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RAB11FIP2 Gene

protein-coding   GIFtS: 53

GC10M119754
RAB11 family interacting protein 2 (class I)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
KIAA0941 1, 2, 3, 5
NRip11 3
Rab11-FIP2 1, 2, 3
nRip11 1, 2
Descriptions
RAB11 family interacting protein 2 (class I) 2
RAB11-FIP2 long isoform 2
rab11-family interacting protein 2 2
External Ids
HGNC: 291521
Entrez Gene: 228412
UniProtKB: Q7L8043
Ensembl: ENSG000001075607
Search outside databases for aliases for RAB11FIP2 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: RFIP2_HUMAN, Q7L804
Function: A Rab11 effector protein acting in the regulation of the transport of vesicles from the
endosomal recycling compartment (ERC) to the plasma membrane. Also involved in receptor-mediated
endocytosis and membrane trafficking of recycling endosomes, probably originating from
clathrin-coated vesicles. Binds preferentially to phosphatidylinositol 3,4,5-trisphosphate
(PtdInsP3) and phosphatidic acid (PA)

Gene Wiki entry for RAB11FIP2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the RAB11FIP2 gene  

Entrez Gene cytogenetic band: 10q26.11   Ensembl cytogenetic band:  10q26.11   HGNC cytogenetic band: 10q26.12

RAB11FIP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M119754:     (about GC identifiers)

Start:
119,754,419 bp from pter
End:
119,796,104 bp from pter
Size:
41,686 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000010.9  NT_030059.12  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: RFIP2_HUMAN, Q7L804 (See protein sequence)
Recommended Name: Rab11 family-interacting protein 2  
Size: 512 amino acids; 58279 Da
Subunit: Homooligomerizes in a Rab11-independent manner. Forms an heterooligomeric complex with
RAB11FIP4. Interacts with AP2A1, MYO5B, RAB11A, RAB11B, RAB25 and REPS1. Interacts with
RAB11A/RAB11B that has been activated by GTP binding
Subcellular location: Cell membrane; Peripheral membrane protein. Recycling endosome membrane;
Peripheral membrane protein. Note=Translocates with RAB11A from the vesicles of the endocytic
recycling compartment (ERC) to the plasma membrane
PDB structure from and Proteopedia :
2GZD (3D)    2GZH (3D)    
Secondary accessions: A6NEI4 Q9Y2F0

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_055719.1  

    ENSEMBL proteins: 
    ENSP00000358200 ENSP00000347839 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse Abcam for Recombinant Proteins
    Human Recombinant Proteins from Abnova (RAB11FIP2)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    3 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005768 endosome IEA--
    GO:0005886 plasma membrane IEA--
    GO:0055038 recycling endosome membrane IEA--
    About this table

    Antibodies for RAB11FIP2: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for RAB11FIP2

    Assays for RAB11FIP2: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    3 InterPro domains/families:
     IPR018029 C2_membr_targeting
     IPR019018 Rab11-bd_FIP_dom_C
     IPR000008 C2_Ca-dep


       GeneDecks  RAB11FIP2 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q7L804

    ProtoNet protein and cluster: Q7L804

    1 Blocks protein family: IPB000008 C2 domain

    UniProtKB/Swiss-Prot: RFIP2_HUMAN, Q7L804
    Similarity: Contains 1 C2 domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (RAB11FIP2)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014904

                  Applied Biosystems Silencer® siRNAs for RAB11FIP2

                  Sigma-Aldrich siRNA for RAB11FIP2  
                         Sigma-Aldrich shRNA for RAB11FIP2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for RAB11FIP2
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_014904
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_014904
                                     untagged cDNA clone in CMV expression vector: NM_014904 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_014904

    UniProtKB/Swiss-Prot: RFIP2_HUMAN, Q7L804
    Function: A Rab11 effector protein acting in the regulation of the transport of vesicles from the
    endosomal recycling compartment (ERC) to the plasma membrane. Also involved in receptor-mediated
    endocytosis and membrane trafficking of recycling endosomes, probably originating from
    clathrin-coated vesicles. Binds preferentially to phosphatidylinositol 3,4,5-trisphosphate
    (PtdInsP3) and phosphatidic acid (PA)

    1 Gene Ontology (GO) molecular function term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515 protein binding IPI18984164
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


     Gene Network CentralTM Interacting Genes and Proteins Network for  RAB11FIP2 


    5/17 Interacting proteins for RAB11FIP2 (ENSP000003582003 Q7L8041, 2) via UniProtKB, MINT, and/or STRING (see all 17 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    Myo5b Myo5b (xeno)P705691EBI-1049676, EBI-975940
    YWHAGP619812MINT-50832
    RAB11AENSP000002618903STRING (score=.999)
    MYO5BENSP000002850393STRING (score=.996)
    RAB11FIP4ENSP000003128373STRING (score=.972)
    About this table

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015031 protein transport IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for RAB11FIP2

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (RAB11FIP2)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014904

                  Sigma-Aldrich siRNA for RAB11FIP2  
                         Sigma-Aldrich shRNA for RAB11FIP2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_014904  

    REFSEQ mRNAs for RAB11FIP2 gene: 

    NM_014904.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_014904  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_014904
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_014904
                                     untagged cDNA clone in CMV expression vector: NM_014904 

