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RAB11B Gene

protein-coding   GIFtS: 59

GC19P008361
RAB11B, member RAS oncogene family
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
H-YPT3 1, 2
MGC133246 2
YPT3 3
Descriptions
GTP-binding protein YPT3 3
RAB11B, member RAS oncogene family 2
RAB11B, member of RAS oncogene family 2
External Ids
HGNC: 97611
Entrez Gene: 92302
UniProtKB: Q159073
Ensembl: ENSG000001852367
Search outside databases for aliases for RAB11B gene

Previous GC identifers: GC19P008396 GC19P008546 GC19P008350

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: RB11B_HUMAN, Q15907
Function: Possesses GTPase activity

Gene Wiki entry for RAB11B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the RAB11B gene  

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

RAB11B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P008361:     (about GC identifiers)

Start:
8,361,296 bp from pter
End:
8,375,318 bp from pter
Size:
14,023 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000019.8  NT_077812.2  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: RB11B_HUMAN, Q15907 (See protein sequence)
Recommended Name: Ras-related protein Rab-11B  
Size: 218 amino acids; 24489 Da
Subunit: Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 and RAB11FIP4
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
PDB structure from and Proteopedia :
2F9L (3D)    2F9M (3D)    
Secondary accessions: B2R7I4 Q2YDT2 Q8NI07

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_004209.2  

    ENSEMBL proteins: 
    ENSP00000333547 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Sigma-Aldrich AQUA Peptides for RAB11B  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (Rab11)
    Human Recombinant Proteins from Abnova (RAB11B)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886 plasma membrane IEA--
    GO:0016023 cytoplasmic membrane-bounded vesicle IEA--
    About this table

    Antibodies for RAB11B: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for RAB11B
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for RAB11B 
    Antibodies from Abcam (Rab11), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (RAB11B)
    Novus Biologicals Antibodies for RAB11B

    Assays for RAB11B: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5 InterPro domains/families:
     IPR015595 Rab11
     IPR001806 Ras_GTPase
     IPR005225 Small_GTP_bd
     IPR003579 GTPase_Rab
     IPR013753 Ras


       GeneDecks  RAB11B for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q15907

    ProtoNet protein and cluster: Q15907

    1 Blocks protein family: IPB001806 Transforming protein P21 RAS signature

    UniProtKB/Swiss-Prot: RB11B_HUMAN, Q15907
    Similarity: Belongs to the small GTPase superfamily. Rab family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (RAB11B)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (RAB11B)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004218

                  Applied Biosystems Silencer® siRNAs for RAB11B

                  Sigma-Aldrich siRNA for RAB11B  
                         Sigma-Aldrich shRNA for RAB11B  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for RAB11B
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_004218
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_004218
                                     untagged cDNA clone in CMV expression vector: NM_004218 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_004218

    UniProtKB/Swiss-Prot: RB11B_HUMAN, Q15907
    Function: Possesses GTPase activity

    3 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0003924 GTPase activity TAS7811277
    GO:0005525 GTP binding IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    2 Sigma-Aldrich "Your Favorite Gene" Pathways for  RAB11B  (Your Favorite Gene powered by Ingenuity) 
     Clathrin-mediated Endocytosis
     Fc&gamma

       GeneDecks  RAB11B for the pathways selected above  
    About GeneDecksing

     Gene Network CentralTM Interacting Genes and Proteins Network for  RAB11B 


    1 Interacting protein for RAB11B (ENSP000003335473) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    --ENSP000003741803STRING (score=.882)
    About this table

    2 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007264 small GTPase mediated signal transduction IEA--
    GO:0015031 protein transport IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for RAB11B

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (RAB11B)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (RAB11B)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004218

                  Sigma-Aldrich siRNA for RAB11B  
                         Sigma-Aldrich shRNA for RAB11B  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_004218  

    REFSEQ mRNAs for RAB11B gene: 

    NM_004218.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_004218  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_004218
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_004218
                                     untagged cDNA clone in CMV expression vector: NM_004218 

    Additional cDNA sequence: 

    AF498947.1 AK225036.1 AK225642.1 AK297498.1 AK310573.1 AK312994.1 BC110081.1 BT019535.1 
    BT019536.1 CR536494.1 CR541691.1 CR590650.1 CR592057.1 CR592281.1 CR593189.1 CR593323.1 
    CR593439.1 CR594452.1 CR596517.1 CR597131.1 CR600179.1 CR600800.1 CR605393.1 CR606224.1 
    CR606883.1 CR609776.1 CR613165.1 CR613277.1 CR615157.1 CR618647.1 CR618667.1 CR620665.1 
    CR621845.1 CR624386.1 CR625102.1 CR626143.1 CR626645.1 D38516.1 EF560724.1 X79780.1 

    24/27 DOTS entries (see all 27 ):

    DT.100654291  DT.91777995  DT.100643817  DT.432925  DT.121477825  DT.91777990  DT.95176044  DT.100654296 
    DT.100746160  DT.91777997  DT.100654281  DT.121477712  DT.100759077  DT.75101305  DT.100654282  DT.75146769 
    DT.121477716  DT.121477754  DT.121477755  DT.121477794  DT.91777989  DT.92056983  DT.95176029  DT.95176047 

    24/632 AceView cDNA sequences (see all 632 ):

