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Aliases for R3HDM4 Gene

Aliases for R3HDM4 Gene

  • R3H Domain Containing 4 2 3
  • C19orf22 3 4
  • R3H Domain-Containing Protein C19orf22 3
  • Chromosome 19 Open Reading Frame 22 2
  • R3H Domain-Containing Protein 4 3

External Ids for R3HDM4 Gene

Previous HGNC Symbols for R3HDM4 Gene

  • C19orf22

Summaries for R3HDM4 Gene

GeneCards Summary for R3HDM4 Gene

R3HDM4 (R3H Domain Containing 4) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for R3HDM4 Gene

Genomics for R3HDM4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for R3HDM4 Gene

896,503 bp from pter
913,245 bp from pter
16,743 bases
Minus strand

Genomic View for R3HDM4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for R3HDM4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for R3HDM4 Gene

No data available for Regulatory Elements for R3HDM4 Gene

Proteins for R3HDM4 Gene

  • Protein details for R3HDM4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    R3H domain-containing protein 4
    Protein Accession:
    Secondary Accessions:

    Protein attributes for R3HDM4 Gene

    268 amino acids
    Molecular mass:
    30350 Da
    Quaternary structure:
    No Data Available

neXtProt entry for R3HDM4 Gene

Proteomics data for R3HDM4 Gene at MOPED

Post-translational modifications for R3HDM4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for R3HDM4 Gene

No data available for DME Specific Peptides for R3HDM4 Gene

Domains for R3HDM4 Gene

Protein Domains for R3HDM4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q96D70
  • Contains 1 R3H domain.
genes like me logo Genes that share domains with R3HDM4: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for R3HDM4 Gene

Function for R3HDM4 Gene

Gene Ontology (GO) - Molecular Function for R3HDM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with R3HDM4: view

Animal Model Products

CRISPR Products

miRNA for R3HDM4 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for R3HDM4

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for R3HDM4 Gene

Localization for R3HDM4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for R3HDM4 Gene

Gene Ontology (GO) - Cellular Components for R3HDM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with R3HDM4: view

No data available for Subcellular locations from COMPARTMENTS for R3HDM4 Gene

Pathways for R3HDM4 Gene

SuperPathways for R3HDM4 Gene

No Data Available

Interacting Proteins for R3HDM4 Gene

Gene Ontology (GO) - Biological Process for R3HDM4 Gene


No data available for Pathways by source for R3HDM4 Gene

Transcripts for R3HDM4 Gene

mRNA/cDNA for R3HDM4 Gene

Unigene Clusters for R3HDM4 Gene

R3H domain containing 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for R3HDM4

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for R3HDM4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b
SP1: - - -
SP2: - - - -
SP3: - - - -
SP4: -
SP6: -

Relevant External Links for R3HDM4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for R3HDM4 Gene

mRNA expression in normal human tissues for R3HDM4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for R3HDM4 Gene

This gene is overexpressed in Whole Blood (23.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for R3HDM4 Gene

SOURCE GeneReport for Unigene cluster for R3HDM4 Gene Hs.557655

genes like me logo Genes that share expressions with R3HDM4: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for R3HDM4 Gene

Orthologs for R3HDM4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for R3HDM4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia R3HDM4 35
  • 99.63 (n)
  • 99.25 (a)
R3HDM4 36
  • 99 (a)
(Bos Taurus)
Mammalia R3HDM4 35
  • 89.81 (n)
  • 94.44 (a)
R3HDM4 36
  • 92 (a)
(Canis familiaris)
Mammalia R3HDM4 35
  • 89.05 (n)
  • 92.16 (a)
R3HDM4 36
  • 91 (a)
(Mus musculus)
Mammalia R3hdm4 35
  • 81.17 (n)
  • 86.64 (a)
R3hdm4 16
R3hdm4 36
  • 86 (a)
(Monodelphis domestica)
Mammalia R3HDM4 36
  • 67 (a)
(Rattus norvegicus)
Mammalia R3hdm4 35
  • 82 (n)
  • 85.93 (a)
(Gallus gallus)
Aves R3HDM4 35
  • 71.58 (n)
  • 67.73 (a)
R3HDM4 36
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia r3hdm4 35
  • 62.4 (n)
  • 61.05 (a)
(Danio rerio)
Actinopterygii r3hdm4 35
  • 58.4 (n)
  • 55.46 (a)
r3hdm4 36
  • 49 (a)
Species with no ortholog for R3HDM4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for R3HDM4 Gene

Gene Tree for R3HDM4 (if available)
Gene Tree for R3HDM4 (if available)

Paralogs for R3HDM4 Gene

No data available for Paralogs for R3HDM4 Gene

Variants for R3HDM4 Gene

Sequence variations from dbSNP and Humsavar for R3HDM4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs7969 -- 896,740(+) GACCC(C/G)CAGCA utr-variant-3-prime
rs168405 -- 910,742(+) ACCTC(G/T)GTAGA intron-variant
rs350154 -- 912,435(+) GTTGG(C/G)GGGTG intron-variant
rs350155 -- 912,538(+) gtggg(C/G)ggacg intron-variant
rs350156 -- 912,852(+) CAGGA(C/G)GGTGT intron-variant

Relevant External Links for R3HDM4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for R3HDM4 Gene

Disorders for R3HDM4 Gene

No disorders were found for R3HDM4 Gene.

No data available for UniProtKB/Swiss-Prot for R3HDM4 Gene

Publications for R3HDM4 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PMID: 23314748) Nathan J.A. … Goldberg A.L. (EMBO J. 2013) 3
  4. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P. … Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012) 4

Products for R3HDM4 Gene

Sources for R3HDM4 Gene

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