Free for academic non-profit institutions. Other users need a Commercial license

Aliases for R3HDM4 Gene

Aliases for R3HDM4 Gene

  • R3H Domain Containing 4 2 3 5
  • C19orf22 3 4
  • R3H Domain-Containing Protein C19orf22 3
  • Chromosome 19 Open Reading Frame 22 2
  • R3H Domain-Containing Protein 4 3

External Ids for R3HDM4 Gene

Previous HGNC Symbols for R3HDM4 Gene

  • C19orf22

Summaries for R3HDM4 Gene

GeneCards Summary for R3HDM4 Gene

R3HDM4 (R3H Domain Containing 4) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for R3HDM4 Gene

Genomics for R3HDM4 Gene

Regulatory Elements for R3HDM4 Gene

Enhancers for R3HDM4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G000906 2 FANTOM5 Ensembl ENCODE dbSUPER 17.5 +4.7 4687 4.7 HDGF FOXA2 PKNOX1 CREB3L1 MLX ARNT AGO1 ARID4B SIN3A DMAP1 CFD MIDN ARHGAP45 R3HDM4 ABCA7 ELANE PRTN3 GZMM SBNO2 CIRBP
GH19G001236 1.9 FANTOM5 ENCODE dbSUPER 10.8 -343.6 -343614 41.1 CREB3L1 MLX AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF416 ZNF143 SF3A2 TMEM259 C19orf24 LOC100288123 CIRBP MIER2 MIDN ENSG00000267317 MUM1 RPS15
GH19G001025 1.8 FANTOM5 ENCODE dbSUPER 7.2 -115.1 -115136 5.8 PKNOX1 CREB3L1 ARNT AGO1 WRNIP1 ARID4B SIN3A DMAP1 ZNF143 SP3 ABCA7 CNN2 C19orf24 ARHGAP45 SCAMP4 GRIN3B SBNO2 GZMM R3HDM4 RNU6-2
GH19G001065 1.6 FANTOM5 ENCODE dbSUPER 7.3 -153.9 -153913 6.0 HDGF MLX AGO1 WRNIP1 ZFP64 SIN3A ARID4B DMAP1 ZNF2 ZNF143 ARHGAP45 ABCA7 LOC100288123 TMEM259 MIER2 POLR2E SBNO2 ENSG00000267317 POLRMT MIDN
GH19G000931 1.9 FANTOM5 Ensembl ENCODE dbSUPER 4.9 -20.5 -20529 4.1 HDGF FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 WDR18 CNN2 R3HDM4 MIDN CIRBP ENSG00000267159 GC19M000929
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around R3HDM4 on UCSC Golden Path with GeneCards custom track

Promoters for R3HDM4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000105573 545 1801 HDGF AGO1 SIN3A KDM4B SP3 ZNF592 CREB3 MXD3 NBN KDM1A

Genomic Location for R3HDM4 Gene

Chromosome:
19
Start:
896,503 bp from pter
End:
913,245 bp from pter
Size:
16,743 bases
Orientation:
Minus strand

Genomic View for R3HDM4 Gene

Genes around R3HDM4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
R3HDM4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for R3HDM4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for R3HDM4 Gene

Proteins for R3HDM4 Gene

  • Protein details for R3HDM4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96D70-R3HD4_HUMAN
    Recommended name:
    R3H domain-containing protein 4
    Protein Accession:
    Q96D70

    Protein attributes for R3HDM4 Gene

    Size:
    268 amino acids
    Molecular mass:
    30350 Da
    Quaternary structure:
    No Data Available

neXtProt entry for R3HDM4 Gene

Post-translational modifications for R3HDM4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for R3HDM4 Gene

No data available for DME Specific Peptides for R3HDM4 Gene

Domains & Families for R3HDM4 Gene

Protein Domains for R3HDM4 Gene

Suggested Antigen Peptide Sequences for R3HDM4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with R3HDM4: view

No data available for Gene Families and UniProtKB/Swiss-Prot for R3HDM4 Gene

Function for R3HDM4 Gene

Gene Ontology (GO) - Molecular Function for R3HDM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with R3HDM4: view

Phenotypes for R3HDM4 Gene

genes like me logo Genes that share phenotypes with R3HDM4: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for R3HDM4 Gene

Localization for R3HDM4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for R3HDM4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for R3HDM4 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for R3HDM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with R3HDM4: view

