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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RAB10 Gene

protein-coding   GIFtS: 58
GCID: GC02P026256

RAB10, Member RAS Oncogene Family

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
RAB10, Member RAS Oncogene Family1 2
Ras-Related GTP-Binding Protein1 2
GTP-Binding Protein RAB102
Ras-Related Protein Rab-102

External Ids:    HGNC: 97591   Entrez Gene: 108902   Ensembl: ENSG000000847337   OMIM: 6126725   UniProtKB: P610263   

Export aliases for RAB10 gene to outside databases

Previous GC identifers: GC02P026178 GC02P026349 GC02P026231 GC02P026168 GC02P025993


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RAB10 Gene:
RAB10 belongs to the RAS (see HRAS; MIM 190020) superfamily of small GTPases. RAB proteins localize to exocytic
and endocytic compartments and regulate intracellular vesicle trafficking (Bao et al., 1998 (PubMed
9918381)).(supplied by OMIM, Mar 2009)

GeneCards Summary for RAB10 Gene: 
RAB10 (RAB10, member RAS oncogene family) is a protein-coding gene. Diseases associated with RAB10 include psoriasis, and insulin resistance, and among its related super-pathways are Translocation of GLUT4 to the Plasma Membrane and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include myosin V binding and GTP binding. An important paralog of this gene is RAB3B.

UniProtKB/Swiss-Prot: RAB10_HUMAN, P61026
Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of
transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active
GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible
for vesicle formation, movement, tethering and fusion (By similarity). That Rab is mainly involved in the
biosynthetic transport of proteins from the Golgi to the plasma membrane. Regulates, for instance, SLC2A4/GLUT4
glucose transporter-enriched vesicles delivery to the plasma membrane. In parallel, it regulates the transport of
TLR4, a toll-like receptor to the plasma membrane and therefore may be important for innate immune response.
Plays also a specific role in asymmetric protein transport to the plasma membrane within the polarized neuron and
epithelial cells. In neurons, it is involved in axonogenesis through regulation of vesicular membrane trafficking
toward the axonal plasma membrane while in epithelial cells, it regulates transport from the Golgi to the
basolateral membrane. Moreover, may play a role in the basolateral recycling pathway and in phagosome maturation.
According to PubMed:23263280, may play a role in endoplasmic reticulum dynamics and morphology controlling
tubulation along microtubules and tubules fusion

Gene Wiki entry for RAB10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RAB10 gene promoter:
         Pax-5   p300   Olf-1   IRF-1   HNF-3beta   AP-2gamma   E47   Egr-2   FOXO4   Hand1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RAB10 promoter sequence
   Search SABiosciences Chromatin IP Primers for RAB10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAB10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23.3   Ensembl cytogenetic band:  2p23.3   HGNC cytogenetic band: 2p23.3

RAB10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAB10 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P026256:  view genomic region     (about GC identifiers)

Start:
26,256,729 bp from pter      End:
26,360,323 bp from pter
Size:
103,595 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RAB10_HUMAN, P61026 (See protein sequence)
Recommended Name: Ras-related protein Rab-10  
Size: 200 amino acids; 22541 Da
Subunit: Interacts with MYO5A; mediates the transport to the plasma membrane of SLC2A4/GLUT4 storage vesicles.
Interacts with GDI1 and maybe with GDI2; negatively regulates RAB10 association with membranes and activation.
Interacts (GDP-bound form) with LLGL1; the interaction is direct and promotes RAB10 association with membranes
and activation through competition with the Rab inhibitor GDI1 (By similarity). Interacts with EXOC4; probably
associates with the exocyst (By similarity)
Subcellular location: Cytoplasmic vesicle membrane; Lipid-anchor (Probable); Cytoplasmic side (Probable). Golgi
apparatus, trans-Golgi network membrane (By similarity). Endosome membrane. Recycling endosome membrane.
Cytoplasmic vesicle, phagosome membrane (By similarity). Cell projection, cilium. Endoplasmic reticulum membrane.
Note=Associates with SLC2A4/GLUT4 storage vesicles. Localizes to the base of the cilium. Transiently associates
with phagosomes (By similarity). According to PubMed:23263280 localizes to the endoplasmic reticulum at domains
of new tubule growth
Secondary accessions: D6W538 O88386 Q6IA52 Q9D7X6 Q9H0T3

Explore the universe of human proteins at neXtProt for RAB10: NX_P61026

Explore proteomics data for RAB10 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P61026

  • RAB10 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RAB10 Protein Expression
    REFSEQ proteins: NP_057215.3  
    ENSEMBL proteins: 
     ENSP00000264710  
    Reactome Protein details: P61026
    Human Recombinant Protein Products for RAB10: 
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    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for RAB10
    Cloud-Clone Corp. Proteins for RAB10 

    Gene Ontology (GO): 5/17 cellular component terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000145colocalizes with exocyst ISS--
    GO:0005622intracellular ----
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0005768endosome IDA--

    RAB10 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RAB: RAB, member RAS oncogene

    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR003579 Small_GTPase_Rab_type
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry P61026

