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RAB11A Gene

protein-coding   GIFtS: 66

GC15P063948
RAB11A, member RAS oncogene family
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
MGC1490 2
RAB11 3
Rab-11 3
YL8 1, 2, 3
Descriptions
RAB 11A, member oncogene family 2
RAB11A, member RAS oncogene family 2
Ras-related protein Rab-11A 2
External Ids
HGNC: 97601
Entrez Gene: 87662
UniProtKB: P624913
Ensembl: ENSG000001037697
Search outside databases for aliases for RAB11A gene

Previous GC identifers: GC15P061897 GC15P059260 GC15P063740 GC15P063877

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for RAB11A:
The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. It is
associated with both constitutive and regulated secretory pathways, and may be involved in protein
transport. [provided by RefSeq]

UniProtKB/Swiss-Prot: RB11A_HUMAN, P62491
Function: Modulates endosomal trafficking (By similarity)

Gene Wiki entry for RAB11A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the RAB11A gene  

Entrez Gene cytogenetic band: 15q21.3-q22.31   Ensembl cytogenetic band:  15q22.31   HGNC cytogenetic band: 15q22.31

RAB11A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P063948:     (about GC identifiers)

Start:
63,948,850 bp from pter
End:
63,968,846 bp from pter
Size:
19,997 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000015.8  NT_010194.16  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: RB11A_HUMAN, P62491 (See protein sequence)
Recommended Name: Ras-related protein Rab-11A  
Size: 216 amino acids; 24394 Da
Subunit: Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 and RAB11FIP4. Binds RIP11 and STXBP6.
Interacts with SGSM1, SGSM2 and SGSM3 (By similarity)
Subcellular location: Cell membrane; Peripheral membrane protein. Recycling endosome membrane;
Peripheral membrane protein. Note=Translocates with RAB11FIP2 from the vesicles of the endocytic
recycling compartment (ERC) to the plasma membrane
PDB structures from and Proteopedia :
1OIV (3D)    1OIW (3D)    1OIX (3D)    1YZK (3D)    2D7C (3D)    2GZD (3D)    2GZH (3D)    2HV8 (3D)    
Secondary accessions: P24410 Q5TZN9 Q9JLX1

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_004654.1  

    ENSEMBL proteins: 
    ENSP00000261890 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Sigma-Aldrich AQUA Peptides for RAB11A  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (Rab11A)
    Human Recombinant Proteins from Abnova (RAB11A)
                  OriGene Purified Recombinant Human Protein: RAB11A 

    4 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005768 endosome IEA--
    GO:0005802 trans-Golgi network IDA15229288
    GO:0005886 plasma membrane IEA--
    GO:0055038 recycling endosome membrane IEA--
    About this table

    Antibodies for RAB11A: 
    Invitrogen Antibodies for RAB11A
    Millipore Mono- and Polyclonal Antibodies for the study of RAB11A
    Sigma-Aldrich Antibodies for RAB11A
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for RAB11A 
    Antibodies from Abcam (Rab11A), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (RAB11A)
    Novus Biologicals Antibodies for RAB11A

    Assays for RAB11A: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5 InterPro domains/families:
     IPR015595 Rab11
     IPR001806 Ras_GTPase
     IPR005225 Small_GTP_bd
     IPR003579 GTPase_Rab
     IPR013753 Ras


       GeneDecks  RAB11A for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P62491

    ProtoNet protein and cluster: P62491

    3 Blocks protein families:
    IPB002041 GTP-binding nuclear protein Ran
    IPB003577 Ras small GTPase
    IPB003578 Ras small GTPase


    UniProtKB/Swiss-Prot: RB11A_HUMAN, P62491
    Similarity: Belongs to the small GTPase superfamily. Rab family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (RAB11A)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (RAB11A)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004663

                  Applied Biosystems Silencer® siRNAs for RAB11A

                  Sigma-Aldrich siRNA for RAB11A  
                         Sigma-Aldrich shRNA for RAB11A  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_004663
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_004663
                                     untagged cDNA clone in CMV expression vector: NM_004663 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_004663

    UniProtKB/Swiss-Prot: RB11A_HUMAN, P62491
    Function: Modulates endosomal trafficking (By similarity)

