Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RAB11B Gene

protein-coding   GIFtS: 61
GCID: GC19P008455

RAB11B, Member RAS Oncogene Family

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
RAB11B, Member RAS Oncogene Family1 2
GTP-Binding Protein YPT32 3
H-YPT32
RAB11B, Member Of RAS Oncogene Family2
Ras-Related Protein Rab-11B2
YPT33

External Ids:    HGNC: 97611   Entrez Gene: 92302   Ensembl: ENSG000001852367   OMIM: 6041985   UniProtKB: Q159073   

Export aliases for RAB11B gene to outside databases

Previous GC identifers: GC19P008396 GC19P008546 GC19P008350 GC19P008361 GC19P008108


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RAB11B Gene:
The Ras superfamily of small GTP-binding proteins, which includes the Ras (see MIM 190020), Ral (see MIM 179550),
Rho (see MIM 165390), Rap (see MIM 179520), and Rab (see MIM 179508) families, is involved in controlling a
diverse set of essential cellular functions. The Rab family, including RAB11B, appears to play a critical role in
regulating exocytotic and endocytotic pathways (summary by Zhu et al., 1994 (PubMed 7811277)).(supplied by OMIM,
Nov 2010)

GeneCards Summary for RAB11B Gene: 
RAB11B (RAB11B, member RAS oncogene family) is a protein-coding gene. Diseases associated with RAB11B include cystic fibrosis, and hepatocellular carcinoma, and among its related super-pathways are Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include GDP binding and GTP binding. An important paralog of this gene is RAB19.

UniProtKB/Swiss-Prot: RB11B_HUMAN, Q15907
Function: GTPase that modulates endosomal trafficking. Acts as a major regulator of membrane delivery during
cytokinesis (By similarity)

Gene Wiki entry for RAB11B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_077812.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RAB11B gene promoter:
         AhR   GR   p53   AML1a   Pax-5   GR-beta   p300   Olf-1   GR-alpha   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRAB11B promoter sequence
   Search SABiosciences Chromatin IP Primers for RAB11B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB11B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

RAB11B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAB11B gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P008455:  view genomic region     (about GC identifiers)

Start:
8,454,865 bp from pter      End:
8,469,318 bp from pter
Size:
14,454 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RB11B_HUMAN, Q15907 (See protein sequence)
Recommended Name: Ras-related protein Rab-11B precursor  
Size: 218 amino acids; 24489 Da
Subunit: Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 and RAB11FIP4. May interact with TBC1D14
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Cytoplasmic vesicle, phagosome.
Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side (By similarity). Note=Recruited to
phagosomes containing S.aureus or M.tuberculosis
2 PDB 3D structures from and Proteopedia for RAB11B:
2F9L (3D)        2F9M (3D)    
Secondary accessions: B2R7I4 D6W671 Q2YDT2 Q8NI07

Explore the universe of human proteins at neXtProt for RAB11B: NX_Q15907

Explore proteomics data for RAB11B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15907

  • RAB11B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RAB11B Protein Expression
    REFSEQ proteins: NP_004209.2  
    ENSEMBL proteins: 
     ENSP00000473042   ENSP00000333547   ENSP00000472473   ENSP00000471148  

    Human Recombinant Protein Products for RAB11B: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for RAB11B
    OriGene Protein Over-expression Lysate for RAB11B
    OriGene MassSpec for RAB11B 
    OriGene Custom Protein Services for RAB11B
    GenScript Custom Purified and Recombinant Proteins Services for RAB11B
    Novus Biologicals RAB11B Proteins
    Novus Biologicals RAB11B Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RAB11B 

    Gene Ontology (GO): 5/13 cellular component terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion IEA--
    GO:0005886plasma membrane ----
    GO:0008021synaptic vesicle ISS--

    RAB11B for ontologies           About GeneDecksing



    RAB11B Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for RAB11B 
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for RAB11B
    GenScript Custom Superior Antibodies Services for RAB11B
    Novus Biologicals RAB11B Antibodies
    Abcam antibodies for RAB11B
    Cloud-Clone Corp. Antibodies for RAB11B 
    ThermoFisher Antibody for RAB11B
    LSBio Antibodies in human, mouse, rat for RAB11B 

    Assay Products for RAB11B: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RAB11B
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RAB11B
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RAB11B 
    Cloud-Clone Corp. CLIAs for RAB11B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RAB: RAB, member RAS oncogene

    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR003579 Small_GTPase_Rab_type
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q15907

    ProtoNet protein and cluster: Q15907

    1 Blocks protein domain: IPB001806 Transforming protein P21 RAS signature

    UniProtKB/Swiss-Prot: RB11B_HUMAN, Q15907
    Similarity: Belongs to the small GTPase superfamily. Rab family