    ProtoNet protein and cluster: P61026

    4 Blocks protein domains:
    IPB002041 GTP-binding nuclear protein Ran
    IPB003577 Ras small GTPase
    IPB003578 Ras small GTPase
    IPB006688 ADP-ribosylation factor


    UniProtKB/Swiss-Prot: RAB10_HUMAN, P61026
    Similarity: Belongs to the small GTPase superfamily. Rab family


    RAB10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RAB10_HUMAN, P61026
    Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of
    transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active
    GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible
    for vesicle formation, movement, tethering and fusion (By similarity). That Rab is mainly involved in the
    biosynthetic transport of proteins from the Golgi to the plasma membrane. Regulates, for instance, SLC2A4/GLUT4
    glucose transporter-enriched vesicles delivery to the plasma membrane. In parallel, it regulates the transport of
    TLR4, a toll-like receptor to the plasma membrane and therefore may be important for innate immune response.
    Plays also a specific role in asymmetric protein transport to the plasma membrane within the polarized neuron and
    epithelial cells. In neurons, it is involved in axonogenesis through regulation of vesicular membrane trafficking
    toward the axonal plasma membrane while in epithelial cells, it regulates transport from the Golgi to the
    basolateral membrane. Moreover, may play a role in the basolateral recycling pathway and in phagosome maturation.
    According to PubMed:23263280, may play a role in endoplasmic reticulum dynamics and morphology controlling
    tubulation along microtubules and tubules fusion
    Enzyme regulation: Rab activation is generally mediated by a guanine exchange factor (GEF), while inactivation
    through hydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP) (By similarity). That Rab is
    activated by the DENND4C guanine exchange factor (GEF)

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity EXP--
    GO:0005515protein binding ----
    GO:0005525GTP binding IDA--
    GO:0019003GDP binding IDA--
    GO:0031489myosin V binding IPI--
         
    RAB10 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RAB10:
     Decreased G3BP1 protein expres 

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidRAB10 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RAB10 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Membrane Trafficking
    Translocation of GLUT4 to the Plasma Membrane0.32
    Membrane Trafficking0.32
    2Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions0.36
    3Cytoskeletal Signaling
    Cytoskeletal Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RAB10
        Epithelial Tight Junctions

    1 Cell Signaling Technology (CST) Pathway for RAB10
        Cytoskeletal Signaling

    2        Reactome Pathways for RAB10
        Membrane Trafficking
    Translocation of GLUT4 to the Plasma Membrane



    RAB10 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAB10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/43 Interacting proteins for RAB10 (P610262, 3 ENSP000002647104) via UniProtKB, MINT, STRING, and/or I2D (see all 43)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENOPH1Q9UHY72, 3, ENSP000002739204MINT-8267731 I2D: score=2 STRING: ENSP00000273920
    RIMS1Q86UR53, ENSP000002648394I2D: score=4 STRING: ENSP00000264839
    AP1S1P619663, ENSP000003366664I2D: score=2 STRING: ENSP00000336666
    AURKAO149653, ENSP000002169114I2D: score=2 STRING: ENSP00000216911
    DOK2O604963, ENSP000002764204I2D: score=2 STRING: ENSP00000276420
    About this table

    Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process EXP--
    GO:0006886intracellular protein transport ----
    GO:0006893Golgi to plasma membrane transport ISS--
    GO:0006913nucleocytoplasmic transport ----
    GO:0007165signal transduction ----

    RAB10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RAB10

    Search CenterWatch for drugs/clinical trials and news about RAB10

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RAB10 gene: 
    NM_016131.4  

    Unigene Cluster for RAB10:

    RAB10, member RAS oncogene family
    Hs.467960  [show with all ESTs]
    Unigene Representative Sequence: NM_016131
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000495146 ENST00000264710(uc002rgv.3) ENST00000462003 ENST00000473035

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    Additional mRNA sequence: 

    AF086917.1 AF091032.1 AF106681.1 AF297660.1 AF498945.1 AK023223.1 AK025136.1 AL136650.1 
    BC000896.1 CR457303.1 

    23 DOTS entries:

    DT.419913  DT.95351212  DT.100845459  DT.92455495  DT.100845450  DT.100845453  DT.70102743  DT.95282215 
    DT.100774101  DT.100845452  DT.100845458  DT.100845456  DT.120977613  DT.120977629  DT.120977685  DT.40249961 
    DT.92455457  DT.92455488  DT.95373709  DT.100696537  DT.91945989  DT.95373710  DT.95373712 

    24/614 AceView cDNA sequences (see all 614):

    BQ002826 AW468983 AI422405 BE896006 AA788583 BM982179 F13414 AI026955 
    BE082191 AV703271 BX113781 AI929816 BG435075 BQ636946 CB164497 AW129548 
    BE856775 AA304546 CA313647 AA885611 AI288253 AA314149 AA614147 T34846 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RAB10    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b
    SP1:              -                       -                                             
    SP2:                                                                                    
    SP3:                          -     -     -                                             
    SP4:                                                                                    
    SP5:                                                                                    


