster: O75154

UniProtKB/Swiss-Prot: RFIP3_HUMAN, O75154

Domain: The RBD-FIP domain mediates the interaction with Rab11 (RAB11A or RAB11B)

Similarity: Contains 2 EF-hand domains

Similarity: Contains 1 FIP-RBD domain

Find genes that share domains with RAB11FIP3 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: RFIP3_HUMAN, O75154

Function: Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the

abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to

the cleavage furrow during late cytokinesis. Also required for the structural integrity of the endosomal

recycling compartment during interphase. May play a role in breast cancer cell motility by regulating actin

cytoskeleton

Gene Ontology (GO): 5 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	IEA	--
GO:0005515	protein binding	IPI	12470645
GO:0017137	Rab GTPase binding	NAS	11481332
GO:0030306	ADP-ribosylation factor binding	IPI	16148947
GO:0042803	protein homodimerization activity	IDA	17030804

Find genes that share ontologies with RAB11FIP3 About GenesLikeMe

Phenotypes:
1 MGI phenotypic allele

for Rab11fip3 (no phenotypes)

Find genes that share phenotypes with RAB11FIP3 About GenesLikeMe

Animal Models:

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from UniProtKB/Swiss-Prot

RFIP3_HUMAN, O75154: Recycling endosome membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton,

microtubule organizing center, centrosome. Cleavage furrow. Midbody. Note=In early mitosis remains diffuse and

distributed through the cell. The onset of anaphase sequesters these vesicles to the centrosomes at the opposite

poles of the cell. During telophase these vesicles move from the centrosomes, to the furrow, and then to the

midbody to aid in abscission. Interaction with Rab11 mediates localization to endosomes. Interaction with ARF6

mediates localization to the midbody

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytoskeleton	5
endosome	5
nucleus	4
cytosol	2
extracellular	1
golgi apparatus	1

About this image

Gene Ontology (GO): Selected cellular component terms (see all 13): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005768	endosome	IDA	15601896
GO:0005813	centrosome	IDA	15601896
GO:0005815	microtubule organizing center	IDA	--

Find genes that share ontologies with RAB11FIP3 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

SuperPaths for RAB11FIP3 About

See pathways by source

Powered
by

SuperPath

Contained pathways About

Endocytosis

Endocytosis

Arf6 downstream pathway

Arf6 downstream pathway

Find genes that share SuperPaths with RAB11FIP3 About GenesLikeMe

Pathways by source See SuperPaths
Show all pathways

1 BioSystems Pathway for RAB11FIP3

Arf6 downstream pathway

1 Kegg Pathway (Kegg details for RAB11FIP3):

Endocytosis

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for RAB11FIP3
Interactions:

Search GeneGlobe Interaction Network for RAB11FIP3

STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

Selected Interacting proteins for RAB11FIP3 (O75154^{1, 2, 3} ENSP00000262305⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 15)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RACGAP1	Q9H0H5¹^,²^,³, ENSP00000309871⁴	EBI-7942186,EBI-717233 MINT-6799593 MINT-6799707 MINT-6799722 MINT-6799583 MINT-6799628 MINT-6799646 MINT-6799664 I2D: score=1 STRING: ENSP00000309871
RAB11A	P62491²^,³, ENSP00000261890⁴	MINT-6799685 I2D: score=3 STRING: ENSP00000261890
RAB11B	Q15907³, ENSP00000333547⁴	I2D: score=2 STRING: ENSP00000333547
TOMM34	Q15785³, ENSP00000361900⁴	I2D: score=1 STRING: ENSP00000361900
RAB25	P57735³, ENSP00000354376⁴	I2D: score=2 STRING: ENSP00000354376

About this table

Gene Ontology (GO): 3 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000910	cytokinesis	IMP	15601896
GO:0016192	vesicle-mediated transport	TAS	16148947
GO:0032456	endocytic recycling	IDA	17394487

Find genes that share ontologies with RAB11FIP3 About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

Browse Small Molecules at EMD Millipore

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Browse Tocris compounds for RAB11FIP3 (RFIP3)

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

REFSEQ mRNAs for RAB11FIP3 gene (16 alternative transcripts):

NM_001142272.1 NM_014700.3 XM_005255713.1 XM_005255714.1 XM_005255715.2 XM_005255717.1 XM_005255718.1 XM_006720987.1

XM_006720988.1 XM_006725242.1 XM_006725243.1 XM_006725244.1 XM_006725245.1 XM_006725246.1 XM_006725247.1 XM_006725248.1

Unigene Cluster for RAB11FIP3:

