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Aliases for R3HDM2 Gene

Aliases for R3HDM2 Gene

  • R3H Domain Containing 2 2 3 5
  • R3H Domain-Containing Protein 2 3
  • KIAA1002 4
  • PR01365 3
  • CAG6 3

External Ids for R3HDM2 Gene

Previous GeneCards Identifiers for R3HDM2 Gene

  • GC12M055934
  • GC12M057647
  • GC12M054686

Summaries for R3HDM2 Gene

GeneCards Summary for R3HDM2 Gene

R3HDM2 (R3H Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and poly(A) RNA binding. An important paralog of this gene is R3HDM1.

Additional gene information for R3HDM2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for R3HDM2 Gene

Genomics for R3HDM2 Gene

Regulatory Elements for R3HDM2 Gene

Enhancers for R3HDM2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H057454 1.6 Ensembl ENCODE dbSUPER 10.7 -24.8 -24766 3.5 HDGF PKNOX1 MLX ARNT ARID4B DMAP1 ZNF2 YY1 ZNF766 CBX5 NEMP1 BAZ2A ENSG00000224713 MBD6 SLC26A10 RPL13AP23 LINC02403 RPL21P103 RN7SL809P RNU6-343P
GH12H057109 1.5 ENCODE dbSUPER 10.4 +319.8 319752 3.8 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 SP3 MCM3 MEF2D SSRP1 NEMP1 BAZ2A EEF1AKMT3 ENSG00000257740 SMARCC2 CDK4 CTDSP2 PAN2 ANKRD52 DTX3
GH12H056718 1.4 ENCODE dbSUPER 11 +708.4 708447 8.9 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZNF610 GLIS1 NBN BAZ2A NEMP1 ZC3H10 DNAJC14 ENSG00000258317 SMARCC2 ANKRD52 STAT2 PRIM1 ATP5B
GH12H056628 1.4 ENCODE dbSUPER 11 +801.3 801324 3 HDGF FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 CBX5 ZNF207 NEMP1 RBMS2 RNU6-343P BAZ2A PTGES3 ZC3H10 R3HDM2 SMARCC2 ENSG00000258317 GLS2
GH12H057516 1.4 ENCODE dbSUPER 10.5 -90.1 -90084 8.8 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 NFYC ZFP41 MEF2D NEMP1 BAZ2A RN7SL809P DTX3 ZBTB39 MBD6 ENSG00000224713 CTDSP2 EEF1AKMT3 DCTN2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around R3HDM2 on UCSC Golden Path with GeneCards custom track

Promoters for R3HDM2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for R3HDM2 Gene

Genomic Locations for R3HDM2 Gene
177,244 bases
Minus strand

Genomic View for R3HDM2 Gene

Genes around R3HDM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
R3HDM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for R3HDM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for R3HDM2 Gene

Proteins for R3HDM2 Gene

  • Protein details for R3HDM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    R3H domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • B7ZL65
    • Q2M1T9
    • Q3ZCT5

    Protein attributes for R3HDM2 Gene

    976 amino acids
    Molecular mass:
    106999 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI04996.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI12227.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA76846.2; Type=Frameshift; Positions=4; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for R3HDM2 Gene

    Alternative splice isoforms for R3HDM2 Gene


neXtProt entry for R3HDM2 Gene

Post-translational modifications for R3HDM2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for R3HDM2 Gene

Domains & Families for R3HDM2 Gene

Gene Families for R3HDM2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for R3HDM2 Gene

Suggested Antigen Peptide Sequences for R3HDM2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with R3HDM2: view

No data available for UniProtKB/Swiss-Prot for R3HDM2 Gene

Function for R3HDM2 Gene

Phenotypes From GWAS Catalog for R3HDM2 Gene

Gene Ontology (GO) - Molecular Function for R3HDM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
genes like me logo Genes that share ontologies with R3HDM2: view
genes like me logo Genes that share phenotypes with R3HDM2: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for R3HDM2 Gene

Localization for R3HDM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for R3HDM2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for R3HDM2 gene
Compartment Confidence
nucleus 5
cytosol 3
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for R3HDM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with R3HDM2: view

Pathways & Interactions for R3HDM2 Gene

SuperPathways for R3HDM2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for R3HDM2 Gene


No data available for Pathways by source and SIGNOR curated interactions for R3HDM2 Gene

