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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RAB11A Gene

protein-coding   GIFtS: 69
GCID: GC15P066018

RAB11A, Member RAS Oncogene Family

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
RAB11A, Member RAS Oncogene Family1 2     Ras-Related Protein Rab-11A2
YL82 3     RAB113
RAB 11A, Member Oncogene Family2     Rab-113
rab-112     

External Ids:    HGNC: 97601   Entrez Gene: 87662   Ensembl: ENSG000001037697   OMIM: 6055705   UniProtKB: P624913   

Export aliases for RAB11A gene to outside databases

Previous GC identifers: GC15P061897 GC15P059260 GC15P063740 GC15P063877 GC15P063948 GC15P066161 GC15P042986


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RAB11A Gene:
The protein encoded by this gene belongs to the Rab family of the small GTPase superfamily. It is associated with
both constitutive and regulated secretory pathways, and may be involved in protein transport. Two transcript
variants encoding different isoforms have been found for this gene. (provided by RefSeq, May 2011)

GeneCards Summary for RAB11A Gene: 
RAB11A (RAB11A, member RAS oncogene family) is a protein-coding gene. Diseases associated with RAB11A include esophagus squamous cell carcinoma, and charcot-marie-tooth disease type 4, and among its related super-pathways are Clathrin-dependent protein traffic and Aquaporin-mediated transport. GO annotations related to this gene include GTP binding and syntaxin binding. An important paralog of this gene is RAB19.

UniProtKB/Swiss-Prot: RB11A_HUMAN, P62491
Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of
transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active
GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible
for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major
regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell
polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes
transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis.
Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in
nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma
membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma
membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes.
May also play a role in melanosome transport and release from melanocytes

Gene Wiki entry for RAB11A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010194.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RAB11A gene promoter:
         SRF   Sox5   SRF (504 AA)   Lmo2   C/EBPalpha   Roaz   GATA-1   S8   NRF-2   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RAB11A promoter sequence
   Search SABiosciences Chromatin IP Primers for RAB11A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB11A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q22.31   Ensembl cytogenetic band:  15q22.31   HGNC cytogenetic band: 15q22.31

RAB11A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAB11A gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P066018:  view genomic region     (about GC identifiers)

Start:
66,018,392 bp from pter      End:
66,184,329 bp from pter
Size:
165,938 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RB11A_HUMAN, P62491 (See protein sequence)
Recommended Name: Ras-related protein Rab-11A precursor  
Size: 216 amino acids; 24394 Da
Subunit: Interacts with RIP11 and STXBP6. Interacts with SGSM1, SGSM2 and SGSM3 (By similarity). Interacts with
EXOC6 in a GTP-dependent manner (By similarity). Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 (via its
C-terminus) and RAB11FIP4. Interacts with EVI5; EVI5 and RAB11FIP3 may be mutually exclusive and compete for
binding RAB11A. Interacts with VIPAS39. Interacts with MYO5B. Found in a complex with MYO5B and CFTR. Interacts
with NPC1L1. Interacts (GDP-bound form) with ZFYVE27. Interacts with BIRC6/bruce. May interact with TBC1D14
Subcellular location: Cell membrane; Peripheral membrane protein. Recycling endosome membrane; Peripheral membrane
protein. Cleavage furrow. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor;
Cytoplasmic side (By similarity). Note=Translocates with RAB11FIP2 from the vesicles of the endocytic recycling
compartment (ERC) to the plasma membrane. Localizes to the cleavage furrow. Colocalizes with PARD3, PRKCI, EXOC5,
OCLN, PODXL and RAB8A in apical membrane initiation sites (AMIS) during the generation of apical surface and
lumenogenesis. Recruited to phagosomes containing S.aureus or M.tuberculosis
6/8 PDB 3D structures from and Proteopedia for RAB11A (see all 8):
1OIV (3D)        1OIW (3D)        1OIX (3D)        1YZK (3D)        2D7C (3D)        2GZD (3D)    
Secondary accessions: B2R4B6 B4DT13 P24410 Q5TZN9 Q9JLX1
Alternative splicing: 2 isoforms:  P62491-1   P62491-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RAB11A: NX_P62491

Explore proteomics data for RAB11A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P62491

  • RAB11A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RAB11A Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001193765.1  NP_004654.1  

    ENSEMBL proteins: 
     ENSP00000455567   ENSP00000261890   ENSP00000454381   ENSP00000456638   ENSP00000456420  
     ENSP00000454673   ENSP00000405767  
    Reactome Protein details: P62491
    Human Recombinant Protein Products for RAB11A: 
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    ProSpec Recombinant Protein for RAB11A
    Cloud-Clone Corp. Proteins for RAB11A 