    RAB11B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RB11B_HUMAN, Q15907
    Function: GTPase that modulates endosomal trafficking. Acts as a major regulator of membrane delivery during
    cytokinesis (By similarity)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IDA16545962
    GO:0005515protein binding IPI--
    GO:0005525GTP binding IDA16545962
    GO:0019003GDP binding IDA16545962
         
    RAB11B for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for RAB11B:
     Decreased cilium length after   Decreased viability after Chla  Decreased viability of wild-ty 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RAB11B 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RAB11B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RAB11B 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RAB11B 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAB11B
    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate RAB11B (see all 24):
    hsa-miR-142-5p hsa-miR-495 hsa-miR-1321 hsa-miR-520d-5p hsa-miR-300 hsa-miR-137 hsa-let-7a-2* hsa-miR-340
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RAB11B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAB11B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RAB11B
    Sirion Biotech Customized adenovirus for overexpression of RAB11B

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for RAB11B (see all 7)
    OriGene ORF clones in mouse, rat for RAB11B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RAB11B (NM_004218)
    Sino Biological Human cDNA Clone for RAB11B
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAB11B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB11B
    Sirion Biotech Customized lentivirus for stable overexpression of RAB11B 
                         Customized lentivirus expression plasmids for stable overexpression of RAB11B 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RAB11B
    Search LifeMap BioReagents cell lines for RAB11B
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB11B


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RAB11B About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions0.36
    2Vasopressin-regulated water reabsorption
    Vasopressin-regulated water reabsorption
    3Endocytosis
    Endocytosis
    4Cytoskeletal Signaling
    Cytoskeletal Signaling
    5Remodeling of Adherens Junctions
    Remodeling of Adherens Junctions

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RAB11B
        Remodeling of Adherens Junctions
    Epithelial Tight Junctions

    1 Cell Signaling Technology (CST) Pathway for RAB11B
        Cytoskeletal Signaling



    2         Kegg Pathways  (Kegg details for RAB11B):
        Endocytosis
    Vasopressin-regulated water reabsorption


    RAB11B for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAB11B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/84 Interacting proteins for RAB11B (Q159073 ENSP000003335474) via UniProtKB, MINT, STRING, and/or I2D (see all 84)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000096150P622693I2D: score=1 
    ENSG00000223367P622693I2D: score=1 
    ENSG00000226225P622693I2D: score=1 
    ENSG00000235650P622693I2D: score=1 
    RPS18P622693I2D: score=1 
    About this table

    Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001881receptor recycling ISS--
    GO:0006184GTP catabolic process IDA16545962
    GO:0006886intracellular protein transport ----
    GO:0006913nucleocytoplasmic transport ----
    GO:0007049cell cycle ----

    RAB11B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RAB11B (RB11B)

    Search CenterWatch for drugs/clinical trials and news about RAB11B / RB11B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RAB11B gene: 
    NM_004218.3  

    Unigene Cluster for RAB11B:

    RAB11B, member RAS oncogene family
    Hs.626404  [show with all ESTs]
    Unigene Representative Sequence: NM_004218
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000600719 ENST00000328024(uc002mju.4) ENST00000598706 ENST00000601897
    ENST00000594216
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAB11B
    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate RAB11B (see all 24):
    hsa-miR-142-5p hsa-miR-495 hsa-miR-1321 hsa-miR-520d-5p hsa-miR-300 hsa-miR-137 hsa-let-7a-2* hsa-miR-340
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RAB11B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAB11B
    Clone
    Products:
         
    OriGene clones in human, mouse for RAB11B (see all 7)
    OriGene ORF clones in mouse, rat for RAB11B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RAB11B (NM_004218)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAB11B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB11B
    Sirion Biotech Customized lentivirus for stable overexpression of RAB11B 
                         Customized lentivirus expression plasmids for stable overexpression of RAB11B 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RAB11B
    OriGene qSTAR qPCR primer pairs in human, mouse for RAB11B
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RAB11B
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAB11B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAB11B

    Additional mRNA sequence: 

    AF498947.1 AK225036.1 AK225642.1 AK297498.1 AK310573.1 AK312994.1 BC110081.1 BT019535.1 
    BT019536.1 CR536494.1 CR541691.1 D38516.1 EF560724.1 X79780.1 

    24/25 DOTS entries (see all 25):

    DT.100654291  DT.91777995  DT.100643817  DT.432925  DT.121477825  DT.91777990  DT.95176044  DT.100654296 
    DT.91777997  DT.100654281  DT.121477712  DT.100759077  DT.100654282  DT.75146769  DT.121477716  DT.121477754 
    DT.121477755  DT.121477794  DT.91777989  DT.92056983  DT.95176029  DT.95176045  DT.95176047  DT.100683225 

