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Aliases for R3HDML Gene

Aliases for R3HDML Gene

  • R3H Domain Containing Like 2 3
  • R3H Domain Containing-Like 2 3 5
  • Cysteine-Rich Secretory Protein R3HDML 3 4
  • R3H Domain (Binds Single-Stranded Nucleic Acids) Containing-Like 2
  • DJ881L22.3 3

External Ids for R3HDML Gene

Previous GeneCards Identifiers for R3HDML Gene

  • GC20U990180
  • GC20M042654
  • GC20P043605
  • GC20P043651
  • GC20P042399
  • GC20P042965
  • GC20P039703

Summaries for R3HDML Gene

GeneCards Summary for R3HDML Gene

R3HDML (R3H Domain Containing Like) is a Protein Coding gene. GO annotations related to this gene include peptidase inhibitor activity. An important paralog of this gene is CLEC18B.

UniProtKB/Swiss-Prot for R3HDML Gene

  • Putative serine protease inhibitor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for R3HDML Gene

Genomics for R3HDML Gene

Regulatory Elements for R3HDML Gene

Enhancers for R3HDML Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around R3HDML on UCSC Golden Path with GeneCards custom track

Genomic Location for R3HDML Gene

Chromosome:
20
Start:
44,336,986 bp from pter
End:
44,351,235 bp from pter
Size:
14,250 bases
Orientation:
Plus strand

Genomic View for R3HDML Gene

Genes around R3HDML on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
R3HDML Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for R3HDML Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for R3HDML Gene

Proteins for R3HDML Gene

  • Protein details for R3HDML Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H3Y0-CRSPL_HUMAN
    Recommended name:
    Peptidase inhibitor R3HDML
    Protein Accession:
    Q9H3Y0

    Protein attributes for R3HDML Gene

    Size:
    253 amino acids
    Molecular mass:
    28605 Da
    Quaternary structure:
    No Data Available

neXtProt entry for R3HDML Gene

Proteomics data for R3HDML Gene at MOPED

Post-translational modifications for R3HDML Gene

No Post-translational modifications

Other Protein References for R3HDML Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for R3HDML Gene

Domains & Families for R3HDML Gene

Protein Domains for R3HDML Gene

Suggested Antigen Peptide Sequences for R3HDML Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H3Y0

UniProtKB/Swiss-Prot:

CRSPL_HUMAN :
  • Contains 1 SCP domain.
  • Belongs to the CRISP family.
Domain:
  • Contains 1 SCP domain.
Family:
  • Belongs to the CRISP family.
genes like me logo Genes that share domains with R3HDML: view

No data available for Gene Families for R3HDML Gene

Function for R3HDML Gene

Molecular function for R3HDML Gene

UniProtKB/Swiss-Prot Function:
Putative serine protease inhibitor.
genes like me logo Genes that share phenotypes with R3HDML: view

Animal Model Products

miRNA for R3HDML Gene

miRTarBase miRNAs that target R3HDML

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for R3HDML Gene

Localization for R3HDML Gene

Subcellular locations from UniProtKB/Swiss-Prot for R3HDML Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for R3HDML Gene COMPARTMENTS Subcellular localization image for R3HDML gene
Compartment Confidence
extracellular 4
nucleus 2
cytosol 1

No data available for Gene Ontology (GO) - Cellular Components for R3HDML Gene

Pathways & Interactions for R3HDML Gene

SuperPathways for R3HDML Gene

No Data Available

Interacting Proteins for R3HDML Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000217043%0d%0a9606.ENSP00000280527%0d%0a
Selected Interacting proteins: ENSP00000217043 for R3HDML Gene via STRING

Symbol External ID(s) Details
CRIM1

Gene Ontology (GO) - Biological Process for R3HDML Gene

None

No data available for Pathways by source and SIGNOR curated interactions for R3HDML Gene