    Gene Ontology (GO): 5/16 cellular component terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion IEA--
    GO:0005802trans-Golgi network IDA15229288
    GO:0005886plasma membrane IEA--

    RAB11A for ontologies           About GeneDecksing



    RAB11A Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RAB: RAB, member RAS oncogene

    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR003579 Small_GTPase_Rab_type
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry P62491

    ProtoNet protein and cluster: P62491

    3 Blocks protein domains:
    IPB002041 GTP-binding nuclear protein Ran
    IPB003577 Ras small GTPase
    IPB003578 Ras small GTPase


    UniProtKB/Swiss-Prot: RB11A_HUMAN, P62491
    Similarity: Belongs to the small GTPase superfamily. Rab family


    RAB11A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RB11A_HUMAN, P62491
    Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of
    transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active
    GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible
    for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major
    regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell
    polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes
    transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis.
    Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in
    nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma
    membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma
    membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes.
    May also play a role in melanosome transport and release from melanocytes

         Genatlas biochemistry entry for RAB11A:
    RAS related GTP-binding protein,branch rab,member 11,widely expressed with two transcripts small and
    large,putatively involved in secretory pathway

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IDA15837192
    GO:0005515protein binding IPI12470645
    GO:0005525GTP binding IEA--
    GO:0019905syntaxin binding NAS12145319
         
    RAB11A for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RAB11A:
     Decreased focal adhesion (FA)   Increased cell number in S 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RAB11A 
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RAB11A About   (see all 15)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Clathrin-dependent protein traffic
    Clathrin-dependent protein traffic0.66
    wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)0.37
    Transport Clathrin-coated vesicle cycle0.66
    2Regulation of Water Balance by Renal Aquaporins
    Regulation of Water Balance by Renal Aquaporins0.84
    Aquaporin-mediated transport0.84
    3SLC-mediated transmembrane transport
    Transmembrane transport of small molecules0.50
    4wtCFTR and deltaF508 traffic / Membrane expression (norm and CF)
    wtCFTR and deltaF508 traffic / Membrane expression (norm and CF)0.38
    5Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions0.36

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for RAB11A
        Clathrin-dependent protein traffic

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RAB11A
        Remodeling of Adherens Junctions
    Epithelial Tight Junctions

    1 Cell Signaling Technology (CST) Pathway for RAB11A
        Cytoskeletal Signaling

    4 GeneGo (Thomson Reuters) Pathways for RAB11A
        wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
    Cholesterol and Sphingolipids transport / Recycling to plasma membrane in lung (normal and CF)
    wtCFTR and deltaF508 traffic / Membrane expression (norm and CF)
    Transport Clathrin-coated vesicle cycle

    3 BioSystems Pathways for RAB11A
        Arf6 downstream pathway
    Thromboxane A2 receptor signaling
    Notch signaling pathway


    3        Reactome Pathways for RAB11A
        Transmembrane transport of small molecules
    Aquaporin-mediated transport
    Regulation of Water Balance by Renal Aquaporins


    4         Kegg Pathways  (Kegg details for RAB11A):
        Endocytosis
    Endocrine and other factor-regulated calcium reabsorption
    Vasopressin-regulated water reabsorption
    Pancreatic secretion


    RAB11A for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAB11A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/45 Interacting proteins for RAB11A (P624911, 2, 3 ENSP000002618904) via UniProtKB, MINT, STRING, and/or I2D (see all 45)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAB11FIP3O751542, 3, ENSP000002623054MINT-6799685 I2D: score=3 STRING: ENSP00000262305
    RAB3IL1Q8TBN02, 3MINT-66622 I2D: score=5 
    RAB11FIP2Q7L8041, 3, ENSP000003478394EBI-745098,EBI-1049676 I2D: score=3 STRING: ENSP00000347839
    RAB11FIP5Q9BXF63, ENSP000002580984I2D: score=4 STRING: ENSP00000258098
    GDI2P503953, ENSP000003695384I2D: score=3 STRING: ENSP00000369538
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000910cytokinesis IMP15601896
    GO:0006184GTP catabolic process ----
    GO:0006833water transport TAS--
    GO:0006886intracellular protein transport ----
    GO:0006913nucleocytoplasmic transport ----

    RAB11A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RAB11A for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for RAB11A (RB11A)

    2 DrugBank Compounds for RAB11A    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    5'-Guanosine-Diphosphate-Monothiophosphate-- --target--17139284 17016423 10592235
    Guanosine-5'-Diphosphate-- 146-91-8target--17139284 17016423 10592235

    3 Novoseek inferred chemical compound relationships for RAB11A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 52.3 16 9600939 (3), 14699104 (2), 10077598 (2), 8922376 (1) (see all 9)
    gdp 40.2 4 14699104 (2), 8188702 (1), 15837192 (1)
    glucose 0 1 17158030 (1)

