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Aliases for RAB10 Gene

Aliases for RAB10 Gene

  • RAB10, Member RAS Oncogene Family 2 3
  • Ras-Related GTP-Binding Protein 2

External Ids for RAB10 Gene

Previous GeneCards Identifiers for RAB10 Gene

  • GC02P026178
  • GC02P026349
  • GC02P026231
  • GC02P026168
  • GC02P026256
  • GC02P025993

Summaries for RAB10 Gene

Entrez Gene Summary for RAB10 Gene

  • RAB10 belongs to the RAS (see HRAS; MIM 190020) superfamily of small GTPases. RAB proteins localize to exocytic and endocytic compartments and regulate intracellular vesicle trafficking (Bao et al., 1998 [PubMed 9918381]).[supplied by OMIM, Mar 2009]

GeneCards Summary for RAB10 Gene

RAB10 (RAB10, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Endocytosis and Cytoskeletal Signaling. GO annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB37.

UniProtKB/Swiss-Prot for RAB10 Gene

  • The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane. Regulates, for instance, SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane. In parallel, it regulates the transport of TLR4, a toll-like receptor to the plasma membrane and therefore may be important for innate immune response. Plays also a specific role in asymmetric protein transport to the plasma membrane within the polarized neuron and epithelial cells. In neurons, it is involved in axonogenesis through regulation of vesicular membrane trafficking toward the axonal plasma membrane while in epithelial cells, it regulates transport from the Golgi to the basolateral membrane. Moreover, may play a role in the basolateral recycling pathway and in phagosome maturation. According to PubMed:23263280, may play a role in endoplasmic reticulum dynamics and morphology controlling tubulation along microtubules and tubules fusion.

Gene Wiki entry for RAB10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB10 Gene

Genomics for RAB10 Gene

Regulatory Elements for RAB10 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RAB10 Gene

Chromosome:
2
Start:
26,033,860 bp from pter
End:
26,137,454 bp from pter
Size:
103,595 bases
Orientation:
Plus strand

Genomic View for RAB10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAB10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB10 Gene

Proteins for RAB10 Gene

  • Protein details for RAB10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61026-RAB10_HUMAN
    Recommended name:
    Ras-related protein Rab-10
    Protein Accession:
    P61026
    Secondary Accessions:
    • D6W538
    • O88386
    • Q6IA52
    • Q9D7X6
    • Q9H0T3

    Protein attributes for RAB10 Gene

    Size:
    200 amino acids
    Molecular mass:
    22541 Da
    Quaternary structure:
    • Interacts with MYO5A; mediates the transport to the plasma membrane of SLC2A4/GLUT4 storage vesicles. Interacts with GDI1 and maybe with GDI2; negatively regulates RAB10 association with membranes and activation. Interacts (GDP-bound form) with LLGL1; the interaction is direct and promotes RAB10 association with membranes and activation through competition with the Rab inhibitor GDI1 (By similarity). Interacts with EXOC4; probably associates with the exocyst (By similarity).

neXtProt entry for RAB10 Gene

Proteomics data for RAB10 Gene at MOPED

Post-translational modifications for RAB10 Gene

  • Ubiquitination at Lys 102
  • Modification sites at PhosphoSitePlus

Other Protein References for RAB10 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RAB10 (Rab10)

No data available for DME Specific Peptides for RAB10 Gene

Domains & Families for RAB10 Gene

Gene Families for RAB10 Gene

Suggested Antigen Peptide Sequences for RAB10 Gene

Graphical View of Domain Structure for InterPro Entry

P61026

UniProtKB/Swiss-Prot:

RAB10_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB10: view

Function for RAB10 Gene

Molecular function for RAB10 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Rab activation is generally mediated by a guanine exchange factor (GEF), while inactivation through hydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP) (By similarity). That Rab is activated by the DENND4C guanine exchange factor (GEF).
UniProtKB/Swiss-Prot Function:
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane. Regulates, for instance, SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane. In parallel, it regulates the transport of TLR4, a toll-like receptor to the plasma membrane and therefore may be important for innate immune response. Plays also a specific role in asymmetric protein transport to the plasma membrane within the polarized neuron and epithelial cells. In neurons, it is involved in axonogenesis through regulation of vesicular membrane trafficking toward the axonal plasma membrane while in epithelial cells, it regulates transport from the Golgi to the basolateral membrane. Moreover, may play a role in the basolateral recycling pathway and in phagosome maturation. According to PubMed:23263280, may play a role in endoplasmic reticulum dynamics and morphology controlling tubulation along microtubules and tubules fusion.

Gene Ontology (GO) - Molecular Function for RAB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IBA --
GO:0005515 protein binding IPI 25416956
GO:0005525 GTP binding IDA 20937701
GO:0019003 GDP binding IDA 20937701
GO:0031489 myosin V binding IPI 22908308
genes like me logo Genes that share ontologies with RAB10: view
genes like me logo Genes that share phenotypes with RAB10: view

Animal Model Products

miRNA for RAB10 Gene

miRTarBase miRNAs that target RAB10

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAB10

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB10 Gene

Localization for RAB10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB10 Gene

Cytoplasmic vesicle membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus, trans-Golgi network membrane. Endosome membrane. Recycling endosome membrane. Cytoplasmic vesicle, phagosome membrane. Cell projection, cilium. Endoplasmic reticulum membrane. Note=Associates with SLC2A4/GLUT4 storage vesicles. Localizes to the base of the cilium. Transiently associates with phagosomes (By similarity). According to PubMed:23263280 localizes to the endoplasmic reticulum at domains of new tubule growth. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB10 Gene COMPARTMENTS Subcellular localization image for RAB10 gene
Compartment Confidence
endoplasmic reticulum 5
endosome 5
extracellular 5
golgi apparatus 5
plasma membrane 2
cytoskeleton 1
vacuole 1