Drugs & Compounds for R3HDML Gene

No Compound Related Data Available

Transcripts for R3HDML Gene

mRNA/cDNA for R3HDML Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for R3HDML Gene

R3H domain containing-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for R3HDML Gene

No ASD Table

Relevant External Links for R3HDML Gene

GeneLoc Exon Structure for
R3HDML
ECgene alternative splicing isoforms for
R3HDML

Expression for R3HDML Gene

mRNA expression in normal human tissues for R3HDML Gene

mRNA differential expression in normal tissues according to GTEx for R3HDML Gene

This gene is overexpressed in Colon - Transverse (x19.2), Small Intestine - Terminal Ileum (x6.3), and Testis (x6.0).

Protein differential expression in normal tissues from HIPED for R3HDML Gene

This gene is overexpressed in Liver (39.0) and Kidney (29.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for R3HDML Gene



SOURCE GeneReport for Unigene cluster for R3HDML Gene Hs.580807

genes like me logo Genes that share expression patterns with R3HDML: view

Protein tissue co-expression partners for R3HDML Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for R3HDML Gene

Orthologs for R3HDML Gene

This gene was present in the common ancestor of animals.

Orthologs for R3HDML Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia R3HDML 35
  • 85.19 (n)
  • 81.75 (a)
R3HDML 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia R3HDML 35
  • 86.64 (n)
  • 85.32 (a)
R3HDML 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia R3hdml 35
  • 81.55 (n)
  • 77.87 (a)
R3hdml 16
R3hdml 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia R3HDML 35
  • 99.21 (n)
  • 98.81 (a)
R3HDML 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia R3hdml 35
  • 79.84 (n)
  • 78.66 (a)
oppossum
(Monodelphis domestica)
Mammalia R3HDML 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia R3HDML 36
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100858089 35
  • 67.72 (n)
  • 64.43 (a)
R3HDML 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia R3HDML 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia r3hdml 35
  • 65.22 (n)
  • 60.08 (a)
zebrafish
(Danio rerio)
Actinopterygii r3hdml 36
  • 50 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG8483 36
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea scl-22 36
  • 12 (a)
ManyToMany
scl-23 36
  • 18 (a)
ManyToMany
vap-1 36
  • 11 (a)
ManyToMany
Species with no ortholog for R3HDML:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for R3HDML Gene

ENSEMBL:
Gene Tree for R3HDML (if available)
TreeFam:
Gene Tree for R3HDML (if available)

Paralogs for R3HDML Gene

(5) SIMAP similar genes for R3HDML Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with R3HDML: view

Variants for R3HDML Gene

Sequence variations from dbSNP and Humsavar for R3HDML Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs11699901 - 44,337,201(+) GCTCT(G/T)CTGGG reference, missense
rs36117710 - 44,337,359(-) ATAAT(C/T)CAGTA reference, missense
rs1884612 -- 44,337,385(+) GCCAG(C/T)GTGTA reference, synonymous-codon
rs3746570 -- 44,337,223(+) GTGAA(C/T)GCCTT reference, synonymous-codon
rs3761184 -- 44,341,158(+) GTGGC(A/G/T)ATTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for R3HDML Gene

Variant ID Type Subtype PubMed ID
nsv3389 CNV Insertion 18451855

Variation tolerance for R3HDML Gene

Residual Variation Intolerance Score: 86.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.84; 67.20% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for R3HDML Gene

Disorders for R3HDML Gene

Relevant External Links for R3HDML

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
R3HDML

No disorders were found for R3HDML Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for R3HDML Gene

Publications for R3HDML Gene

  1. Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. (PMID: 22158537) Cho Y.S. … Seielstad M. (Nat. Genet. 2012) 3 67
  2. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  3. A whole genome screen for HIV restriction factors. (PMID: 22082156) Liu L. … McKnight A. (Retrovirology 2011) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for R3HDML Gene

Sources for R3HDML Gene

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