Drugs & Compounds for R3HDM2 Gene

No Compound Related Data Available

Transcripts for R3HDM2 Gene

Unigene Clusters for R3HDM2 Gene

R3H domain containing 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for R3HDM2 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^
SP1: -
SP2: - -
SP3: -
SP4: - - -
SP5: - - -
SP6: -

ExUns: 18 ^ 19

Relevant External Links for R3HDM2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for R3HDM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for R3HDM2 Gene

Protein differential expression in normal tissues from HIPED for R3HDM2 Gene

This gene is overexpressed in Plasma (40.9), Frontal cortex (14.8), and Fetal Brain (13.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for R3HDM2 Gene

Protein tissue co-expression partners for R3HDM2 Gene

NURSA nuclear receptor signaling pathways regulating expression of R3HDM2 Gene:


SOURCE GeneReport for Unigene cluster for R3HDM2 Gene:


Evidence on tissue expression from TISSUES for R3HDM2 Gene

  • Nervous system(4.5)
  • Liver(4.3)
genes like me logo Genes that share expression patterns with R3HDM2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for R3HDM2 Gene

Orthologs for R3HDM2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for R3HDM2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia R3HDM2 33
  • 95.96 (n)
(Bos Taurus)
Mammalia R3HDM2 33 34
  • 94.67 (n)
(Canis familiaris)
Mammalia R3HDM2 33 34
  • 94.5 (n)
(Mus musculus)
Mammalia R3hdm2 33 16 34
  • 91.8 (n)
(Rattus norvegicus)
Mammalia R3hdm2 33
  • 91.58 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 81 (a)
(Gallus gallus)
Aves R3HDM2 33
  • 75.81 (n)
-- 34
  • 70 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia r3hdm2 33
  • 69.97 (n)
(Danio rerio)
Actinopterygii r3hdm2 33
  • 68.57 (n)
arpp21 34
  • 32 (a)
fruit fly
(Drosophila melanogaster)
Insecta enc 34
  • 10 (a)
(Caenorhabditis elegans)
Secernentea ZK121.2 34
  • 23 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RBS1 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 18 (a)
Species where no ortholog for R3HDM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for R3HDM2 Gene

Gene Tree for R3HDM2 (if available)
Gene Tree for R3HDM2 (if available)

Paralogs for R3HDM2 Gene

Paralogs for R3HDM2 Gene

(3) SIMAP similar genes for R3HDM2 Gene using alignment to 9 proteins: Pseudogenes for R3HDM2 Gene

genes like me logo Genes that share paralogs with R3HDM2: view

Variants for R3HDM2 Gene

Sequence variations from dbSNP and Humsavar for R3HDM2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000024056 -- 57,342,460(+) CTGGC(A/T)CATAC intron-variant, upstream-variant-2KB
rs1000026389 -- 57,309,302(+) GCATG(A/C)AGGAA intron-variant
rs1000080453 -- 57,302,125(+) AAAAC(A/C)CAAAA intron-variant
rs1000084620 -- 57,419,230(+) CCTCC(A/G)CCTCC intron-variant
rs1000086461 -- 57,306,761(+) TGTAA(A/T)CCCAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for R3HDM2 Gene

Variant ID Type Subtype PubMed ID
esv1358710 CNV deletion 17803354
nsv1134233 CNV deletion 24896259
nsv1138139 CNV deletion 24896259
nsv482992 CNV gain+loss 15286789

Variation tolerance for R3HDM2 Gene

Residual Variation Intolerance Score: 22.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.44; 64.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for R3HDM2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for R3HDM2 Gene

Disorders for R3HDM2 Gene

Relevant External Links for R3HDM2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for R3HDM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for R3HDM2 Gene

Publications for R3HDM2 Gene

  1. Biological, clinical and population relevance of 95 loci for blood lipids. (PMID: 20686565) Teslovich TM … Kathiresan S (Nature 2010) 3 45 60
  2. Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors. (PMID: 20884846) Yang Q … Coresh J (Circulation. Cardiovascular genetics 2010) 3 45 60
  3. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 3 4 60
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60
  5. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) Schizophrenia Working Group of the Psychiatric Genomics Consortium (Nature 2014) 3 60

Products for R3HDM2 Gene

Sources for R3HDM2 Gene

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