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RAB10 Gene

protein-coding   GIFtS: 54

GC02P026168
RAB10, member RAS oncogene family
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Descriptions
GTP-binding protein RAB10 2
RAB10, member RAS oncogene family 2
ras-related GTP-binding protein 2
ras-related GTP-binding protein RAB10 2
External Ids
HGNC: 97591
Entrez Gene: 108902
UniProtKB: P610263
Ensembl: ENSG000000847337
Search outside databases for aliases for RAB10 gene

Previous GC identifers: GC02P026178 GC02P026349 GC02P026231

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for RAB10:
RAB10 belongs to the RAS (see HRAS; MIM 190020) superfamily of small GTPases. RAB proteins localize
to exocytic and endocytic compartments and regulate intracellular vesicle trafficking (Bao et al.,
1998 [PubMed 9918381]).[supplied by OMIM]

UniProtKB/Swiss-Prot: RAB10_HUMAN, P61026
Function: May be involved in vesicular trafficking and neurotransmitter release

Gene Wiki entry for RAB10

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the RAB10 gene  

Entrez Gene cytogenetic band: 2p23.3   Ensembl cytogenetic band:  2p23.3   HGNC cytogenetic band: 2p23.3

RAB10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P026168:     (about GC identifiers)

Start:
26,110,478 bp from pter
End:
26,213,782 bp from pter
Size:
103,305 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000002.10  NT_022184.14  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: RAB10_HUMAN, P61026 (See protein sequence)
Recommended Name: Ras-related protein Rab-10  
Size: 200 amino acids; 22541 Da
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
Secondary accessions: O88386 Q6IA52 Q9D7X6 Q9H0T3

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_057215.2  

    ENSEMBL proteins: 
    ENSP00000264710 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Sigma-Aldrich AQUA Peptides for RAB10  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (RAB10)
    Human Recombinant Proteins from Abnova (RAB10)
                  OriGene Purified Recombinant Human Protein: RAB10 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005794 Golgi apparatus IEA--
    GO:0005886 plasma membrane IEA--
    About this table

    Antibodies for RAB10: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for RAB10
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (RAB10), each with their AbpromiseSM
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for RAB10

    Assays for RAB10: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    4 InterPro domains/families:
     IPR001806 Ras_GTPase
     IPR005225 Small_GTP_bd
     IPR003579 GTPase_Rab
     IPR013753 Ras


       GeneDecks  RAB10 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P61026

    ProtoNet protein and cluster: P61026

    4 Blocks protein families:
    IPB002041 GTP-binding nuclear protein Ran
    IPB003577 Ras small GTPase
    IPB003578 Ras small GTPase
    IPB006688 ADP-ribosylation factor


    UniProtKB/Swiss-Prot: RAB10_HUMAN, P61026
    Similarity: Belongs to the small GTPase superfamily. Rab family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (RAB10)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_016131

                  Applied Biosystems Silencer® siRNAs for RAB10

                  Sigma-Aldrich siRNA for RAB10  
                         Sigma-Aldrich shRNA for RAB10  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_016131
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_016131
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_016131 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_016131

    UniProtKB/Swiss-Prot: RAB10_HUMAN, P61026
    Function: May be involved in vesicular trafficking and neurotransmitter release

    3 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0005515 protein binding IPI17353931
    GO:0005525 GTP binding IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


     Gene Network CentralTM Interacting Genes and Proteins Network for  RAB10 


    5 Interacting proteins for RAB10 (P610261, 2) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AP1S1P619661EBI-726075, EBI-516199
    AURKAO149651EBI-726075, EBI-448680
    DOK2O604961EBI-726075, EBI-1046024
    RAB8AP610061EBI-726075, EBI-722293
    --Q9HC742MINT-65558
    About this table

    2 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007264 small GTPase mediated signal transduction IEA--
    GO:0015031 protein transport IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Enzo Life Sciences drugs & compounds for RAB10
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for RAB10

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (RAB10)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_016131

                  Sigma-Aldrich siRNA for RAB10  
                         Sigma-Aldrich shRNA for RAB10  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_016131  

    REFSEQ mRNAs for RAB10 gene: 

    NM_016131.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_016131  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_016131
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_016131
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_016131 

    Additional cDNA sequence: 

    AF086917.1 AF091032.1 AF106681.1 AF297660.1 AF498945.1 AK023223.1 AK025136.1 AL136650.1 
    BC000896.1 CR457303.1 CR606343.1 CR606383.1 CR615601.1 CR623312.1 

    23 DOTS entries:

    DT.419913  DT.95351212  DT.100845459  DT.92455495  DT.100845450  DT.100845453  DT.70102743  DT.95282215 
    DT.100774101  DT.100845452  DT.100845458  DT.100696537  DT.100845456  DT.120977613  DT.120977629  DT.120977685 
    DT.40249961  DT.92455457  DT.92455488  DT.95373709  DT.91945989  DT.95373710  DT.95373712 

    24/614 AceView cDNA sequences (see all 614 ):

