R3HDML Gene
protein-coding GIFtS: 38
GCID: GC20P042965
|
|
R3H domain containing-like(Previous name: R3H domain (binds single-stranded nucleic acids) containing-like...)
| |
Aliases
for R3HDML gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| R3H Domain Containing-Like1 2 | | DJ881L22.31 | | R3H Domain (Binds Single-Stranded Nucleic Acids) Containing-Like1 2 | | Cysteine-Rich Secretory Protein R3HDML2 3 | | Peptidase Inhibitor R3HDML2 |
Export aliases for R3HDML gene to outside databasesPrevious GC identifers: GC20U990180 GC20M042654 GC20P043605 GC20P043651 GC20P042399 GC20P039703 |
Summaries
for R3HDML gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: CRSPL_HUMAN, Q9H3Y0Function: Putative serine protease inhibitor (By similarity)
|
Genomic Views
for R3HDML gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011362.10
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the R3HDML gene promoter:
NF-1 Spz1 RP58 AML1a Lmo2 C/EBPalpha Nkx6-1 ATF ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for R3HDML
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat R3HDML |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20q13.12 Ensembl cytogenetic band: 20q13.12 HGNC cytogenetic band: 20q13.12R3HDML Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20P042965: view genomic region
(about GC identifiers)
Start:
|
42,965,626 bp from pter |
End:
|
42,979,875 bp from pter |
Size:
|
14,250 bases |
Orientation:
|
plus strand |
|
Proteins
for R3HDML gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CRSPL_HUMAN, Q9H3Y0 (See
protein sequence)Recommended Name: Peptidase inhibitor R3HDML precursor Size: 253 amino acids; 28605 Da
Subcellular location: Secreted (Potential)
Caution: Despite its name, it does not contain a R3H domainExplore the universe of human proteins at neXtProt for R3HDML: NX_Q9H3Y0
R3HDML Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_848586.1
ENSEMBL proteins: ENSP00000217043
Human Recombinant Protein Products for R3HDML:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
R3HDML for ontologies About GeneDecksing
R3HDML Antibody Products:
Assay Products for R3HDML: |
Protein
Domains /
Families
for R3HDML gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
R3HDML for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H3Y0ProtoNet protein and cluster: Q9H3Y0 1 Blocks protein family: IPB001283 Allergen V5/Tpx-1 related
UniProtKB/Swiss-Prot: CRSPL_HUMAN, Q9H3Y0Similarity: Belongs to the CRISP family |
Function
for R3HDML gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: CRSPL_HUMAN, Q9H3Y0Function: Putative serine protease inhibitor (By similarity) Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0030414 | peptidase inhibitor activity |
IEA | -- |
R3HDML for ontologies About GeneDecksing
Phenotypes:
1 MGI phenotypic allele  for R3hdml (no phenotypes)
R3HDML for phenotypes About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for R3HDML (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for R3HDML
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: R3HDML (NM_178491) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for R3HDML | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat R3HDML |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for R3HDML |
|
Pathways & Interactions
for R3HDML gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for R3HDML
|
Drugs & Compounds
for R3HDML gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for R3HDML
Search CenterWatch for drugs/clinical trials and news about R3HDML / CRSPL
|
Transcripts
for R3HDML gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for R3HDML gene: NM_178491.2 Unigene Cluster for R3HDML: R3H domain containing-like Hs.580807 [show with all ESTs]Unigene Representative Sequence: NM_1784911 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000217043(uc002xls.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for R3HDML (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for R3HDML
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: R3HDML (NM_178491) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for R3HDML | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat R3HDML |
Additional cDNA sequence: BC107048.2 1 DOTS entry: DT.92045296 2 AceView cDNA sequences: BG221330 NM_178491
GeneLoc Exon Structure
|
Expression
for R3HDML gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| R3HDML expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGTCAAAAGA
About this image
See R3HDML Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for R3HDML
SOURCE GeneReport for Unigene cluster: Hs.580807
SABiosciences Custom PCR Arrays for R3HDML
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for R3HDML
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat R3HDML | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat R3HDML | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat R3HDML | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for R3HDML |
Orthologs
for R3HDML gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for R3HDML gene from 3/12 species (see all 12) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
LOC1008580891 |
peptidase inhibitor R3HDML-like |
67.72(n)
64.43(a) |
|
100858089 XM_003642480.1 XP_003642528.1 |
lizard
(Anolis carolinensis) |
Reptilia |
R3HDML6 |
-- |
66(a) |
1 ↔ 1 |
4(144185006-144194677) |
zebrafish
(Danio rerio) |
Actinopterygii |
r3hdml6 |
R3H domain containing-like |
49(a) |
1 ↔ 1 |
23(26108394-26114709) |
ENSEMBL Gene Tree for R3HDML (if available)
TreeFam Gene Tree for R3HDML (if available) |
Paralogs
for R3HDML gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for R3HDML gene
- CLEC18B2 CRISPLD22 CLEC18C2 PI162 GLIPR12 CRISP22 PI152 CRISP12
- CRISPLD12 CRISP32 GLIPR1L12 CLEC18A2 GLIPR1L22
5 SIMAP similar genes for R3HDML using alignment to 1 protein entry: CRSPL_HUMAN:PI15 CRISPLD2 CRISPLD1 PI16 GLIPR1L1
R3HDML for paralogs About GeneDecksing
|
Genomic Variants
for R3HDML gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for R3HDML (42965626 - 42979875 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for R3HDML: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing R3HDML |
|
Disorders
/ Diseases
for R3HDML gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for R3HDML gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for R3HDML gene integrated from 9 sources:
(articles sorted by number of sources associating them with R3HDML) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Meta-analysis of genome-wide association studies ident ifies eight new loci for type 2 diabetes in east Asians. (PubMed id 22158537)1 Cho Y.S....Seielstad M. (2012)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)2 Deloukas P....Rogers J. (2001)
|
External Searches for R3HDML gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing R3HDML gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing R3HDML gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing R3HDML gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for R3HDML | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for R3HDML gene:
Search GeneIP for patents involving R3HDML
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for R3HDML gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for R3HDML | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for R3HDML | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for R3HDML | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for R3HDML | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for R3HDML | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for R3HDML | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for R3HDML | | OriGene Custom Protein Services for R3HDML | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat R3HDML | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing R3HDML | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat R3HDML | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat R3HDML | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat R3HDML | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat R3HDML |
| |
 |  |  |  | |
| | | | Search Tocris compounds for R3HDML |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | R3HDML Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for R3HDML |
|  |  |  |  | | | | Search ThermoFisher Antibodies for R3HDML |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat R3HDML |
| |  | |
|
|
|
