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Aliases for R3HDM4 Gene

Aliases for R3HDM4 Gene

  • R3H Domain Containing 4 2 3 5
  • C19orf22 3 4
  • R3H Domain-Containing Protein C19orf22 3
  • Chromosome 19 Open Reading Frame 22 2

External Ids for R3HDM4 Gene

Previous HGNC Symbols for R3HDM4 Gene

  • C19orf22

Summaries for R3HDM4 Gene

GeneCards Summary for R3HDM4 Gene

R3HDM4 (R3H Domain Containing 4) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for R3HDM4 Gene

Genomics for R3HDM4 Gene

Regulatory Elements for R3HDM4 Gene

Promoters for R3HDM4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around R3HDM4 on UCSC Golden Path with GeneCards custom track

Genomic Location for R3HDM4 Gene

Chromosome:
19
Start:
896,503 bp from pter
End:
913,245 bp from pter
Size:
16,743 bases
Orientation:
Minus strand

Genomic View for R3HDM4 Gene

Genes around R3HDM4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
R3HDM4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for R3HDM4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for R3HDM4 Gene

Proteins for R3HDM4 Gene

  • Protein details for R3HDM4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96D70-R3HD4_HUMAN
    Recommended name:
    R3H domain-containing protein 4
    Protein Accession:
    Q96D70

    Protein attributes for R3HDM4 Gene

    Size:
    268 amino acids
    Molecular mass:
    30350 Da
    Quaternary structure:
    No Data Available

neXtProt entry for R3HDM4 Gene

Proteomics data for R3HDM4 Gene at MOPED

Post-translational modifications for R3HDM4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for R3HDM4 Gene

No data available for DME Specific Peptides for R3HDM4 Gene

Domains & Families for R3HDM4 Gene

Protein Domains for R3HDM4 Gene

Suggested Antigen Peptide Sequences for R3HDM4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96D70

UniProtKB/Swiss-Prot:

R3HD4_HUMAN :
  • Contains 1 R3H domain.
Domain:
  • Contains 1 R3H domain.
genes like me logo Genes that share domains with R3HDM4: view

No data available for Gene Families for R3HDM4 Gene

Function for R3HDM4 Gene

Phenotypes for R3HDM4 Gene

genes like me logo Genes that share phenotypes with R3HDM4: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for R3HDM4 Gene

Localization for R3HDM4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for R3HDM4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for R3HDM4 Gene COMPARTMENTS Subcellular localization image for R3HDM4 gene
Compartment Confidence
nucleus 5
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for R3HDM4 Gene

Pathways & Interactions for R3HDM4 Gene

SuperPathways for R3HDM4 Gene

No Data Available

Interacting Proteins for R3HDM4 Gene

Gene Ontology (GO) - Biological Process for R3HDM4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for R3HDM4 Gene

Drugs & Compounds for R3HDM4 Gene

No Compound Related Data Available

Transcripts for R3HDM4 Gene

Unigene Clusters for R3HDM4 Gene

R3H domain containing 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for R3HDM4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b
SP1: - - -
SP2: - - - -
SP3: - - - -
SP4: -
SP5:
SP6: -
SP7:

Relevant External Links for R3HDM4 Gene

GeneLoc Exon Structure for
R3HDM4
ECgene alternative splicing isoforms for
R3HDM4

Expression for R3HDM4 Gene

mRNA expression in normal human tissues for R3HDM4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for R3HDM4 Gene

This gene is overexpressed in Whole Blood (x23.6).

Protein differential expression in normal tissues from HIPED for R3HDM4 Gene

This gene is overexpressed in Lung (63.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for R3HDM4 Gene



SOURCE GeneReport for Unigene cluster for R3HDM4 Gene Hs.557655

genes like me logo Genes that share expression patterns with R3HDM4: view

Protein tissue co-expression partners for R3HDM4 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for R3HDM4 Gene

Orthologs for R3HDM4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for R3HDM4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia R3HDM4 35
  • 89.81 (n)
  • 94.44 (a)
R3HDM4 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia R3HDM4 35
  • 89.05 (n)
  • 92.16 (a)
R3HDM4 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia R3hdm4 35
  • 81.17 (n)
  • 86.64 (a)
R3hdm4 16
R3hdm4 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia R3HDM4 35
  • 99.63 (n)
  • 99.25 (a)
R3HDM4 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia R3hdm4 35
  • 82 (n)
  • 85.93 (a)
oppossum
(Monodelphis domestica)
Mammalia R3HDM4 36
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves R3HDM4 35
  • 71.58 (n)
  • 67.73 (a)
R3HDM4 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia r3hdm4 35
  • 62.4 (n)
  • 61.05 (a)
zebrafish
(Danio rerio)
Actinopterygii r3hdm4 35
  • 58.4 (n)
  • 55.46 (a)
r3hdm4 36
  • 49 (a)
OneToOne
Species with no ortholog for R3HDM4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for R3HDM4 Gene

ENSEMBL:
Gene Tree for R3HDM4 (if available)
TreeFam:
Gene Tree for R3HDM4 (if available)

Paralogs for R3HDM4 Gene

No data available for Paralogs for R3HDM4 Gene

Variants for R3HDM4 Gene

Sequence variations from dbSNP and Humsavar for R3HDM4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs7969 -- 896,740(+) GACCC(C/G)CAGCA utr-variant-3-prime
rs168405 -- 910,742(+) ACCTC(G/T)GTAGA intron-variant
rs1471815 -- 902,247(+) CCCTA(C/T)GGTGT intron-variant
rs901226 -- 903,168(+) ACATC(C/T)CCCAC intron-variant
rs350154 -- 912,435(+) GTTGG(C/G)GGGTG intron-variant

Variation tolerance for R3HDM4 Gene

Residual Variation Intolerance Score: 43.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.90; 74.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for R3HDM4 Gene

HapMap Linkage Disequilibrium report
R3HDM4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for R3HDM4 Gene

Disorders for R3HDM4 Gene

Relevant External Links for R3HDM4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
R3HDM4

No disorders were found for R3HDM4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for R3HDM4 Gene

Publications for R3HDM4 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PMID: 23314748) Nathan J.A. … Goldberg A.L. (EMBO J. 2013) 3

Products for R3HDM4 Gene

Sources for R3HDM4 Gene

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