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Aliases for RAB11FIP2 Gene

Aliases for RAB11FIP2 Gene

  • RAB11 Family Interacting Protein 2 (Class I) 2 3
  • Rab11-FIP2 3 4
  • NRip11 3 4
  • RAB11-FIP2 Long Isoform 3
  • KIAA0941 4

External Ids for RAB11FIP2 Gene

Previous GeneCards Identifiers for RAB11FIP2 Gene

  • GC10M119754
  • GC10M113392

Summaries for RAB11FIP2 Gene

GeneCards Summary for RAB11FIP2 Gene

RAB11FIP2 (RAB11 Family Interacting Protein 2 (Class I)) is a Protein Coding gene. Among its related pathways are Endocytosis and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include protein homodimerization activity and Rab GTPase binding. An important paralog of this gene is RAB11FIP5.

UniProtKB/Swiss-Prot for RAB11FIP2 Gene

  • A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity.

Gene Wiki entry for RAB11FIP2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB11FIP2 Gene

Genomics for RAB11FIP2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RAB11FIP2 Gene

Chromosome:
10
Start:
118,004,916 bp from pter
End:
118,046,877 bp from pter
Size:
41,962 bases
Orientation:
Minus strand

Genomic View for RAB11FIP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAB11FIP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB11FIP2 Gene

Proteins for RAB11FIP2 Gene

  • Protein details for RAB11FIP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L804-RFIP2_HUMAN
    Recommended name:
    Rab11 family-interacting protein 2
    Protein Accession:
    Q7L804
    Secondary Accessions:
    • A6NEI4
    • Q3I768
    • Q9Y2F0

    Protein attributes for RAB11FIP2 Gene

    Size:
    512 amino acids
    Molecular mass:
    58279 Da
    Quaternary structure:
    • Homooligomerizes in a Rab11-independent manner. Forms a heterooligomeric complex with RAB11FIP4. Interacts with AP2A1, MYO5B, RAB25 and REPS1. Interacts with RAB11A and RAB11B (activated GTP-bound form). Interacts with NPC1L1. Interacts (via NPF motifs) with EHD1 and EHD3.
    SequenceCaution:
    • Sequence=BAA76785.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RAB11FIP2 Gene

    Alternative splice isoforms for RAB11FIP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAB11FIP2 Gene

Proteomics data for RAB11FIP2 Gene at MOPED

Post-translational modifications for RAB11FIP2 Gene

  • Phosphorylation at Ser-227 by MARK2 regulates epithelial cell polarity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB11FIP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RAB11FIP2 Gene

Domains & Families for RAB11FIP2 Gene

Gene Families for RAB11FIP2 Gene

Protein Domains for RAB11FIP2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for RAB11FIP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7L804

UniProtKB/Swiss-Prot:

RFIP2_HUMAN :
  • Contains 1 C2 domain.
Domain:
  • Contains 1 C2 domain.
  • Contains 1 FIP-RBD domain.
genes like me logo Genes that share domains with RAB11FIP2: view

Function for RAB11FIP2 Gene

Molecular function for RAB11FIP2 Gene

UniProtKB/Swiss-Prot Function:
A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity.

Gene Ontology (GO) - Molecular Function for RAB11FIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12470645
GO:0017137 Rab GTPase binding IBA --
GO:0019901 protein kinase binding IPI 16775013
GO:0042803 protein homodimerization activity IPI 16905101
genes like me logo Genes that share ontologies with RAB11FIP2: view
genes like me logo Genes that share phenotypes with RAB11FIP2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAB11FIP2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB11FIP2 Gene

Localization for RAB11FIP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB11FIP2 Gene

Cell membrane; Peripheral membrane protein. Recycling endosome membrane; Peripheral membrane protein. Note=Translocates with RAB11A from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB11FIP2 Gene COMPARTMENTS Subcellular localization image for RAB11FIP2 gene
Compartment Confidence
endosome 5
plasma membrane 5
nucleus 4

Gene Ontology (GO) - Cellular Components for RAB11FIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IBA --
GO:0005768 endosome IDA 16905101
GO:0005886 plasma membrane IEA --
GO:0030659 cytoplasmic vesicle membrane TAS --
genes like me logo Genes that share ontologies with RAB11FIP2: view

Pathways & Interactions for RAB11FIP2 Gene

genes like me logo Genes that share pathways with RAB11FIP2: view

SIGNOR curated interactions for RAB11FIP2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for RAB11FIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003091 renal water homeostasis TAS --
GO:0006833 water transport TAS --
GO:0030010 establishment of cell polarity IMP 16775013
GO:0035773 insulin secretion involved in cellular response to glucose stimulus ISS --
GO:0045055 regulated secretory pathway ISS --
genes like me logo Genes that share ontologies with RAB11FIP2: view

Drugs & Compounds for RAB11FIP2 Gene

(1) Drugs for RAB11FIP2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(12) Additional Compounds for RAB11FIP2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PA(16:0/16:0)
  • 1,2-Di-O-palmitoyl-3-sn-glyceryl-O-phosphorate
  • 1,2-Di-O-palmitoyl-3-sn-glyceryl-O-phosphoric acid
  • 1,2-Dihexadecanoyl-rac-phosphatidic acid
  • 1,2-Dipalmitoyl-3-sn-phosphatidate
  • 1,2-Dipalmitoyl-3-sn-phosphatidic acid
7091-44-3
PA(16:0/18:1(11Z))
  • 1-Hexadecanoyl-2-(11Z-octadecenoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-vaccenoyl-sn-glycero-3-phosphate
  • PA(16:0/18:1)
  • PA(16:0/18:1n7)
  • PA(16:0/18:1w7)
PA(16:0/18:1(9Z))
  • 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphate
  • PA(16:0/18:1)
  • PA(16:0/18:1n9)
  • PA(16:0/18:1w9)
PA(16:0/18:2(9Z,12Z))
  • 1-Hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-linoleoyl-sn-glycero-3-phosphate
  • PA(16:0/18:2)
  • PA(16:0/18:2n6)
  • PA(16:0/18:2w6)
PA(16:0e/18:0)
  • 2-Octadecanoyl-1-hexadecyl-sn-glycero-3-phosphate
  • PA(O-16:0/18:0)
genes like me logo Genes that share compounds with RAB11FIP2: view

