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Aliases for RAB11FIP1 Gene

Aliases for RAB11FIP1 Gene

  • RAB11 Family Interacting Protein 1 (Class I) 2 3
  • RCP 3 4 6
  • Rab11-FIP1 3 4
  • Rab11 Family-Interacting Protein 1 3
  • Rab-Interacting Recycling Protein 3
  • RAB11 Coupling Protein 3
  • Rab Effector Protein 3
  • Rab-Coupling Protein 4
  • EC 3.2.1.28 63
  • EC 6.1.1.7 63
  • NOEL1A 3

External Ids for RAB11FIP1 Gene

Previous GeneCards Identifiers for RAB11FIP1 Gene

  • GC08M037716
  • GC08M036250

Summaries for RAB11FIP1 Gene

Entrez Gene Summary for RAB11FIP1 Gene

  • This gene encodes one of the Rab11-family interacting proteins (Rab11-FIPs), which play a role in the Rab-11 mediated recycling of vesicles. The encoded protein may be involved in endocytic sorting, trafficking of proteins including integrin subunits and epidermal growth factor receptor (EGFR), and transport between the recycling endosome and the trans-Golgi network. Alternative splicing results in multiple transcript variants. A pseudogene is described on the X chromosome. [provided by RefSeq, Dec 2013]

GeneCards Summary for RAB11FIP1 Gene

RAB11FIP1 (RAB11 Family Interacting Protein 1 (Class I)) is a Protein Coding gene. Diseases associated with RAB11FIP1 include griscelli syndrome. Among its related pathways are Endocytosis and Cytoskeletal Signaling. An important paralog of this gene is RAB11FIP5.

UniProtKB/Swiss-Prot for RAB11FIP1 Gene

  • A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis.

Gene Wiki entry for RAB11FIP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB11FIP1 Gene

Genomics for RAB11FIP1 Gene

Regulatory Elements for RAB11FIP1 Gene

Genomic Location for RAB11FIP1 Gene

Start:
37,858,618 bp from pter
End:
37,899,497 bp from pter
Size:
40,880 bases
Orientation:
Minus strand

Genomic View for RAB11FIP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAB11FIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB11FIP1 Gene

Proteins for RAB11FIP1 Gene

  • Protein details for RAB11FIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6WKZ4-RFIP1_HUMAN
    Recommended name:
    Rab11 family-interacting protein 1
    Protein Accession:
    Q6WKZ4
    Secondary Accessions:
    • J3KNP0
    • Q307T1
    • Q6AZK4
    • Q6WKZ2
    • Q6WKZ6
    • Q86YV4
    • Q8TDL1
    • Q9H642

    Protein attributes for RAB11FIP1 Gene

    Size:
    1283 amino acids
    Molecular mass:
    137167 Da
    Quaternary structure:
    • Homooligomer (isoform 2). Isoform 2 interacts with RAB4A, RAB11A, RAB11B and RAB25. According to PubMed:15280022, RAB4A binding to RAB11FIP1 is of very low affinity in vitro and in vivo.

    Alternative splice isoforms for RAB11FIP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAB11FIP1 Gene

Proteomics data for RAB11FIP1 Gene at MOPED

Selected DME Specific Peptides for RAB11FIP1 Gene

Post-translational modifications for RAB11FIP1 Gene

  • Ubiquitination at Lys541
  • Modification sites at PhosphoSitePlus

Other Protein References for RAB11FIP1 Gene

Domains for RAB11FIP1 Gene

Protein Domains for RAB11FIP1 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q6WKZ4

UniProtKB/Swiss-Prot:

RFIP1_HUMAN :
  • Q6WKZ4
Domain:
  • Contains 1 C2 domain.
  • Contains 1 FIP-RBD domain.
genes like me logo Genes that share domains with RAB11FIP1: view

No data available for Gene Families for RAB11FIP1 Gene

Function for RAB11FIP1 Gene

Molecular function for RAB11FIP1 Gene

UniProtKB/Swiss-Prot Function: A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis.

Enzyme Numbers (IUBMB) for RAB11FIP1 Gene

Gene Ontology (GO) - Molecular Function for RAB11FIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0017137 Rab GTPase binding IBA --
genes like me logo Genes that share ontologies with RAB11FIP1: view

Phenotypes for RAB11FIP1 Gene

GenomeRNAi human phenotypes for RAB11FIP1:
genes like me logo Genes that share phenotypes with RAB11FIP1: view

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for RAB11FIP1 Gene

Localization for RAB11FIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB11FIP1 Gene

Recycling endosome. Note=Rab11A rather than Rab4A mediates localization in the endocytic recycling compartment (ERC).
Isoform 2: Cytoplasmic vesicle, phagosome membrane. Note=Membrane-bound (isoform 2). Colocalizes with Rab11A at phagosomes (isoform 2).

