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Aliases for R3HDM2 Gene

Aliases for R3HDM2 Gene

  • R3H Domain Containing 2 2 3
  • R3H Domain-Containing Protein 2 3
  • KIAA1002 4
  • PR01365 3

External Ids for R3HDM2 Gene

Previous GeneCards Identifiers for R3HDM2 Gene

  • GC12M055934
  • GC12M057647
  • GC12M054686

Summaries for R3HDM2 Gene

GeneCards Summary for R3HDM2 Gene

R3HDM2 (R3H Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is R3HDM1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for R3HDM2 Gene

Genomics for R3HDM2 Gene

Regulatory Elements for R3HDM2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for R3HDM2 Gene

Start:
57,253,762 bp from pter
End:
57,431,005 bp from pter
Size:
177,244 bases
Orientation:
Minus strand

Genomic View for R3HDM2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for R3HDM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for R3HDM2 Gene

Proteins for R3HDM2 Gene

  • Protein details for R3HDM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2K5-R3HD2_HUMAN
    Recommended name:
    R3H domain-containing protein 2
    Protein Accession:
    Q9Y2K5
    Secondary Accessions:
    • B7ZL65
    • Q2M1T9
    • Q3ZCT5

    Protein attributes for R3HDM2 Gene

    Size:
    976 amino acids
    Molecular mass:
    106999 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI04996.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI12227.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA76846.2; Type=Frameshift; Positions=4; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for R3HDM2 Gene

    Alternative splice isoforms for R3HDM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for R3HDM2 Gene

Proteomics data for R3HDM2 Gene at MOPED

Post-translational modifications for R3HDM2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for R3HDM2 Gene

Domains for R3HDM2 Gene

Protein Domains for R3HDM2 Gene

Suggested Antigen Peptide Sequences for R3HDM2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y2K5

UniProtKB/Swiss-Prot:

R3HD2_HUMAN :
  • Q9Y2K5
Domain:
  • Contains 1 R3H domain.
  • Contains 1 SUZ domain.
genes like me logo Genes that share domains with R3HDM2: view

No data available for Gene Families for R3HDM2 Gene

Function for R3HDM2 Gene

Gene Ontology (GO) - Molecular Function for R3HDM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0005515 protein binding IPI 25416956
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with R3HDM2: view

Phenotypes for R3HDM2 Gene

GenomeRNAi human phenotypes for R3HDM2:
genes like me logo Genes that share phenotypes with R3HDM2: view

Animal Model Products

miRNA for R3HDM2 Gene

miRTarBase miRNAs that target R3HDM2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for R3HDM2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for R3HDM2 Gene

Localization for R3HDM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for R3HDM2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for R3HDM2 Gene COMPARTMENTS Subcellular localization image for R3HDM2 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for R3HDM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with R3HDM2: view

Pathways for R3HDM2 Gene

SuperPathways for R3HDM2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for R3HDM2 Gene

None

No data available for Pathways by source for R3HDM2 Gene

Transcripts for R3HDM2 Gene

Unigene Clusters for R3HDM2 Gene

R3H domain containing 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for R3HDM2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for R3HDM2 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^
SP1: -
SP2: - -
SP3: -
SP4: - - -
SP5: - - -
SP6: -
SP7:
SP8:

ExUns: 18 ^ 19
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for R3HDM2 Gene

GeneLoc Exon Structure for
R3HDM2
ECgene alternative splicing isoforms for
R3HDM2

Expression for R3HDM2 Gene

mRNA expression in normal human tissues for R3HDM2 Gene

Protein differential expression in normal tissues for R3HDM2 Gene

This gene is overexpressed in Plasma (40.9), Frontal cortex (14.8), and Fetal Brain (13.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for R3HDM2 Gene

SOURCE GeneReport for Unigene cluster for R3HDM2 Gene Hs.443673

genes like me logo Genes that share expressions with R3HDM2: view

Expression partners for R3HDM2 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for R3HDM2 Gene

Orthologs for R3HDM2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for R3HDM2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia R3HDM2 35
  • 94.67 (n)
  • 97.6 (a)
R3HDM2 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia R3HDM2 35
  • 94.5 (n)
  • 96.31 (a)
R3HDM2 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia R3hdm2 35
  • 91.8 (n)
  • 95.7 (a)
R3hdm2 16
R3hdm2 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia R3HDM2 35
  • 95.96 (n)
  • 95.4 (a)
rat
(Rattus norvegicus)
Mammalia R3hdm2 35
  • 91.58 (n)
  • 94.47 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 81 (a)
OneToMany
chicken
(Gallus gallus)
Aves R3HDM2 35
  • 75.81 (n)
  • 80.05 (a)
-- 36
  • 70 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 78 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia r3hdm2 35
  • 69.97 (n)
  • 73.51 (a)
zebrafish
(Danio rerio)
Actinopterygii r3hdm2 35
  • 68.57 (n)
  • 69.8 (a)
arpp21 36
  • 32 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta enc 36
  • 10 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ZK121.2 36
  • 23 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RBS1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 18 (a)
OneToMany
Species with no ortholog for R3HDM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for R3HDM2 Gene

ENSEMBL:
Gene Tree for R3HDM2 (if available)
TreeFam:
Gene Tree for R3HDM2 (if available)

Paralogs for R3HDM2 Gene

Paralogs for R3HDM2 Gene

Selected SIMAP similar genes for R3HDM2 Gene using alignment to 9 proteins:

Pseudogenes.org Pseudogenes for R3HDM2 Gene

genes like me logo Genes that share paralogs with R3HDM2: view

Variants for R3HDM2 Gene

Sequence variations from dbSNP and Humsavar for R3HDM2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs481196 -- 57,432,350(-) TTCTC(C/T)AGAGG upstream-variant-2KB
rs487722 -- 57,430,382(+) CGAAG(G/T)AAAAC intron-variant
rs491750 -- 57,397,393(+) TCTAT(G/T)CTAAA intron-variant, upstream-variant-2KB
rs492749 -- 57,387,435(+) gcaag(A/G)gtccg intron-variant
rs501055 -- 57,400,941(+) TATCA(A/G)TCCCC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for R3HDM2 Gene

Variant ID Type Subtype PubMed ID
esv1358710 CNV Deletion 17803354

Relevant External Links for R3HDM2 Gene

HapMap Linkage Disequilibrium report
R3HDM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for R3HDM2 Gene

Disorders for R3HDM2 Gene

Relevant External Links for R3HDM2

Genetic Association Database (GAD)
R3HDM2
Human Genome Epidemiology (HuGE) Navigator
R3HDM2

No disorders were found for R3HDM2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for R3HDM2 Gene

Publications for R3HDM2 Gene

  1. Biological, clinical and population relevance of 95 loci for blood lipids. (PMID: 20686565) Teslovich T.M. … Kathiresan S. (Nature 2010) 3 48
  2. Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors. (PMID: 20884846) Yang Q. … Coresh J. (Circ Cardiovasc Genet 2010) 3 48
  3. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 3 4
  4. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PMID: 10737800) Dias Neto E. … Simpson A.J.G. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for R3HDM2 Gene

Sources for R3HDM2 Gene

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