Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



RAB11FIP2 Gene

protein-coding   GIFtS: 60
GCID: GC10M119754

RAB11 Family Interacting Protein 2 (Class I)

  Search for RAB11FIP2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
RAB11 Family Interacting Protein 2 (Class I)1 2     Rab11 Family-Interacting Protein 22
Rab11-FIP22 3     RAB11-FIP2 Long Isoform2
KIAA09413 5     NRip113
nRip112     

External Ids:    HGNC: 291521   Entrez Gene: 228412   Ensembl: ENSG000001075607   OMIM: 6085995   UniProtKB: Q7L8043   

Export aliases for RAB11FIP2 gene to outside databases

Previous GC identifer: GC10M113392


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for RAB11FIP2 Gene:
RAB11FIP2 (RAB11 family interacting protein 2 (class I)) is a protein-coding gene. GO annotations related to this gene include protein kinase binding and protein homodimerization activity. An important paralog of this gene is RAB11FIP1.

UniProtKB/Swiss-Prot: RFIP2_HUMAN, Q7L804
Function: A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and
phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling
compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in
receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from
clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma
membrane. Also acts as a regulator of cell polarity

Gene Wiki entry for RAB11FIP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RAB11FIP2 gene promoter:
         USF1   AP-2alpha isoform 3   AP-2alpha isoform 2   POU3F2   GATA-1   USF-1   Hand1   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRAB11FIP2 promoter sequence
   Search Chromatin IP Primers for RAB11FIP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RAB11FIP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26.11   Ensembl cytogenetic band:  10q26.11   HGNC cytogenetic band: 10q26.12

RAB11FIP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAB11FIP2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M119754:  view genomic region     (about GC identifiers)

Start:
119,764,427 bp from pter      End:
119,806,114 bp from pter
Size:
41,688 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RFIP2_HUMAN, Q7L804 (See protein sequence)
Recommended Name: Rab11 family-interacting protein 2  
Size: 512 amino acids; 58279 Da
Subunit: Homooligomerizes in a Rab11-independent manner. Forms a heterooligomeric complex with RAB11FIP4.
Interacts with AP2A1, MYO5B, RAB25 and REPS1. Interacts with RAB11A and RAB11B (activated GTP-bound form).
Interacts with NPC1L1
Sequence caution: Sequence=BAA76785.2; Type=Erroneous initiation;
5 PDB 3D structures from and Proteopedia for RAB11FIP2:
2GZD (3D)        2GZH (3D)        2K6S (3D)        3TSO (3D)        4C4P (3D)    
Secondary accessions: A6NEI4 Q9Y2F0

Explore the universe of human proteins at neXtProt for RAB11FIP2: NX_Q7L804

Explore proteomics data for RAB11FIP2 at MOPED

Post-translational modifications: 

  • Phosphorylation at Ser-227 by MARK2 regulates epithelial cell polarity1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RAB11FIP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055719.1  
    ENSEMBL proteins: 
     ENSP00000347839   ENSP00000358200  
    Reactome Protein details: Q7L804

    RAB11FIP2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for RAB11FIP2
    OriGene Protein Over-expression Lysate for RAB11FIP2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for RAB11FIP2
    GenScript Custom Purified and Recombinant Proteins Services for RAB11FIP2
    Novus Biologicals RAB11FIP2 Protein
    Novus Biologicals RAB11FIP2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RAB11FIP2

     
    Search eBioscience for Proteins for RAB11FIP2 

    RAB11FIP2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for RAB11FIP2
    OriGene Custom Antibody Services for RAB11FIP2
    Novus Biologicals RAB11FIP2 Antibodies
    Abcam antibodies for RAB11FIP2
    Cloud-Clone Corp. Antibodies for RAB11FIP2
    ThermoFisher Antibody for RAB11FIP2
    LSBio Antibodies in human, mouse, rat for RAB11FIP2

    RAB11FIP2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RAB11FIP2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RAB11FIP2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RAB11FIP2
    Cloud-Clone Corp. CLIAs for RAB11FIP2
    Search eBioscience for ELISAs for RAB11FIP2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR019018 Rab-bd_FIP-RBD
     IPR000008 C2_dom

