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Aliases for RAB11FIP1 Gene

Aliases for RAB11FIP1 Gene

  • RAB11 Family Interacting Protein 1 2 3 5
  • RAB11 Family Interacting Protein 1 (Class I) 2 3
  • Rab11-FIP1 3 4
  • RCP 3 4
  • Rab11 Family-Interacting Protein 1 3
  • Rab-Interacting Recycling Protein 3
  • RAB11 Coupling Protein 3
  • Rab Effector Protein 3
  • Rab-Coupling Protein 4
  • EC 3.2.1.28 58
  • EC 6.1.1.7 58
  • NOEL1A 3

External Ids for RAB11FIP1 Gene

Previous GeneCards Identifiers for RAB11FIP1 Gene

  • GC08M037716
  • GC08M036250

Summaries for RAB11FIP1 Gene

Entrez Gene Summary for RAB11FIP1 Gene

  • This gene encodes one of the Rab11-family interacting proteins (Rab11-FIPs), which play a role in the Rab-11 mediated recycling of vesicles. The encoded protein may be involved in endocytic sorting, trafficking of proteins including integrin subunits and epidermal growth factor receptor (EGFR), and transport between the recycling endosome and the trans-Golgi network. Alternative splicing results in multiple transcript variants. A pseudogene is described on the X chromosome. [provided by RefSeq, Dec 2013]

GeneCards Summary for RAB11FIP1 Gene

RAB11FIP1 (RAB11 Family Interacting Protein 1) is a Protein Coding gene. Among its related pathways are wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF) and Cytoskeletal Signaling. GO annotations related to this gene include Rab GTPase binding. An important paralog of this gene is RAB11FIP2.

UniProtKB/Swiss-Prot for RAB11FIP1 Gene

  • A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis.

Gene Wiki entry for RAB11FIP1 Gene

Additional gene information for RAB11FIP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB11FIP1 Gene

Genomics for RAB11FIP1 Gene

Regulatory Elements for RAB11FIP1 Gene

Enhancers for RAB11FIP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H037889 2.1 FANTOM5 Ensembl ENCODE dbSUPER 22.4 +1.6 1590 17 ZFP64 FEZF1 DMAP1 SP3 ZC3H11A MEF2D GLIS1 NBN NR2C1 KDM1A ENSG00000255201 ADGRA2 NSD3 DDHD2 ERLIN2 FGFR1 LOC728024 RAB11FIP1 RPS20P22 ASH2L
GH08H037879 2 FANTOM5 Ensembl ENCODE dbSUPER 15.3 +15.8 15815 8 HDGF PKNOX1 ATF1 SIN3A ZNF2 ZNF121 GATA2 ZNF143 ZNF207 FOS RAB11FIP1 LOC100507403 NSD3 BAG4 ENSG00000280064
GH08H037796 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.9 +98.7 98719 9 PKNOX1 ATF1 ARNT ZNF133 SIN3A ZNF2 ZNF143 ATF7 TSHZ1 ZNF592 GOT1L1 RAB11FIP1 PLPBP ADGRA2 GC08M037706 GC08P037815
GH08H037869 1.4 Ensembl ENCODE dbSUPER 13.3 +26.7 26747 6 HDGF PKNOX1 SIN3A BMI1 BATF ZNF366 ZNF143 FOS ATF7 RCOR1 RAB11FIP1 ADGRA2 GOT1L1 EIF4EBP1 PLPBP ENSG00000280064
GH08H037862 1.2 ENCODE dbSUPER 13 +35.9 35854 3 HDAC1 ATF1 KLF17 ZNF766 GATA2 ZNF366 ATF7 CREM ZBTB11 CEBPB RAB11FIP1 ADGRA2 EIF4EBP1 GOT1L1 RNU6-323P ENSG00000280064
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RAB11FIP1 on UCSC Golden Path with GeneCards custom track

Promoters for RAB11FIP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000223598 697 2401 ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF766 ZNF207 SP3 SP5 MXD4

Genomic Location for RAB11FIP1 Gene

Chromosome:
8
Start:
37,858,618 bp from pter
End:
37,899,497 bp from pter
Size:
40,880 bases
Orientation:
Minus strand

Genomic View for RAB11FIP1 Gene

Genes around RAB11FIP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB11FIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB11FIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB11FIP1 Gene

Proteins for RAB11FIP1 Gene

  • Protein details for RAB11FIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6WKZ4-RFIP1_HUMAN
    Recommended name:
    Rab11 family-interacting protein 1
    Protein Accession:
    Q6WKZ4
    Secondary Accessions:
    • J3KNP0
    • Q307T1
    • Q6AZK4
    • Q6WKZ2
    • Q6WKZ6
    • Q86YV4
    • Q8TDL1
    • Q9H642

    Protein attributes for RAB11FIP1 Gene

    Size:
    1283 amino acids
    Molecular mass:
    137167 Da
    Quaternary structure:
    • Homooligomer (isoform 2). Isoform 2 interacts with RAB4A, RAB11A, RAB11B and RAB25. According to PubMed:15280022, RAB4A binding to RAB11FIP1 is of very low affinity in vitro and in vivo.

