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Aliases for RAB11A Gene

Aliases for RAB11A Gene

  • RAB11A, Member RAS Oncogene Family 2 3 5
  • Rab-11 3 4
  • YL8 3 4
  • RAB 11A, Member Oncogene Family 3
  • Ras-Related Protein Rab-11A 3
  • RAB11 4

External Ids for RAB11A Gene

Previous GeneCards Identifiers for RAB11A Gene

  • GC15P061897
  • GC15P059260
  • GC15P063740
  • GC15P063877
  • GC15P063948
  • GC15P066161
  • GC15P042986
  • GC15P066018
  • GC15P065784
  • GC15P066280
  • GC15P066274

Summaries for RAB11A Gene

Entrez Gene Summary for RAB11A Gene

  • The protein encoded by this gene belongs to the Rab family of the small GTPase superfamily. It is associated with both constitutive and regulated secretory pathways, and may be involved in protein transport. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

GeneCards Summary for RAB11A Gene

RAB11A (RAB11A, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB11A include Charcot-Marie-Tooth Disease, Type 4C and Microvillus Inclusion Disease. Among its related pathways are Cargo trafficking to the periciliary membrane and Regulation of CFTR activity (norm and CF). GO annotations related to this gene include GTP binding and microtubule binding. An important paralog of this gene is RAB11B.

UniProtKB/Swiss-Prot for RAB11A Gene

  • The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes. May also play a role in melanosome transport and release from melanocytes.

Gene Wiki entry for RAB11A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB11A Gene

Genomics for RAB11A Gene

Regulatory Elements for RAB11A Gene

Enhancers for RAB11A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around RAB11A on UCSC Golden Path with GeneCards custom track

Genomic Location for RAB11A Gene

Chromosome:
15
Start:
65,726,054 bp from pter
End:
65,891,991 bp from pter
Size:
165,938 bases
Orientation:
Plus strand

Genomic View for RAB11A Gene

Genes around RAB11A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB11A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB11A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB11A Gene

Proteins for RAB11A Gene

  • Protein details for RAB11A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62491-RB11A_HUMAN
    Recommended name:
    Ras-related protein Rab-11A
    Protein Accession:
    P62491
    Secondary Accessions:
    • B2R4B6
    • B4DT13
    • P24410
    • Q5TZN9
    • Q9JLX1

    Protein attributes for RAB11A Gene

    Size:
    216 amino acids
    Molecular mass:
    24394 Da
    Quaternary structure:
    • Interacts with RIP11 and STXBP6. Interacts with SGSM1, SGSM2 and SGSM3 (By similarity). Interacts with EXOC6 in a GTP-dependent manner (By similarity). Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 (via its C-terminus) and RAB11FIP4. Interacts with EVI5; EVI5 and RAB11FIP3 may be mutually exclusive and compete for binding RAB11A. Interacts with VIPAS39. Interacts with MYO5B. Found in a complex with MYO5B and CFTR. Interacts with NPC1L1. Interacts (GDP-bound form) with ZFYVE27. Interacts with BIRC6/bruce. May interact with TBC1D14. Interacts with UNC119; in a cell cycle-dependent manner. GDP-bound and nucleotide-free forms interact with SH3BP5 (PubMed:26506309).

    Three dimensional structures from OCA and Proteopedia for RAB11A Gene

    Alternative splice isoforms for RAB11A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAB11A Gene

Post-translational modifications for RAB11A Gene

  • Ubiquitination at Lys 179 and Lys 207
  • Modification sites at PhosphoSitePlus

Other Protein References for RAB11A Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RAB11A (RAB11A)

No data available for DME Specific Peptides for RAB11A Gene

Domains & Families for RAB11A Gene

Gene Families for RAB11A Gene

Suggested Antigen Peptide Sequences for RAB11A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P62491

UniProtKB/Swiss-Prot:

RB11A_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB11A: view

Function for RAB11A Gene

Molecular function for RAB11A Gene

GENATLAS Biochemistry:
RAS related GTP-binding protein,branch rab,member 11,widely expressed with two transcripts small and large,putatively involved in secretory pathway
UniProtKB/Swiss-Prot Function:
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes. May also play a role in melanosome transport and release from melanocytes.