    Graphical View of Domain Structure for InterPro Entry Q7L804

    ProtoNet protein and cluster: Q7L804

    1 Blocks protein domain: IPB000008 C2 domain

    UniProtKB/Swiss-Prot: RFIP2_HUMAN, Q7L804
    Similarity: Contains 1 C2 domain
    Similarity: Contains 1 FIP-RBD domain


    Find genes that share domains with RAB11FIP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RFIP2_HUMAN, Q7L804
    Function: A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and
    phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling
    compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in
    receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from
    clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma
    membrane. Also acts as a regulator of cell polarity

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12470645
    GO:0019901protein kinase binding IPI16775013
    GO:0042803protein homodimerization activity IPI16905101
         
    Find genes that share ontologies with RAB11FIP2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for RAB11FIP2:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RAB11FIP2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RAB11FIP2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RAB11FIP2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RAB11FIP2

    miRNA
    Products:
        
    miRTarBase miRNAs that target RAB11FIP2:
    hsa-mir-215-5p (MIRT024655), hsa-mir-192-5p (MIRT026543), hsa-mir-155-5p (MIRT020855), hsa-mir-1 (MIRT002812), hsa-mir-21-5p (MIRT030937)

    Block miRNA regulation of human, mouse, rat RAB11FIP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RAB11FIP2 (see all 51):
    hsa-miR-411* hsa-miR-379* hsa-miR-429 hsa-miR-513a-5p hsa-miR-15a hsa-miR-1184 hsa-miR-424 hsa-miR-155
    SwitchGear 3'UTR luciferase reporter plasmidRAB11FIP2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RAB11FIP2
    Predesigned siRNA for gene silencing in human, mouse, rat RAB11FIP2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RAB11FIP2

    Clone
    Products:
         
    OriGene clones in human, mouse for RAB11FIP2 (see all 7)
    OriGene ORF clones in mouse, rat for RAB11FIP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RAB11FIP2 (NM_014904)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAB11FIP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB11FIP2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RAB11FIP2
    Browse ESI BIO Cell Lines and PureStem Progenitors for RAB11FIP2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB11FIP2

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12031) for RAB11FIP2 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    RFIP2_HUMAN, Q7L804: Cell membrane; Peripheral membrane protein. Recycling endosome membrane; Peripheral membrane
    protein. Note=Translocates with RAB11A from the vesicles of the endocytic recycling compartment (ERC) to the
    plasma membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    plasma membrane5
    nucleus4
    cytosol3

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005768endosome IDA16905101
    GO:0005886plasma membrane IEA--
    GO:0030659cytoplasmic vesicle membrane TAS--

    Find genes that share ontologies with RAB11FIP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for RAB11FIP2 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Regulation of Water Balance by Renal Aquaporins
    Regulation of Water Balance by Renal Aquaporins0.85
    Aquaporin-mediated transport0.85
    2Clathrin dependent protein traffic
    Transport Clathrin coated vesicle cycle0.66
    3Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Transmembrane transport of small molecules0.47
    4Regulation of CFTR activity norm and CF
    wtCFTR and deltaF508 traffic Membrane expression norm and CF 0.38
    5Endocytosis
    Endocytosis


    Find genes that share SuperPaths with RAB11FIP2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 GeneGo (Thomson Reuters) Pathways for RAB11FIP2
        Cholesterol and Sphingolipids transport / Recycling to plasma membrane in lung (normal and CF)
    wtCFTR and deltaF508 traffic / Membrane expression (norm and CF)
    Transport Clathrin-coated vesicle cycle

    1 Reactome Pathway for RAB11FIP2
        Regulation of water balance by renal Aquaporins


    1 Kegg Pathway  (Kegg details for RAB11FIP2):
        Endocytosis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RAB11FIP2
    Interactions:

        GeneGlobe Interaction Network for RAB11FIP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for RAB11FIP2 (Q7L8041, 2, 3 ENSP000003478394) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAGP619812, 3, ENSP000003063304MINT-50832 I2D: score=4 STRING: ENSP00000306330
    RAB11AP624911, 3, ENSP000002618904EBI-1049676,EBI-745098 I2D: score=3 STRING: ENSP00000261890
    CXCR2P250253, ENSP000003196354I2D: score=3 STRING: ENSP00000319635
    MYO5BQ9ULV03, ENSP000002850394I2D: score=2 STRING: ENSP00000285039
    RAB11BQ159073, ENSP000003335474I2D: score=2 STRING: ENSP00000333547
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006833water transport TAS--
    GO:0015031protein transport IEA--
    GO:0030010establishment of cell polarity IMP16775013
    GO:0035773insulin secretion involved in cellular response to glucose stimulus ISS--
    GO:0045055regulated secretory pathway ISS--

    Find genes that share ontologies with RAB11FIP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RAB11FIP2 (RFIP2)

    Selected HMDB Compounds for RAB11FIP2 (see all 13)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    PA(16:0/16:0)Dipalmitoylphosphatidic acid (see all 25)7091-44-3--
    PA(16:0/18:1(11Z))PA(16:0/18:1n7) (see all 10)----
    PA(16:0/18:1(9Z))PA(16:0/18:1n9) (see all 10)----
    PA(16:0/18:2(9Z,12Z))PA(34:2) (see all 10)----
    PA(16:0e/18:0)2-octadecanoyl-1-hexadecyl-sn-glycero-3-phosphate ;PA(o-16:0/18:0) ----
    PA(18:0/18:2(9Z,12Z))PA(36:2) (see all 10)----
    PA(18:1(11Z)/18:1(11Z))PA(36:2) (see all 10)----
    PA(18:1(11Z)/18:1(9Z))PA(36:2) (see all 10)----
    PA(18:1(9Z)/18:1(11Z))PA(36:2) (see all 10)----



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for RAB11FIP2 gene: 
    NM_014904.2  

    Unigene Cluster for RAB11FIP2:

    RAB11 family interacting protein 2 (class I)
    Hs.173656  [show with all ESTs]
    Unigene Representative Sequence: NM_014904
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000355624(uc001ldj.2 uc009xyz.2) ENST00000476207 ENST00000483413
    ENST00000369199
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RAB11FIP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RAB11FIP2 (see all 51):
    hsa-miR-411* hsa-miR-379* hsa-miR-429 hsa-miR-513a-5p hsa-miR-15a hsa-miR-1184 hsa-miR-424 hsa-miR-155
    SwitchGear 3'UTR luciferase reporter plasmidRAB11FIP2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RAB11FIP2
    Predesigned siRNA for gene silencing in human, mouse, rat RAB11FIP2
    Clone
    Products:
         
    OriGene clones in human, mouse for RAB11FIP2 (see all 7)
    OriGene ORF clones in mouse, rat for RAB11FIP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RAB11FIP2 (NM_014904)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAB11FIP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB11FIP2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for RAB11FIP2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RAB11FIP2
      QuantiTect SYBR Green Assays in human, mouse, rat RAB11FIP2
      QuantiFast Probe-based Assays in human, mouse, rat RAB11FIP2
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12031) for RAB11FIP2 

    Additional mRNA sequence: 

    AB023158.1 AY037299.1 BC075073.2 BC075074.2 BX647717.1 DQ013303.1 

    5 DOTS entries:

    DT.315059  DT.75155539  DT.121282766  DT.92011077  DT.99998005 

    Selected AceView cDNA sequences (see all 108):

    AA491242 NM_014904 AL700324 AB023158 AW086181 AA780510 BC075073 AY037299 
    AA491241 AW241955 AA353999 AI126381 AA603053 BM975322 AA844093 BM698885 
    AI635901 AI192727 AI422797 AA261804 AI418215 AA730180 AI378735 AW082403 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    RAB11FIP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATCAGAATT
    RAB11FIP2 Expression
    About this image