    Three dimensional structures from OCA and Proteopedia for RAB11FIP1 Gene

    Alternative splice isoforms for RAB11FIP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAB11FIP1 Gene

Selected DME Specific Peptides for RAB11FIP1 Gene

Q6WKZ4:
  • VNFTLPK
  • QAGSLVE

Post-translational modifications for RAB11FIP1 Gene

  • Ubiquitination at isoforms=4, 3541
  • Modification sites at PhosphoSitePlus

Other Protein References for RAB11FIP1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RAB11FIP1 (RAB11FIP1)

Domains & Families for RAB11FIP1 Gene

Gene Families for RAB11FIP1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RAB11FIP1 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RAB11FIP1: view

No data available for UniProtKB/Swiss-Prot for RAB11FIP1 Gene

Function for RAB11FIP1 Gene

Molecular function for RAB11FIP1 Gene

UniProtKB/Swiss-Prot Function:
A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis.

Enzyme Numbers (IUBMB) for RAB11FIP1 Gene

Phenotypes From GWAS Catalog for RAB11FIP1 Gene

Gene Ontology (GO) - Molecular Function for RAB11FIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17353931
GO:0017137 Rab GTPase binding IBA --
genes like me logo Genes that share ontologies with RAB11FIP1: view
genes like me logo Genes that share phenotypes with RAB11FIP1: view

Animal Model Products

CRISPR Products

miRNA for RAB11FIP1 Gene

miRTarBase miRNAs that target RAB11FIP1

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RAB11FIP1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB11FIP1 Gene

Localization for RAB11FIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB11FIP1 Gene

Recycling endosome. Note=Rab11A rather than Rab4A mediates localization in the endocytic recycling compartment (ERC).
Isoform 2: Cytoplasmic vesicle, phagosome membrane. Note=Membrane-bound (isoform 2). Colocalizes with Rab11A at phagosomes (isoform 2).

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB11FIP1 gene
Compartment Confidence
cytosol 5
endosome 4
plasma membrane 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RAB11FIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005768 endosome IEA --
GO:0005829 cytosol IDA --
GO:0016020 membrane IEA --
GO:0030670 phagocytic vesicle membrane IEA --
genes like me logo Genes that share ontologies with RAB11FIP1: view

Pathways & Interactions for RAB11FIP1 Gene

genes like me logo Genes that share pathways with RAB11FIP1: view

Pathways by source for RAB11FIP1 Gene

1 Cell Signaling Technology pathway for RAB11FIP1 Gene
1 KEGG pathway for RAB11FIP1 Gene
1 GeneGo (Thomson Reuters) pathway for RAB11FIP1 Gene

Gene Ontology (GO) - Biological Process for RAB11FIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0015031 protein transport IEA --
GO:0045055 regulated exocytosis IBA --
GO:0070164 negative regulation of adiponectin secretion IDA 24040321
genes like me logo Genes that share ontologies with RAB11FIP1: view

No data available for SIGNOR curated interactions for RAB11FIP1 Gene

Drugs & Compounds for RAB11FIP1 Gene

No Compound Related Data Available

Transcripts for RAB11FIP1 Gene

Unigene Clusters for RAB11FIP1 Gene

RAB11 family interacting protein 1 (class I):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RAB11FIP1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for RAB11FIP1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b
SP1: -
SP2: - - -
SP3: - - - -
SP4:
SP5: -

Relevant External Links for RAB11FIP1 Gene

GeneLoc Exon Structure for
RAB11FIP1
ECgene alternative splicing isoforms for
RAB11FIP1

Expression for RAB11FIP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAB11FIP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB11FIP1 Gene

This gene is overexpressed in Whole Blood (x6.2), Esophagus - Mucosa (x4.6), and Lung (x4.6).