    Search CenterWatch for drugs/clinical trials and news about RAB11A / RB11A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RAB11A gene (2 alternative transcripts): 
    NM_001206836.1  NM_004663.4  

    Unigene Cluster for RAB11A:

    RAB11A, member RAS oncogene family
    Hs.321541  [show with all ESTs]
    Unigene Representative Sequence: NM_004663
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000569304 ENST00000563580 ENST00000568850 ENST00000564910 ENST00000261890(uc002apk.3 uc010ujk.2)
    ENST00000566233 ENST00000565075 ENST00000569896 ENST00000567671 ENST00000435304

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AF000231.1 AF498946.1 AK297549.1 AK298961.1 AK300008.1 AK311770.1 BC013348.2 BC047114.1 
    BT020151.1 BT020154.1 CR407669.1 CR536493.1 X53143.1 X56740.1 

    19 DOTS entries:

    DT.100827594  DT.449969  DT.97795542  DT.100827606  DT.100827603  DT.92457074  DT.453180  DT.97859949 
    DT.121029061  DT.95257491  DT.121028925  DT.121028951  DT.121028994  DT.121029068  DT.100827601  DT.101964760 
    DT.121028932  DT.121028969  DT.95204929 

    2 AceView cDNA sequences:

    AK054930 AL138360 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for RAB11A    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
    SP1:        -                                       
    SP2:                                                
    SP3:        -                 -                     


    ECgene alternative splicing isoforms for RAB11A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RAB11A expression in normal human tissues (normalized intensities)      RAB11A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTATGGCTTC
    RAB11A Expression
    About this image


    RAB11A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/31 selected tissues (see all 31) fully expand
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
             platelets   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             colon ; peripheral nerve/ganglion   
     
     Breast
             breast ; myoepithelial cells   

    See RAB11A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RAB11A

    SOURCE GeneReport for Unigene cluster: Hs.321541
        SABiosciences Custom PCR Arrays for RAB11A
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RAB11A gene from 10/25 species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rab11a1 , 5 RAB11a, member RAS oncogene family1, 5 95.83(n)1
    100(a)1
      9 (34.87 cM)5
    538691  NM_017382.51  NP_059078.21 
     647152995 
    chicken
    (Gallus gallus)
    Aves RAB11A1 RAB11A, member RAS oncogene family 86.42(n)
    99.07(a)
      415544  NM_001005827.1  NP_001005827.1 
    lizard
    (Anolis carolinensis)
    Reptilia RAB11A6
    RAB11A, member RAS oncogene family
    98(a)
    1 ↔ 1
    GL343503.1(391792-409474)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA971292.12   -- 80.77(n)    CA971292.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rab11a1 RAB11a, member RAS oncogene family 78.29(n)
    95.81(a)
      492487  NM_001007359.1  NP_001007360.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rab111 , 3 endocytosis GTP binding3
    Rab-protein 111
    85(a)3
    66.98(n)1
    85.51(a)1
      93B133
    425011  NM_134310.21  NP_599137.11 
    worm
    (Caenorhabditis elegans)
    Secernentea rab-11.11 , 3 RAS-related protein3
    Protein RAB-11.11
    80(a)
    (best of 3)3
    66.19(n)1
    81.82(a)1
      I(109162-110487)3
    1716011  NM_058274.21  NP_490675.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YPT31(YER031C)4
    YPT311
    Rab family GTPase, very similar to Ypt32p; involved more4
    Ypt31p1
    60.53(n)1
    64.68(a)1
      5(214747-214076)4
    8567531, 4  NP_010948.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons RAB11c1 Ras-related protein RABA2a 63.82(n)
    71.56(a)
      837490  NM_100835.2  NP_172434.1 
    rice
    (Oryza sativa)
    Liliopsida Os05g01051001 hypothetical protein 61.93(n)
    70.62(a)
      4337555  NM_001060943.1  NP_001054408.1 


    ENSEMBL Gene Tree for RAB11A (if available)
    TreeFam Gene Tree for RAB11A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RAB11A gene
    RAB192  RAB39A2  RAB2A2  RAB252  RAB432  RAB142  RAB4B2  RAB39B2  
    RAB11B2  RAB422  RAB4A2  RAB302  RAB4B-EGLN22  RAB2B2  
    18/102 SIMAP similar genes for RAB11A using alignment to 6 protein entries:     RB11A_HUMAN (see all proteins) (see all similar genes):
    RAB11B    RAB25    RAB19    RAB43    DKFZp686J06205    RAB13
    RAB30    rab1b    RAB8B    RAB3A    RAB5C    DKFZp686J07132
    RAB5B    RAB7A    RAB38    RAB15    RAB8A    RAB2B

    RAB11A for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for RAB11A
    PGOHUM00000258503 PGOHUM00000239504


