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Aliases for RAB11B Gene

Aliases for RAB11B Gene

  • RAB11B, Member RAS Oncogene Family 2 3
  • GTP-Binding Protein YPT3 3 4
  • RAB11B, Member Of RAS Oncogene Family 3
  • Ras-Related Protein Rab-11B 3
  • H-YPT3 3
  • YPT3 4

External Ids for RAB11B Gene

Previous GeneCards Identifiers for RAB11B Gene

  • GC19P008396
  • GC19P008546
  • GC19P008350
  • GC19P008361
  • GC19P008455
  • GC19P008108

Summaries for RAB11B Gene

Entrez Gene Summary for RAB11B Gene

  • The Ras superfamily of small GTP-binding proteins, which includes the Ras (see MIM 190020), Ral (see MIM 179550), Rho (see MIM 165390), Rap (see MIM 179520), and Rab (see MIM 179508) families, is involved in controlling a diverse set of essential cellular functions. The Rab family, including RAB11B, appears to play a critical role in regulating exocytotic and endocytotic pathways (summary by Zhu et al., 1994 [PubMed 7811277]).[supplied by OMIM, Nov 2010]

GeneCards Summary for RAB11B Gene

RAB11B (RAB11B, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Endocytosis and Cytoskeletal Signaling. GO annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB42.

UniProtKB/Swiss-Prot for RAB11B Gene

  • The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis.

Gene Wiki entry for RAB11B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB11B Gene

Genomics for RAB11B Gene

Regulatory Elements for RAB11B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RAB11B Gene

Start:
8,389,981 bp from pter
End:
8,404,434 bp from pter
Size:
14,454 bases
Orientation:
Plus strand

Genomic View for RAB11B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAB11B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB11B Gene

Proteins for RAB11B Gene

  • Protein details for RAB11B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15907-RB11B_HUMAN
    Recommended name:
    Ras-related protein Rab-11B
    Protein Accession:
    Q15907
    Secondary Accessions:
    • A5YM50
    • B2R7I4
    • B4DMK0
    • D6W671
    • Q2YDT2
    • Q5U0I1
    • Q6FHR0
    • Q6FI42
    • Q8NI07

    Protein attributes for RAB11B Gene

    Size:
    218 amino acids
    Molecular mass:
    24489 Da
    Quaternary structure:
    • Interacts with KCNMA1 (By similarity). Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 and RAB11FIP4. May interact with TBC1D14. Interacts with ATP6V1E1.

    Three dimensional structures from OCA and Proteopedia for RAB11B Gene

    Alternative splice isoforms for RAB11B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAB11B Gene

Proteomics data for RAB11B Gene at MOPED

Post-translational modifications for RAB11B Gene

Other Protein References for RAB11B Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RAB11B (RAB11B)

No data available for DME Specific Peptides for RAB11B Gene

Domains for RAB11B Gene

Gene Families for RAB11B Gene

HGNC:
  • RAB :RAB, member RAS oncogene

Suggested Antigen Peptide Sequences for RAB11B Gene

Graphical View of Domain Structure for InterPro Entry

Q15907

UniProtKB/Swiss-Prot:

RB11B_HUMAN :
  • Q15907
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB11B: view

Function for RAB11B Gene

Molecular function for RAB11B Gene

UniProtKB/Swiss-Prot Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis.
UniProtKB/Swiss-Prot Induction: Up-regulated by extracellular acidosis and down-regulated by alkalosis (at protein level).

Gene Ontology (GO) - Molecular Function for RAB11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IDA 16545962
GO:0005515 protein binding IPI 20717956
GO:0005525 GTP binding IDA 16545962
GO:0019003 GDP binding IDA 16545962
GO:0031489 myosin V binding IPI 24006491
genes like me logo Genes that share ontologies with RAB11B: view
genes like me logo Genes that share phenotypes with RAB11B: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RAB11B Gene

Localization for RAB11B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB11B Gene

Recycling endosome membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Note=Recruited to phagosomes containing S.aureus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB11B Gene COMPARTMENTS Subcellular localization image for RAB11B gene
Compartment Confidence
plasma membrane 5
endosome 4
cytoskeleton 3
cytosol 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for RAB11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm --
GO:0005739 mitochondrion IEA --
GO:0008021 synaptic vesicle ISS --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with RAB11B: view

Pathways for RAB11B Gene

genes like me logo Genes that share pathways with RAB11B: view

Pathways by source for RAB11B Gene

1 Cell Signaling Technology pathway for RAB11B Gene
2 KEGG pathways for RAB11B Gene

Gene Ontology (GO) - Biological Process for RAB11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001881 receptor recycling ISS --
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport IBA --
GO:0006913 nucleocytoplasmic transport --
GO:0007165 signal transduction --
genes like me logo Genes that share ontologies with RAB11B: view

Transcripts for RAB11B Gene

Unigene Clusters for RAB11B Gene

RAB11B, member RAS oncogene family:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAB11B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB11B Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6a · 6b
SP1: - -
SP2: - - -
SP3: - - - - -
SP4:
SP5: - -
SP6: - -

