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Aliases for RAB11B Gene

Aliases for RAB11B Gene

  • RAB11B, Member RAS Oncogene Family 2 3 5
  • GTP-Binding Protein YPT3 3 4
  • RAB11B, Member Of RAS Oncogene Family 3
  • Ras-Related Protein Rab-11B 3
  • H-YPT3 3
  • YPT3 4

External Ids for RAB11B Gene

Previous GeneCards Identifiers for RAB11B Gene

  • GC19P008396
  • GC19P008546
  • GC19P008350
  • GC19P008361
  • GC19P008455
  • GC19P008108

Summaries for RAB11B Gene

Entrez Gene Summary for RAB11B Gene

  • The Ras superfamily of small GTP-binding proteins, which includes the Ras (see MIM 190020), Ral (see MIM 179550), Rho (see MIM 165390), Rap (see MIM 179520), and Rab (see MIM 179508) families, is involved in controlling a diverse set of essential cellular functions. The Rab family, including RAB11B, appears to play a critical role in regulating exocytotic and endocytotic pathways (summary by Zhu et al., 1994 [PubMed 7811277]).[supplied by OMIM, Nov 2010]

GeneCards Summary for RAB11B Gene

RAB11B (RAB11B, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB11B include Cystic Fibrosis and Hypotrichosis 3. Among its related pathways are Vasopressin-regulated water reabsorption and Vesicle-mediated transport. GO annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB11A.

UniProtKB/Swiss-Prot for RAB11B Gene

  • The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis.

Gene Wiki entry for RAB11B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB11B Gene

Genomics for RAB11B Gene

Regulatory Elements for RAB11B Gene

Enhancers for RAB11B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G008361 1.6 FANTOM5 ENCODE dbSUPER 13.2 -26.7 -26671 3.4 PKNOX1 ARNT AGO1 ZFP64 ARID4B SIN3A YY1 FOS DEK ZNF263 ZNF177 ZNF699 ELAVL1 RAB11B HNRNPM RAB11B-AS1 ANGPTL4 ZNF558 MARCH2 MIR4999
GH19G008354 1.6 Ensembl ENCODE dbSUPER 12.7 -33.7 -33655 3.1 PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B FEZF1 YY1 FOS SP5 RAB11B MARCH2 RPS28 LOC100129682 ANGPTL4
GH19G008365 1.5 Ensembl ENCODE dbSUPER 13.3 -22.8 -22830 3.1 SIN3A YY1 ZNF121 GLIS2 FOS ZNF263 SP3 REST PPARG ZNF610 RAB11B ENSG00000267510 ANGPTL4 MARCH2 MYO1F MIR4999
GH19G008566 1.4 FANTOM5 ENCODE 1.2 +180.6 180646 7.5 PKNOX1 FOXA2 SIN3A DMAP1 YY1 FOS ZNF548 NFYC JUNB TBX21 MYO1F HNRNPM ZNF699 ZNF558 ELAVL1 ZNF559 XAB2 PRAM1 ENSG00000267986 ZNF426
GH19G008542 0.7 FANTOM5 1.2 +152.4 152431 0.3 ZNF263 KLF1 MAZ KLF17 ZNF398 ZBTB8A ZFHX2 ZBTB48 PATZ1 EGR2 MYO1F PRAM1 RAB11B ENSG00000268618 ZNF414
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RAB11B on UCSC Golden Path with GeneCards custom track

Promoters for RAB11B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000106825 220 1600 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A ZNF2 ZBTB7B YY1 ZNF143

Genomic Location for RAB11B Gene

Chromosome:
19
Start:
8,389,981 bp from pter
End:
8,404,434 bp from pter
Size:
14,454 bases
Orientation:
Plus strand

Genomic View for RAB11B Gene

Genes around RAB11B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB11B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB11B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB11B Gene

Proteins for RAB11B Gene

  • Protein details for RAB11B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15907-RB11B_HUMAN
    Recommended name:
    Ras-related protein Rab-11B
    Protein Accession:
    Q15907
    Secondary Accessions:
    • A5YM50
    • B2R7I4
    • B4DMK0
    • D6W671
    • Q2YDT2
    • Q5U0I1
    • Q6FHR0
    • Q6FI42
    • Q8NI07

    Protein attributes for RAB11B Gene

    Size:
    218 amino acids
    Molecular mass:
    24489 Da
    Quaternary structure:
    • Interacts with KCNMA1 (By similarity). Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 and RAB11FIP4 (PubMed:11495908). May interact with TBC1D14 (PubMed:22613832). Interacts with ATP6V1E1 (PubMed:20717956). Interacts with PI4KB (PubMed:23572552). Interacts (GDP-bound form) with ZFYVE27. Interacts (GDP-bound form) with KIF5A in a ZFYVE27-dependent manner (PubMed:21976701).

