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RAB11B Gene

protein-coding   GIFtS: 60
GCID: GC19P008455

RAB11B, Member RAS Oncogene Family

  Search for RAB11B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RAB11B, Member RAS Oncogene Family1 2
GTP-Binding Protein YPT32 3
H-YPT32
RAB11B, Member Of RAS Oncogene Family2
Ras-Related Protein Rab-11B2
YPT33

External Ids:    HGNC: 97611   Entrez Gene: 92302   Ensembl: ENSG000001852367   OMIM: 6041985   UniProtKB: Q159073   

Export aliases for RAB11B gene to outside databases

Previous GC identifers: GC19P008396 GC19P008546 GC19P008350 GC19P008361 GC19P008108


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RAB11B Gene:
The Ras superfamily of small GTP-binding proteins, which includes the Ras (see MIM 190020), Ral (see MIM 179550),
Rho (see MIM 165390), Rap (see MIM 179520), and Rab (see MIM 179508) families, is involved in controlling a
diverse set of essential cellular functions. The Rab family, including RAB11B, appears to play a critical role in
regulating exocytotic and endocytotic pathways (summary by Zhu et al., 1994 (PubMed 7811277)).(supplied by OMIM,
Nov 2010)

GeneCards Summary for RAB11B Gene:
RAB11B (RAB11B, member RAS oncogene family) is a protein-coding gene. GO annotations related to this gene include GDP binding and GTP binding. An important paralog of this gene is RAB19.

UniProtKB/Swiss-Prot: RB11B_HUMAN, Q15907
Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of
transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active
GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible
for vesicle formation, movement, tethering and fusion. That Rab plays a role in endocytic recycling, regulating
apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance
regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type
calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis.
Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport
in response to extracellular acidosis

Gene Wiki entry for RAB11B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the RAB11B gene promoter:
         AhR   GR   p53   AML1a   Pax-5   GR-beta   p300   Olf-1   GR-alpha   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRAB11B promoter sequence
   Search Chromatin IP Primers for RAB11B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RAB11B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

RAB11B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAB11B gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P008455:  view genomic region     (about GC identifiers)

Start:
8,454,865 bp from pter      End:
8,469,318 bp from pter
Size:
14,454 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RB11B_HUMAN, Q15907 (See protein sequence)
Recommended Name: Ras-related protein Rab-11B precursor  
Size: 218 amino acids; 24489 Da
Subunit: Interacts with KCNMA1 (By similarity). Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 and RAB11FIP4. May
interact with TBC1D14. Interacts with ATP6V1E1
2 PDB 3D structures from and Proteopedia for RAB11B:
2F9L (3D)        2F9M (3D)    
Secondary accessions: A5YM50 B2R7I4 D6W671 Q2YDT2 Q5U0I1 Q6FHR0 Q6FI42 Q8NI07

Explore the universe of human proteins at neXtProt for RAB11B: NX_Q15907

Explore proteomics data for RAB11B at MOPED

Post-translational modifications: 

  • Citrullinated by PADI4 (By similarity)1
  • Ubiquitination2 at Lys24, Lys61, Lys179
  • Modification sites at PhosphoSitePlus

  • See RAB11B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004209.2  
    ENSEMBL proteins: 
     ENSP00000473042   ENSP00000333547   ENSP00000472473   ENSP00000471148  

    RAB11B Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RAB: RAB, member RAS oncogene

    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR003579 Small_GTPase_Rab_type
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q15907

    ProtoNet protein and cluster: Q15907

    1 Blocks protein domain: IPB001806 Transforming protein P21 RAS signature

    UniProtKB/Swiss-Prot: RB11B_HUMAN, Q15907
    Similarity: Belongs to the small GTPase superfamily. Rab family


    Find genes that share domains with RAB11B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RB11B_HUMAN, Q15907
    Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of
    transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active
    GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible
    for vesicle formation, movement, tethering and fusion. That Rab plays a role in endocytic recycling, regulating
    apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance
    regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type
    calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis.
    Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport
    in response to extracellular acidosis
    Induction: Up-regulated by extracellular acidosis and down-regulated by alkalosis (at protein level)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IDA16545962
    GO:0005515protein binding IPI--
    GO:0005525GTP binding IDA16545962
    GO:0019003GDP binding IDA16545962
         
    Find genes that share ontologies with RAB11B           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for RAB11B:
     Decreased cilium length after   Decreased viability after Chla  Decreased viability of wild-ty 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RAB11B
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    hsa-miR-142-5p hsa-miR-495 hsa-miR-1321 hsa-miR-520d-5p hsa-miR-300 hsa-miR-137 hsa-let-7a-2* hsa-miR-340
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RB11B_HUMAN, Q15907: Recycling endosome membrane; Lipid-anchor; Cytoplasmic side (By similarity). Cytoplasmic
    vesicle, secretory vesicle, synaptic vesicle membrane; Lipid-anchor; Cytoplasmic side (By similarity).
    Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side (Probable). Note=Recruited to phagosomes
    containing S.aureus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endosome4
    cytoskeleton3
    cytosol3
    mitochondrion2

