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Aliases for RAB11FIP3 Gene

Aliases for RAB11FIP3 Gene

  • RAB11 Family Interacting Protein 3 2 3 5
  • Arfophilin-1 2 3 4
  • RAB11 Family Interacting Protein 3 (Class II) 2 3
  • EF Hands-Containing Rab-Interacting Protein 3 4
  • MU-MB-17.148 3 4
  • FIP3-Rab11 3 4
  • Rab11-FIP3 3 4
  • Eferin 3 4
  • Cytoplasmic Adaptor For RAR And TR 3
  • Rab11 Family-Interacting Protein 3 3
  • PAC196A12.1 3
  • KIAA0665 4
  • CART1 3
  • ARFO1 4

External Ids for RAB11FIP3 Gene

Previous GeneCards Identifiers for RAB11FIP3 Gene

  • GC16P000416
  • GC16P000475
  • GC16P000394

Summaries for RAB11FIP3 Gene

Entrez Gene Summary for RAB11FIP3 Gene

  • Proteins of the large Rab GTPase family (see RAB1A; MIM 179508) have regulatory roles in the formation, targeting, and fusion of intracellular transport vesicles. RAB11FIP3 is one of many proteins that interact with and regulate Rab GTPases (Hales et al., 2001 [PubMed 11495908]).[supplied by OMIM, Mar 2008]

GeneCards Summary for RAB11FIP3 Gene

RAB11FIP3 (RAB11 Family Interacting Protein 3) is a Protein Coding gene. Among its related pathways are Cargo trafficking to the periciliary membrane and Arf6 downstream pathway. GO annotations related to this gene include calcium ion binding and Rab GTPase binding. An important paralog of this gene is RAB11FIP4.

UniProtKB/Swiss-Prot for RAB11FIP3 Gene

  • Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an address tag delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. Also required for the structural integrity of the endosomal recycling compartment during interphase. May play a role in breast cancer cell motility by regulating actin cytoskeleton. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25035494).

Gene Wiki entry for RAB11FIP3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB11FIP3 Gene

Genomics for RAB11FIP3 Gene

Regulatory Elements for RAB11FIP3 Gene

Enhancers for RAB11FIP3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G000508 1.3 ENCODE dbSUPER 4.9 +83.4 83446 2.0 FOXA2 MLX ARID4B DMAP1 ZNF48 TCF12 SLC30A9 GLIS2 PAF1 SP3 ENSG00000269482 LOC105371038 CCDC154 ENSG00000262528 PIGQ NHLRC4 PRR35 ENSG00000268836 WASH4P FAM234A
GH16G000513 0.7 dbSUPER 4.8 +88.8 88827 2.4 ZNF639 RING1 THRB ZBTB7A ZNF121 ZNF589 GLIS2 ZNF316 ZBTB33 ZNF600 ENSG00000269482 LOC105371038 CCDC154 ENSG00000262528 PRR35 PIGQ NHLRC4 ENSG00000268836 CAPN15 WASH4P
GH16G000423 1.1 ENCODE 0.7 -0.1 -71 3.9 HNRNPUL1 PKNOX1 CREB3L1 ZFP64 SIN3A ARID4B DMAP1 ZNF2 ZBTB7B YY1 DECR2 NME4 TMEM8A RAB11FIP3 ENSG00000276984
GH16G000428 1 Ensembl ENCODE 0.7 +3.5 3541 1.9 RFX1 HLF BHLHE40 ZIC2 ATF2 ZNF664 ZNF121 GLIS1 ZSCAN5C ZNF629 DECR2 NME4 CAPN15 PRR35 PIGQ NHLRC4 RAB11FIP3 GC16M000427
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RAB11FIP3 on UCSC Golden Path with GeneCards custom track

Genomic Location for RAB11FIP3 Gene

Chromosome:
16
Start:
425,592 bp from pter
End:
523,011 bp from pter
Size:
97,420 bases
Orientation:
Plus strand

Genomic View for RAB11FIP3 Gene

Genes around RAB11FIP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB11FIP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB11FIP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB11FIP3 Gene