Protein differential expression in normal tissues from HIPED for RAB11FIP1 Gene

This gene is overexpressed in Nasal epithelium (14.1), Cervix (10.4), and Peripheral blood mononuclear cells (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RAB11FIP1 Gene



NURSA nuclear receptor signaling pathways regulating expression of RAB11FIP1 Gene:

RAB11FIP1

SOURCE GeneReport for Unigene cluster for RAB11FIP1 Gene:

Hs.191179

mRNA Expression by UniProt/SwissProt for RAB11FIP1 Gene:

Q6WKZ4-RFIP1_HUMAN
Tissue specificity: Isoform 2 is expressed in brain, heart, testis, lung, spleen, ovary and small intestine.

Evidence on tissue expression from TISSUES for RAB11FIP1 Gene

  • Intestine(4.5)
  • Lung(4.5)
  • Stomach(4.3)
  • Spleen(4.2)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with RAB11FIP1: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAB11FIP1 Gene

Orthologs for RAB11FIP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB11FIP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB11FIP1 33 34
  • 99.37 (n)
dog
(Canis familiaris)
Mammalia RAB11FIP1 33
  • 80.18 (n)
GOT1L1 34
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rab11fip1 33
  • 75.79 (n)
mouse
(Mus musculus)
Mammalia Rab11fip1 34 16 33
  • 75.09 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RAB11FIP1 33 34
  • 73.29 (n)
oppossum
(Monodelphis domestica)
Mammalia RAB11FIP1 34
  • 49 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAB11FIP1 34
  • 42 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAB11FIP1 34
  • 34 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAB11FIP1 34
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rab11fip1 33
  • 59.94 (n)
zebrafish
(Danio rerio)
Actinopterygii rab11fip1b 34
  • 23 (a)
ManyToMany
rab11fip1a 34
  • 13 (a)
ManyToMany
Dr.27096 33
fruit fly
(Drosophila melanogaster)
Insecta Rip11 34
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8553 34
  • 20 (a)
OneToMany
Species where no ortholog for RAB11FIP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAB11FIP1 Gene

ENSEMBL:
Gene Tree for RAB11FIP1 (if available)
TreeFam:
Gene Tree for RAB11FIP1 (if available)

Paralogs for RAB11FIP1 Gene

Paralogs for RAB11FIP1 Gene

(4) SIMAP similar genes for RAB11FIP1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for RAB11FIP1 Gene

genes like me logo Genes that share paralogs with RAB11FIP1: view

Variants for RAB11FIP1 Gene

Sequence variations from dbSNP and Humsavar for RAB11FIP1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000112202 -- 37,878,097(+) CGCTA(C/G)ACAAA intron-variant
rs1000196590 -- 37,898,883(+) AGCTG(A/G)CAGAG intron-variant
rs1000295767 -- 37,877,904(+) TAGTA(A/G)AGATG intron-variant
rs1000472151 -- 37,861,422(+) CCACA(A/G)ATAAT utr-variant-3-prime
rs1000480919 -- 37,873,604(+) GTCTC(-/A)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB11FIP1 Gene

Variant ID Type Subtype PubMed ID
nsv509261 CNV insertion 20534489
nsv528598 CNV loss 19592680

Variation tolerance for RAB11FIP1 Gene

Residual Variation Intolerance Score: 92.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.80; 89.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAB11FIP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAB11FIP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB11FIP1 Gene

Disorders for RAB11FIP1 Gene

Relevant External Links for RAB11FIP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAB11FIP1

No disorders were found for RAB11FIP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB11FIP1 Gene

Publications for RAB11FIP1 Gene

  1. Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein. (PMID: 11786538) Lindsay AJ … McCaffrey MW (The Journal of biological chemistry 2002) 2 3 4 22 60
  2. The Rab11-FIP1/RCP gene codes for multiple protein transcripts related to the plasma membrane recycling system. (PMID: 16920206) Jin M … Goldenring JR (Biochimica et biophysica acta 2006) 3 4 22 60
  3. Rab coupling protein associates with phagosomes and regulates recycling from the phagosomal compartment. (PMID: 15355514) Damiani MT … Colombo MI (Traffic (Copenhagen, Denmark) 2004) 3 4 22 60
  4. Characterisation of the Rab binding properties of Rab coupling protein (RCP) by site-directed mutagenesis. (PMID: 15280022) Lindsay AJ … McCaffrey MW (FEBS letters 2004) 3 4 22 60
  5. The RCP-Rab11 complex regulates endocytic protein sorting. (PMID: 15181150) Peden AA … Prekeris R (Molecular biology of the cell 2004) 3 4 22 60

Products for RAB11FIP1 Gene

Sources for RAB11FIP1 Gene

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