R3HDM4 Gene
protein-coding GIFtS: 38
GCID: GC19M000896
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R3H domain containing 4(Previous name: chromosome 19 open reading frame 22 )
(Previous symbol: C19orf22)
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Aliases
for R3HDM4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| R3H Domain Containing 41 2 | | C19orf221 2 3 | | MGC163531 | | Chromosome 19 Open Reading Frame 221 | | R3H Domain-Containing Protein 42 | | R3H Domain-Containing Protein C19orf222 |
Export aliases for R3HDM4 gene to outside databases |
Summaries
for R3HDM4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for R3HDM4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011255.14
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for R3HDM4
Other transcription factors
Search SABiosciences Chromatin IP Primers for R3HDM4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat R3HDM4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3R3HDM4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M000896: view genomic region
(about GC identifiers)
Start:
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896,503 bp from pter |
End:
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913,240 bp from pter |
Size:
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16,738 bases |
Orientation:
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minus strand |
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Proteins
for R3HDM4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: R3HD4_HUMAN, Q96D70 (See
protein sequence)Recommended Name: R3H domain-containing protein 4 Size: 268 amino acids; 30350 Da
Subcellular location: Nucleus (Potential)Explore the universe of human proteins at neXtProt for R3HDM4: NX_Q96D70
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96D70
R3HDM4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_620129.2
ENSEMBL proteins: ENSP00000355385 ENSP00000466823 ENSP00000464744 ENSP00000468026 ENSP00000466124 ENSP00000468088
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
R3HDM4 for ontologies About GeneDecksing
R3HDM4 Antibody Products:
Assay Products for R3HDM4: |
Protein
Domains /
Families
for R3HDM4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
R3HDM4 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96D70ProtoNet protein and cluster: Q96D70 1 Blocks protein family: IPB001374 Single-stranded nucleic acid binding R3H
UniProtKB/Swiss-Prot: R3HD4_HUMAN, Q96D70Similarity: Contains 1 R3H domain |
Function
for R3HDM4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for R3HDM4 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for R3HDM4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for R3HDM4 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for R3HDM4 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat R3HDM4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for R3HDM4 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003676 | nucleic acid binding |
IEA | -- |
R3HDM4 for ontologies About GeneDecksing
|
Pathways & Interactions
for R3HDM4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for R3HDM4
|
Drugs & Compounds
for R3HDM4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for R3HDM4
Search CenterWatch for drugs/clinical trials and news about R3HDM4 / R3HD4
|
Transcripts
for R3HDM4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for R3HDM4 gene: NM_138774.3 Unigene Cluster for R3HDM4: R3H domain containing 4 Hs.557655 [show with all ESTs]Unigene Representative Sequence: NM_1387748 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000361574(uc002lqg.2) ENST00000589428 ENST00000587975 ENST00000586080
ENST00000590454 ENST00000591829 ENST00000590259 ENST00000589445
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for R3HDM4 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for R3HDM4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for R3HDM4 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for R3HDM4 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat R3HDM4 |
Additional cDNA sequence: AK000263.1 AK024622.1 10 DOTS entries: DT.97845591 DT.100834608 DT.456358 DT.100782498 DT.95088837 DT.92440013 DT.75103121 DT.86851945 DT.95337198 DT.92440012 24/264 AceView cDNA sequences (see all 264): CR597374 AA431476 BM809880 BQ015838 BE336717 BM553385 CR617180 BI908462 BU185009 CA450068 CR608111 BE615026 BE302484 BI766685 CR606082 BU607795 BC012775 AI934784 BM462242 CR599301 CR619216 NM_138774 CR616128 CR615271
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for R3HDM4 (see all 7) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b |
|---|
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| SP1: | | | | | | | - | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | | | | | - | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for R3HDM4
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Expression
for R3HDM4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| R3HDM4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGGTCCTCC
About this image
See R3HDM4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for R3HDM4
SOURCE GeneReport for Unigene cluster: Hs.557655
SABiosciences Custom PCR Arrays for R3HDM4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for R3HDM4
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat R3HDM4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat R3HDM4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat R3HDM4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for R3HDM4 |
Orthologs
for R3HDM4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for R3HDM4 gene from 3/12 species (see all 12) About this table
ENSEMBL Gene Tree for R3HDM4 (if available)
TreeFam Gene Tree for R3HDM4 (if available) |
Paralogs
for R3HDM4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for R3HDM4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for R3HDM4 (896503 - 913240 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for R3HDM4: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing R3HDM4 |
|
Disorders
/ Diseases
for R3HDM4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for R3HDM4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for R3HDM4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with R3HDM4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
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External Searches for R3HDM4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing R3HDM4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing R3HDM4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing R3HDM4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for R3HDM4 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for R3HDM4 gene:
Search GeneIP for patents involving R3HDM4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for R3HDM4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for R3HDM4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for R3HDM4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for R3HDM4 | | | OriGene Protein Over-expression Lysate for R3HDM4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for R3HDM4 | | OriGene 3'-UTR Clone for R3HDM4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for R3HDM4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for R3HDM4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | Search Tocris compounds for R3HDM4 |
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 | | | R3HDM4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for R3HDM4 |
|  |  |  | | | | ThermoFisher Antibodies for R3HDM4 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat R3HDM4 |
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