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Aliases & Descriptions for RAB11A
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| MGC1490 2 | | RAB11 3 | | Rab-11 3 | | YL8 1, 2, 3 |
| | | Descriptions |
|---|
| RAB 11A, member oncogene family 2 | | RAB11A, member RAS oncogene family 2 | | Ras-related protein Rab-11A 2 |
|
| | Search outside databases for aliases for RAB11A genePrevious GC identifers: GC15P061897 GC15P059260 GC15P063740 GC15P063877 |
Summaries for RAB11A(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for RAB11A: The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. It is associated with both constitutive and regulated secretory pathways, and may be involved in protein transport. [provided by RefSeq] UniProtKB/Swiss-Prot: RB11A_HUMAN, P62491Function: Modulates endosomal trafficking (By similarity)Gene Wiki entry for RAB11A |
Genomic Location for RAB11A
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the RAB11A gene 
Entrez Gene cytogenetic band: 15q21.3-q22.31 Ensembl cytogenetic band: 15q22.31 HGNC cytogenetic band: 15q22.31RAB11A Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15P063948:
(about GC identifiers)
Start:
|
63,948,850 bp from pter |
End:
|
63,968,846 bp from pter |
Size:
|
19,997 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000015.8 NT_010194.16
| Proteins for RAB11A
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: RB11A_HUMAN, P62491 (See
protein sequence)Recommended Name: Ras-related protein Rab-11A Size: 216 amino acids; 24394 Da
Subunit: Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 and RAB11FIP4. Binds RIP11 and STXBP6. Interacts with SGSM1, SGSM2 and SGSM3 (By similarity)
Subcellular location: Cell membrane; Peripheral membrane protein. Recycling endosome membrane; Peripheral membrane protein. Note=Translocates with RAB11FIP2 from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane
PDB structures from and Proteopedia :1OIV (3D)
 1OIW (3D)
 1OIX (3D)
 1YZK (3D)
 2D7C (3D)
 2GZD (3D)
 2GZH (3D)
 2HV8 (3D)
 
Secondary accessions: P24410 Q5TZN9 Q9JLX1Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_004654.1
ENSEMBL proteins: ENSP00000261890
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: RAB11A 
4 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for RAB11A: Assays for RAB11A: | Protein
Domains/ Families for RAB11A(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P62491
ProtoNet protein and cluster: P62491 3 Blocks protein families: IPB002041 GTP-binding nuclear protein Ran IPB003577 Ras small GTPase IPB003578 Ras small GTPase
UniProtKB/Swiss-Prot: RB11A_HUMAN, P62491Similarity: Belongs to the small GTPase superfamily. Rab family | Gene Function for RAB11A
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004663
Applied Biosystems Silencer® siRNAs for RAB11A
Sigma-Aldrich siRNA for RAB11A  Sigma-Aldrich shRNA for RAB11A  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004663                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_004663                                  untagged cDNA clone in CMV expression vector: NM_004663 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_004663
UniProtKB/Swiss-Prot: RB11A_HUMAN, P62491Function: Modulates endosomal trafficking (By similarity)Genatlas biochemistry entry for RAB11A:RAS related GTP-binding protein,branch rab,member 11,widely expressed with two transcripts small and large,putatively involved in secretory pathway5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6
): About this table | Pathways & Interactions for RAB11A
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
2 Sigma-Aldrich "Your Favorite Gene" Pathways for RAB11A (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for RAB11A 
5/30 Interacting proteins for RAB11A (ENSP000002618903 P624911, 2) via UniProtKB, MINT, and/or STRING (see all 30
)About this table
3 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007264 | small GTPase mediated signal transduction |
IEA | -- | | GO:0015031 | protein transport |
IEA | -- | | GO:0048227 | plasma membrane to endosome transport |
NAS | 11163216 | About this table
|
Drugs & Compounds for RAB11A(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for RAB11A 3 Novoseek chemical compound relationships for RAB11A gene
About this table
|
Transcripts for RAB11A(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004663
