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Aliases & Descriptions for RAB11FIP2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| KIAA0941 1, 2, 3, 5 | | NRip11 3 | | Rab11-FIP2 1, 2, 3 | | nRip11 1, 2 |
| | | Descriptions |
|---|
| RAB11 family interacting protein 2 (class I) 2 | | RAB11-FIP2 long isoform 2 | | rab11-family interacting protein 2 2 |
|
| | Search outside databases for aliases for RAB11FIP2 gene |
Summaries for RAB11FIP2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: RFIP2_HUMAN, Q7L804Function: A Rab11 effector protein acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Binds preferentially to phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA)Gene Wiki entry for RAB11FIP2 |
Genomic Location for RAB11FIP2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the RAB11FIP2 gene 
Entrez Gene cytogenetic band: 10q26.11 Ensembl cytogenetic band: 10q26.11 HGNC cytogenetic band: 10q26.12RAB11FIP2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M119754:
(about GC identifiers)
Start:
|
119,754,419 bp from pter |
End:
|
119,796,104 bp from pter |
Size:
|
41,686 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000010.9 NT_030059.12
| Proteins for RAB11FIP2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: RFIP2_HUMAN, Q7L804 (See
protein sequence)Recommended Name: Rab11 family-interacting protein 2 Size: 512 amino acids; 58279 Da
Subunit: Homooligomerizes in a Rab11-independent manner. Forms an heterooligomeric complex with RAB11FIP4. Interacts with AP2A1, MYO5B, RAB11A, RAB11B, RAB25 and REPS1. Interacts with RAB11A/RAB11B that has been activated by GTP binding
Subcellular location: Cell membrane; Peripheral membrane protein. Recycling endosome membrane; Peripheral membrane protein. Note=Translocates with RAB11A from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane
PDB structure from and Proteopedia :2GZD (3D)
 2GZH (3D)
 
Secondary accessions: A6NEI4 Q9Y2F0Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_055719.1
ENSEMBL proteins: ENSP00000358200 ENSP00000347839
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for RAB11FIP2: Assays for RAB11FIP2: | Protein
Domains/ Families for RAB11FIP2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q7L804
ProtoNet protein and cluster: Q7L804 1 Blocks protein family: IPB000008 C2 domain
UniProtKB/Swiss-Prot: RFIP2_HUMAN, Q7L804Similarity: Contains 1 C2 domain | Gene Function for RAB11FIP2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014904
Applied Biosystems Silencer® siRNAs for RAB11FIP2
Sigma-Aldrich siRNA for RAB11FIP2  Sigma-Aldrich shRNA for RAB11FIP2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_014904                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_014904                                  untagged cDNA clone in CMV expression vector: NM_014904 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_014904
UniProtKB/Swiss-Prot: RFIP2_HUMAN, Q7L804Function: A Rab11 effector protein acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Binds preferentially to phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA)1 Gene Ontology (GO) molecular function term (links to tree view): About this table | Pathways & Interactions for RAB11FIP2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for RAB11FIP2 
5/17 Interacting proteins for RAB11FIP2 (ENSP000003582003 Q7L8041, 2) via UniProtKB, MINT, and/or STRING (see all 17
)About this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0015031 | protein transport |
IEA | -- | About this table
|
Drugs & Compounds for RAB11FIP2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for RAB11FIP2
|
Transcripts for RAB11FIP2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014904
Sigma-Aldrich siRNA for RAB11FIP2  Sigma-Aldrich shRNA for RAB11FIP2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_014904 REFSEQ mRNAs for RAB11FIP2 gene: NM_014904.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_014904               OriGene GFP tagged cDNA clone in CMV expression vector: NM_014904                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_014904                                  untagged cDNA clone in CMV expression vector: NM_014904  Additional cDNA sequence: AB023158.1 AY037299.1 BC075073.2 BC075074.2 BX647717.1 DQ013303.1 6 DOTS entries: DT.315059 DT.75155539 DT.121282766 DT.92011077 DT.92427126 DT.99998005 24/108 AceView cDNA sequences (see all 108
):AA293373 AA261804 AA844093 AV708927 BM698885 BM975322 AI554523 BC075074 AA353999 AB023158 BC075073 AI192727 AW338894 AY037299 BM464387 AW082403 NM_014904 AA491241 BU625912 CB045810 AI126381 AI361050 AI190827 AA371639
highest scoring ESTs for RAB11FIP2:AB023158 AW138525 AW590338 AY037299 BE783505 BM464387 BX492228 AA034971 AA035283 AA040611 Unigene Cluster for RAB11FIP2: RAB11 family interacting protein 2 (class I) Hs.173656 [show with all ESTs]Unigene Representative Sequence: NM_014904
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations: ENST00000369199
ENST00000355624
|
Expression for RAB11FIP2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| RAB11FIP2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for RAB11FIP2
1 / 2 / 3 5 probe-sets matching RAB11FIP2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: AATCAGAATT
SOURCE GeneReport for Unigene cluster: Hs.173656
|
Orthologs for RAB11FIP2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for RAB11FIP2 gene from 5/9 species (see all 9
)
About this table Species with no ortholog for RAB11FIP2
ENSEMBL Gene Tree for RAB11FIP2 | Paralogs for RAB11FIP2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for RAB11FIP2 gene
- RAB11FIP12 RAB11FIP52
|
SNPs/Variants for RAB11FIP2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for RAB11FIP2 (up to first 250kb)
|
Disorders & Mutations for RAB11FIP2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 608599
|
Medical News for RAB11FIP2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for RAB11FIP2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/27 PubMed articles for RAB11FIP2 gene (see all 27
):- Rab11-FIP2 functions in transferrin recycling and associates with endosomal membranes via its COOH-terminal domain. (PubMed id 11994279)2, 3, 4 Lindsay A.J. and McCaffrey M.W. (2002)
- Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)2, 3, 4 Nagase T....Ohara O. (1999)
- The C2 domains of the class I Rab11 family of interacting proteins target recycling vesicles to the plasma membrane. (PubMed id 15304524)1, 3, 4 Lindsay A.J. and McCaffrey M.W. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Molecular characterization of Rab11 interactions with members of the family of Rab11-interacting proteins. (PubMed id 15173169)3, 4 Junutula J.R....Prekeris R. (2004)
- The novel Rab11-FIP/Rip/RCP family of proteins displays extensive homo- and hetero-interacting abilities. (PubMed id 11944901)3, 4 Wallace D.M.... McCaffrey M.W. (2002)
- Rab11-FIP2, an adaptor protein connecting cellular components involved in internalization and recycling of epidermal growth factor receptors. (PubMed id 12364336)3, 4 Cullis D.N.... Feig L.A. (2002)
- Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and its overexpression condenses the Rab11 positive compartment in HeLa cells. (PubMed id 12470645)3, 4 Wallace D.M.... McCaffrey M.W. (2002)
- Identification and characterization of a family of Rab11-interacting proteins. (PubMed id 11495908)3, 4 Hales C.M....Goldenring J.R. (2001)
- Rab11-family interacting protein 2 and myosin Vb are required for CXCR2 recycling and receptor-mediated chemotaxis. (PubMed id 15004234)1, 3 Fan G.H....Richmond A. (2004)
|
Search for RAB11FIP2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing RAB11FIP2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing RAB11FIP2
(According to HUGE)
About This Section
| |
Specialized Databases showing RAB11FIP2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for RAB11FIP2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for RAB11FIP2:

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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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