Gene Ontology (GO) - Cellular Components for RAB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000145 colocalizes_with exocyst ISS --
GO:0005622 intracellular --
GO:0005768 endosome IDA 20576682
GO:0005789 endoplasmic reticulum membrane IDA 23263280
GO:0005794 Golgi apparatus IDA 23263280
genes like me logo Genes that share ontologies with RAB10: view

Pathways & Interactions for RAB10 Gene

genes like me logo Genes that share pathways with RAB10: view

Pathways by source for RAB10 Gene

1 Qiagen pathway for RAB10 Gene
1 Cell Signaling Technology pathway for RAB10 Gene

Gene Ontology (GO) - Biological Process for RAB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA --
GO:0006893 Golgi to plasma membrane transport ISS --
GO:0006904 vesicle docking involved in exocytosis IBA --
GO:0006913 nucleocytoplasmic transport --
GO:0007165 signal transduction --
genes like me logo Genes that share ontologies with RAB10: view

No data available for SIGNOR curated interactions for RAB10 Gene

Drugs & Compounds for RAB10 Gene

No Compound Related Data Available

Transcripts for RAB10 Gene

mRNA/cDNA for RAB10 Gene

Unigene Clusters for RAB10 Gene

RAB10, member RAS oncogene family:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAB10

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB10 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b
SP1: - -
SP2:
SP3: - - -
SP4:
SP5:

Relevant External Links for RAB10 Gene

GeneLoc Exon Structure for
RAB10
ECgene alternative splicing isoforms for
RAB10

Expression for RAB10 Gene

mRNA expression in normal human tissues for RAB10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB10 Gene

This gene is overexpressed in Esophagus - Mucosa (x4.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAB10 Gene



SOURCE GeneReport for Unigene cluster for RAB10 Gene Hs.467960

genes like me logo Genes that share expression patterns with RAB10: view

Protein tissue co-expression partners for RAB10 Gene

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RAB10 Gene

Orthologs for RAB10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RAB10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RAB10 35
  • 96.83 (n)
  • 100 (a)
RAB10 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAB10 35
  • 97.33 (n)
  • 100 (a)
RAB10 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rab10 35
  • 95.33 (n)
  • 100 (a)
Rab10 16
Rab10 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RAB10 35
  • 99.83 (n)
  • 100 (a)
RAB10 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rab10 35
  • 95.33 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia RAB10 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAB10 36
  • 98 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAB10 35
  • 89 (n)
  • 98 (a)
RAB10 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAB10 36
  • 76 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68629 35
zebrafish
(Danio rerio)
Actinopterygii rab10 35
  • 84.33 (n)
  • 96.5 (a)
rab10 36
  • 96 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG2885 37
  • 44 (a)
Rab10 37
  • 79 (a)
Rab8 37
  • 78 (a)
Rab10 35
  • 69.68 (n)
  • 82.41 (a)
Rab10 36
  • 80 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000671 35
  • 70.69 (n)
  • 79.4 (a)
worm
(Caenorhabditis elegans)
Secernentea 4R79.2 37
  • 37 (a)
rab-8 37
  • 69 (a)
rab-10 35
  • 69.9 (n)
  • 78.86 (a)
rab-10 36
  • 70 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons RABE1e 35
  • 61.81 (n)
  • 60.8 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3286 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 71 (a)
OneToOne
Species with no ortholog for RAB10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RAB10 Gene

ENSEMBL:
Gene Tree for RAB10 (if available)
TreeFam:
Gene Tree for RAB10 (if available)

Paralogs for RAB10 Gene

Paralogs for RAB10 Gene

genes like me logo Genes that share paralogs with RAB10: view

Variants for RAB10 Gene

Sequence variations from dbSNP and Humsavar for RAB10 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs6705 -- 26,135,241(-) ATGAA(C/G)TCACA utr-variant-3-prime
rs750450 -- 26,101,762(+) TACCT(A/G)ACACA intron-variant
rs750451 -- 26,101,372(+) TATGG(A/G)TCTTA intron-variant
rs750452 -- 26,102,126(-) AGATC(C/T)TGCCA intron-variant
rs1043259 -- 26,136,725(+) CCTCT(G/T)GGCTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RAB10 Gene

Variant ID Type Subtype PubMed ID
esv33316 CNV Loss 17666407
nsv873746 CNV Gain 21882294
nsv508717 CNV Loss 20534489
nsv873747 CNV Gain 21882294

Variation tolerance for RAB10 Gene

Residual Variation Intolerance Score: 40.88% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.05; 1.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAB10 Gene

HapMap Linkage Disequilibrium report
RAB10
Human Gene Mutation Database (HGMD)
RAB10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB10 Gene

Disorders for RAB10 Gene

Relevant External Links for RAB10

Genetic Association Database (GAD)
RAB10
Human Genome Epidemiology (HuGE) Navigator
RAB10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAB10
genes like me logo Genes that share disorders with RAB10: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB10 Gene

Publications for RAB10 Gene

  1. Expression and localization of two low molecular weight GTP-binding proteins, Rab8 and Rab10, by epitope tag. (PMID: 7688123) Chen Y.T. … Moore H.P. (Proc. Natl. Acad. Sci. U.S.A. 1993) 2 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  3. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 67
  4. PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry. (PMID: 24332808) Marechal A. … Zou L. (Mol. Cell 2014) 67
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67

Products for RAB10 Gene

Sources for RAB10 Gene

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