Sigma-Aldrich siRNA for RAB11A  Sigma-Aldrich shRNA for RAB11A  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_004663 REFSEQ mRNAs for RAB11A gene: NM_004663.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_004663               OriGene GFP tagged cDNA clone in CMV expression vector: NM_004663                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_004663                                  untagged cDNA clone in CMV expression vector: NM_004663  Additional cDNA sequence: AF000231.1 AF498946.1 AK297549.1 AK298961.1 AK300008.1 AK311770.1 BC013348.2 BT020151.1 BT020154.1 CR407669.1 CR536493.1 CR606451.1 X53143.1 X56740.1 19 DOTS entries: DT.100827594 DT.449969 DT.97795542 DT.100827606 DT.100827603 DT.92457074 DT.97859949 DT.121029061 DT.95257491 DT.121028925 DT.121028951 DT.121028994 DT.121029068 DT.100827601 DT.101964760 DT.121028932 DT.121028969 DT.453180 DT.95204929 2 AceView cDNA sequences:AK054930 AL138360
highest scoring ESTs for RAB11A:AF000231 AA135502 AA151236 AA320896 AA331591 AA363625 AA371154 AA376084 AA443064 AA454010 Unigene Cluster for RAB11A: RAB11A, member RAS oncogene family Hs.321541 [show with all ESTs]Unigene Representative Sequence: BC013348
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for RAB11A
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | |
| SP1: | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | - |   | |   | |   | - |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for RAB11A
1 Ensembl transcript including schematic representation: ENST00000261890
|
Expression for RAB11A
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| RAB11A expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for RAB11A
1 / 2 / 3 5 probe-sets matching RAB11A gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: CTATGGCTTC
SOURCE GeneReport for Unigene cluster: Hs.321541
Expression variation in blood from EXPOLDB for RAB11A |
Orthologs for RAB11A
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for RAB11A gene from 5/21 species (see all 21
)
About this table Species with no ortholog for RAB11A
ENSEMBL Gene Tree for RAB11A | Paralogs for RAB11A(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for RAB11A gene
- RAB352 RAB252 RAB11B2
|
SNPs/Variants for RAB11A(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for RAB11A (up to first 250kb)
|
Disorders & Mutations for RAB11A
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 605570
3 Novoseek disease relationships for RAB11A gene
About this table
1 PharmGKB disease relationship for RAB11A geneAbout this table
|
Medical News for RAB11A(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for RAB11A (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/117 PubMed articles for RAB11A gene (see all 117
):- Human rab11a: transcription, chromosome mapping and effect on the expression levels of host GTP-binding proteins. (PubMed id 9662449)2, 3, 4 Gromov P.S....Madsen P. (1998)
- Identification and characterization of a human homolog of the Schizosaccharomyces pombe ras-like gene YPT-3. (PubMed id 1704119)2, 3, 4 Drivas G.T.... Rush M.G. (1991)
- Molecular characterization of Rab11 interactions with members of the family of Rab11-interacting proteins. (PubMed id 15173169)1, 3, 4 Junutula J.R....Prekeris R. (2004)
- Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein. (PubMed id 11786538)1, 3, 4 Lindsay A.J.... McCaffrey M.W. (2002)
- The RCP-Rab11 complex regulates endocytic protein sorting. (PubMed id 15181150)1, 3, 4 Peden A.A....Prekeris R. (2004)
- The C2 domains of the class I Rab11 family of interacting proteins target recycling vesicles to the plasma membrane. (PubMed id 15304524)3, 4 Lindsay A.J. and McCaffrey M.W. (2004)
- Characterisation of the Rab binding properties of Rab coupling protein (RCP) by site-directed mutagenesis. (PubMed id 15280022)3, 4 Lindsay A.J. and McCaffrey M.W. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Rab11-FIP2 functions in transferrin recycling and associates with endosomal membranes via its COOH-terminal domain. (PubMed id 11994279)3, 4 Lindsay A.J. and McCaffrey M.W. (2002)
- Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and its overexpression condenses the Rab11 positive compartment in HeLa cells. (PubMed id 12470645)3, 4 Wallace D.M.... McCaffrey M.W. (2002)
|
Search for RAB11A
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing RAB11A
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing RAB11A
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RAB11A(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for RAB11A(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for RAB11A:

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Incremental update: 13 Oct 2009
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