    Gene Ontology (GO): Selected cellular component terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion IEA--
    GO:0008021synaptic vesicle ISS--
    GO:0016020membrane ----

    Find genes that share ontologies with RAB11B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RAB11B About    
    See pathways by source

    SuperPathContained pathways About
    1Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions0.36
    2Vasopressin-regulated water reabsorption
    Vasopressin-regulated water reabsorption
    3Remodeling of Adherens Junctions
    Remodeling of Adherens Junctions
    4Endocytosis
    Endocytosis
    5Cytoskeletal Signaling
    Cytoskeletal Signaling


    Find genes that share SuperPaths with RAB11B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RAB11B
        Remodeling of Adherens Junctions
    Epithelial Tight Junctions

    1 Cell Signaling Technology (CST) Pathway for RAB11B
        Cytoskeletal Signaling



    2 Kegg Pathways  (Kegg details for RAB11B):
        Endocytosis
    Vasopressin-regulated water reabsorption

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RAB11B
    Interactions:

        GeneGlobe Interaction Network for RAB11B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RAB11B (Q159071, 3 ENSP000003335474) via UniProtKB, MINT, STRING, and/or I2D (see all 159)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000096150P622693I2D: score=1 
    ENSG00000223367P622693I2D: score=1 
    ENSG00000226225P622693I2D: score=1 
    ENSG00000235650P622693I2D: score=1 
    RPS18P622693I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001881receptor recycling ISS--
    GO:0006184GTP catabolic process IDA16545962
    GO:0006886intracellular protein transport ----
    GO:0006913nucleocytoplasmic transport ----
    GO:0007165signal transduction ----

    Find genes that share ontologies with RAB11B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RAB11B (RB11B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RAB11B gene: 
    NM_004218.3  

    Unigene Cluster for RAB11B:

    RAB11B, member RAS oncogene family
    Hs.626404  [show with all ESTs]
    Unigene Representative Sequence: NM_004218
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000600719 ENST00000328024(uc002mju.4) ENST00000598706 ENST00000601897
    ENST00000594216
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate RAB11B (see all 24):
    hsa-miR-142-5p hsa-miR-495 hsa-miR-1321 hsa-miR-520d-5p hsa-miR-300 hsa-miR-137 hsa-let-7a-2* hsa-miR-340
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    Additional mRNA sequence: 

    AF498947.1 AK225036.1 AK225642.1 AK297498.1 AK310573.1 AK312994.1 BC110081.1 BT019535.1 
    BT019536.1 CR536494.1 CR541691.1 D38516.1 EF560724.1 X79780.1 

    Selected DOTS entries (see all 25):

    DT.100654291  DT.91777995  DT.100643817  DT.432925  DT.121477825  DT.91777990  DT.95176044  DT.100654296 
    DT.91777997  DT.100654281  DT.121477712  DT.100759077  DT.100654282  DT.75146769  DT.121477716  DT.121477754 
    DT.121477755  DT.121477794  DT.91777989  DT.92056983  DT.95176029  DT.95176045  DT.95176047  DT.100683225 

    Selected AceView cDNA sequences (see all 632):

    BQ005686 BF686357 CR597131 BQ427466 CR613165 AF498947 AI433983 CA306413 
    CR590650 BI918142 BU557276 CR624386 CR613277 AI378449 BM984214 BM008534 
    H51752 BE263527 BE270768 BE795972 CR618667 BM699333 BU556850 BQ218591 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RAB11B (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6a · 6b
    SP1:                                                                                -     -               
    SP2:                                                              -                 -     -               
    SP3:        -     -     -     -     -                                                                     
    SP4:                                                                                                      
    SP5:                                            -     -                                                   


    ECgene alternative splicing isoforms for RAB11B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RAB11B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAACTCGGGT
    RAB11B Expression
    About this image

    RAB11B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RAB11B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.626404
        Custom PCR Arrays for RAB11B
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB11B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RAB11B gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rab11b1 , 5 RAB11B, member RAS oncogene family1, 5 91.44(n)1
    99.08(a)1
      17 (17.98 cM)5
    193261  NM_008997.31  NP_033023.11 
     337424845 
    chicken
    (Gallus gallus)
    Aves RAB11B1 RAB11B, member RAS oncogene family 83.18(n)
    98.62(a)
      420063  NM_001012551.1  NP_001012569.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia rab11b-prov2 RAB11B, member RAS oncogene family 79.37(n)    BC041250.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb07g112 Danio rerio cDNA clone MGC55760 IMAGE3816634, complete more 82.34(n)    BC048889.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rab113 endocytosis GTP binding 83(a)   93B13   --
    worm
    (Caenorhabditis elegans)
    Secernentea rab-11.13 RAS-related protein 80(a)
    (best of 2)
      I(109162-110487)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YPT32(YGL210W)4
    YPT321
    Rab family GTPase, very similar to Ypt31p; involved more4
    YPT321
    57.37(n)1
    62.02(a)1
      7(93792-94460)4
    8526621, 4  NP_011305.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons RAB11c1 RAB11c 63.09(n)
    72.2(a)
      837490  NM_100835.2  NP_172434.1 
    rice
    (Oryza sativa)
    Liliopsida D13758.12   -- 78.44(n)    D13758.1 