Pathways & Interactions for R3HDM4 Gene

SuperPathways for R3HDM4 Gene

No Data Available

Interacting Proteins for R3HDM4 Gene

Selected Interacting proteins: Q96D70-R3HD4_HUMAN for R3HDM4 Gene via IID

Symbol External ID(s) Details
ADIPOR1
UBC

Gene Ontology (GO) - Biological Process for R3HDM4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for R3HDM4 Gene

Drugs & Compounds for R3HDM4 Gene

No Compound Related Data Available

Transcripts for R3HDM4 Gene

Unigene Clusters for R3HDM4 Gene

R3H domain containing 4:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for R3HDM4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b
SP1: - - -
SP2: - - - -
SP3: - - - -
SP4: -
SP5:
SP6: -
SP7:

Relevant External Links for R3HDM4 Gene

GeneLoc Exon Structure for
R3HDM4
ECgene alternative splicing isoforms for
R3HDM4

Expression for R3HDM4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for R3HDM4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for R3HDM4 Gene

This gene is overexpressed in Whole Blood (x23.6).

Protein differential expression in normal tissues from HIPED for R3HDM4 Gene

This gene is overexpressed in Lung (63.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for R3HDM4 Gene



Protein tissue co-expression partners for R3HDM4 Gene

NURSA nuclear receptor signaling pathways regulating expression of R3HDM4 Gene:

R3HDM4

SOURCE GeneReport for Unigene cluster for R3HDM4 Gene:

Hs.557655

Evidence on tissue expression from TISSUES for R3HDM4 Gene

  • Skin(4.7)
  • Eye(4.4)
  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with R3HDM4: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for R3HDM4 Gene

Orthologs for R3HDM4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for R3HDM4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia R3HDM4 34 35
  • 99.63 (n)
cow
(Bos Taurus)
Mammalia R3HDM4 34 35
  • 89.81 (n)
dog
(Canis familiaris)
Mammalia R3HDM4 34 35
  • 89.05 (n)
rat
(Rattus norvegicus)
Mammalia R3hdm4 34
  • 82 (n)
mouse
(Mus musculus)
Mammalia R3hdm4 34 16 35
  • 81.17 (n)
oppossum
(Monodelphis domestica)
Mammalia R3HDM4 35
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves R3HDM4 34 35
  • 71.58 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia r3hdm4 34
  • 62.4 (n)
zebrafish
(Danio rerio)
Actinopterygii r3hdm4 34 35
  • 58.4 (n)
Species where no ortholog for R3HDM4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for R3HDM4 Gene

ENSEMBL:
Gene Tree for R3HDM4 (if available)
TreeFam:
Gene Tree for R3HDM4 (if available)

Paralogs for R3HDM4 Gene

No data available for Paralogs for R3HDM4 Gene

Variants for R3HDM4 Gene

Sequence variations from dbSNP and Humsavar for R3HDM4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000006737 -- 906,368(+) GTGCC(C/T)GCCAC intron-variant
rs1000410056 -- 902,636(+) TGTCC(A/C)AAAAA intron-variant
rs1000417558 -- 898,466(+) GTGCT(C/G)GCCGG intron-variant
rs1000694695 -- 901,642(+) TATCA(C/T)CTCAA intron-variant
rs1000752701 -- 897,629(+) GCTTC(C/T)TCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for R3HDM4 Gene

Variant ID Type Subtype PubMed ID
dgv134n111 CNV deletion 26073780
esv2665746 CNV deletion 23128226
nsv1112732 CNV deletion 24896259
nsv1160555 CNV deletion 26073780
nsv470101 CNV loss 18288195
nsv953938 CNV deletion 24416366
nsv9662 CNV gain 18304495

Variation tolerance for R3HDM4 Gene

Residual Variation Intolerance Score: 43.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.90; 74.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for R3HDM4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
R3HDM4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for R3HDM4 Gene

Disorders for R3HDM4 Gene

Relevant External Links for R3HDM4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
R3HDM4

No disorders were found for R3HDM4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for R3HDM4 Gene

Publications for R3HDM4 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PMID: 23314748) Nathan J.A. … Goldberg A.L. (EMBO J. 2013) 3 64
  4. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P. … Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012) 4 64

Products for R3HDM4 Gene

Sources for R3HDM4 Gene

Content
Loading form....