Gene Ontology (GO) - Molecular Function for RAB11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IDA 15837192
GO:0005515 protein binding IPI 12470645
GO:0005525 GTP binding IEA --
GO:0008017 microtubule binding IDA 24561039
GO:0019905 syntaxin binding NAS 12145319
genes like me logo Genes that share ontologies with RAB11A: view
genes like me logo Genes that share phenotypes with RAB11A: view

Animal Models for RAB11A Gene

MGI Knock Outs for RAB11A:

Animal Model Products

CRISPR Products

miRNA for RAB11A Gene

miRTarBase miRNAs that target RAB11A

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RAB11A Gene

Localization for RAB11A Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB11A Gene

Cell membrane; Lipid-anchor. Recycling endosome membrane; Lipid-anchor. Cleavage furrow. Cytoplasmic vesicle, phagosome. Note=Translocates with RAB11FIP2 from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane (PubMed:11994279). Localizes to the cleavage furrow (PubMed:15601896). Colocalizes with PARD3, PRKCI, EXOC5, OCLN, PODXL and RAB8A in apical membrane initiation sites (AMIS) during the generation of apical surface and lumenogenesis (PubMed:20890297). Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211). {ECO:0000269 PubMed:11994279, ECO:0000269 PubMed:15601896, ECO:0000269 PubMed:20890297, ECO:0000269 PubMed:21255211}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB11A Gene COMPARTMENTS Subcellular localization image for RAB11A gene
Compartment Confidence
cytoskeleton 5
cytosol 5
endosome 5
extracellular 5
golgi apparatus 5
plasma membrane 4
endoplasmic reticulum 2
lysosome 2
mitochondrion 2
vacuole 2
nucleus 1

Gene Ontology (GO) - Cellular Components for RAB11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IDA 24561039
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005771 multivesicular body IDA 15634213
GO:0005794 Golgi apparatus IDA 16791210
genes like me logo Genes that share ontologies with RAB11A: view

Pathways & Interactions for RAB11A Gene

genes like me logo Genes that share pathways with RAB11A: view

Gene Ontology (GO) - Biological Process for RAB11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000910 cytokinesis IMP 15601896
GO:0003091 renal water homeostasis TAS --
GO:0007080 mitotic metaphase plate congression IMP 24561039
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0010634 positive regulation of epithelial cell migration IMP 22613965
genes like me logo Genes that share ontologies with RAB11A: view

No data available for SIGNOR curated interactions for RAB11A Gene

Drugs & Compounds for RAB11A Gene

(3) Drugs for RAB11A Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
5'-Guanosine-Diphosphate-Monothiophosphate Experimental Pharma Target 0
Guanosine diphosphate Experimental Pharma Target 0

(2) Additional Compounds for RAB11A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RAB11A: view

Transcripts for RAB11A Gene

mRNA/cDNA for RAB11A Gene

(2) REFSEQ mRNAs :
(14) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RAB11A Gene

RAB11A, member RAS oncogene family:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB11A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: -
SP2:
SP3: - -

Relevant External Links for RAB11A Gene

GeneLoc Exon Structure for
RAB11A
ECgene alternative splicing isoforms for
RAB11A

Expression for RAB11A Gene

mRNA expression in normal human tissues for RAB11A Gene

Protein differential expression in normal tissues from HIPED for RAB11A Gene

This gene is overexpressed in Adipocyte (22.6), Monocytes (10.2), Bone (7.4), and Tlymphocyte (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RAB11A Gene



NURSA nuclear receptor signaling pathways regulating expression of RAB11A Gene:

RAB11A

SOURCE GeneReport for Unigene cluster for RAB11A Gene:

Hs.321541
genes like me logo Genes that share expression patterns with RAB11A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for RAB11A Gene

