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Aliases for RAB11B Gene

Aliases for RAB11B Gene

  • RAB11B, Member RAS Oncogene Family 2 3 5
  • GTP-Binding Protein YPT3 3 4
  • RAB11B, Member Of RAS Oncogene Family 3
  • H-YPT3 3
  • YPT3 4

External Ids for RAB11B Gene

Previous GeneCards Identifiers for RAB11B Gene

  • GC19P008396
  • GC19P008546
  • GC19P008350
  • GC19P008361
  • GC19P008455
  • GC19P008108

Summaries for RAB11B Gene

Entrez Gene Summary for RAB11B Gene

  • The Ras superfamily of small GTP-binding proteins, which includes the Ras (see MIM 190020), Ral (see MIM 179550), Rho (see MIM 165390), Rap (see MIM 179520), and Rab (see MIM 179508) families, is involved in controlling a diverse set of essential cellular functions. The Rab family, including RAB11B, appears to play a critical role in regulating exocytotic and endocytotic pathways (summary by Zhu et al., 1994 [PubMed 7811277]).[supplied by OMIM, Nov 2010]

GeneCards Summary for RAB11B Gene

RAB11B (RAB11B, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB11B include Cystic Fibrosis. Among its related pathways are Remodeling of Adherens Junctions and Vasopressin-regulated water reabsorption. GO annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB39A.

UniProtKB/Swiss-Prot for RAB11B Gene

  • The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis.

Gene Wiki entry for RAB11B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB11B Gene

Genomics for RAB11B Gene

Regulatory Elements for RAB11B Gene

Enhancers for RAB11B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RAB11B on UCSC Golden Path with GeneCards custom track

Promoters for RAB11B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RAB11B on UCSC Golden Path with GeneCards custom track

Genomic Location for RAB11B Gene

Chromosome:
19
Start:
8,389,981 bp from pter
End:
8,404,434 bp from pter
Size:
14,454 bases
Orientation:
Plus strand

Genomic View for RAB11B Gene

Genes around RAB11B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB11B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB11B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB11B Gene

Proteins for RAB11B Gene

  • Protein details for RAB11B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15907-RB11B_HUMAN
    Recommended name:
    Ras-related protein Rab-11B
    Protein Accession:
    Q15907
    Secondary Accessions:
    • A5YM50
    • B2R7I4
    • B4DMK0
    • D6W671
    • Q2YDT2
    • Q5U0I1
    • Q6FHR0
    • Q6FI42
    • Q8NI07

    Protein attributes for RAB11B Gene

    Size:
    218 amino acids
    Molecular mass:
    24489 Da
    Quaternary structure:
    • Interacts with KCNMA1 (By similarity). Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 and RAB11FIP4. May interact with TBC1D14. Interacts with ATP6V1E1.

    Three dimensional structures from OCA and Proteopedia for RAB11B Gene

    Alternative splice isoforms for RAB11B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAB11B Gene

Proteomics data for RAB11B Gene at MOPED

Post-translational modifications for RAB11B Gene

Other Protein References for RAB11B Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RAB11B (RAB11B)

No data available for DME Specific Peptides for RAB11B Gene

Domains & Families for RAB11B Gene

Gene Families for RAB11B Gene

Suggested Antigen Peptide Sequences for RAB11B Gene

Graphical View of Domain Structure for InterPro Entry

Q15907

UniProtKB/Swiss-Prot:

RB11B_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB11B: view

Function for RAB11B Gene

Molecular function for RAB11B Gene

UniProtKB/Swiss-Prot Function:
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis.
UniProtKB/Swiss-Prot Induction:
Up-regulated by extracellular acidosis and down-regulated by alkalosis (at protein level).
genes like me logo Genes that share phenotypes with RAB11B: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB11B Gene

Localization for RAB11B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB11B Gene

Recycling endosome membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Note=Recruited to phagosomes containing S.aureus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB11B Gene COMPARTMENTS Subcellular localization image for RAB11B gene
Compartment Confidence
cytoskeleton 5
extracellular 5
endosome 4
plasma membrane 4
cytosol 3
mitochondrion 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for RAB11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005815 microtubule organizing center IDA --
GO:0008021 synaptic vesicle ISS --
GO:0016023 cytoplasmic, membrane-bounded vesicle IEA --
GO:0030054 cell junction IDA --
genes like me logo Genes that share ontologies with RAB11B: view

Pathways & Interactions for RAB11B Gene

genes like me logo Genes that share pathways with RAB11B: view

Pathways by source for RAB11B Gene

1 Cell Signaling Technology pathway for RAB11B Gene

Gene Ontology (GO) - Biological Process for RAB11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001881 receptor recycling ISS --
GO:0006886 intracellular protein transport IEA --
GO:0007165 signal transduction IEA --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0035773 insulin secretion involved in cellular response to glucose stimulus ISS --
genes like me logo Genes that share ontologies with RAB11B: view

No data available for SIGNOR curated interactions for RAB11B Gene

Drugs & Compounds for RAB11B Gene

No Compound Related Data Available

Transcripts for RAB11B Gene

Unigene Clusters for RAB11B Gene

RAB11B, member RAS oncogene family:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAB11B Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6a · 6b
SP1: - -
SP2: - - -
SP3: - - - - -
SP4:
SP5: - -
SP6: - -