    Three dimensional structures from OCA and Proteopedia for RAB11B Gene

    Alternative splice isoforms for RAB11B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAB11B Gene

Post-translational modifications for RAB11B Gene

Other Protein References for RAB11B Gene

No data available for DME Specific Peptides for RAB11B Gene

Domains & Families for RAB11B Gene

Gene Families for RAB11B Gene

Protein Domains for RAB11B Gene

Suggested Antigen Peptide Sequences for RAB11B Gene

Graphical View of Domain Structure for InterPro Entry

Q15907

UniProtKB/Swiss-Prot:

RB11B_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB11B: view

Function for RAB11B Gene

Molecular function for RAB11B Gene

UniProtKB/Swiss-Prot Function:
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis.
UniProtKB/Swiss-Prot Induction:
Up-regulated by extracellular acidosis and down-regulated by alkalosis (at protein level).

Gene Ontology (GO) - Molecular Function for RAB11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IDA 16545962
GO:0005515 protein binding IPI 20717956
GO:0005525 GTP binding IDA 16545962
GO:0019003 GDP binding IDA 16545962
GO:0031489 myosin V binding IPI 24006491
genes like me logo Genes that share ontologies with RAB11B: view
genes like me logo Genes that share phenotypes with RAB11B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB11B Gene

Localization for RAB11B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB11B Gene

Recycling endosome membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Note=Recruited to phagosomes containing S.aureus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB11B gene
Compartment Confidence
extracellular 5
cytosol 5
endosome 4
cytoskeleton 3
mitochondrion 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for RAB11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005768 endosome IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RAB11B: view

Pathways & Interactions for RAB11B Gene

genes like me logo Genes that share pathways with RAB11B: view

Pathways by source for RAB11B Gene

Gene Ontology (GO) - Biological Process for RAB11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001881 receptor recycling ISS --
GO:0006810 transport IEA --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0015031 protein transport IEA --
GO:0032402 melanosome transport IBA,ISS --
genes like me logo Genes that share ontologies with RAB11B: view

No data available for SIGNOR curated interactions for RAB11B Gene

Transcripts for RAB11B Gene

Unigene Clusters for RAB11B Gene

RAB11B, member RAS oncogene family:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB11B Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6a · 6b
SP1: - -
SP2: - - -
SP3: - - - - -
SP4:
SP5: - -
SP6: - -

Relevant External Links for RAB11B Gene

GeneLoc Exon Structure for
RAB11B
ECgene alternative splicing isoforms for
RAB11B

Expression for RAB11B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAB11B Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RAB11B Gene



Protein tissue co-expression partners for RAB11B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RAB11B Gene:

RAB11B

SOURCE GeneReport for Unigene cluster for RAB11B Gene:

Hs.626404

Evidence on tissue expression from TISSUES for RAB11B Gene

  • Nervous system(4.9)
  • Muscle(4.5)
  • Lung(3.9)
  • Intestine(3.2)
  • Eye(3.1)
  • Lymph node(2.7)
  • Kidney(2.4)
  • Liver(2)
genes like me logo Genes that share expression patterns with RAB11B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAB11B Gene

