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Aliases & Descriptions for RAB10
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| | | Descriptions |
|---|
| GTP-binding protein RAB10 2 | | RAB10, member RAS oncogene family 2 | | ras-related GTP-binding protein 2 | | ras-related GTP-binding protein RAB10 2 |
|
| | Search outside databases for aliases for RAB10 genePrevious GC identifers: GC02P026178 GC02P026349 GC02P026231 |
Summaries for RAB10(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for RAB10: RAB10 belongs to the RAS (see HRAS; MIM 190020) superfamily of small GTPases. RAB proteins localize to exocytic and endocytic compartments and regulate intracellular vesicle trafficking (Bao et al., 1998 [PubMed 9918381]).[supplied by OMIM] UniProtKB/Swiss-Prot: RAB10_HUMAN, P61026Function: May be involved in vesicular trafficking and neurotransmitter releaseGene Wiki entry for RAB10 |
Genomic Location for RAB10
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the RAB10 gene 
Entrez Gene cytogenetic band: 2p23.3 Ensembl cytogenetic band: 2p23.3 HGNC cytogenetic band: 2p23.3RAB10 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P026168:
(about GC identifiers)
Start:
|
26,110,478 bp from pter |
End:
|
26,213,782 bp from pter |
Size:
|
103,305 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000002.10 NT_022184.14
| Proteins for RAB10
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: RAB10_HUMAN, P61026 (See
protein sequence)Recommended Name: Ras-related protein Rab-10 Size: 200 amino acids; 22541 Da
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
Secondary accessions: O88386 Q6IA52 Q9D7X6 Q9H0T3Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_057215.2
ENSEMBL proteins: ENSP00000264710
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: RAB10 
2 Gene Ontology (GO) cellular component terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005794 | Golgi apparatus |
IEA | -- | | GO:0005886 | plasma membrane |
IEA | -- | About this table
Antibodies for RAB10: Assays for RAB10: | Protein
Domains/ Families for RAB10(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P61026
ProtoNet protein and cluster: P61026 4 Blocks protein families: IPB002041 GTP-binding nuclear protein Ran IPB003577 Ras small GTPase IPB003578 Ras small GTPase IPB006688 ADP-ribosylation factor
UniProtKB/Swiss-Prot: RAB10_HUMAN, P61026Similarity: Belongs to the small GTPase superfamily. Rab family | Gene Function for RAB10
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_016131
Applied Biosystems Silencer® siRNAs for RAB10
Sigma-Aldrich siRNA for RAB10  Sigma-Aldrich shRNA for RAB10  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_016131                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_016131                                  untagged cDNA clones in CMV expression vector (see all 2): NM_016131 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_016131
UniProtKB/Swiss-Prot: RAB10_HUMAN, P61026Function: May be involved in vesicular trafficking and neurotransmitter release3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for RAB10
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for RAB10 
5 Interacting proteins for RAB10 (P610261, 2) via UniProtKB, MINT, and/or STRINGAbout this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007264 | small GTPase mediated signal transduction |
IEA | -- | | GO:0015031 | protein transport |
IEA | -- | About this table
|
Drugs & Compounds for RAB10(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|  |
Enzo Life Sciences drugs & compounds for RAB10 |
Browse Tocris compounds for RAB10
|
Transcripts for RAB10(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_016131
Sigma-Aldrich siRNA for RAB10  Sigma-Aldrich shRNA for RAB10  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_016131 REFSEQ mRNAs for RAB10 gene: NM_016131.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_016131               OriGene GFP tagged cDNA clone in CMV expression vector: NM_016131                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_016131                                  untagged cDNA clones in CMV expression vector (see all 2): NM_016131  Additional cDNA sequence: AF086917.1 AF091032.1 AF106681.1 AF297660.1 AF498945.1 AK023223.1 AK025136.1 AL136650.1 BC000896.1 CR457303.1 CR606343.1 CR606383.1 CR615601.1 CR623312.1 23 DOTS entries: DT.419913 DT.95351212 DT.100845459 DT.92455495 DT.100845450 DT.100845453 DT.70102743 DT.95282215 DT.100774101 DT.100845452 DT.100845458 DT.100696537 DT.100845456 DT.120977613 DT.120977629 DT.120977685 DT.40249961 DT.92455457 DT.92455488 DT.95373709 DT.91945989 DT.95373710 DT.95373712 24/614 AceView cDNA sequences (see all 614
):BE551250 AA788583 CR623312 AA039234 AI337889 AA298218 CB054153 BU194807 AI753336 BE856775 AA614147 AI523512 AW352202 BX113781 BM458108 CA309038 AV703271 AV653945 AI929816 AW129548 AI288253 AA360801 CR615601 BM741900
highest scoring ESTs for RAB10:AI979258 AA004503 AA004504 AA037328 AA039234 AA039341 AA040197 AA040842 AA064719 AA069181 Unigene Cluster for RAB10: RAB10, member RAS oncogene family Hs.467960 [show with all ESTs]Unigene Representative Sequence: AK023223
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for RAB10
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | |
| SP1: | |   | |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for RAB10
1 Ensembl transcript including schematic representation: ENST00000264710
|
Expression for RAB10
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| RAB10 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for RAB10
1 / 2 / 3 6 probe-sets matching RAB10 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.467960
|
Orthologs for RAB10
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for RAB10 gene from 5/13 species (see all 13
)
About this table Species with no ortholog for RAB10
ENSEMBL Gene Tree for RAB10 | Paralogs for RAB10(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for RAB10 gene
- RAB8B2 RAB8A2
|
SNPs/Variants for RAB10(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for RAB10 (up to first 250kb)
|
Disorders & Mutations for RAB10
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 612672
|
Medical News for RAB10(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for RAB10 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/14 PubMed articles for RAB10 gene (see all 14
):- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)3, 4 Wiemann S.... Poustka A. (2001)
- Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)3, 4 Hu R.-M.... Chen J.-L. (2000)
- Expression and localization of two low molecular weight GTP-binding proteins, Rab8 and Rab10, by epitope tag. (PubMed id 7688123)2, 3 Chen Y.T....Moore H.P. (1993)
- Alternative splicing in class v myosins determines association with rab10. (PubMed id 19008234)3 Roland J.T....Goldenring J.R. (2009)
- Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)3 Ewing R.M....Figeys D. (2007)
- Identification and characterization of a novel, psoriasis susceptibility-related noncoding RNA gene, PRINS. (PubMed id 15855153)3 Sonkoly E....Szell M. (2005)
- Characterization of the role of the Rab GTPase-activating protein AS160 in insulin-regulated GLUT4 trafficking. (PubMed id 16154996)3 Larance M....James D.E. (2005)
- Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2. (PubMed id 12578829)3 Fukuda M. (2003)
|
Search for RAB10
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing RAB10
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing RAB10
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RAB10(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for RAB10(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for RAB10:

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