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/512 SNPs in RAB11A are shown (see all 512)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1381755091,2
    C--66159910(+) AAGCAC/TGGAAA 2 -- us2k10--------
    rs744242691,2
    C,F--66160002(+) TAAAGT/CTCTGT 2 -- us2k14Minor allele frequency- C:0.08NA WA 242
    rs1427775981,2
    --66160009(+) CTGTAC/GGTCAC 2 -- us2k10--------
    rs1460828691,2
    --66160034(+) TCTCAC/TTGGGC 2 -- us2k10--------
    rs798230021,2
    C--66160060(+) AGCAGC/GGCTGT 2 -- us2k10--------
    rs600178461,2
    F--66160199(+) TTCAAG/TTCACA 2 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1495082591,2
    C--66160298(+) GTGGCA/GTGGTA 2 -- us2k10--------
    rs1440895391,2
    C--66160322(+) ACCTCC/TGCTTC 2 -- us2k10--------
    rs1486659331,2
    --66160328(+) GCTTCC/TCGGGT 2 -- us2k10--------
    rs1421980261,2
    C--66160422(+) AGTAGC/TGACAG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for RAB11A (66018392 - 66184329 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for RAB11A:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv904323CNV Loss21882294
    nsv833044CNV Loss17160897
    nsv471684CNV Gain15918152
    dgv751e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605570    OMIM disorders: --

    16 diseases for RAB11A:    About MalaCards
    esophagus squamous cell carcinoma    charcot-marie-tooth disease type 4    barrett's esophagus    tooth disease
    charcot-marie-tooth disease    cholestasis    cystic fibrosis    influenza
    squamous cell carcinoma    schizophrenia    neuroblastoma    tuberculosis
    pancreatitis    endotheliitis    breast cancer    neuronitis

    1 disease from the University of Copenhagen DISEASES database for RAB11A:
    Esophagus squamous cell carcinoma

    RAB11A for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for RAB11A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    barrett esophagus 24 1 9389793 (1)
    dysplasia 0 7 9389793 (4), 10212817 (2)
    adenocarcinoma 0 1 9389793 (1)

    Genetic Association Database (GAD): RAB11A
    Human Genome Epidemiology (HuGE) Navigator: RAB11A (1 document)

    Export disorders for RAB11A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RAB11A gene, integrated from 9 sources (see all 190):
    (articles sorted by number of sources associating them with RAB11A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human rab11a: transcription, chromosome mapping and effect on the expression levels of host GTP-binding proteins. (PubMed id 9662449)1, 2, 3 Gromov P.S....Madsen P. (1998)
    2. Identification and characterization of a human homolog of the Schizosaccharomyces pombe ras-like gene YPT-3. (PubMed id 1704119)1, 2, 3 Drivas G.T.... Rush M.G. (1991)
    3. Molecular characterization of Rab11 interactions with members of the family of Rab11-interacting proteins. (PubMed id 15173169)1, 2, 9 Junutula J.R....Prekeris R. (2004)
    4. Structural basis for Rab11-dependent membrane recruitment of a family of Rab11-interacting protein 3 (FIP3)/Arfophilin-1. (PubMed id 17030804)1, 2, 9 Shiba T....Wakatsuki S. (2006)
    5. Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein. (PubMed id 11786538)1, 2, 9 Lindsay A.J.... McCaffrey M.W. (2002)
    6. Requirement of myosin Vb.Rab11a.Rab11-FIP2 complex in cholesterol-regulated translocation of NPC1L1 to the cell surface. (PubMed id 19542231)1, 2, 9 Chu B.B....Song B.L. (2009)
    7. Myosin Vb is required for trafficking of the cystic f ibrosis transmembrane conductance regulator in Rab11a-specific apical recycling endosomes in polarized human airway epithelial cells. (PubMed id 17462998)1, 2, 9 Swiatecka-Urban A....Stanton B.A. (2007)
    8. The RCP-Rab11 complex regulates endocytic protein sorting. (PubMed id 15181150)1, 2, 9 Peden A.A....Prekeris R. (2004)
    9. Crystallographic evidence for substrate-assisted GTP hydrolysis by a small GTP binding protein. (PubMed id 15837192)1, 2, 9 Pasqualato S. and Cherfils J. (2005)
    10. TBC1D14 regulates autophagosome formation via Rab11- a nd ULK1-positive recycling endosomes. (PubMed id 22613832)1, 2 Longatti A....Tooze S.A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8766 HGNC: 9760 AceView: RAB11A.1 Ensembl:ENSG00000103769 euGenes: HUgn8766
    ECgene: RAB11A Kegg: 8766 H-InvDB: RAB11A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RAB11A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAB11A Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RAB11A gene:
    Search GeneIP for patents involving RAB11A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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