    24/632 AceView cDNA sequences (see all 632):

    BF686357 BQ019187 BE563240 BU151538 BG152662 CR594452 CR592057 BM696615 
    BQ772283 BU557276 BI092618 AA687467 BQ931678 BI490072 BQ427466 N40966 
    AI433983 BM669994 BE674749 BI918142 BQ882267 BE250804 AW160512 BU501211 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for RAB11B (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6a · 6b
    SP1:                                                                                -     -               
    SP2:                                                              -                 -     -               
    SP3:        -     -     -     -     -                                                                     
    SP4:                                                                                                      
    SP5:                                            -     -                                                   


    ECgene alternative splicing isoforms for RAB11B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RAB11B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAACTCGGGT
    RAB11B Expression
    About this image


    See RAB11B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RAB11B

    SOURCE GeneReport for Unigene cluster: Hs.626404
        SABiosciences Custom PCR Arrays for RAB11B
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RAB11B
    OriGene qSTAR qPCR primer pairs in human, mouse for RAB11B
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RAB11B
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAB11B
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAB11B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB11B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RAB11B gene from 9/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rab11b1 , 5 RAB11B, member RAS oncogene family1, 5 91.44(n)1
    99.08(a)1
      17 (17.98 cM)5
    193261  NM_008997.31  NP_033023.11 
     337424845 
    chicken
    (Gallus gallus)
    Aves RAB11B1 RAB11B, member RAS oncogene family 83.18(n)
    98.62(a)
      420063  NM_001012551.1  NP_001012569.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia rab11b-prov2 RAB11B, member RAS oncogene family 79.37(n)    BC041250.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb07g112 Danio rerio cDNA clone MGC55760 IMAGE3816634, complete more 82.34(n)    BC048889.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rab113 endocytosis GTP binding 83(a)   93B13   --
    worm
    (Caenorhabditis elegans)
    Secernentea rab-11.13 RAS-related protein 80(a)
    (best of 2)
      I(109162-110487)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YPT32(YGL210W)4
    YPT321
    Rab family GTPase, very similar to Ypt31p; involved more4
    Ypt32p1
    57.53(n)1
    62.5(a)1
      7(93792-94460)4
    8526621, 4  NP_011305.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons RABA1e1 RAB GTPase homolog A1E 64.78(n)
    74.23(a)
      827574  NM_117956.2  NP_193578.1 
    rice
    (Oryza sativa)
    Liliopsida D13758.12   -- 78.44(n)    D13758.1 


    ENSEMBL Gene Tree for RAB11B (if available)
    TreeFam Gene Tree for RAB11B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RAB11B gene
    RAB192  RAB39A2  RAB2A2  RAB252  RAB432  RAB142  RAB4B2  RAB39B2  
    RAB11A2  RAB422  RAB4A2  RAB302  RAB4B-EGLN22  RAB2B2  
    18/105 SIMAP similar genes for RAB11B using alignment to 7 protein entries:     RB11B_HUMAN (see all proteins) (see all similar genes):
    RAB11A    RAB43    RAB25    DKFZp686J06205    RAB19    RAB8B
    rab1b    RAB3A    DKFZp686J07132    RAB30    RAB5C    RAB5B
    RAB15    DKFZp313C1541    RAB39B    RAB2A    RAB14    RAB8A

    RAB11B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/392 SNPs in RAB11B are shown (see all 392)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs29139771,2
    C--8389741(-) agcaaA/Gaccct 1 -- us2k10--------
    rs104114351,2
    C,F--8389798(+) gcctcG/Aatttc 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1458435041,2
    --8389824(+) CCTCCC/TGCCTT 1 -- us2k10--------
    rs1491831291,2
    C--8389915(+) TTCTC-/TTTTTT 1 -- us2k10--------
    rs72507261,2
    A--8389924(+) tttttC/Tctttt 1 -- us2k1 trp30--------
    rs1926441541,2
    --8389940(+) TTTTTC/TTTTTT 1 -- us2k10--------
    rs1147638511,2
    F--8389988(+) CTGGTC/GTCTAG 1 -- us2k11Minor allele frequency- G:0.10WA 118
    rs1155401371,2
    F--8389994(+) TCTAGC/GTCCTG 1 -- us2k11Minor allele frequency- G:0.05WA 118
    rs72508701,2
    C,F,A--8390093(+) AGTAAT/CGTATA 1 -- us2k1 tfbs311Minor allele frequency- C:0.48WA NA CSA EA 372
    rs1482477791,2
    C--8390099(+) GTATAC/GTTTGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RAB11B (8454865 - 8469318 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for RAB11B:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv911005CNV Loss21882294
    nsv911004CNV Loss21882294
    nsv911003CNV Loss21882294
    nsv911001CNV Loss21882294
    dgv3719n71CNV Loss21882294
    esv28519CNV Loss19812545