RAB11 family interacting protein 3 (class II)

Hs.531642 [show with all ESTs]

Unigene Representative Sequence: NM_014700

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000262305(uc002chf.3) ENST00000434585 ENST00000452814 ENST00000483002

ENST00000449879 ENST00000412256 ENST00000495663 ENST00000487899 ENST00000461009

ENST00000464263 ENST00000457159(uc010uug.2) ENST00000450428(uc010uuf.2)

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Additional mRNA sequence:

AB014565.1 AF038180.1 AF395731.1 AK094817.1 AK293644.1 AK303061.1 AY130007.1 BC051360.1

12 DOTS entries:

DT.453218 DT.95348290 DT.100033502 DT.70105242 DT.100672693 DT.100814842 DT.97845974 DT.40278844

DT.100814844 DT.120710577 DT.303298 DT.95367285

Selected AceView cDNA sequences (see all 245):

CA395186 AI253065 BM711142 BM678760 BQ684196 NM_014700 BF197481 BQ674858

AF395731 BF510355 AA480381 CF143567 BQ054166 BM709104 BQ892572 BC051360

AI264640 AI824935 CF143192 AW469744 BQ069630 AW024849 AW499645 CA438411

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for RAB11FIP3 (see all 8) About this scheme

ExUns:	1	^	2a	·	2b	^	3	^	4a	·	4b	·	4c	^	5	^	6a	·	6b	·	6c	^	7	^	8	^	9a	·	9b	^	10	^	11a	·	11b	·	11c	^	12	^	13	^	14	^	15	^	16
SP1:									-		-		-								-		-
SP2:
SP3:									-		-		-
SP4:																					-		-
SP5:													-								-		-

ECgene alternative splicing isoforms for RAB11FIP3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RAB11FIP3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GACTCCCAGG

About this image

RAB11FIP3 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 2) fully expand


Eye (Sensory Organs) fully expand to see all 2 entries
Retinal Pigmented Epithelium

Kidney (Urinary System)

RAB11FIP3 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

RAB11FIP3 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.531642

Custom PCR Arrays for RAB11FIP3

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for RAB11FIP3 gene from Selected species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Rab11fip3^{1 , 5}	RAB11 family interacting protein 3 (class II)^{1, 5}	84.48(n)¹ 88.1(a)¹		17 (13.05 cM)⁵ 215445¹ NM_001162869.1¹ NP_001156341.1¹ 25989036⁵
chicken (Gallus gallus)	Aves	LOC100857269¹	rab11 family-interacting protein 3-like	75.92(n) 73.88(a)		100857269 XM_004945419.1 XP_004945476.1
lizard (Anolis carolinensis)	Reptilia	RAB11FIP3⁶	RAB11 family interacting protein 3 (class II)	71(a)	1 ↔ 1	GL343989.1(50455-93233)
zebrafish (Danio rerio)	Actinopterygii	rab11fip3⁶	RAB11 family interacting protein 3 (class II)	19(a)	1 ↔ 1	24(39226376-39301267) ENSDARG00000016490
fruit fly (Drosophila melanogaster)	Insecta	nuf⁶	nuclear fallout	19(a)	1 → many	3L(14183970-14226350)
worm (Caenorhabditis elegans)	Secernentea	F55C12.1⁶	Protein F55C12.1, isoform a (F55C12.1) mRNA, compl...	18(a)	1 → many	II(5884552-5892675) WBGene00018869

ENSEMBL Gene Tree for RAB11FIP3 (if available)
TreeFam Gene Tree for RAB11FIP3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for RAB11FIP3 gene