Orthologs for RAB11B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RAB11B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB11A 35
  • 100 (a)
OneToOne
RAB11B 34
  • 99.69 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 99 (a)
OneToMany
-- 35
  • 85 (a)
OneToMany
dog
(Canis familiaris)
Mammalia RAB11B 34 35
  • 94.8 (n)
cow
(Bos Taurus)
Mammalia RAB11B 34 35
  • 94.5 (n)
mouse
(Mus musculus)
Mammalia Rab11b 34 16 35
  • 91.44 (n)
rat
(Rattus norvegicus)
Mammalia Rab11b 34
  • 90.37 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RAB11B 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAB11B 34 35
  • 83.18 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia rab11b.1 34
  • 79.51 (n)
Str.6859 34
African clawed frog
(Xenopus laevis)
Amphibia rab11b-prov 34
zebrafish
(Danio rerio)
Actinopterygii rab11ba 35
  • 96 (a)
OneToOne
LOC100536606 34
  • 84.25 (n)
wufb07g11 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10241 34
fruit fly
(Drosophila melanogaster)
Insecta Rab11 36 35
  • 83 (a)
worm
(Caenorhabditis elegans)
Secernentea rab-11.1 36 35
  • 80 (a)
rab-11.2 35
  • 68 (a)
ManyToMany
F11A5.3 36
  • 51 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPT31 35
  • 59 (a)
ManyToMany
YPT32 34 35 37
  • 57.37 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons RAB11c 34
  • 63.09 (n)
soybean
(Glycine max)
eudicotyledons Gma.1450 34
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.335 34
rice
(Oryza sativa)
Liliopsida Os05g0105100 34
  • 67.91 (n)
barley
(Hordeum vulgare)
Liliopsida Hv.9485 34
wheat
(Triticum aestivum)
Liliopsida Ta.8775 34
Species where no ortholog for RAB11B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RAB11B Gene

ENSEMBL:
Gene Tree for RAB11B (if available)
TreeFam:
Gene Tree for RAB11B (if available)

Paralogs for RAB11B Gene

genes like me logo Genes that share paralogs with RAB11B: view

Variants for RAB11B Gene

Sequence variations from dbSNP and Humsavar for RAB11B Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000080334 -- 8,390,701(+) CCAGA(A/G)CCTAG intron-variant, upstream-variant-2KB
rs1000346951 -- 8,389,922(+) CCCGG(A/T)AATGG intron-variant, upstream-variant-2KB
rs1000392208 -- 8,403,734(+) TGCCC(A/G)GGGAA utr-variant-3-prime
rs1000462076 -- 8,400,746(+) CATAC(C/T)AGGCT intron-variant
rs1000553048 -- 8,394,741(+) CCTGG(C/G)CAACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB11B Gene

Variant ID Type Subtype PubMed ID
dgv6257n54 CNV gain 21841781
esv28519 CNV loss 19812545
esv3643614 CNV gain 21293372
nsv578558 CNV loss 21841781

Variation tolerance for RAB11B Gene

Residual Variation Intolerance Score: 29.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.21; 4.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAB11B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAB11B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB11B Gene

Disorders for RAB11B Gene

MalaCards: The human disease database

(3) MalaCards diseases for RAB11B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
cystic fibrosis
  • pseudomonas aeruginosa chronic infection by, in cystic fibrosis
hypotrichosis 3
  • htss2
rectum adenocarcinoma
  • adenocarcinoma of rectum
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for RAB11B

Genetic Association Database (GAD)
RAB11B
Human Genome Epidemiology (HuGE) Navigator
RAB11B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAB11B
genes like me logo Genes that share disorders with RAB11B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RAB11B Gene

Publications for RAB11B Gene

  1. Molecular cloning of two small GTP-binding proteins from human skeletal muscle. (PMID: 7811277) Zhu A.X. … Flier J.S. (Biochem. Biophys. Res. Commun. 1994) 2 3 4 22 64
  2. ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding. (PMID: 23572552) Greninger A.L. … DeRisi J.L. (MBio 2013) 3 4 64
  3. TBC1D14 regulates autophagosome formation via Rab11- and ULK1- positive recycling endosomes. (PMID: 22613832) Longatti A. … Tooze S.A. (J. Cell Biol. 2012) 3 4 64
  4. Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes. (PMID: 21255211) Seto S. … Koide Y. (Traffic 2011) 3 4 64
  5. Rab11b and its effector Rip11 regulate the acidosis-induced traffic of V-ATPase in salivary ducts. (PMID: 20717956) Oehlke O. … Roussa E. (J. Cell. Physiol. 2011) 3 4 64

Products for RAB11B Gene

Sources for RAB11B Gene

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