    Genatlas biochemistry entry for RAB11A:
    RAS related GTP-binding protein,branch rab,member 11,widely expressed with two transcripts small
    and large,putatively involved in secretory pathway

    5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0003924 GTPase activity NAS11163216
    GO:0005215 transporter activity NAS11163216
    GO:0005515 protein binding NAS11163216
    GO:0005525 GTP binding IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    1 Millipore Pathway for RAB11A
     Clathrin-dependent protein traffic

       GeneDecks  RAB11A for the pathways selected above  
    About GeneDecksing

    2 Sigma-Aldrich "Your Favorite Gene" Pathways for  RAB11A  (Your Favorite Gene powered by Ingenuity) 
     Fc&gamma
     Clathrin-mediated Endocytosis

       GeneDecks  RAB11A for the pathways selected above  
    About GeneDecksing

     Gene Network CentralTM Interacting Genes and Proteins Network for  RAB11A 


    5/30 Interacting proteins for RAB11A (ENSP000002618903 P624911, 2) via UniProtKB, MINT, and/or STRING (see all 30 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAB11FIP1Q6WKZ41STRING (score=.999) EBI-745098, EBI-1043591
    HGSO149642MINT-3369790
    RAB11FIP3O751542MINT-6799685
    RAB14P611062MINT-3369790
    RAB3IL1Q8TBN02MINT-66622
    About this table

    3 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007264 small GTPase mediated signal transduction IEA--
    GO:0015031 protein transport IEA--
    GO:0048227 plasma membrane to endosome transport NAS11163216
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for RAB11A
    3 Novoseek chemical compound relationships for RAB11A gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 54.32 16 9600939 (3), 14699104 (2), 10077598 (2), 8922376 (1) (see all 9)
    gdp 42.72 4 14699104 (2), 8188702 (1), 15837192 (1)
    glucose 0.00 1 17158030 (1)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (RAB11A)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (RAB11A)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004663

                  Sigma-Aldrich siRNA for RAB11A  
                         Sigma-Aldrich shRNA for RAB11A  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_004663  

    REFSEQ mRNAs for RAB11A gene: 

    NM_004663.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_004663  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_004663
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_004663
                                     untagged cDNA clone in CMV expression vector: NM_004663 

    Additional cDNA sequence: 

    AF000231.1 AF498946.1 AK297549.1 AK298961.1 AK300008.1 AK311770.1 BC013348.2 BT020151.1 
    BT020154.1 CR407669.1 CR536493.1 CR606451.1 X53143.1 X56740.1 

    19 DOTS entries:

    DT.100827594  DT.449969  DT.97795542  DT.100827606  DT.100827603  DT.92457074  DT.97859949  DT.121029061 
    DT.95257491  DT.121028925  DT.121028951  DT.121028994  DT.121029068  DT.100827601  DT.101964760  DT.121028932 
    DT.121028969  DT.453180  DT.95204929 

    2 AceView cDNA sequences:

    AK054930 AL138360 

    highest scoring ESTs for RAB11A:

    AF000231 AA135502 AA151236 AA320896 AA331591 AA363625 AA371154 AA376084 AA443064 AA454010 

    Unigene Cluster for RAB11A:

    RAB11A, member RAS oncogene family
    Hs.321541  [show with all ESTs]
    Unigene Representative Sequence: BC013348


    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for RAB11A

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
    SP1:        -                                       
    SP2:                                                
    SP3:        -                 -                     

    About this scheme

    ECgene alternative splicing isoforms for RAB11A

    1 Ensembl transcript including schematic representation:
    ENST00000261890  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    RAB11A expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for RAB11A

    1 / 2 / 3

    5 probe-sets matching RAB11A gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    36660_at2, 3 U95-A 1 0.94 1.00 1.00 1.00 AF000231 1.00 1.00 1.00 1

    200864_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_004663 0.60 1.00 0.82 1

    200863_s_at2, 3 U133-A 2 1.00 0.95 -- -- AI215102 0.80 1.00 0.91 1

    200864_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    200863_s_at2 U133Plus2 2 1.00 0.95 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: CTATGGCTTC

