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RAB10 Gene

protein-coding   GIFtS: 61
GCID: GC02P026256

RAB10, Member RAS Oncogene Family

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RAB10, Member RAS Oncogene Family1 2
Ras-Related GTP-Binding Protein1 2
GTP-Binding Protein RAB102
Ras-Related Protein Rab-102

External Ids:    HGNC: 97591   Entrez Gene: 108902   Ensembl: ENSG000000847337   OMIM: 6126725   UniProtKB: P610263   

Export aliases for RAB10 gene to outside databases

Previous GC identifers: GC02P026178 GC02P026349 GC02P026231 GC02P026168 GC02P025993


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RAB10 Gene:
RAB10 belongs to the RAS (see HRAS; MIM 190020) superfamily of small GTPases. RAB proteins localize to exocytic
and endocytic compartments and regulate intracellular vesicle trafficking (Bao et al., 1998 (PubMed
9918381)).(supplied by OMIM, Mar 2009)

GeneCards Summary for RAB10 Gene:
RAB10 (RAB10, member RAS oncogene family) is a protein-coding gene. GO annotations related to this gene include myosin V binding and GTP binding. An important paralog of this gene is RAB3B.

UniProtKB/Swiss-Prot: RAB10_HUMAN, P61026
Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of
transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active
GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible
for vesicle formation, movement, tethering and fusion (By similarity). That Rab is mainly involved in the
biosynthetic transport of proteins from the Golgi to the plasma membrane. Regulates, for instance, SLC2A4/GLUT4
glucose transporter-enriched vesicles delivery to the plasma membrane. In parallel, it regulates the transport of
TLR4, a toll-like receptor to the plasma membrane and therefore may be important for innate immune response.
Plays also a specific role in asymmetric protein transport to the plasma membrane within the polarized neuron and
epithelial cells. In neurons, it is involved in axonogenesis through regulation of vesicular membrane trafficking
toward the axonal plasma membrane while in epithelial cells, it regulates transport from the Golgi to the
basolateral membrane. Moreover, may play a role in the basolateral recycling pathway and in phagosome maturation.
According to PubMed:23263280, may play a role in endoplasmic reticulum dynamics and morphology controlling
tubulation along microtubules and tubules fusion

Gene Wiki entry for RAB10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_022184.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the RAB10 gene promoter:
         Pax-5   p300   Olf-1   IRF-1   HNF-3beta   AP-2gamma   E47   Egr-2   FOXO4   Hand1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RAB10 promoter sequence
   Search Chromatin IP Primers for RAB10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RAB10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23.3   Ensembl cytogenetic band:  2p23.3   HGNC cytogenetic band: 2p23.3

RAB10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAB10 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P026256:  view genomic region     (about GC identifiers)

Start:
26,256,729 bp from pter      End:
26,360,323 bp from pter
Size:
103,595 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RAB10_HUMAN, P61026 (See protein sequence)
Recommended Name: Ras-related protein Rab-10  
Size: 200 amino acids; 22541 Da
Subunit: Interacts with MYO5A; mediates the transport to the plasma membrane of SLC2A4/GLUT4 storage vesicles.
Interacts with GDI1 and maybe with GDI2; negatively regulates RAB10 association with membranes and activation.
Interacts (GDP-bound form) with LLGL1; the interaction is direct and promotes RAB10 association with membranes
and activation through competition with the Rab inhibitor GDI1 (By similarity). Interacts with EXOC4; probably
associates with the exocyst (By similarity)
Secondary accessions: D6W538 O88386 Q6IA52 Q9D7X6 Q9H0T3

Explore the universe of human proteins at neXtProt for RAB10: NX_P61026

Explore proteomics data for RAB10 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys102
  • Modification sites at PhosphoSitePlus

  • See RAB10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057215.3  
    ENSEMBL proteins: 
     ENSP00000264710  
    Reactome Protein details: P61026

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RAB: RAB, member RAS oncogene