    RAB11FIP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RAB11FIP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.173656
        Custom PCR Arrays for RAB11FIP2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for RAB11FIP2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RAB11FIP2
    QuantiTect SYBR Green Assays in human, mouse, rat RAB11FIP2
    QuantiFast Probe-based Assays in human, mouse, rat RAB11FIP2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB11FIP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for RAB11FIP2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rab11fip21 , 5 RAB11 family interacting protein 2 (class I)1, 5 89.53(n)1
    93.48(a)1
      19 (56.28 cM)5
    749981  NM_001033172.31  NP_001028344.21 
     599028845 
    chicken
    (Gallus gallus)
    Aves RAB11FIP21 RAB11 family interacting protein 2 (class I) 80.07(n)
    81.96(a)
      423924  XM_421784.4  XP_421784.1 
    lizard
    (Anolis carolinensis)
    Reptilia RAB11FIP26
    RAB11 family interacting protein 2 (class I)
    78(a)
    1 ↔ 1
    GL343206.1(649407-679804)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.339372 Xenopus laevis transcribed sequence with moderate similarity more 72.56(n)    CD255310.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.165412 Transcribed sequence with moderate similarity to protein more 71.57(n)    BI709917.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rip116
    Rab11 interacting protein
    11(a)
    1 → many
    X(18529675-18541596)


    ENSEMBL Gene Tree for RAB11FIP2 (if available)
    TreeFam Gene Tree for RAB11FIP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for RAB11FIP2 gene
    RAB11FIP12  RAB11FIP52  
    2 SIMAP similar genes for RAB11FIP2 using alignment to 2 protein entries:     RFIP2_HUMAN (see all proteins):
    GAF1    RAB11FIP1

    Find genes that share paralogs with RAB11FIP2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for RAB11FIP2 (see all 722)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1415007601,2
    C,Funtested1119774577(+) TTACCA/G/TGGATT 2 Q P mis12NA EU 5861
    rs1871312691,2
    --119764071(+) TGTTGC/TGAGAA 1 -- int10--------
    rs1407394711,2
    C--119764136(+) TACTC-/AAAATA 1 -- int10--------
    rs1911642561,2
    --119764157(+) TAAATC/TGTAAG 1 -- int10--------
    rs1815050831,2
    --119764335(+) AGAGGC/TATCCT 1 -- int10--------
    rs1858843511,2
    --119764367(+) GAGGAC/TTCATA 1 -- int10--------
    rs1899000311,2
    --119764370(+) GACTCA/GTATAT 1 -- int10--------
    rs170972391,2
    C,F,H--119764395(+) AACACC/TGCTGT 1 -- int117Minor allele frequency- T:0.02NA NS EA WA 2110
    rs1832738361,2
    --119764396(+) ACACCA/GCTGTA 1 -- int10--------
    rs1444704841,2
    --119764606(+) GATAAA/GTGTTA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for RAB11FIP2 (119764427 - 119806114 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for RAB11FIP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv7567CNV Insertion18451855
    nsv528184CNV Loss19592680
    nsv516870CNV Loss19592680
    nsv7566CNV Loss18451855
    nsv825580CNV Gain20364138
    nsv832005CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RAB11FIP2
    DNA2.0 Custom Variant and Variant Library Synthesis for RAB11FIP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 608599    OMIM disorders: --


    Find genes that share disorders with RAB11FIP2           About GenesLikeMe

    Genetic Association Database (GAD): RAB11FIP2
    Human Genome Epidemiology (HuGE) Navigator: RAB11FIP2 (1 document)

