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RAB11FIP1 Gene

protein-coding   GIFtS: 53

GC08M037835
RAB11 family interacting protein 1 (class I)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
DKFZp686E2214 2
FLJ22524 1, 2
FLJ22622 1, 2
MGC78448 2
NOEL1A 2
RCP 1, 2, 3, 5
Rab11-FIP1 1, 3
rab11-FIP1 2
Descriptions
RAB11 coupling protein 2
RAB11 family interacting protein 1 2
RAB11 family interacting protein 1 (class I) 2
Rab effector protein 2
Rab-coupling protein 3
Rab-interacting recycling protein 2
External Ids
HGNC: 302651
Entrez Gene: 802232
UniProtKB: Q6WKZ43
Ensembl: ENSG000001566757
Search outside databases for aliases for RAB11FIP1 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for RAB11FIP1:
Proteins of the large Rab GTPase family (see RAB1A; MIM 179508) have regulatory roles in the
formation, targeting, and fusion of intracellular transport vesicles. RAB11FIP1 is one of many
proteins that interact with and regulate Rab GTPases (Hales et al., 2001 [PubMed
11495908]).[supplied by OMIM]

UniProtKB/Swiss-Prot: RFIP1_HUMAN, Q6WKZ4
Function: A Rab11 effector protein involved in the endosomal recycling process. Also involved in
controlling membrane trafficking along the phagocytic pathway and in phagocytosis

Gene Wiki entry for RAB11FIP1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the RAB11FIP1 gene  

Entrez Gene cytogenetic band: 8p11.22   Ensembl cytogenetic band:  8p12   HGNC cytogenetic band: 8p11.22

RAB11FIP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M037835:     (about GC identifiers)

Start:
37,835,628 bp from pter
End:
37,876,161 bp from pter
Size:
40,534 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000008.9  NT_007995.14  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: RFIP1_HUMAN, Q6WKZ4 (See protein sequence)
Recommended Name: Rab11 family-interacting protein 1  
Size: 1283 amino acids; 137195 Da
Subunit: Homooligomer (isoform 2). Isoform 2 interacts with RAB4A, RAB11A, RAB11B and RAB25.
According to PubMed:15280022, RAB4A binding to RAB11FIP1 is of very low affinity in vitro and in
vivo
Subcellular location: Recycling endosome. Note=Rab11A rather than Rab4A mediates localization in
the endocytic recycling compartment (ERC)
Subcellular location: Isoform 2: Cytoplasmic vesicle, phagosome membrane. Note=Membrane-bound
(isoform 2). Colocalizes with Rab11A at phagosomes (isoform 2)
Secondary accessions: Q6AZK4 Q6WKZ2 Q6WKZ6 Q86YV4 Q8TDL1 Q9H642
Alternative splicing: 5 isoforms:  Q6WKZ4-4   Q6WKZ4-3   Q6WKZ4-1   Q6WKZ4-2   Q6WKZ4-5   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (3 alternative transcripts): 
    NP_001002233.1  NP_001002814.1  NP_079427.3  


    ENSEMBL proteins: 
    ENSP00000331342 ENSP00000287263 ENSP00000340822 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (RAB11FIP1)
    Human Recombinant Proteins from Abnova (RAB11FIP1)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    3 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020 membrane IEA--
    GO:0031410 cytoplasmic vesicle IEA--
    GO:0055037 recycling endosome IEA--
    About this table

    Antibodies for RAB11FIP1: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for RAB11FIP1
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (RAB11FIP1), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (RAB11FIP1)
    Novus Biologicals Antibodies for RAB11FIP1

    Assays for RAB11FIP1: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    3 InterPro domains/families:
     IPR018029 C2_membr_targeting
     IPR019018 Rab11-bd_FIP_dom_C
     IPR000008 C2_Ca-dep


       GeneDecks  RAB11FIP1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q6WKZ4

    ProtoNet protein and cluster: Q6WKZ4

    1 Blocks protein family: IPB000008 C2 domain

    UniProtKB/Swiss-Prot: RFIP1_HUMAN, Q6WKZ4
    Similarity: Contains 1 C2 domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (RAB11FIP1)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001002233

                  Applied Biosystems Silencer® siRNAs for RAB11FIP1

                  Sigma-Aldrich siRNA for RAB11FIP1  
                         Sigma-Aldrich shRNA for RAB11FIP1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for RAB11FIP1
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001002233
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001002233
                                     untagged cDNA clones in CMV expression vector (see all 3): NM_001002233 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001002814