Proteins for RAB11FIP3 Gene

  • Protein details for RAB11FIP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75154-RFIP3_HUMAN
    Recommended name:
    Rab11 family-interacting protein 3
    Protein Accession:
    O75154
    Secondary Accessions:
    • B0QYI8
    • B0QYT8
    • B1AHQ0
    • B4DEI7
    • B4DZR6
    • Q4VXV7
    • Q7Z5E9
    • Q9H155
    • Q9H1G0
    • Q9NUI0

    Protein attributes for RAB11FIP3 Gene

    Size:
    756 amino acids
    Molecular mass:
    82440 Da
    Quaternary structure:
    • Homodimer. Forms a complex with Rab11 (RAB11A or RAB11B) and ARF6. Interacts with RAB11A; the interaction is direct. Interacts with RAB11B, RAB25 and RAB11FIP4. Interacts with ARF6; according to PubMed:16148947, it specifically interacts with ARF6 but not ARF5. Interacts with ARF6; according to PubMed:17030804 but not PubMed:16148947. Interacts with RACGAP1/MgcRacGAP; interaction takes place during late stage of cytokinesis and is required for recruitment to the midbody. Interacts with ASAP1 and EXOC7. Interacts with dynein intermediate chain and dynactin (DCTN1) (PubMed:25035494).
    SequenceCaution:
    • Sequence=BAA31640.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG57098.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAQ09358.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAQ09642.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAQ11003.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RAB11FIP3 Gene

    Alternative splice isoforms for RAB11FIP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAB11FIP3 Gene

Post-translational modifications for RAB11FIP3 Gene

  • Phosphorylated at Ser-102 by CDK1 during metaphase, and dephosphorylated as cells enter telophase.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RAB11FIP3 Gene

Domains & Families for RAB11FIP3 Gene

Gene Families for RAB11FIP3 Gene

Protein Domains for RAB11FIP3 Gene

Graphical View of Domain Structure for InterPro Entry

O75154

UniProtKB/Swiss-Prot:

RFIP3_HUMAN :
  • The RBD-FIP domain mediates the interaction with Rab11 (RAB11A or RAB11B).
Domain:
  • The RBD-FIP domain mediates the interaction with Rab11 (RAB11A or RAB11B).
genes like me logo Genes that share domains with RAB11FIP3: view

Function for RAB11FIP3 Gene

Molecular function for RAB11FIP3 Gene

UniProtKB/Swiss-Prot Function:
Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an address tag delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. Also required for the structural integrity of the endosomal recycling compartment during interphase. May play a role in breast cancer cell motility by regulating actin cytoskeleton. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25035494).

Gene Ontology (GO) - Molecular Function for RAB11FIP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 12470645
GO:0017137 Rab GTPase binding NAS 11481332
GO:0030306 ADP-ribosylation factor binding IPI 16148947
GO:0042803 protein homodimerization activity IDA 17030804
genes like me logo Genes that share ontologies with RAB11FIP3: view
genes like me logo Genes that share phenotypes with RAB11FIP3: view

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB11FIP3 Gene

Localization for RAB11FIP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB11FIP3 Gene

Recycling endosome membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cleavage furrow. Midbody. Note=In early mitosis remains diffuse and distributed through the cell. The onset of anaphase sequesters these vesicles to the centrosomes at the opposite poles of the cell. During telophase these vesicles move from the centrosomes, to the furrow, and then to the midbody to aid in abscission (PubMed:15158446, PubMed:15601896, PubMed:18511905). Interaction with Rab11 mediates localization to endosomes (PubMed:11495908). Interaction with ARF6 mediates localization to the midbody (PubMed:16148947). {ECO:0000269 PubMed:11495908, ECO:0000269 PubMed:15601896, ECO:0000269 PubMed:16148947, ECO:0000269 PubMed:18511905}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB11FIP3 gene
Compartment Confidence
extracellular 5
cytoskeleton 5
nucleus 5
cytosol 5
endosome 5
golgi apparatus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RAB11FIP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005768 endosome IEA,IDA 15601896
GO:0005813 centrosome IDA 15601896
GO:0005815 microtubule organizing center IDA --
genes like me logo Genes that share ontologies with RAB11FIP3: view