    Additional cDNA sequence: 

    AB023158.1 AY037299.1 BC075073.2 BC075074.2 BX647717.1 DQ013303.1 

    6 DOTS entries:

    DT.315059  DT.75155539  DT.121282766  DT.92011077  DT.92427126  DT.99998005 

    24/108 AceView cDNA sequences (see all 108 ):

    AA293373 AA261804 AA844093 AV708927 BM698885 BM975322 AI554523 BC075074 
    AA353999 AB023158 BC075073 AI192727 AW338894 AY037299 BM464387 AW082403 
    NM_014904 AA491241 BU625912 CB045810 AI126381 AI361050 AI190827 AA371639 

    highest scoring ESTs for RAB11FIP2:

    AB023158 AW138525 AW590338 AY037299 BE783505 BM464387 BX492228 AA034971 AA035283 AA040611 

    Unigene Cluster for RAB11FIP2:

    RAB11 family interacting protein 2 (class I)
    Hs.173656  [show with all ESTs]
    Unigene Representative Sequence: NM_014904


    GeneLoc Exon Structure

    2 Ensembl transcripts including schematic representations:
    ENST00000369199  ENST00000355624  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    RAB11FIP2 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for RAB11FIP2

    1 / 2 / 3

    5 probe-sets matching RAB11FIP2 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    32740_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 AB023158 1.00 1.00 1.00 1

    203884_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_014904 0.60 1.00 0.82 1

    203883_s_at2, 3 U133-A 1 1.00 1.00 -- -- BG249608 0.40 1.00 0.76 1

    203884_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    203883_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  RAB11FIP2 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: AATCAGAATT

    SOURCE GeneReport for Unigene cluster: Hs.173656
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for RAB11FIP2 gene from 5/9 species (see all 9 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    RAB11FIP21   -- RAB11 family interacting protein 2 (class I) 93.82(n)
    95.12(a)
    477834  XM_535026.2  XP_535026.2 
    chimpanzee
    (Pan troglodytes)
    RAB11FIP21   -- RAB11 family interacting protein 2 (class I) 99.67(n)
    99.41(a)
    740554  XM_001152212.1  XP_001152212.1 
    cow
    (Bos taurus)
    RAB11FIP21   -- RAB11 family interacting protein 2 (class I) 91.85(n)
    92.95(a)
    540709  XM_612748.3  XP_612748.2 
    rat
    (Rattus norvegicus)
    Rab11fip21   -- RAB11 family interacting protein 2 (class I) 89.71(n)
    93.36(a)
    308003  XM_217660.4  XP_217660.4 
    mouse
    (Mus musculus)
    Rab11fip21, 5 195
    RAB11 family interacting protein 2 (class I)1, 5 89.39(n)1
    93.08(a)1
    749981  NM_001033172.21  NP_001028344.11 
     AK0155345  AK0438885  (see all 14)
    About this table        Species with no ortholog for RAB11FIP2

    ENSEMBL Gene Tree for RAB11FIP2
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for RAB11FIP2 gene
    RAB11FIP12  RAB11FIP52  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/151 NCBI SNPs in RAB11FIP2 are shown (see all 151 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 92)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 10 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs29281251,2
    C,F,H,O119756371(-) GGAGCG/AATTCT 1 -- ut317Minor allele frequency- A:0.13EU EA WA NA 560
    rs29075991,2
    A,C,F,H119797309(+) ACCTTC/TCCAAG 1 -- ng315Minor allele frequency- T:0.33EU EA WA 1888
    rs111982261,2
    C,F,H119755841(+) TCCTCC/TTGTTG 1 -- ut31 ese312Minor allele frequency- N:0.01EU EA WA NA 1052
    rs37405501,2
    C,F,H119757494(+) TTTGGG/ATTATC 1 -- ut3113Minor allele frequency- A:0.13EA NA EU WA 2528
    rs96337281,2
    F,H119797716(+) CAATGG/TTGGAA 1 -- ng314Minor allele frequency- T:0.09EU EA WA 418
    rs170972391,2
    F,H119754385(+) AACACC/TGCTGT 1 -- ng517Minor allele frequency- T:0.02NA EU EA WA 562
    rs122185061,2
    F,H119756977(+) ATATCG/AGCTTT 1 -- ut31 ese34Minor allele frequency- A:0.01EU EA WA 402
    rs79085531,2
    F,H119758465(+) tctctT/CtGTCC 1 -- ut31 ese3 trp31Minor allele frequency- C:0.07WA 108
    rs111982471,2
    F,H119797250(+) TCTCAA/GTTGGA 1 -- ng317Minor allele frequency- G:0.46EU EA NA 662
    --
    rs29281131,2
    H119796271(-) CCTCCT/CCCACT 1 -- ng31 tfbs32Minor allele frequency- C:0.00EA 178
    About this table

    HapMap Linkage Disequilibrium images for RAB11FIP2 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 608599

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/27 PubMed articles for RAB11FIP2 gene (see all 27 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 22841 HGNC: 29152 AceView: RAB11FIP2 Ensembl:ENSG00000107560 euGenes: HUgn22841
    ECgene: RAB11FIP2 H-InvDB: RAB11FIP2
    (According to HUGE)
    About This Section

    HUGE: KIAA0941
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for RAB11FIP2:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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