    BE551250 AA788583 CR623312 AA039234 AI337889 AA298218 CB054153 BU194807 
    AI753336 BE856775 AA614147 AI523512 AW352202 BX113781 BM458108 CA309038 
    AV703271 AV653945 AI929816 AW129548 AI288253 AA360801 CR615601 BM741900 

    highest scoring ESTs for RAB10:

    AI979258 AA004503 AA004504 AA037328 AA039234 AA039341 AA040197 AA040842 AA064719 AA069181 

    Unigene Cluster for RAB10:

    RAB10, member RAS oncogene family
    Hs.467960  [show with all ESTs]
    Unigene Representative Sequence: AK023223


    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RAB10

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b
    SP1:              -                       -                                             
    SP2:                                                                                    
    SP3:                          -     -     -                                             
    SP4:                                                                                    
    SP5:                                                                                    

    About this scheme

    ECgene alternative splicing isoforms for RAB10

    1 Ensembl transcript including schematic representation:
    ENST00000264710  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    RAB10 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for RAB10

    1 / 2 / 3

    6 probe-sets matching RAB10 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    52273_s_at2, 3 U95-B 1 1.00 1.00 0.94 1.14 AI979258 1.00 1.00 1.00 1

    49068_at2, 3 U95-C 1 0.81 1.00 0.93 0.86 AI031674 0.80 1.00 0.91 1

    222980_at2, 3 U133-B 1 1.00 1.00 -- -- AL136650 0.80 0.88 0.84 1

    222981_s_at2, 3 U133-B 1 1.00 1.00 -- -- BC000896 0.80 0.88 0.84 1

    222980_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    222981_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.467960
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for RAB10 gene from 5/13 species (see all 13 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    RAB101   -- RAB10, member RAS oncogene family 97(n)
    99.5(a)
    403958  XM_850497.1  XP_855590.1 
    chimpanzee
    (Pan troglodytes)
    RAB101   -- RAB10, member RAS oncogene family 95.5(n)
    94.5(a)
    470332  XM_001149926.1  XP_001149926.1 
    cow
    (Bos taurus)
    RAB101   -- RAB10, member RAS oncogene family 96.5(n)
    99.5(a)
    783373  XM_001251776.1  XP_001251777.1 
    rat
    (Rattus norvegicus)
    Rab101   -- RAB10, member RAS oncogene family 95(n)
    99.5(a)
    50993  NM_017359.2  NP_059055.2 
    mouse
    (Mus musculus)
    Rab101, 5 12 (2.00 cM)5
    RAB10, member RAS oncogene family1, 5 95(n)1
    99.5(a)1
    193251  NM_016676.41  NP_057885.11 
     AB2326045  AF0356465  (see all 41)
    About this table        Species with no ortholog for RAB10

    ENSEMBL Gene Tree for RAB10
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for RAB10 gene
    RAB8B2  RAB8A2  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/537 NCBI SNPs in RAB10 are shown (see all 537 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 115)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 2 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs67051,2
    A,C,F,H,O26211614(-) ATGAAG/CTCACA 1 -- ut3114Minor allele frequency- C:0.17MN EA NA EU WA 2726
    rs31770551,2
    A,C,F,H,O26212819(+) CCATGA/GGTTTG 1 -- ut317Minor allele frequency- G:0.19NA EU EA WA 560
    rs67498551,2
    A,C,F,H26108767(+) AAGACG/AGAAAT 1 -- ng51 tfbs37Minor allele frequency- A:0.15EU EA WA NA 558
    rs46652981,2
    C,F,H26109882(+) TCCCCA/GTCAGG 1 -- ng517Minor allele frequency- G:0.20NA MN EA EU WA 1582
    rs67390611,2
    C,F,H26109651(+) TTCTCT/CCGGAT 1 -- ng51 tfbs34Minor allele frequency- C:0.21EU EA WA 398
    rs46652991,2
    C,F26110344(+) GAGACC/AGGAGC 1 -- ng515Minor allele frequency- A:0.41NA 324
    --
    rs101685031,2
    C26109495(+) aaaaaA/Gaaaga 1 -- ng51 trp30--------
    rs10433871,2
    F26110906(+) GCCCGA/GGTGAG 1 -- ut51 ese31Minor allele frequency- G:0.02MN 184
    --
    rs46653001,2
    C26110753(+) GCGGAC/GGGGCT 1 -- ut51 ese30--------
    rs133899521,2
    H26214197(+) TCTTAC/TTAAGA 1 -- ng314Minor allele frequency- T:0.00EU EA WA 414
    About this table

    HapMap Linkage Disequilibrium images for RAB10 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 612672

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/14 PubMed articles for RAB10 gene (see all 14 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 10890 HGNC: 9759 AceView: RAB10 Ensembl:ENSG00000084733 euGenes: HUgn10890
    ECgene: RAB10 H-InvDB: RAB10
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for RAB10 Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for RAB10:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
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     Predesigned and custom siRNAs for RAB10 Antibodies for RAB10
     Explore super-pooled esiRNAs Proteins for RAB10
     Lentivirus-delivered shRNAs for RAB10 Browse small molecules at Sigma-Aldrich
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     Purified proteins from HEK293T cells
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     Search Tocris compounds for RAB10




     Drugs for RAB10
     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Search Novus for antibodies for RAB10

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