Pathways & Interactions for RAB11FIP3 Gene

genes like me logo Genes that share pathways with RAB11FIP3: view

Pathways by source for RAB11FIP3 Gene

1 KEGG pathway for RAB11FIP3 Gene

Gene Ontology (GO) - Biological Process for RAB11FIP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000910 cytokinesis IMP 15601896
GO:0006810 transport IEA --
GO:0007049 cell cycle IEA --
GO:0016192 vesicle-mediated transport TAS 16148947
GO:0032456 endocytic recycling IDA 17394487
genes like me logo Genes that share ontologies with RAB11FIP3: view

No data available for SIGNOR curated interactions for RAB11FIP3 Gene

Drugs & Compounds for RAB11FIP3 Gene

No Compound Related Data Available

Transcripts for RAB11FIP3 Gene

Unigene Clusters for RAB11FIP3 Gene

RAB11 family interacting protein 3 (class II):
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB11FIP3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: - - - - -
SP2:
SP3: - - -
SP4: - -
SP5: - - -
SP6: - - - -
SP7: -
SP8: -

Relevant External Links for RAB11FIP3 Gene

GeneLoc Exon Structure for
RAB11FIP3
ECgene alternative splicing isoforms for
RAB11FIP3

Expression for RAB11FIP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAB11FIP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RAB11FIP3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (58.3) and Platelet (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RAB11FIP3 Gene



Protein tissue co-expression partners for RAB11FIP3 Gene

NURSA nuclear receptor signaling pathways regulating expression of RAB11FIP3 Gene:

RAB11FIP3

SOURCE GeneReport for Unigene cluster for RAB11FIP3 Gene:

Hs.531642

Evidence on tissue expression from TISSUES for RAB11FIP3 Gene

  • Nervous system(4.6)
  • Adrenal gland(2.1)
  • Kidney(2)
genes like me logo Genes that share expression patterns with RAB11FIP3: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAB11FIP3 Gene

Orthologs for RAB11FIP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB11FIP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB11FIP3 34 35
  • 99.63 (n)
dog
(Canis familiaris)
Mammalia RAB11FIP3 34 35
  • 87.23 (n)
mouse
(Mus musculus)
Mammalia Rab11fip3 34 16 35
  • 84.48 (n)
rat
(Rattus norvegicus)
Mammalia Rab11fip3 34
  • 84.48 (n)
cow
(Bos Taurus)
Mammalia RAB11FIP3 34 35
  • 83.69 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RAB11FIP3 35
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAB11FIP3 35
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100857269 34
  • 75.92 (n)
RAB11FIP3 35
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAB11FIP3 35
  • 71 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii rab11fip3 35
  • 19 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta nuf 35
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F55C12.1 35
  • 18 (a)
OneToMany
Species where no ortholog for RAB11FIP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RAB11FIP3 Gene

ENSEMBL:
Gene Tree for RAB11FIP3 (if available)
TreeFam:
Gene Tree for RAB11FIP3 (if available)

Paralogs for RAB11FIP3 Gene

Paralogs for RAB11FIP3 Gene

(1) SIMAP similar genes for RAB11FIP3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RAB11FIP3: view

Variants for RAB11FIP3 Gene

Sequence variations from dbSNP and Humsavar for RAB11FIP3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000025470 -- 438,530(+) CCTCA(C/T)GAGTA intron-variant
rs1000040992 -- 438,881(+) GACGG(A/C/G)GTTTC intron-variant
rs1000059005 -- 433,297(+) AAGTA(C/G)TGGGA intron-variant
rs1000088616 -- 515,776(+) GACAC(C/G)GACCG intron-variant
rs1000091388 -- 450,874(+) GCTCA(A/C)CTTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB11FIP3 Gene