    ECgene alternative splicing isoforms for RAB10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RAB10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTTTTATTT
    RAB10 Expression
    About this image


    See RAB10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RAB10

    SOURCE GeneReport for Unigene cluster: Hs.467960
        SABiosciences Custom PCR Arrays for RAB10
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RAB10 gene from 7/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rab101 , 5 RAB10, member RAS oncogene family1, 5 95.33(n)1
    100(a)1
      12 (1.71 cM)5
    193251  NM_016676.51  NP_057885.11 
     32474305 
    chicken
    (Gallus gallus)
    Aves RAB101 RAB10, member RAS oncogene family 89(n)
    98(a)
      421994  NM_001031097.1  NP_001026268.1 
    lizard
    (Anolis carolinensis)
    Reptilia RAB106
    Uncharacterized protein
    73(a)
    1 ↔ 1
    GL344199.1(1650-23448)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC686292 hypothetical protein MGC68629 85.6(n)    BC060015.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rab101 RAB10, member RAS oncogene family 84.33(n)
    96.5(a)
      436839  NM_001002566.1  NP_001002566.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rab101 , 3 Rho small monomeric GTPase3
    Rab-protein 101
    79(a)
    (best of 3)3
    69.87(n)1
    82.32(a)1
      19C13
    330251  NM_078695.21  NP_523419.11 
    worm
    (Caenorhabditis elegans)
    Secernentea rab-83
    rab-101
    RAS-related protein3
    Protein RAB-101
    69(a)
    (best of 2)3
    69.9(n)1
    78.86(a)1
      I(3683002-3684079)3
    2668361  NM_059456.31  NP_491857.11 


    ENSEMBL Gene Tree for RAB10 (if available)
    TreeFam Gene Tree for RAB10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RAB10 gene
    RAB3B2  RAB27B2  RAB8A2  RAB3D2  RAB3A2  RAB27A2  RAB8B2  RAB352  
    RAB1B2  RAB122  RAB1A2  RAB132  RAB3C2  
    18/99 SIMAP similar genes for RAB10 using alignment to 4 protein entries:     RAB10_HUMAN (see all proteins) (see all similar genes):
    RAB8B    rab1b    RAB8A    RAB13    DKFZp686J06205    RAB15
    RAB3A    RAB1C    RAB12    DKFZp686J07132    RAB1A    RAB3C
    RAB19    RAB3B    RAB43    RAB30    RAB37    RAB35

    RAB10 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1953 SNPs in RAB10 are shown (see all 1953)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs709501711,2
    C--26083651(+) TTTTT-/T/TTT 
            
    GAGAC
    1 -- int11NA 2
    rs713993541,2
    C--26228522(+) TCTCC-/A/AA  
            
    AAAAA
    1 -- int11NA 2
    rs1170153901,2
    C,F--26254745(+) GATTTG/ACATAG 1 -- us2k11Minor allele frequency- A:0.04EA 120
    rs1443107631,2
    C--26254774(+) GTTATC/TATCAT 1 -- us2k10--------
    rs1896670881,2
    --26254790(+) ATTCCC/TGACTA 1 -- us2k10--------
    rs1510282531,2
    --26254844(+) CAGGCG/TCAGTG 1 -- us2k10--------
    rs1806815391,2
    --26254868(+) ATCCCA/GGCACT 1 -- us2k10--------
    rs1162618401,2
    F--26255210(+) AAGGAC/AGCTTT 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1148144311,2
    F--26255243(+) AAAATG/ATAAGA 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1836397831,2
    --26255256(+) GAAATA/GTAAGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RAB10 (26256729 - 26360323 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for RAB10:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv508717CNV Loss20534489
    esv33316CNV Loss17666407
    nsv873746CNV Gain21882294
    nsv873747CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612672    OMIM disorders: --

    3 diseases for RAB10:    About MalaCards
    psoriasis    insulin resistance    neuronitis


    RAB10 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RAB10
    Human Genome Epidemiology (HuGE) Navigator: RAB10 (1 document)

    Export disorders for RAB10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RAB10 gene, integrated from 9 sources (see all 49):
    (articles sorted by number of sources associating them with RAB10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Rab10 GTPase regulates ER dynamics and morphology. (PubMed id 23263280)1, 2 English A.R. and Voeltz G.K. (2012)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. Rab10 regulates membrane transport through early endosomes of polarized Madin-Darby canine kidney cells. (PubMed id 16641372)1, 2 Babbey C.M.... Dunn K.W. (2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    7. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (2000)
    8. Expression and localization of two low molecular weight GTP-binding proteins, Rab8 and Rab10, by epitope tag. (PubMed id 7688123)1, 3 Chen Y.T....Moore H.P. (1993)
    9. VCP phosphorylation-dependent interaction partners pre vent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (2013)
    10. Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. (PubMed id 23319000)1 Luykx J.J....Ophoff R.A. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10890 HGNC: 9759 AceView: RAB10 Ensembl:ENSG00000084733 euGenes: HUgn10890
    ECgene: RAB10 H-InvDB: RAB10

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RAB10 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAB10 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RAB10 gene:
    Search GeneIP for patents involving RAB10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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