Relevant External Links for RAB11B Gene

GeneLoc Exon Structure for
RAB11B
ECgene alternative splicing isoforms for
RAB11B

Expression for RAB11B Gene

mRNA expression in normal human tissues for RAB11B Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB11B Gene

SOURCE GeneReport for Unigene cluster for RAB11B Gene Hs.626404

genes like me logo Genes that share expressions with RAB11B: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RAB11B Gene

Orthologs for RAB11B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RAB11B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB11A 36
  • 100 (a)
OneToOne
RAB11B 35
  • 99.69 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia RAB11B 35
  • 94.5 (n)
  • 100 (a)
RAB11B 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAB11B 35
  • 94.8 (n)
  • 100 (a)
RAB11B 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rab11b 35
  • 91.44 (n)
  • 99.08 (a)
Rab11b 16
Rab11b 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 99 (a)
OneToMany
-- 36
  • 85 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia RAB11B 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rab11b 35
  • 90.37 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves RAB11B 35
  • 83.18 (n)
  • 98.62 (a)
RAB11B 36
  • 99 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia rab11b-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rab11b.1 35
  • 79.51 (n)
  • 97.71 (a)
Str.6859 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10241 35
zebrafish
(Danio rerio)
Actinopterygii LOC100536606 35
  • 84.25 (n)
  • 96.79 (a)
rab11ba 36
  • 96 (a)
OneToOne
wufb07g11 35
fruit fly
(Drosophila melanogaster)
Insecta Rab11 36
  • 85 (a)
OneToMany
Rab11 37
  • 83 (a)
worm
(Caenorhabditis elegans)
Secernentea rab-11.1 36
  • 81 (a)
ManyToMany
rab-11.2 36
  • 68 (a)
ManyToMany
rab-11.1 37
  • 80 (a)
F11A5.3 37
  • 51 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPT31 36
  • 59 (a)
ManyToMany
YPT32 35
  • 57.37 (n)
  • 62.02 (a)
YPT32 36
  • 60 (a)
ManyToMany
YPT32 38
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.335 35
soybean
(Glycine max)
eudicotyledons Gma.1450 35
thale cress
(Arabidopsis thaliana)
eudicotyledons RAB11c 35
  • 63.09 (n)
  • 72.2 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.9485 35
rice
(Oryza sativa)
Liliopsida Os05g0105100 35
  • 67.91 (n)
  • 67.76 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.8775 35
Species with no ortholog for RAB11B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RAB11B Gene

ENSEMBL:
Gene Tree for RAB11B (if available)
TreeFam:
Gene Tree for RAB11B (if available)

Paralogs for RAB11B Gene

genes like me logo Genes that share paralogs with RAB11B: view

Variants for RAB11B Gene

Sequence variations from dbSNP and Humsavar for RAB11B Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs754671 -- 8,394,076(-) CTGGG(A/G)ATGAA intron-variant
rs890857 -- 8,399,993(+) GACGG(C/T)AAGAC reference, synonymous-codon
rs890858 -- 8,394,156(-) GCCCA(A/G)CCAGT intron-variant
rs2230875 -- 8,402,107(+) GTGGG(C/T)GCCCT reference, synonymous-codon
rs2230876 -- 8,403,453(+) GACCG(C/T)GCTGC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for RAB11B Gene

Variant ID Type Subtype PubMed ID
dgv3719n71 CNV Loss 21882294
nsv911001 CNV Loss 21882294
nsv911003 CNV Loss 21882294
nsv911004 CNV Loss 21882294
esv28519 CNV Loss 19812545
nsv911005 CNV Loss 21882294

Relevant External Links for RAB11B Gene

HapMap Linkage Disequilibrium report
RAB11B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB11B Gene

Disorders for RAB11B Gene

Relevant External Links for RAB11B

Genetic Association Database (GAD)
RAB11B
Human Genome Epidemiology (HuGE) Navigator
RAB11B
genes like me logo Genes that share disorders with RAB11B: view

No data available for UniProtKB/Swiss-Prot for RAB11B Gene

Publications for RAB11B Gene

  1. Molecular cloning of two small GTP-binding proteins from human skeletal muscle. (PMID: 7811277) Zhu A.X. … Flier J.S. (Biochem. Biophys. Res. Commun. 1994) 2 3 4 23
  2. Identification and characterization of a family of Rab11-interacting proteins. (PMID: 11495908) Hales C.M. … Goldenring J.R. (J. Biol. Chem. 2001) 3 4
  3. Divergent functions of neuronal Rab11b in Ca2+-regulated versus constitutive exocytosis. (PMID: 14627637) Khvotchev M.V. … SA1dhof T.C. (J. Neurosci. 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Common variants at 30 loci contribute to polygenic dyslipidemia. (PMID: 19060906) Kathiresan S. … Cupples L.A. (Nat. Genet. 2009) 3 48

Products for RAB11B Gene

Sources for RAB11B Gene

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