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB11FIP1 Gene COMPARTMENTS Subcellular localization image for RAB11FIP1 gene
Compartment Confidence
endosome 5
cytoskeleton 4
cytosol 4
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RAB11FIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005768 endosome --
GO:0016020 membrane --
GO:0030670 phagocytic vesicle membrane IEA --
GO:0031410 cytoplasmic vesicle --
genes like me logo Genes that share ontologies with RAB11FIP1: view

Pathways for RAB11FIP1 Gene

genes like me logo Genes that share pathways with RAB11FIP1: view

Pathways by source for RAB11FIP1 Gene

1 Cell Signaling Technology pathway for RAB11FIP1 Gene
1 KEGG pathway for RAB11FIP1 Gene
1 GeneGo (Thomson Reuters) pathway for RAB11FIP1 Gene

Gene Ontology (GO) - Biological Process for RAB11FIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport IEA --
GO:0045055 regulated secretory pathway IBA --
GO:0070164 negative regulation of adiponectin secretion IDA 24040321
genes like me logo Genes that share ontologies with RAB11FIP1: view

Transcripts for RAB11FIP1 Gene

Unigene Clusters for RAB11FIP1 Gene

RAB11 family interacting protein 1 (class I):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAB11FIP1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b
SP1: -
SP2: - - -
SP3: - - - -
SP4:
SP5: -

Relevant External Links for RAB11FIP1 Gene

GeneLoc Exon Structure for
RAB11FIP1
ECgene alternative splicing isoforms for
RAB11FIP1

Expression for RAB11FIP1 Gene

mRNA expression in normal human tissues for RAB11FIP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB11FIP1 Gene

This gene is overexpressed in Whole Blood (6.2), Esophagus - Mucosa (4.6), and Lung (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB11FIP1 Gene

SOURCE GeneReport for Unigene cluster for RAB11FIP1 Gene Hs.191179

mRNA Expression by UniProt/SwissProt for RAB11FIP1 Gene

Q6WKZ4-RFIP1_HUMAN
Tissue specificity: Isoform 2 is expressed in brain, heart, testis, lung, spleen, ovary and small intestine.
genes like me logo Genes that share expressions with RAB11FIP1: view

Orthologs for RAB11FIP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB11FIP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB11FIP1 35
  • 99.37 (n)
  • 98.68 (a)
RAB11FIP1 36
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RAB11FIP1 35
  • 73.29 (n)
  • 64.47 (a)
RAB11FIP1 36
  • 56 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GOT1L1 36
  • 67 (a)
OneToOne
RAB11FIP1 35
  • 80.18 (n)
  • 71.46 (a)
mouse
(Mus musculus)
Mammalia Rab11fip1 35
  • 75.09 (n)
  • 68.36 (a)
Rab11fip1 16
Rab11fip1 36
  • 57 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAB11FIP1 36
  • 49 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAB11FIP1 36
  • 42 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rab11fip1 35
  • 75.79 (n)
  • 69.85 (a)
chicken
(Gallus gallus)
Aves RAB11FIP1 36
  • 34 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAB11FIP1 36
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rab11fip1 35
  • 59.94 (n)
  • 54.92 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.27096 35
rab11fip1a 36
  • 13 (a)
ManyToMany
rab11fip1b 36
  • 23 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Rip11 36
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8553 36
  • 20 (a)
OneToMany
Species with no ortholog for RAB11FIP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAB11FIP1 Gene

ENSEMBL:
Gene Tree for RAB11FIP1 (if available)
TreeFam:
Gene Tree for RAB11FIP1 (if available)

Paralogs for RAB11FIP1 Gene

Paralogs for RAB11FIP1 Gene

Selected SIMAP similar genes for RAB11FIP1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for RAB11FIP1 Gene

genes like me logo Genes that share paralogs with RAB11FIP1: view

Variants for RAB11FIP1 Gene

Sequence variations from dbSNP and Humsavar for RAB11FIP1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1054748 -- 37,860,950(-) TATGT(A/G)TGTCC utr-variant-3-prime
rs1137155 -- 37,861,793(-) tgacc(A/G)acatg utr-variant-3-prime
rs1137156 -- 37,861,777(-) ACCCC(A/G)TCTCT utr-variant-3-prime
rs1137775 -- 37,885,674(-) TTTTT(C/T)TGCAT intron-variant
rs1539777 -- 37,874,496(-) CTTCT(A/C)GTGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB11FIP1 Gene

Variant ID Type Subtype PubMed ID
nsv509261 CNV Insertion 20534489
nsv528598 CNV Loss 19592680

Relevant External Links for RAB11FIP1 Gene

HapMap Linkage Disequilibrium report
RAB11FIP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB11FIP1 Gene

Disorders for RAB11FIP1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for RAB11FIP1 Gene including...

Search for RAB11FIP1 Gene in MalaCards »

(2) Novoseek inferred disease relationships for RAB11FIP1 Gene

Disease -log(P) Hits PubMed IDs
metastasis 3.44 1
breast cancer 0 4
genes like me logo Genes that share disorders with RAB11FIP1: view

No data available for UniProtKB/Swiss-Prot for RAB11FIP1 Gene

Publications for RAB11FIP1 Gene

  1. Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein. (PMID: 11786538) Lindsay A.J. … McCaffrey M.W. (J. Biol. Chem. 2002) 2 3 4 23
  2. Rab coupling protein associates with phagosomes and regulates recycling from the phagosomal compartment. (PMID: 15355514) Damiani M.T. … Colombo M.I. (Traffic 2004) 3 4 23
  3. The Rab11-FIP1/RCP gene codes for multiple protein transcripts related to the plasma membrane recycling system. (PMID: 16920206) Jin M. … Goldenring J.R. (Biochim. Biophys. Acta 2006) 3 4 23
  4. The RCP-Rab11 complex regulates endocytic protein sorting. (PMID: 15181150) Peden A.A. … Prekeris R. (Mol. Biol. Cell 2004) 3 4 23
  5. Characterisation of the Rab binding properties of Rab coupling protein (RCP) by site-directed mutagenesis. (PMID: 15280022) Lindsay A.J. … McCaffrey M.W. (FEBS Lett. 2004) 3 4 23

Products for RAB11FIP1 Gene

Sources for RAB11FIP1 Gene

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