Relevant External Links for RAB11B Gene

GeneLoc Exon Structure for
RAB11B
ECgene alternative splicing isoforms for
RAB11B

Expression for RAB11B Gene

mRNA expression in normal human tissues for RAB11B Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB11B Gene



SOURCE GeneReport for Unigene cluster for RAB11B Gene Hs.626404

genes like me logo Genes that share expression patterns with RAB11B: view

Protein tissue co-expression partners for RAB11B Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RAB11B Gene

Orthologs for RAB11B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RAB11B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RAB11B 35
  • 94.5 (n)
  • 100 (a)
RAB11B 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAB11B 35
  • 94.8 (n)
  • 100 (a)
RAB11B 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rab11b 35
  • 91.44 (n)
  • 99.08 (a)
Rab11b 16
Rab11b 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RAB11B 35
  • 99.69 (n)
  • 100 (a)
RAB11A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rab11b 35
  • 90.37 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 99 (a)
OneToMany
-- 36
  • 85 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia RAB11B 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAB11B 35
  • 83.18 (n)
  • 98.62 (a)
RAB11B 36
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rab11b.1 35
  • 79.51 (n)
  • 97.71 (a)
Str.6859 35
African clawed frog
(Xenopus laevis)
Amphibia rab11b-prov 35
zebrafish
(Danio rerio)
Actinopterygii LOC100536606 35
  • 84.25 (n)
  • 96.79 (a)
wufb07g11 35
rab11ba 36
  • 96 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10241 35
fruit fly
(Drosophila melanogaster)
Insecta Rab11 37
  • 83 (a)
Rab11 36
  • 85 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F11A5.3 37
  • 51 (a)
rab-11.1 37
  • 80 (a)
rab-11.1 36
  • 81 (a)
ManyToMany
rab-11.2 36
  • 68 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPT32 35
  • 57.37 (n)
  • 62.02 (a)
YPT31 36
  • 59 (a)
ManyToMany
YPT32 36
  • 60 (a)
ManyToMany
YPT32 38
thale cress
(Arabidopsis thaliana)
eudicotyledons RAB11c 35
  • 63.09 (n)
  • 72.2 (a)
soybean
(Glycine max)
eudicotyledons Gma.1450 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.335 35
barley
(Hordeum vulgare)
Liliopsida Hv.9485 35
rice
(Oryza sativa)
Liliopsida Os05g0105100 35
  • 67.91 (n)
  • 67.76 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.8775 35
Species with no ortholog for RAB11B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RAB11B Gene

ENSEMBL:
Gene Tree for RAB11B (if available)
TreeFam:
Gene Tree for RAB11B (if available)

Paralogs for RAB11B Gene

genes like me logo Genes that share paralogs with RAB11B: view

Variants for RAB11B Gene

Sequence variations from dbSNP and Humsavar for RAB11B Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs7260302 -- 8,401,674(+) gccac(C/G)acccc intron-variant
rs7260496 -- 8,399,561(+) ATCTC(A/G)AGCTG intron-variant
rs12976739 -- 8,396,779(+) CCTGC(A/G)GAAGG intron-variant
rs7409035 -- 8,398,747(+) ACAAC(C/G/T)GTGAC intron-variant
rs7409109 -- 8,398,939(+) cgccc(A/G)gctaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB11B Gene

Variant ID Type Subtype PubMed ID
dgv3719n71 CNV Loss 21882294
nsv911001 CNV Loss 21882294
nsv911003 CNV Loss 21882294
nsv911004 CNV Loss 21882294
esv28519 CNV Loss 19812545
nsv911005 CNV Loss 21882294

Variation tolerance for RAB11B Gene

Residual Variation Intolerance Score: 29.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.21; 4.65% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RAB11B Gene

Disorders for RAB11B Gene

MalaCards: The human disease database

(1) MalaCards diseases for RAB11B Gene - From: GeneCards

Disorder Aliases PubMed IDs
cystic fibrosis
  • pseudomonas aeruginosa chronic infection by, in cystic fibrosis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for RAB11B

Genetic Association Database (GAD)
RAB11B
Human Genome Epidemiology (HuGE) Navigator
RAB11B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAB11B
genes like me logo Genes that share disorders with RAB11B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RAB11B Gene

Publications for RAB11B Gene

  1. Molecular cloning of two small GTP-binding proteins from human skeletal muscle. (PMID: 7811277) Zhu A.X. … Flier J.S. (Biochem. Biophys. Res. Commun. 1994) 2 3 4 23 67
  2. New host factors important for respiratory syncytial virus (RSV) replication revealed by a novel microfluidics screen for interactors of matrix (M) protein. (PMID: 25556234) Kipper S. … Bajorek M. (Mol. Cell Proteomics 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. The Parkinson's Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through the Endosomal Pathway. (PMID: 26355680) Imai Y. … Takahashi R. (PLoS Genet. 2015) 3

Products for RAB11B Gene

Sources for RAB11B Gene

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