    BU754446 BU728778 AA687467 CR594452 BU735141 BM543168 CR613277 BM801322 
    BQ682487 AW160512 CR592281 BI488603 BU855688 BE263527 BG151535 BQ881881 
    CA430893 AI378449 BE732553 AI718910 BU508476 BU735248 BP362865 CR609776 

    highest scoring ESTs for RAB11B:

    X79780 AF498947 AL525058 AL551873 AW651764 AW732313 BE254888 BE256796 BE263748 BE535311 

    Unigene Cluster for RAB11B:

    RAB11B, member RAS oncogene family
    Hs.626404  [show with all ESTs]
    Unigene Representative Sequence: NM_004218


    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for RAB11B (see all 6 )

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6a · 6b
    SP1:                                                                                -     -               
    SP2:                                                              -                 -     -               
    SP3:        -     -     -     -     -                                                                     
    SP4:                                                                                                      
    SP5:                                            -     -                                                   

    About this scheme

    ECgene alternative splicing isoforms for RAB11B

    1 Ensembl transcript including schematic representation:
    ENST00000328024  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    RAB11B expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for RAB11B

    1 / 2 / 3

    8 probe-sets matching RAB11B gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    45751_g_at2, 3 U95-B 1 1.00 1.00 -0.30 1.49 AA528592 0.20 1.00 0.72 1
    34478_at2, 3 U133-A 1 1.00 1.00 0.81 0.73 X79780 1.00 1.00 1.00 1
    65851_at2, 3 U95-C 1 0.31 1.00 0.65 0.79 AA522528 0.60 1.00 0.82 1

    45750_at*2, 3 U95-B 1 -- -- 0.10 0.16 AA528592 0.20 1.00 0.72 1

    217793_at2, 3 U133-A 1 1.00 1.00 -- -- AL575337 0.60 1.00 0.82 1
    34478_at2, 3 U133-A 1 1.00 1.00 -- -- X79780 1.00 1.00 1.00 1

    217793_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    34478_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  RAB11B for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: AAACTCGGGT

    SOURCE GeneReport for Unigene cluster: Hs.626404

    Expression variation in blood from EXPOLDB for RAB11B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for RAB11B gene from 5/21 species (see all 21 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    RAB11B1   -- RAB11B, member RAS oncogene family 93.3(n)
    98.09(a)
    611619  XM_849306.1  XP_854399.1 
    chimpanzee
    (Pan troglodytes)
    RAB11B1   -- RAB11B, member RAS oncogene family 99.24(n)
    99.54(a)
    743711  XM_001147785.1  XP_001147785.1 
    cow
    (Bos taurus)
    RAB11B1   -- RAB11B, member RAS oncogene family 94.04(n)
    99.54(a)
    532723  NM_001035391.1  NP_001030468.1 
    rat
    (Rattus norvegicus)
    Rab11b1   -- RAB11B, member RAS oncogene family 89.91(n)
    99.54(a)
    79434  NM_032617.2  NP_116006.1 
    mouse
    (Mus musculus)
    Rab11b1, 5 17 (18.30 cM)5
    RAB11B, member RAS oncogene family1, 5 90.98(n)1
    98.62(a)1
    193261  NM_008997.31  NP_033023.11 
     AA7638615  AB2326065  (see all 38)
    About this table        Species with no ortholog for RAB11B

    ENSEMBL Gene Tree for RAB11B
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for RAB11B gene
    RAB352  RAB252  RAB11A2  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/110 NCBI SNPs in RAB11B are shown (see all 110 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 40)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 19 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs72548821,2
    A,C,F,H8359822(+) CCATGC/TGTGGT 1 -- ng516Minor allele frequency- T:0.46EU WA EA NA 438
    rs22415881,2
    C,F8374485(+) GCCCGC/TCCCCG 1 -- ut31 ese32Minor allele frequency- T:0.49EA MN 1494
    --
    rs66030661,2
    C,F8374800(+) CCCTCT/CGTGAC 1 -- ut31 trp33Minor allele frequency- C:0.01NA 140
    --
    rs72508701,2
    A,C8359682(+) AGTAAC/TGTATA 1 -- ng51 tfbs30--------
    --
    rs115563191,2
    C,H8373097(+) TGCTGG/CTGGGC 1 L/V mis18Minor allele frequency- C:0.00EU EA WA 812
    rs129851451,2
    H8375043(+) cctctC/Gggccc 1 -- ut31 ese34Minor allele frequency- G:0.00EU EA WA 420
    --
    rs72507261,2
    A8359513(+) tttttC/Tctttt 1 -- ng51 trp30--------
    rs283645841,2
    F8360318(+) AGGGGT/CAGTGG 1 -- ng512Minor allele frequency- C:0.20MN EA 1252
    rs129851691,2
    H8375069(+) tctgtC/Gtcgtc 1 -- ut31 ese34Minor allele frequency- G:0.00EU EA WA 408
    rs129860161,2
    H8375027(+) cctgcA/Tcgcaa 1 -- ut31 ese34Minor allele frequency- T:0.00EU EA WA 414
    About this table

    HapMap Linkage Disequilibrium images for RAB11B (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 604198

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/13 PubMed articles for RAB11B gene (see all 13 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 9230 HGNC: 9761 AceView: RAB11B Ensembl:ENSG00000185236 euGenes: HUgn9230
    ECgene: RAB11B H-InvDB: RAB11B
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for RAB11B Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for RAB11B:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant Proteins
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     Antibodies (Rab11)
     Search OriGene for RAB11B
     Search Tocris compounds for RAB11B




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for RAB11B

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