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Aliases & Descriptions for RAB11FIP1
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases DKFZp686E2214 2 FLJ22524 1 , 2 FLJ22622 1 , 2 MGC78448 2 NOEL1A 2 RCP 1 , 2 , 3 , 5 Rab11-FIP1 1 , 3 rab11-FIP1 2
Descriptions RAB11 coupling protein 2 RAB11 family interacting protein 1 2 RAB11 family interacting protein 1 (class I) 2 Rab effector protein 2 Rab-coupling protein 3 Rab-interacting recycling protein 2
Search outside databases for aliases for RAB11FIP1 gene
Summaries for RAB11FIP1 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
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EntrezGene summary for RAB11FIP1 : Proteins of the large Rab GTPase family (see RAB1A; MIM 179508) have regulatory roles in theformation, targeting, and fusion of intracellular transport vesicles. RAB11FIP1 is one of manyproteins that interact with and regulate Rab GTPases (Hales et al., 2001 [PubMed11495908]).[supplied by OMIM] UniProtKB/Swiss-Prot: RFIP1_HUMAN, Q6WKZ4 Function : A Rab11 effector protein involved in the endosomal recycling process. Also involved incontrolling membrane trafficking along the phagocytic pathway and in phagocytosis
Gene Wiki entry for RAB11FIP1
Genomic Location for RAB11FIP1
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the RAB11FIP1 gene Entrez Gene cytogenetic band: 8p11.22 Ensembl cytogenetic band: 8p12 HGNC cytogenetic band: 8p11.22 RAB11FIP1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure
GeneLoc location for GC08M037835:
(about GC identifiers )
Start:
37,835,628 bp from pter
End:
37,876,161 bp from pter
Size:
40,534 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000008.9 NT_007995.14 Proteins for RAB11FIP1
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
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OriGene and/or,
Abcam ,
Biochemical Assays by
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Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: RFIP1_HUMAN, Q6WKZ4 (See
protein sequence )Recommended Name: Rab11 family-interacting protein 1 Size : 1283 amino acids; 137195 Da
Subunit : Homooligomer (isoform 2). Isoform 2 interacts with RAB4A, RAB11A, RAB11B and RAB25.According to PubMed:15280022, RAB4A binding to RAB11FIP1 is of very low affinity in vitro and invivo
Subcellular location : Recycling endosome. Note=Rab11A rather than Rab4A mediates localization inthe endocytic recycling compartment (ERC)
Subcellular location : Isoform 2: Cytoplasmic vesicle, phagosome membrane. Note=Membrane-bound(isoform 2). Colocalizes with Rab11A at phagosomes (isoform 2)
Secondary accessions : Q6AZK4 Q6WKZ2 Q6WKZ6 Q86YV4 Q8TDL1 Q9H642Alternative splicing : 5 isoforms : Q6WKZ4-4 Q6WKZ4-3 Q6WKZ4-1 Q6WKZ4-2 Q6WKZ4-5
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (3 alternative transcripts):
NP_001002233.1 NP_001002814.1 NP_079427.3 ENSEMBL proteins: ENSP00000331342 ENSP00000287263 ENSP00000340822 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 3 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for RAB11FIP1: Assays for RAB11FIP1:
Protein
Domains/ Families for RAB11FIP1(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q6WKZ4 ProtoNet protein and cluster: Q6WKZ4
1 Blocks protein family : IPB000008 C2 domain UniProtKB/Swiss-Prot: RFIP1_HUMAN, Q6WKZ4 Similarity : Contains 1 C2 domain
Gene Function for RAB11FIP1
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
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Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_001002233 Applied Biosystems Silencer ® siRNAs for RAB11FIP1 Sigma-Aldrich siRNA for RAB11FIP1 Sigma-Aldrich shRNA for RAB11FIP1 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_001002233                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_001002233                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_001002233  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001002814 UniProtKB/Swiss-Prot: RFIP1_HUMAN, Q6WKZ4 Function : A Rab11 effector protein involved in the endosomal recycling process. Also involved incontrolling membrane trafficking along the phagocytic pathway and in phagocytosis
1 Gene Ontology (GO) molecular function term (links to tree view) :
About this table
Pathways & Interactions for RAB11FIP1
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for RAB11FIP1 5/11 Interacting proteins for RAB11FIP1 (ENSP00000331342 3 Q6WKZ4 1 ) via UniProtKB, MINT, and/or STRING (see all 11
)About this table 1 Gene Ontology (GO) biological process term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0015031 protein transport
IEA --
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Drugs & Compounds for RAB11FIP1 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
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Novoseek and Drugs according to
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Browse Tocris compounds for RAB11FIP1