    SOURCE GeneReport for Unigene cluster: Hs.321541

    Expression variation in blood from EXPOLDB for RAB11A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for RAB11A gene from 5/21 species (see all 21 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    RAB11A1   -- RAB11A, member RAS oncogene family 96.3(n)
    100(a)
    403957  XM_850496.1  XP_855589.1 
    chimpanzee
    (Pan troglodytes)
    RAB11A1   -- RAB11A, member RAS oncogene family 99.69(n)
    100(a)
    453523  XM_510490.2  XP_510490.2 
    cow
    (Bos taurus)
    RAB11A1   -- RAB11A, member RAS oncogene family 95.83(n)
    99.54(a)
    534708  NM_001038162.1  NP_001033251.1 
    rat
    (Rattus norvegicus)
    Rab11a1   -- RAB11a, member RAS oncogene family 94.91(n)
    100(a)
    81830  NM_031152.2  NP_112414.1 
    mouse
    (Mus musculus)
    Rab11a1, 5 95
    RAB11a, member RAS oncogene family1, 5 95.83(n)1
    100(a)1
    538691  NM_017382.41  NP_059078.21 
     AA1727885  AB2326055  (see all 20)
    About this table        Species with no ortholog for RAB11A

    ENSEMBL Gene Tree for RAB11A
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for RAB11A gene
    RAB352  RAB252  RAB11B2  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/94 NCBI SNPs in RAB11A are shown (see all 94 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 43)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 15 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs125916421,2
    A,C,F,H63968990(+) TTAGAA/CCTGCA 1 -- ng314Minor allele frequency- C:0.50EU EA WA 418
    --
    rs129092651,2
    C,F,H63948777(+) CCCTTG/CTTGGG 1 -- ng519Minor allele frequency- C:0.07NA MN EA EU WA 918
    --
    rs49201,2
    C,F,H63967202(+) AACAAG/TCCAAA 1 K/N mis19Minor allele frequency- T:0.00MN EU EA WA 1012
    rs80281181,2
    H63947924(+) TGATAT/ACTGGC 1 -- ng514Minor allele frequency- A:0.00EU EA WA 418
    --
    rs115564611,2
    H63967194(-) GTTTTC/TAGTGG 1 E/K mis1 ese34Minor allele frequency- T:0.00EU EA WA 404
    --
    rs11308141,2
    C63968114(+) CTTAGA/GACCTT 1 -- ut310--------
    rs45300731,2
    A,C,F,H63957580(+) TTTCTA/GTTATG 1 -- int112Minor allele frequency- N:0.00EU EA WA NA 1048
    rs116347251,2
    C,F,H63954466(+) gTGCTG/CGAAGt 1 -- int14Minor allele frequency- C:0.02EU EA WA 420
    rs118563641,2
    C,F,H63960490(+) TACCTA/TTTTTA 1 -- int14Minor allele frequency- T:0.01EU EA WA 392
    --
    rs116342401,2
    A,F,H63966641(+) tctcaC/Tgacaa 1 -- int14Minor allele frequency- T:0.02EU EA WA 412
    About this table

    HapMap Linkage Disequilibrium images for RAB11A (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 605570

    3 Novoseek disease relationships for RAB11A gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    barrett esophagus 27.10 1 9389793 (1)
    dysplasia 0.00 7 9389793 (4), 10212817 (2)
    adenocarcinoma 0.00 1 9389793 (1)
    About this table

    1 PharmGKB disease relationship for RAB11A gene
    Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
    Leukemia, Lymphocytic, Acute, L1FA  GN  12730115
    About this table

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/117 PubMed articles for RAB11A gene (see all 117 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 8766 HGNC: 9760 AceView: RAB11A.1 Ensembl:ENSG00000103769 euGenes: HUgn8766
    ECgene: RAB11A H-InvDB: RAB11A
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for RAB11A Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for RAB11A:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Lentivirus-delivered shRNAs for RAB11A Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant & Natural Proteins  

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     Antibodies & Assays for RAB11A 

     Recombinant Proteins
    (Rab11A)
     Antibodies (Rab11A)
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     Search Tocris compounds for RAB11A




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for RAB11A

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