    ENSEMBL Gene Tree for RAB11B (if available)
    TreeFam Gene Tree for RAB11B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RAB11B gene
    RAB192  RAB39A2  RAB2A2  RAB252  RAB432  RAB142  RAB4B2  RAB39B2  
    RAB11A2  RAB422  RAB4A2  RAB302  RAB4B-EGLN22  RAB2B2  
    Selected SIMAP similar genes for RAB11B using alignment to 4 protein entries:     RB11B_HUMAN (see all proteins) (see all similar genes):
    RAB11A    RAB25    RAB43    RAB19    DKFZp686J06205    RAB8B
    rab1b    RAB30    DKFZp686J07132    RAB2A    RAB5B    DKFZp313C1541
    RAB3A    RAB15    RAB5C    RAB3B    RAB14    RAB39B

    Find genes that share paralogs with RAB11B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RAB11B (see all 392)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs29139771,2
    C--8389741(-) agcaaA/Gaccct 1 -- us2k10--------
    rs104114351,2
    C,F--8389798(+) gcctcG/Aatttc 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1458435041,2
    --8389824(+) CCTCCC/TGCCTT 1 -- us2k10--------
    rs1491831291,2
    C--8389915(+) TTCTC-/TTTTTT 1 -- us2k10--------
    rs72507261,2
    A--8389924(+) tttttC/Tctttt 1 -- us2k1 trp30--------
    rs1926441541,2
    --8389940(+) TTTTTC/TTTTTT 1 -- us2k10--------
    rs1147638511,2
    F--8389988(+) CTGGTC/GTCTAG 1 -- us2k11Minor allele frequency- G:0.10WA 118
    rs1155401371,2
    F--8389994(+) TCTAGC/GTCCTG 1 -- us2k11Minor allele frequency- G:0.05WA 118
    rs72508701,2
    C,F,A--8390093(+) AGTAAT/CGTATA 1 -- us2k1 tfbs311Minor allele frequency- C:0.48WA NA CSA EA 372
    rs1482477791,2
    C--8390099(+) GTATAC/GTTTGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RAB11B (8454865 - 8469318 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for RAB11B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv911005CNV Loss21882294
    nsv911004CNV Loss21882294
    nsv911003CNV Loss21882294
    nsv911001CNV Loss21882294
    dgv3719n71CNV Loss21882294
    esv28519CNV Loss19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RAB11B
    DNA2.0 Custom Variant and Variant Library Synthesis for RAB11B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604198    OMIM disorders: --


    Find genes that share disorders with RAB11B           About GenesLikeMe

    Genetic Association Database (GAD): RAB11B
    Human Genome Epidemiology (HuGE) Navigator: RAB11B (1 document)

    Export disorders for RAB11B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RAB11B gene, integrated from 10 sources (see all 43):
    (articles sorted by number of sources associating them with RAB11B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of two small GTP-binding proteins from human skeletal muscle. (PubMed id 7811277)1, 2, 3, 9 Zhu A.X.... Flier J.S. (Biochem. Biophys. Res. Commun. 1994)
    2. Small GTPase Rab11b regulates degradation of surface membrane L-type Cav1.2 channels. (PubMed id 21248079)1, 2 Best J.M....Kamp T.J. (Am. J. Physiol., Cell Physiol. 2011)
    3. Rab11b and its effector Rip11 regulate the acidosis-induced traffic of V-ATPase in salivary ducts. (PubMed id 20717956)1, 2 Oehlke O....Roussa E. (J. Cell. Physiol. 2011)
    4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    5. Common variants at 30 loci contribute to polygenic dyslipidemia. (PubMed id 19060906)1, 4 Kathiresan S....Cupples L.A. (Nat. Genet. 2009)
    6. Rab11b regulates the apical recycling of the cystic fibrosis transmembrane conductance regulator in polarized intestinal epithelial cells. (PubMed id 19244346)1, 2 Silvis M.R....Bradbury N.A. (Mol. Biol. Cell 2009)
    7. The crystal structure of the small GTPase Rab11b reveals critical differences relative to the Rab11a isoform. (PubMed id 16545962)1, 2 Scapin S.M....Zanchin N.I. (J. Struct. Biol. 2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Divergent functions of neuronal Rab11b in Ca2+-regulated versus constitutive exocytosis. (PubMed id 14627637)1, 2 Khvotchev M.V....SA1dhof T.C. (J. Neurosci. 2003)
    10. Identification and characterization of a family of Rab11-interacting proteins. (PubMed id 11495908)1, 2 Hales C.M.... Goldenring J.R. (J. Biol. Chem. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9230 HGNC: 9761 AceView: RAB11B Ensembl:ENSG00000185236 euGenes: HUgn9230
    ECgene: RAB11B Kegg: 9230 H-InvDB: RAB11B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RAB11B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAB11B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RAB11B gene:
    Search GeneIP for patents involving RAB11B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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