RAB11FIP4²

1 SIMAP similar gene for RAB11FIP3 using alignment to 4 protein entries: RFIP3_HUMAN (see all proteins):

RAB11FIP4

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(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs10903016^1,2	C,F,A,H	--	473723(+)	`CCGCCT/CGCCTC`	1	--	us2k¹		7		NA WA CSA	17
rs192923466^1,2		--	473773(+)	`CACCTA/GGCCTA`	1	--	us2k¹		0	--	--	--	--
rs185551856^1,2		--	473844(+)	`TGCACC/TGCAGC`	1	--	us2k¹		0	--	--	--	--
rs200309110^1,2		--	473877(+)	`GTCTC-/GGGGAA`	1	--	us2k¹		0	--	--	--	--
rs114485515^1,2	C	--	473880(+)	`TCGGGA/GAAAAA`	1	--	us2k¹		0	--	--	--	--
rs57984949^1,2	C	--	473893(+)	`GAAAAAAAGA AAA/-GAAAA`	1	--	us2k¹		1		NA	2
rs78025781^1,2	C	--	473894(+)	`GAAAAA/GAAAAG`	1	--	us2k¹		0	--	--	--	--
rs9674294^1,2	C,F,H	--	473930(+)	`AGCCTA/TCAAAG`	1	--	us2k¹ tfbs³		5		NS EA WA	536
rs114409563^1,2	C,F	--	473974(+)	`ATAGAC/TGGGAA`	1	--	us2k¹		1		WA	118
rs187986699^1,2		--	474129(+)	`CTGCTC/TTCAGA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for RAB11FIP3 (475619 - 573011 bp)

Structural Variations
Database of Genomic Variants (DGV) Selected variations for RAB11FIP3 (see all 49): About this table

Variant ID	Type	Subtype	PubMed ID
esv2660167	CNV	Deletion	23128226
esv2674251	CNV	Deletion	23128226
esv2661719	CNV	Deletion	23128226
esv2750199	CNV	Deletion	23290073
esv2668893	CNV	Deletion	23128226
esv2658752	CNV	Deletion	23128226
esv2750198	CNV	Deletion	23290073
esv2750195	CNV	Deletion	23290073
esv2750201	CNV	Deletion	23290073
esv2750200	CNV	Deletion	23290073

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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OMIM gene information: 608738 OMIM disorders: --

1 disease for RAB11FIP3:
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medulloblastoma

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(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for RAB11FIP3 gene, integrated from 10 sources (see all 30):
(articles sorted by number of sources associating them with RAB11FIP3)

Identification of a novel Rab11/25 binding domain present in eferin and rip proteins. (PubMed id 11481332)^{1, 2, 3, 9} Prekeris R.... Scheller R.H. (J. Biol. Chem. 2001)
Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)^{1, 2, 3} Ishikawa K.... Ohara O. (DNA Res. 1998)
Rab11-FIP3 localises to a Rab11-positive pericentrosomal compartment during interphase and to the cleavage furrow during cytokinesis. (PubMed id 15158446)^{1, 2, 9} Horgan C.P.... McCaffrey M.W. (Biochem. Biophys. Res. Commun. 2004)
Rab11-FIP3 is a Rab11-binding protein that regulates breast cancer cell motility by modulating the actin cytoskeleton. (PubMed id 19327867)^{1, 2, 9} Jing J.... Prekeris R. (Eur. J. Cell Biol. 2009)
Sequential Cyk-4 binding to ECT2 and FIP3 regulates cleavage furrow ingression and abscission during cytokinesis. (PubMed id 18511905)^{1, 2} Simon G.C.... Prekeris R. (EMBO J. 2008)
Molecular characterization of Rab11-FIP3 binding to ARF GTPases. (PubMed id 17628206)^{1, 2} Schonteich E.... Prekeris R. (Eur. J. Cell Biol. 2007)
Rab11-FIP3 is critical for the structural integrity of the endosomal recycling compartment. (PubMed id 17394487)^{1, 2} Horgan C.P.... McCaffrey M.W. (Traffic 2007)
Structural basis for Rab11-dependent membrane recruitment of a family of Rab11-interacting protein 3 (FIP3)/Arfophilin-1. (PubMed id 17030804)^{1, 2} Shiba T....Wakatsuki S. (Proc. Natl. Acad. Sci. U.S.A. 2006)
Structural basis for Rab11-mediated recruitment of FIP3 to recycling endosomes. (PubMed id 17007872)^{1, 2} Eathiraj S.... Lambright D.G. (J. Mol. Biol. 2006)
The FIP3-Rab11 protein complex regulates recycling endosome targeting to the cleavage furrow during late cytokinesis. (PubMed id 15601896)^{1, 2} Wilson G.M.... Prekeris R. (Mol. Biol. Cell 2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9727	HGNC: 17224	AceView: RAB11FIP3	Ensembl:ENSG00000090565	euGenes: HUgn9727
ECgene: RAB11FIP3	Kegg: 9727	H-InvDB: RAB11FIP3

(According to HUGE)
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HUGE: KIAA0665

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for RAB11FIP3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RAB11FIP3 gene
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Patent Information for RAB11FIP3 gene:
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RAB11FIP3 Gene

RAB11 Family Interacting Protein 3 (Class II)

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RAB11FIP3 Gene

RAB11 Family Interacting Protein 3 (Class II)

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