Transcripts for RAB11FIP1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_001002233 Sigma-Aldrich siRNA for RAB11FIP1 Sigma-Aldrich shRNA for RAB11FIP1 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001002233 NM_001002814 NM_025151
REFSEQ mRNAs for RAB11FIP1 gene (3 alternative transcripts): NM_001002233.1 NM_001002814.1 NM_025151.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001002233 NM_001002814 NM_025151
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_001002233                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_001002233                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_001002233  
Additional cDNA sequence: AF368294.1 AK026177.1 AK026275.1 AK090437.1 AK090578.1 AK092296.1 AK122583.1 AK124212.1 AK124422.1 AK226111.1 AK291781.1 AL832155.1 AL833169.1 AY280966.1 AY280967.1 AY280968.1 AY280969.1 AY280970.1 AY367050.1 BC001314.1 BC054881.1 BC077720.1 DQ083995.1 DQ236342.1
13 DOTS entries : DT.215820 DT.40287894 DT.97787022 DT.101973839 DT.92038095 DT.121481446 DT.91720697 DT.95297480 DT.95207159 DT.121481448 DT.121481470 DT.120923543 DT.95101316
24/235 AceView cDNA sequences (see all 235
):AI338111 BU729432 AI628367 CA867938 AI478195 CA309188 CD368763 CB068559 AA581997 AA305313 AI420820 BQ774256 AA465732 CB989063 CB069834 NM_025151 BF438363 BF036438 BM994124 AI200103 BF476028 NM_001002233 CB159617 AI583182
highest scoring ESTs for RAB11FIP1 :AA143793 AA622508 AF368294 AI678240 AY280968 BC054881 BE243311 BM689496 BX955251 CB989063
Unigene Cluster for RAB11FIP1: RAB11 family interacting protein 1 (class I) Hs.696035 [show with all ESTs ] Unigene Representative Sequence: NM_001002814 GeneLoc Exon Structure 5 Alternative Splicing Database (ASD) splice patterns (SP) for RAB11FIP1 ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b SP1 :                 -       SP2 :           -   -     -       SP3 :     -       -   -     -       SP4 :                       SP5 :                 -      
About this scheme ECgene alternative splicing isoforms for RAB11FIP1 3 Ensembl transcripts including schematic representations : ENST00000330843
ENST00000287263
ENST00000343853
Expression for RAB11FIP1
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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RAB11FIP1 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for RAB11FIP1 1 / 2 / 3
10 probe-sets matching RAB11FIP1 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: --SOURCE GeneReport for Unigene cluster: Hs.696035 UniProtKB/Swiss-Prot: RFIP1_HUMAN, Q6WKZ4 Tissue specificity : Isoform 2 is expressed in brain, heart, testis, lung, spleen, ovary and smallintestine
Orthologs for RAB11FIP1
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for RAB11FIP1 gene from 5 species
About this table Species with no ortholog for RAB11FIP1 ENSEMBL Gene Tree for RAB11FIP1 Paralogs for RAB11FIP1 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for RAB11FIP1 gene RAB11FIP2 2 RAB11FIP5 2
SNPs/Variants for RAB11FIP1 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for RAB11FIP1 (up to first 250kb)
Disorders & Mutations for RAB11FIP1
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
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and/or TGDB .)
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OMIM: 608737
Medical News for RAB11FIP1 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for RAB11FIP1 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/30 PubMed articles for RAB11FIP1 gene (see all 30
): Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein. (PubMed id 11786538) 1, 2, 3, 4 Lindsay A.J.... McCaffrey M.W. (2002) Identification and characterization of a family of Rab11-interacting proteins. (PubMed id 11495908) 2, 3, 4 Hales C.M....Goldenring J.R. (2001) Rab coupling protein associates with phagosomes and regulates recycling from the phagosomal compartment. (PubMed id 15355514) 1, 3, 4 Damiani M.T....Colombo M.I. (2004) Characterisation of the Rab binding properties of Rab coupling protein (RCP) by site-directed mutagenesis. (PubMed id 15280022) 1, 3, 4 Lindsay A.J. and McCaffrey M.W. (2004) The RCP-Rab11 complex regulates endocytic protein sorting. (PubMed id 15181150) 1, 3, 4 Peden A.A....Prekeris R. (2004) A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243) 3, 4 Beausoleil S.A.... Gygi S.P. (2006) Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983) 3, 4 Olsen J.V....Mann M. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 3, 4 Ota T....Sugano S. (2004) The novel Rab11-FIP/Rip/RCP family of proteins displays extensive homo- and hetero-interacting abilities. (PubMed id 11944901) 3, 4 Wallace D.M.... McCaffrey M.W. (2002)
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Genome Databases showing RAB11FIP1
(According to
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AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing RAB11FIP1
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Specialized Databases showing RAB11FIP1 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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