Orthologs for RAB11A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RAB11A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RAB11A 34
  • 95.83 (n)
  • 99.54 (a)
RAB11A 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAB11A 34
  • 96.3 (n)
  • 100 (a)
RAB11A 35
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rab11a 34
  • 95.83 (n)
  • 100 (a)
Rab11a 16
Rab11a 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RAB11A 34
  • 99.69 (n)
  • 100 (a)
RAB11A 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rab11a 34
  • 94.91 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia RAB11A 35
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAB11A 35
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAB11A 34
  • 86.42 (n)
  • 99.07 (a)
RAB11A 35
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAB11A 35
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rab11a 34
  • 80.25 (n)
  • 98.15 (a)
Str.6874 34
zebrafish
(Danio rerio)
Actinopterygii rab11a 34
  • 78.29 (n)
  • 95.81 (a)
rab11a 35
  • 96 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Rab11 36
  • 85 (a)
Rab11 34
  • 66.98 (n)
  • 85.51 (a)
Rab11 35
  • 86 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004559 34
  • 69.18 (n)
  • 86.79 (a)
worm
(Caenorhabditis elegans)
Secernentea C33D12.6 36
  • 37 (a)
F11A5.3 36
  • 51 (a)
rab-11.1 36
  • 80 (a)
rab-11.1 34
  • 66.83 (n)
  • 82.3 (a)
rab-11.1 35
  • 81 (a)
ManyToMany
rab-11.2 35
  • 70 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER434C 34
  • 55.83 (n)
  • 64.08 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B00671g 34
  • 60.78 (n)
  • 64.22 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPT31 34
  • 60.09 (n)
  • 63.38 (a)
YPT31 35
  • 59 (a)
ManyToMany
YPT32 35
  • 59 (a)
ManyToMany
YPT31 37
thale cress
(Arabidopsis thaliana)
eudicotyledons RABA1f 34
  • 60.66 (n)
  • 69.67 (a)
soybean
(Glycine max)
eudicotyledons Gma.15815 34
rice
(Oryza sativa)
Liliopsida Os05g0564400 34
  • 60.51 (n)
  • 67.3 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3887 34
bread mold
(Neurospora crassa)
Ascomycetes NCU01523 34
  • 64.27 (n)
  • 76.56 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ypt3 34
  • 65.71 (n)
  • 71.15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 44 (a)
ManyToMany
Species where no ortholog for RAB11A was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB11A Gene

ENSEMBL:
Gene Tree for RAB11A (if available)
TreeFam:
Gene Tree for RAB11A (if available)

Paralogs for RAB11A Gene

Pseudogenes.org Pseudogenes for RAB11A Gene

genes like me logo Genes that share paralogs with RAB11A: view

Variants for RAB11A Gene

Sequence variations from dbSNP and Humsavar for RAB11A Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs2660621 -- 65,881,603(-) TGGAA(A/G)ACTTG intron-variant
rs2660622 -- 65,878,944(-) TGTTA(C/T)ATCTA intron-variant
rs2727078 -- 65,871,952(+) ttgga(A/G)acagg intron-variant
rs4514623 -- 65,878,288(+) CTGCT(C/T)AGGAG intron-variant
rs4530073 -- 65,878,188(+) TTTCT(A/G)TTATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAB11A Gene

Variant ID Type Subtype PubMed ID
esv2760035 CNV loss 17122850
nsv471684 CNV gain 15918152
nsv833044 CNV loss 17160897

Variation tolerance for RAB11A Gene

Residual Variation Intolerance Score: 38.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.05; 1.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAB11A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAB11A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB11A Gene

Disorders for RAB11A Gene

MalaCards: The human disease database

(3) MalaCards diseases for RAB11A Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
charcot-marie-tooth disease, type 4c
  • charcot-marie-tooth neuropathy type 4c
microvillus inclusion disease
  • diarrhea 2, with microvillus atrophy
barrett esophagus/esophageal adenocarcinoma
  • esophageal cancer
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for RAB11A

Genetic Association Database (GAD)
RAB11A
Human Genome Epidemiology (HuGE) Navigator
RAB11A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAB11A
genes like me logo Genes that share disorders with RAB11A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RAB11A Gene

Publications for RAB11A Gene

  1. Requirement of myosin Vb.Rab11a.Rab11-FIP2 complex in cholesterol- regulated translocation of NPC1L1 to the cell surface. (PMID: 19542231) Chu B.-B. … Song B.-L. (J. Biol. Chem. 2009) 3 4 22 65
  2. Myosin Vb is required for trafficking of the cystic fibrosis transmembrane conductance regulator in Rab11a-specific apical recycling endosomes in polarized human airway epithelial cells. (PMID: 17462998) Swiatecka-Urban A. … Stanton B.A. (J. Biol. Chem. 2007) 3 4 22 65
  3. Structural basis for Rab11-dependent membrane recruitment of a family of Rab11-interacting protein 3 (FIP3)/Arfophilin-1. (PMID: 17030804) Shiba T. … Wakatsuki S. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3 4 22 65
  4. Crystallographic evidence for substrate-assisted GTP hydrolysis by a small GTP binding protein. (PMID: 15837192) Pasqualato S. … Cherfils J. (Structure 2005) 3 4 22 65
  5. Molecular characterization of Rab11 interactions with members of the family of Rab11-interacting proteins. (PMID: 15173169) Junutula J.R. … Prekeris R. (J. Biol. Chem. 2004) 3 4 22 65

Products for RAB11A Gene

Sources for RAB11A Gene

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