Variant ID Type Subtype PubMed ID
dgv1282n106 CNV deletion 24896259
dgv1283n106 CNV deletion 24896259
dgv32n68 CNV loss 17160897
dgv4809n54 CNV loss 21841781
dgv4810n54 CNV loss 21841781
dgv4811n54 CNV loss 21841781
dgv4812n54 CNV gain+loss 21841781
dgv4813n54 CNV loss 21841781
dgv4814n54 CNV gain+loss 21841781
dgv4815n54 CNV loss 21841781
dgv4816n54 CNV loss 21841781
esv1003529 CNV insertion 20482838
esv1053020 CNV insertion 17803354
esv1206343 CNV insertion 17803354
esv1572768 CNV insertion 17803354
esv1621246 CNV insertion 17803354
esv21550 CNV gain 19812545
esv2422427 CNV duplication 17116639
esv24273 CNV gain 19812545
esv2642014 CNV insertion 19546169
esv26517 CNV gain 19812545
esv2658752 CNV deletion 23128226
esv2660167 CNV deletion 23128226
esv2661719 CNV deletion 23128226
esv2668893 CNV deletion 23128226
esv2674251 CNV deletion 23128226
esv2750195 CNV deletion 23290073
esv2750197 CNV deletion 23290073
esv2750198 CNV deletion 23290073
esv2750199 CNV deletion 23290073
esv2750200 CNV deletion 23290073
esv2750201 CNV deletion 23290073
esv3346567 CNV duplication 20981092
esv3434682 CNV duplication 20981092
esv3443243 CNV duplication 20981092
esv3552968 CNV deletion 23714750
esv3552970 CNV deletion 23714750
esv3552971 CNV deletion 23714750
esv3637563 CNV gain 21293372
esv3637574 CNV loss 21293372
esv3637575 CNV loss 21293372
esv3637576 CNV gain 21293372
nsv103435 CNV deletion 16902084
nsv1054426 CNV gain 25217958
nsv1069893 CNV deletion 25765185
nsv1069894 CNV deletion 25765185
nsv1108977 CNV deletion 24896259
nsv1118337 CNV deletion 24896259
nsv1123001 CNV deletion 24896259
nsv1134489 CNV deletion 24896259
nsv1160325 CNV duplication 26073780
nsv1700 CNV insertion 18451855
nsv1701 CNV insertion 18451855
nsv457303 CNV loss 19166990
nsv471063 CNV loss 18288195
nsv471064 CNV gain 18288195
nsv521610 CNV gain 19592680
nsv526903 CNV loss 19592680
nsv528354 CNV loss 19592680
nsv570954 CNV loss 21841781
nsv570956 CNV gain 21841781
nsv570960 CNV gain 21841781
nsv570962 CNV gain+loss 21841781
nsv570968 CNV loss 21841781
nsv570969 CNV loss 21841781
nsv570985 CNV loss 21841781
nsv833113 CNV loss 17160897
nsv833114 CNV gain+loss 17160897
nsv9320 CNV loss 18304495
nsv952898 CNV deletion 24416366
nsv954525 CNV deletion 24416366

Variation tolerance for RAB11FIP3 Gene

Residual Variation Intolerance Score: 41.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.88; 48.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAB11FIP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAB11FIP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB11FIP3 Gene

Disorders for RAB11FIP3 Gene

Relevant External Links for RAB11FIP3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAB11FIP3

No disorders were found for RAB11FIP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB11FIP3 Gene

Publications for RAB11FIP3 Gene

  1. Identification of a novel Rab11/25 binding domain present in eferin and rip proteins. (PMID: 11481332) Prekeris R. … Scheller R.H. (J. Biol. Chem. 2001) 2 3 4 22 64
  2. Rab11-FIP3 is a Rab11-binding protein that regulates breast cancer cell motility by modulating the actin cytoskeleton. (PMID: 19327867) Jing J. … Prekeris R. (Eur. J. Cell Biol. 2009) 3 4 22 64
  3. Rab11-FIP3 localises to a Rab11-positive pericentrosomal compartment during interphase and to the cleavage furrow during cytokinesis. (PMID: 15158446) Horgan C.P. … McCaffrey M.W. (Biochem. Biophys. Res. Commun. 2004) 3 4 22 64
  4. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 2 3 4 64
  5. Sequential Cyk-4 binding to ECT2 and FIP3 regulates cleavage furrow ingression and abscission during cytokinesis. (PMID: 18511905) Simon G.C. … Prekeris R. (EMBO J. 2008) 3 4 64

Products for RAB11FIP3 Gene

Sources for RAB11FIP3 Gene

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