    Export disorders for RAB11FIP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for RAB11FIP2 gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with RAB11FIP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Rab11-FIP2 functions in transferrin recycling and associates with endosomal membranes via its COOH-terminal domain. (PubMed id 11994279)1, 2, 3 Lindsay A.J. and McCaffrey M.W. (J. Biol. Chem. 2002)
    2. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1999)
    3. Requirement of myosin Vb.Rab11a.Rab11-FIP2 complex in cholesterol- regulated translocation of NPC1L1 to the cell surface. (PubMed id 19542231)1, 2, 9 Chu B.-B....Song B.-L. (J. Biol. Chem. 2009)
    4. Crystal structure of rab11 in complex with rab11 family interacting protein 2. (PubMed id 16905101)1, 2, 9 Jagoe W.N....Khan A.R. (Structure 2006)
    5. The C2 domains of the class I Rab11 family of interacting proteins target recycling vesicles to the plasma membrane. (PubMed id 15304524)1, 2, 9 Lindsay A.J. and McCaffrey M.W. (J. Cell Sci. 2004)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. MARK2/EMK1/Par-1Balpha phosphorylation of Rab11-family interacting protein 2 is necessary for the timely establishment of polarity in Madin-Darby canine kidney cells. (PubMed id 16775013)1, 2 Ducharme N.A.... Goldenring J.R. (Mol. Biol. Cell 2006)
    8. Molecular characterization of Rab11 interactions with members of the family of Rab11-interacting proteins. (PubMed id 15173169)1, 2 Junutula J.R....Prekeris R. (J. Biol. Chem. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. The novel Rab11-FIP/Rip/RCP family of proteins displays extensive homo- and hetero-interacting abilities. (PubMed id 11944901)1, 2 Wallace D.M.... McCaffrey M.W. (Biochem. Biophys. Res. Commun. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 22841 HGNC: 29152 AceView: RAB11FIP2 Ensembl:ENSG00000107560 euGenes: HUgn22841
    ECgene: RAB11FIP2 Kegg: 22841 H-InvDB: RAB11FIP2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA0941

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for RAB11FIP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for RAB11FIP2 gene:
    Search GeneIP for patents involving RAB11FIP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for RAB11FIP2   OriGene RNAi products in human, mouse, rat for RAB11FIP2  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for RAB11FIP2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for RAB11FIP2  
     OriGene qSTAR qPCR primer pairs in human, mouse for RAB11FIP2   OriGene Purified Protein for RAB11FIP2  
     OriGene ORF clones in mouse, rat for RAB11FIP2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RAB11FIP2   OriGene Custom Protein Services for RAB11FIP2  

     
     
     Block miRNA regulation of human, mouse, rat RAB11FIP2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing RAB11FIP2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RAB11FIP2 Predesigned siRNA for gene silencing in human, mouse, rat RAB11FIP2
     QuantiFast Probe-based Assays in human, mouse, rat RAB11FIP2 QuantiTect SYBR Green Assays in human, mouse, rat RAB11FIP2
     Custom PCR Arrays for RAB11FIP2 Search Chromatin IP Primers for RAB11FIP2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RAB11FIP2  GeneGlobe Interaction Network for RAB11FIP2
     Regulatory tfbs in RAB11FIP2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for RAB11FIP2 GenScript cDNA clones with any tag delivered in your preferred vector for RAB11FIP2
     GenScript Custom Assay Services for RAB11FIP2 GenScript Custom overexpressing Cell Line Services for RAB11FIP2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for RAB11FIP2 (RFIP2)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     RAB11FIP2 antibodies
     RAB11FIP2 proteins
     RAB11FIP2 lysates
     Antibodies for RAB11FIP2
     See all of Abcam's Antibodies, Kits and Proteins for RAB11FIP2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for RAB11FIP2
     Antibodies for RAB11FIP2
     ELISAs for RAB11FIP2
     CLIAs for RAB11FIP2



     Browse ESI BIO Cell Lines and PureStem Progenitors for RAB11FIP2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB11FIP2
     SwitchGear 3'UTR luciferase reporter plasmids for RAB11FIP2
     SwitchGear Promoter luciferase reporter plasmids for RAB11FIP2
     ThermoFisher Antibody for RAB11FIP2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB11FIP2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RAB11FIP2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RAB11FIP2
     LSBio Antibodies in human, mouse, rat for RAB11FIP2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for RAB11FIP2
      Search eBioscience for proteins for RAB11FIP2
      Search eBioscience for elisas for RAB11FIP2
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RAB11FIP2 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4