    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR003579 Small_GTPase_Rab_type
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry P61026

    ProtoNet protein and cluster: P61026

    4 Blocks protein domains:
    IPB002041 GTP-binding nuclear protein Ran
    IPB003577 Ras small GTPase
    IPB003578 Ras small GTPase
    IPB006688 ADP-ribosylation factor


    UniProtKB/Swiss-Prot: RAB10_HUMAN, P61026
    Similarity: Belongs to the small GTPase superfamily. Rab family


    Find genes that share domains with RAB10           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RAB10_HUMAN, P61026
    Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of
    transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active
    GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible
    for vesicle formation, movement, tethering and fusion (By similarity). That Rab is mainly involved in the
    biosynthetic transport of proteins from the Golgi to the plasma membrane. Regulates, for instance, SLC2A4/GLUT4
    glucose transporter-enriched vesicles delivery to the plasma membrane. In parallel, it regulates the transport of
    TLR4, a toll-like receptor to the plasma membrane and therefore may be important for innate immune response.
    Plays also a specific role in asymmetric protein transport to the plasma membrane within the polarized neuron and
    epithelial cells. In neurons, it is involved in axonogenesis through regulation of vesicular membrane trafficking
    toward the axonal plasma membrane while in epithelial cells, it regulates transport from the Golgi to the
    basolateral membrane. Moreover, may play a role in the basolateral recycling pathway and in phagosome maturation.
    According to PubMed:23263280, may play a role in endoplasmic reticulum dynamics and morphology controlling
    tubulation along microtubules and tubules fusion
    Enzyme regulation: Rab activation is generally mediated by a guanine exchange factor (GEF), while inactivation
    through hydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP) (By similarity). That Rab is
    activated by the DENND4C guanine exchange factor (GEF)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity EXP--
    GO:0005515protein binding ----
    GO:0005525GTP binding IDA--
    GO:0019003GDP binding IDA--
    GO:0031489myosin V binding IPI--
         
    Find genes that share ontologies with RAB10           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for RAB10:
     Decreased G3BP1 protein expres 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for RAB10

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    SwitchGear 3'UTR luciferase reporter plasmidRAB10 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RAB10_HUMAN, P61026: Cytoplasmic vesicle membrane; Lipid-anchor (Probable); Cytoplasmic side (Probable). Golgi
    apparatus, trans-Golgi network membrane (By similarity). Endosome membrane. Recycling endosome membrane.
    Cytoplasmic vesicle, phagosome membrane (By similarity). Cell projection, cilium. Endoplasmic reticulum membrane.
    Note=Associates with SLC2A4/GLUT4 storage vesicles. Localizes to the base of the cilium. Transiently associates
    with phagosomes (By similarity). According to PubMed:23263280 localizes to the endoplasmic reticulum at domains
    of new tubule growth
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    endosome5
    golgi apparatus5
    cytosol2
    mitochondrion2
    plasma membrane2
    cytoskeleton1

    Gene Ontology (GO): Selected cellular component terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000145colocalizes with exocyst ISS--
    GO:0005622intracellular ----
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0005768endosome IDA--

    Find genes that share ontologies with RAB10           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RAB10 About    
    See pathways by source

    SuperPathContained pathways About
    1Clathrin derived vesicle budding
    Membrane Trafficking0.32
    Translocation of GLUT4 to the Plasma Membrane0.32
    2Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions0.36
    3Cytoskeletal Signaling
    Cytoskeletal Signaling


    Find genes that share SuperPaths with RAB10           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for RAB10
        Epithelial Tight Junctions

    1 Cell Signaling Technology (CST) Pathway for RAB10
        Cytoskeletal Signaling


    1 Reactome Pathway for RAB10
        Translocation of GLUT4 to the plasma membrane


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RAB10
    Interactions:

        GeneGlobe Interaction Network for RAB10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RAB10 (P610262, 3 ENSP000002647104) via UniProtKB, MINT, STRING, and/or I2D (see all 110)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENOPH1Q9UHY72, 3, ENSP000002739204MINT-8267731 I2D: score=2 STRING: ENSP00000273920
    RIMS1Q86UR53, ENSP000002648394I2D: score=4 STRING: ENSP00000264839
    AP1S1P619663, ENSP000003366664I2D: score=2 STRING: ENSP00000336666
    AURKAO149653, ENSP000002169114I2D: score=2 STRING: ENSP00000216911
    DOK2O604963, ENSP000002764204I2D: score=2 STRING: ENSP00000276420
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process EXP--
    GO:0006886intracellular protein transport ----
    GO:0006893Golgi to plasma membrane transport ISS--
    GO:0006913nucleocytoplasmic transport ----
    GO:0007165signal transduction ----

    Find genes that share ontologies with RAB10           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for RAB10



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RAB10 gene: 
    NM_016131.4  

    Unigene Cluster for RAB10:

    RAB10, member RAS oncogene family
    Hs.467960  [show with all ESTs]
    Unigene Representative Sequence: NM_016131
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000495146 ENST00000264710(uc002rgv.3) ENST00000462003 ENST00000473035

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    Additional mRNA sequence: 

    AF086917.1 AF091032.1 AF106681.1 AF297660.1 AF498945.1 AK023223.1 AK025136.1 AL136650.1 
    BC000896.1 CR457303.1 

    23 DOTS entries:

    DT.419913  DT.95351212  DT.100845459  DT.92455495  DT.100845450  DT.100845453  DT.70102743  DT.95282215 
    DT.100774101  DT.100845452  DT.100845458  DT.100845456  DT.120977613  DT.120977629  DT.120977685  DT.40249961 
    DT.92455457  DT.92455488  DT.95373709  DT.100696537  DT.91945989  DT.95373710  DT.95373712 

    Selected AceView cDNA sequences (see all 614):

    CR623312 BM674597 AI422405 AI421503 AI026955 CB136395 CB045250 BG390246 
    AA360801 BM458108 AW129548 AA569014 BQ636946 AA885611 AW352202 F13414 
    AA788583 AI753213 BX502575 AA251429 T34846 AI523512 AI624929 BX113781 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RAB10    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b
    SP1:              -                       -                                             
    SP2:                                                                                    
    SP3:                          -     -     -                                             
    SP4:                                                                                    
    SP5:                                                                                    


    ECgene alternative splicing isoforms for RAB10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RAB10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTTTTATTT
    RAB10 Expression
    About this image


    RAB10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Colon (Gastrointestinal Tract)
     
     Kidney (Urinary System)
     
     Uterus (Reproductive System)
     
     Lung (Respiratory System)
    RAB10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RAB10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.467960
        Custom PCR Arrays for RAB10
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAB10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RAB10 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rab101 , 5 RAB10, member RAS oncogene family1, 5 95.33(n)1
    100(a)1
      12 (1.71 cM)5
    193251  NM_016676.51  NP_057885.11 
     32474305 
    chicken
    (Gallus gallus)
    Aves RAB101 RAB10, member RAS oncogene family 89(n)
    98(a)
      421994  NM_001031097.1  NP_001026268.1 
    lizard
    (Anolis carolinensis)
    Reptilia RAB106
    RAB10, member RAS oncogene family
    76(a)
    1 ↔ 1
    GL344199.1(1650-23448)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC686292 hypothetical protein MGC68629 85.6(n)    BC060015.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rab101 RAB10, member RAS oncogene family 84.33(n)
    96.5(a)
      436839  NM_001002566.1  NP_001002566.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rab101 , 3 Rho small monomeric GTPase3
    Rab101
    79(a)
    (best of 3)3
    69.68(n)1
    82.41(a)1
      19C13
    330251  NM_078695.21  NP_523419.11 
    worm
    (Caenorhabditis elegans)
    Secernentea rab-83
    rab-101
    RAS-related protein3
    rab-101
    69(a)
    (best of 2)3
    69.9(n)1
    78.86(a)1
      I(3683002-3684079)3
    2668361  NM_059456.41  NP_491857.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons RABE1e1 RABE1e 61.81(n)
    60.8(a)
      820148  NM_111825.3  NP_187601.1 