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RAB11B
    DNA2.0 Custom Variant and Variant Library Synthesis for RAB11B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604198    OMIM disorders: --

    4 diseases for RAB11B:    About MalaCards
    cystic fibrosis    hepatocellular carcinoma    tuberculosis    neuronitis


    RAB11B for disorders           About GeneDecksing

    Genetic Association Database (GAD): RAB11B
    Human Genome Epidemiology (HuGE) Navigator: RAB11B (1 document)

    Export disorders for RAB11B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RAB11B gene, integrated from 9 sources (see all 38):
    (articles sorted by number of sources associating them with RAB11B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of two small GTP-binding proteins from human skeletal muscle. (PubMed id 7811277)1, 2, 3, 9 Zhu A.X.... Flier J.S. (1994)
    2. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    3. Common variants at 30 loci contribute to polygenic dyslipidemia. (PubMed id 19060906)1, 4 Kathiresan S....Cupples L.A. (2009)
    4. The crystal structure of the small GTPase Rab11b reveals critical differences relative to the Rab11a isoform. (PubMed id 16545962)1, 2 Scapin S.M....Zanchin N.I. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Identification and characterization of a family of Rab11-interacting proteins. (PubMed id 11495908)1, 2 Hales C.M.... Goldenring J.R. (2001)
    7. VCP phosphorylation-dependent interaction partners pre vent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (2013)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
    10. Acidosis-induced V-ATPase trafficking in salivary duct s is initiated by cAMP/PKA/CREB pathway via regulation of Rab11b expression. (PubMed id 22561749)1 Oehlke O....Roussa E. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9230 HGNC: 9761 AceView: RAB11B Ensembl:ENSG00000185236 euGenes: HUgn9230
    ECgene: RAB11B Kegg: 9230 H-InvDB: RAB11B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RAB11B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAB11B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RAB11B gene:
    Search GeneIP for patents involving RAB11B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for RAB11B  
     OriGene qPCR primer pairs and template standards for RAB11B   OriGene Protein Over-expression Lysate for RAB11B  
     OriGene MassSpec something-or-other for RAB11B   OriGene clones in human, mouse for RAB11B  
     OriGene qSTAR qPCR primer pairs in human, mouse for RAB11B   OriGene Purified Protein for RAB11B  
     OriGene ORF clones in mouse, rat for RAB11B   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RAB11B   OriGene Custom Protein Services for RAB11B  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RAB11B
     QIAGEN SeqTarget long-range PCR primers for resequencing RAB11B
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB11B
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAB11B
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAB11B
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAB11B
     GenScript Custom Purified and Recombinant Proteins Services for RAB11B GenScript cDNA clones with any tag delivered in your preferred vector for RAB11B
     GenScript Custom Assay Services for RAB11B GenScript Custom Superior Antibodies Services for RAB11B
     GenScript Custom overexpressing Cell Line Services for RAB11B CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for RAB11B 

     Regulatory tfbs in RAB11B promoter
     Search Chromatin IP Primers for RAB11B
     RT2 qPCR Primer Assay in human, mouse, rat RAB11B
     GNC Network for RAB11B
     SABiosciences PCR Arrays including human, mouse, rat RAB11B
     Search Tocris compounds for RAB11B (RB11B)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for RAB11B
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     RAB11B antibodies
     RAB11B proteins
     RAB11B lysates
     Antibodies for RAB11B
     See all of Abcam's Antibodies, Kits and Proteins for RAB11B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for RAB11B
     Antibodies for RAB11B
     ELISAs for RAB11B
     CLIAs for RAB11B
     Search LifeMap BioReagents cell lines for RAB11B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB11B
     Browse SwitchGear 3'UTR luciferase reporter plasmids for RAB11B
     SwitchGear Promoter luciferase reporter plasmids for RAB11B
     ThermoFisher Antibody for RAB11B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAB11B
     inGenious Targeting Laboratory - Custom generated mouse model solutions for RAB11B
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RAB11B
    Customized:
     lentivirus for stable overexpression of RAB11B
     lentivirus expression plasmids for stable overexpression of RAB11B
     adenovirus for overexpression of RAB11B
     LSBio Antibodies in human, mouse, rat for RAB11B
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RAB11B gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4