    UniProtKB/Swiss-Prot: RFIP1_HUMAN, Q6WKZ4
    Function: A Rab11 effector protein involved in the endosomal recycling process. Also involved in
    controlling membrane trafficking along the phagocytic pathway and in phagocytosis

    1 Gene Ontology (GO) molecular function term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515 protein binding IPI17353931
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


     Gene Network CentralTM Interacting Genes and Proteins Network for  RAB11FIP1 


    5/11 Interacting proteins for RAB11FIP1 (ENSP000003313423 Q6WKZ41) via UniProtKB, MINT, and/or STRING (see all 11 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAB11AP624911STRING (score=.999) EBI-1043591, EBI-745098
    RAB11FIP4ENSP000003128373STRING (score=.935)
    MYO5BENSP000002850393STRING (score=.873)
    TFENSP000002649983STRING (score=.769)
    RAB1AENSP000002606383STRING (score=.748)
    About this table

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015031 protein transport IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for RAB11FIP1

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (RAB11FIP1)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001002233

                  Sigma-Aldrich siRNA for RAB11FIP1  
                         Sigma-Aldrich shRNA for RAB11FIP1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001002233  NM_001002814  NM_025151  

    REFSEQ mRNAs for RAB11FIP1 gene (3 alternative transcripts): 

    NM_001002233.1   NM_001002814.1   NM_025151.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001002233  NM_001002814  NM_025151  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001002233
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001002233
                                     untagged cDNA clones in CMV expression vector (see all 3): NM_001002233 

    Additional cDNA sequence: 

    AF368294.1 AK026177.1 AK026275.1 AK090437.1 AK090578.1 AK092296.1 AK122583.1 AK124212.1 
    AK124422.1 AK226111.1 AK291781.1 AL832155.1 AL833169.1 AY280966.1 AY280967.1 AY280968.1 
    AY280969.1 AY280970.1 AY367050.1 BC001314.1 BC054881.1 BC077720.1 DQ083995.1 DQ236342.1 

    13 DOTS entries:

    DT.215820  DT.40287894  DT.97787022  DT.101973839  DT.92038095  DT.121481446  DT.91720697  DT.95297480 
    DT.95207159  DT.121481448  DT.121481470  DT.120923543  DT.95101316 

    24/235 AceView cDNA sequences (see all 235 ):

    AI338111 BU729432 AI628367 CA867938 AI478195 CA309188 CD368763 CB068559 
    AA581997 AA305313 AI420820 BQ774256 AA465732 CB989063 CB069834 NM_025151 
    BF438363 BF036438 BM994124 AI200103 BF476028 NM_001002233 CB159617 AI583182 

    highest scoring ESTs for RAB11FIP1:

    AA143793 AA622508 AF368294 AI678240 AY280968 BC054881 BE243311 BM689496 BX955251 CB989063 

    Unigene Cluster for RAB11FIP1:

    RAB11 family interacting protein 1 (class I)
    Hs.696035  [show with all ESTs]
    Unigene Representative Sequence: NM_001002814


    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RAB11FIP1

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b
    SP1:                                                  -               
    SP2:                                -     -           -               
    SP3:              -                 -     -           -               
    SP4:                                                                  
    SP5:                                                  -               

    About this scheme

    ECgene alternative splicing isoforms for RAB11FIP1

    3 Ensembl transcripts including schematic representations:
    ENST00000330843  ENST00000287263  ENST00000343853  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    RAB11FIP1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for RAB11FIP1

    1 / 2 / 3

    10 probe-sets matching RAB11FIP1 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    92071_at2, 3 U95-E 1 1.00 1.00 0.35 1.07 AA699588 0.60 1.00 0.82 1
    89338_at2, 3 U95-E 1 1.00 1.00 0.93 0.93 AA102335 0.60 1.00 0.82 1
    57608_at2, 3 U95-B 1 1.00 1.00 0.95 0.82 AA523335 0.60 1.00 0.82 1
    55686_at2, 3 U95-B 1 1.00 1.00 0.96 1.20 AA143793 0.80 1.00 0.91 1

    225177_at2, 3 U133-B 1 1.00 1.00 -- -- AA143793 0.80 1.00 0.91 1

    219681_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_025151 0.60 1.00 0.82 1