    ENSEMBL Gene Tree for RAB10 (if available)
    TreeFam Gene Tree for RAB10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RAB10 gene
    RAB3B2  RAB262  RAB8A2  RAB3D2  RAB372  RAB3A2  RAB8B2  RAB1B2  
    RAB122  RAB1A2  RAB132  RAB3C2  
    Selected SIMAP similar genes for RAB10 using alignment to 4 protein entries:     RAB10_HUMAN (see all proteins) (see all similar genes):
    RAB8B    rab1b    RAB8A    RAB13    DKFZp686J06205    RAB15
    RAB1C    RAB12    DKFZp686J07132    RAB1A    RAB3C    RAB3A
    RAB19    RAB3B    RAB43    RAB30    RAB37    RAB35

    Find genes that share paralogs with RAB10           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RAB10 (see all 1953)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs709501711,2
    C--26083651(+) TTTTT-/T/TTT 
            
    GAGAC
    1 -- int11NA 2
    rs713993541,2
    C--26228522(+) TCTCC-/A/AA  
            
    AAAAA
    1 -- int11NA 2
    rs1170153901,2
    C,F--26254745(+) GATTTG/ACATAG 1 -- us2k11Minor allele frequency- A:0.04EA 120
    rs1443107631,2
    C--26254774(+) GTTATC/TATCAT 1 -- us2k10--------
    rs1896670881,2
    --26254790(+) ATTCCC/TGACTA 1 -- us2k10--------
    rs1510282531,2
    --26254844(+) CAGGCG/TCAGTG 1 -- us2k10--------
    rs1806815391,2
    --26254868(+) ATCCCA/GGCACT 1 -- us2k10--------
    rs1162618401,2
    F--26255210(+) AAGGAC/AGCTTT 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1148144311,2
    F--26255243(+) AAAATG/ATAAGA 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1836397831,2
    --26255256(+) GAAATA/GTAAGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RAB10 (26256729 - 26360323 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for RAB10:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508717CNV Loss20534489
    esv33316CNV Loss17666407
    nsv873746CNV Gain21882294
    nsv873747CNV Gain21882294

    Human Gene Mutation Database (HGMD): RAB10
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RAB10
    DNA2.0 Custom Variant and Variant Library Synthesis for RAB10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612672    OMIM disorders: --


    Find genes that share disorders with RAB10           About GenesLikeMe

    Genetic Association Database (GAD): RAB10
    Human Genome Epidemiology (HuGE) Navigator: RAB10 (1 document)

    Export disorders for RAB10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RAB10 gene, integrated from 10 sources (see all 52):
    (articles sorted by number of sources associating them with RAB10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Rab10 GTPase regulates ER dynamics and morphology. (PubMed id 23263280)1, 2 English A.R. and Voeltz G.K. (Nat. Cell Biol. 2012)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Rab10 regulates membrane transport through early endosomes of polarized Madin-Darby canine kidney cells. (PubMed id 16641372)1, 2 Babbey C.M.... Dunn K.W. (Mol. Biol. Cell 2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    7. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    8. Expression and localization of two low molecular weight GTP-binding proteins, Rab8 and Rab10, by epitope tag. (PubMed id 7688123)1, 3 Chen Y.T....Moore H.P. (Proc. Natl. Acad. Sci. U.S.A. 1993)
    9. VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (PLoS ONE 2013)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10890 HGNC: 9759 AceView: RAB10 Ensembl:ENSG00000084733 euGenes: HUgn10890
    ECgene: RAB10 H-InvDB: RAB10

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RAB10 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAB10 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RAB10 gene:
    Search GeneIP for patents involving RAB10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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