Transcripts for RAB11FIP2 Gene

Unigene Clusters for RAB11FIP2 Gene

RAB11 family interacting protein 2 (class I):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAB11FIP2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB11FIP2 Gene

No ASD Table

Relevant External Links for RAB11FIP2 Gene

GeneLoc Exon Structure for
RAB11FIP2
ECgene alternative splicing isoforms for
RAB11FIP2

Expression for RAB11FIP2 Gene

mRNA expression in normal human tissues for RAB11FIP2 Gene

Protein differential expression in normal tissues from HIPED for RAB11FIP2 Gene

This gene is overexpressed in Liver (57.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB11FIP2 Gene



SOURCE GeneReport for Unigene cluster for RAB11FIP2 Gene Hs.173656

genes like me logo Genes that share expression patterns with RAB11FIP2: view

Protein tissue co-expression partners for RAB11FIP2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RAB11FIP2 Gene

Orthologs for RAB11FIP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB11FIP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RAB11FIP2 35
  • 91.85 (n)
  • 92.95 (a)
RAB11FIP2 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAB11FIP2 35
  • 93.75 (n)
  • 95.12 (a)
RAB11FIP2 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rab11fip2 35
  • 89.53 (n)
  • 93.48 (a)
Rab11fip2 16
Rab11fip2 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RAB11FIP2 35
  • 99.61 (n)
  • 99.41 (a)
RAB11FIP2 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rab11fip2 35
  • 89.71 (n)
  • 93.36 (a)
oppossum
(Monodelphis domestica)
Mammalia RAB11FIP2 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAB11FIP2 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAB11FIP2 35
  • 80.07 (n)
  • 81.96 (a)
RAB11FIP2 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAB11FIP2 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rab11fip2 35
  • 61.17 (n)
  • 63.54 (a)
Str.16364 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.33937 35
zebrafish
(Danio rerio)
Actinopterygii Dr.16541 35
LOC100334729 35
  • 60.55 (n)
  • 61.73 (a)
BX842696.1 36
  • 56 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Rip11 36
  • 11 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8553 36
  • 22 (a)
OneToMany
Species with no ortholog for RAB11FIP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAB11FIP2 Gene

ENSEMBL:
Gene Tree for RAB11FIP2 (if available)
TreeFam:
Gene Tree for RAB11FIP2 (if available)

Paralogs for RAB11FIP2 Gene

Paralogs for RAB11FIP2 Gene

(2) SIMAP similar genes for RAB11FIP2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RAB11FIP2: view

Variants for RAB11FIP2 Gene

Sequence variations from dbSNP and Humsavar for RAB11FIP2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1016112 -- 118,028,672(-) ACACT(A/G)CTTTT intron-variant
rs1539618 -- 118,028,365(+) CATGT(C/G)AAAGA intron-variant
rs1539619 -- 118,029,138(+) AAATG(C/T)TACAT intron-variant
rs1990325 -- 118,041,707(+) TGCCA(A/G)GAGAA intron-variant
rs2000290 -- 118,036,144(+) ATAAT(A/T)TACAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB11FIP2 Gene

Variant ID Type Subtype PubMed ID
nsv832005 CNV Gain 17160897
nsv516870 CNV Loss 19592680
nsv825580 CNV Gain 20364138
nsv7566 CNV Loss 18451855
nsv528184 CNV Loss 19592680
nsv7567 CNV Insertion 18451855

Variation tolerance for RAB11FIP2 Gene

Residual Variation Intolerance Score: 20.47% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.49; 64.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAB11FIP2 Gene

HapMap Linkage Disequilibrium report
RAB11FIP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB11FIP2 Gene

Disorders for RAB11FIP2 Gene

Relevant External Links for RAB11FIP2

Genetic Association Database (GAD)
RAB11FIP2
Human Genome Epidemiology (HuGE) Navigator
RAB11FIP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAB11FIP2
genes like me logo Genes that share disorders with RAB11FIP2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB11FIP2 Gene

Publications for RAB11FIP2 Gene

  1. Disorder and structure in the Rab11 binding domain of Rab11 family interacting protein 2. (PMID: 19119858) Wei J. … Baleja J.D. (Biochemistry 2009) 23 67
  2. Requirement of myosin Vb.Rab11a.Rab11-FIP2 complex in cholesterol- regulated translocation of NPC1L1 to the cell surface. (PMID: 19542231) Chu B.-B. … Song B.-L. (J. Biol. Chem. 2009) 23 67
  3. Rab11-FIP2 regulates differentiable steps in transcytosis. (PMID: 17626244) Ducharme N.A. … Goldenring J.R. (Am. J. Physiol., Cell Physiol. 2007) 23 67
  4. Molecular dissection of Rab11 binding from coiled-coil formation in the Rab11-FIP2 C-terminal domain. (PMID: 16734419) Wei J. … Baleja J.D. (Biochemistry 2006) 23 67
  5. Crystal structure of rab11 in complex with rab11 family interacting protein 2. (PMID: 16905101) Jagoe W.N. … Khan A.R. (Structure 2006) 23 67

Products for RAB11FIP2 Gene

Sources for RAB11FIP2 Gene

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