    231830_x_at2, 3 U133-B 5 0.82 0.86 -- -- BE544375 0.40 1.00 0.76 1

    225177_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    219681_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    231830_x_at2 U133Plus2 5 0.82 0.86 -- -- -- -- -- -- --
    GeneDecks  RAB11FIP1 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.696035

    UniProtKB/Swiss-Prot: RFIP1_HUMAN, Q6WKZ4
    Tissue specificity: Isoform 2 is expressed in brain, heart, testis, lung, spleen, ovary and small
    intestine

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for RAB11FIP1 gene from 5 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    RAB11FIP11   -- RAB11 family interacting protein 1 (class I) 80.32(n)
    71.94(a)
    482852  XM_539967.2  XP_539967.2 
    cow
    (Bos taurus)
    RAB11FIP11   -- RAB11 family interacting protein 1 (class I) 73.65(n)
    64.96(a)
    518839  XM_597040.3  XP_597040.2 
    mouse
    (Mus musculus)
    Rab11fip11, 5 85
    RAB11 family interacting protein 1 (class I)1, 5 75.52(n)1
    68.88(a)1
    757671  NM_001080813.11  NP_001074282.11 
     AK0084125  AK0146965  (see all 19)
    chicken
    (Gallus gallus)
    RAB11FIP11   -- RAB11 family interacting protein 1 (class I) 63.38(n)
    58.37(a)
    770622  XM_001233960.1  XP_001233961.1 
    zebrafish
    (Danio rerio)
    Dr.270962   -- Danio rerio cDNA clone IMAGE5605410, partial cds 77.01(n)  BC057524.1 
    About this table        Species with no ortholog for RAB11FIP1

    ENSEMBL Gene Tree for RAB11FIP1
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for RAB11FIP1 gene
    RAB11FIP22  RAB11FIP52  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/174 NCBI SNPs in RAB11FIP1 are shown (see all 174 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 39)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 8 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs10547481,2
    A,C,F,H,O37837626(-) TATGTA/GTGTCC 3 -- ut31 ese316Minor allele frequency- G:0.22MN NA EU EA WA 1518
    rs31925961,2
    A,C,F,H37836279(-) CTCATT/GCCTCA 1 -- ut31 ese312Minor allele frequency- G:0.18MN NA EU EA WA 1096
    rs73415641,2
    A,C,F,H37849614(+) GGCCTG/TGCCCC 3 Q/K mis1 int1 ut5112Minor allele frequency- N:0.01EA NA EU WA 1048
    rs78361861,2
    A,C,F,H37835460(+) AGGGCG/CTTGGG 1 -- ng5115Minor allele frequency- C:0.26NA EU EA WA 1398
    rs49565421,2
    C,F,H37877696(+) GCAACC/TGCGTT 2 -- ng3114Minor allele frequency- T:0.19EU EA WA NA 1438
    --
    rs78171791,2
    C,F,H37847175(+) TGGCCG/ATGGCA 3 M/T T/M mis111Minor allele frequency- A:0.11NA EU EA WA 938
    rs125416511,2
    C,F,H37849526(+) CCAGGA/GCAGAA 3 V/A mis1 int1 ut51 ese312Minor allele frequency- G:0.35EU EA WA NA 1050
    rs168870921,2
    C,F,H37849175(+) CTTCAG/ACTGCA 3 V/A mis1 int1 ese37Minor allele frequency- A:0.09NA EU EA WA 546
    rs70037041,2
    F,H37838052(+) CTTTTA/GTTAAC 3 -- ut31 ese34Minor allele frequency- G:0.03EU EA WA 418
    rs15397771,2
    A,H37851172(-) CTTCTC/AGTGCA 3 -- int1 ng317Minor allele frequency- A:0.00EA NA EU WA 470
    About this table

    HapMap Linkage Disequilibrium images for RAB11FIP1 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 608737

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/30 PubMed articles for RAB11FIP1 gene (see all 30 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 80223 HGNC: 30265 AceView: RAB11FIP1 Ensembl:ENSG00000156675 euGenes: HUgn80223
    ECgene: RAB11FIP1 H-InvDB: RAB11FIP1
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for RAB11FIP1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Predesigned and custom siRNAs for RAB11FIP1 Antibodies for RAB11FIP1
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